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https://www.readbyqxmd.com/read/28449252/serum-phosphorus-levels-and-fracture-following-renal-transplantation
#1
Jasna Aleksova, Phillip Wong, William R Mulley, Kay Weng Choy, Robert McLachlan, Peter R Ebeling, Peter G Kerr, Frances Milat
PURPOSE: Increased fracture rates are observed in renal transplant recipients (RTRs) compared with the general population. Risk factors include age, diabetes, dialysis vintage, immunosuppression, and mineral and bone disorders(1). Low serum phosphorus levels occur post-transplantation; however its relationship with fracture risk has not been evaluated. The purpose of this study was to evaluate risk factors for fracture in RTRs at a single tertiary referral centre. METHODS: A retrospective cross-sectional analysis of 146 patients (75M, 71F) who had been referred for dual energy x-ray densitometry (DXA) post-renal transplantation was performed...
April 27, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28446830/bryophyllum-pinnatum-leaf-extracts-prevent-formation-of-renal-calculi-in-lithiatic-rats
#2
Mahendra Yadav, Vijay D Gulkari, Manish M Wanjari
BACKGROUND: Bryophyllum pinnatum, commonly known as Pattharcaṭṭa, is used traditionally in ethnomedicinal practices for the treatment of kidney stone and urinary insufficiency. AIM: The present study evaluated the effect of Bryophyllum pinnatum on ethylene glycol (EG)-induced renal calculi in rats. MATERIALS AND METHODS: Renal calculi were induced in rats by administration of 0.75% EG in drinking water and co-treated orally with standard drug, Cystone (750 mg/kg), or alcoholic and hydro-alcoholic extracts in doses of 100, 200 and 400 mg/kg for 28 days...
October 2016: Ancient Science of Life
https://www.readbyqxmd.com/read/28445887/use-of-phosphorus-binders-among-non-dialysis-chronic-kidney-disease-patients-and-mortality-outcomes
#3
Simran K Bhandari, In-Lu A Liu, Dean A Kujubu, Trung Huynh, Hind Behayaa, Csaba P Kovesdy, Kamyar Kalantar-Zadeh, Steven J Jacobsen, John J Sim
BACKGROUND: Whether the benefits of phosphorus binders extend to those without end stage renal disease is uncertain. Among a large diverse non-dialysis chronic kidney disease (CKD) population with hyperphosphatemia, we sought to evaluate phosphorus binder use and compare mortality risk between patients prescribed and not prescribed binders. METHODS: A retrospective cohort study within an integrated health system (January 1, 1998 - December 31, 2012) among CKD patients (age ≥18) was performed...
April 27, 2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/28445300/malignant-phosphaturic-mesenchymal-tumor-with-pulmonary-metastasis-a-case-report
#4
Shui Qiu, Li-Li Cao, Yue Qiu, Ping Yan, Zi-Xuan Li, Jiang Du, Li-Mei Sun, Qing-Fu Zhang
RATIONALE: Phosphaturic mesenchymal tumor (PMT) is a new tumor entity of soft tissue and bone tumor recently accepted by the World Health Organization, which typically causes the paraneoplastic syndrome of tumor-induced osteomalacia (TIO). The majority of PMTs follow a benign clinical course and local recurrence occurs in < 10% of cases, malignant PMTs with distant organ metastasis are extremely uncommon. PATIENT CONCERNS: We reported a 41-year-old woman who was diagnosed with PMT 10 years ago with a repeated recurrence and pulmonary metastasis...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28443031/the-high-calcium-high-phosphorus-rescue-diet-is-not-suitable-to-prevent-secondary-hyperparathyroidism-in-vitamin-d-receptor-deficient-mice
#5
Sarah M Grundmann, Corinna Brandsch, Daniela Rottstädt, Hagen Kühne, Gabriele I Stangl
The vitamin D receptor (VDR) knockout (KO) mouse is a common model to unravel novel metabolic functions of vitamin D. It is recommended to feed these mice a high calcium (2%), high phosphorus (1.25%) diet, termed rescue diet (RD) to prevent hypocalcaemia and secondary hyperparathyroidism. First, we characterized the individual response of VDR KO mice to feeding a RD and found that the RD was not capable of normalizing the parathyroid hormone (PTH) concentrations in each VDR KO mouse. In a second study, we aimed to study whether RD with additional 1 and 2% calcium (in total 3 and 4% of the diet) is able to prevent secondary hyperparathyroidism in the VDR KO mice...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28439382/association-between-adiponectin-and-insulin-resistance-in-diabetic-urolithiasis
#6
Dona Devasia, Kavitha Meiyappan, Palani Selvam Mohanraj, Dorairajan Lalgudi Narayanan, Gandhipuram Periyasamy Senthilkumar, Md Yasir
OBJECTIVES: The prevalence of urolithiasis is increasing worldwide. Diabetes mellitus (DM) is characterized by insulin resistance, which increases the risk of kidney stone formation. Adiponectin is an insulin-sensitizing and anti-inflammatory cytokine, which is known to improve glucose tolerance and insulin resistance in humans. The association of insulin and adiponectin with kidney stones is not clear. Hence, the present study aim to assess the serum levels of adiponectin and insulin resistance in DM patients with urolithiasis in comparison to those without...
March 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/28429907/seasonal-vitamin-d-and-bone-metabolism-in-women-of-reproductive-age-in-urban-beijing
#7
Liying Yang, Wei Zhang
BACKGROUND AND OBJECTIVES: This study aimed to evaluate the relationship between serum 25-hydroxy-vitamin D and bone metabolism in healthy women of reproductive age. METHODS AND STUDY DESIGN: This study included 100 healthy female residents of Beijing (23-30 years old), who underwent bone ultrasonography as well as testing to evaluate serum25-hydroxy-vitamin D, parathyroid hormone, bone alkaline phosphatase, calcium, sodium, phosphorus, and alkaline phosphatase...
May 2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28428168/testing-the-feasibility-and-usability-of-a-novel-smartphone-based-self-management-support-system-for-dialysis-patients-a-pilot-study
#8
Aki Hayashi, Satoko Yamaguchi, Kayo Waki, Katsuhito Fujiu, Norio Hanafusa, Takahiro Nishi, Hyoe Tomita, Haruka Kobayashi, Hideo Fujita, Takashi Kadowaki, Masaomi Nangaku, Kazuhiko Ohe
BACKGROUND: Diet and fluid restrictions that need continuous self-management are among the most difficult aspects of dialysis treatment. Smartphone applications may be useful for supporting self-management. OBJECTIVE: Our objective is to investigate the feasibility and usability of a novel smartphone-based self-management support system for dialysis patients. METHODS: We developed the Self-Management and Recording System for Dialysis (SMART-D), which supports self-monitoring of three mortality-related factors that can be modified by lifestyle: interdialytic weight gain and predialysis serum potassium and phosphorus concentrations...
April 20, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28425622/targeted-disruption-of-nf1-in-osteocyte-increases-fgf23-and-osteoid-with-osteomalacia-like-bone-phenotype
#9
Nobuhiro Kamiya, Ryosuke Yamaguchi, Olumide Aruwajoye, Audrey Kim, Gen Kuroyanagi, Matthew Phipps, Naga Suresh Adapala, Jian Q Feng, Harry K W Kim
Neurofibromatosis type 1 (NF1, OMIM 162200), caused by NF1 gene mutations, exhibits multi-system abnormalities including skeletal deformities in humans. Osteocytes play critical roles in controlling bone modeling and remodeling. However, the role of neurofibromin, the protein product of the NF1 gene, in osteocytes is largely unknown. This study investigated the role of neurofibromin in osteocytes by disrupting Nf1 under the Dmp1-promoter. The conditional knockout (Nf1 cKO) mice displayed serum profile of a metabolic bone disorder with an osteomalacia-like bone phenotype...
April 20, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28419560/fibroblast-growth-factor-23-concentration-in-dogs-with-chronic-kidney-disease
#10
L M Harjes, V J Parker, K Dembek, G S Young, L H Giovaninni, M M Kogika, D J Chew, R E Toribio
BACKGROUND: Chronic kidney disease (CKD) is associated with hyperphosphatemia, decreased vitamin D metabolite concentrations, and hyperparathyroidism. This syndrome is known as CKD-mineral bone disorder (CKD-MBD). Recently, it has been shown that an increase in fibroblast growth factor-23 (FGF-23) concentration is an early biomarker of CKD in people. It is an independent risk factor for both progression of renal disease and survival time in humans and cats with CKD. Information about FGF-23 in healthy dogs and those with CKD is lacking...
April 17, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28414758/early-dialysis-initiation-does-not-improve-clinical-outcomes-in-elderly-end-stage-renal-disease-patients-a-multicenter-prospective-cohort-study
#11
MULTICENTER STUDY
Jae Yoon Park, Kyung Don Yoo, Yong Chul Kim, Dong Ki Kim, Kwon Wook Joo, Shin-Wook Kang, Chul Woo Yang, Nam-Ho Kim, Yong-Lim Kim, Chun-Soo Lim, Yon Su Kim, Jung Pyo Lee
BACKGROUND: The optimal timing for initiating dialysis in end-stage renal disease (ESRD) is controversial, especially in the elderly. METHODS: 665 patients ≥65 years old who began dialysis from August 2008 to February 2015 were prospectively enrolled in the Clinical Research Center for End-Stage Renal Disease cohort study. Participants were divided into 2 groups based on the median estimated glomerular filtration rate at the initiation of dialysis. Propensity score matching (PSM) was used to compare the overall survival rate, cardiovascular events, Kidney Disease Quality of Life Short Form 36 (KDQOL-36) results, Karnofsky performance scale values, Beck's depression inventory values, and subjective global assessments...
2017: PloS One
https://www.readbyqxmd.com/read/28407138/calcium-and-bone-turnover-markers-in-acromegaly-a-prospective-controlled-study
#12
Tina Constantin, Vin Tangpricha, Reshma Shah, Nelson M Oyesiku, Octavian C Ioachimescu, James Ritchie, Adriana G Ioachimescu
Context: Acromegaly has been associated with calcium-phosphate and bone turnover alterations. Controlled studies of these interactions are sparse. Objective: To evaluate calcium and bone metabolism in active and treated acromegaly. Design/Setting/Patients: We conducted a controlled prospective study at a tertiary referral center. We studied 22 patients with acromegaly referred for surgical or medical therapy (ACM) and 22 with nonfunctioning pituitary adenomas referred for surgery (control)...
April 12, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28406084/evidence-that-tmp-gfr-can-be-estimated-with-the-walton-bijvoet-nomogram-in-chronic-kidney-disease%C3%A2
#13
Kenneth R Phelps, Darius L Mason
BACKGROUND: The Walton--Bijvoet nomogram incorporates the assumption that GFR = creatinine clearance (Ccr). It determines phosphate tubular maximum per volume of filtrate (TmP/GFR) from serum phosphorus ([P]s) and fractional excretion of P (FEP), and equates TmP/GFR with actual reabsorption per volume of filtrate (TRP/Ccr) at FEP ≥ 20%. It has not been validated in chronic kidney disease (CKD). METHODS: We studied 28 controls and 30 patients with stages 3 - 4 CKD...
April 13, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/28400827/effects-of-vitamin-d-deficiency-treatment-on-metabolic-markers-in-hashimoto-thyroiditis-patients
#14
Parichehr Vahabi Anaraki, Ashraf Aminorroaya, Massoud Amini, Awat Feizi, Bijan Iraj, Azamosadat Tabatabaei
BACKGROUND: The aim of the current trial was to investigate the effect of Vitamin D treatment on metabolic markers in people with Vitamin D deficiency and thyroid autoimmunity. MATERIALS AND METHODS: In this double-blind, randomized, placebo-controlled clinical trial, 65 Vitamin D deficient euthyroid or hypothyroid patients with positive TPO-Ab were enrolled. They randomly allocated into two groups to receive oral Vitamin D3 (50000 IU weekly) and placebo for 12 weeks...
2017: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/28388981/application-and-effect-of-mobiletype-bone-health-intervention-in-korean-young-adult-women-with-low-bone-mass-a-randomized-control-trial
#15
Young-Joo Park, Sook-Ja Lee, Nah-Mee Shin, Hyunjeong Shin, Songi Jeon, Jungwoo Lee, Inhae Cho
PURPOSE: This randomized control trial was designed to examine the effect on the self-managing ability for promoting bone health of mobile type-bone health intervention (mobile type-BHI). METHODS: The mobile type-BHI consisted of a mobile application called "Strong bone, Fit body" (SbFb) and group education. A total of 82 college women with low bone mass (Z score < -1) participated. They were assigned randomly to three groups, experimental group I, (n = 28), experimental group II (n = 32), and control group (n = 22)...
March 2017: Asian Nursing Research
https://www.readbyqxmd.com/read/28384917/delayed-post-surgical-hypoparathyroidism-the-forgotten-chameleon
#16
Sangita Deepak Kamath, Balllamudi Srinivas Rao
Delayed hypoparathyroidism, due to accidental gland removal or ischemia of parathyroids can present many years after thyroidectomy and symptoms may be non-specific. This condition, if not diagnosed timely, may prove fatal and have serious consequences. Hence, clinicians must have a high index of suspicion to treat this condition. All patients with a history of previous thyroid surgery, who come with vague symptoms like fatigue, muscle aches should undergo estimation of serum calcium, phosphorus and Parathyroid Hormone (PTH) due to the lack of any pathognomonic features of hypoparathyroidism...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28378273/impact-of-air-pollution-on-vitamin-d-deficiency-and-bone-health-in-adolescents
#17
Elham Feizabad, Arash Hossein-Nezhad, Zhila Maghbooli, Majid Ramezani, Roxana Hashemian, Syamak Moattari
The association between air pollution and bone health was evaluated in adolescents in the city of Tehran. This study is essentially ecological. Vitamin D deficiency among adolescents has been reported at higher rates in polluted areas than in non-polluted areas. Additionally, residence in polluted areas is associated with lower levels of bone alkaline phosphatase. PURPOSE: The aim of this study was to evaluate the association between ambient air pollution and bone turnover in adolescents and to compare the prevalence of vitamin D deficiency between polluted and non-polluted areas of Tehran...
December 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28378123/secondary-hyperparthyroidism-pathogenesis-diagnosis-preventive-and-therapeutic-strategies
#18
REVIEW
Mariano Rodríguez Portillo, María E Rodríguez-Ortiz
Uremic secondary hyperparathyroidism is a multifactorial and complex disease often present in advanced stages of chronic kidney disease. The accumulation of phosphate, the increased FGF23 levels, the reduction in active vitamin D production, and the tendency to hypocalcemia are persistent stimuli for the development and progression of parathyroid hyperplasia with increased secretion of PTH. Parathyroid proliferation may become nodular mainly in cases of advanced hyperparathyroidism. The alterations in the regulation of mineral metabolism, the development of bone disease and extraosseous calcifications are essential components of chronic kidney disease-mineral and bone disorder and have been associated with negative outcomes...
March 2017: Reviews in Endocrine & Metabolic Disorders
https://www.readbyqxmd.com/read/28372562/aqueous-extract-of-peperomia-pellucida-l-hbk-accelerates-fracture-healing-in-wistar-rats
#19
Ngueguim Tsofack Florence, Sakouong Talle Suewellyne Huguette, Donfack Jean Hubert, Gounoue Kamkumo Raceline, Dzeufiet Djomeni Paul Desire, Kamtchouing Pierre, Dimo Theophile
BACKGROUND: Peperomia pellucida (L.) HBK is consumed as vegetable and used in Cameroonian traditional medicine for the management of diseases and for fracture healing. Therefore the aim of this study was to evaluate the effects of the aqueous whole plant extract of Peperomia pellucida on fracture healing in female Wistar rats. METHODS: A drill hole injury was created by inserting a drill bit inthe diaphysis of the femur. The aqueous extract of the whole plant of Peperomia pellucida was administered orally at the doses of 100, 200 and 400 mg/kg to adult female Wistar rats...
April 4, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28370958/diminished-disease-progression-rate-in-a-chronic-kidney-disease-population-following-the-replacement-of-dietary-water-source-with-quality-drinking-water-a-pilot-study
#20
Edirisinghe Arachchige Ranga Iroshanie Edirisinghe Siriwardhana, Ponnamperuma Aratchige Jayasumana Perera, Ramiah Sivakanesan, Tilak Abeysekara, Danaseela Bandara Nugegoda, Kosala Weerakoon, Dunusingha Asitha Surandika Siriwardhana
AIM: Environmental toxin/s is alleged to be the contributory factor for the chronic kidney disease of unknown etiology (CKDu) in Sri Lanka. The potential of drinking water as a medium for the nephrotoxic agents in the affected subjects has been comprehensively discoursed in the recent past. The present study was aimed to assess the effect of replacing the habitual drinking water on the kidney function of CKDu patients residing in the North Central Province of Sri Lanka: METHODS: An interventional study was carried out to assess the disease progression rate of a CKDu population whose habitual drinking water was replaced by bottled spring water certified by Sri Lanka Standard (SLS) for a period of 18 month along with a population of CKDu patients who continued with their usual drinking water...
March 29, 2017: Nephrology
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