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Parkinson's fmri

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https://www.readbyqxmd.com/read/28851996/uncovering-the-underlying-mechanisms-and-whole-brain-dynamics-of-deep-brain-stimulation-for-parkinson-s-disease
#1
Victor M Saenger, Joshua Kahan, Tom Foltynie, Karl Friston, Tipu Z Aziz, Alexander L Green, Tim J van Hartevelt, Joana Cabral, Angus B A Stevner, Henrique M Fernandes, Laura Mancini, John Thornton, Tarek Yousry, Patricia Limousin, Ludvic Zrinzo, Marwan Hariz, Paulo Marques, Nuno Sousa, Morten L Kringelbach, Gustavo Deco
Deep brain stimulation (DBS) for Parkinson's disease is a highly effective treatment in controlling otherwise debilitating symptoms. Yet the underlying brain mechanisms are currently not well understood. Whole-brain computational modeling was used to disclose the effects of DBS during resting-state functional Magnetic Resonance Imaging in ten patients with Parkinson's disease. Specifically, we explored the local and global impact that DBS has in creating asynchronous, stable or critical oscillatory conditions using a supercritical bifurcation model...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28828757/longitudinal-alterations-of-local-spontaneous-brain-activity-in-parkinson-s-disease
#2
Qiaoling Zeng, Xiaojun Guan, Jason C F Law Yan Lun, Zhujing Shen, Tao Guo, Min Xuan, Quanquan Gu, Xiaojun Xu, Min Chen, Minming Zhang
We used resting-state fMRI to evaluate longitudinal alterations in local spontaneous brain activity in Parkinson's disease (PD) over a 2-year period. Data were acquired from 23 PD patients at baseline and follow-up, and 27 age- and sex-matched normal controls. Regional homogeneity (ReHo) and voxel-based-morphometry (VBM) were used to identify differences in local spontaneous brain activity and grey matter volume. With disease progression, we observed a progressive decrease in ReHo in the sensorimotor cortex, default-mode network, and left cerebellum, but increased ReHo in the supplementary motor area, bilateral temporal gyrus, and hippocampus...
August 21, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/28812218/neural-correlates-of-emotional-valence-processing-in-parkinson-s-disease-dysfunction-in-the-subcortex
#3
Peter T Bell, Moran Gilat, James M Shine, Katie L McMahon, Simon J G Lewis, David A Copland
Parkinson's disease (PD) is frequently accompanied by cognitive and neuropsychiatric symptoms including impairments in affective processing. Despite this, mechanisms underlying vulnerability to deficits in affective processing remain unclear. In this study, we utilized functional Magnetic Resonance Imaging (fMRI) and an Affective Go-NoGo paradigm, to examine the neural correlates of emotional valence processing in PD. Results suggest that PD is associated with aberrant processing of emotional valence in subcortical limbic structures...
August 15, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28802921/imaging-the-nonmotor-symptoms-in-parkinson-s-disease
#4
Tayyabah Yousaf, Heather Wilson, Marios Politis
Parkinson's disease is acknowledged to be a multisystem syndrome, manifesting as a result of multineuropeptide dysfunction, including dopaminergic, cholinergic, serotonergic, and noradrenergic deficits. This multisystem disorder ultimately leads to the presentation of a range of nonmotor symptoms, now appreciated to be an integral part of the disease-specific spectrum of symptoms, often preceding the diagnosis of motor Parkinson's disease. In this chapter, we review the dopaminergic and nondopaminergic basis of these symptoms by exploring the neuroimaging evidence based on several techniques including positron emission tomography, single-photon emission computed tomography molecular imaging, magnetic resonance imaging, functional magnetic resonance imaging, and diffusion tensor imaging...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/28789983/impaired-brain-network-architecture-in-newly-diagnosed-parkinson-s-disease-based-on-graph-theoretical-analysis
#5
Jinping Fang, Huimin Chen, Zhentang Cao, Ying Jiang, Lingyan Ma, Huizi Ma, Tao Feng
BACKGROUND: Resting state functional magnetic resonance imaging (rs-fMRI) has been applied to investigate topographic structure in Parkinson's disease (PD). Alteration of topographic architecture has been inconsistent in PD AIM: To investigate the network profile of PD using graph theoretical analysis. METHOD: Twenty six newly diagnosed PD and 19 age- and gender- matched healthy controls (HC) were included in our analysis. Small-world profile and topographic profiles (nodal degree, global efficiency, local efficiency, cluster coefficient, shortest path length, betweenness centrality) were measured and compared between groups, with age and gender as covariates...
August 5, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28769862/correlation-between-dopamine-transporter-degradation-and-striatocortical-network-alteration-in-parkinson-s-disease
#6
Wei-Che Lin, Hsiu-Ling Chen, Tun-Wei Hsu, Chien-Chin Hsu, Yung-Cheng Huang, Nai-Wen Tsai, Cheng-Hsien Lu
The association between dopamine neuron loss and functional change in the striatocortical network was analyzed in 31 patients with Parkinson's disease (PD) [mean disease duration 4.03 ± 4.20 years; Hoehn and Yahr (HY) stage 2.2 ± 1.2] and 37 age-matched normal control subjects. We performed (99m)Tc-TRODAT-1 SPECT/CT imaging to detect neuron losses and resting-state functional magnetic resonance imaging to detect functional changes. Mean striatal dopamine transporter binding ratios were determined by region of interest analysis...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28765808/altered-praxis-network-underlying-limb-kinetic-apraxia-in-parkinson-s-disease-an-fmri-study
#7
Stefanie Kübel, Katharina Stegmayer, Tim Vanbellingen, Manuela Pastore-Wapp, Manuel Bertschi, Jean-Marc Burgunder, Eugenio Abela, Bruno Weder, Sebastian Walther, Stephan Bohlhalter
Parkinson's disease (PD) patients frequently suffer from dexterous deficits impeding activities of daily living. There is controversy whether impaired fine motor skill may stem from limb kinetic apraxia (LKA) rather than bradykinesia. Based on classical models of limb praxis LKA is thought to result when premotor transmission of time-space information of skilled movements to primary motor representations is interrupted. Therefore, using functional magnetic resonance imaging (fMRI) we tested the hypothesis that dexterous deficits in PD are associated with altered activity and connectivity in left parieto-premotor praxis network...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28763447/braph-a-graph-theory-software-for-the-analysis-of-brain-connectivity
#8
Mite Mijalkov, Ehsan Kakaei, Joana B Pereira, Eric Westman, Giovanni Volpe
The brain is a large-scale complex network whose workings rely on the interaction between its various regions. In the past few years, the organization of the human brain network has been studied extensively using concepts from graph theory, where the brain is represented as a set of nodes connected by edges. This representation of the brain as a connectome can be used to assess important measures that reflect its topological architecture. We have developed a freeware MatLab-based software (BRAPH-BRain Analysis using graPH theory) for connectivity analysis of brain networks derived from structural magnetic resonance imaging (MRI), functional MRI (fMRI), positron emission tomography (PET) and electroencephalogram (EEG) data...
2017: PloS One
https://www.readbyqxmd.com/read/28727571/altered-putamen-functional-connectivity-is-associated-with-anxiety-disorder-in-parkinson-s-disease
#9
Xixi Wang, Junyi Li, Yongsheng Yuan, Min Wang, Jian Ding, Jiejin Zhang, Lin Zhu, Yuting Shen, Hui Zhang, Kezhong Zhang
In this study, we used resting state-functional magnetic resonance imaging (rs-fMRI) to explore altered putamen functional connectivity (FC) in Parkinson's disease patients with anxiety disorder. We divided 65 Parkinson's disease patients into anxiety (PD-A; n=18) and non-anxiety (PD-NA; n=45) groups based on a Hamilton Anxiety Rating Scale cutoff score of 12. The PD-A patients exhibited altered putamen FC with cortical and subcortical regions. The PD-A patients showed enhanced putamen FC with the caudatum, which correlated with increased emotional processing during anxiety...
July 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28715349/altered-neural-responses-to-heat-pain-in-drug-naive-patients-with-parkinson-disease
#10
Katarina Forkmann, Wiebke Grashorn, Katharina Schmidt, Odette Fründt, Carsten Buhmann, Ulrike Bingel
Pain is a frequent but still neglected nonmotor symptom of Parkinson disease (PD). However, neural mechanisms underlying pain in PD are poorly understood. Here, we explored whether the high prevalence of pain in PD might be related to dysfunctional descending pain control. Using functional magnetic resonance imaging we explored neural responses during the anticipation and processing of heat pain in 21 PD patients (Hoehn and Yahr I-III) and 23 healthy controls (HC). Parkinson disease patients were naive to dopaminergic medication to avoid confounding drug effects...
August 2017: Pain
https://www.readbyqxmd.com/read/28712121/motor-symptom-laterality-affects-acquisition-in-parkinson-s-disease-a-cognitive-and-functional-magnetic-resonance-imaging-study
#11
Pei Huang, Yu-Yan Tan, Dong-Qiang Liu, Mohammad M Herzallah, Elizabeth Lapidow, Ying Wang, Yu-Feng Zang, Mark A Gluck, Sheng-Di Chen
BACKGROUND AND OBJECTIVES: Asymmetric onset of motor symptoms in PD can affect cognitive function. We examined whether motor-symptom laterality could affect feedback-based associative learning and explored its underlying neural mechanism by functional magnetic resonance imaging in PD patients. METHODS: We recruited 63 early-stage medication-naïve PD patients (29 left-onset medication-naïve patients, 34 right-onset medication-naïve patients) and 38 matched normal controls...
July 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28675834/effects-of-levodopa-on-corticostriatal-circuits-supporting-working-memory-in-parkinson-s-disease
#12
Alison C Simioni, Alain Dagher, Lesley K Fellows
Working memory dysfunction is common in Parkinson's disease, even in its early stages, but its neural basis is debated. Working memory performance likely reflects a balance between corticostriatal dysfunction and compensatory mechanisms. We tested this hypothesis by examining working memory performance with a letter n-back task in 19 patients with mild-moderate Parkinson's disease and 20 demographically matched healthy controls. Parkinson's disease patients were tested after an overnight washout of their usual dopamine replacement therapy, and again after a standard dose of levodopa...
August 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28668411/functional-and-structural-changes-in-gray-matter-of-parkinson-s-disease-patients-with-mild-cognitive-impairment
#13
Boyu Chen, Shanshan Wang, Wenge Sun, Xiuli Shang, Hu Liu, Guohao Liu, Jie Gao, Guoguang Fan
BACKGROUND AND PURPOSE: Cognitive impairment is a common non-motor complication of Parkinson's disease (PD). To investigate cognitive-related changes of gray matter (GM) structure and function in PD using voxel-based morphometry (VBM) and resting state functional connectivity (RSFC). MATERIALS AND METHODS: Resting state functional magnetic resonance imaging (rs-fMRI) and 3D-T1-weighted MRI scans were obtained from 21 PD patients with mild cognitive impairment (PD-MCI), 11 PD patients with normal cognitive function (PD-NC), and 21 healthy controls (HC)...
August 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28667892/normal-aging-and-parkinson-s-disease-are-associated-with-the-functional-decline-of-distinct-frontal-striatal-circuits
#14
Aleksandra Gruszka, Adam Hampshire, Roger A Barker, Adrian M Owen
Impaired ability to shift attention between stimuli (i.e. shifting attentional 'set') is a well-established part of the dysexecutive syndrome in Parkinson's Disease (PD), nevertheless cognitive and neural bases of this deficit remain unclear. In this study, an fMRI-optimised variant of a classic paradigm for assessing attentional control (Hampshire and Owen 2006) was used to contrast activity in dissociable executive circuits in early-stage PD patients and controls. The results demonstrated that the neural basis of the executive performance impairments in PD is accompanied by hypoactivation within the striatum, anterior cingulate cortex (vACC), and inferior frontal sulcus (IFS) regions...
August 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28647831/alterations-in-regional-homogeneity-of-resting-state-brain-activity-in-fatigue-of-parkinson-s-disease
#15
Junyi Li, Yongsheng Yuan, Min Wang, Jiejin Zhang, Li Zhang, Siming Jiang, Jian Ding, Kezhong Zhang
Fatigue is a common complaint in patients with Parkinson's disease (PD). However, the neural bases of fatigue in PD remain uncertain. In this cross-sectional study, our aim was to study the change of the local brain function in PD patients with fatigue. Among 49 patients with PD, 17 of them had fatigue and the remaining 32 patients without fatigue, and 25 age- and gender-matched healthy controls were enrolled. All subjects were evaluated with Fatigue Severity Scale (FSS) and had a resting-state functional magnetic resonance imaging (rs-fMRI) scan...
June 24, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28597560/l-dopa-responsiveness-is-associated-with-distinctive-connectivity-patterns-in-advanced-parkinson-s-disease
#16
Harith Akram, Chengyuan Wu, Jonathan Hyam, Thomas Foltynie, Patricia Limousin, Enrico De Vita, Tarek Yousry, Marjan Jahanshahi, Marwan Hariz, Timothy Behrens, John Ashburner, Ludvic Zrinzo
BACKGROUND: Neuronal loss and dopamine depletion alter motor signal processing between cortical motor areas, basal ganglia, and the thalamus, resulting in the motor manifestations of Parkinson's disease. Dopamine replacement therapy can reverse these manifestations with varying degrees of improvement. METHODS: To evaluate functional connectivity in patients with advanced Parkinson's disease and changes in functional connectivity in relation to the degree of response to l-dopa, 19 patients with advanced Parkinson's disease underwent resting-state functional magnetic resonance imaging in the on-medication state...
June 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28566724/aberrant-intra-and-internetwork-functional-connectivity-in-depressed-parkinson-s-disease
#17
Luqing Wei, Xiao Hu, Yajing Zhu, Yonggui Yuan, Weiguo Liu, Hong Chen
Much is known concerning the underlying mechanisms of Parkinson's disease (PD) with depression, but our understanding of this disease at the neural-system level remains incomplete. This study used resting-state functional MRI (rs-fMRI) and independent component analysis (ICA) to investigate intrinsic functional connectivity (FC) within and between large-scale neural networks in 20 depressed PD (dPD) patients, 35 non-depressed PD (ndPD) patients, and 34 healthy controls (HC). To alleviate the influence caused by ICA model order selection, this work reported results from analyses at 2 levels (low and high model order)...
May 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28556242/cerebral-compensation-during-motor-function-in-friedreich-ataxia-the-image-frda-study
#18
Ian H Harding, Louise A Corben, Martin B Delatycki, Monique R Stagnitti, Elsdon Storey, Gary F Egan, Nellie Georgiou-Karistianis
BACKGROUND: Friedreich ataxia is characterized by progressive motor incoordination that is linked to peripheral, spinal, and cerebellar neuropathology. Cerebral abnormalities are also reported in Friedreich ataxia, but their role in disease expression remains unclear. METHODS: In this cross-sectional functional magnetic resonance imaging study, 25 individuals with Friedreich ataxia and 33 healthy controls performed simple (self-paced single-finger) and complex (visually cued multifinger) tapping tasks to respectively gauge basic and attentionally demanding motor behavior...
May 27, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28486506/an-fmri-study-into-emotional-processing-in-parkinson-s-disease-does-increased-medial-prefrontal-activation-compensate-for-striatal-dysfunction
#19
Anja J H Moonen, Peter H Weiss, Michael Wiesing, Ralph Weidner, Gereon R Fink, Jennifer S A M Reijnders, Wim M Weber, Albert F G Leentjens
BACKGROUND: Apart from a progressive decline of motor functions, Parkinson's disease (PD) is also characterized by non-motor symptoms, including disturbed processing of emotions. This study aims at assessing emotional processing and its neurobiological correlates in PD with the focus on how medicated Parkinson patients may achieve normal emotional responsiveness despite basal ganglia dysfunction. METHODS: Nineteen medicated patients with mild to moderate PD (without dementia or depression) and 19 matched healthy controls passively viewed positive, negative, and neutral pictures in an event-related blood oxygen level-dependent functional magnetic resonance imaging study (BOLD-fMRI)...
2017: PloS One
https://www.readbyqxmd.com/read/28484422/cortical-and-striatal-reward-processing-in-parkinson-s-disease-psychosis
#20
Sara Garofalo, Azucena Justicia, Gonzalo Arrondo, Anna O Ermakova, Pranathi Ramachandra, Carina Tudor-Sfetea, Trevor W Robbins, Roger A Barker, Paul C Fletcher, Graham K Murray
Psychotic symptoms frequently occur in Parkinson's disease (PD), but their pathophysiology is poorly understood. According to the National Institute of Health RDoc programme, the pathophysiological basis of neuropsychiatric symptoms may be better understood in terms of dysfunction of underlying domains of neurocognition in a trans-diagnostic fashion. Abnormal cortico-striatal reward processing has been proposed as a key domain contributing to the pathogenesis of psychotic symptoms in schizophrenia. This theory has received empirical support in the study of schizophrenia spectrum disorders and preclinical models of psychosis, but has not been tested in the psychosis associated with PD...
2017: Frontiers in Neurology
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