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Catherine Spong

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https://www.readbyqxmd.com/read/28338419/competitive-protein-binding-influences-heparin-based-modulation-of-spatial-growth-factor-delivery-for-bone-regeneration
#1
Marian H Hettiaratchi, Catherine Chou, Nicholas Servies, Johanna M Smeekens, Albert Cheng, Camden Esancy, Ronghu Wu, Todd C McDevitt, Robert E Guldberg, Laxminarayanan Krishnan
Tissue engineering strategies involving the in vivo delivery of recombinant growth factors are often limited by the inability of biomaterials to spatially control diffusion of the delivered protein within the site of interest. The poor spatiotemporal control provided by porous collagen sponges, which are used for the clinical delivery of bone morphogenetic protein-2 (BMP-2) for bone regeneration, has necessitated the use of supraphysiological protein doses, leading to inflammation and heterotopic ossification...
March 24, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28241263/bridging-knowledge-gaps-to-understand-how-zika-virus-exposure-and-infection-affect-child-development
#2
Bill G Kapogiannis, Nahida Chakhtoura, Rohan Hazra, Catherine Y Spong
Importance: The Zika virus (ZIKV) epidemic has profoundly affected the lives of children and families across the Americas. As the number of children born with ZIKV-related complications continues to grow, the long-term developmental trajectory for these children and the effect on their families remains largely unknown. In September 2016, the Eunice Kennedy Shriver National Institute of Child Health and Human Development and partner National Institutes of Health institutes convened a workshop to develop a research agenda to improve the evaluation, monitoring, and management of neonates, infants, or children affected by ZIKV and its complications...
February 20, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28168098/identifying-zooplankton-community-changes-between-shallow-and-upper-mesophotic-reefs-on-the-mesoamerican-barrier-reef-caribbean
#3
Dominic A Andradi-Brown, Catherine E I Head, Dan A Exton, Christina L Hunt, Alicia Hendrix, Erika Gress, Alex D Rogers
Mesophotic coral ecosystems (MCEs, reefs 30-150 m) are understudied, yet the limited research conducted has been biased towards large sessile taxa, such as scleractinian corals and sponges, or mobile taxa such as fishes. Here we investigate zooplankton communities on shallow reefs and MCEs around Utila on the southern Mesoamerican Barrier Reef using planktonic light traps. Zooplankton samples were sorted into broad taxonomic groups. Our results indicate similar taxonomic zooplankton richness and overall biomass between shallow reefs and MCEs...
2017: PeerJ
https://www.readbyqxmd.com/read/27951508/enhanced-denitrification-in-downflow-hanging-sponge-reactors-for-decentralised-domestic-wastewater-treatment
#4
Catherine A Bundy, Dong Wu, Mui-Choo Jong, Stephen R Edwards, Ziauddin S Ahammad, David W Graham
Enhanced aerobic/anoxic Downflow Hanging Sponge (DHS) bioreactors were assessed for carbon (C) and total nitrogen (TN) removal for decentralised domestic wastewater treatment applications. The initial design included upper aerobic and lower anoxic sponge layers, and effluent recirculation, and achieved >80% CODs and >90% NH4-N removal. However, effluent TN was higher. It was concluded the anoxic layer was C-limited for denitrification, therefore an influent bypass was added to the anoxic layer to provide supplemental C...
February 2017: Bioresource Technology
https://www.readbyqxmd.com/read/27870127/study-explores-cost-benefits-of-optimising-pregnancy-outcome
#5
COMMENT
Catherine Y Spong
No abstract text is available yet for this article.
2016: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/27458942/improving-birth-outcomes-key-to-improving-global-health
#6
EDITORIAL
Catherine Y Spong
No abstract text is available yet for this article.
July 26, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27383785/multiple-mechanisms-disrupt-the-let-7-microrna-family-in-neuroblastoma
#7
John T Powers, Kaloyan M Tsanov, Daniel S Pearson, Frederik Roels, Catherine S Spina, Richard Ebright, Marc Seligson, Yvanka de Soysa, Patrick Cahan, Jessica Theißen, Ho-Chou Tu, Areum Han, Kyle C Kurek, Grace S LaPier, Jihan K Osborne, Samantha J Ross, Marcella Cesana, James J Collins, Frank Berthold, George Q Daley
Poor prognosis in neuroblastoma is associated with genetic amplification of MYCN. MYCN is itself a target of let-7, a tumour suppressor family of microRNAs implicated in numerous cancers. LIN28B, an inhibitor of let-7 biogenesis, is overexpressed in neuroblastoma and has been reported to regulate MYCN. Here we show, however, that LIN28B is dispensable in MYCN-amplified neuroblastoma cell lines, despite de-repression of let-7. We further demonstrate that MYCN messenger RNA levels in amplified disease are exceptionally high and sufficient to sponge let-7, which reconciles the dispensability of LIN28B...
July 14, 2016: Nature
https://www.readbyqxmd.com/read/27268016/understanding-zika-virus-pathogenesis-an-interview-with-catherine-spong
#8
EDITORIAL
Catherine Y Spong
A recent outbreak of Zika virus has been linked to fetal abnormalities in pregnant women who have been infected. The scientific community is working toward understanding Zika virus pathogenesis to better manage affected women and children. In an interview with Dr. Catherine Spong, we discuss the aims and challenges of a forthcoming longitudinal study of a cohort of pregnant women in areas of current active Zika virus transmission.
June 6, 2016: BMC Medicine
https://www.readbyqxmd.com/read/26479151/the-spread-of-a-novel-behavior-in-wild-chimpanzees-new-insights-into-the-ape-cultural-mind
#9
Thibaud Gruber, Timothée Poisot, Klaus Zuberbühler, William Hoppitt, Catherine Hobaiter
For years, the animal culture debate has been dominated by the puzzling absence of direct evidence for social transmission of behavioral innovations in the flagship species of animal culture, the common chimpanzee. Although social learning of novel behaviors has been documented in captivity, critics argue that these findings lack ecological validity and therefore may not be relevant for understanding the evolution of culture. For the wild, it is possible that group-specific behavioral differences emerge because group members respond individually to unspecified environmental differences, rather than learning from each other...
March 2015: Communicative & Integrative Biology
https://www.readbyqxmd.com/read/26433401/figo-consensus-guidelines-on-intrapartum-fetal-monitoring-cardiotocography
#10
Diogo Ayres-de-Campos, Catherine Y Spong, Edwin Chandraharan
No abstract text is available yet for this article.
October 2015: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/26428502/the-human-placenta-project-it-s-time-for-real-time
#11
EDITORIAL
Alan E Guttmacher, Catherine Y Spong
No abstract text is available yet for this article.
October 2015: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26218593/mineral-acquisition-from-clay-by-budongo-forest-chimpanzees
#12
Vernon Reynolds, Andrew W Lloyd, Christopher J English, Peter Lyons, Howard Dodd, Catherine Hobaiter, Nicholas Newton-Fisher, Caroline Mullins, Noemie Lamon, Anne Marijke Schel, Brittany Fallon
Chimpanzees of the Sonso community, Budongo Forest, Uganda were observed eating clay and drinking clay-water from waterholes. We show that clay, clay-rich water, and clay obtained with leaf sponges, provide a range of minerals in different concentrations. The presence of aluminium in the clay consumed indicates that it takes the form of kaolinite. We discuss the contribution of clay geophagy to the mineral intake of the Sonso chimpanzees and show that clay eaten using leaf sponges is particularly rich in minerals...
2015: PloS One
https://www.readbyqxmd.com/read/26002173/prevention-of-the-first-cesarean-delivery
#13
REVIEW
Catherine Y Spong
Education of providers and patients on the importance of vaginal delivery, for the current pregnancy as well as future pregnancies, is essential to reverse the current trend of primary cesareans. When discussing cesarean with patients, counseling should include the effect on subsequent pregnancy risks including the possibility of uterine rupture and placentation abnormalities. In addition, counseling must include the concept that normal labor takes time. Re-education on the natural process of labor, the importance of allowing the time needed, and patience with the duration of pregnancy and process of labor is essential...
June 2015: Obstetrics and Gynecology Clinics of North America
https://www.readbyqxmd.com/read/25268798/social-network-analysis-shows-direct-evidence-for-social-transmission-of-tool-use-in-wild-chimpanzees
#14
Catherine Hobaiter, Timothée Poisot, Klaus Zuberbühler, William Hoppitt, Thibaud Gruber
Social network analysis methods have made it possible to test whether novel behaviors in animals spread through individual or social learning. To date, however, social network analysis of wild populations has been limited to static models that cannot precisely reflect the dynamics of learning, for instance, the impact of multiple observations across time. Here, we present a novel dynamic version of network analysis that is capable of capturing temporal aspects of acquisition--that is, how successive observations by an individual influence its acquisition of the novel behavior...
September 2014: PLoS Biology
https://www.readbyqxmd.com/read/25241107/effect-of-magnesium-sulfate-administration-for-neuroprotection-on-latency-in-women-with-preterm-premature-rupture-of-membranes
#15
RANDOMIZED CONTROLLED TRIAL
Amanda L Horton, Yinglei Lai, Dwight J Rouse, Catherine Y Spong, Kenneth J Leveno, Michael W Varner, Brian M Mercer, Jay D Iams, Ronald J Wapner, Yoram Sorokin, John M Thorp, Susan M Ramin, Fergal D Malone, Mary J O'Sullivan, Gary D V Hankins, Steve N Caritis
OBJECTIVE: This study aims to evaluate whether magnesium sulfate administration for neuroprotection prolongs latency in women with preterm premature rupture of membranes (PPROM) between 24 and 31(6/7) weeks' gestation. STUDY DESIGN: This is a secondary analysis of a randomized controlled trial of magnesium sulfate for prevention of cerebral palsy. Gravid women with a singleton pregnancy between 24 and 31(6/7) weeks' gestation with PPROM without evidence of labor were randomized to receive magnesium sulfate, administered intravenously as a 6-g bolus followed by a constant infusion of 2 g per hour up to 12 hours, or placebo...
March 2015: American Journal of Perinatology
https://www.readbyqxmd.com/read/25223501/anakinra-use-during-pregnancy-in-patients-with-cryopyrin-associated-periodic-syndromes-caps
#16
Zenas Chang, Catherine Y Spong, Adriana A Jesus, Michael A Davis, Nicole Plass, Deborah L Stone, Dawn Chapelle, Patrycja Hoffmann, Daniel L Kastner, Karyl Barron, Raphaela T Goldbach-Mansky, Pamela Stratton
Objective: To describe the pregnancy course and outcome, and use of anakinra, a recombinant selective IL-1 receptor blocker, during pregnancy in patients with cryopyrin-associated periodic syndromes (CAPS), including familial cold auto-inflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS) and neonatal onset multi-system inflammatory disease (NOMID). Methods: Women currently enrolled in natural history protocols (NCT00059748, and/or NCT00069329 under IND) who have been pregnant were included. Subjects underwent a structured, standardized interview with regards to maternal health, pregnancy and fetal outcomes...
November 2014: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/25104592/a-solution-pathway-for-preterm-birth-accelerating-a-priority-research-agenda
#17
Eve M Lackritz, Christopher B Wilson, Alan E Guttmacher, Jennifer L Howse, Cyril M Engmann, Craig E Rubens, Elizabeth M Mason, Louis J Muglia, Michael G Gravett, Robert L Goldenberg, Jeffrey C Murray, Catherine Y Spong, Joe Leigh Simpson
No abstract text is available yet for this article.
December 2013: Lancet Global Health
https://www.readbyqxmd.com/read/24839145/does-maternal-body-mass-index-influence-treatment-effect-in-women-with-mild-gestational-diabetes
#18
RANDOMIZED CONTROLLED TRIAL
Brian M Casey, Lisa Mele, Mark B Landon, Catherine Y Spong, Susan M Ramin, Ronald J Wapner, Michael W Varner, Dwight J Rouse, John M Thorp, Patrick Catalano, Margaret Harper, George Saade, Yoram Sorokin, Alan M Peaceman
OBJECTIVE: The aim of the article is to determine whether maternal body mass index (BMI) influences the beneficial effects of diabetes treatment in women with gestational diabetes mellitus (GDM). STUDY DESIGN: Secondary analysis of a multicenter randomized treatment trial of women with GDM. Outcomes of interest were elevated umbilical cord c-peptide levels (> 90th percentile 1.77 ng/mL), large for gestational age (LGA) birth weight (> 90th percentile), and neonatal fat mass (g)...
January 2015: American Journal of Perinatology
https://www.readbyqxmd.com/read/24819145/length-of-latency-with-preterm-premature-rupture-of-membranes-before-32-weeks-gestation
#19
Alan M Peaceman, Yinglei Lai, Dwight J Rouse, Catherine Y Spong, Brian M Mercer, Michael W Varner, John M Thorp, Susan M Ramin, Fergal D Malone, Mary J O'Sullivan, Gary D V Hankins
OBJECTIVE: The objective of the article is to describe latency for patients with preterm premature membrane rupture (PPROM) between 24(0/7) and 31(6/7) weeks' gestation. STUDY DESIGN: Secondary analysis of data collected prospectively in a multicenter clinical trial of magnesium sulfate for cerebral palsy prevention. Women with PPROM and fewer than six contractions per hour at enrollment who were candidates for expectant management (n = 1,377) were included in this analysis...
January 2015: American Journal of Perinatology
https://www.readbyqxmd.com/read/24561726/the-predicted-secretomes-of-monosiga-brevicollis-and-capsaspora-owczarzaki-close-unicellular-relatives-of-metazoans-reveal-new-insights-into-the-evolution-of-the-metazoan-extracellular-matrix
#20
Frederike Williams, Hannah A Tew, Catherine E Paul, Josephine C Adams
The extracellular matrix (ECM) is a major mediator of multi-cellularity in the metazoa. Multiple ECM proteins are conserved from sponges to human, raising questions about the evolutionary origin of ECM. Choanoflagellates are the closest unicellular relatives of the metazoa and proteins with domains characteristic of metazoan ECM proteins have been identified from the genome-predicted proteome of the choanoflagellate Monosiga brevicollis. However, a systematic analysis of M. brevicollis secretory signal peptide-containing proteins with ECM domains has been lacking...
July 2014: Matrix Biology: Journal of the International Society for Matrix Biology
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