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Parkinson's fmri

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https://www.readbyqxmd.com/read/29928255/altered-whole-brain-and-network-based-functional-connectivity-in-parkinson-s-disease
#1
Laura J de Schipper, Anne Hafkemeijer, Jeroen van der Grond, Johan Marinus, Johanna M L Henselmans, Jacobus J van Hilten
Background: Functional imaging methods, such as resting-state functional magnetic resonance imaging, reflect changes in neural connectivity and may help to assess the widespread consequences of disease-specific network changes in Parkinson's disease. In this study we used a relatively new graph analysis approach in functional imaging: eigenvector centrality mapping. This model-free method, applied to all voxels in the brain, identifies prominent regions in the brain network hierarchy and detects localized differences between patient populations...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29917066/consistent-decreased-activity-in-the-putamen-in-parkinson-s-disease-a-meta-analysis-and-an-independent-validation-of-resting-state-fmri
#2
Jue Wang, Jia-Rong Zhang, Yu-Feng Zang, Tao Wu
Background: Resting-state functional magnetic resonance imaging (RS-fMRI) has frequently been used to investigate local spontaneous brain activity in Parkinson's disease (PD) in a whole-brain, voxel-wise manner. To quantitatively integrate these studies, we conducted a coordinate-based meta-analysis (CB meta-analysis), using the seed-based d mapping (SDM) method, on 15 studies that used amplitude of low frequency fluctuation (ALFF) and 11 studies that used regional homogeneity (ReHo)...
June 18, 2018: GigaScience
https://www.readbyqxmd.com/read/29887795/intra-and-inter-scanner-reliability-of-scaled-subprofile-model-of-principal-component-analysis-on-alff-in-resting-state-fmri-under-eyes-open-and-closed-conditions
#3
Li-Xia Yuan, Jian-Bao Wang, Na Zhao, Yuan-Yuan Li, Yilong Ma, Dong-Qiang Liu, Hong-Jian He, Jian-Hui Zhong, Yu-Feng Zang
Scaled Subprofile Model of Principal Component Analysis (SSM-PCA) is a multivariate statistical method and has been widely used in Positron Emission Tomography (PET). Recently, SSM-PCA has been applied to discriminate patients with Parkinson's disease and healthy controls with Amplitude of Low Frequency Fluctuation (ALFF) from Resting-State Functional Magnetic Resonance Imaging (RS-fMRI). As RS-fMRI scans are more readily available than PET scans, it is important to investigate the intra- and inter-scanner reliability of SSM-PCA in RS-fMRI...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29876270/resting-state-connectivity-in-neurodegenerative-disorders-is-there-potential-for-an-imaging-biomarker
#4
REVIEW
Christian Hohenfeld, Cornelius J Werner, Kathrin Reetz
Biomarkers in whichever modality are tremendously important in diagnosing of disease, tracking disease progression and clinical trials. This applies in particular for disorders with a long disease course including pre-symptomatic stages, in which only subtle signs of clinical progression can be observed. Magnetic resonance imaging (MRI) biomarkers hold particular promise due to their relative ease of use, cost-effectiveness and non-invasivity. Studies measuring resting-state functional MR connectivity have become increasingly common during recent years and are well established in neuroscience and related fields...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29850015/resting-state-fmri-a-valuable-tool-for-studying-cognitive-dysfunction-in-pd
#5
REVIEW
Kai Li, Wen Su, Shu-Hua Li, Ying Jin, Hai-Bo Chen
Cognitive impairment is a common disabling symptom in PD. Unlike motor symptoms, the mechanism underlying cognitive dysfunction in Parkinson's disease (PD) remains unclear and may involve multiple pathophysiological processes. Resting state functional magnetic resonance imaging (rs-fMRI) is a fast-developing research field, and its application in cognitive impairments in PD is rapidly growing. In this review, we summarize rs-fMRI studies on cognitive function in PD and discuss the strong potential of rs-fMRI in this area...
2018: Parkinson's Disease
https://www.readbyqxmd.com/read/29764720/altered-somatosensory-processing-in-parkinson-s-disease-and-modulation-by-dopaminergic-medications
#6
Aimee J Nelson, Tasnuva Hoque, Carolyn Gunraj, Robert Chen
BACKGROUND: Somatosensory abnormalities contribute to the pathophysiology of Parkinson's disease (PD). The goal of this study was to identify abnormalities in the tactile-evoked activation of the somatosensory and motor cortices in PD, and in a sensorimotor circuit that traverses both of these cortical loci. The second goal was to investigate the impact of dopaminergic medication on these measures. METHODS: Individuals with PD (n = 10, age 61 ± 8 years) and aged-matched controls (n = 11, age 52...
May 7, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29754837/effects-of-exercise-on-gait-and-motor-imagery-in-people-with-parkinson-disease-and-freezing-of-gait
#7
Peter S Myers, Marie E McNeely, Kristen A Pickett, Ryan P Duncan, Gammon M Earhart
INTRODUCTION: Exercise improves gait in Parkinson disease (PD), but whether exercise differentially affects people with PD with (freezers) and without freezing of gait (non-freezers) remains unclear. This study examines exercise's effects on gait performance, neural correlates related to these effects, and potential neural activation differences between freezers and non-freezers during motor imagery (MI) of gait. METHODS: Thirty-seven participants from a larger exercise intervention completed behavioral assessments and functional magnetic resonance imaging (fMRI) scans before and after a 12-week exercise intervention...
May 8, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29728527/disrupted-hypothalamic-functional-connectivity-in-patients-with-pd-and-autonomic-dysfunction
#8
Eran Dayan, Miriam Sklerov, Nina Browner
OBJECTIVE: To test whether symptoms of autonomic dysfunction in Parkinson disease (PD) are associated with alterations in intrinsic hypothalamic functional connectivity, given the regulatory role of the hypothalamus (HTH) in the autonomic nervous system. METHODS: Resting-state fMRI scans from patients with PD were analyzed, comparing patients with the highest (n = 24) and lowest (n = 28) quartile scores in a questionnaire assessing autonomic dysfunction in PD (Scales for Outcomes in Parkinson's Disease-Autonomic [SCOPA-AUT]), obtained from a larger pool of patients (n = 93)...
June 5, 2018: Neurology
https://www.readbyqxmd.com/read/29722099/deficient-supplementary-motor-area-at-rest-neural-basis-of-limb-kinetic-deficits-in-parkinson-s-disease
#9
Stefanie Kübel, Katharina Stegmayer, Tim Vanbellingen, Sebastian Walther, Stephan Bohlhalter
Parkinson's disease (PD) patients frequently suffer from limb kinetic apraxia (LKA) affecting quality of life. LKA denotes an impairment of precise and independent finger movements beyond bradykinesia, which is reliably assessed by coin rotation (CR) task. BOLD fMRI detected activation of a left inferior parietal-premotor praxis network in PD during CR. Here, we explored which network site is most critical for LKA using arterial spin labeling (ASL). Based on a hierarchical model, we hypothesized that LKA would predominantly affect the functional integrity of premotor areas including supplementary motor areas (SMA)...
May 2, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29606606/gender-specific-effect-of-uric-acid-on-resting-state-functional-networks-in-de-novo-parkinson-s-disease
#10
Yoonju Lee, Yeong-Hun Park, Jae Jung Lee, Young H Sohn, Jong-Min Lee, Phil Hyu Lee
INTRODUCTION: The pattern of resting-state networks is influenced by several factors besides the underlying pathological changes of Parkinson's disease (PD). Uric acid (UA), as an antioxidant, has a neuroprotective property against PD-related microenvironment; however, this effect would be gender-specific. We aimed to evaluate a gender-sensitive resting-state networks (RSN) according to the UA level in drug naïve de novo patients with PD to elucidate the role of antioxidant in cortical functional networks of PD...
March 26, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29602542/decreased-interhemispheric-homotopic-connectivity-in-parkinson-s-disease-patients-with-freezing-of-gait-a-resting-state-fmri-study
#11
Junyi Li, Yongsheng Yuan, Min Wang, Jiejin Zhang, Li Zhang, Siming Jiang, Xixi Wang, Jian Ding, Kezhong Zhang
INTRODUCTION: Freezing of gait is a common complaint in patients with Parkinson's disease (PD). However, the neural bases of freezing of gait in PD remain uncertain. Existing studies on PD patients with freezing of gait (PD-FOG+) have reported damage of the corpus callosum, the largest commissural bundle of the brain. Thus, in this study we explored homotopic connectivity to investigate FOG-related interehemispheric alterations METHODS: A total of 21 PD-FOG + patients, 33 PD patients without freezing of gait (PD-FOG-), and 24 matched healthy controls were recruited...
March 26, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29593637/structural-and-functional-brain-patterns-of-non-motor-syndromes-in-parkinson-s-disease
#12
REVIEW
Tino Prell
Parkinson's disease (PD) is a common, progressive and multisystem neurodegenerative disorder characterized by motor and non-motor symptoms. Advanced magnetic resonance imaging, positron emission tomography, and functional magnetic resonance imaging can render the view toward understanding the neural basis of these non-motor syndromes, as they help to understand the underlying pathophysiological abnormalities. This review provides an up-to-date description of structural and functional brain alterations in patients with PD with cognitive deficits, visual hallucinations, fatigue, impulsive behavior disorders, sleep disorders, and pain...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29567424/altered-intrinsic-brain-functional-connectivity-in-drug-na%C3%A3-ve-parkinson-s-disease-patients-with-lrrk2-mutations
#13
Yanbing Hou, Chunyan Luo, Jing Yang, Ruwei Ou, Wei Song, Yongping Chen, Qiyong Gong, Huifang Shang
BACKGROUND: Leucine-rich repeat kinase 2 (LRRK2) has been recently identified as a causative gene of Parkinson's disease (PD), and the LRRK2 R1628P and G2385R mutations are common in ethnic Han-Chinese PD patients. However, the pathogenic mechanism of LRRK2 mutations in PD remains largely unknown. METHODS: Resting-state functional MRI (fMRI) was used to assess the functional connectivity (FC) of the striatal subregions of 11 ethnic Han-Chinese drug-naïve PD patients with the LRRK2 R1628P or G2385R mutations, 11 ethnic Han-Chinese drug-naïve PD patients without such mutations, and 22 healthy control (HC) subjects...
May 14, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29541016/galvanic-vestibular-stimulation-gvs-augments-deficient-pedunculopontine-nucleus-ppn-connectivity-in-mild-parkinson-s-disease-fmri-effects-of-different-stimuli
#14
Jiayue Cai, Soojin Lee, Fang Ba, Saurabh Garg, Laura J Kim, Aiping Liu, Diana Kim, Z Jane Wang, Martin J McKeown
Falls and balance difficulties remain a major source of morbidity in Parkinson's Disease (PD) and are stubbornly resistant to therapeutic interventions. The mechanisms of gait impairment in PD are incompletely understood but may involve changes in the Pedunculopontine Nucleus (PPN) and its associated connections. We utilized fMRI to explore the modulation of PPN connectivity by Galvanic Vestibular Stimulation (GVS) in healthy controls ( n = 12) and PD subjects even without overt evidence of Freezing of Gait (FOG) while on medication ( n = 23)...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29530489/abnormal-ventral-tegmental-area-anterior-cingulate-cortex-connectivity-in-parkinson-s-disease-with-depression
#15
Luqing Wei, Xiao Hu, Yonggui Yuan, Weiguo Liu, Hong Chen
Neuropathology suggests that Parkinson's disease (PD) with depression may involve a progressive degeneration of the nigrostriatal and mesocorticolimbic dopaminergic systems. Previous positron emission tomography (PET) and single-photon emission computed tomography (SPECT) studies have shown that dopamine changes in individual brain regions constituting the nigrostriatal and mesocorticolimbic circuits are associated with depression in PD. However, few studies have been conducted on the circuit-level alterations in this disease...
March 9, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29527489/dynamic-functional-connectivity-in-parkinson-s-disease-patients-with-mild-cognitive-impairment-and-normal-cognition
#16
María Díez-Cirarda, Antonio P Strafella, Jinhee Kim, Javier Peña, Natalia Ojeda, Alberto Cabrera-Zubizarreta, Naroa Ibarretxe-Bilbao
The objective was to assess dynamic functional connectivity (FC) and local/global connectivity in Parkinson's disease (PD) patients with mild cognitive impairment (PD-MCI) and with normal cognition (PD-NC). The sample included 35 PD patients and 26 healthy controls (HC). Cognitive assessment followed an extensive neuropsychological battery. For resting-state functional MRI (rs-fMRI) analysis, independent component analysis (ICA) was performed and components were located in 7 networks: Subcortical (SC), Auditory (AUD), Somatomotor (SM), visual (VI), cognitive-control (CC), default-mode (DMN), and cerebellar (CB)...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29501966/levodopa-improves-response-inhibition-and-enhances-striatal-activation-in-early-stage-parkinson-s-disease
#17
Peter Manza, Guy Schwartz, Mala Masson, Sarah Kann, Nora D Volkow, Chiang-Shan R Li, Hoi-Chung Leung
Dopaminergic medications improve the motor symptoms of Parkinson's disease (PD), but their effect on response inhibition, a critical executive function, remains unclear. Previous studies primarily enrolled patients in more advanced stages of PD, when dopaminergic medication loses efficacy, and patients were typically on multiple medications. Here, we recruited 21 patients in early-stage PD on levodopa monotherapy and 37 age-matched controls to perform the stop-signal task during functional magnetic resonance imaging...
June 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29501577/correlations-between-csf-proteins-and-spontaneous-neuronal-activity-in-parkinson-s-disease
#18
Tao Guo, Xiaojun Guan, Qiaoling Zeng, Min Xuan, Quanquan Gu, Xiaojun Xu, Minming Zhang
The relationship between cerebrospinal fluid (CSF) proteins and brain function in Parkinson's disease (PD) is not explained clearly. We investigated the correlations between CSF proteins and spontaneous neuronal activity in PD patients via fractional amplitude of low-frequency fluctuation (fALFF) using the Parkinson's Progression Markers Initiative database. Twenty-eight PD patients underwent resting-state functional magnetic resonance imaging in "off" status and lumbar puncture within a month. Correlation analyses between CSF proteins and fALFF value in whole brain as well as clinical assessment scores were performed...
April 23, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29500931/abnormal-resting-state-functional-connectivity-in-posterior-cingulate-cortex-of-parkinson-s-disease-with-mild-cognitive-impairment-and-dementia
#19
Zhou-Wei Zhan, Li-Zhen Lin, Er-Han Yu, Jia-Wei Xin, Lin Lin, Hai-Long Lin, Qin-Yong Ye, Xiao-Chun Chen, Xiao-Dong Pan
OBJECTIVE: To investigate changes in the functional connectivity (FC) pattern in the posterior cingulate cortex (PCC) of Parkinson's disease (PD) patients with mild cognitive impairment and dementia by employing resting-state functional magnetic resonance imaging (RS-fMRI). METHODS: Twenty-seven PD patients with different cognitive status and 9 healthy control subjects (control group) were enrolled for RS-fMRI. The RS-fMRI data were analyzed with DPARSF and REST software...
March 3, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29481966/value-encoding-in-the-globus-pallidus-fmri-reveals-an-interaction-effect-between-reward-and-dopamine-drive
#20
Vincenzo G Fiore, Tobias Nolte, Francesco Rigoli, Peter Smittenaar, Xiaosi Gu, Raymond J Dolan
The external part of the globus pallidus (GPe) is a core nucleus of the basal ganglia (BG) whose activity is disrupted under conditions of low dopamine release, as in Parkinson's disease. Current models assume decreased dopamine release in the dorsal striatum results in deactivation of dorsal GPe, which in turn affects motor expression via a regulatory effect on other nuclei of the BG. However, recent studies in healthy and pathological animal models have reported neural dynamics that do not match with this view of the GPe as a relay in the BG circuit...
June 2018: NeuroImage
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