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Kenji Yanoh, Yoshiaki Norimatsu, Satoru Munakata, Toshiya Yamamoto, Yutaka Nakamura, Tetsuya Murata, Tadao K Kobayashi, Yasuo Hirai
OBJECTIVE: To evaluate the sensitivity and specificity of the BD SurePath™ liquid-based Papanicolaou test for assessing the cytology of intrauterine endometrial samples according to newly devised cytological diagnostic criteria and a novel descriptive reporting format. MATERIALS AND METHODS: One hundred and twenty-two endometrial samples were analyzed. All samples were obtained directly from the intrauterine cavity using the Uterobrush or Honest Super Brush. The samples used for the histological examination and cytological tests were collected simultaneously...
2014: Acta Cytologica
Yoshiaki Norimatsu, Shingo Sakamoto, Hiroyuki Ohsaki, Satoru Ozaki, Toshiro Yokoyama, Keiko Shimizu, Kenji Yanoh, Minoru Akiyama, Masamichi Bamba, Tadao K Kobayashi
We compared the cytoarchitectural features used for the cytologic diagnosis of endometrial adenocarcinoma (EC) using ThinPrep® (TPS = ThinPrep Sample) and BD SurePath™ (SPS = SurePath Sample) preparations. In 20 patients, a direct endometrial sample using the Uterobrush was obtained. Nineteen cases of EA and one case of carcinosarcoma were studied. TPS and SPS were performed according to the manufacturer's recommendations. Moreover, after the TPS preparation, the residual material was also used to prepare an SPS sample (TP-SPS = ThinPrep-Surepath sample)...
August 2013: Diagnostic Cytopathology
Suzana Katalenić Simon, Ines Krivak Bolanca, Karmela Sentija, Gojko Zovko, Mario Podgajski, Josip Valetić, Anita Skrtić
Clear cell carcinoma is a rare form of endometrial carcinoma inline type II estrogen-independent. It accounts for only 1% to 5.5% of all endometrial carcinomas. It is usually detected in postmenopausal women, who are older than those with endometrioid carcinoma. Clear cell carcinoma may exhibit solid, papillary, tubular and cystic patterns. The malignant cells are characterized by a moderate amount of clear or foamy cytoplasm; however, its recognition as a clear cell type of cancer cytologically is not often possible...
September 2011: Acta Medica Croatica: C̆asopis Hravatske Akademije Medicinskih Znanosti
C Iavazzo, G Vorgias, G Mastorakos, G Stefanatou, A Panoussi, A Alexiadou, S Plyta, C Lekka, N Kalinoglou, V Dertimas, T Akrivos, S Fotiou
BACKGROUND: Endometrial brush cytology is a widely accepted method for the detection of endometrial lesions. The aim of this study was to evaluate the role of cytological sampling using Uterobrush in the screening of endometrial pathology. PATIENTS AND METHODS: This is a prospective double-blind study evaluating the efficacy of the Uterobrush method (Cooper Surgical, Trumbull, USA) in the detection of endometrial abnormalities. Endometrial cytology was performed during the period January 2009 to April 2010 in all symptomatic patients that underwent dilatation and curettage...
October 2011: Anticancer Research
Y Norimatsu, H Kouda, T K Kobayashi, K Shimizu, K Yanoh, C Tsukayama, Y Miyake, E Ohno
OBJECTIVE: The purpose of this study was to examine the utility of SurePath-liquid-based cytology (LBC) compared to conventional cytological preparations (CCP) in the identification of endometrial carcinoma. METHODS: During a 13-month period, direct endometrial samples were collected from 120 patients using the Uterobrush. The material comprised 30 cases each of endometrial carcinoma, proliferative endometrium, secretory endometrium and atrophic endometrium. The following points were investigated:(i) the frequency of cell clumps in endometrial carcinoma; (ii) the area of cell nuclei; (iii) overlapping nuclei...
December 2009: Cytopathology: Official Journal of the British Society for Clinical Cytology
Yoshiaki Norimatsu, Motoyuki Miyamoto, Tadao K Kobayashi, Takuya Moriya, Keiko Shimizu, Kenji Yanoh, Choutatsu Tsukayama, Yasuyuki Miyake, Eiji Ohno
BACKGROUND: For the current report, the authors examined the characteristic features of morphology and molecular biology of phosphatase and tensin homolog (PTEN), beta-catenin, and p53 immunocytochemistry in endometrial carcinoma by using thin-layer cytologic preparations. METHODS: During a 6-month period, 120 endometrial samples were collected directly by using the Uterobrush, and thin-layer specimens were prepared. Immunocytochemical expression levels of PTEN, beta-catenin, and p53 were investigated by using 40 specimens of endometrial carcinoma (EC), and 30 specimens each of proliferative endometrium, secretory endometrium, and atrophic endometrium...
June 25, 2008: Cancer
Yoshiaki Norimatsu, Tomoyuki Miyamoto, Tadao K Kobayashi, Tomohiro Oda, Takuya Moriya, Kenji Yanoh, Yasuyuki Miyake, Eiji Ohno
This article focuses on the characteristic features of morphology and molecular biology of PTEN, beta-catenin, and p53 immunocytochemistry in normal endometrium (proliferative, secretory, and atrophic) and endometrial glandular and stromal breakdown (EGBD) using thin-layer specimens. During a 6-month period, 120 endometrial samples were collected directly using the Uterobrush and a thin-layer specimen was prepared. Immunocytochemical expression of PTEN, beta-catenin, and p53 were investigated using 30 cases each of proliferative endometrium (PE), secretory endometrium (SE), atrophic endometrium (AE), and EGBD...
April 2008: Diagnostic Cytopathology
Yoshiaki Norimatsu, Hiromi Kouda, Tadao K Kobayashi, Takuya Moriya, Kenji Yanoh, Choutatsu Tsukayama, Yasuyuki Miyake, Eiji Ohno
The purpose of the current study was to examine the use of thin-layer cytologic (TLC) preparation compared to conventional cytologic preparation (CCP) in the normal endometrium (proliferative, secretory, atrophic) and endometrial glandular and stromal breakdown (EGBD). During a 6-month period, we compiled 158 cases by collecting a direct endometrial sample using the Uterobrush. The material comprised 40 cases of proliferative endometrium, 42 cases of secretory endometrium, 46 cases of atrophic endometrium, and 30 cases of EGBD...
April 2008: Annals of Diagnostic Pathology
Akemi Fujihara, Yoshiaki Norimatsu, Tadao K Kobayashi, Osamu Iwanari, Saburou Nagaoka
The aim of this study was to evaluate the efficacy of endometrial cytology using the Uterobrush in the collection of samples for the diagnosis of endometrial lesions. The preparation technique for endometrial brushing specimens was also demonstrated. In their earlier study, the authors described the cyto-architectural criteria that appear to be more useful for the cytological assessment of endometrial lesions. Therefore, for the application of the diagnostic criteria, endometrial cytological sampling will become more important...
July 2006: Diagnostic Cytopathology
Anna Belowska
During the past few decades, a variety of diagnostic methods for endometrium direct sampling have been developed. One of these new techniques is endometrial brush biopsy (uterobrush). The principal aim of uterobrush is early detection of endometrial carcinomas and their precursors, but it may be also used to follow up the patients undergoing hormone replacement therapy (HRT). So far, there are only few clinical reports evaluating uterobrush as a technique useful in monitoring endometrial cytology during HRT...
June 2004: Ginekologia Polska
P.J. Klemi, K.A. Alanen, T. Salmi
Endometrial brush samples were taken from 1042 symptomatic hospital patients using Uterobrush(R), and the results were compared either to the histology of the endometrium obtained with dilatation and curettage (n = 313) or the patients' follow-up (n = 729). Only one cancer (100%) among patients </= 51 years of age (n = 677) was found by this method. Of the 12 cancers among patients> 51 years of age (n = 365), 11 (91.7%) were detected by Papanicolaou classes III-V. One cancer was missed, whereas no false positive results were found...
May 1995: International Journal of Gynecological Cancer
S Sato, N Yaegashi, K Shikano, S Hayakawa, A Yajima
OBJECTIVE: To compare two endometrial cytologic sampling devices, the Uterobrush and Endocyte, for their clinical applicability. STUDY DESIGN: Specimen collection and comparison in 60 women. RESULTS: Collection of specimens with both devices succeeded in 100% of cases and was practically painless. The cells' appearance with the Endocyte tended to be dense. Nevertheless, the amount of cells collected with both devices was adequate for diagnosis except in a few cases...
September 1996: Acta Cytologica
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