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Parkinson's fmri

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https://www.readbyqxmd.com/read/27911020/changes-in-resting-state-connectivity-in-musicians-with-embouchure-dystonia
#1
Bernhard Haslinger, Jonas Noé, Eckart Altenmüller, Valentin Riedl, Claus Zimmer, Tobias Mantel, Christian Dresel
OBJECTIVE: Embouchure dystonia is a highly disabling task-specific dystonia in professional brass musicians leading to spasms of perioral muscles while playing the instrument. As they are asymptomatic at rest, resting-state functional magnetic resonance imaging in these patients can reveal changes in functional connectivity within and between brain networks independent from dystonic symptoms. METHODS: We therefore compared embouchure dystonia patients to healthy musicians with resting-state functional magnetic resonance imaging in combination with independent component analyses...
December 2, 2016: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/27880010/abnormal-baseline-brain-activity-in-parkinson-s-disease-with-and-without-rem-sleep-behavior-disorder-a-resting-state-functional-mri-study
#2
Dan Li, Peiyu Huang, Yufeng Zang, Yuting Lou, Zhidong Cen, Quanquan Gu, Min Xuan, Fei Xie, Zhiyuan Ouyang, Bo Wang, Minming Zhang, Wei Luo
PURPOSE: To investigate the differences in spontaneous brain activity between Parkinson's disease (PD) patients with rapid eye movement sleep behavior disorder (RBD), PD patients without RBD, and normal controls, which may shed new light on the neural mechanism of RBD. MATERIALS AND METHODS: Eighteen PD patients with RBD, 16 patients without RBD, and 19 age- and gender-matched normal controls underwent clinical assessment and functional magnetic resonance imaging (fMRI) with a 3...
November 23, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27859960/cognitive-phenotypes-in-parkinson-s-disease-differ-in-terms-of-brain-network-organization-and-connectivity
#3
Renaud Lopes, Christine Delmaire, Luc Defebvre, Anja J Moonen, Annelien A Duits, Paul Hofman, Albert F G Leentjens, Kathy Dujardin
Cognitive deficits are common in Parkinson's disease and we suspect that dysfunctions of connected brain regions can be the source of these deficits. The aim of the present study was to investigate changes in whole-brain intrinsic functional connectivity according to differences in cognitive profiles in Parkinson's disease. 119 participants were enrolled and divided into four groups according to their cognitive phenotypes (determined by a cluster analysis): (i) 31 cognitively intact patients (G1), (ii) 31 patients with only slight mental slowing (G2), (iii) 43 patients with mild to moderate deficits mainly in executive functions (G3), (iv) 14 patients with severe deficits in all cognitive domains (G4-5)...
November 17, 2016: Human Brain Mapping
https://www.readbyqxmd.com/read/27859903/corticostriatal-connectivity-fingerprints-probability-maps-based-on-resting-state-functional-connectivity
#4
Ellen Jaspers, Joshua H Balsters, Pegah Kassraian Fard, Dante Mantini, Nicole Wenderoth
Over the last decade, structure-function relationships have begun to encompass networks of brain areas rather than individual structures. For example, corticostriatal circuits have been associated with sensorimotor, limbic, and cognitive information processing, and damage to these circuits has been shown to produce unique behavioral outcomes in Autism, Parkinson's Disease, Schizophrenia and healthy ageing. However, it remains an open question how abnormal or absent connectivity can be detected at the individual level...
November 12, 2016: Human Brain Mapping
https://www.readbyqxmd.com/read/27848084/default-mode-network-connectivity-in-cognitively-unimpaired-drug-na%C3%A3-ve-patients-with-rigidity-dominant-parkinson-s-disease
#5
Yanbing Hou, Chunyan Luo, Jing Yang, Ruwei Ou, Wanglin Liu, Wei Song, Qiyong Gong, Huifang Shang
Parkinson's disease (PD) with akinetic rigidity (PDAR) is more likely to develop cognitive deficits compared to PD with tremor-dominant symptoms (PDTD). The default mode network (DMN) is highly relevant for cognitive processes, so this study tested the functional connectivity (FC) of DMN in cognitively unimpaired PDAR patients. Resting-state fMRI data were collected in 21 cognitively unimpaired early stage drug-naïve patients with PDAR and 21 healthy controls (HC). PD patients were matched closely to HCs for demographic and cognitive variables...
November 15, 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27833548/dysfunction-of-the-default-mode-network-in-drug-na%C3%A3-ve-parkinson-s-disease-with-mild-cognitive-impairments-a-resting-state-fmri-study
#6
Yanbing Hou, Jing Yang, Chunyan Luo, Wei Song, Ruwei Ou, Wanglin Liu, Qiyong Gong, Huifang Shang
Objective: Cognitive impairments are common in Parkinson's disease (PD) and can even occur in the early stages. The default mode network (DMN) is highly relevant for cognitive processes; however, it remains largely unknown if changes in the DMN connectivity are related to the cognitive decline in drug-naïve early stage PD patients with a mild cognitive impairment (MCI). This study used resting-state functional MRI (fMRI) to explore the brain connectivity of the DMN in early stage drug-naïve PD patients with MCI...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27809791/the-parkin-play-study-protocol-of-a-phase-ii-randomized-controlled-trial-to-assess-the-effects-of-a-health-game-on-cognition-in-parkinson-s-disease
#7
Sjors C F van de Weijer, Annelien A Duits, Bastiaan R Bloem, Roy P Kessels, Jacobus F A Jansen, Sebastian Köhler, Gerrit Tissingh, Mark L Kuijf
BACKGROUND: In Parkinson's disease (PD), cognitive impairment is an important non-motor symptom heralding the development of dementia. Effective treatments to slow down the rate of cognitive decline in PD patients with mild cognitive impairment are lacking. Here, we describe the design of the Parkin'Play study, which assesses the effects of a cognitive health game intervention on cognition in PD. METHODS/DESIGN: This study is a multicentre, phase-II, open-randomized clinical trial that aims to recruit 222 PD patients with mild cognitive impairment...
November 3, 2016: BMC Neurology
https://www.readbyqxmd.com/read/27800157/the-study-of-brain-functional-connectivity-in-parkinson-s-disease
#8
REVIEW
Lin-Lin Gao, Tao Wu
Parkinson's disease (PD) is a neurodegenerative disorder primarily affecting the aging population. The neurophysiological mechanisms underlying parkinsonian symptoms remain unclear. PD affects extensive neural networks and a more thorough understanding of network disruption will help bridge the gap between known pathological changes and observed clinical presentations in PD. Development of neuroimaging techniques, especially functional magnetic resonance imaging, allows for detection of the functional connectivity of neural networks in patients with PD...
2016: Translational Neurodegeneration
https://www.readbyqxmd.com/read/27788143/brain-connectivity-changes-in-autosomal-recessive-parkinson-disease-a-model-for-the-sporadic-form
#9
Elena Makovac, Mara Cercignani, Laura Serra, Mario Torso, Barbara Spanò, Simona Petrucci, Lucia Ricciardi, Monia Ginevrino, Carlo Caltagirone, Anna Rita Bentivoglio, Enza Maria Valente, Marco Bozzali
Biallelic genetic mutations in the Park2 and PINK1 genes are frequent causes of autosomal recessive PD. Carriers of single heterozygous mutations may manifest subtle signs of disease, thus providing a unique model of preclinical PD. One emerging hypothesis suggests that non-motor symptom of PD, such as cognitive impairment may be due to a distributed functional disruption of various neuronal circuits. Using resting-state functional MRI (RS-fMRI), we tested the hypothesis that abnormal connectivity within and between brain networks may account for the patients' cognitive status...
2016: PloS One
https://www.readbyqxmd.com/read/27778161/brain-plasticity-in-parkinson-s-disease-with-freezing-of-gait-induced-by-action-observation-training
#10
Federica Agosta, Roberto Gatti, Elisabetta Sarasso, Maria Antonietta Volonté, Elisa Canu, Alessandro Meani, Lidia Sarro, Massimiliano Copetti, Erik Cattrysse, Eric Kerckhofs, Giancarlo Comi, Andrea Falini, Massimo Filippi
Gait disorders represent a therapeutic challenge in Parkinson's disease (PD). This study investigated the efficacy of 4-week action observation training (AOT) on disease severity, freezing of gait and motor abilities in PD, and evaluated treatment-related brain functional changes. 25 PD patients with freezing of gait were randomized into two groups: AOT (action observation combined with practicing the observed actions) and "Landscape" (same physical training combined with landscape-videos observation). At baseline and 4-week, patients underwent clinical evaluation and fMRI...
October 24, 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27776130/central-pain-processing-in-early-stage-parkinson-s-disease-a-laser-pain-fmri-study
#11
Christine Petschow, Lukas Scheef, Sebastian Paus, Nadine Zimmermann, Hans H Schild, Thomas Klockgether, Henning Boecker
BACKGROUND & OBJECTIVE: Pain is a common non-motor symptom in Parkinson's disease. As dopaminergic dysfunction is suggested to affect intrinsic nociceptive processing, this study was designed to characterize laser-induced pain processing in early-stage Parkinson's disease patients in the dopaminergic OFF state, using a multimodal experimental approach at behavioral, autonomic, imaging levels. METHODS: 13 right-handed early-stage Parkinson's disease patients without cognitive or sensory impairment were investigated OFF medication, along with 13 age-matched healthy control subjects...
2016: PloS One
https://www.readbyqxmd.com/read/27757820/increased-brain-connectivity-and-activation-after-cognitive-rehabilitation-in-parkinson-s-disease-a-randomized-controlled-trial
#12
María Díez-Cirarda, Natalia Ojeda, Javier Peña, Alberto Cabrera-Zubizarreta, Olaia Lucas-Jiménez, Juan Carlos Gómez-Esteban, Maria Ángeles Gómez-Beldarrain, Naroa Ibarretxe-Bilbao
Cognitive rehabilitation programs have demonstrated efficacy in improving cognitive functions in Parkinson's disease (PD), but little is known about cerebral changes associated with an integrative cognitive rehabilitation in PD. To assess structural and functional cerebral changes in PD patients, after attending a three-month integrative cognitive rehabilitation program (REHACOP). Forty-four PD patients were randomly divided into REHACOP group (cognitive rehabilitation) and a control group (occupational therapy)...
October 18, 2016: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/27717835/a-resting-state-fmri-study-on-early-stage-drug-na%C3%A3-ve-parkinson-s-disease-patients-with-drooling
#13
Yanbing Hou, Chunyan Luo, Jing Yang, Wei Song, Ruwei Ou, Wanglin Liu, Qiyong Gong, Huifang Shang
OBJECTIVE: Drooling is a common symptom in Parkinson's disease (PD). This study used resting-state functional MRI (fMRI) to evaluate the brain connectivity of cortico-striatal circuits in PD patients with drooling. METHOD: We enrolled 30 early-stage drug-naïve PD patients and 30 matched normal controls. Among the PD patients, 15 patients were classified as "droolers" with the presence of drooling and 15 patients as "non-droolers" with the absence of drooling. All participants underwent resting-state fMRI scans on a 3-T MR system, focusing on the functional connectivity of striatum subregions...
October 4, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27697694/regional-expression-of-the-mapt-gene-is-associated-with-loss-of-hubs-in-brain-networks-and-cognitive-impairment-in-parkinson-disease-and-progressive-supranuclear-palsy
#14
Timothy Rittman, Mikail Rubinov, Petra E Vértes, Ameera X Patel, Cedric E Ginestet, Boyd C P Ghosh, Roger A Barker, Maria Grazia Spillantini, Edward T Bullmore, James B Rowe
Abnormalities of tau protein are central to the pathogenesis of progressive supranuclear palsy, whereas haplotype variation of the tau gene MAPT influences the risk of Parkinson disease and Parkinson's disease dementia. We assessed whether regional MAPT expression might be associated with selective vulnerability of global brain networks to neurodegenerative pathology. Using task-free functional magnetic resonance imaging in progressive supranuclear palsy, Parkinson disease, and healthy subjects (n = 128), we examined functional brain networks and measured the connection strength between 471 gray matter regions...
September 9, 2016: Neurobiology of Aging
https://www.readbyqxmd.com/read/27689020/influence-of-aerobic-exercise-training-on-the-neural-correlates-of-motor-learning-in-parkinson-s-disease-individuals
#15
C Duchesne, F Gheysen, A Bore, G Albouy, A Nadeau, M E Robillard, F Bobeuf, A L Lafontaine, O Lungu, L Bherer, J Doyon
BACKGROUND: Aerobic exercise training (AET) has been shown to provide general health benefits, and to improve motor behaviours in particular, in individuals with Parkinson's disease (PD). However, the influence of AET on their motor learning capacities, as well as the change in neural substrates mediating this effect remains to be explored. OBJECTIVE: In the current study, we employed functional Magnetic Resonance Imaging (fMRI) to assess the effect of a 3-month AET program on the neural correlates of implicit motor sequence learning (MSL)...
2016: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27659747/altered-functional-connectivity-in-the-default-mode-network-is-associated-with-cognitive-impairment-and-brain-anatomical-changes-in-parkinson-s-disease
#16
Olaia Lucas-Jiménez, Natalia Ojeda, Javier Peña, María Díez-Cirarda, Alberto Cabrera-Zubizarreta, Juan Carlos Gómez-Esteban, María Ángeles Gómez-Beldarrain, Naroa Ibarretxe-Bilbao
OBJECTIVE: To assess whether functional neural connectivity is disrupted between the regions of the default mode network (DMN) in Parkinson's disease (PD) and how this connectivity is related to cognition, brain gray matter structure and white matter integrity and diffusivity. METHODS: Thirty-seven PD patients and 16 healthy controls were evaluated, using resting-state functional magnetic resonance imaging (MRI), T1-weighted MRI, diffusion-weighted imaging and a battery of cognitive tests...
September 10, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27611959/altered-resting-state-functional-connectivity-of-the-striatum-in-parkinson-s-disease-after-levodopa-administration
#17
Wanqun Yang, Bin Liu, Biao Huang, Ruiwang Huang, Lijuan Wang, Yuhu Zhang, Xiong Zhang, Kai Wu
BACKGROUND: Despite improvement in motor symptoms, the effect of dopaminergic medications on cognition in patients with Parkinson's disease (PD) is less clear. The purpose of this study was to reveal levodopa-induced acute changes in the functional connectivity of the striatum in patients with PD compared with matched untreated patients and healthy volunteers. METHODS: Twenty-two patients with PD underwent functional magnetic resonance imaging both ON and OFF dopamine-replacement therapy on two consecutive days...
2016: PloS One
https://www.readbyqxmd.com/read/27545665/distinct-functional-properties-of-the-vertical-and-horizontal-saccadic-network-in-health-and-parkinson-s-disease-an-eye-tracking-and-fmri-study
#18
J Lemos, D Pereira, L Almendra, D Rebelo, M Patrício, J Castelhano, G Cunha, C Januário, L Cunha, A Freire, M Castelo-Branco
Saccadic behaviour ranges from reflexive (e.g., prosaccade) to goal oriented voluntary movements (e.g., antisaccade). Behavioural asymmetries between vertical and horizontal saccades have been described both in normal individuals (greater delay of vertical prosaccades) and in disease states such as Parkinson's disease (PD) (prosaccades are short and antisaccades are delayed, especially in the vertical plane, possibly due to a frontostriatal deficit). Importantly, the cortical mechanisms for the generation of vertical saccades are largely unknown, both in health and disease, when compared with their horizontal counterpart...
October 1, 2016: Brain Research
https://www.readbyqxmd.com/read/27472694/altered-directional-connectivity-between-emotion-network-and-motor-network-in-parkinson-s-disease-with-depression
#19
Peipeng Liang, Gopikrishna Deshpande, Sinan Zhao, Jiangtao Liu, Xiaoping Hu, Kuncheng Li
Depression is common in patients with Parkinson's disease (PD), which can make all the other symptoms of PD much worse. It is thus urgent to differentiate depressed PD (DPD) patients from non-depressed PD (NDPD).The purpose of the present study was to characterize alterations in directional brain connectivity unique to Parkinson's disease with depression, using resting state functional magnetic resonance imaging (rs-fMRI).Sixteen DPD patients, 20 NDPD patients, 17 patients with major depressive disorder (MDD) and 21 healthy control subjects (normal controls [NC]) underwent structural MRI and rs-fMRI scanning...
July 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27462265/different-alterations-of-cerebral-regional-homogeneity-in-early-onset-and-late-onset-parkinson-s-disease
#20
Ke Sheng, Weidong Fang, Yingcheng Zhu, Guangying Shuai, Dezhi Zou, Meilan Su, Yu Han, Oumei Cheng
UNLABELLED: HIGHLIGHTS Eighteen EOPD, 21 LOPD and 37 age-matched normal control subjects participated in the resting state fMRI scans.Age at onset of PD modulates the distribution of cerebral regional homogeneity during resting state.Disproportionate putamen alterations are more prominent in PD patients with a younger age of onset. OBJECTIVE: Early-onset Parkinson's disease (EOPD) is distinct from late-onset PD (LOPD) as it relates to the clinical profile and response to medication...
2016: Frontiers in Aging Neuroscience
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