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Wouter C Meijers, A Rogier van der Velde, Anneke C Muller Kobold, Janneke Dijck-Brouwer, Alan H Wu, Allan Jaffe, Rudolf A de Boer
AIMS: Biomarkers can be used for diagnosis, risk stratification, or management of patients with heart failure (HF). Knowledge about the biological variation is needed for proper interpretation of serial measurements. Therefore, we aimed to determine and compare the biological variation of a large panel of biomarkers in healthy subjects and in patients with chronic HF. METHODS AND RESULTS: The biological variability of established biomarkers [NT-proBNP and high-sensitivity troponin T (hsTnT)], novel biomarkers [galectin-3, suppression of tumorigenicity 2 (ST2), and growth differentiation factor 15 (GDF-15)], and renal/neurohormonal biomarkers (aldosterone, phosphate, parathyroid hormone, plasma renin concentration, and creatinine) was determined in 28 healthy subjects and 83 HF patients, over a period of 4 months and 6 weeks, respectively...
October 21, 2016: European Journal of Heart Failure
Paul Welsh, Katie Tuckwell, Iain B McInnes, Naveed Sattar
BACKGROUND AND AIMS: Observational associations between inflammation and cardiovascular disease are interesting, but randomised experimental data are lacking. We investigated the effect of the IL-6 receptor blocker tocilizumab on N terminal pro B type natriuretic peptide (NT-proBNP) and high sensitivity troponin T (hsTnT) in rheumatoid arthritis (RA) patients. METHODS: A post-hoc study was performed in a subset of patients with moderate to severe RA participating in a randomised controlled trial...
October 8, 2016: Atherosclerosis
Matthias Heringlake, Efstratios I Charitos, Kira Erber, Astrid Ellen Berggreen, Hermann Heinze, Hauke Paarmann
BACKGROUND: Growth-differentiation factor-15 (GDF-15) is an emerging humoral marker for risk stratification in cardiovascular disease. Cardiac-surgery-associated acute kidney injury (CSA-AKI), an important complication in patients undergoing cardiac surgery, is associated with poor prognosis. The present secondary analysis of an observational cohort study aimed to determine the role of GDF-15 in predicting CSA-AKI compared with the Cleveland-Clinic Acute Renal Failure (CC-ARF) score and a logistic regression model including variables associated with renal dysfunction...
October 8, 2016: Critical Care: the Official Journal of the Critical Care Forum
R Sigurjonsdottir, S Barywani, P Albertsson, M Fu
BACKGROUND: Although the elderly comprise the majority of acute coronary syndrome (ACS) patients, limited data exist on major adverse cardiovascular events (MACEs) and quality of life (QoL). OBJECTIVES: To study MACEs and QoL prospectively in ACS patients >70years referred for coronary angiography. METHODS: A prospective observational study that included ACS patients >70years undergoing coronary angiography. The outcomes were MACEs and QoL 3years after inclusion...
November 1, 2016: International Journal of Cardiology
Wiebke M Köhler, Sandra Freitag-Wolf, Moritz Lambers, Matthias Lutz, Philip Maximilian Niemann, Rainer Petzina, Georg Lutter, Peter Bramlage, Norbert Frey, Derk Frank
AIM: Risk assessment of patients undergoing TAVI remains difficult. Biomarkers have been shown to provide potential prognostic information. Here, we aimed to analyze whether the biomarker hsTNT could be used to improve risk stratification. METHOD: We prospectively enrolled 267 patients undergoing TAVI. Biomarkers (hsTNT and NTproBNP) were measured 1 day before, 3 and 7 days post procedure. All possible prognostic factors upon survival time were analyzed by Cox regression analysis...
July 6, 2016: Cardiovascular Therapeutics
Haitham Abu Sharar, Daniel Wohlleben, Mehrshad Vafaie, Arnt V Kristen, H Christian Volz, Raffi Bekeredjian, Hugo A Katus, Evangelos Giannitsis
AIMS: We sought to evaluate rates and mechanisms of myocardial injury and type 4a myocardial infarction (MI) after an elective diagnostic coronary angiography (CAG) as detected by high-sensitivity cardiac troponin T (hsTnT) assay. METHODS AND RESULTS: Cardiac troponin concentrations were measured in consecutive patients before and after undergoing an elective CAG -with or without coronary intervention (PCI)- using an hsTnT assay. The study population consisted of 545 patients: 320 (58...
June 20, 2016: EuroIntervention
Christian M Valina, Michael Amann, Christian Stratz, Dietmar Trenk, Nikolaus Löffelhardt, Miroslav Ferenc, Franz-Josef Neumann, Willibald Hochholzer
AIMS: Elevated levels of high-sensitivity troponin are seen in a significant proportion of stable patients undergoing elective coronary assessment. Multiple variables have been associated with troponin levels. The present analysis sought to identify variables independently associated with elevations of troponin and their relative strength of association with this biomarker. METHODS AND RESULTS: Stable patients undergoing elective coronary angiography and echocardiographic assessment were enrolled...
June 20, 2016: EuroIntervention
Fredrik Hessulf, Johan Ljungberg, Per-Anders Johansson, Mats Lindgren, Johan Engdahl
BACKGROUND: Campylobacter spp. are among the most common bacterial causes of gastroenteritis world-wide and mostly follow a benign course. We report two cases of Campylobacter jejuni-associated perimyocarditis, the first two simultaneous cases published to date and the third and fourth cases over all in Sweden, and a review of the literature. CASE PRESENTATION: A previously healthy 24-yo male (A) presented at the Emergency Department(ED) with recent onset of chest pain and a 3-day history of abdominal pain, fever and diarrhoea...
2016: BMC Infectious Diseases
A S Omar, S Sudarsanan, S Hanoura, H Osman, P C Sivadasan, Y Shouman, A K Tuli, R Singh, A Al Khulaifi
No abstract text is available yet for this article.
December 2015: Intensive Care Medicine Experimental
A S Omar, S Sudarsanan, S Hanoura, H Osman, P Sivadasan, Y Shouman, A K Tuli, R Singh, A Al Khulaifi
No abstract text is available yet for this article.
December 2015: Intensive Care Medicine Experimental
Oscar H M Lundberg, Lill Bergenzaun, Jörgen Rydén, Mari Rosenqvist, Olle Melander, Michelle S Chew
BACKGROUND: Adrenomedullin and endothelin-1 are hormones with opposing effects on the cardiovascular system. Adrenomedullin acts as a vasodilator and seems to be important for the initiation and continuation of the hyperdynamic circulatory response in sepsis. Endothelin-1 is a vasoconstrictor and has been linked to decreased cardiac performance. Few studies have studied the relationship between adrenomedullin and endothelin-1, and morbidity and mortality in septic shock patients. High-sensitivity troponin T (hsTNT) is normally used to diagnose acute cardiac injury but is also prognostic for outcome in intensive care...
2016: Critical Care: the Official Journal of the Critical Care Forum
Ola Kleveland, Gabor Kunszt, Marte Bratlie, Thor Ueland, Kaspar Broch, Espen Holte, Annika E Michelsen, Bjørn Bendz, Brage H Amundsen, Terje Espevik, Svend Aakhus, Jan Kristian Damås, Pål Aukrust, Rune Wiseth, Lars Gullestad
AIMS: Interleukin-6 (IL-6) contributes to atherosclerotic plaque destabilization and is involved in myocardial injury during ischaemia-reperfusion. Interleukin-6 is therefore a potential therapeutic target in myocardial infarction (MI). We hypothesized that the IL-6 receptor antagonist tocilizumab would attenuate inflammation, and secondarily reduce troponin T (TnT) release in non-ST-elevation MI (NSTEMI). METHODS AND RESULTS: In a two-centre, double-blind, placebo-controlled trial, 117 patients with NSTEMI were randomized at a median of 2 days after symptom onset to receive placebo (n = 59) or tocilizumab (n = 58), administered as a single dose prior to coronary angiography...
August 7, 2016: European Heart Journal
Anais Bothy, Michel Hermans, Damien Gruson
BACKGROUND: Accumulating evidence suggests interactions between bone and energy metabolism in patients with type 2 diabetes (T2DM). Recently, the role of osteocalcin (OC), an osteoblast-specific protein, was suggested as a regulator of glucose metabolism and fat mass. METHODS: We determined the circulating levels of OC with two different assays in T2DM patients. The relationship of OC with established biomarkers of bone and mineral metabolism as well as biomarkers related to cardiovascular risk was also investigated...
2016: Clinical Laboratory
Kate N Thomas, James D Cotter, Michael J A Williams, André M van Rij
INTRODUCTION: Routine measurement of cardiac biomarkers such as troponin T (TnT) is recommended perioperatively, especially in high-risk vascular surgery. Long-term prognosis is worse even in those with nonspecific perioperative myocardial injury. However, a clear understanding of these biomarker profiles and how they should affect patient management is lacking. METHODS: We examined the perioperative profile of high-sensitivity TnT (hsTnT) release in 85 patients undergoing elective major vascular surgery...
May 2016: Vascular and Endovascular Surgery
Kai Xue, Juan J Gu, Qunling Zhang, Xiaojian Liu, Jiachen Wang, Xiao-Qiu Li, Jianfeng Luo, Francisco J Hernandez-Ilizaliturri, Stanley F Fernandez, Myron S Czuczman, Junning Cao, Xiaonan Hong, Ye Guo
Anthracycline-induced cardiotoxicity influences treatment selection and may negatively affect clinical outcomes in lymphoma patients. While epirubicin induced cardiotoxicity less often than the same dose of doxorubicin in breast cancer, higher doses of epirubicin are required in lymphoma regimens for equivalent efficacy. Whether a higher dosage of epirubicin also induces cardiotoxicity less often than doxorubicin in lymphoma remains unknown. We therefore administered 6-8 cycles of cyclophosphamide, vincristine and prednisone (CEpOP) +/- rituximab (R) with either epirubicin (CEpOP) or doxorubicin (CHOP) to patients (N=398) with untreated diffuse large B-cell lymphoma (DLBCL) or follicular lymphoma grade 3 (FLG3)...
May 31, 2016: Oncotarget
Kate N Thomas, James D Cotter, Michael J A Williams, André M van Rij
OBJECTIVES: Remote ischemic preconditioning (RIPC) involves the phenomenon whereby transient episodes of limb ischemia induced by cuff inflation provide cardioprotection. The effectiveness of RIPC in vascular surgery is uncertain. This randomized, controlled trial was designed to investigate the potential of two episodes of RIPC to provide myocardial protection in patients undergoing vascular surgery. DESIGN AND METHODS: Patients undergoing an elective major vascular procedure (open abdominal aortic aneurysm (AAA) repair, endovascular aneurysm repair, and lower-limb bypass grafting) were randomized into RIPC group (n = 42) or control group (n = 43)...
April 2016: Vascular and Endovascular Surgery
Peter S Pang, John R Teerlink, Adriaan A Voors, Piotr Ponikowski, Barry H Greenberg, Gerasimos Filippatos, G Michael Felker, Beth A Davison, Gad Cotter, Joshua Kriger, Margaret F Prescott, Tsushung A Hua, Thomas Severin, Marco Metra
OBJECTIVES: The aim of this study was to determine if a baseline high-sensitivity troponin T (hsTnT) value ≤99th percentile upper reference limit (0.014 μg/l ["low hsTnT"]) identifies patients at low risk for adverse outcomes. BACKGROUND: Approximately 85% of patients who present to emergency departments with acute heart failure are admitted. Identification of patients at low risk might decrease unnecessary admissions. METHODS: A post-hoc analysis was conducted from the RELAX-AHF (Serelaxin, Recombinant Human Relaxin-2, for Treatment of Acute Heart Failure) trial, which randomized patients within 16 h of presentation who had systolic blood pressure >125 mm Hg, mild to moderate renal impairment, and N-terminal pro-brain natriuretic peptide ≥1,600 ng/l to serelaxin versus placebo...
July 2016: JACC. Heart Failure
Ali Buturak, Aleks Degirmencioglu, Ozgur Surgit, Ali Rıza Demir, Huseyin Karakurt, Mehmet Erturk, Selcuk Yazıcı, Mustafa Serteser, Tugrul Norgaz, Sevket Gorgulu
INTRODUCTION: The new definition of periprocedural myocardial infarction (type 4a MI) excludes patients without angina and electrocardiographic or echocardiographic changes suggestive of myocardial ischemia even though significant serum troponin elevations occur following percutaneous coronary intervention (PCI). AIM: To evaluate the incidence and predictors of serum troponin rise following elective PCI in patients without clinical and procedural signs suggestive of myocardial necrosis by using a high-sensitivite troponin assay (hsTnT)...
2016: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
Henrik Engblom, Einar Heiberg, David Erlinge, Svend Eggert Jensen, Jan Erik Nordrehaug, Jean-Luc Dubois-Randé, Sigrun Halvorsen, Pavel Hoffmann, Sasha Koul, Marcus Carlsson, Dan Atar, Håkan Arheden
BACKGROUND: Cardiac magnetic resonance (CMR) can quantify myocardial infarct (MI) size and myocardium at risk (MaR), enabling assessment of myocardial salvage index (MSI). We assessed how MSI impacts the number of patients needed to reach statistical power in relation to MI size alone and levels of biochemical markers in clinical cardioprotection trials and how scan day affect sample size. METHODS AND RESULTS: Controls (n=90) from the recent CHILL-MI and MITOCARE trials were included...
March 2016: Journal of the American Heart Association
Rohit M Oemrawsingh, Jin M Cheng, Héctor M García-García, Isabella Kardys, Ron H N van Schaik, Evelyn Regar, Robert-Jan van Geuns, Patrick W Serruys, Eric Boersma, K Martijn Akkerhuis
BACKGROUND AND AIMS: To assess the relationship between the extent and phenotype of coronary atherosclerosis, as assessed by in-vivo grayscale and radiofrequency intravascular ultrasound (IVUS), and circulating Troponin levels in patients with established stable coronary artery disease (CAD). METHODS: In this single-center, cross-sectional analysis, high-sensitivity Troponin T (hsTnT) was measured and IVUS was performed in a predefined non-stenotic segment of a non-culprit coronary artery in 231 patients with stable CAD undergoing elective angiography...
April 2016: Atherosclerosis
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