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Non infectious leucocytosis

Dorothea Evers, Johanna G van der Bom, Janneke Tijmensen, Rutger A Middelburg, Masja de Haas, Saurabh Zalpuri, Karen M K de Vooght, Daan van de Kerkhof, Otto Visser, Nathalie C V Péquériaux, Francisca Hudig, Jaap Jan Zwaginga
Red cell alloantigen exposure can cause alloantibody-associated morbidity. Murine models have suggested that inflammation modulates red cell alloimmunisation. This study quantifies alloimmunisation risks during infectious episodes in humans. We performed a multicentre case-control study within a source population of patients receiving their first and subsequent red cell transfusions during an 8-year follow-up period. Patients developing a first transfusion-induced red cell alloantibody (N = 505) were each compared with two similarly exposed, but non-alloimmunised controls (N = 1010) during a 5-week 'alloimmunisation risk period' using multivariate logistic regression analysis...
December 2016: British Journal of Haematology
Ahmed N F Neamat-Allah
AIM: Lumpy skin disease (LSD) is an infectious viral disease of cattle caused by LSD virus (LSDV) of the family Poxviridae characterized by skin nodules covering all parts of the body. There are many aspects of LSD remaining unknown, thus immunological, hematological, and biochemical parameters were estimated. MATERIALS AND METHODS: During an outbreak of LSD in Sharkia governorate from Egypt, 211 cows aging (2-4 years) were examined clinically for the presence of LSD lesions during the period from July to November 2014...
September 2015: Veterinary World
E Pachkoria, E Vashakidze, T Megrelishvili, L Tevzadze
The aim of the research: identification of etiological structure of acute diarrheas and hemorrhagic colitis in Georgia, manifestation of clinical peculiarities and predictors of hemorrhagic colitis complicated by HUS ( Hemolytic-Uremic syndrome). In 2011-2013 we studied 274 hospitalized patients at the Center of Infectious Diseases, AIDS and Clinical Immunology (160 hemorrhagic colitis and 114 non-bloody diarrhea). Causative agents of hemorrhagic colitis (160 patients) were determined in 110 (69%) cases; etiology of the non-bloody diarrhea (114 patients) was established in 46 (40%) cases...
September 2014: Georgian Medical News
(no author information available yet)
Despite considerable success in study of Bordetella pertussis virulence factors, pathogenesis of whooping cough, duration of B. pertussis bacteria persistence, types and mechanisms of immune response are still keep underinvestigated. It can be explained by the absence ofadequate experimental animal model for pertussis study. Our study estimates clinical and laboratory parameters of whooping cough in non-human primates of the Old World in the process of intranasan infection by virulent B. pertussis bacteria...
2013: Vestnik Rossiĭskoĭ Akademii Meditsinskikh Nauk
Anna Bilska, Ewelina Wilińska, Monika Szturmowicz, Liliana Wawrzyńska, Anna Fijałkowska, Karina Oniszh, Andrzej Swiatowiec, Agnieszka Wsół, Adam Torbicki
Pericardial effusion is caused by various pathological agents. In differential diagnosis infectious as well as non-infectious factors have to be considered. Adult-onset Still disease (AOSD)--relatively uncommon systemic inflammatory disorder of unknown etiology--is among possible diagnosis. The disease typically affects patients in the age between 16-35 years and is characterized by spiking fever, arthralgia, evanescent salmon rash with other abnormalities including pharingitis, serositis (especially pleuritis and pericarditis) and leucocytosis as well as increased serum levels of inflammatory indicators...
2011: Pneumonologia i Alergologia Polska
Y X Liew, M P Chlebicki, W Lee, L Y Hsu, A L Kwa
Clinicians have used procalcitonin (PCT) (biomarker to differentiate bacterial from non-bacterial sepsis) to guide use of antibiotics in patients. As the data for utility of PCT to discontinue antibiotics in an antimicrobial stewardship program (ASP) are lacking, we aim to describe the outcomes of patients in whom PCT was used to discontinue antibiotics under our ASP. An antimicrobial stewardship (AS) team intervened to discontinue antibiotics in patients with persistent fever or leucocytosis, source of sepsis unknown or negative bacteriological cultures, who had completed an adequate course of antibiotic therapy and had a PCT of <0...
July 2011: European Journal of Clinical Microbiology & Infectious Diseases
Anne M E Roeters, Mathilde E Boon, Maarten van Haaften, F Vernooij, Tj Romke Bontekoe, A Peter M Heintz
The Dutch cytological coding system, KOPAC, enables to code for eight inflammatory events, that is koilocytosis (related to human papillomavirus (HPV)), Trichomonas, dysbacteriosis [related to bacterial vaginosis (BV)], Candida, Gardnerella, Actinomyces, Chlamydia, and non-specific inflammation (leucocytosis). This study presents an analysis of 1,008,879 smears. Of each smear, the age of the woman and the reason for smear taking (screening or indication) was available. The cytoscores (per mille) for these codes were calculated...
February 2010: Diagnostic Cytopathology
D Vandijck, J M Decruyenaere, S I Blot
Sepsis is a major disease entity with important clinical and economic implications. Sepsis is the hosts' reaction to infection and is characterized by a systemic inflammatory response. Because of difficulties in defining sepsis, the SIRS was introduced trying to summarize the inflammatory response in a limited set of elementary characteristics (fever or hypothermia, leucocytosis or leucopenia, tachycardia, hyperventilation). In daily practice it is essential to identify septic patients as soon as possible because early recognition results in better survival rates...
September 2006: Acta Clinica Belgica
M F Wahab, I M El-Gindy, G M Fathy
During a two years period, 16 cases having cervical lymphadenopathy presenting as prolonged fever were studied in Abbassia fever hospital, Cairo, Egypt. Patients were subjected to careful history, thorough clinical examination, complete blood picture, tuberculin test, chest x-ray, Monospot test, indirect fluorescent antibody test for toxoplasmosis, detection of cytomegalovirus antibodies and lymph node biopsy with histopathological examination. Ten within normal subjects were taken as controls. The patients were grouped on histopathological basis into 5 groups: (1) One (6%) of the cases was non-specific lymphadenitis diagnosed by clinical examination of the scalp and leucocytosis with polymorphonuclear predominance...
1998: Journal of the Egyptian Public Health Association
Juan José Olivares-Becerra, Francisco Cuan-Orozco, Joel Michel-Dueñas, María Karina Lizbeth López-Ramírez, Gabriela Abigail Velázquez-Ramírez, Alejandro González-Ojeda
INTRODUCTION: Spleen abscesses are considered as an infrequent infectious disease. An increase in its presentation has been seen due to certain pathologies or clinical conditions associated with immune suppression, endocarditis being one of the most frequent causes. Gram-positive aerobes are the main causal agents with non-specific clinical manifestations. CT scan and ultrasound are the elective choices for diagnosis and imaging support for punction and drainage. OBJECTIVE: To describe the case of a patients with splenic abscess and its possible association with massive bee bite...
September 2005: Cirugia y Cirujanos
N Gómez Rodríguez, Y Penelas-Cortés Bellas, J Ibáñez Ruán, M González Pérez, M L Sánchez Lorenzo
OBJECTIVE: To study the clinical-epidemiological characteristics of infectious spondylodiscitis (IS) in adults of our health area in the late 20 years. MATERIAL AND METHODS: We performed a retrospective analysis of the medical records of adult patients with a diagnosis of both, tuberculous (TS) and non tuberculous spondylodiscitis (NTS), between January 1983 and December 2003. The diagnosis was made when compatible clinical-radiological picture were present in association with at least two positive blood cultures and/or micro-organism recovery from vertebral samples...
November 2004: Anales de Medicina Interna: Organo Oficial de la Sociedad Española de Medicina Interna
Zheng-Yin Liu, Rui-Yuan Sheng, Xu-Li Li, Tai-Sheng Li, Ai-Xia Wang
OBJECTIVE: To investigate the manifestation, diagnosis, antifungal therapy and outcome of nosocomial fungal infections. METHODS: The clinical data of 149 patients with nosocomial fungal infections admitted in the PUMC hospital from Dec. 1981 to Nov. 2001, 67 males and 82 females with an average age of 52.32 years, including the manifestation, diagnosis, treatment and outcome, were reviewed retrospectively. RESULTS: 134 out of the 149 patients suffered from deep mycoses...
March 10, 2003: Zhonghua Yi Xue za Zhi [Chinese medical journal]
S K Acharya, S K Panda, A Saxena, S D Gupta
Acute hepatic failure (AHF) in India almost always presents with encephalopathy within 4 weeks of the onset of acute hepatitis. Further subclassification of AHF into hyperacute, acute and subacute forms may not be necessary in this geographical area, where the rapidity of onset of encephalopathy does not seem to influence survival. Viral hepatitis is the cause in approximately 95-100% of patients, who therefore constitute a more homogeneous population than AHF patients in the West. In India, hepatitis E (HEV) and hepatitis B (HBV) viruses are the most important causes of AHF; approximately 60% of cases are caused by to these viruses...
May 2000: Journal of Gastroenterology and Hepatology
B McCarron
Over a 3-year-period, 132 patients were admitted to the Infectious Diseases Unit, Ruchill Hospital, Glasgow, with non-typhoidal salmonellae enterocolitis. Salmonella enteritidis and typhimurium were isolated from 67% of admissions. Of all patients, 11% had recently travelled overseas, 12% were hypochlorhydric and 3.8% were bacteraemic. Salmonella typhimurium infection was associated with a younger age group, a more pronounced leucocytosis and an earlier and less marked summer peak than S. enteritidis.
September 1998: Journal of Infection
M P Stokkel, R P Takes, B L van Eck-Smit, R J Baatenburg de Jong
Malignant external otitis (MEO) is a severe infectious disorder usually caused by Pseudomonas aeruginosa, which most frequently affects diabetic patients. Due to its rarity, the diagnosis of MEO is often not made promptly. Extension into deeper structures or chronic osteomyelitis may occur without signs of infection on local clinical examination. Of the imaging techniques, magnetic resonance imaging provides a fairly adequate picture of the spread of the disease, but, as with computed tomography (CT) scanning and bone scintigraphy, the images remain unchanged for a long time after disease regression...
November 1997: European Journal of Nuclear Medicine
M F Abdel Wahab, T A Younis, I A Fahmy, I M el Gindy
Over two successive years, out of 187 cases of fevers of undetermined origin (FUO) admitted to Abbassia and Embaba Fever Hospitals, 30 (16%) cases proved to be of parasitic origin. Ten within normal subjects were taken as controls. Complete blood picture, repeated stool examination, rectal snip by transparency technique, ELISA for specific IgM antibodies for S. mansoni, indirect haemagglutination test for S. mansoni, Fasciola, hydatid, amoebic liver abscess and toxoplasmosis, indirect fluorescent antibody test for toxoplasmosis and abdominal ultrasonography were performed whenever indicated...
August 1996: Journal of the Egyptian Society of Parasitology
Y Floman, C Milgrom, J M Gomori, S Kenan, Y Ezra, M Liebergall
We report four patients with unilateral postpartum sacroiliitis presenting with agonising unilateral pain, an elevated ESR, elevated alkaline phosphatase levels, leucocytosis and positive bone scans. The diagnosis of a non-infectious inflammatory cause was supported by the postpartum onset, the response to non-steroidal anti-inflammatory drugs, negative aspiration cultures in two cases and the lack of changes in the sacroiliac joints on long-term follow-up radiographs.
November 1994: Journal of Bone and Joint Surgery. British Volume
J C Fenwick, M Cameron, S C Naiman, L P Haley, J J Ronco, B R Wiggs, M G Tweeddale
The diagnosis of infection in the intensive care unit is confounded by the presence of non-infectious causes of leucocytosis. Unless such causes are recognised, time and effort will be spent on unnecessary investigations and treatments. In a prospective study we have shown that the transfusion of blood frequently (45/50 patients) causes an acute leucocytosis in such patients. This effect was not seen in 8 patients who received plasma. Blood transfusion should be added to the list of non-infectious causes of leucocytosis in the critically ill...
September 24, 1994: Lancet
M H Valkenburg, G G Essed, H V Potters
Between April 1, 1985, and April 1, 1986, four cases of perinatal listeriosis were reported at the Maastricht Academic Hospital. All cases were of the early-onset type. All mothers were admitted for pre-term labour between 28 and 33 weeks of gestation. Pre-natal symptoms included maternal fever, non-characteristic influenza-like manifestations, leucocytosis and (pre-term) meconium-stained amniotic fluid. Two neonates died, one in utero and one due to listeriosis sepsis. Another neonate developed a hydrocephalus...
April 1988: European Journal of Obstetrics, Gynecology, and Reproductive Biology
M Sato, Y Saito, S Fujimura, K Usuda, S Takahashi, K Kanma, S Imai, H Suda, T Nakada, K Hashimoto
Postoperative bronchopleural fistulas, although reduced in incidence, remain as a grave complication of pulmonary resection. In our department, cases of lung cancer have been rapidly increasing and those of infectious diseases have been decreasing. In light of this trend, the causes of bronchopleural fistulas may have changed, and thus we studied recent cases of postoperative bronchopleural fistulas from 1982 to 1986. Bronchopleural fistulas were seen in 5 (7.8%) of 64 cases of inflammatory diseases and in 19 (4%) of 481 cases of lung cancer...
March 1989: [Zasshi] [Journal]
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