Florence Rousseau, Benoit Guillet, Thibault Mura, Alexandra Fournel, Fabienne Volot, Hervé Chambost, Pierre Suchon, Brigit Frotscher, Christine Biron-Andréani, Raphaël Marlu, Nathalie Hezard, Ségolène Clayssens, Elodie Boissier, Florence Blanc-Jouvan, Pierre Chamouni, Nathalie Tieulie, Lucia Rugeri, Annie Borel-Derlon, Emmanuelle de Raucourt, Isabelle Martin-Toutain, Sabine Castet, Aurélien Lebreton, Stéphane Girault, Dominique Helley-Russick, Roseline D'Oiron, Jean-François Schved, Muriel Giansily-Blaizot
BACKGROUND: Despite the wide use of bleeding scores and the reliability of clotting factor level measurement, bleeding risk stratification before surgery remains challenging in patients with rare inherited bleeding disorders. OBJECTIVES: This multicenter observational prospective study assessed in patients with rare coagulation factor deficiency, the perioperative hemostatic management choices by hemostasis experts and the bleeding outcomes after surgery. METHODS: One hundred seventy-eight patients with low coagulation activity level (factor [F] II, FV, combined FV-FVIII, FVII, FX, or FXI <50%) underwent 207 surgical procedures...
October 2023: Research and Practice in Thrombosis and Haemostasis