Jintao Li, Haolin Ke, Xiangcheng Lei, Jiexin Zhang, Zhicheng Wen, Zhisheng Xiao, Huabin Chen, Juncheng Yao, Xuan Wang, Zhengnong Wei, Hongrui Zhang, Weilun Pan, Yan Shao, Yitao Zhao, Denghui Xie, Chun Zeng
Tendon-bone interface injuries pose a significant challenge in tissue regeneration, necessitating innovative approaches. Hydrogels with integrated supportive features and controlled release of therapeutic agents have emerged as promising candidates for the treatment of such injuries. In this study, we aimed to develop a temperature-sensitive composite hydrogel capable of providing sustained release of magnesium ions (Mg2+ ). We synthesized magnesium-Procyanidin coordinated metal polyphenol nanoparticles (Mg-PC) through a self-assembly process and integrated them into a two-component hydrogel...
June 2024: Bioactive Materials