keyword
MENU ▼
Read by QxMD icon Read
search

Parkinson's fmri

keyword
https://www.readbyqxmd.com/read/29432300/dopamine-modulates-striatal-response-to-reward-and-punishment-in-patients-with-parkinson-s-disease-a-pharmacological-challenge-fmri-study
#1
Miklos Argyelan, Mohammad Herzallah, Wataru Sako, Ivana DeLucia, Deepak Sarpal, An Vo, Toni Fitzpatrick, Ahmed A Moustafa, David Eidelberg, Mark Gluck
It is well established that Parkinson's disease leads to impaired learning from reward and enhanced learning from punishment. The administration of dopaminergic medications reverses this learning pattern. However, few studies have investigated the neural underpinnings of these cognitive processes. In this study, using fMRI, we tested a group of Parkinson's disease patients on and off dopaminergic medications and matched healthy individuals. All individuals completed an fMRI cognitive task that dissociates feedback learning from reward versus punishment...
February 9, 2018: Neuroreport
https://www.readbyqxmd.com/read/29414287/symbol-digit-modalities-test-adaptation-for-magnetic-resonance-imaging-environment-a-systematic-review-and-meta-analysis
#2
REVIEW
P H R Silva, C T Spedo, A A Barreira, R F Leoni
BACKGROUND: The Symbol Digit Modalities Test (SDMT) is widely used for cognitive evaluation of information processing speed (IPS), required in many cognitive operations. Despite being unspecific for different neurological disorders, it is sensitive to assess impaired performance related to stroke, Parkinson's disease, traumatic brain injury, and multiple sclerosis. However, in addition to evaluate the presence and severity of IPS impairment, it is of interest to determine the localization and integration of brain regions responsible for the functions assessed by the SDMT...
January 25, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29403348/training-for-micrographia-alters-neural-connectivity-in-parkinson-s-disease
#3
Evelien Nackaerts, Jochen Michely, Elke Heremans, Stephan P Swinnen, Bouwien C M Smits-Engelsman, Wim Vandenberghe, Christian Grefkes, Alice Nieuwboer
Despite recent advances in clarifying the neural networks underlying rehabilitation in Parkinson's disease (PD), the impact of prolonged motor learning interventions on brain connectivity in people with PD is currently unknown. Therefore, the objective of this study was to compare cortical network changes after 6 weeks of visually cued handwriting training (= experimental) with a placebo intervention to address micrographia, a common problem in PD. Twenty seven early Parkinson's patients on dopaminergic medication performed a pre-writing task in both the presence and absence of visual cues during behavioral tests and during fMRI...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29392456/distinct-manifestation-of-cognitive-deficits-associate-with-different-resting-state-network-disruptions-in-non-demented-patients-with-parkinson-s-disease
#4
Kazuya Kawabata, Hirohisa Watanabe, Kazuhiro Hara, Epifanio Bagarinao, Noritaka Yoneyama, Aya Ogura, Kazunori Imai, Michihito Masuda, Takamasa Yokoi, Reiko Ohdake, Yasuhiro Tanaka, Takashi Tsuboi, Tomohiko Nakamura, Masaaki Hirayama, Mizuki Ito, Naoki Atsuta, Satoshi Maesawa, Shinji Naganawa, Masahisa Katsuno, Gen Sobue
Cognitive deficits in Parkinson's disease (PD) are heterogeneous entities, but a relationship between the heterogeneity of cognitive deficits and resting-state network (RSN) changes remains elusive. In this study, we examined five sub-domain scores according to Addenbrooke's Cognitive Examination-Revised (ACE-R) for the cognitive evaluation and classification of 72 non-demented patients with PD. Twenty-eight patients were classified as PD with normal cognition (PD-NC). The remaining 44 were subdivided into the following 2 groups using a hierarchical cluster analysis: 20 with a predominant decrease in memory (PD with amnestic cognitive deficits: PD-A) and 24 with good memory who exhibited a decrease in other sub-domains (PD with non-amnestic cognitive deficits: PD-NA)...
February 1, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29382820/similar-neural-responses-predict-friendship
#5
Carolyn Parkinson, Adam M Kleinbaum, Thalia Wheatley
Human social networks are overwhelmingly homophilous: individuals tend to befriend others who are similar to them in terms of a range of physical attributes (e.g., age, gender). Do similarities among friends reflect deeper similarities in how we perceive, interpret, and respond to the world? To test whether friendship, and more generally, social network proximity, is associated with increased similarity of real-time mental responding, we used functional magnetic resonance imaging to scan subjects' brains during free viewing of naturalistic movies...
January 30, 2018: Nature Communications
https://www.readbyqxmd.com/read/29381889/alteration-in-the-local-and-global-functional-connectivity-of-resting-state-networks-in-parkinson-s-disease
#6
Maryam Ghahremani, Jaejun Yoo, Sun Ju Chung, Kwangsun Yoo, Jong C Ye, Yong Jeong
OBJECTIVE: Parkinson's disease (PD) is a neurodegenerative disorder that mainly leads to the impairment of patients' motor function, as well as of cognition, as it progresses. This study tried to investigate the impact of PD on the resting state functional connectivity of the default mode network (DMN), as well as of the entire brain. METHODS: Sixty patients with PD were included and compared to 60 matched normal control (NC) subjects. For the local connectivity analysis, the resting state fMRI data were analyzed by seed-based correlation analyses, and then a novel persistent homology analysis was implemented to examine the connectivity from a global perspective...
January 2018: Journal of Movement Disorders
https://www.readbyqxmd.com/read/29379873/a-common-function-of-basal-ganglia-cortical-circuits-subserving-speed-in-both-motor-and-cognitive-domains
#7
Takashi Hanakawa, Andrew M Goldfine, Mark Hallett
Distinct regions of the frontal cortex connect with their basal ganglia and thalamic counterparts, constituting largely segregated basal ganglia-thalamo-cortical (BTC) circuits. However, any common role of the BTC circuits in different behavioral domains remains unclear. Indeed, whether dysfunctional motor and cognitive BTC circuits are responsible for motor slowing and cognitive slowing, respectively, in Parkinson's disease (PD) is a matter of debate. Here, we used an effortful behavioral paradigm in which the effects of task rate on accuracy were tested in movement, imagery, and calculation tasks in humans...
November 2017: ENeuro
https://www.readbyqxmd.com/read/29355770/incorporating-spatial-constraint-in-co-activation-pattern-analysis-to-explore-the-dynamics-of-resting-state-networks-an-application-to-parkinson-s-disease
#8
Xiaowei Zhuang, Ryan R Walsh, Karthik Sreenivasan, Zhengshi Yang, Virendra Mishra, Dietmar Cordes
The dynamics of the brain's intrinsic networks have been recently studied using co-activation pattern (CAP) analysis. The CAP method relies on few model assumptions and CAP-based measurements provide quantitative information of network temporal dynamics. One limitation of existing CAP-related methods is that the computed CAPs share considerable spatial overlap that may or may not be functionally distinct relative to specific network dynamics. To more accurately describe network dynamics with spatially distinct CAPs, and to compare network dynamics between different populations, a novel data-driven CAP group analysis method is proposed in this study...
January 17, 2018: NeuroImage
https://www.readbyqxmd.com/read/29304050/severe-hyposmia-and-aberrant-functional-connectivity-in-cognitively-normal-parkinson-s-disease
#9
Noritaka Yoneyama, Hirohisa Watanabe, Kazuya Kawabata, Epifanio Bagarinao, Kazuhiro Hara, Takashi Tsuboi, Yasuhiro Tanaka, Reiko Ohdake, Kazunori Imai, Michihito Masuda, Tatsuya Hattori, Mizuki Ito, Naoki Atsuta, Tomohiko Nakamura, Masaaki Hirayama, Satoshi Maesawa, Masahisa Katsuno, Gen Sobue
OBJECTIVE: Severe hyposmia is a risk factor of dementia in Parkinson's disease (PD), while the underlying functional connectivity (FC) and brain volume alterations in PD patients with severe hyposmia (PD-SH) are unclear. METHODS: We examined voxel-based morphometric and resting state functional magnetic resonance imaging findings in 15 cognitively normal PD-SH, 15 cognitively normal patients with PD with no/mild hyposmia (PD-N/MH), and 15 healthy controls (HCs)...
2018: PloS One
https://www.readbyqxmd.com/read/29273705/high-intensity-exercise-acutely-increases-substantia-nigra-and-prefrontal-brain-activity-in-parkinson-s-disease
#10
Neil A Kelly, Kimberly H Wood, Jane B Allendorfer, Matthew P Ford, C Scott Bickel, Jon Marstrander, Amy W Amara, Thomas Anthony, Marcas M Bamman, Frank M Skidmore
BACKGROUND Pathologic alterations in resting-state brain activity patterns exist among individuals with Parkinson's disease (PD). Since physical exercise alters resting-state brain activity in non-PD populations and improves PD symptoms, we assessed the acute effect of exercise on resting-state brain activity in exercise-trained individuals with PD. MATERIAL AND METHODS Resting-state functional magnetic resonance imaging (fMRI) was collected twice for 17 PD participants at the conclusion of an exercise intervention...
December 23, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29273534/altered-functional-connectivity-of-the-subthalamic-nucleus-during-self-initiated-movement-in-parkinson-s-disease
#11
Qian Jia, Linlin Gao, Jiarong Zhang, Tao Wu, Piu Chan
BACKGROUND AND PURPOSE: Patients with Parkinson's disease (PD) have difficulty performing self-initiated movements. The neural mechanism of this deficiency remains unclear. In the present study, we used functional magnetic resonance imaging (fMRI) to investigate the functional connectivity of the subthalamic nucleus (STN) during self-initiated movement in patients with PD. MATERIALS AND METHODS: fMRI were acquired from patients with PD and age- and sex-matched healthy control subjects during a self-initiated right hand tapping task...
December 19, 2017: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/29243004/altered-effective-connectivity-contributes-to-micrographia-in-patients-with-parkinson-s-disease-and-freezing-of-gait
#12
Evelien Nackaerts, Alice Nieuwboer, Sanne Broeder, Stephan Swinnen, Wim Vandenberghe, Elke Heremans
Recently, it was shown that patients with Parkinson's disease (PD) and freezing of gait (FOG) can also experience freezing episodes during handwriting and present writing problems outside these episodes. So far, the neural networks underlying increased handwriting problems in subjects with FOG are unclear. This study used dynamic causal modeling of fMRI data to investigate neural network dynamics underlying freezing-related handwriting problems and how these networks changed in response to visual cues. Twenty-seven non-freezers and ten freezers performed a pre-writing task with and without visual cues in the scanner with their right hand...
December 14, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29222835/effective-network-of-deep-brain-stimulation-of-subthalamic-nucleus-with-bimodal-positron-emission-tomography-functional-magnetic-resonance-imaging-in-parkinson-s-disease
#13
Hui-Min Chen, Zhi-Qiang Sha, Hui-Zi Ma, Yong He, Tao Feng
AIMS: Deep brain stimulation of the subthalamic nucleus (STN-DBS) has become an effective treatment strategy for patients with Parkinson's disease. However, the biological mechanism underlying DBS treatment remains poorly understood. METHOD: In this study, we investigated how STN-DBS modulated the brain network using a bimodal positron emission tomography (PET)/functional magnetic resonance imaging (fMRI) dataset. We first performed an activation likelihood estimation meta-analysis of 13 PET/SPECT studies concerning STN-DBS effects on resting-state brain activity in Parkinson's disease...
February 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29182621/exploring-the-reproducibility-of-functional-connectivity-alterations-in-parkinson-s-disease
#14
Liviu Badea, Mihaela Onu, Tao Wu, Adina Roceanu, Ovidiu Bajenaru
Since anatomic MRI is presently not able to directly discern neuronal loss in Parkinson's Disease (PD), studying the associated functional connectivity (FC) changes seems a promising approach toward developing non-invasive and non-radioactive neuroimaging markers for this disease. While several groups have reported such FC changes in PD, there are also significant discrepancies between studies. Investigating the reproducibility of PD-related FC changes on independent datasets is therefore of crucial importance...
2017: PloS One
https://www.readbyqxmd.com/read/29143414/central-pain-processing-in-drug-na%C3%A3-ve-pain-free-patients-with-parkinson-s-disease
#15
Alessandro Tessitore, Antonio Russo, Rosa De Micco, Michele Fratello, Giuseppina Caiazzo, Alfonso Giordano, Mario Cirillo, Gioacchino Tedeschi, Fabrizio Esposito
BACKGROUND: Despite its clinical relevance, the pathophysiology of pain in Parkinson's disease (PD) is still largely unknown, and both central and peripheral mechanisms have been invoked. OBJECTIVES: To investigate whether central pain processing is altered in "drug-naive" pain-free PD (dnPD) patients. METHODS: Using event-related functional MRI (fMRI), functional response to forearm heat stimulation (FHS) at two different intensities (41°C and 53°C) was investigated in 20 pain-free dnPD patients, compared with 18 healthy controls (HCs)...
November 15, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/29124784/dysfunction-in-emotion-processing-underlies-functional-psychogenic-dystonia
#16
Alberto J Espay, Thomas Maloney, Jennifer Vannest, Matthew M Norris, James C Eliassen, Erin Neefus, Jane B Allendorfer, Robert Chen, Jerzy P Szaflarski
OBJECTIVE: We sought to determine whether abnormalities in emotion processing underlie functional (psychogenic) dystonia, one of the most common functional movement disorders. METHODS: Motor and emotion circuits were examined in 12 participants with functional dystonia, 12 with primary organic dystonia, and 25 healthy controls using functional magnetic resonance imaging at 4T and a finger-tapping task (motor task), a basic emotion-recognition task (emotional faces task), and an intense-emotion stimuli task...
November 10, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29113397/altered-putamen-functional-connectivity-is-associated-with-anxiety-disorder-in-parkinson-s-disease
#17
Xixi Wang, Junyi Li, Yongsheng Yuan, Min Wang, Jian Ding, Jiejin Zhang, Lin Zhu, Yuting Shen, Hui Zhang, Kezhong Zhang
In this study, we used resting state-functional magnetic resonance imaging (rs-fMRI) to explore altered putamen functional connectivity (FC) in Parkinson's disease patients with anxiety disorder. We divided 65 Parkinson's disease patients into anxiety (PD-A; n=18) and non-anxiety (PD-NA; n=45) groups based on a Hamilton Anxiety Rating Scale cutoff score of 12. The PD-A patients exhibited altered putamen FC with cortical and subcortical regions. The PD-A patients showed enhanced putamen FC with the caudatum, which correlated with increased emotional processing during anxiety...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29070942/odor-selectivity-of-hyposmia-and-cognitive-impairment-in-patients-with-parkinson-s-disease
#18
Cheng-Jie Mao, Fen Wang, Ju-Ping Chen, Ya-Ping Yang, Jing Chen, Juan-Ying Huang, Chun-Feng Liu
OBJECTIVE: Hyposmia is one of the earliest non-motor features of Parkinson's disease (PD) and can precede the onset of motor symptoms by years. Most of the current olfactory detection tests are targeted at Western populations. The exact relationship between hyposmia and cognitive impairment is unknown. The purpose of the study was to find bromines that can effectively identify olfactory dysfunction and investigate the relationship between hyposmia and cognitive function in early, non-demented, drug-naïve patients with PD in the People's Republic of China...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29065697/altered-functional-connectivity-between-precuneus-and-motor-systems-in-parkinson-s-disease-patients
#19
Raissa Benocci Thibes, Natalia P Novaes, Leandro T Lucato, Kenia R Campanholo, Luciano M Melo, Claudia C Leite, Edson Amaro, Egberto Reis Barbosa, Edson Bor-Seng-Shu, Ellison Fernando Cardoso, João Ricardo Sato
INTRODUCTION: Parkinson's Disease (PD) is a neurodegenerative disorder that affects motor skills and cognition. As brain structure and function are compromised, functional magnetic resonance imaging (fMRI) can be a helpful tool to further investigate how intrinsic connectivity is impaired on the disease. The precuneus and medial prefrontal cortex are hub regions involved on the Default Mode Network, a system which is active during rest and related to cognitive processes. We hypothesized that PD patients would present a decrease in functional connectivity amongst these two regions and the rest of the brain...
October 25, 2017: Brain Connectivity
https://www.readbyqxmd.com/read/29053835/abnormal-intrinsic-brain-functional-network-dynamics-in-parkinson-s-disease
#20
Jinhee Kim, Marion Criaud, Sang Soo Cho, María Díez-Cirarda, Alexander Mihaescu, Sarah Coakeley, Christine Ghadery, Mikaeel Valli, Mark F Jacobs, Sylvain Houle, Antonio P Strafella
No abstract text is available yet for this article.
November 1, 2017: Brain: a Journal of Neurology
keyword
keyword
41112
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"