keyword
MENU ▼
Read by QxMD icon Read
search

Interlukin 6

keyword
https://www.readbyqxmd.com/read/27901470/sinomenine-prevents-the-development-of-cardiomyopathy-in-diabetic-rats-by-inhibiting-inflammatory-responses-and-blocking-activation-of-nf-%C3%AE%C2%BAb
#1
Cheng Jiang, Yun-Long Tong, Dan Zhang, Li-Zhi Liu, Ju-Fei Wang
Diabetic cardiomyopathy is a severe complication of diabetes mellitus (DM). The goal of current work was to study the effects of sinomenine on streptozotocin-induced cardiomyopathy in rats. DM in rats was induced by intraperitoneal injection of streptozotocin. Cardiac function was evaluated by measuring left ventricle end-diastolic diameter, left ventricle end-systolic diameter and ejection fraction. Cardiac inflammation was evaluated by the degree of infiltration of T lymphocytes and the levels of pro-inflammatory cytokines...
November 30, 2016: General Physiology and Biophysics
https://www.readbyqxmd.com/read/27731803/effect-of-gabab-receptor-antagonists-cgp-35348-and-cgp-55845-on-serum-interleukin-6-and-18-concentrations-in-albino-mice-following-neonatal-hypoxia-ischemia-insult
#2
Quratulane Gillani, Muhammad Ali, Furhan Iqbal
Interleukin (IL) 6 and 18 plays an important role in inflammatory response following hypoxia ischemia encephalopathy (HIE). Present study was designed to demonstrate the effect of two GABAB receptor antagonists (CGP 35348 and 55845), respectively, on the serum IL6 and IL 18 concentrations in albino mice. Albino mice pups (of both genders) were subjected to Murine model of hypoxia-ischemia encephalopathy on postnatal day 10 (right common carotid artery was ligated followed by 8% hypoxia for 25 minutes). After neonatal brain damage and following weaning, mice were divided in three groups, in gender specific manner, and fed on normal rodent diet till they were 13 week old...
September 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27715351/yeast-%C3%AE-glucan-modulates-inflammation-and-waist-circumference-in-overweight-and-obese-subjects
#3
Krittiya Mosikanon, Dumrongkiet Arthan, Aikkarach Kettawan, Rungsunn Tungtrongchitr, Pattaneeya Prangthip
Increased inflammation occurs with excessive adiposity and yeast β-glucan modulates immune responses. This study investigated the potential effect of yeast β-glucan on inflammatory cytokines in overweight/obese people. A randomized, double blinded, placebo-controlled, clinical trial design enrolled 44 overweight/obese participants with body mass index ≥23 kg/m(2), randomized to two groups receiving β-glucan 477 mg/capsule (n = 22) or placebo (n = 22) orally for six weeks. At weeks one to two, participants received 1 β-glucan or placebo capsule/day and at four weeks two tablets/day...
August 11, 2016: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/27671514/maternal-serum-and-cervicovaginal-il-6-in-patients-with-symptoms-of-preterm-labor
#4
Parisa Yavari Kia, Behzad Baradaran, Mahnaz Shahnazi, Mohammad Asghari Jafarabadi, Vahid Khaze, Shakiba Pourasad Shahrak
BACKGROUND: Preterm birth is a common problem in obstetrics. OBJECTIVE: To measure maternal serum interlukin-6 in mothers with preterm uterine contractions and compare it with cervicovaginal interlukin-6 in the same women. METHODS: In this cross-sectional study, we measured interlukin-6 in the sera and cervicovaginal fluids of 86 women with preterm uterine contractions. All participants had an intact membrane. Interlukin-6 was measured by using ELISA method...
September 2016: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/27613946/supervised-vigorous-intensity-exercise-intervention-for-depressed-female-smokers-a-pilot-study
#5
Christi A Patten, Carrie A Bronars, Kristin S Vickers Douglas, Michael H Ussher, James A Levine, Susannah J Tye, Christine A Hughes, Tabetha A Brockman, Paul A Decker, Ramona S DeJesus, Mark D Williams, Thomas P Olson, Matthew M Clark, Angela M Dieterich
INTRODUCTION: Few studies have evaluated exercise interventions for smokers with depression or other psychiatric comorbidities. This pilot study evaluated the potential role of supervised vigorous exercise as a smoking cessation intervention for depressed females. METHODS: Thirty adult women with moderate-severe depressive symptoms were enrolled and randomly assigned to 12 weeks of thrice weekly, in person sessions of vigorous intensity supervised exercise at a YMCA setting (EX; n = 15) or health education (HE; n = 15)...
September 9, 2016: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/27608615/influance-of-regular-swimming-on-serum-levels-of-crp-il-6-tnf-%C3%AE-in-high-fat-diet-induced-type-2-diabetic-rats
#6
Rafighe Ghiasi, Farhad Ghadiri Soufi, Gisou Mohaddes, Alireza Alihemmati, Mohammad H Somi, Hadi Ebrahimi, Fariba Mirzaie Bavil, Mohammad R Alipour
Due to key role of inflammation in pathogenesis of type 2 diabetes mellitus (T2DM), aim of this study was evaluating the influance of regular swimming on serum levels of C-reactive protein (CRP), interlukin-6 (IL-6), tumor necrosis factor-α (TNF-α) in high-fat diet-induced diabetic rats. Fourty male Wistar rats were randomly divided into control, diabetic , exercise and diabetic-exercise groups (n = 10). Diabetes was induced by high-fat diet and streptozotocin (35 mg/kg, i.p.). In exercise groups, after induction of diabetes, animals were subjected to swimming (60 min/5 days a week) for 10 weeks...
September 9, 2016: General Physiology and Biophysics
https://www.readbyqxmd.com/read/27540524/overexpression-of-annexin-a1-suppresses-pro-inflammatory-factors-in-pc12-cells-induced-by-1-methyl-4-phenylpyridinium
#7
Abbas Kiani-Esfahani, Sedigheh Kazemi Sheykhshabani, Maryam Peymani, Motahare-Sadat Hashemi, Kamran Ghaedi, Mohammad Hossein Nasr-Esfahani
OBJECTIVE: Annexin A1 (ANXA1) is suggested to have anti-inflammatory function. However, the precise function of ANXA1 has remained unclear. In this study, we therefore examined the potency of ANXA1 in regulating reactive oxygen species (ROS) production and suppressing pro-inflammatory responses in PC12 cells induced by 1-methyl-4-phenylpyridinium (MPP+). MATERIALS AND METHODS: In this experimental study, cDNA of ANXA1 was cloned and inserted to the PGL268 pEpi-FGM18F vector to produce a recombinant PGL/ANXA1 vector for transfection into the PC12 cells...
July 2016: Cell Journal
https://www.readbyqxmd.com/read/27518187/mycobacterium-vaccae-nebulization-can-protect-against-asthma-in-balb-c-mice-by-regulating-th9-expression
#8
Chaoqian Li, Xiaohong Jiang, Mingjie Luo, Guangyi Feng, Qixiang Sun, Yiping Chen
Asthma is a heterogeneous disease characterized by chronic airway inflammation. CD4(+) T-helper 9 (Th9) cells are closely linked to asthma, helping to regulate inflammation and immunity. Epidemiological studies showed that mycobacteria infections are negatively associated with asthma. Our previous research showed that inactivated Mycobacterium phlei nebulization alleviated the airway hyperresponsiveness and inflammation of asthma. However, the relationship between Th9 cells and mycobacteria remains unknown...
2016: PloS One
https://www.readbyqxmd.com/read/27422737/-prognostic-value-of-interleukin-6-for-death-of-patients-with-sepsis
#9
Luis Alberto Pallás Beneyto, Olga Rodríguez Luis, Carmen Saiz Sánchez, Oscar Cotell Simón, Daniel Bautista Rentero, Vicente Miguel Bayarri
BACKGROUND AND OBJECTIVE: To see the influence of interlukin-6 (IL-6) as an inflammatory mediator in patients with systemic inflammatory response syndrome (SIRS) and sepsis, assessing whether their serum levels during their stay in intensive care unit (ICU) serve as an early mortality prognostic marker MATERIAL AND METHODS: A prospective observational cohort study with 203 ICU patients from a third level hospital. A descriptive analysis was made, X(2) test used to compare qualitative variables, T-Student test to compare quantitative ones...
October 7, 2016: Medicina Clínica
https://www.readbyqxmd.com/read/27377210/a-31-kda-seminal-plasma-heparin-binding-protein-reduces-cold-shock-stress-during-cryopreservation-of-cross-bred-cattle-bull-semen
#10
M K Patel, R S Cheema, A K Bansal, V K Gandotra
In the present study, a 31-kDa protein, purified from cattle bull seminal plasma heparin-binding proteins (SP-HBP), was characterized by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and mass spectrometry. Raw semen of six cross-bred bulls was treated with 31-kDa HBP before cryopreservation to observe its effect on motility, viability, hypo-osmotic swelling test, acrosome integrity, in vitro capacitation/acrosome reaction, and oxidative stress at pre-freeze and frozen-thawed phases of cryopreservation...
October 1, 2016: Theriogenology
https://www.readbyqxmd.com/read/27349463/microrna221-3p-modulates-ets-1-expression-in-synovial-fibroblasts-from-patients-with-osteoarthritis-of-temporomandibular-joint
#11
Jie Xu, Yu Liu, Mohong Deng, Jian Li, Hengxing Cai, Qinggong Meng, Wei Fang, Xing Long, Jin Ke
OBJECTIVE: This study aimed to screen differential expression of microRNAs (miRNAs), and investigate function of the specifically selected miRNA in synovial fibroblasts from patients suffering osteoarthritis of temporomandibular joint (TMJOA). METHODS: MiRNA microarray was used to select differentially expressed miRNAs between TMJOA and normal synovial fibroblasts. The expression of screened miRNA221-3p was quantified using real-time PCR, and its specific target gene was predicted by bioinformatics...
June 24, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27348628/hypoxia-stimulated-cardiac-fibroblast-production-of-il-6-promotes-myocardial-fibrosis-via-the-tgf-%C3%AE-1-signaling-pathway
#12
Jia-Hong Wang, Lan Zhao, Xin Pan, Nan-Nan Chen, Jian Chen, Qun-Lin Gong, Feng Su, Jian Yan, Yan Zhang, Shao-Heng Zhang
Interlukin-6 (IL-6) is a multifunctional cytokine produced by several cell types that has a role in fibrosis. Fibroblasts (FBs) maintain this underlying pathogenic change through regulation of IL-6 production; however, its potential functional role in regulating surrounding cellular structural changes during ischemic myocardial remodeling remains unexplored. Here, we generated FBs, cardiomyocytes (CMs), and blood vascular endothelial cells (ECs) from the ventricles of neonatal rats. IL-6 was then overexpressed in FBs and the cells were treated with IL-6 receptor inhibitor (IL6RI), TGF-β1 receptor inhibitor (TβRI), or MMP2/MMP9 inhibitor (MMPI) using monoculture or coculture models under hypoxic conditions...
August 2016: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/27347679/expression-of-inflammatory-and-cell-death-program-genes-and-comet-dna-damage-assay-induced-by-escherichia-coli-in-layer-hens
#13
Gamal M K Mehaisen, Mariam G Eshak, M I El Sabry, Ahmed O Abass
Modern methods of industrial poultry and egg production systems involve stressful practices that stimulate Escherichia coli (E. coli) activity causing endotoxic shock. This investigation was conducted to evaluate the expression of pro-inflammatory cytokines and cell death program genes and DNA damage induced by E. coli in the brain and liver tissues of laying hens. A total of two hundred and ten H&N brown layer hens with 20 week age, were used in this research. First, preliminary experiments were designed (60 hens in total) to establish the optimal exposure dose of E...
2016: PloS One
https://www.readbyqxmd.com/read/27222379/effects-of-wr1065-on-6-hydroxydopamine-induced-motor-imbalance-possible-involvement-of-oxidative-stress-and-inflammatory-cytokines
#14
Afshin Kheradmand, Alireza M Nayebi, Masoumeh Jorjani, Solmaz Khalifeh, Rasool Haddadi
Over production of reactive oxygen species (ROS) is postulated to be the main contributor in degeneration of nigrostriatal dopaminergic neurons. In this study we investigated the effects of WR1065, a free radical scavenger, on motor imbalance, oxidative stress parameters and inflammatory cytokines in CSF and brain of hemi-parkinsonian rats. Lesion of dopaminergic neurons was done by unilateral infusion of 6-hydroxydopamine into the central region of the substentia nigra pars compacta (SNc) to induce hemi-parkinsonism and motor imbalance in rats...
August 3, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27147522/mycobacterium-tuberculosis-pe13-rv1195-manipulates-the-host-cell-fate-via-p38-erk-nf-%C3%AE%C2%BAb-axis-and-apoptosis
#15
Hui Li, Qiming Li, Zhaoxiao Yu, Mingliang Zhou, Jianping Xie
PE/PPE family proteins are mycobacteria unique molecules, named after their N-terminal conserved PE (Pro-Glu) and PPE (Pro-Pro-Glu) domains. Mycobacterium tuberculosis (Mtb) PE family gene encoded cell surface proteins are previously reported to be involved in virulence and interaction with host. To explore the role of a novel PE member (PE13, Rv1195), M. smegmatis was used as surrogate host. The study showed that Rv1195 was a cell wall associated protein. Rv1195 can enhance the survival of recombinants under stress conditions such as H2O2, SDS, low pH...
July 2016: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/26989902/expression-of-heat-shock-protein-70-gene-and-its-correlation-with-inflammatory-markers-in-essential-hypertension
#16
MULTICENTER STUDY
Kamna Srivastava, Rajiv Narang, Jagriti Bhatia, Daman Saluja
OBJECTIVES: Hypertension is characterized by systemic high blood pressure and is the most common and important risk factor for the development of cardiovascular diseases. Studies have shown that the circulating levels of certain inflammatory markers such as tumor necrosis factor-alpha (TNF-alpha), interlukin-6 (IL-6), c-reactive protein (CRP), and tumor suppressor protein-53 (p53) are upregulated and are independently associated with essential hypertension. However, mechanism of increase in the levels of HSP70 protein is not clear...
2016: PloS One
https://www.readbyqxmd.com/read/26902915/affiliation-reward-and-immune-biomarkers-coalesce-to-support-social-synchrony-during-periods-of-bond-formation-in-humans
#17
Adi Ulmer-Yaniv, Ronit Avitsur, Yaniv Kanat-Maymon, Inna Schneiderman, Orna Zagoory-Sharon, Ruth Feldman
Social bonds are critical for survival and adaptation and periods of bond formation involve reorganization of neurobiological systems as mediated by social behavior. Theoretical accounts and animal studies suggest similarity between parent-infant and pair bonding, a hypothesis not yet directly tested in humans. In this study, we recruited three groups of human adults (N=189); parents who had their firstborn child in the last 4-6months, new lovers who began a romantic relationship within the past 4months, and non-attached singles...
August 2016: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/26805011/a-novel-murine-model-of-clostridium-sordellii-myonecrosis-insights-into-the-pathogenesis-of-disease
#18
Michael J Aldape, Clifford R Bayer, Amy E Bryant, Dennis L Stevens
Clostridium sordellii infections have been reported in women following natural childbirth and spontaneous or medically-induced abortion, injection drug users and patients with trauma. Death is rapid and mortality ranges from 70 to 100%. Clinical features include an extreme leukemoid reaction, the absence of fever, and only minimal pain or erythema at the infected site. In the current study, we developed a murine model of C. sordellii soft tissue infection to elucidate the pathogenic mechanisms. Mice received 0...
April 2016: Anaerobe
https://www.readbyqxmd.com/read/26791768/-the-orai1-antibody-treatment-for-a-mouse-model-of-allergic-rhinitis
#19
Lin Lin, Fei Dai, Tingyu Sun
OBJECTIVE: The aim of the study was to investigate whether Orai1 antibody intraperitoneal injection could improve the condition of allergic rhinitis (AR) in mice. METHODS: Twenty-four BALB/C mice (SPF grade) were classified into 4 groups (AR group, Control group, Experimental group 1 and experimental group 2) according to a random number table. A mouse model of AR was established (Control group was established by phosphate buffered solution), and experimental group 1 and Experimental group 2 were established through intraperitoneal injection of 100 μg and 150 μg Orai1 antibody respectively...
January 2016: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/26675131/l-3-n-butylphthalide-attenuates-neuroinflammatory-responses-by-downregulating-jnk-activation-and-upregulating-heme-oxygenase-1-in-lipopolysaccharide-treated-mice
#20
Chun-Yang Zhao, Hui Lei, Yu Zhang, Lin Li, Shao-Feng Xu, Jie Cai, Ping-Ping Li, Ling Wang, Xiao-Liang Wang, Ying Peng
Microglia activation-induced neuroinflammation contributes to neuronal damage in neurodegenerative diseases. Inhibition of microglia activation and reduction of major neurotoxic cytokines have been becoming a therapeutic strategy for neurodegenerative diseases. L-3-n-Butylphthalide (L-NBP) has shown the potent neuroprotective effects in stroke and Alzheimer's disease animal models. The present study investigated the immune modulatory effects of L-NBP on pro-inflammatory cytokines and microglia activation in brain tissue induced by systemic lipopolysaccharide (LPS) treatment in C57BL/6 mice...
2016: Journal of Asian Natural Products Research
keyword
keyword
41027
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"