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Diabetes, Hypertension, Obesity

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https://www.readbyqxmd.com/read/29342308/chronic-kidney-disease-burden-among-african-migrants-in-three-european-countries-and-in-urban-and-rural-ghana-the-rodam-cross-sectional-study
#1
David N Adjei, Karien Stronks, Dwomoa Adu, Erik Beune, Karlijn Meeks, Liam Smeeth, Juliet Addo, Ellis Owuso-Dabo, Kerstin Klipstein-Grobusch, Frank P Mockenhaupt, Matthias B Schulze, Ina Danquah, Joachim Spranger, Silver Bahendeka, Ama de-Graft Aikins, Charles Agyemang
Background: Chronic kidney disease (CKD) is a major burden among sub-Saharan African (SSA) populations. However, differences in CKD prevalence between rural and urban settings in Africa, and upon migration to Europe are unknown. We therefore assessed the differences in CKD prevalence among homogenous SSA population (Ghanaians) residing in rural and urban Ghana and in three European cities, and whether conventional risk factors of CKD explained the observed differences. Furthermore, we assessed whether the prevalence of CKD varied among individuals with hypertension and diabetes compared with individuals without these conditions...
January 12, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29341865/evidence-of-genetic-predisposition-for-metabolically-healthy-obesity-and-metabolically-obese-normal-weight
#2
Lam Opal Huang, Ruth Loos, Tuomas Oskari Kilpeläinen
Obesity has evolved into a global pandemic, which constitutes a major threat to public health. The majority of obesity-related health care costs are due to cardiometabolic complications, such as insulin resistance, dyslipidemia, and hypertension, which are risk factors for type 2 diabetes and cardiovascular disease. However, many obese individuals, often called metabolically healthy obese (MHO), seem to be protected from these cardiometabolic complications. Conversely, there is a group of individuals who suffer from cardiometabolic complications despite being of normal weight; a condition termed metabolically obese normal weight (MONW)...
December 20, 2017: Physiological Genomics
https://www.readbyqxmd.com/read/29340680/association-of-bariatric-surgery-vs-medical-obesity-treatment-with-long-term-medical-complications-and-obesity-related-comorbidities
#3
Gunn Signe Jakobsen, Milada Cvancarova Småstuen, Rune Sandbu, Njord Nordstrand, Dag Hofsø, Morten Lindberg, Jens Kristoffer Hertel, Jøran Hjelmesæth
Importance: The association of bariatric surgery and specialized medical obesity treatment with beneficial and detrimental outcomes remains uncertain. Objective: To compare changes in obesity-related comorbidities in patients with severe obesity (body mass index ≥40 or ≥35 and at least 1 comorbidity) undergoing bariatric surgery or specialized medical treatment. Design, Setting, and Participants: Cohort study with baseline data of exposures from November 2005 through July 2010 and follow-up data from 2006 until death or through December 2015 at a tertiary care outpatient center, Vestfold Hospital Trust, Norway...
January 16, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29340677/association-of-bariatric-surgery-using-laparoscopic-banding-roux-en-y-gastric-bypass-or-laparoscopic-sleeve-gastrectomy-vs-usual-care-obesity-management-with-all-cause-mortality
#4
Orna Reges, Philip Greenland, Dror Dicker, Morton Leibowitz, Moshe Hoshen, Ilan Gofer, Laura J Rasmussen-Torvik, Ran D Balicer
Importance: Bariatric surgery is an effective and safe approach for weight loss and short-term improvement in metabolic disorders such as diabetes. However, studies have been limited in most settings by lack of a nonsurgical group, losses to follow-up, missing data, and small sample sizes in clinical trials and observational studies. Objective: To assess the association of 3 common types of bariatric surgery compared with nonsurgical treatment with mortality and other clinical outcomes among obese patients...
January 16, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29340676/effect-of-laparoscopic-sleeve-gastrectomy-vs-laparoscopic-roux-en-y-gastric-bypass-on-weight-loss-at-5-years-among-patients-with-morbid-obesity-the-sleevepass-randomized-clinical-trial
#5
Paulina Salminen, Mika Helmiö, Jari Ovaska, Anne Juuti, Marja Leivonen, Pipsa Peromaa-Haavisto, Saija Hurme, Minna Soinio, Pirjo Nuutila, Mikael Victorzon
Importance: Laparoscopic sleeve gastrectomy for treatment of morbid obesity has increased substantially despite the lack of long-term results compared with laparoscopic Roux-en-Y gastric bypass. Objective: To determine whether laparoscopic sleeve gastrectomy and laparoscopic Roux-en-Y gastric bypass are equivalent for weight loss at 5 years in patients with morbid obesity. Design, Setting, and Participants: The Sleeve vs Bypass (SLEEVEPASS) multicenter, multisurgeon, open-label, randomized clinical equivalence trial was conducted from March 2008 until June 2010 in Finland...
January 16, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29340036/the-association-between-elevated-fasting-plasma-glucose-levels-and-carotid-intima-media-thickness-in-non-diabetic-adults-a-population-based-cross-sectional-study
#6
Yalin Guan, Changshen Yu, Min Shi, Jingxian Ni, Yanan Wu, Hongfei Gu, Lingling Bai, Jie Liu, Jun Tu, Jinghua Wang, Xianjia Ning
We assessed the association between the mean carotid intima-media thickness (CIMT) and fasting plasma glucose (FPG) levels in a low-income population in rural China. Adults aged ≥45 years without a history of diabetes, stroke, or cardiovascular disease were recruited. All participants were categorized into four groups according to FPG level. A total of 3509 participants were analyzed in this study. In the univariate analysis, sex, age, education level, hypertension, central obesity, current smoking, alcohol consumption, and higher levels of FPG, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were associated with mean CIMT and frequency of increased CIMT...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29339829/associations-of-the-dietary-approaches-to-stop-hypertension-dash-diet-with-pregnancy-complications-in-project-viva
#7
Aarohee P Fulay, Sheryl L Rifas-Shiman, Emily Oken, Wei Perng
BACKGROUND/OBJECTIVES: The Dietary Approaches to Stop Hypertension (DASH) diet has been shown to improve cardiometabolic outcomes in non-pregnant populations. Little is known regarding the impact of this diet on health during pregnancy. The objective of this research is to examine associations of adherence to the DASH diet with hypertensive disorders of pregnancy (HDP) and other pregnancy outcomes. SUBJECTS/METHODS: We conducted analyses with data that came from 1760 women in Project Viva, a Boston-area longitudinal cohort recruited in early pregnancy 1999-2002...
January 17, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29339240/prevalence-of-type-ii-diabetes-mellitus-among-patients-with-hidradenitis-suppurativa-in-the-united-states
#8
Amit Garg, Morgan Birabaharan, Andrew Strunk
BACKGROUND: Few studies have evaluated the relationship between hidradenitis suppurativa (HS) and diabetes mellitus (DM), and the existing data show conflicting results. OBJECTIVE: To determine prevalence of DM among HS patients, and identify at risk demographic subgroups. METHODS: Cross-sectional analysis identifying DM among HS and non-HS patients from a demographically heterogeneous population-based sample of over 50 million patients in the United States...
January 12, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29338921/faster-progression-from-mci-to-probable-ad-for-carriers-of-a-single-nucleotide-polymorphism-associated-with-type-2-diabetes
#9
Hugo Girard, Olivier Potvin, Scott Nugent, Caroline Dallaire-Théroux, Stephen Cunnane, Simon Duchesne
Sporadic Alzheimer's disease (AD), as opposed to its autosomal dominant form, is likely caused by a complex interaction of genetic, environmental, and health lifestyle factors. Twin studies indicate that sporadic AD heritability could be between 58% and 79%, around half of which is explained by the ε4 allele of the apolipoprotein E (APOE4). We hypothesized that genes associated with known risk factors for AD, namely hypertension, hypercholesterolemia, obesity, diabetes, and cardiovascular disease, would contribute significantly to the remaining heritability...
December 7, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/29338797/maternal-early-pregnancy-obesity-and-depressive-symptoms-during-and-after-pregnancy
#10
Satu M Kumpulainen, Polina Girchenko, Marius Lahti-Pulkkinen, Rebecca M Reynolds, Soile Tuovinen, Anu-Katriina Pesonen, Kati Heinonen, Eero Kajantie, Pia M Villa, Esa Hämäläinen, Hannele Laivuori, Katri Räikkönen
BACKGROUND: Previous studies have linked maternal obesity with depressive symptoms during and after pregnancy. It remains unknown whether obesity associates with consistently elevated depressive symptoms throughout pregnancy, predicts symptoms postpartum when accounting for antenatal symptoms, and if co-morbid hypertensive and diabetic disorders add to these associations. We addressed these questions in a sample of Finnish women whom we followed during and after pregnancy. METHODS: Early pregnancy body mass index, derived from the Finnish Medical Birth Register and hospital records in 3234 PREDO study participants, was categorized into underweight (<18...
January 17, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29335847/diabetes-obesity-and-the-metabolic-syndrome-as-prognostic-factors-in-stages-i-to-iii-colorectal-cancer-patients
#11
Brianna Croft, Melissa Reed, Caitlyn Patrick, Natalie Kovacevich, Ioannis A Voutsadakis
BACKGROUND: Attempts to introduce prognostic factors for survival outcomes in localized colorectal cancer patients receiving surgical treatment with or without adjuvant therapies, beyond the classic staging parameters, have been met with limited success. Obesity and diabetes mellitus are among the conditions that predispose to colorectal cancer but their value as prognostic markers once the disease is diagnosed is controversial. PATIENTS AND METHODS: This study examines the prognostic value of the components of metabolic syndrome in a retrospective series of colorectal cancer patients with stages I to III disease followed in a single center...
January 15, 2018: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29334743/-adiponectin-in-patients-with-metabolic-syndrome-and-diseases-of-the-liver-bile-ducts-and-pancreas
#12
Adam Vašura, Martin Blaho, Petr Dítě, Tomáš Kupka, Pavel Svoboda, Arnošt Martínek
Epidemiological data show that the metabolic syndrome can be diagnosed in up to 30 % of the population. Regarding 5 components of the metabolic syndrome, three of them, in case of positivity (visceral obesity, arterial hypertension, hypertriglyceridemia, changes of HDL-cholesterol levels and type 2 diabetes mellitus), are pathogenic factors which are the most frequently related to cardiovascular diseases, but currently they are also the focus of interest for gastroenterologists. The relationship between non-alcoholic hepatic steatosis, including non-alcoholic steatohepatitis, has been described...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29334717/-the-ten-year-retrospect-of-nutrition-and-health-status-of-pregnant-women-in-china
#13
C X Dong, S A Yin
Improvement of the nutrition and health status of pregnant women should be one of the top priority strategies of improving the physical fitness of next generation and reserve of talented person for national sustainable development. This paper reviews the nutrition and health status of pregnant women in China over the recent ten years and discusses the underlying factors and changing trends. The most popular nutrition-related problem is dietary imbalance, and many micronutrient intakes are lower than the recommended dietary intakes or adequate intakes, and some of nutrient intakes are still at a very low level for a long time such as vitamin D and calcium...
January 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29334265/prevalence-and-covariates-of-uncontrolled-hypertension-in-ischemic-stroke-survivors-the-norwegian-stroke-in-the-young-study
#14
Åshild Oftedal, Eva Gerdts, Ulrike Waje-Andreassen, Annette Fromm, Halvor Naess, Anja Linde, Sahrai Saeed
PURPOSE: Hypertension is the most important modifiable risk factor for stroke. Few data are available on control of hypertension in younger ischemic stroke survivors. MATERIAL AND METHODS: We assessed clinic and ambulatory blood pressure (BP) measurements in 320 patients aged 15-60 years (mean 48 ± 10) included in the Norwegian Stroke in the Young Study during 3-months follow-up after the index stroke. Controlled hypertension was defined as ambulatory BP <130/80 mmHg...
January 15, 2018: Blood Pressure
https://www.readbyqxmd.com/read/29333686/predicting-hypertension-among-korean-cancer-survivors-a-nationwide-population-based-study
#15
Y-H Kim, K-H Cho, K H Kim, E J Ryu, K D Han, J-S Kim
Hypertension is the most common comorbidity among cancer survivors, although there is no model for predicting hypertension in this population. Therefore, we developed a model for predicting hypertension using data from 6,480 Korean cancer survivors who were ≥20 years old. The odds ratios (ORs) for hypertension were calculated using stepwise logistic regression analyses, and a nomogram was generated to predict hypertension. Hypertension was independently associated with an age of ≥65 years (OR: 3.058), male gender (OR: 1...
January 15, 2018: European Journal of Cancer Care
https://www.readbyqxmd.com/read/29333506/murine-models-of-heart-failure-with-preserved-ejection-fraction-a-fishing-expedition
#16
Maria Valero-Muñoz, Warren Backman, Flora Sam
Heart failure with preserved ejection fraction (HFpEF) is characterized by signs and symptoms of HF in the presence of a normal left ventricular (LV) ejection fraction (EF). Despite accounting for up to 50% of all clinical presentations of HF, the mechanisms implicated in HFpEF are poorly understood, thus precluding effective therapy. The pathophysiological heterogeneity in the HFpEF phenotype also contributes to this disease and likely to the absence of evidence-based therapies. Limited access to human samples and imperfect animal models that completely recapitulate the human HFpEF phenotype have impeded our understanding of the mechanistic underpinnings that exist in this disease...
December 2017: JACC. Basic to Translational Science
https://www.readbyqxmd.com/read/29332673/prevalence-and-comorbidity-of-sleep-conditions-in-australian-adults-2016-sleep-health-foundation-national-survey
#17
Sarah L Appleton, Tiffany K Gill, Carol J Lang, Anne W Taylor, R Douglas McEvoy, Nigel P Stocks, David A González-Chica, Robert J Adams
OBJECTIVE: To determine the prevalence of sleep conditions (obstructive sleep apnea [OSA], insomnia symptoms, simple snoring, and restless legs) and their associated burden of chronic conditions in a community sample. DESIGN: Cross-sectional national adult online survey. SETTING: Community-based sample. PARTICIPANTS: Australian adults ≥18 years, N = 1011. MEASUREMENTS: A cross-sectional national online survey assessed diagnosed OSA, OSA symptoms, insomnia symptoms, sleep problems, excessive daytime sleepiness (Epworth Sleepiness Scale ≥11), and physician-diagnosed health conditions (heart disease, diabetes, hypertension, reflux disease, lung disease, depression, anxiety/panic disorder, arthritis)...
February 2018: Sleep Health
https://www.readbyqxmd.com/read/29330930/gender-specific-risk-factors-for-androgenetic-alopecia-in-the-korean-general-population-associations-with-medical-comorbidities-and-general-health-behaviors
#18
Bo-Kyung Kim, Sung Jay Choe, Hee-Chul Chung, Sung-Soo Oh, Won-Soo Lee
BACKGROUND: The relationships between androgenetic alopecia (AGA) and various factors related to metabolic syndrome have been demonstrated in previous studies. However, it remains unclear because of inconsistent results. We investigated the associations between AGA and various risk factors related to metabolic syndrome according to gender. METHODS: We conducted a population-based cross-sectional survey of 2028 Koreans (1050 men, 978 women). The basic and specific (BASP) classification was used for diagnosis of AGA...
February 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29330646/potential-impact-of-sglt2-inhibitors-on-left-ventricular-diastolic-function-in-patients-with-diabetes-mellitus
#19
REVIEW
Hidekazu Tanaka, Ken-Ichi Hirata
The pathogenesis of diabetes mellitus (DM)-related cardiac dysfunction is thought to be multifactorial, and possibly a key factor for the development of heart failure with preserved ejection fraction (HFpEF) in patients with DM and preserved left ventricular (LV) ejection fraction. Currently, there is no effective treatment for HFpEF, which is presented as LV diastolic dysfunction. Furthermore, it is well known that, in addition to DM, hypertension and overweight/obesity are also important factors associated with HFpEF...
January 12, 2018: Heart Failure Reviews
https://www.readbyqxmd.com/read/29325776/prevalence-of-prediabetes-and-diabetes-mellitus-among-adults-residing-in-cameroon-a-systematic-review-and-meta-analysis
#20
REVIEW
Jean Joel Bigna, Jobert Richie Nansseu, Jean-Claude Katte, Jean Jacques Noubiap
AIMS: To summarize current data on the prevalence of prediabetes and diabetes mellitus in Cameroon. METHODS: Population-based cross-sectional studies published between January 1, 2000 and April 30, 2017 including apparently healthy adults residing in Cameroon were searched in PubMed, EMBASE, African Journals Online, and African Index Medicus. We used a random-effects model to pool data. RESULTS: All included studies had a low risk of bias...
January 8, 2018: Diabetes Research and Clinical Practice
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