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https://www.readbyqxmd.com/read/29665846/correlation-of-serum-levels-of-fibroblast-growth-factor-23-and-klotho-protein-levels-with-bone-mineral-density-in-maintenance-hemodialysis-patients
#1
Shubei Zheng, Yan Chen, Yu Zheng, Zhihong Zhou, Zhanyuan Li
OBJECTIVE: The correlation of serum fibroblast growth factor 23 (FGF-23) and Klotho protein levels with bone mineral density (BMD) in maintenance hemodialysis (MHD) patients was analyzed. METHODS: Between January 2015 and November 2015, 125 MHD patients in our hospital were enrolled. Dual-energy X-ray absorptiometry was used to examine the BMD in the femoral neck and lumbar spine of MHD patients. The patients were divided into three groups: a normal bone mass group, an osteopenia group, and an osteoporosis group...
April 17, 2018: European Journal of Medical Research
https://www.readbyqxmd.com/read/29664315/potential-correlation-between-circulating-fetuin-a-and-pentraxin-3-with-biochemical-parameters-of-calcification-in-hemodialysis-patients
#2
Javad Hashemi, Hamid-Reza Joshaghani, Arash Akaberi, Zahra Hesari, Reza Ghanbari, Mohsen Mohammadzadeh, Ali-Reza Golshan
BACKGROUND: The strong correlation between vascular calcification and cardiovascular risk, which is a major cause of mortality in hemodialysis (HD) patients, has been well established. Fetuin-A is an inhibitor of vascular calcification, and pentraxin 3 (PTX3) is produced at the site of inflammation, which is associated with cardiovascular disease (CVD). The main purpose of this study was evaluating the correlation between fetuin-A and PTX3 with some biochemical parameters effective upon vascular calcification in HD patients...
December 1, 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/29660161/the-fgf-23-klotho-axis-and-its-relationship-with-phosphorus-calcium-vitamin-d-pth-aldosterone-severity-of-disease-and-outcome-in-hospitalised-foals
#3
A M Kamr, K A Dembek, B E Hildreth, P R Morresey, R A Rathgeber, T A Burns, A A Zaghawa, R E Toribio
BACKGROUND: Fibroblast growth factor-23 (FGF-23) and klotho are key regulators of vitamin D and parathyroid hormone (PTH) synthesis as well as phosphorus and calcium homeostasis; however, information on the FGF-23/klotho axis in healthy and hospitalised foals is lacking. OBJECTIVES: The aims of this study were to measure serum FGF-23 and klotho concentrations and determine their association with serum phosphorus, total calcium (TCa), vitamin D metabolite [25(OH)D, 1,25(OH)2 D], PTH, and aldosterone concentrations, disease severity, and mortality in hospitalised foals...
April 16, 2018: Equine Veterinary Journal
https://www.readbyqxmd.com/read/29658832/the-associations-between-hypovitaminosis-d-higher-pth-levels-with-bone-mineral-densities-and-risk-of-the-10-year-probability-of-major-osteoporotic-fractures-in-chinese-patients-with-t2dm
#4
Xiao-Feng Wang, Jing-Jia Yu, Xiao-Jing Wang, Yi-Xuan Jing, Li-Hao Sun, Bei Tao, Wei-Qing Wang, Guang Ning, Jian-Min Liu, Hong-Yan Zhao
OBJECTIVE: In the current study, we investigated the vitamin D status, and its relationships with parathyroid hormone (PTH) levels, bone mineral density (BMD), and the 10-year probability of fractures in Chinese patients with type 2 diabetes mellitus (T2DM). METHODS: This was a cross-sectional study of 785 patients. BMDs at the lumbar spine (L2-4), femoral neck (FN), and total hip (TH) were measured by dual-energy X-ray absorptiometry (DXA). Serum levels of 25-hydroxyvitamin D (25(OH)D) and intact PTH were also quantified...
April 2018: Endocrine Practice
https://www.readbyqxmd.com/read/29657194/association-of-brucellosis-with-renal-tubular-and-glomerular-damage-in-children-in-turkey
#5
Secil Conkar, Muhammed Kosker, Saliha Cevik, Muzeyyen Ay
Brucellosis is a multisystem disease that may present with a broad spectrum of clinical manifestations. Until now, no studies have been performed on renal tubular disorders in patients with brucellosis. The present study aims to investigate renal tubular disorders in patients with brucellosis. This prospective case-control study includes a total of 31 brucellosis patients (Group 1) and 30 healthy controls (Group 2) matched for age and sex. Renal tubular functions of children who were diagnosed as having brucellosis in outpatient pediatric clinics were evaluated...
March 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29656600/long-term-efficacy-and-safety-of-sucroferric-oxyhydroxide-in-african-american-dialysis-patients
#6
Stuart M Sprague, Markus Ketteler, Adrian C Covic, Jürgen Floege, Viatcheslav Rakov, Sebastian Walpen, Anjay Rastogi
INTRODUCTION: Sucroferric oxyhydroxide (SFOH) is a non-calcium, iron-based phosphate binder that demonstrated sustained serum phosphorus (sP) control, good tolerability, and lower pill burden, vs. sevelamer carbonate ("sevelamer"), in a Phase 3 study conducted in dialysis patients with hyperphosphatemia. This analysis evaluates the efficacy and safety of SFOH and sevelamer among African American (AA) patients participating in the trial. METHODS: Post hoc analysis of a 24-week, Phase 3, open-label trial (NCT01324128) and its 28-week extension study (NCT01464190)...
April 15, 2018: Hemodialysis International
https://www.readbyqxmd.com/read/29655832/serum-magnesium-phosphorus-and-calcium-levels-and-subclinical-calcific-aortic-valve-disease-a-population-based-study
#7
Takashi Hisamatsu, Katsuyuki Miura, Akira Fujiyoshi, Aya Kadota, Naoko Miyagawa, Atsushi Satoh, Maryam Zaid, Takashi Yamamoto, Minoru Horie, Hirotsugu Ueshima
BACKGROUND AND AIMS: Calcific aortic valve disease (CAVD) is the most common valve disease. Although micronutrients are known to contribute to cardiovascular disease, the relationship with CAVD remains poorly evaluated. We examined the association of serum levels of magnesium, phosphorus, and calcium with prevalence, incidence, and progression of aortic valve calcification (AVC). METHODS: We conducted a prospective study in a population-based sample of Japanese men aged 40-79 years without known cardiovascular disease and chronic kidney disease at baseline, and quantified AVC from serial computed tomographic images with the Agatston method...
March 22, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29649273/do-all-infants-need-vitamin-d-supplementation
#8
Ane Cristina Fayão Almeida, Francisco José Albuquerque de Paula, Jacqueline Pontes Monteiro, Carlos Alberto Nogueira-de-Almeida, Luiz Antonio Del Ciampo, Davi Casale Aragon, Ivan Savioli Ferraz
A high prevalence of vitamin D deficiency (VDD) in children has been observed worldwide, but there are few studies on the nutritional status of vitamin D (VD) in healthy infants. The main cause of deficiency in healthy children is breastfeeding without supplementation and lack or insufficiency of sun exposure. The aims of this study were to determine serum concentrations of 25(OH)D and verify its association with parathyroid hormone (PTH) concentrations and use of VD supplementation in healthy infants aged ≥ 6 to ≤ 24 months attended at two Primary Health Care Units in Ribeirão Preto city, São Paulo, Brazil...
2018: PloS One
https://www.readbyqxmd.com/read/29629279/effects-of-education-on-low-phosphate-diet-and-phosphate-binder-intake-to-control-serum-phosphate-among-maintenance-hemodialysis-patients-a-randomized-controlled-trial
#9
Eunsoo Lim, Sunah Hyun, Jae Myeong Lee, Seirhan Kim, Min-Jeong Lee, Sun-Mi Lee, Ye-Sung Oh, Inwhee Park, Gyu-Tae Shin, Heungsoo Kim, Donald E Morisky, Jong Cheol Jeong
Background: For phosphate control, patient education is essential due to the limited clearance of phosphate by dialysis. However, well-designed randomized controlled trials about dietary and phosphate binder education have been scarce. Methods: We enrolled maintenance hemodialysis patients and randomized them into an education group (n = 48) or a control group (n = 22). We assessed the patients' drug compliance and their knowledge about the phosphate binder using a questionnaire...
March 2018: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/29627829/effect-of-lanthanum-carbonate-on-all-cause-mortality-in-patients-receiving-maintenance-hemodialysis-a-meta-analysis-of-randomized-controlled-trials
#10
Fang Wang, Xiangxue Lu, Jingli Zhang, Ruifang Xiong, Han Li, Shixiang Wang
BACKGROUND/AIMS: Hyperphosphatemia is common in patients on hemodialysis. The efficacy of lanthanum carbonate (LC) in the treatment of hyperphosphatemia in these patients remains controversial. The objective of this meta-analysis was to evaluate the effect of LC on all-cause mortality in patients on maintenance hemodialysis. METHODS: We electronically searched the PubMed, EMBASE, and Cochrane Library databases for all randomized controlled trials (RCTs) comparing LC with other phosphate binders used in adult hemodialysis patients, including calcium carbonate, calcium acetate, and sevelamer...
March 29, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29623690/observation-about-phosphorus-and-protein-supply-in-cats-and-dogs-prior-to-the-diagnosis-of-chronic-kidney-disease
#11
L F Böswald, E Kienzle, B Dobenecker
There is evidence that nutritional phosphorus (P) excess may be a risk factor for chronic kidney disease (CKD) in humans and pets (Advances in Nutrition: An International Review Journal (2014), 5, 104; The American Journal of Clinical Nutrition, (2013), 98, 6; Journal of Feline Medicine and Surgery, (2017); The source of phosphorus influences serum PTH, apparent digestibility and blood levels of calcium and phosphorus in dogs fed high phosphorus diets with balanced Ca/P ratio. Proc. Waltham International Nutritional Sciences Symposium, USA; Clinical aspects of natural and added phosphorus in foods, 2017, Springer Science+Business, Media)...
April 2018: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29622969/relationship-between-serum-osteoprotegerin-and-vascular-calcifications-in-hemodialysis-patients
#12
Tarek Z El Baz, Osama A Khamis, Amal El-Shehaby, Hussein Chahine, Ahmad Alaa Al-Din Ahmed, Mostafa A Alsawasany
Background: Uremia is a vasculopathic process, and both cardiac calcification and vascular calcification seen from the early stages of chronic kidney disease. Osteoprotegerin could play a crucial role in atherosclerotic plaque formation, maturation and calcification. The goal of this study was to determine the relationship of serum osteoprotegerin with vascular calcification in patients with end stage kidney disease who were maintained on regular hemodialysis. Methods: Sixty clinically stable chronic renal failure patients undergoing regular hemodialysis were enrolled in this cross sectional study...
June 2017: The Egyptian heart journal: (EHJ): official bulletin of the Egyptian Society of Cardiology
https://www.readbyqxmd.com/read/29621752/fibroblast-growth-factor-23-a-biomarker-of-kidney-function-decline
#13
David A Drew, Ronit Katz, Stephen Kritchevsky, Joachim H Ix, Michael G Shlipak, Anne B Newman, Andy Hoofnagle, Linda Fried, Mark J Sarnak, Orlando M Gutierrez
BACKGROUND: Fibroblast growth factor 23 (FGF-23) is a hormone that regulates phosphorus levels and vitamin D metabolism. Previous studies have shown FGF-23 to be a risk factor for incident end-stage renal disease; however, there are less data on the association of FGF-23 with earlier kidney-related outcomes. METHODS: Serum FGF-23 was assayed using an intact ELISA assay in 2,496 participants of the Healthy Aging and Body Composition Study, a cohort of well-functioning older adults...
April 5, 2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29619868/fibroblast-growth-factor-23-is-a-strong-predictor-of-insulin-resistance-among-chronic-kidney-disease-patients
#14
Ahmed Fayed, Mahmoud M El Nokeety, Ahmed A Heikal, Dina O Abdulazim, Mervat M Naguib, Usama A A Sharaf El Din
Insulin resistance (IR) is very common among chronic kidney disease (CKD) patients. Disturbance in mineral and bone metabolism (MBD) seems to play a role in the pathogenesis of insulin resistance. Fibroblast growth factor-23 (FGF23) is evolving as the most important link between MBD and many pathologic sequences of CKD. The aim was to evaluate IR in pre-dialysis CKD patients looking for a possible association to mineral metabolism among CKD patients. A total of 100 stage 3-5 CKD patients were selected beside 20 normal control subjects...
November 2018: Renal Failure
https://www.readbyqxmd.com/read/29619067/a-hop-extract-lifenol%C3%A2-improves-postmenopausal-overweight-osteoporosis-and-hot-flash-in-ovariectomized-rats
#15
Young-Hwan Ban, Jung-Min Yon, Yeseul Cha, Jieun Choi, Eun Suk An, Haiyu Guo, Da Woom Seo, Tae-Su Kim, Sung-Pyo Lee, Jong-Choon Kim, Ehn-Kyoung Choi, Yun-Bae Kim
Objective: In order to assess the effectiveness of a hop extract (HE) for postmenopausal symptoms, the effects of Lifenol on ovariectomy-induced osteoporosis, hyperlipidemia, body weight increase, and hot flash were investigated in rats. Methods: Female Sprague-Dawley rats were ovariectomized and subjected to a daily scheduled exercise training (15 min at 15 m/min) or treated with HE (30 or 100 mg/kg, oral) or 17 β -estradiol (100  μ g/kg, intraperitoneal) for 12 weeks...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29615318/effect-of-vitamin-d-supplementation-on-anthropometric-indices-among-overweight-and-obese-women-a-double-blind-randomized-controlled-clinical-trial
#16
Sajjad Roosta, Mina Kharadmand, Farshad Teymoori, Mehdi Birjandi, Ahmad Adine, Ebrahim Falahi
AIMS: The aim of this study was to investigate effect of vitamin D supplementation on anthropometric indices among women with overweight and obesity. METHODS: This double blind randomize clinical trial was conducted on 66 overweight and obese women. Those in intervention group received oral supplement of vitamin D 50,000 IU (1250 mcg) per 25 day and in control group participants received placebo for 3 months. Anthropometric indices were measured before and after 3 months intervention...
March 27, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29615306/structural-equation-modeling-to-explore-patient-to-staff-ratios-as-an-explanatory-factor-for-variation-in-dialysis-facility-outcomes
#17
Rosa K Hand, Jeffrey M Albert, Ashwini R Sehgal
OBJECTIVE: Patient to staff ratios vary based on facility characteristics, and therefore have been proposed as an explanatory factor for the variation in dialysis facility outcomes. This analysis tested that hypothesis. DESIGN AND METHODS: Observational study using Dialysis Facility Report data. Reported staff numbers from the Annual Facility Survey were converted to full time equivalents (FTE). Subsequently, ratios were created for patients per FTE registered dietitian (RD), social worker, nurse, and patient care technician...
March 31, 2018: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/29614569/-relationship-between-continuous-renal-replacement-therapy-and-hypophosphatemia-in-critically-ill-children
#18
T Sun, Y Q Ren, F Wang, H J Miao, Y J Shan, C X Wang, Y C Zhang
Objective: To investigate the incidence and prognosis of hypophosphatemia in critically ill children treated with continuous blood purification (CBP). Methods: The medical records of the critically ill patients, who were treated with CBP, admitted to pediatric intensive care unit (PICU) of Shanghai Children's Hospital from May 2014 to April 2017 were retrospectively analyzed. The serum phosphorus levels were tested before CBP, at 48-72 h during CBP, at the end of CBP and on the next day after CBP finished. Phosphorus supplement was given to the children with severe hypophosphatemia...
April 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29610557/dietary-intake-of-inorganic-phosphorus-has-a-stronger-influence-on-vascular-endothelium-function-than-organic-phosphorus
#19
Hiromi Kawamura, Sarasa Tanaka, Yuri Ota, Sumire Endo, Mariko Tani, Midori Ishitani, Motoyoshi Sakaue, Mikiko Ito
Phosphorus management through dietetic therapy is vital for the prevention of cardiovascular disease in chronic kidney disease patients. There are two main sources of phosphorus in the diet, organic phosphorus from protein and inorganic phosphorus from food additives. The adverse effects of high phosphorus intake on vascular-endothelium function have been reported; however, the differences in the effects of organic phosphorus versus inorganic phosphorus are not clear. In this study, we examined an acute effect of these high phosphorus meals intake on vascular-endothelium function...
March 2018: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/29609869/bone-status-and-adipokine-levels-in-children-on-vegetarian-and-omnivorous-diets
#20
Jadwiga Ambroszkiewicz, Magdalena Chełchowska, Katarzyna Szamotulska, Grażyna Rowicka, Witold Klemarczyk, Małgorzata Strucińska, Joanna Gajewska
BACKGROUND & AIMS: Measurements of bone mineral density (BMD) reflect bone status but not the dynamics of bone turnover. Biochemical markers, which show global skeletal activity, were validated for the assessment of bone formation and resorption processes. Adipokines also play a significant role in the regulation of bone metabolism. OBJECTIVE: To assess body composition, bone mineral density, bone turnover markers and adipokine levels in relation to vegetarian and omnivorous diets...
March 23, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
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