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https://www.readbyqxmd.com/read/29141149/surface-modification-of-cisplatin-complexed-gold-nanoparticles-and-its-influence-on-colloidal-stability-drug-loading-and-release
#1
Jiaojie Tan, Tae Joon Cho, De-Hao Tsai, Jingyu Liu, John M Pettibone, Rian You, Vincent A Hackley, Michael R Zachariah
Cisplatin-complexed gold nanoparticles (PtII-AuNP) provide a promising strategy for chemo-radiation based anticancer drugs. Effective design of such platforms necessitates reliable assessment of surface engineering on a quantitative basis, and its influence on drug payload, stability and release. In this paper, polyethylene glycol (PEG) stabilized PtII-AuNP was synthesized as a model anti-tumor drug platform, where PtII is attached via a carboxyl terminated dendron ligand. Surface modification by PEG and its influence on drug loading, colloidal stability and drug release were assessed...
November 15, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29141139/the-effect-of-synthetic-high-density-lipoproteins-modification-with-polyethylene-glycol-on-pharmacokinetics-and-pharmacodynamics
#2
Dan Li, Maria V Fawaz, Emily E Morin, Ran Ming, Denis Sviridov, Jie Tang, Rose Ackerman, Karl Olsen, Alan T Remaley, Anna Schwendeman
Synthetic high density lipoprotein nanoparticles (sHDL) capable of mobilizing excess cholesterol from atherosclerotic arteries and delivering it to the liver for elimination have been shown to reduce plaque burden in patients. Unfortunately, sHDLs have a narrow therapeutic index and relative to the endogenous HDL shorter circulation half-life. Surface modification with polyethylene glycol (PEG) was investigated for its potential to extend sHDL circulation in vivo. Various amounts (2.5, 5 and 10%) and different chain lengths (2 and 5 kDa) of PEG-modified lipids were incorporated in sHDL's lipid membrane...
November 15, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29137172/fluorescent-magnetopolymersomes-a-theranostic-platform-to-track-intracellular-delivery
#3
Oliver Bixner, Noga Gal, Christoph Zaba, Andrea Scheberl, Erik Reimhult
We present a potential theranostic delivery platform based on the amphiphilic diblock copolymer polybutadiene-block-poly (ethylene oxide) combining covalent fluorescent labeling and membrane incorporation of superparamagnetic iron oxide nanoparticles for multimodal imaging. A simple self-assembly and labeling approach to create the fluorescent and magnetic vesicles is described. Cell uptake of the densely PEGylated polymer vesicles could be altered by surface modifications that vary surface charge and accessibility of the membrane active species...
November 13, 2017: Materials
https://www.readbyqxmd.com/read/29133206/relationship-between-polarities-of-antibiotic-and-polymer-matrix-on-nanoparticle-formulations-based-on-aliphatic-polyesters
#4
J A S Ritsema, E M A Herschberg, S E Borgos, C Løvmo, R Schmid, Y M Te Welscher, G Storm, C F van Nostrum
In the field of nanomedicine, nanoparticles are developed to target antibiotics to sites of bacterial infection thus enabling adequate drug exposure and decrease development of resistant bacteria. In the present study, we investigated the encapsulation of two antibiotics with different polarity into different PEGylated polymeric nanoparticles based on aliphatic polyesters, to obtain a better understanding of critical factors determining encapsulation and release. The nanoparticles were prepared from diblock copolymers comprising of a poly(ethylene glycol) block attached to an aliphatic polyester block of varying polarity: poly(lactic-co-glycolic acid) (mPEG-PLGA), poly(lactic-co-hydroxymethyl glycolic acid) (mPEG-PLHMGA) and poly(lactic-co-benzyloxymethyl glycolic acid) (mPEG-PLBMGA)...
November 10, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29132238/nanomicelle-drug-with-acid-triggered-doxorubicin-release-and-enhanced-cellular-uptake-ability-based-on-mpeg-graft-poly-n-2-aminoethyl-l-aspartamide-hexahydrophthalic-acid-copolymers
#5
Li Cao, Yi Xiao, Wei Lu, Shiyuan Liu, Lin Gan, Jiahui Yu, Jin Huang
In order to achieve the passive tumor targeting and acid-triggered drugs release in lysosomes, optimized delivery system for doxorubicin based on pH-sensitive complex nanomicelles with suitable particle size was developed in this research. Particularly, poly(L-succinimide) was thoroughly ring-opened by ethylenediamine to give the poly(N-(2-aminoethyl)-L-aspartamide). Then, graft copolymer mPEG-graft-poly(N-(2-aminoethyl)-L-aspartamide)-hexahydrophthalic acid (mPEG-g-P(ae-Asp)-Hap) was synthesized by grafting mPEG-2000 and hexahydrophthalic anhydride onto poly(N-(2-aminoethyl)-L-aspartamide)...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/29129788/a-new-formulation-of-poly-maotib-nanoparticles-as-an-efficient-contrast-agent-for-in-vivo-x-ray-imaging
#6
Justine Wallyn, Nicolas Anton, Christophe Serra, Michel Bouquey, Mayeul Collot, Halina Anton, Jean-Luc Weickert, Nadia Messaddeq, Thierry F Vandamme
Polymeric nanoparticles (PNPs) are gaining increasing importance as nanocarriers or contrasting material for preclinical diagnosis by micro-CT scanner. Here, we investigated a straightforward approach to produce a biocompatible, radiopaque, and stable polymer-based nanoparticle contrast agent, which was evaluated on mice. To this end, we used a nanoprecipitation dropping technique to obtain PEGylated PNPs from a preformed iodinated homopolymer, poly(MAOTIB), synthesized by radical polymerization of 2-methacryloyloxyethyl(2,3,5-triiodobenzoate) monomer (MAOTIB)...
November 9, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29129079/macroscopic-assembly-of-gold-nanorods-into-superstructures-with-controllable-orientations-by-anisotropic-affinity-interaction
#7
Yun Rong, Liping Song, Peng Si, Lei Zhang, Xuefei Lu, Jiawei Zhang, Zhihong Nie, Youju Huang, Tao Chen
2D or 3D highly ordered arrays of anisotropic nanoparticles provide attracting properties that are highly desired by industry. Traditional assembly method such as evaporation usually produces the nanostructure arrays only up to milimeter scale with poor control of nanoparticle orientation, making them hardly applicable for industrial needs. Here we report a facile method to assemble centimeter-scale gold nanorod (Au NR) arrays with highly controlled nanoparticle orientation and high reproducibility. We selectively functionalized the transverse or longitudinal facets of the Au NRs with polyethylene glycol (PEG) molecules and utilized the interfacial polymeric affinity between the PEG domains on Au NRs and the PEGylated substrate to achieve the anisotropic self-assembly...
November 11, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29128664/intravenous-anti-mrsa-phosphatiosomes-mediate-enhanced-affinity-to-pulmonary-surfactants-for-effective-treatment-of-infectious-pneumonia
#8
Ching-Yun Hsu, Calvin T Sung, Ibrahim A Aljuffali, Chun-Han Chen, Kai-Yin Hu, Jia-You Fang
The aim of this study was to develop PEGylated phosphatidylcholine (PC)-rich nanovesicles (phosphatiosomes) carrying ciprofloxacin (CIPX) for lung targeting to eradicate extracellular and intracellular methicillin-resistant Staphylococcus aureus (MRSA). Soyaethyl morphonium ethosulfate (SME) was intercalated in the nanovesicle surface with the dual goals of achieving strengthened bactericidal activity of CIPX-loaded phosphatiosomes and delivery to the lungs. The isothermal titration calorimetry (ITC) results proved the strong association of SME phosphatiosomes with pulmonary surfactant...
November 8, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29128541/a-pegylated-platelet-free-plasma-hydrogel-based-composite-scaffold-enables-stable-vascularization-and-targeted-cell-delivery-for-volumetric-muscle-loss
#9
Amit Aurora, Nicole Wrice, Thomas J Walters, Robert J Christy, Shanmugasundaram Natesan
Extracellular matrix (ECM) scaffolds are being used for the clinical repair of soft tissue injuries. Although improved functional outcomes have been reported, ECM scaffolds show limited tissue specific remodeling response with concomitant deposition of fibrotic tissue. One plausible explanation is the regression of blood vessels which may be limiting the diffusion of oxygen and nutrients across the scaffold. Herein we develop a composite scaffold as a vasculo-inductive platform by integrating PEGylated platelet free plasma (PFP) hydrogel with a muscle derived ECM scaffold (m-ECM)...
November 8, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29124481/improved-antitumor-efficacy-and-pharmacokinetics-of-bufalin-via-pegylated-liposomes
#10
Jiani Yuan, Xuanxuan Zhou, Wei Cao, Linlin Bi, Yifang Zhang, Qian Yang, Siwang Wang
Bufalin was reported to show strong pharmacological effects including cardiotonic, antiviral, immune-regulation, and especially antitumor effects. The objective of this study was to determine the characterization, antitumor efficacy, and pharmacokinetics of bufalin-loaded PEGylated liposomes compared with bufalin entity, which were prepared by FDA-approved pharmaceutical excipients. Bufalin-loaded PEGylated liposomes and bufalin-loaded liposomes were prepared reproducibly with homogeneous particle size by the combination of thin film evaporation method and high-pressure homogenization method...
November 9, 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/29123382/in-vivo-study-of-doxorubicin-loaded-cell-penetrating-peptide-modified-ph-sensitive-liposomes-biocompatibility-bio-distribution-and-pharmacodynamics-in-balb-c-nude-mice-bearing-human-breast-tumors
#11
Yuan Ding, Wei Cui, Dan Sun, Gui-Ling Wang, Yu Hei, Shuai Meng, Jian-Hua Chen, Ying Xie, Zhi-Qiang Wang
In vivo evaluation of drug delivery vectors is essential for clinical translation. In BALB/c nude mice bearing human breast cancer tumors, we investigated the biocompatibility, pharmacokinetics, and pharmacodynamics of doxorubicin (DOX)-loaded novel cell-penetrating peptide (CPP)-modified pH-sensitive liposomes (CPPL) (referred to as CPPL(DOX)) with an optimal CPP density of 4%. In CPPL, a polyethylene glycol (PEG) derivative formed by conjugating PEG with stearate via acid-degradable hydrazone bond (PEG2000-Hz-stearate) was inserted into the surface of liposomes, and CPP was directly attached to liposome surfaces via coupling with stearate to simultaneously achieve long circulation time in blood and improve the selectivity and efficacy of CPP for tumor targeting...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29122661/leakage-kinetics-of-the-liposomal-chemotherapeutic-agent-doxil-the-role-of-dissolution-protonation-and-passive-transport-and-implications-for-mechanism-of-action
#12
Luisa M Russell, Margot Hultz, Peter C Searson
Doxil, a liposomal formulation of the chemotherapeutic drug doxorubicin, is FDA-approved for multiple indications. Doxil liposomes are designed to retain doxorubicin in circulation, minimize clearance by the mononuclear phagocyte system, and limit uptake in healthy tissue. Although pharmacokinetic data and survival statistics from clinical trials provide insight into distribution and efficacy, many details of the mechanism of action remain unresolved, despite the importance in translating liposome-based drug delivery systems to other molecules and cargo...
November 6, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29120820/development-of-pegylated-aspartic-acid-modified-liposome-as-a-bone-targeting-carrier-for-the-delivery-of-paclitaxel-and-treatment-of-bone-metastasis
#13
Shugo Yamashita, Hidemasa Katsumi, Nozomi Hibino, Yugo Isobe, Yumiko Yagi, Yuka Tanaka, Saki Yamada, Chihiro Naito, Akira Yamamoto
To prevent bone metastasis, we developed polyethylene glycol (PEG)-conjugated aspartic acid (Asp)-modified liposomes (PEG-Asp-Lipo) as a bone-targeting carrier of paclitaxel (PTX) by using Asp-modified 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine (DPPE-Asp). The affinity of Asp-modified liposomes to hydroxyapatite increased as the concentration of DPPE-Asp increased. The bone accumulation of [(3)H]-labeled PEG(2)-Asp(33)-Lipo was approximately 24.6% 360 min after intravenous injection in mice, in contrast to 5...
October 31, 2017: Biomaterials
https://www.readbyqxmd.com/read/29119253/higher-expression-of-inhibitory-cd158b-and-cd158e-nk-cell-receptor-and-age-predicts-treatment-response-in-children-with-chronic-hepatitis-c
#14
Anna Mania, Mariusz Kaczmarek, Paweł Kemnitz, Katarzyna Mazur-Melewska, Magdalena Figlerowicz, Jan Sikora, Wojciech Służewski, Jan Żeromski
Treatment with pegylated interferon-α and ribavirin (PEG-IFN/RBV) is the only choice for chronic hepatitis C (CHC) in children. Natural killer (NK) cells were described to play a vital role in CHC. The aim of this study was to analyze the expression of peripheral blood NK cell receptors in their relation to PEG-IFN/RBV treatment response. Study included 26 children with CHC-13 boys, age range 13.42 ± 3.28 years. Blood for biochemical, virological and cytometric testing was taken for evaluation prior to the antiviral treatment...
November 8, 2017: Medical Microbiology and Immunology
https://www.readbyqxmd.com/read/29115886/severe-pegaspargase-hypersensitivity-reaction-rates-grade-%C3%A2-3-with-intravenous-infusion-vs-intramuscular-injection-analysis-of-54-280-doses-administered-to-16-534-patients-on-children-s-oncology-group-cog-clinical-trials
#15
Michael J Burke, Meenakshi Devidas, Kelly Maloney, Anne Angiolillo, Reuven Schore, Kimberly Dunsmore, Eric Larsen, Len A Mattano, Wanda Salzer, Stuart S Winter, William Carroll, Naomi J Winick, Mignon L Loh, Elizabeth Raetz, Stephen P Hunger, Archie Bleyer
PEGylated asparaginase (pegaspargase) can be administered via intramuscular (IM) injection or intravenous (IV) infusion with a hypersensitivity reaction (HSR) incidence ranging 3-41%. We evaluated grade ≥3 HSRs when given IM vs. IV on six Children's Oncology Group (COG) leukemia trials (2003-2015) to determine differences in HSR rates. 54,280 doses were administered to 16,534 patients. Considering all doses of pegaspargase during induction, consolidation, and delayed intensification, grade ≥3 HSR rate with IM injection was 5...
November 8, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29110283/epha2-targeted-doxorubicin-nanoliposomes-for-osteosarcoma-treatment
#16
Fateme Haghiralsadat, Ghasem Amoabediny, Samira Naderinezhad, Kamran Nazmi, Jantine Posthuma De Boer, Behrouz Zandieh-Doulabi, Tymour Forouzanfar, Marco N Helder
PURPOSE: To employ Doxorubicin-loaded liposomes, modified with YSA-peptide to target EphA2, to reduce adverse effects against primary bone cells and maximize toxicity against Saos-2 osteosarcoma cells. METHODS: PEGylated liposomes were prepared by thin film method using Dipalmitoylphosphatidylcholine (DPPC), cholesterol and distearylphosphatidylethanolamine-polyethyleneglycol conjugate (DSPE-mPEG) in 67.9:29.1:3 M ratios, and loaded with DOX (L-DOX) by pH-gradient method...
November 6, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/29109796/investigating-the-effect-of-chemical-structure-of-semiconducting-polymer-nanoparticle-on-photothermal-therapy-and-photoacoustic-imaging
#17
Dongdong Li, Guobing Zhang, Weiguo Xu, Junxia Wang, Yucai Wang, Longzhen Qiu, Jianxun Ding, Xianzhu Yang
The donor-acceptor semiconducting polymers (SPs) have robust absorbance in near-infrared (NIR) region, great photostability, high photothermal conversion efficiency, and good biocompatibility. Thus, the SPs exhibit great potentials for photothermal therapy (PTT) and photoacoustic imaging (PAI). However, poor understanding of the underlying mechanisms and the correlation between the SP polymer chemical structures and their performances of PTT and PAI have significantly hindered their biomedical application. Herein, a series of acceptor-π-acceptor type (A1-π-A2) type SPs were synthesized...
2017: Theranostics
https://www.readbyqxmd.com/read/29109774/dual-functioned-pegylated-phospholipid-micelles-containing-cationic-antimicrobial-decapeptide-for-treating-sepsis
#18
Wonhwa Lee, Eun Ji Park, Gahee Min, Joonhyeok Choi, Dong Hee Na, Jong-Sup Bae
Despite intensive investigation of molecular mechanisms underlying the pathogenesis of sepsis, many aspects of sepsis remain unresolved; this hampers the development of appropriate therapeutics. In the present study, we developed a biologic nanomedicine containing a cationic antimicrobial decapeptide KSLW (KKVVFWVKFK), self-associated with biocompatible and biodegradable PEGylated phospholipid micelles (PLM), and analyzed its efficacy for treating sepsis. KSLW was modified with polyethylene glycol (PEG)-aldehyde or was conjugated with distearoylphosphatidylethanolamine (DSPE) -PEG-aldehyde...
2017: Theranostics
https://www.readbyqxmd.com/read/29108384/efficacy-safety-and-proper-dose-analysis-of-pegylated-granulocyte-colony-stimulating-factor-as-support-for-dose-dense-adjuvant-chemotherapy-in-node-positive-chinese-breast-cancer-patients
#19
Fan Zhang, RuiXia LingHu, XingYang Zhan, Ruisheng Li, Fan Feng, Xudong Gao, Lei Zhao, Junlan Yang
For high-risk breast cancer patients with positive axillary lymph nodes, dose-dense every-two-week epirubicin/cyclophosphamide-paclitaxel (ddEC-P) regimen is the optimal postoperative adjuvant therapy. However, this regimen is limited by the grade 3/4 neutropenia and febrile neutropenia (FN). There is an urgent need to explore the efficacy, safety and proper dosage of PEGylated granulocyte colony-stimulating factor (PEG-G-CSF) as support for ddEC-P in Chinese breast cancer patients with positive axillary lymph nodes...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29108206/-association-between-il28b-gene-polymorphisms-and-therapeutic-effect-of-individualized-pegylated-interferon-alpha-therapy-in-hbeag-positive-chronic-hepatitis-b-patients
#20
L J Huang, J E Yang, Z X Xu, G L Wang
No abstract text is available yet for this article.
October 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
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