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https://www.readbyqxmd.com/read/28708084/molecular-mechanisms-of-human-papillomavirus-induced-skin-carcinogenesis
#1
Martin Hufbauer, Baki Akgül
Infection of the cutaneous skin with human papillomaviruses (HPV) of genus betapapillomavirus (βHPV) is associated with the development of premalignant actinic keratoses and squamous cell carcinoma. Due to the higher viral loads of βHPVs in actinic keratoses than in cancerous lesions, it is currently discussed that these viruses play a carcinogenic role in cancer initiation. In vitro assays performed to characterize the cell transforming activities of high-risk HPV types of genus alphapapillomavirus have markedly contributed to the present knowledge on their oncogenic functions...
July 14, 2017: Viruses
https://www.readbyqxmd.com/read/28700998/a-decrease-of-histone-deacetylase-6-expression-caused-by-helicobacter-pylori-infection-is-associated-with-oncogenic-transformation-in-gastric-cancer
#2
Qing He, Guoqiang Li, Xin Wang, Shubin Wang, Jiang Hu, Lang Yang, Yuqi He, Yuanming Pan, Dedong Yu, Yun Wu
BACKGROUND: Histone deacetylase 6 (HDAC6) plays a role in the progression of many tumors. However, the relationship between the level of HDAC6 expression and gastric tumorigenesis is still unclear. Here, we illustrate the potential correlation between Helicobacter pylori (HP) infection and the variation of HDAC6 expression in different gastric lesions, as well as the clinical significance of HDAC6 expression in gastric cancer (GC) patients. MATERIALS AND METHODS: Between 2011 and 2016, 364 patients with different types of gastric lesions were enrolled in Baotou City Central Hospital...
July 13, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28698299/neat1-is-a-p53-inducible-lincrna-essential-for-transformation-suppression
#3
Stephano S Mello, Carolyn Sinow, Nitin Raj, Pawel K Mazur, Kathryn Bieging-Rolett, Daniela Kenzelmann Broz, Jamie F Conklin Imam, Hannes Vogel, Laura D Wood, Julien Sage, Tetsuro Hirose, Shinichi Nakagawa, John Rinn, Laura D Attardi
The p53 gene is mutated in over half of all cancers, reflecting its critical role as a tumor suppressor. Although p53 is a transcriptional activator that induces myriad target genes, those p53-inducible genes most critical for tumor suppression remain elusive. Here, we leveraged p53 ChIP-seq (chromatin immunoprecipitation [ChIP] combined with high-throughput sequencing) and RNA-seq (RNA sequencing) data sets to identify new p53 target genes, focusing on the noncoding genome. We identify Neat1, a noncoding RNA (ncRNA) constituent of paraspeckles, as a p53 target gene broadly induced by mouse and human p53 in different cell types and by diverse stress signals...
July 11, 2017: Genes & Development
https://www.readbyqxmd.com/read/28697153/mucin-expression-in-the-esophageal-malignant-and-premalignant-states-a-systematic-review-and-meta-analysis
#4
Yaron Niv, Samuel B Ho, Ronnie Fass, Theodore Rokkas
BACKGROUND: Mucins are heavily glycosylated glycoproteins, synthesized by mucosal surfaces and have an important role in healthy state and malignant diseases. Change in mucins synthesis or secretion may be primary event or secondary to inflammation or carcinogenesis. AIM: The aim of this study is to assess the current knowledge about mucin expression in esophageal lesions, and to establish a role for different mucin expressions as prognostic markers. METHOD: English Medical literature searches were conducted for "mucin" and "esophagus...
July 10, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28695432/gallbladder-polypoid-lesions-what-are-they-and-how-should-they-be-treated-a-single-center-experience-based-on-1446-cholecystectomy-patients
#5
Anan Xu, Yu Zhang, Hai Hu, Gang Zhao, Jinli Cai, Anhua Huang
BACKGROUND AND AIM: Gallbladder polypoid-lesions (GPs) are commonly seen on ultrasonography (USG), but several aspects of this problem are ill-defined. This study aimed to analyze clinic and pathologic characteristics of 1446 USG-detected GPs, identify predictive factors for cholesterol lesions and malignancy, and provide comments and recommendations on specific aspects of GPs. METHODS: We retrospectively analyzed clinic files of 1446 patients who underwent cholecystectomy for USG-detected GPs between 2008 and 2015 in Gallbladder Diseases Center, East Hospital of Tongji University...
July 10, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28692931/automatic-discrimination-of-actinic-keratoses-from-clinical-photographs
#6
Panagiota Spyridonos, Georgios Gaitanis, Aristidis Likas, Ioannis D Bassukas
BACKGROUND AND OBJECTIVE: Actinic keratoses (AK) are common premalignant skin lesions that can progress to invasive skin squamous cell carcinoma (sSCC). The subtle accumulation of multiple AK in aging individuals increases the risk of sSCC development, and this underscores the need for efficient treatment and patient follow-up. Our objectives were to develop a method based on color texture analysis of standard clinical photographs for the discrimination of AK from healthy skin and subsequently to test the developed approach in the quantification of field-directed treatment interventions...
July 3, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28692889/dynamic-real-time-in-vivo-confocal-laser-endomicroscopy-of-the-fallopian-tube-during-laparoscopy-in-the-prevention-of-ovarian-cancer
#7
Gautier Chene, Lauriane Chauvy, Annie Buenerd, Stéphanie Moret, Béatrice Nadaud, Philippe Chabert, Gery Lamblin
OBJECTIVES: Recently it has been postulated that most ovarian cancers have a tubal origin. The identification of preinvasive tubal lesions would be of great interest in the early diagnosis of ovarian cancer. Optical biopsy has been developed and validated in the detection of precancerous lesions (such as Barrett's oesophagus). The first objective of this study was to assess the feasibility of optical biopsy in the study of fallopian tubes during laparoscopy. The second objective was to describe the images in benign premalignant and malignant tubes with a histopathological and immunohistochemical (p53 and Ki67 expressions) correlation...
July 5, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28692051/transcriptional-regulation-of-ataxia-telangiectasia-and-rad3-related-protein-by-activated-p21-activated-kinase-1-protects-keratinocytes-in-uv-b-induced-premalignant-skin-lesions
#8
S Beesetti, J Mavuluri, R P Surabhi, T M Oberyszyn, K Tober, R S Pitani, L D Joseph, G Venkatraman, S K Rayala
Sun-induced skin lesions, in particular actinic keratosis, are generally considered as premalignant skin lesions that can progress into squamous cell carcinoma (SCC) and invasive SCC if left untreated. Therefore, understanding the molecular mechanisms by which the ultraviolet-B (UV-B)-exposed cells are being protected and the signaling pathways that promote the progression of certain premalignant skin lesions to malignant lesions will permit us to prevent or cure skin cancers. In the current study, we found that phospho-p21-activated kinase-1 (Pak1) and Pak1 expression was high in clinical samples of sunlight-induced premalignant skin lesions assessed by immunohistochemistry...
July 10, 2017: Oncogene
https://www.readbyqxmd.com/read/28692045/impact-of-histone-demethylase-kdm3a-dependent-ap-1-transactivity-on-hepatotumorigenesis-induced-by-pi3k-activation
#9
T Nakatsuka, K Tateishi, Y Kudo, K Yamamoto, H Nakagawa, H Fujiwara, R Takahashi, K Miyabayashi, Y Asaoka, Y Tanaka, H Ijichi, Y Hirata, M Otsuka, M Kato, J Sakai, M Tachibana, H Aburatani, Y Shinkai, K Koike
Epigenetic gene regulation linked to oncogenic pathways is an important focus of cancer research. KDM3A, a histone H3 lysine 9 (H3K9) demethylase, is known to have a pro-tumorigenic function. Here, we showed that KDM3A contributes to liver tumor formation through the phosphatidylinositol 3-kinase (PI3K) pathway, which is often activated in hepatocellular carcinoma. Loss of Kdm3a attenuated tumor formation in Pik3ca transgenic (Tg) mouse livers. Transcriptome analysis of pre-cancerous liver tissues revealed that the expression of activator protein 1 (AP-1) target genes was induced by PI3K activation, but blunted upon Kdm3a ablation...
July 10, 2017: Oncogene
https://www.readbyqxmd.com/read/28682984/incidence-and-predictors-of-adenoma-after-surgery-for-colorectal-cancer
#10
Joana Marques-Antunes, Diogo Libânio, Pedro Gonçalves, Mário Dinis-Ribeiro, Pedro Pimentel-Nunes
OBJECTIVE: Patients with colorectal cancer (CRC) are at increased risk for developing metachronous premalignant and malignant lesions. However, its real incidence and underlying risk factors are still unclear, and therefore quality measures for colonoscopy under this indication have not been completely established. The aim of this study was to assess the incidence of and risk factors for the development of adenomas after surgery for CRC. PATIENTS AND METHODS: A total of 535 patients submitted to curative surgery for CRC between January 2008 and December 2011 were selected and their clinical records and surveillance colonoscopies were reviewed...
August 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28682431/uptodate-in-the-assessment-and-management-of-intraductal-papillary-mucinous-neoplasms-of-the-pancreas
#11
D Pagliari, A Saviano, M L Serricchio, A A Dal Lago, M G Brizi, F Lanza, R Manfredi, A Gasbarrini, F Attili
Intraductal Papillary Mucinous Neoplasms (IPMNs) are the most common cystic tumors of the pancreas and are considered premalignant lesions. IPMNs are characterized by the papillary growth of the ductal epithelium with rich mucin production, which is responsible for cystic segmental or diffuse dilatation of the main pancreatic duct (MPD) and/or its branches. According to the different involvement of pancreatic duct system, IPMNs are divided into main duct type (MD-IPMN), branch duct type (BD-IPMN), and mixed type (MT-IPMN)...
June 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28682047/upper-gastrointestinal-conditions-nonmalignant-conditions-of-the-stomach
#12
Ku-Lang Chang, David S Estores
Functional dyspepsia can be categorized into two syndromes: postprandial distress syndrome and epigastric pain syndrome. Helicobacter pyloriinfection is one of the most common chronic infections worldwide. Acute H pylori infection causes dyspepsia, and chronic infection can cause peptic ulcer disease. H pylori also is one of the causative agents in gastric adenocarcinoma and mucosa-associated lymphoid tissue lymphoma. The incidence of H pylori infection varies among different ethnic populations and geographic locations...
July 2017: FP Essentials
https://www.readbyqxmd.com/read/28681085/reflectance-confocal-microscopic-evaluation-of-nonmelanocytic-lip-lesions
#13
Işın Sinem Bağcı, Mehmet Salih Gürel, Ayşe Esra Koku Aksu, Aslı Turgut Erdemir, Esma İnan Yüksel, Yeliz Karakoca Başaran
Lips display various benign and malignant lesions. Considering their functional and cosmetic importance, noninvasive diagnostic methods are required. In vivo reflectance confocal microscopy (RCM) has already been reported to be useful in the evaluation of various skin lesions. The aim of this study was to define the RCM features of nonmelanocytic lip lesions, compare them with healthy lip, and demonstrate the applicability of RCM as a noninvasive diagnostic method for nonmelanocytic lip lesions. Sixty-seven patients with premalignant/malignant, inflammatory, and infectious lip lesions and twenty-one healthy volunteers were included in the study...
July 5, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28667573/urologic-dermatology-a-review
#14
REVIEW
Andrew W Stamm, Kathleen C Kobashi, Ksenija B Stefanovic
PURPOSE OF REVIEW: Genital dermatology represents a challenge to many providers. Though dermatologic lesions involving the genitalia may present to any of a number of practices, ranging from primary care to urology, gynecology, and dermatology, few training programs provide significant training regarding the diagnosis and management of genital dermatologic lesions. The purpose of this review is to provide urologists with an overview of common genital dermatological lesions that may be encountered in a clinic...
August 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28658769/expression-of-podoplanin-in-laryngeal-squamous-cell-carcinoma-and-dysplasia
#15
Badawia Bayoumy Ibrahim, Mostafa Mohamed Salem, Rasha Ahmed Khairy, Reema Abdul Rahman Al Gunaid
INTRODUCTION: In human cancers, podoplanin expression and its correlation with tumour invasive potential raise its possible role as a diagnostic and prognostic marker for cancer. AIM: To investigate the immunohistochemical expression of podoplanin in laryngeal Squamous Cell Carcinoma (SCC) and dysplasia. MATERIALS AND METHODS: This study included a total of 60 archived, formalin fixed, paraffin embedded tissue blocks of 40 cases of laryngeal SCC and 20 cases of dysplastic lesions...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28657397/histological-outcomes-in-conventional-cervical-cytology-for-invasive-carcinoma-not-always-cancer
#16
Flávia Regina Peixoto Pereira, Leila Cristina Soares, Marco Aurélio Pinho de Oliveira
The value of cytology for the detection of invasive cancer remains unknown. We performed a retrospective cohort study with 884 patients diagnosed of premalignant lesions and invasive carcinoma in cytology. 382 (43.2%) of them had cytological results of high-grade squamous intraepithelial lesions (HSIL), 244 (27.6%) showed low-grade squamous intraepithelial lesions (LSIL), 120 (13.6%) patients had atypical squamous cells of undetermined significance (ASC-US), 67 (7.6%) patients with atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion (ASC-H), 38 (4...
June 28, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28644684/c-cell-and-follicular-epithelial-cell-precursor-lesions-of-the-thyroid
#17
Theresa Scognamiglio
CONTEXT: - The identification of precursor or dysplastic lesions in the thyroid is difficult. Pathology of the C cell has been extensively studied, and the preneoplastic nature of C-cell hyperplasia in the setting of familial medullary thyroid carcinomas is well established. However, the distinction between neoplastic and physiologic/reactive C-cell hyperplasia remains a challenge. Unlike C cells, the existence of a precursor lesion of follicular cell-derived tumors is less well established, and a dysplastic or preneoplastic follicular lesion has not been well defined...
June 23, 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28643319/-progress-of-the-application-of-optical-coherence-tomography-in-gastrointestinal-tumor-surgery
#18
Yongsheng Li, Hao Liu, Haipeng Huang, Yu Zhu, Haijun Deng, Jiang Yu, Site Luo, Li Huo, Li Lin, Huikai Xie, Guoxin Li
Optical coherence tomography (OCT) is a real-time, cross-sectional optical imaging technology. It is analogous to ultrasonography, except that OCT uses light waves instead of sound waves, and can provide three-dimensional morphological images of living tissues with a micrometer resolution. Through the use of endoscopes, needles, catheters and laparoscopes, OCT has demonstrated tremendous imaging potential in tumor surgery. The current studies suggest that OCT has potential for clinical applications in the following fields of gastrointestinal tumor surgery: (1) Early tumor detection and diagnosis: OCT can distinguish differences between polyp tissue, normal tissue and malignant tissue...
June 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28640478/usefulness-of-office-examination-with-narrow-band-imaging-for-the-diagnosis-of-head-and-neck-squamous-cell-carcinoma-and-follow-up-of-premalignant-lesions
#19
Isabel Vilaseca, Meritxell Valls-Mateus, Anna Nogués, Eduardo Lehrer, Mauricio López-Chacón, Francesc Xavier Avilés-Jurado, José Luis Blanch, Manuel Bernal-Sprekelsen
BACKGROUND: The purpose of this study was to evaluate the value of narrow band imaging (NBI) examination in the office for the diagnosis and follow-up of upper airway premalignant and malignant lesions. METHODS: Four hundred eighty lesions were evaluated with white light endoscopy (WLE) and NBI before a biopsy/excision. Additionally, 151 premalignant lesions were followed up without proven biopsy. Carcinoma-free survival was calculated. The learning curve was analyzed...
June 22, 2017: Head & Neck
https://www.readbyqxmd.com/read/28640134/association-between-pd-l1-and-hpv-status-and-the-prognostic-value-for-hpv-treatment-in-premalignant-cervical-lesion-patients
#20
Feng Yang-Chun, Cheng Zhen-Zhen, Huang Yan-Chun, Ma Xiu-Min
The difference of PD-L1 expression between only HPV-positive patients and premalignant cervical lesion patients did not be reported in present studies. And to test the PD-L1 expression in some cervical cell lesion studies using cervical exfoliated cells sample also was ignored. Meanwhile, the PD-L1 expression as a predictive biomarker still existed controversy. So in the study, first to compare the expression of PD-L1 between only HPV-positive patients and premalignant cervical lesion patients, then to research the association between PD-L1 and HPV status, lastly to explore the possible prognostic value for HPV treatment in premalignant cervical lesion patients...
June 2017: Medicine (Baltimore)
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