Sergio Serrano-Villar, Camilla Tincati, Sajan C Raju, Johan S Sáenz, Elena Moreno, Rafael Bargiela, Alfonso Cabello-Ubeda, Elena Sendagorta, Alina Kurz, Jose A Perez Molina, Amparo de Benito, Johannes R Hov, Laura Fernandez-Lopez, Alfonso Muriel, Rosa Del Campo, Santiago Moreno, Marius Trøseid, Jana Seifert, Manuel Ferrer
Human papillomavirus can cause preinvasive, high-grade squamous intraepithelial lesions (HSILs) as precursors to cancer in the anogenital area, and the microbiome is suggested to be a contributing factor. Men who have sex with men (MSM) living with human immunodeficiency virus (HIV) have a high risk of anal cancer, but current screening strategies for HSIL detection lack specificity. Here, we investigated the anal microbiome to improve HSIL screening. We enrolled participants living with HIV, divided into a discovery (n = 167) and validation cohort (n = 46), and who were predominantly (93...
July 2023: Nature Medicine