Takahiro Matsui, Michiko Oka, Tomomi Fukui, Mitsushi Tanaka, Tatsuya Oyama, Koji Sagawa, Masanori Nomiya, Osamu Yamaguchi
OBJECTIVES: To clarify the mechanism by which chronic bladder ischemia causes bladder functional changes, and to investigate the involvement of oxidative stress and pro-inflammatory cytokines, and the effects of the phytotherapeutic drug, Eviprostat, on these biochemical marker levels and bladder function. METHODS: Male Sprague-Dawley rats aged 15 weeks were divided into three groups. Arterial injury was experimentally induced by balloon endothelial injury of the iliac arteries, and a 2% cholesterol diet was given for 8 weeks...
July 2012: International Journal of Urology: Official Journal of the Japanese Urological Association