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https://www.readbyqxmd.com/read/28351128/nanoparticles-of-titanium-and-zinc-oxides-as-novel-agents-in-tumor-treatment-a-review
#1
Janusz Bogdan, Joanna Pławińska-Czarnak, Joanna Zarzyńska
Cancer has become a global problem. On all continents, a great number of people are diagnosed with this disease. In spite of the progress in medical care, cancer still ends fatal for a great number of the ill, either as a result of a late diagnosis or due to inefficiency of therapies. The majority of the tumors are resistant to drugs. Thus, the search for new, more effective therapy methods continues. Recently, nanotechnology has been attributed with big expectations in respect of the cancer fight. That interdisciplinary field of science creates nanomaterials (NMs) and nanoparticles (NPs) that can be applied, e...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28351089/leptin-and-its-receptors-in-human-placenta-of-small-adequate-and-large-for-gestational-age-newborns
#2
Maria-Luisa Lazo-de-la-Vega-Monroy, Martha I González-Domínguez, Silvio Zaina, Myrna Sabanero, Leonel Daza-Benítez, Juan Manuel Malacara, Gloria Barbosa-Sabanero
Alterations in birth weight impact postnatal outcome and adult metabolic health. Therefore, fetal growth regulation is crucial for preventing chronic metabolic diseases. Leptin has been suggested to play an important role in placental and fetal growth, albeit its specific mechanisms of action have not been elucidated. The aim of this study was to analyze leptin concentrations in placenta, cord blood, and maternal blood of SGA, AGA, and LGA (small, adequate and large for gestational age, respectively) newborns, as well as placental leptin receptor (LEPRa and LEPRb) protein expression...
March 28, 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28351086/independent-risk-factors-predicting-central-lymph-node-metastasis-in-papillary-thyroid-microcarcinoma
#3
Xiaolong Yu, Xuejia Song, Wenhai Sun, Shihua Zhao, Jiajun Zhao, Yan-Gang Wang
The incidence of papillary thyroid microcarcinoma (PTMC) has risen rapidly in recent years, and PTMC patients with central lymph node metastasis (CLNM) usually have poor prognosis. Independent risk factors predicting CLNM in PTMC have not been well understood. The aim of our study was to identify useful clinicopathological risk factors predicting CLNM in PTMC patients. This was a retrospective study of 917 patients with PTMC treated with surgery from January 2014 to December 2015 in our hospital. The relationship between clinicopathological factors and CLNM was analyzed to identify those factors predicting CLNM in PTMC...
March 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28351085/thyroid-function-and-metabolic-syndrome-a-population-based-thyroid-study
#4
Ladan Mehran, Atieh Amouzegar, Parnian Kheirkhah Rahimabad, Maryam Tohidi, Zhale Tahmasebinejad, Fereidoun Azizi
The impact of thyroid dysfunction in subclinical ranges on metabolic syndrome (MetS) is not well known. The aim of the present study is to evaluate the association of thyroid dysfunction with MetS and its components. In the cross-sectional population-based Tehran Thyroid Study, out of 5 786 randomly selected participants, aged≥20 years, subjects with thyroid nodules and cancer or any severe systemic disease, those who were pregnant and those using thyroid medication were excluded, leaving 5 422 subjects to be investigated...
March 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28351070/does-resection-of-the-posterior-longitudinal-ligament-impact-the-incidence-of-c5-palsy-after-cervical-corpectomy-procedures-a-review-of-459-consecutive-cases
#5
Ahmad Nassr, Ilyas S Aleem, Jason C Eck, Barrett Woods, Ravi K Ponnappan, William F Donaldson, James D Kang
STUDY DESIGN: Retrospective review. OBJECTIVE: To evaluate key risk factors for the development of C5 palsy after cervical corpectomy, including resection of the posterior longitudinal ligament (PLL). SUMMARY OF BACKGROUND DATA: Postoperative C5 palsy is a well-known complication after cervical spine surgery. It is unknown whether resection of the PLL affects the incidence of C5 palsy. METHODS: We performed a retrospective review of 459 consecutive patients undergoing anterior cervical corpectomies over a 15-year period...
April 1, 2017: Spine
https://www.readbyqxmd.com/read/28351069/transition-to-independence-characteristics-and-outcomes-of-mentored-career-development-kl2-scholars-at-clinical-and-translational-science-award-institutions
#6
Carol Sweeney, Lisa S Schwartz, Robert Toto, Carol Merchant, Alecia S Fair, Janice L Gabrilove
PURPOSE: To describe the transition from mentored to independent research funding for clinical and translational scholars supported by institutional KL2 Mentored Career Development programs. METHOD: In 2013, faculty leaders at Clinical and Translational Science Award institutions completed an online survey, reporting characteristics of scholars in their KL2 programs from 2006 to 2013. The primary outcome variable was a report that the scholar had received independent funding as a principal investigator...
April 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28351068/what-attitudes-and-values-are-incorporated-into-self-as-part-of-professional-identity-construction-when-becoming-a-surgeon
#7
Alexandra Cope, Jeff Bezemer, Stella Mavroveli, Roger Kneebone
PURPOSE: To make explicit the attitudes and values of a community of surgeons, with the aim of understanding professional identity construction within a specific group of residents. METHOD: Using a grounded theory method, the authors collected data from 16 postgraduate surgeons through interviews. They complemented these initial interview data with ethnographic observations and additional descriptive interviews to explore the attitudes and values learned by surgeons during residency training (2010-2013)...
April 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28351066/bringing-rounds-back-to-the-patient-a-one-year-evaluation-of-the-chiefs-service-model-for-inpatient-teaching
#8
Nadia L Bennett, Judd D Flesch, Peter Cronholm, James B Reilly, Jack Ende
PURPOSE: The Chiefs' Service (CS), a structured approach to inpatient teaching rounds, focuses on resident education and patient-centered care without disrupting patient census sizes or admitting cycles. It has five key elements: morning huddles; bedside rounds; diagnostic "time-outs"; day-of-discharge rounds; and postdischarge follow-up rounds. The authors hypothesized the CS model would be well received by residents and considered more effective than more-traditional rounds. METHOD: The CS was implemented on Penn Presbyterian Medical Center's general medicine inpatient service using a quasi-experimental design...
April 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28351053/macular-edema-rationale-for-therapy
#9
Thomas J Wolfensberger
Macular edema represents the end-stage of multiple pathophysiological pathways in a multitude of ocular vascular, inflammatory, and other diseases. The rationale for clinical treatment of macular edema is based on the understanding and the inhibition of these pathophysiological mechanisms. When macular edema is caused by a generalized health problem such as diabetes, high blood pressure, or generalized inflammatory conditions, treatment of these generalized diseases can in many cases cure macular edema directly...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28351047/postsurgical-cystoid-macular-edema
#10
Dinah Zur, Anat Loewenstein
Cystoid macular edema (CME) is a primary cause of reduced vision following both cataract and successful vitreoretinal surgery. The incidence of clinical CME following modern cataract surgery is 0.1-2.35%. Preexisting conditions such as diabetes mellitus and uveitis as well as intraoperative complications can raise the risk of postsurgical CME. The etiology of CME is not completely understood. Prolapsed or incarcerated vitreous and postoperative inflammatory processes have been proposed as causative agents. Pseudophakic CME is characterized by poor postoperative visual acuity...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28351046/retinal-vein-occlusions
#11
Jost B Jonas, Jordi Monés, Agnès Glacet-Bernard, Gabriel Coscas
Retinal vein occlusions (RVOs) have been defined as retinal vascular disorders characterized by dilatation of retinal veins with retinal and subretinal hemorrhages, macular edema, and a varying degree of retinal ischemia. Retinal angiography, either as fluorescein and indocyanine green (ICG) angiography or in the form of optical coherence tomography (OCT)-based angiography, is essential for the diagnosis and assessment of the prognosis of RVOs. It allows the differentiation of diverse types of RVOs, such as perfused or nonperfused, as well as the detection of different modalities in the natural history of RVOs...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28351042/intracellular-edema
#12
Raja Narayanan, Baruch D Kuppermann
The macula is predisposed to edema in various retinal conditions, even when the insult is remote from the macula. The various factors that may predispose the macula to edema include high metabolic activity, radial arrangement of the Henle's layer, lack of inner layers at the fovea, and lack of blood supply at the fovea. The edema is most pronounced in the outer plexiform layer (Henle's layer). Alteration in the blood-retinal barrier and ischemia cause disturbances in vascular permeability as well as with the function of Müller cells...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28351026/common-variants-of-vitamin-d-receptor-gene-polymorphisms-and-susceptibility-to-coronary-artery-disease-a-systematic-review-and-meta-analysis
#13
Shahab Alizadeh, Kurosh Djafarian, Hamzeh Alizadeh, Reza Mohseni, Sakineh Shab-Bidar
BACKGROUND AND AIMS: ApaI, FokI, TaqI, and BsmI polymorphisms in the vitamin D receptor (VDR) gene have been reported to be associated with the risk of coronary artery disease (CAD), although the results of previous studies have been inconsistent. The aim of this study was to explore whether these polymorphisms play a role in the genetic susceptibility to CAD. METHODS: A comprehensive search of Medline and Embase databases was conducted for studies evaluating the association between the VDR polymorphisms and CAD risk...
March 29, 2017: Journal of Nutrigenetics and Nutrigenomics
https://www.readbyqxmd.com/read/28351012/a-comprehensive-overview-on-electro-active-biofilms-role-of-exo-electrogens-and-their-microbial-niches-in-microbial-fuel-cells-mfcs
#14
Ganesh Dattatraya Saratale, Rijuta Ganesh Saratale, Muhammad Kashif Shahid, Guangyin Zhen, Gopalakrishnan Kumar, Han-Seung Shin, Young-Gyun Choi, Sang-Hyoun Kim
Microbial fuel cells (MFCs) are biocatalyzed systems which can drive electrical energy by directly converting chemical energy using microbial biocatalyst and are considered as one of the important propitious technologies for sustainable energy production. Much research on MFCs experiments is under way with great potential to become an alternative to produce clean energy from renewable waste. MFCs have been one of the most promising technologies for generating clean energy industry in the future. This article summarizes the important findings in electro-active biofilm formation and the role of exo-electrogens in electron transfer in MFCs...
March 25, 2017: Chemosphere
https://www.readbyqxmd.com/read/28351007/catalytic-role-of-iron-in-the-formation-of-silver-nanoparticles-in-photo-irradiated-ag-dissolved-organic-matter-solution
#15
Yongguang Yin, Dan Han, Chao Tai, Zhiqiang Tan, Xiaoxia Zhou, Sujuan Yu, Jingfu Liu, Guibin Jiang
Photo-reduction of Ag(+) to silver nanoparticle (AgNPs) by dissolved organic matter (DOM) is a possible source of naturally occurring AgNPs. However, how this photo-reduction process is influenced by ubiquitous metal ions is still not well understood. In addition, in previous studies, the formation of AgNPs in DOM solution was usually monitored by UV-Vis spectroscopy, and there is still lack of quantitative analysis for the formed AgNPs. In the present study, the role of Fe(2+)/Fe(3+) at environmental concentration level on this photochemical process was investigated, and the enhanced formation of AgNPs by Fe(2+)/Fe(3+) was probed and quantified by using UV-Vis spectroscopy, transmission electron microscopy, and liquid chromatography-inductively coupled plasma mass spectrometry...
March 25, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28350999/discovery-of-novel-1-2-3-4-tetrahydrobenzo-4-5-thieno-2-3-c-pyridine-derivatives-as-potent-and-selective-cyp17-inhibitors
#16
Mingliang Wang, Yanjia Fang, Shoulai Gu, Fangfang Chen, Zhengjiang Zhu, Xun Sun, Jidong Zhu
The inhibition of CYP17 to block androgen biosynthesis is a well validated strategy for the treatment of prostate cancer. Herein we reported the design, synthesis and structure-activity relationship (SAR) study for a series of novel 1,2,3,4- tetrahydrobenzo[4,5]thieno[2,3-c]pyridine derivatives. Some analogs demonstrated a potent inhibition to both rat and human CYP17 protein and reduced testosterone production in human H295R cell line. Some analogs also showed high selectivity against other CYP enzymes such as 3A4, 1A2, 2C9, 2C19 and 2D6, which may limit side effects due to drug-drug interactions...
March 21, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28350993/convergent-strategy-for-the-synthesis-of-s-linked-oligoxylans
#17
Beatrice Bonora, Irene Boos, Mads H Clausen
Arabinoxylans (AX) are a major class of hemicellulose and an important polysaccharide component of lignocellulosic biomass. To utilize the glycan polymer effectively, it is desirable to learn more about the enzymatic hydrolysis of AXs. Well-defined glycans can help to elucidate these processes. Here, we report the efficient synthesis of a mixed O- and S-linked tetraxylan. This thio-oligosaccharide has been developed as a putative inhibitor of arabinoxylan degrading enzymes used for the saccharification of biomass...
March 21, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/28350989/mir-219-cooperates-with-mir-338-in-myelination-and-promotes-myelin-repair-in-the-cns
#18
Haibo Wang, Ana Lis Moyano, Zhangyan Ma, Yaqi Deng, Yifeng Lin, Chuntao Zhao, Liguo Zhang, Minqing Jiang, Xuelian He, Zhixing Ma, Fanghui Lu, Mei Xin, Wenhao Zhou, Sung Ok Yoon, Ernesto R Bongarzone, Q Richard Lu
A lack of sufficient oligodendrocyte myelination contributes to remyelination failure in demyelinating disorders. miRNAs have been implicated in oligodendrogenesis; however, their functions in myelin regeneration remained elusive. Through developmentally regulated targeted mutagenesis, we demonstrate that miR-219 alleles are critical for CNS myelination and remyelination after injury. Further deletion of miR-338 exacerbates the miR-219 mutant hypomyelination phenotype. Conversely, miR-219 overexpression promotes precocious oligodendrocyte maturation and regeneration processes in transgenic mice...
March 27, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28350988/micrornas-establish-uniform-traits-during-the-architecture-of-vertebrate-embryos
#19
Dionna M Kasper, Albertomaria Moro, Emma Ristori, Anand Narayanan, Guillermina Hill-Teran, Elizabeth Fleming, Miguel Moreno-Mateos, Charles E Vejnar, Jing Zhang, Donghoon Lee, Mengting Gu, Mark Gerstein, Antonio Giraldez, Stefania Nicoli
Proper functioning of an organism requires cells and tissues to behave in uniform, well-organized ways. How this optimum of phenotypes is achieved during the development of vertebrates is unclear. Here, we carried out a multi-faceted and single-cell resolution screen of zebrafish embryonic blood vessels upon mutagenesis of single and multi-gene microRNA (miRNA) families. We found that embryos lacking particular miRNA-dependent signaling pathways develop a vascular trait similar to wild-type, but with a profound increase in phenotypic heterogeneity...
March 27, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28350976/neuroendocrine-tumor-of-the-common-bile-duct-case-report
#20
C Raspanti, N Falco, V Silvestri, G Rotolo, S Bonventre, G Gulotta
Neuroendocrine tumors (NET) are a very heterogeneous group of neoplasms; in recent years we have seen an increase in their incidence (3.65 /100.000/year). They can be associated with hereditary endocrine syndromes (MEN, Von Hippel Lindau); they can occur at any age and the incidence is slightly higher in men than women. The aetiology of the neuroendocrine tumors is unclear; in most cases, inflammation of the bile ducts may be the underlying cause and for this reason, the initial patient's evaluation should be focused on the different aspects concerning the oncological one and the possible sequelae of the biliary obstructions that can evolve in biliary sepsis...
November 2016: Il Giornale di Chirurgia
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