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https://www.readbyqxmd.com/read/29624206/paracetamol-acetaminophen-for-patent-ductus-arteriosus-in-preterm-or-low-birth-weight-infants
#1
REVIEW
Arne Ohlsson, Prakeshkumar S Shah
BACKGROUND: In preterm newborns, the ductus arteriosus frequently fails to close and the infants require medical or surgical closure of the patent ductus arteriosus (PDA). A PDA can be treated surgically; or medically with one of two prostaglandin inhibitors, indomethacin or ibuprofen. Case reports suggest that paracetamol may be an alternative for the closure of a PDA. An association between prenatal or postnatal exposure to paracetamol and later development of autism or autism spectrum disorder has been reported...
April 6, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29615027/comparative-efficacy-of-chinese-herbal-injections-for-treating-acute-cerebral-infarction-a-network-meta-analysis-of-randomized-controlled-trials
#2
Shi Liu, Jia-Rui Wu, Dan Zhang, Kai-Huan Wang, Bing Zhang, Xiao-Meng Zhang, Di Tan, Xiao-Jiao Duan, Ying-Ying Cui, Xin-Kui Liu
BACKGROUND: Chinese herbal injections (CHIs) are prepared by extracting and purifying effective substances from herbs (or decoction pieces) using modern scientific techniques and methods. CHIs combined with aspirin + anticoagulants + dehydrant + neuroprotectant (AADN) are believed to be effective for the treatment of acute cerebral infarction (ACI). However, no randomized controlled trial (RCT) has been performed to directly compare the efficacies of different regimens of CHIs. Therefore, we performed a systematic review and network meta-analysis (NMA) to compare the efficacies of different regimens of CHIs for ACI...
April 3, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29595628/what-is-the-superior-surgical-strategy-for-bi-level-cervical-spondylosis-anterior-cervical-disc-replacement-or-anterior-cervical-decompression-and-fusion-a-meta-analysis-from-11-studies
#3
He Zhao, Li-Jun Duan, Yu-Shan Gao, Yong-Dong Yang, Xiang-Sheng Tang, Ding-Yan Zhao, Yang Xiong, Zhen-Guo Hu, Chuan-Hong Li, Xing Yu
BACKGROUND: Nowadays, anterior cervical artificial disc replacement (ACDR) has achieved favorable outcomes in treatment for patients with single-level cervical spondylosis. However, It is still controversial that whether or not it will become a potent therapeutic alternation in treating 2 contiguous levels cervical spondylosis compared with anterior cervical decompression and fusion (ACDF). Therefore, we conducted a systematic review and meta-analysis to compare the efficacy and safety of ACDR and ACDF in patients with 2 contiguous levels cervical spondylosis...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29595449/routine-low-dose-continuous-or-nocturnal-oxygen-for-people-with-acute-stroke-three-arm-stroke-oxygen-supplementation-rct
#4
Christine Roffe, Tracy Nevatte, Jon Bishop, Julius Sim, Cristina Penaloza, Susan Jowett, Natalie Ives, Richard Gray, Phillip Ferdinand, Girish Muddegowda
BACKGROUND: Stroke is a major cause of death and disability worldwide. Hypoxia is common after stroke and is associated with worse outcomes. Oxygen supplementation could prevent hypoxia and secondary brain damage. OBJECTIVES: (1) To assess whether or not routine low-dose oxygen supplementation in patients with acute stroke improves outcome compared with no oxygen; and (2) to assess whether or not oxygen given at night only, when oxygen saturation is most likely to be low, is more effective than continuous supplementation...
March 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29428293/impact-of-spine-alignment-on-the-rotator-cuff-in-long-term-wheelchair-users
#5
Yasser Kentar, Manuela Brunner, Thomas Bruckner, Andreas Hug, Patric Raiss, Felix Zeifang, Markus Loew, Haidara Almansour, Michael Akbar
BACKGROUND: We investigated the impact of poor seated posture on the prevalence of rotator cuff tears (RCTs) among wheelchair-dependent individuals with long-standing paraplegia. METHODS: The study included 319 patients. Lateral radiographs of the spine were collected from a database and analyzed to assess the global spinopelvic alignment (SPA). Magnetic resonance images of both shoulders were obtained to detect the presence of cuff tears. Patients were divided into 2 groups: Group RCT-I included all patients with cuff tears (right, left, or bilateral), whereas group RCT-II consisted exclusively of patients with bilateral cuff tears...
February 8, 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29427112/planning-future-clinical-trials-for-machado-joseph-disease
#6
Jonas Alex Morales Saute, Laura Bannach Jardim
Spinocerebellar ataxia type 3/Machado-Joseph disease (SCA3/MJD) is an autosomal dominant multiple neurological systems degenerative disorder caused by a CAG repeat expansion at ATXN3 gene. Only a few treatments were evaluated in randomized clinical trials (RCT) in SCA3/MJD patients, with a lack of evidence for both disease-modifying and symptomatic therapies. The present chapter discuss in detail major methodological issues for planning future RCT for SCA3/MJD. There are several potential therapies for SCA3/MJD with encouraging preclinical results...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29368325/-effectiveness-of-virtual-immersion-programmes-in-patients-with-parkinson-s-disease-a-systematic-review
#7
S Morales-Gomez, I Elizagaray-Garcia, O Yepes-Rojas, L de la Puente-Ranea, A Gil-Martinez
INTRODUCTION: Parkinson disease (PD) is the second most common neurodegenerative disease. Virtual reality (VR) is being used in rehabilitation of neurological patients. To analyze the VR systems' therapeutically effectiveness through PD diagnosed subjects with variables of motor, quality of life and cognition. PATIENTS AND METHODS: Electronics database were used to look for articles: Medline, EMBASE, PEDro, CINAHL and Cochrane. The inclusion criteria were: randomized control trial (RCT) performed in PD with at least one VR variable included in the therapeutically treatment and diagnosed PD subjects...
February 1, 2018: Revista de Neurologia
https://www.readbyqxmd.com/read/29358002/the-effect-of-a-natural-food-based-tube-feeding-in-minimizing-diarrhea-in-critically-ill-neurological-patients
#8
Simone B Schmidt, Willibald Kulig, Ralph Winter, Antje S Vasold, Anette E Knoll, Jens D Rollnik
BACKGROUND & AIMS: Diarrhea has negative consequences for patients, health care staff and health care costs when neurological patients are fed enterally over long periods. We examined the effect of tube feeding with natural foods in reducing the number of fluid stool evacuations and diarrhea in critically ill neurological patients. METHODS: A multicenter, prospective, open-label and randomized controlled trial (RCT) was conducted at facilities in Germany specializing in early rehabilitation after neurological damage...
January 9, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29338147/effect-of-therapeutic-hypothermia-on-survival-and-neurological-outcome-in-adults-suffering-cardiac-arrest-a-systematic-review-and-meta-analysis
#9
Sameh M Hakim, Mona A Ammar, Mohammad S Reyad
INTRODUCTION: The aim of this review is to determine current evidence for the effect of therapeutic hypothermia (TH) on survival and neurological outcome in adults suffering cardiac arrest (CA). EVIDENCE AQUISITION: We searched the Cochrane Controlled Trials Register, MEDLINE, EMBASE and NLM databases from 2000 to 2017 using the following terms: hypothermia, cooling, therapeutic, cardiac arrest, resuscitation, cardiopulmonary, CPR. Studies were eligible if they compared TH versus normothermic management in adult humans sustaining CA...
January 16, 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29333935/association-between-human-papilloma-virus-hpv-vaccination-and-risk-of-multiple-sclerosis-a-systematic-review
#10
Angela Meggiolaro, Giuseppe Migliara, Giuseppe La Torre
INTRODUCTION: The vaccination against Humanpapilloma Virus (HPV) is an effective strategy to prevent high-risk HPV infection and subsequent cervical carcinogenesis. Although the safety profile has been ascertained, the relation with the development of central nervous system (CNS) autoimmune disorders (AD) appears still controversial. Multiple Sclerosis (MS) is the most common cause of chronic neurological impairment in young people, typically striking females. The main purpose of this review was to assess the association between HPV vaccination and MS...
January 15, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29239015/treating-hepatic-encephalopathy-in-cirrhotic-patients-admitted-to-icu-with-sodium-phenylbutyrate-a-preliminary-study
#11
Nicolas Weiss, Simona Tripon, Marion Lodey, Elsa Guiller, Helga Junot, Denis Monneret, Julien Mayaux, Hélène Brisson, Maxime Mallet, Marika Rudler, Françoise Imbert-Bismut, Dominique Thabut
Hepatic encephalopathy (HE) influences short-term and long-term prognoses. Recently, glycerol phenylbutyrate (PB), that lowers ammonia by providing an alternate pathway to urea for waste nitrogen excretion, has shown that it was effective in preventing the occurrence of HE in RCT. The aim was to assess the benefits of sodium PB in cirrhotic patients admitted to ICU for overt HE, in terms of ammonia levels decrease, neurological improvement, and survival. Cirrhotic patients who presented with overt HE, ammonia levels >100 μmol/L, and did not display any contra-indication were included...
December 14, 2017: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/29200424/arm-rehabilitation-in-post-stroke-subjects-a-randomized-controlled-trial-on-the-efficacy-of-myoelectrically-driven-fes-applied-in-a-task-oriented-approach
#12
RANDOMIZED CONTROLLED TRIAL
Johanna Jonsdottir, Rune Thorsen, Irene Aprile, Silvia Galeri, Giovanna Spannocchi, Ettore Beghi, Elisa Bianchi, Angelo Montesano, Maurizio Ferrarin
PURPOSE: Motor recovery of persons after stroke may be enhanced by a novel approach where residual muscle activity is facilitated by patient-controlled electrical muscle activation. Myoelectric activity from hemiparetic muscles is then used for continuous control of functional electrical stimulation (MeCFES) of same or synergic muscles to promote restoration of movements during task-oriented therapy (TOT). Use of MeCFES during TOT may help to obtain a larger functional and neurological recovery than otherwise possible...
2017: PloS One
https://www.readbyqxmd.com/read/29188363/meta-analysis-of-adjunctive-dexamethasone-to-improve-clinical-outcome-of-bacterial-meningitis-in-children
#13
REVIEW
Ying Wang, Xinjie Liu, Yuzhen Wang, Qi Liu, Cuicui Kong, Guixia Xu
BACKGROUND: The current recommended therapies for bacterial meningitis are effective antimicrobial agents and the implementation of childhood vaccination programs. However, the role of adjunctive dexamethasone therapy in bacterial meningitis remains controversial. METHODS: Using meta-analysis, this study aims to investigate the efficacy of adjunctive dexamethasone therapy in bacterial meningitis by comparing it with antibiotic therapy. Documents of randomized controlled trials (RCT) related to the treatment of bacterial meningitis in children with dexamethasone published since the establishment of the databases to December in 2016 were retrieved from the databases of Cochrane Library, Pubmed, MEDLINE, EMBASE, Chinese BioMedical Literature Database, and China National Knowledge Infrastructure...
February 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29128525/respiratory-rehabilitation-in-multiple-sclerosis-a-narrative-review-of-rehabilitation-techniques
#14
REVIEW
J Levy, H Prigent, D Bensmail
BACKGROUND: Respiratory disorders in multiple sclerosis (MS) are an important issue. They can occur early during the course of the disease, are associated with the neurological impairment, and can lead to pneumonia and respiratory failure, which are the main causes of death in advanced MS. Prevailing impaired expiratory muscles and cough abilities has been demonstrated in this population and might constitute a specific target for rehabilitation interventions. However, international guidelines lack recommendations regarding respiratory rehabilitation in MS...
January 2018: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29075023/no-clinical-quantifiable-benefits-between-non-surgical-and-surgical-endodontic-treatment
#15
Debra M Ferrailo, Analia Veitz-Keenan
Data sourcesThe authors searched the following electronic databases: the Cochrane Oral Health Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL), Medline Ovid and Embase Ovid. The US National Registry of Clinical Trials (ClinicalTrials.gov) and the World Health Organisation (WHO) International Clinical Trials Registry Platform were searched for ongoing trials. There were no restrictions regarding language and publication date. The authors hand-searched the reference lists of the studies retrieved and key journals in the field of endodontics...
October 27, 2017: Evidence-based Dentistry
https://www.readbyqxmd.com/read/29071409/prospective-randomized-controlled-comparison-of-posterior-vs-posterior-anterior-stabilization-of-thoracolumbar-incomplete-cranial-burst-fractures-in-neurological-intact-patients-the-rasputhine-pilot-study
#16
Matti Scholz, F Kandziora, T Tschauder, M Kremer, A Pingel
PURPOSE: If surgery for thoracolumbar incomplete cranial burst fractures (Magerl A3.1.1) is necessary, the ideal stabilization strategy still remains undetermined. To justify posterior-anterior stabilization, which generates higher costs and potentially higher morbidity vs. posterior-only stabilization, clinical trials with sufficient power and adequate methodology are required. This prospective randomized single-centre pilot trial was designed to enable sufficient sample-size calculation for a randomized multicentre clinical trial (RASPUTHINE)...
October 25, 2017: European Spine Journal
https://www.readbyqxmd.com/read/29054690/removable-rigid-dressings-for-postoperative-management-of-transtibial-amputations-a-review-of-published-evidence
#17
REVIEW
James P Reichmann, Phillip M Stevens, John Rheinstein, Christopher D Kreulen
Forty years of clinical experience and peer-reviewed research studies support the use of nonweight-bearing removable rigid dressings (RRDs) as an effective means of postoperative management of transtibial amputations. We reviewed the published medical evidence regarding the use of RRDs as a postoperative management strategy, culminating in an evidence-based practice recommendation. Published peer-reviewed literature on the topic was searched and classified by level of evidence based on the research design using the scale recommended by the PM&R (level I through V)...
October 18, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28988962/prehospital-cooling-to-improve-successful-targeted-temperature-management-after-cardiac-arrest-a-randomized-controlled-trial
#18
D C Scales, S Cheskes, P R Verbeek, R Pinto, D Austin, S C Brooks, K N Dainty, K Goncharenko, M Mamdani, K E Thorpe, L J Morrison
RATIONALE: Targeted temperature management (TTM) improves survival with good neurological outcome after out-of-hospital cardiac arrest (OHCA), but is delivered inconsistently and often with delay. OBJECTIVE: To determine if prehospital cooling by paramedics leads to higher rates of 'successful TTM', defined as achieving a target temperature of 32-34°C within 6h of hospital arrival. METHODS: Pragmatic RCT comparing prehospital cooling (surface ice packs, cold saline infusion, wristband reminders) initiated 5min after return of spontaneous circulation (ROSC) versus usual resuscitation and transport...
December 2017: Resuscitation
https://www.readbyqxmd.com/read/28960283/a-randomized-prospective-pilot-trial-of-web-delivered-epilepsy-stigma-reduction-communications-in-young-adults
#19
RANDOMIZED CONTROLLED TRIAL
Martha Sajatovic, Lynn K Herrmann, Jamie R Van Doren, Curtis Tatsuoka, Elisabeth Welter, Adam T Perzynski, Ashley Bukach, Kelley Needham, Hongyan Liu, Anne T Berg
OBJECTIVE: Epilepsy is a common neurological condition that is often associated with stigmatizing attitudes and negative stereotypes among the general public. This randomized controlled trial (RCT) tested two new communication approaches targeting epilepsy stigma versus an education-alone approach. METHODS: Two brief stigma-reduction videos were developed, informed by community stakeholder input; one highlighted role competency in people with epilepsy; the other highlighted social inclusion of people with epilepsy...
November 2017: Epilepsia
https://www.readbyqxmd.com/read/28672273/does-a-parent-administrated-early-motor-intervention-influence-general-movements-and-movement-character-at-3months-of-age-in-infants-born-preterm
#20
Toril Fjørtoft, Tordis Ustad, Turid Follestad, Per Ivar Kaaresen, Gunn Kristin Øberg
BACKGROUND: Studies of preterm and term-born infants have shown absent fidgety movements and an abnormal movement character to be related to brain lesions and unfavourable neurological outcomes. AIMS: The present study examines what effect a parent-administered early intervention program applied to preterm infants in a randomised control trial (RCT) between 34 and 36weeks gestational age has on their fidgety movements and overall movement character at three months of age...
September 2017: Early Human Development
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