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Brush samples ,endometrial carcinoma

Jiang Du, Yaling Li, Shulan Lv, Qing Wang, Chao Sun, Xin Dong, Ming He, Qurat Ulain, Yongxing Yuan, Xiaoqian Tuo, Nasra Batchu, Qing Song, Qiling Li
PURPOSE: Endometrial carcinoma is the most common gynecologic malignancy in both developed and some developing countries. Unlike cervical cancer, for which there is routine screening, only patients symptomatic for endometrial carcinoma typically seek medical help for its diagnosis and treatment. Dilatation and curettage (D&C) has been the standard procedure for evaluating suspicious endometrial lesions. The discomfort and injury caused by the D&C procedure, however, restrict its use as a screening method for early diagnosis of endometrial lesions...
August 11, 2016: Journal of Cancer Research and Clinical Oncology
Nalini Gupta, Vikrant Bhar, Pranab Dey, Arvind Rajwanshi, Vanita Suri
Cervical sample is routinely taken to identify squamous dysplastic lesions of the cervix. Glandular lesions are far less commonly reported on cervical samples. The most common glandular lesion reported on cervical smear is endocervical adenocarcinoma, followed by endometrial adenocarcinoma. Direct sampling by Cervex brush is possible even in endometrial adenocarcinoma, if the tumor directly involves lower uterine segment/endocervical canal. Metastases to cervix are rare but have occasionally been reported in previous reports...
July 2014: Journal of Cytology
Ibrahim A Abdelazim, Khaled M Abdelrazak, Assem A M Elbiaa, Mohamed Al-Kadi, Amr H Yehia
OBJECTIVES: To compare the diagnostic accuracy of brush endometrial sampling with conventional dilatation and curettage in women with abnormal uterine bleeding. PATIENTS AND METHODS: Two hundred and twenty (220) women with abnormal uterine bleeding were included in this comparative study; endometrial sampling was done before cervical dilatation using Tao Bruch followed by conventional dilatation and curettage (D&C). The histopathology report of the Tao Bruch samples was compared with that of the D&C samples and the D&C results were considered as the gold standard...
May 2015: Archives of Gynecology and Obstetrics
Nicolas Wentzensen, Jamie N Bakkum-Gamez, J Keith Killian, Joshua Sampson, Richard Guido, Andrew Glass, Lisa Adams, Patricia Luhn, Louise A Brinton, Brenda Rush, Lori d'Ambrosio, Munira Gunja, Hannah P Yang, Montserrat Garcia-Closas, James V Lacey, Jolanta Lissowska, Karl Podratz, Paul Meltzer, Viji Shridhar, Mark E Sherman
The prognosis of endometrial cancer is strongly associated with stage at diagnosis, suggesting that early detection may reduce mortality. Women who are diagnosed with endometrial carcinoma often have a lengthy history of vaginal bleeding, which offers an opportunity for early diagnosis and curative treatment. We performed DNA methylation profiling on population-based endometrial cancers to identify early detection biomarkers and replicated top candidates in two independent studies. We compared DNA methylation values of 1,500 probes representing 807 genes in 148 population-based endometrial carcinoma samples and 23 benign endometrial tissues...
October 15, 2014: International Journal of Cancer. Journal International du Cancer
Ayman M Metwally, Lobna A Refaat, HebatAllah Shaaban, Somaia Megm, Mohamed Emara, Amany A Tohamy, Eman Abou Sinna, Hussein Khaled
PURPOSE: The objective of our study was to determine the relevance of cyclins A and E overexpression in endometrial carcinogenesis in hormone receptor-positive breast cancer patients under tamoxifen therapy. EXPERIMENTAL DESIGN: We assessed expression of cyclins A and E in Endometrial cytology samples collected from 36 ER and PR positive breast cancer patients; under tamoxifen treatment by using the Tao-brush non-invasive brushing cytology technique. Cyclins were detected in the collected samples by means of immuno-cytochemistry...
December 2013: Journal of the Egyptian National Cancer Institute
C Manini, P L Montironi, A Magistris, D Stramignoni
INTRODUCTION: The efficacy of direct endometrial sampling by brushing in the collection of adequate and representative material is evaluated. METHODS: From January 1 2008 to October 31 2009, 195 women (age 29-82, mean 56, 113 postmenopausal), underwent endometrial brushing with Endoflower. All samplings were performed in an outpatient setting. 137 patients had abnormal uterine bleeding (70 postmenopausal), 25 had asymptomatic endometrial thickening (> 4 mm), 6 had atypical endometrial cells on pap-smear, 9 patients needed preoperative controls for uterine prolapse, 11 were treated with tamoxifen and 7 had other problems...
April 2010: Pathologica
C Remondi, F Sesti, E Bonanno, A Pietropolli, E Piccione
OBJECTIVE: The aim of this study was to compare liquid-based endometrial cytology with hysteroscopy and endometrial biopsy regarding its diagnostic accuracy in a series of postmenopausal women with abnormal uterine bleeding (AUB) or asymptomatic women with thickened endometrium assessed by transvaginal ultrasound as a screening procedure. METHODS:   Inclusion criteria were: menopausal status; the presence of AUB and/or thickened endometrium assessed by ultrasound (cut-off 4 mm); a normal Papanicolaou (Pap) smear; and no adnexal pathology at ultrasound...
December 2013: Cytopathology: Official Journal of the British Society for Clinical Cytology
Yoshiaki Norimatsu, Yumie Shigematsu, Shingo Sakamoto, Hiroyuki Ohsaki, Kenji Yanoh, Namiki Kawanishi, Tadao K Kobayashi
This study was to clarify the nuclear features of "condensed clusters of stromal cells (EGBD-stromal cells)" and "metaplastic clumps with irregular protrusions (EGBD-metaplastic cells)" which may be recognized in endometrial glandular and stromal breakdown (EGBD) cases in liquid-based cytologic (LBC) preparations of endometrial brushings. The material consists of cytologic smears of 20 cases of proliferative endometrium (PE), 20 cases of EGBD, and 20 cases of endometrioid adenocarcinoma grade 1 (G1) for which histopathological diagnosis was obtained by endometrial curettage...
December 2012: Diagnostic Cytopathology
C Iavazzo, G Vorgias, G Mastorakos, G Stefanatou, A Panoussi, A Alexiadou, S Plyta, C Lekka, N Kalinoglou, V Dertimas, T Akrivos, S Fotiou
BACKGROUND: Endometrial brush cytology is a widely accepted method for the detection of endometrial lesions. The aim of this study was to evaluate the role of cytological sampling using Uterobrush in the screening of endometrial pathology. PATIENTS AND METHODS: This is a prospective double-blind study evaluating the efficacy of the Uterobrush method (Cooper Surgical, Trumbull, USA) in the detection of endometrial abnormalities. Endometrial cytology was performed during the period January 2009 to April 2010 in all symptomatic patients that underwent dilatation and curettage...
October 2011: Anticancer Research
E K J Risse, E Ouwerkerk-Noordam, M E Boon
OBJECTIVE: It was our aim to assess the usefulness of cytohistology in cervical thin layer brush samples with problems in the differential diagnosis of endometrial cells. STUDY DESIGN: This study reveals the cytological, cytohistological and immunohistochemistry findings of 8 cases suspicious of adenocarcinoma in situ (AIS)/adenocarcinoma (AC) in cervical liquid-based cytology (LBC) preparations that turned out to be normal endometrial cells. RESULTS: All 8 cervical LBCs featured endometrial and atypical endocervical-like columnar cells with frequent ragged 'feathered' edge appearance and rosette formations...
2011: Acta Cytologica
Elle K J Risse, Elisabeth Ouwerkerk-Noordam, Elisabeth M Meijer-Marres, Mathilde E Boon
OBJECTIVE: To exploit cervical thin layer brush samples through cytohistology in cases with invasive carcinoma with application of antibodies. STUDY DESIGN: Fourteen cases from women with carcinoma diagnosed in 2006 were selected out of 29 invasive carcinomas. From these 14 cases liquid-based cervical cytology material was available to prepare cytohistology. Eight women had squamous cell carcinoma, 4 endocervical adenocarcinoma, 1 endometrial adenocarcinoma and 1 ovarian adenocarcinoma...
March 2010: Acta Cytologica
Junqi Qian, Deena Weber, Richard Cochran, Deloar Hossain, David G Bostwick
BACKGROUND: Endometrial cancer is the most common pelvic gynecological malignancy. The diagnosis of well-differentiated endometrial adenocarcinoma, atypical hyperplasia, and hyperplasia is often challenging. The authors sought to investigate the utility of chromosomal anomalies for the detection of endometrial hyperplasia and carcinoma using multitarget fluorescence in situ hybridization (FISH). METHODS: Samples were collected by endometrial Tao brush and processed by liquid-based cytological preparation protocol from consecutive cases to include 50 benign, 50 hyperplasia without atypia, 47 atypical hyperplasia, and 53 endometrial cancers...
April 25, 2010: Cancer Cytopathology
Etsuko Nakamura, Mayumi Iwakawa, Reiko Furuta, Tatsuya Ohno, Toyomi Satoh, Miyako Nakawatari, Ken-ichi Ishikawa, Kaori Imadome, Yuichi Michikawa, Tomoaki Tamaki, Shingo Kato, Tomoyuki Kitagawa, Takashi Imai
The number of new cervical adenocarcinoma (AD) cases has risen slowly, however, its histological similarity to other tumor types and the difficulty of identifying the site of the original tumor makes the diagnosis of cervical AD particularly challenging. We investigated a novel molecular biomarker for cervical AD through the integration of multiple methods of genomic analysis. Tumor samples in discovery set were obtained from 87 patients who underwent radiotherapy, including 31 cervical AD. Microarray analysis and quantitative polymerase chain reaction analysis were performed to screen a candidate diagnostic molecule for cervical AD, and its clinical significance was investigated by immunohistochemical analysis (IHC)...
June 2009: Cancer Biology & Therapy
Kristin K Zorn, Tomas Bonome, Lisa Gangi, Gadisetti V R Chandramouli, Christopher S Awtrey, Ginger J Gardner, J Carl Barrett, Jeff Boyd, Michael J Birrer
PURPOSE: The presence of similar histologic subtypes of epithelial ovarian and endometrial cancers has long been noted, although the relevance of this finding to pathogenesis and clinical management is unclear. Despite similar clinical characteristics, histologic subtypes of cancers of the ovary and endometrium are treated according to organ of origin. This study compares the gene expression profiles of analogous histologic subtypes of cancers of the ovary and endometrium using the same genomic platform to determine the similarities and differences between these tumors...
September 15, 2005: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Anna Belowska
During the past few decades, a variety of diagnostic methods for endometrium direct sampling have been developed. One of these new techniques is endometrial brush biopsy (uterobrush). The principal aim of uterobrush is early detection of endometrial carcinomas and their precursors, but it may be also used to follow up the patients undergoing hormone replacement therapy (HRT). So far, there are only few clinical reports evaluating uterobrush as a technique useful in monitoring endometrial cytology during HRT...
June 2004: Ginekologia Polska
Howard Her-Juing Wu, Bryan D Casto, Tarik M Elsheikh
OBJECTIVE: To describe 633 cases using the Tao Brush for endometrial biopsy (EBB) in an outpatient setting. STUDY DESIGN: Histologic follow-up specimens within six months of EBB in an outpatient setting were evaluated over a two-year period. Diagnosis by EBB relied mainly on histologic evaluation of hematoxylin and eosin-stained tissue sections and was complemented by additional cytologic smear examination in our laboratory. Diagnostic categories included the following: nondiagnostic (ND), benign endometrium (BE), hyperplasia without atypia (H), atypia (AT) and atypical hyperplasia (AH)/carcinoma (CA)...
January 2003: Journal of Reproductive Medicine
H H Wu, K E Harshbarger, H W Berner, T M Elsheikh
We examined 200 cases of endometrial brush biopsy (EBB) using the Tao brush and correlated findings with histologic findings from subsequent dilatation and curettage (D&C) or hysterectomy specimens. Diagnosis by EBB relied mainly on histologic evaluation of H&E-stained tissue sections and was complemented by additional cytologic smear examination. EBB correctly detected the following cases: endometrioid adenocarcinoma, 3; complex hyperplasia with atypia, 1; simple hyperplasia without atypia (SH), 2; and benign endometrium, 177...
September 2000: American Journal of Clinical Pathology
J A Maksem
Following successful hysterectomy-controlled trials, Tao brush endometrial cytology with liquid fixation was offered to clinicians for office use. This report recounts our first year's cytology and correlative histology outcomes. One hundred thirteen cases were accrued. Correlative tissue examinations comprising Pipelle (Prodimed, Neuilly-en-Thelle, France) biopsy, hysteroscopy and biopsy, dilatation and curettage, and hysterectomy were available at this institution for 59 cases. In 42 cases, cytology diagnoses could be compared to histology diagnoses...
March 2000: Diagnostic Cytopathology
J A Maksem, S S Lee, E B Roose, J A Carlson, D P Dornbier, B L Belsheim
Liquid-fixed Tao brush samples showing small quantities (less than 10%) of endometrial epithelial sheets with cancer-like nuclei that are admixed with benign endometrium raise a concern about false-positive cytology interpretations. This paper details 7 cases along with the outcomes of three prior papers that touch on the differential diagnosis of "small amounts of atypical epithelium with cancer-like nuclei." Liquid-fixed, cytocentrifuge-processed Tao brush endometrial samples from 7 women showing "small amounts of atypical epithelium with cancer-like nuclei" were followed up by hysterectomy...
December 1999: Diagnostic Cytopathology
J Kunz, R Rondez, C Yoshizaki, M Fivian, G Held, B Lind
Cervical smears of 554 outpatients of a hospital were examined using a blinded, split sample match pair protocol for which a conventional PAP-smear (CS) was first prepared with Cervex brush and the reminder of the sample was used for the thin-layer-preparation (TLP) according to the manual CytoRich System. The preparations of the two methods were compared with respect to quality and to sensitivity for atypias. In addition the HPV status was determined on the same cell suspension in cases with borderline changes (BLC) and dysplasias including carcinoma using the Hybrid Capture System...
October 21, 1998: Praxis
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