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https://www.readbyqxmd.com/read/29054741/virucidal-efficacy-of-food-additive-grade-calcium-hydroxide-against-surrogate-of-human-norovirus
#1
Natthanan Sangsriratanakul, Chiharu Toyofuku, Mayuko Suzuki, Miyuki Komura, Masashi Yamada, Md Shahin Alam, Sakchai Ruenphet, Dany Shoham, Kouji Sakai, Kazuaki Takehara
An alkaline agent, namely, food additive grade calcium hydroxide (FdCa(OH)2) in the solution, powder and suspension forms was evaluated as a virucidal agent, using a murine norovirus (MNV) as the surrogate for human norovirus. The main constituent of FdCa(OH)2 is Ca(OH)2, which has pH 13 in 0.17% solution. The results showed that 0.17% FdCa(OH)2 solution could inactivate MNV within 30sec even in the presence of organic materials (5% fetal bovine serum (FBS)). In a contaminated surface experiment, MNV with 5% FBS was inoculated on rayon sheets, and the result showed FdCa(OH)2 solution could markedly reduce virus titer within 1min...
October 17, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/29054385/functionalized-calcium-carbonate-microparticles-for-the-delivery-of-proteins
#2
R Roth, J Schoelkopf, J Huwyler, M Puchkov
The recently introduced functionalized calcium carbonate (FCC), a porous microparticle with a nano-structured, lamellar surface, shows promising properties in the field of oral drug delivery. In this work, FCC was loaded with biomolecules e.g. lysozyme (Lys) and bovine serum albumin (BSA) in order to investigate its suitability to deliver protein based drugs. Loading efficiency for our model proteins was >90%and enzyme activity was preserved as demonstrated by Michaelis-Menten enzyme kinetic experiments...
October 17, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29051397/in-situ-preservation-of-the-partathyroid-glands-in-total-thyroidectomy-a-propensity-score-matched-analysis
#3
Vincenzo Ambrogi, Erina Alushi, Antonio Montemurro, Arvin Dibra, Mario Stefani, Filadelfo Coniglione, Francesco Rulli
AIM: Severe hypocalcemia due to parathyroid gland damage may be a serious complication after thyroidectomy. In order to save parathyroid integrity we developed a no-touch parathyroid (NTP) thyroidectomy technique. METHODS: We performed a total extracapsular thyroidectomy with NTP technique in consecutive 50 cases of benign goiter between July 2014 and June 2015. Parathyroid glands were firstly indentified, then they were separated from the thyroid avoiding manipulation or trauma and preserving their vascularization...
2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29051042/bone-disease-in-primary-hyperparathyroidism
#4
Polyzois Makras, Athanasios D Anastasilakis
Primary hyperparathyroidism (PHPT) is a disease of high bone turnover, decreased bone mineral density (BMD) especially at cortical sites, and increased risk of fractures at all skeletal sites. Early diagnosis during the last decades resulted in milder forms of bone involvement. New methods of imaging and validation such as high resolution peripheral quantitative computed tomography and trabecular bone score provide evidence of disturbed bone microarchitecture and explain further the increased risk of fractures at both cortical and trabecular skeletal sites...
October 16, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29050431/a-study-on-the-sternum-growth-and-mineralization-kinetic-of-meat-duck-from-35-to-63-days-of-age
#5
H Y Zhang, H Liao, Q F Zeng, J P Wang, X M Ding, S P Bai, K Y Zhang
The sternum as an important part of the skeleton and not only provides a crucial attachment site for the pectoral muscles and protects internal organs such as the heart and lungs for meat duck, but may also be considered as the primary ventilator in the avian respiratory system. Therefore, this study focuses on the sternum growth and mineralization kinetics of ducks from 35 d to 63 d of age. A total of 72 one-d-old males and 72 females were chosen and fed with the same diet until the age of 9 weeks. The sternum and serum were harvested at 35 d, 42 d, 49 d, 56d, and 63 d of feeding...
September 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/29050147/-association-of-vitamin-d-receptor-gene-polymorphisms-with-idiopathic-hypoparathyroidism-phenotypes
#6
T T Quan, M Nie, Y P Li, Y Jiang, M Li, W B Xia, X W Meng, X P Xing, O Wang
Objective: To explore the association of vitamin D receptor (VDR) gene polymorphisms with idiopathic hypoparathyroidism (IHP). Methods: Two hundred and three patients with IHP and 209 healthy age- and sex-matched subjects were recruited at Peking Union Medical College Hospital between December 1987 and December 2015 as case group and control group, respectively. The VDR gene polymorphisms including rs739837, rs3847987 and rs2228570 were analyzed by Sequenom Mass Array. The frequency of different genotypes and alleles was detected, then their association with pathogenesis of IHP was analyzed...
September 26, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29049166/safety-of-potassium-bearing-citrate-in-patients-with-renal-transplantation-a-case-report
#7
Lin Wang, Yinglin Cui, Jianwei Zhang, Qinsheng Zhang
RATIONALE: Urinary lithiasis is one of severe postoperative complications in patients undergoing renal transplantation, possibly leading to anuria, urinary infection, or even acute renal failure. Potassium sodium hydrogen citrate (PSHC), a potassium-bearing citrate, is commonly prescribed to prevent stone formation. PATIENT CONCERNS: A 25-year-old man (patient 1) and a 31-year-old man (patient 2) receiving renal transplantation for end-stage renal disease (ESRD) were enrolled in this study...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29049040/the-relationship-between-nutritional-risks-and-cancer-related-fatigue-in-patients-with-colorectal-cancer-fast-track-surgery
#8
Jian-Ning Wei, Shu-Xia Li
BACKGROUND: Measurement of cancer-related fatigue and nutrition in the same colorectal cancer patient group using fast-track surgery has never been examined previously. The association between fatigue and nutritional status in the same patient group is thus worthwhile to be investigated. OBJECTIVE: The aim of this study was to evaluate the relationship between fatigue and nutrition risk factors in colorectal cancer patients with fast-track surgery. METHODS: This is a single-arm, observational study...
October 18, 2017: Cancer Nursing
https://www.readbyqxmd.com/read/29044930/effect-of-incident-nocturnal-home-hemodialysis-versus-incident-continuous-ambulatory-peritoneal-dialysis-on-employment-rate-clinical-and-laboratory-outcomes-a-1-year-retrospective-observation-study
#9
John Wing Li, Joseph Ho Sing Wong, Wai Leung Chak, Ka Foon Chau
INTRODUCTION: While studies demonstrated favorable outcomes of nocturnal home hemodialysis (NHHD), direct comparison on employment rate, clinical and laboratory outcomes between the NHHD and continuous ambulatory peritoneal dialysis (CAPD) had not been previously performed. METHODS: A 1-year retrospective observation study was performed in 20 incidents alternate night NHHD and 81 incident CAPD patients of Chinese ethnicity, who were sex, diabetic status, and Charlson comorbidity index matched, but not age due to our center's age limit for NHHD enrollment...
October 18, 2017: Hemodialysis International
https://www.readbyqxmd.com/read/29043208/phosphaturic-mesenchymal-tumor-pmt-exceptionally-rare-disease-yet-crucial-not-to-miss
#10
Amir Ghorbani-Aghbolaghi, Morgan Angus Darrow, Tao Wang
Phosphaturic mesenchymal tumors (PMTs) are very rare tumors which are frequently associated with Tumor Induced Osteomalacia (TIO), a paraneoplastic syndrome that manifests as renal phosphate wasting. The tumor cells produce a peptide hormone-like substance known as fibroblast growth factor 23 (FGF23), a physiologic regulator of phosphate levels. FGF23 decreases proximal tubule reabsorption of phosphates and inhibits 1-α-hydroxylase, which reduces levels of 1-α, 25-dihydroxyvitamine D3. Thus, overexpression of FGF23 by the tumor cells leads to increased excretion of phosphate in the urine, mobilization of calcium and phosphate from bones, and the reduction of osteoblastic activity, ultimately resulting in widespread osteomalacia...
July 2017: Autopsy & case reports
https://www.readbyqxmd.com/read/29042943/suxiao-jiuxin-pill-protects-cardiomyocytes-against-mitochondrial-injury-and-alters-gene-expression-during-ischemic-injury
#11
Xiaofen Ruan, Tiejun Chen, Xiaolong Wang, Yiping Li
Suxiao Jiuxin Pill (SX), a traditional Chinese medicine compound consisting primarily of tetramethylpyrazine and borneol, has been reported to protect against ischemic heart disease. However, the effects of SX on mitochondrial injury and gene expression in various signaling pathways are unclear. The aim of the present study was to investigate the effects of SX on mitochondrial injury and to screen the expression of genes potentially altered by SX using a cell culture model of ischemic injury. Simulated ischemia was established by culturing HL-1 cardiomyocytes in Dulbecco's modified Eagle medium without glucose or serum in a hypoxic chamber containing 95% N2 and 5% CO2 for 24 h...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042790/evaluation-of-vitamin-d-levels-in-relation-to-coronary-ct-angiographic-findings-in-an-iranian-population
#12
Maryam Moradi, Ali Foroutanfar
BACKGROUND: Vitamin D deficiency, as a predisposing factor for coronary artery disease (CAD), is a subject of increasing interest. However, its role as a risk factor has not been proven. This study aimed to investigate the relationship between serum vitamin D levels and CAD. MATERIALS AND METHODS: Using a cross-sectional design, 180 patients who were candidates for coronary computed tomography angiography (CCTA) were selected. Serum levels of vitamin D were measured and compared with the results of CCTA (including calcium score, and presence and severity of coronary artery involvement due to atherosclerotic plaques)...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/29042438/the-serum-protein-renalase-reduces-injury-in-experimental-pancreatitis
#13
Thomas R Kolodecik, Anamika M Reed, Kimie Date, Christine Shugrue, Vikhil Patel, Shang-Lin Chung, Gary V Desir, Fred S Gorelick
Acute pancreatitis is a disease associated with inflammation and tissue damage. One protein that protects against acute injury, including ischemic injury to both the kidney and heart, renalase, which is secreted into the blood by the kidney and other tissues. However, whether renalase reduces acute injury associated with pancreatitis is unknown. Here, we used both in vitro and in vivo murine models of acute pancreatitis to study renalase effects on this condition. In isolated pancreatic lobules, pretreatment with recombinant human renalase (rRNLS) blocked zymogen activation caused by cerulein, carbachol, and a bile acid...
October 17, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29039523/analysis-of-men1-c-482g-a-p-gly161asp-mutation-in-a-pedigree-with-familial-multiple-endocrine-neoplasia-type-1
#14
Yuanyuan Luo, Yongxiang Sun, Xiaofan Zhu, Xialian Li
Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterized by the development of neuroendocrine tumors, which in turn are caused by mutations in the MEN1 gene. In the present study, a case of a 46‑year‑old woman who was clinically diagnosed with MEN1 based on the presence of prolactinoma and bilateral parathyroid adenoma was reported. The patient's serum prolactin (PRL) levels were successfully controlled via bromocriptine therapy, and the serum levels of calcium and intact parathyroid hormone (PTH) reduced one day following parathyroidectomy...
October 10, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29039485/calcium-dobesilate-may-alleviate-diabetes%C3%A2-induced-endothelial-dysfunction-and-inflammation
#15
Yijun Zhou, Jiangzi Yuan, Chaojun Qi, Xinghua Shao, Shan Mou, Zhaohui Ni
Diabetic kidney disease (DKD) is a leading cause of end‑stage renal disease. However, the pathogenesis of DKD remains unclear, and no effective treatments for the disease are available. Thus, there is an urgent need to elucidate the pathogenic mechanisms of DKD and to develop more effective therapies for this disease. Human umbilical vein endothelial cells (HUVECs) were cultured using different D‑glucose concentrations to determine the effect of high glucose (HG) on the cells. Alternatively, HUVECs were incubated with 100 µmol/l calcium dobesilate (CaD) to detect its effects...
October 9, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29038882/etelcalcetide-a-novel-calcimimetic-prevents-vascular-calcification-in-a-rat-model-of-renal-insufficiency-with-secondary-hyperparathyroidism
#16
Longchuan Yu, James E Tomlinson, Shawn T Alexander, Kelly Hensley, Chun-Ya Han, Denise Dwyer, Marina Stolina, Charles Dean, William G Goodman, William G Richards, Xiaodong Li
Etelcalcetide, a novel peptide agonist of the calcium-sensing receptor, prevents vascular calcification in a rat model of renal insufficiency with secondary hyperparathyroidism. Vascular calcification occurs frequently in patients with chronic kidney disease (CKD) and is a consequence of impaired mineral homeostasis and secondary hyperparathyroidism (SHPT). Etelcalcetide substantially lowers parathyroid hormone (PTH) and fibroblast growth factor-23 (FGF23) levels in SHPT patients on hemodialysis. This study compared the effects of etelcalcetide and paricalcitol on vascular calcification in rats with adenine-induced CKD and SHPT...
October 16, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/29038673/thiazides-and-osteoporotic-spinal-fractures-a-suspected-linkage-investigated-by-means-of-a-two-center-case-control-study
#17
Renato De Vecchis, Carmelina Ariano, Giuseppina Di Biase, Michel Noutsias
BACKGROUND: An alleged association of chronic use of thiazide diuretics with an increased risk of bone fragility fractures has been highlighted by a relatively recent prospective cohort study. However, the concept that thiazides exert a beneficial effect on osteoporosis is still a predominant view. This effect would be mediated by the decrease in renal clearance of calcium ions, a pharmacological feature recognized for a long time now to this class of drugs, as opposed to the increase in calcium urinary excretion attributed instead to loop diuretics, i...
November 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29038394/factors-associated-with-lumbar-and-femoral-bone-mineral-density-in-kidney-transplants-candidates
#18
Mohammad Aghighi, Mitra Mahdavi Mazdeh, Mohsen Nafar, Vahid Rakhshan
INTRODUCTION: Data on risk factors associated with low bone mineral density are limited in patients with end-stage renal disease. This study evaluated the factors deemed associated with lumbar and femoral Z and T scores. MATERIALS AND METHODS: Clinical and demographic data of 98 patients waiting for kidney transplantation were collected, as well as lumbar and femoral bone densitometries, before transplantation. Osteoporosis and osteopenia and factors associated with bone mineral density were assessed...
October 2017: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/29038020/the-ca-2-camkk2-axis-mediates-the-telbivudine-induces-upregulation-of-creatine-kinase-implications-for-mechanism-of-antiviral-nucleoside-analogs-side-effect
#19
Long Jianfei, Wang Min, Ma Chunlai, Chen Bicui, Zhang Jiming, Wang Bin
Telbivudine (LdT), a widely prescribed anti-hepatitis B virus (HBV) drug for the treatment of chronic Hepatitis B (CHB), causes adverse reactions ranging from creatine kinase (CK) elevation to myopathy. The purpose of this study was to explore the mechanism(s) of LdT induced CK elevation. The effects of LdT on mitochondrial morphology and proteins (TK2 and β-actin), oxidative stress, intracellular Ca(2+) levels, Ca(2+)-related signaling pathway (CaMKK2/AMPK), and Ca(2+)-related biomarkers such as superoxide dismutase (SOD) and malondialdehyde (MDA) were assessed in human skeletal muscle cells (HSKMCs)...
October 13, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29037217/subtype-specific-differentiation-of-cardiac-pacemaker-cell-clusters-from-human-induced-pluripotent-stem-cells
#20
Patrick A Schweizer, Fabrice F Darche, Nina D Ullrich, Pascal Geschwill, Boris Greber, Rasmus Rivinius, Claudia Seyler, Karin Müller-Decker, Andreas Draguhn, Jochen Utikal, Michael Koenen, Hugo A Katus, Dierk Thomas
BACKGROUND: Human induced pluripotent stem cells (hiPSC) harbor the potential to differentiate into diverse cardiac cell types. Previous experimental efforts were primarily directed at the generation of hiPSC-derived cells with ventricular cardiomyocyte characteristics. Aiming at a straightforward approach for pacemaker cell modeling and replacement, we sought to selectively differentiate cells with nodal-type properties. METHODS: hiPSC were differentiated into spontaneously beating clusters by co-culturing with visceral endoderm-like cells in a serum-free medium...
October 16, 2017: Stem Cell Research & Therapy
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