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Endometrial liquid-based cytology

Fumiko Yanaki, Yasuo Hirai, Azusa Hanada, Ken Ishitani, Hideo Matsui
OBJECTIVE: We evaluated the clinical performance of liquid-based endometrial cytology (SurePath™) for detecting endometrial malignancies by comparison with the performance of suction endometrial tissue biopsy. STUDY DESIGN: From November 2011 to May 2013, we consecutively collected 1,118 liquid-based endometrial cytology specimens and 674 suction endometrial tissue biopsy specimens. RESULTS: The rate of nonpositive final histology in nonpositive liquid-based endometrial cytology (98...
March 22, 2017: Acta Cytologica
Hyun Sil Yun, Sun Kyung Lee, Gun Yoon, Hwi Gon Kim, Dong Hyung Lee, Yong Jin Na, Ook Hwan Choi, Dong Hoon Shin, Yong Jung Song
Lymphoepithelioma-like carcinoma (LELC) of the uterine cervix is exceedingly uncommon. We herein report a rare case of cervical LELC. A 45-year-old woman was admitted to gynecology department with vaginal bleeding for one month. Liquid-based cytology revealed atypical endometrial cells, not otherwise specified on her cervix. On a hysteroscopy, an endocervical mass was identified and the pathologic result was consistent with poorly differentiated squamous cell carcinoma. Magnetic resonance imaging and positron emission tomography with 2-deoxy-2-[fluorine-18] fluoro-D-glucose integrated with computed tomography revealed a 3...
January 2017: Obstetrics & Gynecology Science
Georgios-Marios Makris, Abraham Pouliakis, Charalampos Siristatidis, Niki Margari, Emmanouil Terzakis, Nikolaos Koureas, Vasilios Pergialiotis, Nikolaos Papantoniou, Petros Karakitsos
BACKGROUND: This study aims to investigate the efficacy of an Artificial Neural Network based on Multi-Layer Perceptron (ANN-MPL) to discriminate between benign and malignant endometrial nuclei and lesions in cytological specimens. METHODS: We collected 416 histologically confirmed liquid-based cytological smears from 168 healthy patients, 152 patients with malignancy, 52 with hyperplasia without atypia, 20 with hyperplasia with atypia, and 24 patients with endometrial polyps...
March 2017: Diagnostic Cytopathology
Ke Ma, Xi Yang, Rui Chen, Jian Zhao, Ying Dong, Nai-Yi Zhang, Xiu-Hua Ma, Qin-Ping Liao
OBJECTIVE: The aim of this study was to investigate the diagnostic accuracy of liquid-based endometrial cytology in postmenopausal women, in comparison with histology. MATERIALS AND METHODS: There were 790 postmenopausal women scheduled for hysteroscopy enrolled in this study. After providing informed consent, all patients proceeded sequentially through endometrial cytology, hysteroscopy, and then dilatation and curettage (D&C). Cytology sampling was performed by brushing the uterus cavity using SAP-1 and the sample was prepared to liquid-based smear using SurePath technology...
December 2016: Taiwanese Journal of Obstetrics & Gynecology
Hiroyuki Kuramoto, Yoshiko Iwami, Naoko Sugimoto, Jun Miyagawa, Midori Banno, Manichi Iida
OBJECTIVE: To evaluate whether or not the liquid-based procedure (LBP) for endometrial cytology is as worthwhile for endometrial phasing as conventional slides. MATERIALS AND METHODS: The subjects were 81 women who underwent endometrial cytology and were defined as negative. The specimens obtained by either Endocyte® or Masubuchi aspiration tube® were processed first with the conventional procedure and then with LBP using TACAS™. RESULTS: (1) The number of subjects diagnosed by the conventional method as having proliferative, mid-, middle-secretory and late-secretory and atrophic phases was 40, 11, 10, 0 and 20, respectively...
2016: Acta Cytologica
P Gupta, N Gupta, P Dey
BACKGROUND: Exfoliated endometrial cells can be seen in cervical smears in association with a wide variety of conditions ranging from normal proliferative endometrium to endometrial malignancies. It is often difficult to differentiate between benign, atypical and malignant endometrial cells using cytomorphology alone. This study was conducted to evaluate if morphometric analysis of endometrial nuclei on liquid-based cervical samples could be of help in differentiating between these endometrial cells...
April 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
Hui Zhang, Jia Wen, Pi-Li Xu, Rui Chen, Xi Yang, Lian-Er Zhou, Ping Jiang, An-Xia Wan, Qin-Ping Liao
BACKGROUND: Liquid-based cytology (LBC) offers an alternative method to biopsy in screening endometrial cancer. Cell block (CB), prepared by collecting residual cytological specimen, represents a novel method to supplement the diagnosis of endometrial cytology. This study aimed to compare the specimen adequacy and diagnostic accuracy of LBC and CB in the diagnosis of endometrial lesions. METHODS: A total of 198 women with high risks of endometrial carcinoma (EC) from May 2014 to April 2015 were enrolled in this study...
June 20, 2016: Chinese Medical Journal
Y Norimatsu, T Yamaguchi, T Taira, H Abe, H Sakamoto, M Takenaka, K Yanoh, M Yoshinobu, S Irino, Y Hirai, T K Kobayashi
OBJECTIVE: The purpose of the present study was to evaluate the reproducibility of the cytological diagnosis of endometrial lesions by the Osaki Study Group (OSG) method of new cytological diagnostic criteria using BD SurePath(™) (SP)-liquid-based cytology (LBC). METHODS: This cytological classification using the OSG method consists of six categories: (i) normal endometrium (NE), (ii) endometrial glandular and stromal breakdown (EGBD), (iii) atypical endometrial cells, cannot exclude atypical endometrial hyperplasia or more (ATEC-A), (iv) adenocarcinoma including atypical endometrial hyperplasia or malignant tumour (Malignancy), (v) endometrial hyperplasia without atypia (EH) and (vi) atypical endometrial cells of undetermined significance (ATEC-US)...
December 2016: Cytopathology: Official Journal of the British Society for Clinical Cytology
Baneet Bansal, Parikshaa Gupta, Nalini Gupta, Arvind Rajwanshi, Vanita Suri
BACKGROUND: The sensitivity of cervical cytology for detection of glandular lesions is reported to be low. We conducted this study to assess the diagnostic accuracy of cervical Papanicolaou (Pap) smears for uterine glandular lesions and to compare the diagnostic utility of conventional and liquid-based cytology (LBC) smears for glandular lesions. MATERIALS AND METHODS: Archived histopathology records of all cases reported as endocervical and endometrial adenocarcinoma in the study period were identified and the available corresponding Pap smears (in preceding 1 year) were retrieved...
2016: CytoJournal
Nalini Gupta, John Crossley, Nick Dudding, John H F Smith
OBJECTIVE: The cytomorphological criteria of malignant endometrial lesions in cervical samples are less well described than those of cervical lesions. We wished to investigate if there were features in SurePath™ liquid-based cytology samples that would facilitate more accurate differentiation between benign and malignant endometrial cells. STUDY DESIGN: This was a two-phase study, with a review of all SurePath™ samples reported as endometrial adenocarcinoma (n = 42) evaluating 12 cytological features in the first phase...
2016: Acta Cytologica
Ron C Bowditch, Joanne M Clarke, Phillip J Baird, Merle L Greenberg
BACKGROUND: The trial results of BD FocalPoint™ GS computer assisted screening(FP) of BD SurePath(®) liquid based cervical cytology slides (SP) were published in Diagnostic Cytopathology in 2012.(1) METHOD: The FP-reviewed SP slides were compared to conventional cervical Pap smears (CON) in a split sample of 2198 routine specimens. In all 47 confirmed high grade (HG) cases, FP either selected fields of view (FOV) containing cells suspicious or diagnostic of HG (46/47), or prompted full screening of the slide (1/47) leading to detection of the HG lesion...
November 2015: Diagnostic Cytopathology
Jennifer M Roberts, Alyssa M Cornall, Vincent Lamaro, Sepehr N Tabrizi, Peter Russell
A 38-yr-old woman, with a previous history of low grade squamous intraepithelial lesion in the cervix, presented with heavy menstrual bleeding. At hysteroscopy, a fundal polyp was removed from the right cornu which displayed many glands lined by atypical, mitotically active epithelium with features characteristic of endocervical adenocarcinoma in situ (AIS) of intestinal subtype. Subsequent cervical liquid-based cytology and colposcopically directed biopsies revealed no causative lesion, but residual PreservCyt from the ThinPrep vial tested positive for high risk HPV type other than HPV 16 and 18...
May 2015: International Journal of Gynecological Pathology
Jia Wen, Rui Chen, Jian Zhao, Yin Dong, Xi Yang, Qin-Ping Liao
BACKGROUND: The aim of this study was to compare specimen adequacy of SAP-1 provided for cytology with that of dilation and curettage (D & C) or hysteroscopy for histology, and evaluate the accuracy of combining endometrium sampling by SAP-1 and liquid-based cytology using SurePath preparation for screening endometrial carcinoma and its precursor. METHODS: Endometrial specimens from women (n = 1514) with risk factors were obtained using an SAP-1 device for cytological analysis; histological samples were obtained from 375 of these women who underwent D & C or hysteroscopy...
March 5, 2015: Chinese Medical Journal
Nalini Gupta, Vikrant Bhar, Pranab Dey, Arvind Rajwanshi, Vanita Suri
Cervical sample is routinely taken to identify squamous dysplastic lesions of the cervix. Glandular lesions are far less commonly reported on cervical samples. The most common glandular lesion reported on cervical smear is endocervical adenocarcinoma, followed by endometrial adenocarcinoma. Direct sampling by Cervex brush is possible even in endometrial adenocarcinoma, if the tumor directly involves lower uterine segment/endocervical canal. Metastases to cervix are rare but have occasionally been reported in previous reports...
July 2014: Journal of Cytology
Alessia Di Lorito, Roberta Zappacosta, Serena Capanna, Daniela Mariapia Gatta, Sandra Rosini, Fernando Carlos Schmitt
OBJECTIVES: Endometrial cytology offers a reliable alternative to biopsy in endometrial cancer detection and it may be useful in obtaining material to study prognostic and predictive markers. Over the years, new sampling devices have been developed. Molecular alterations in endometrial cancers were previously described using formalin-fixed paraffin-embedded tissues with particular attention, in endometrioid carcinomas, to the PTEN-PI3K pathway. PTEN evaluation could be useful in endometrial carcinomas for selecting patients for target therapies...
2014: Acta Cytologica
Dimitrios Zygouris, Abraham Pouliakis, Niki Margari, Charalampos Chrelias, Emmanouil Terzakis, Nikolaos Koureas, Ioannis Panayiotides, Petros Karakitsos
OBJECTIVE: To investigate the potential of a computerized system for the discrimination of benign from malignant endometrial nuclei and lesions. STUDY DESIGN: A total of 228 histologically confirmed liquid-based cytological smears were collected: 117 within normal limits cases, 66 malignant cases, 37 hyperplasias without atypia, and 8 cases of hyperplasia with atypia. From each case we extracted nuclear morphometric features from about 100 nuclei using a custom image analysis system...
August 2014: Analytical and Quantitative Cytopathology and Histopathology
Kenji Yanoh, Yoshiaki Norimatsu, Satoru Munakata, Toshiya Yamamoto, Yutaka Nakamura, Tetsuya Murata, Tadao K Kobayashi, Yasuo Hirai
OBJECTIVE: To evaluate the sensitivity and specificity of the BD SurePath™ liquid-based Papanicolaou test for assessing the cytology of intrauterine endometrial samples according to newly devised cytological diagnostic criteria and a novel descriptive reporting format. MATERIALS AND METHODS: One hundred and twenty-two endometrial samples were analyzed. All samples were obtained directly from the intrauterine cavity using the Uterobrush or Honest Super Brush. The samples used for the histological examination and cytological tests were collected simultaneously...
2014: Acta Cytologica
M Fambrini, F Sorbi, G Sisti, R Cioni, I Turrini, G Taddei, S Guaschino
Endometrial carcinoma (EC) is the leading female genital tract malignancy in industrialized countries. It will become an important public health problem in the coming years in the USA and Europe, where its incidence is increasing, and next-generation interventions should include periodical screening in high-risk women. In this review, we discuss the importance to gynaecologists of detecting women at high risk and offering an adequate screening programme. Screening for EC is particularly challenging and there is currently no proven programme for the surveillance of women estimated to be at an increased risk of developing this form of cancer...
April 2014: Cytopathology: Official Journal of the British Society for Clinical Cytology
Abraham Pouliakis, Charalampia Margari, Niki Margari, Charalampos Chrelias, Dimitrios Zygouris, Christos Meristoudis, Ioannis Panayiotides, Petros Karakitsos
'The objective of this study is to investigate the potential of classification and regression trees (CARTs) in discriminating benign from malignant endometrial nuclei and lesions. The study was performed on 222 histologically confirmed liquid based cytological smears, specifically: 117 benign cases, 62 malignant cases and 43 hyperplasias with or without atypia. About 100 nuclei were measured from each case using an image analysis system; in total, we collected 22783 nuclei. The nuclei from 50% of the cases (the training set) were used to construct a CART model that was used for knowledge extraction...
July 2014: Diagnostic Cytopathology
Yoshiaki Norimatsu, Hiroyuki Ohsaki, Hiroshi Masuno, Akihiro Kagawa, Norihiro Teramoto, Tadao K Kobayashi
OBJECTIVE: The removal of blood components is necessary to improve the quality of the liquid-based cytology (LBC) preparations. In ThinPrep® (TP) samples a cell suspension in a methanol-based fixative undergoes a vacuum filtration method, whereas in SurePath™ (SP) samples a cell suspension in an ethanol-based fixative is processed through a density gradient centrifugation system prior to gravity deposition of the specimen onto a glass slide. We compared the cyto-architectural features for the cytologic diagnosis of endometrial adenocarcinoma using parallel TP and SP preparations in a previous publication...
2014: Acta Cytologica
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