Chirag M Vaswani, Amir K Varkouhi, Sahil Gupta, Amin M Ektesabi, James N Tsoporis, Sadiya Yousef, Pamela J Plant, Adriana L da Silva, Yuchen Cen, Yi-Chieh Tseng, Sabrina S Batah, Alexandre T Fabro, Suzanne L Advani, Andrew Advani, Howard Leong-Poi, John C Marshall, Cristiana C Garcia, Patricia R M Rocco, Guillermo M Albaiceta, Steffen Sebastian-Bolz, Tania H Watts, Theo J Moraes, Vera L Capelozzi, Claudia C Dos Santos
Virus-induced lung injury is associated with loss of pulmonary epithelial-endothelial tight junction integrity. While the alveolar-capillary membrane may be an indirect target of injury; viruses may interact directly and/or indirectly with miRs to augment their replication potential and evade the host antiviral defense system. Here we expose how the influenza virus (H1N1) capitalizes on host-derived interferon-induced, microRNA (miR)-193b-5p to target occludin and compromise antiviral defenses. Lung biopsies from patients infected with H1N1 revealed increased miR-193b-5p levels, marked reduction in occludin protein, and disruption of the alveolar-capillary barrier...
June 19, 2023: Molecular Therapy