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https://www.readbyqxmd.com/read/28424832/setting-up-a-community-based-cervical-screening-service-in-a-low-income-country-a-pilot-study-from-north-western-tanzania
#1
Nestory Masalu, Patrizia Serra, Dino Amadori, Jackson Kahima, Charles Majinge, Joyce Rwehabura, Oriana Nanni, Sara Bravaccini, Maurizio Puccetti, Rosario Tumino, Lauro Bucchi
OBJECTIVES: To report the results of a pilot study for a service for cervical cancer screening and diagnosis in north-western Tanzania. METHODS: The pilot study was launched in 2012 after a community-level information campaign. Women aged 15-64 years were encouraged to attend the district health centres. Attendees were offered a conventional Pap smear and a visual inspection of the cervix with acetic acid (VIA). RESULTS: The first 2500 women were evaluated...
April 19, 2017: International Journal of Public Health
https://www.readbyqxmd.com/read/28413146/-multiple-ground-glass-opacities-nodules
#2
D Moreau, V Gazaille, N Allou, C Fernandez, V André, M André
INTRODUCTION: Ground-glass opacities nodules are frequently detected with the advances of radiological imaging. These can be preinvasive lesions such as atypical adenomatous hyperplasia but also invasive lesions. It leads to question in patients with lung cancer about treatment strategy and follow up. CASE REPORT: We report the case of a 72 years-old woman followed for a lung adenocarcinoma with an EGFR mutation of the right upper lobe stage IIb. The CT scan shows multiple pure ground-glass opacities in the same lobe of the primitive tumor but also in the other lobe...
April 13, 2017: Revue de Pneumologie Clinique
https://www.readbyqxmd.com/read/28398952/vulvar-and-anal-intraepithelial-neoplasia-terminology-diagnosis-and-ancillary-studies
#3
REVIEW
Eric J Yang, Christina S Kong, Teri A Longacre
Currently, it is recognized that there is an HPV-related and an HPV-independent pathway to developing squamous cell carcinomas (SCC) in the anus and vulva. The majority of precursor lesions and SCC in the anus and vulva are high-risk HPV-associated, with HPV16 the most common type. Given the morphologic overlap and biological equivalence of HPV-related preinvasive squamous lesions of the lower anogenital tract, a unified, 2-tiered histopathologic nomenclature is now recommended. In contrast, mutations in the TP53 gene have been associated with HPV-independent vulvar and anal SCC...
May 2017: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/28386719/ct-and-histopathologic-characteristics-of-lung-adenocarcinoma-with-pure-ground-glass-nodules-10-mm-or-less-in-diameter
#4
Fang Wu, Shu-Ping Tian, Xin Jin, Rui Jing, Yue-Qing Yang, Mei Jin, Shao-Hong Zhao
OBJECTIVE: To evaluate CT and histopathologic features of lung adenocarcinoma with pure ground-glass nodule (pGGN) ≤10 mm in diameter. METHODS: CT appearances of 148 patients (150 lesions) who underwent curative resection of lung adenocarcinoma with pGGN ≤10 mm (25 atypical adenomatous hyperplasias, 42 adenocarcinoma in situs, 38 minimally invasive adenocarcinomas, and 45 invasive pulmonary adenocarcinomas) were analyzed for lesion size, density, bubble-like sign, air bronchogram, vessel changes, margin, and tumour-lung interface...
April 6, 2017: European Radiology
https://www.readbyqxmd.com/read/28352662/experimentally-induced-testicular-dysgenesis-syndrome-originates-in-the-masculinization-programming-window
#5
Sander van den Driesche, Karen R Kilcoyne, Ida Wagner, Diane Rebourcet, Ashley Boyle, Rod Mitchell, Chris McKinnell, Sheila Macpherson, Roland Donat, Chitranjan J Shukla, Anne Jorgensen, Ewa Rajpert-De Meyts, Niels E Skakkebaek, Richard M Sharpe
The testicular dysgenesis syndrome (TDS) hypothesis, which proposes that common reproductive disorders of newborn and adult human males may have a common fetal origin, is largely untested. We tested this hypothesis using a rat model involving gestational exposure to dibutyl phthalate (DBP), which suppresses testosterone production by the fetal testis. We evaluated if induction of TDS via testosterone suppression is restricted to the "masculinization programming window" (MPW), as indicated by reduction in anogenital distance (AGD)...
March 23, 2017: JCI Insight
https://www.readbyqxmd.com/read/28333845/changes-in-the-extracellular-matrix-are-associated-with-the-development-of-serous-tubal-intraepithelial-carcinoma-into-high-grade-serous-carcinoma
#6
Sophieke C H A van der Steen, Johan Bulten, Koen K Van de Vijver, Toin H van Kuppevelt, Leon F A G Massuger
OBJECTIVE: The identification of a marker for early progression of preinvasive lesions into invasive pelvic high-grade serous carcinoma (HGSC) may provide novel handles for innovative screening and prevention strategies. The interplay between cancer cells and the extracellular matrix (ECM) is one of the main principles in cancer development and growth, but has been largely neglected in preinvasive lesions. This is the first study addressing the involvement of the ECM in the "step-by-step" transition of normal fallopian tube epithelium into preinvasive lesions, and eventually the progression of preinvasive lesions into invasive HGSC...
March 23, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28331826/pulmonary-ground-glass-opacity-computed-tomography-features-histopathology-and-molecular-pathology
#7
REVIEW
Jian-Wei Gao, Stefania Rizzo, Li-Hong Ma, Xiang-Yu Qiu, Arne Warth, Nobuhiko Seki, Mizue Hasegawa, Jia-Wei Zou, Qian Li, Marco Femia, Tang-Feng Lv, Yong Song
The incidence of pulmonary ground-glass opacity (GGO) lesions is increasing as a result of the widespread use of multislice spiral computed tomography (CT) and the low-dose CT screening for lung cancer detection. Besides benign lesions, GGOs can be a specific type of lung adenocarcinomas or their preinvasive lesions. Evaluation of pulmonary GGO and investigation of the correlation between CT imaging features and lung adenocarcinoma subtypes or driver genes can be helpful in confirming the diagnosis and in guiding the clinical management...
February 2017: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/28325192/endoscopic-management-of-early-gastric-adenocarcinoma-and-preinvasive-gastric-lesions
#8
REVIEW
Saowanee Ngamruengphong, Seiichiro Abe, Ichiro Oda
Early gastric cancer (ECG) can be difficult to diagnose endoscopically. Endoscopists should be familiar with subtle changes and endoscopic features of EGC. Chromoendoscopy and image-enhanced endoscopy improve diagnostic accuracy and facilitate endoscopic resection. Endoscopic submucosal dissection is a preferred endoscopic technique for resection of EGC and offers a comparable overall survival to surgical resection. Endoscopic management of benign gastric epithelial polyps (fundic gland polyps, hyperplastic polyps, and gastric adenoma) depends on patient symptomatology, patient's comorbidities (eg, familial syndromes), lesions' characteristics, and risk of malignant transformation...
April 2017: Surgical Clinics of North America
https://www.readbyqxmd.com/read/28169235/prediction-of-heterogeneity-in-breast-cancer-immunophenotype-at-ductal-carcinoma-in-situ-stage
#9
Manish Rohilla, Amanjit Bal, Gurpreet Singh, Kusum Joshi
INTRODUCTION: Ductal carcinoma in situ (DCIS) is considered a heterogeneous lesion at the molecular level. However, there is a paucity of literature about the existence of molecular subtypes in DCIS which can predict their biological behavior at the preinvasive stage. MATERIALS AND METHODS: Precise prevalence of molecular subtypes of pure DCIS and DCIS component of infiltrating duct carcinoma (IDC) was evaluated using immunohistochemistry and correlated with known prognostic factors...
October 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28143875/epithelial-cell-migration-as-a-potential-therapeutic-target-in-early-lung-cancer
#10
REVIEW
Fraser R Millar, Sam M Janes, Adam Giangreco
Lung cancer is the most lethal cancer type worldwide, with the majority of patients presenting with advanced stage disease. Targeting early stage disease pathogenesis would allow dramatic improvements in lung cancer patient survival. Recently, cell migration has been shown to be an integral process in early lung cancer ontogeny, with preinvasive lung cancer cells shown to migrate across normal epithelium prior to developing into invasive disease. TP53 mutations are the most abundant mutations in human nonsmall cell lung cancers and have been shown to increase cell migration via regulation of Rho-GTPase protein activity...
January 2017: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/28139862/the-pd-1-pd-l1-axis-may-be-aberrantly-activated-in-occupational-cholangiocarcinoma
#11
Yasunori Sato, Masahiko Kinoshita, Shigekazu Takemura, Shogo Tanaka, Genya Hamano, Shoji Nakamori, Masahiro Fujikawa, Yasuhiko Sugawara, Takatsugu Yamamoto, Akira Arimoto, Minako Yamamura, Motoko Sasaki, Kenichi Harada, Yasuni Nakanuma, Shoji Kubo
An outbreak of cholangiocarcinoma in a printing company was reported in Japan, and these cases were regarded as an occupational disease (occupational cholangiocarcinoma). This study examined the expression status of programmed death-1 (PD-1) and programmed death-ligand 1 (PD-L1) in occupational cholangiocarcinoma. Immunostaining of PD-1, PD-L1, CD3, CD8, and CD163 was performed using tissue sections of occupational cholangiocarcinoma (n = 10), and the results were compared with those of control cases consisting of intrahepatic (n = 23) and extrahepatic (n = 45) cholangiocarcinoma...
March 2017: Pathology International
https://www.readbyqxmd.com/read/28121939/multiple-preinvasive-and-invasive-hpv-related-lesions-of-the-anogenital-tract-in-a-female-patient-with-hiv-infection-a-case-report
#12
Nicolò Clemente, Lara Alessandrini, Emanuela Vaccher, Antonino De Paoli, Monica Buttignol, Vincenzo Canzonieri, Francesco Sopracordevole
RATIONALE: Patients with human immunodeficiency virus (HIV) infection have been shown to be at increased risk for high-risk human papillomavirus (HR-HPV) infection of the anogenital tract. Furthermore, in the last decades, the introduction of highly active antiretroviral therapy (HAART) has increased the longevity of these patients who now live long enough to develop HPV-related cancers; hence, the impact of HPV infection on HIV-positive patients is of increasing concern. PATIENT CONCERNS: We reported the case of an HIV-positive female patient on HAART with a good virological and immunological response and with a long history of HPV-related intraepithelial and invasive lesions of the anogenital tract...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28119395/cone-depth-increases-risk-of-adverse-obstetric-outcomes-following-treatment-for-cervical-preinvasive-disease
#13
Alejandra Castanon
No abstract text is available yet for this article.
March 2017: Evidence-based Medicine
https://www.readbyqxmd.com/read/28091444/impact-of-visual-inspection-with-acetic-acid-plus-cryotherapy-see-and-treat-approach-on-the-reduction-of-the-population-burden-of-cervical-preinvasive-lesions-in-southeast-nigeria
#14
C O Chigbu, A K Onyebuchi, E F Nnakenyi, C C Egbuji
OBJECTIVE: The aim of this study is to determine the impact of visual inspection with acetic acid (VIA) plus immediate cryotherapy on the prevalence of VIA-detected cervical squamous intraepithelial lesion (SIL). METHODS: Women in four rural communities in Southeast Nigeria were screened with VIA. Women who tested positive to VIA were offered either immediate cryotherapy or large loop excision of the transformation zone based on predetermined eligibility criteria...
February 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28088318/correlation-of-the-hpv-detection-protein-expression-and-dna-content-in-cutaneous-pre-invasive-and-invasive-carcinoma-among-croatian-patients
#15
Kristina Meljanac Salopek, Stanko Jukić, Damir Babić
Development of cutaneous carcinomas has been associated with HPV infection. There have been various reports on p16, p53 and pRb expression in cutaneous carcinomas and on its linkage to HPV status. Association of protein expression and HPV infection with DNA content is not clear. The aim of this study was to determine a possible correlation between HPV type, protein expression and DNA content in both pre-invasive and invasive squamous cell carcinoma, as well as differences between studied groups in these parameters...
January 12, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28073359/whole-transcriptome-analysis-of-pre-invasive-and-invasive-early-squamous-lung-carcinoma-in-archival-laser-microdissected-samples
#16
Andre Koper, Leo A H Zeef, Leena Joseph, Keith Kerr, John Gosney, Mark A Lindsay, Richard Booton
BACKGROUND: Preinvasive squamous cell cancer (PSCC) are local transformations of bronchial epithelia that are frequently observed in current or former smokers. Their different grades and sizes suggest a continuum of dysplastic change with increasing severity, which may culminate in invasive squamous cell carcinoma (ISCC). As a consequence of the difficulty in isolating cancerous cells from biopsies, the molecular pathology that underlies their histological variability remains largely unknown...
January 10, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28055239/the-evolving-role-of-pathology-in-new-developments-classification-terminology-and-diagnosis-of-pancreatobiliary-neoplasms
#17
REVIEW
Michelle D Reid, Melinda M Lewis, Field F Willingham, N Volkan Adsay
Pancreatobiliary tract lesions are increasingly being discovered because of more sensitive imaging modalities. Magnetic resonance imaging has identified incidental pancreatic cysts in 13.5% of patients of progressively increasing age. Pancreatobiliary tissue is more accessible through endoscopic ultrasound and magnetic resonance imaging-guided biopsy procedures, and is now an integral part of pathologists' routine practice. Accordingly, several new tumor categories have been recently recognized, including intraductal tubulopapillary neoplasm, a new addition to tumoral intraepithelial neoplasms...
March 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/27977543/preinvasive-and-invasive-cervical-adenocarcinoma-preceding-low-risk-or-negative-pap-result-increases-time-to-diagnosis
#18
Lea A Moukarzel, Ana M Angarita, Christopher VandenBussche, Anne Rositch, Carol B Thompson, Amanda N Fader, Kimberly Levinson
OBJECTIVES: The aims of the study were to investigate screening histories of women with adenocarcinoma in situ (AIS) and adenocarcinoma (AdCa) of the cervix and to further evaluate screening for glandular disease. MATERIALS AND METHODS: Screening histories were retrospectively collected for patients with AIS or AdCa at a single large-volume academic institution from 2005 to 2015. Fisher exact and Wilcoxon rank sum tests were used to compare AIS with AdCa patient characteristics, distribution of preceding Pap (i...
April 2017: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/27941046/topical-1-5-fluoruracil-as-a-sole-treatment-of-corneoconjunctival-ocular-surface-squamous-neoplasia-long-term-study
#19
Raffaele Parrozzani, Luisa Frizziero, Sara Trainiti, Ilaria Testi, Giacomo Miglionico, Elisabetta Pilotto, Stella Blandamura, Ambrogio Fassina, Edoardo Midena
AIMS: To report long-term clinical outcome of topical 1% 5-fluoruracil (5-FU) as a sole treatment of ocular surface squamous neoplasia (OSSN). METHODS: 41 patients affected by OSSN were included. Each patient underwent full ophthalmological examination at baseline, with cytological or histological confirmation. Patients were treated by topical chemotherapy with 1% 5-FU four times a day for 4 weeks. One course was defined as 4 weeks of topical chemotherapy. Adjunctive courses were administered after 1 month of chemotherapy-free interval...
December 9, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27833960/p53-p16-and-ki67-immunoexpression-in-cutaneous-squamous-cell-carcinoma-and-its-precursor-lesions
#20
Alexandru Marinescu, Alex Emilian Stepan, Claudiu Mărgăritescu, Alis Magdalena Marinescu, Roxana Eugenia Zăvoi, Cristiana Eugenia Simionescu, Mihaela Niculescu
The incidence of cutaneous squamous cell carcinoma (CSCC) and its precursor lesions argues the research for validating markers that would define the biomolecular mechanisms behind the potential progression and aggressiveness of these lesions. In this study, we analyzed the expression of p53, p16 and Ki67 in 91 cases of CSCC and its precursors in relation with the histological prognostic parameters. The quantification of the immunohistochemical reactions indicated superior significant differences for the studied markers in squamous cell carcinomas compared to keratinocytic intraepithelial neoplasia (KIN)...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
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