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https://www.readbyqxmd.com/read/29034442/correlation-between-tissue-expression-of-microrna-137-and-cd8-in-oral-lichen-planus
#1
Sana Maher Hasan Aghbari, Abdelrahman Ibrahim Abushouk, Olfat Gamil Shakir, Shaimaa Omar Zayed, Attia Attia
OBJECTIVES: Oral lichen planus (OLP) is a chronic, inflammatory condition, classified by the World Health Organization as a premalignant lesion. We performed this study to evaluate the correlation between microRNA-137 (miR-137) and CD8 oral tissue expression in OLP patients. MATERIALS AND METHODS: Twenty OLP patients [classified into three groups: (a) papular, reticular, or plaque; (b) atrophic; and (c) erosive] and 20 healthy controls were subjected to biopsy of the oral mucosa...
October 15, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29027524/-the-morphological-and-immunohistochemical-characteristics-of-stratified-mucin-producing-intraepithelial-lesion
#2
M V Shamarakova, A V Asaturova, L S Ezhova, M R Dumanovskaya, N M Faizullina, A V Kozachenko
Stratified mucin-producing intraepithelial lesion (SMILE) is a rare premalignant cervical lesion that combines the structural features of cervical intraepithelial neoplasia (CIN) and endocervical adenocarcinoma in situ (AIS). AIM: to analyze archival materials for the detection of SMILE and its subsequent morphological and immunohistochemical characterization. MATERIAL AND METHODS: Cervical cone specimens from 53 women with histologically verified CIN3 were examined...
2017: Arkhiv Patologii
https://www.readbyqxmd.com/read/29024327/effect-of-a-see-and-treat-clinic-on-skin-cancer-treatment-time
#3
Scott J P McLaughlin, John Kenealy, Michelle B Locke
BACKGROUND: Many plastic surgery departments in Australasia have experienced increasing referrals for management of skin lesions. This has driven a demand for new strategies to decrease patient waiting time and administrative costs. The aim of this study was to determine if a purpose-built See and Treat skin cancer clinic could provide a faster skin cancer treatment pathway with comparable clinical outcomes and acceptability to patients. METHODS: This was a prospective observational study of patients treated through the See and Treat clinic with a retrospective control cohort...
October 11, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29018057/pd-1-blockade-prevents-the-development-and-progression-of-carcinogen-induced-oral-premalignant-lesions
#4
Jin Wang, Tong-Xin Xie, Bingbing Wang, William N William, John Heymach, Adel K El-Naggar, Jeffrey N Myers, Carlos Caulin
Oral squamous cell carcinoma (OSCC) is preceded by progressive oral premalignant lesions (OPLs). Therefore, therapeutic strategies that prevent malignant progression of OPLs are expected to reduce the incidence of OSCC development. Immune checkpoint inhibitors that target the interaction of programmed death receptor 1 (PD-1) on T cells with the PD-1 ligand PD-L1 on cancer cells have been shown to extend the survival of patients with advanced OSCC. Here, we used the 4-Nitroquinoline-1-oxide (4-NQO) mouse model of oral carcinogenesis to test the hypothesis that PD-1 blockade may control the progression of OPLs...
October 10, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28990985/chapter-3-endometriosis-associated-ovarian-cancers
#5
Michael S Anglesio, Paul J Yong
Endometriosis-associated cancers include clear cell and endometrioid ovarian carcinoma. A history of endometriosis has long been considered to be a risk factor for later development of these malignancies; however, recent molecular genetic evidence has provided unequivocal evidence that these lesions are in fact the precursors for endometriosis-associated cancers. Herein, we will explore the relationship between endometriosis and ovarian carcinomas, similarities between the premalignant lesions and their cancerous counterparts, and the potential role of mutations and the ovarian microenvironment that may contribute to malignant transformation...
October 5, 2017: Clinical Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28983158/correlation-of-two-colposcopic-indices-for-predicting-premalignant-lesions-of-cervix
#6
Sweta Kushwah, Beenu Kushwah
Cervical cancer is the second most common malignancy among women in India, mainly affecting the females of Peri-Menopausal age group. Colposcopy has been very useful for diagnosing cervical cancer to guide the biopsy. Reids and Scalzi proposed the Reids Colposcopic Index (RCI) to make colposcopic diagnosis less subjective, which is currently the most accepted scoring system. Recognizing the correlation of size of the lesion with likelihood of harbouring high grade disease, a new scoring system, the Swede score, has been devised by Strander et al in 2005...
July 2017: Journal of Mid-life Health
https://www.readbyqxmd.com/read/28978111/tbx2-subfamily-suppression-in-lung-cancer-pathogenesis-a-high-potential-marker-for-early-detection
#7
Athar A Khalil, Smruthy Sivakumar, Frances Anthony San Lucas, Tina McDowell, Wenhua Lang, Kazuhiro Tabata, Junya Fujimoto, Yasushi Yatabe, Avrum Spira, Paul Scheet, Georges Nemer, Humam Kadara
The TBX2 subfamily (TBXs 2, 3, 4 and 5) transactivates or represses genes involved in lung organogenesis. Yet TBX2 subfamily expression in pathogenesis of non-small cell lung cancer (NSCLC), the most common lung malignancy, remains elusive. We sought to probe the expression profile of the TBX2 subfamily in early phases of NSCLC. Expression of TBX2 subfamily was analyzed in datasets of pan-normal specimens as well as NSCLCs and normal lung tissues. TBX2 subfamily expression in matched normal lungs, premalignant hyperplasias and NSCLCs was profiled by transcriptome sequencing...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28966966/toluidine-blue-staining-in-identification-of-a-biopsy-site-in-potentially-malignant-lesions-a-case-control-study
#8
Mayank Kumar Parakh, R C Jagat Reddy, Prabhu Subramani
OBJECTIVE: Oral cancer is a significant threat to public health all over the world, especially in Southeast Asia. At the present time, screening of oral cancer, its premalignant stages as well as its early detection, is still largely based on visual examination of the mouth. Visual examination is highly subjective and hence lacks the specificity and sensitivity. The objective of this study was to determine the usefulness of toluidine blue in marking a biopsy site in potentially malignant disorders...
October 2017: Asia-Pacific Journal of Oncology Nursing
https://www.readbyqxmd.com/read/28966031/multicenter-outcomes-of-robotic-reconstruction-during-the-early-learning-curve-for-minimally-invasive-pancreaticoduodenectomy
#9
Ammara A Watkins, Tara S Kent, William E Gooding, Ugo Boggi, Sri Chalikonda, Michael L Kendrick, R Matthew Walsh, Herbert J Zeh, A James Moser
BACKGROUND: Perceived excess morbidity during the early learning curve of minimally-invasive pancreaticoduodenectomy (MIPD) has limited widespread adoption. It was hypothesized that robot-assisted reconstruction (RA) after MIPD allows anastomotic outcomes equivalent to open pancreaticoduodenectomy (PD). METHODS: Intent to treat analysis of centrally audited data accrued during early adoption of RA-MIPD at five centers. RESULTS: CUSUM analysis of operating times at each center identified 92 RA-MIPD during the early learning curve...
September 28, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28964611/incidental-detection-of-colorectal-lesions-by-fdg-pet-ct-scans-in-melanoma-patients
#10
Christopher J Young, Assad Zahid, Ian Choy, John F Thompson, Robyn P M Saw
BACKGROUND: Increased use of PET/CT scans in oncology patients has raised detection of Colorectal incidentalomas (CIs). The frequency and diagnostic outcomes of identifying these lesions in melanoma patients have not previously been studied. This studies primary objective was to determine the prevalence of CIs found on PET/CT scans in melanoma patients. The secondary objectives were to correlate the PET/CT findings with the pathology found at colonoscopy, and identify which patients were referred for colonoscopy...
September 19, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28953633/risk-factors-for-infection-by-oncogenic-human-papillomaviruses-in-hiv-positive-msm-patients-in-the-art-era-2010-2016
#11
Carmen Hidalgo-Tenorio, Concepción Gil-Anguita, Jessica Ramírez-Taboada, Javier Esquivias, Miguel A López-Ruz, Omar Mohamed Balgahata, Rosario Javier-Martinez, Juan Pasquau
Squamous cell carcinoma of anus (SCCA) is one of the most frequent non-AIDS-defining diseases in HIV patients, mainly in men who have sex with men (MSM), and it is associated with human papillomavirus (HPV) infection.To determine the prevalence of high-risk HPV (HR-HPV) genotypes, premalignant lesions (HSIL) and SCCA in a cohort of HIV-positive MSM; to study the distribution of HPV genotypes according to anal histology results; and to analyze risk factors for this infection.This prospective single-center study was conducted between May 2010 and September 2016...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28953155/bilateral-submental-flap-an-innovative-modification
#12
Kiran Gadre, Pushkar Gadre, Divya Singh, Anushri Shetty, Ankit Malu
Early management of premalignant lesions like oral submucous fibrosis cannot be underestimated in context of prevention and control of oral malignancies. Soft tissue reconstruction of the oral cavity and face is a complex undertaking. Several flaps local and distant as well as microvascular are available, each with their pros and cons. Microvascular free flaps lay a considerable burden on resources, expertise, increased operating time, and logistics. Simple and technically reproducible alternatives are needed to tackle these issues, more so in developing countries like ours...
September 25, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28951454/genomic-landscape-of-atypical-adenomatous-hyperplasia-reveals-divergent-modes-to-lung-adenocarcinoma
#13
Smruthy Sivakumar, F Anthony San Lucas, Tina L McDowell, Wenhua Lang, Li Xu, Junya Fujimoto, Jianjun Zhang, P Andrew Futreal, Junya Fukuoka, Yasushi Yatabe, Steven M Dubinett, Avrum E Spira, Jerry Fowler, Ernest T Hawk, Ignacio I Wistuba, Paul Scheet, Humam Kadara
There is a dearth of knowledge about the pathogenesis of premalignant lung lesions, especially for atypical adenomatous hyperplasia (AAH), the only known precursor for the major lung cancer subtype adenocarcinoma (LUAD). In this study, we performed deep DNA and RNA sequencing analyses of a set of AAH, LUAD and normal tissues. Somatic BRAF variants were found in 5/22 (23%) of AAH patients, 4/5 of whom had matched LUAD with driver EGFR mutations. KRAS mutations were present in all ever-smoker cases in the cohort (18%) exclusive of the cases with BRAF mutations...
September 26, 2017: Cancer Research
https://www.readbyqxmd.com/read/28947884/expression-of-vitamin-d-receptor-and-vitamin-d-status-in-patients-with-oral-neoplasms-and-effect-of-vitamin-d-supplementation-on-quality-of-life-in-advanced-cancer-treatment
#14
Akshay Anand, Suyash Singh, Abhinav A Sonkar, Nuzhat Husain, Kul Ranjan Singh, Sudhir Singh, Jitendra K Kushwaha
AIM OF THE STUDY: Vitamin D receptor (VDR) expression and serum vitamin D scores in oral premalignant lesions and oral cancer have not been widely analyzed. The role of vitamin D supplementation in advanced oral cancer for improving quality of life (QOL) is also a matter of research. MATERIAL AND METHODS: Vitamin D receptor expression and vitamin D scores were analyzed in normal oral mucosa (n = 95), leukoplakia (n = 23) and oral cancer (n = 87). 45 patients with advanced oral cancer subjected to chemoradiation were evaluated for the effect of vitamin D supplementation on most observable QOL parameters such as oral mucositis, swallowing performance and overall QOL...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/28947866/factors-associated-with-gastric-adenocarcinoma-and-dysplasia-in-patients-with-chronic-gastritis-a-population-based-study
#15
Jie Xing, Li Min, Shengtao Zhu, Hao Zhang, Yu Zhao, Hengcun Li, Zheng Zhang, Peng Li, Shutian Zhang
OBJECTIVE: Gastric cancer (GC) is one of the leading causes of death in China and other Asian countries. Recently, gastric endoscopy has become the main approach for GC screening, but the identification of high-risk individuals remains a challenge in GC screening programs. METHODS: There were 7,302 patients with chronic gastritis involved in this study. Endoscopic examinations were performed, and their demographic characteristics and lifestyle data were collected...
August 2017: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/28940583/molecular-genotyping-of-noninvasive-encapsulated-follicular-variant-of-papillary-thyroid-carcinoma
#16
Tae Hyuk Kim, Minju Lee, Ah-Young Kwon, Jun-Ho Choe, Jung-Han Kim, Jee Soo Kim, Soo Yeon Hahn, Jung Hee Shin, Man Ki Chung, Young Ik Son, Chang-Seok Ki, Hyun Sook Yim, Yoo-Li Kim, Jae Hoon Chung, Sun Wook Kim, Young Lyun Oh
AIM: Noninvasive encapsulated follicular variant of papillary thyroid carcinoma (FVPTC) has been managed as low-risk malignancy. Recently, a proposal was made to reclassify this tumor type as a premalignant lesion and rename it noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). However, a comprehensive study on molecular genotype-phenotype correlations of encapsulated FVPTC is lacking. METHODS AND RESULTS: This study consisted of 177 consecutive FVPTCs from January 2014 to April 2016...
September 20, 2017: Histopathology
https://www.readbyqxmd.com/read/28940516/analysis-of-clonal-expansions-through-the-normal-and-premalignant-human-breast-epithelium-reveals-the-presence-of-luminal-stem-cells
#17
Biancastella Cereser, Marnix Jansen, Emily Austin, George Elia, Taneisha McFarlane, Carolien Hm van Deurzen, Anieta M Sieuwerts, Maria G Daidone, Paul J Tadrous, Nicholas A Wright, Louise Jones, Stuart Ac McDonald
It is widely accepted that the cell of origin of breast cancer is the adult mammary epithelial stem cell, however demonstrating the presence and location of tissue stem cells in the human breast has proved difficult. Furthermore, we do not know the clonal architecture of the normal and premalignant mammary epithelium or its cellular hierarchy. Here we use deficiency in the mitochondrial enzyme cytochrome c oxidase (CCO), typically caused by somatic mutations in the mitochondrial genome, as a means to perform lineage tracing in the human mammary epithelium...
September 22, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28939930/-upper-abdominal-pain-and-febrile-episodes-in-a-44-year-old-filipino-woman
#18
A Deimel, J Sturm, T Vielfort, T Zöpf
A 44-year-old Filipino woman presented with abdominal pain and fever. Clinical examination and blood tests revealed no pathological results; however, (cross-sectional) imaging showed saccular cystic bile duct dilatation in the right liver with solid intraductal masses. Due to the clinical presentation the patient was admitted for surgical intervention with the diagnosis of Caroli disease. During the surgical procedure histopathology showed an intraductal papillary neoplasm of the bile duct (IPNB). The planned segmentetomy was extended to hemihepatectomy...
September 22, 2017: Der Internist
https://www.readbyqxmd.com/read/28938534/targeting-of-the-mapk-and-akt-pathways-in-conjunctival-melanoma-shows-potential-synergy
#19
Jinfeng Cao, Renier C Heijkants, Aart G Jochemsen, Mehmet Dogrusöz, Mark J de Lange, Pieter A van der Velden, Sjoerd H van der Burg, Martine J Jager, Robert M Verdijk
PURPOSE: Conjunctival melanoma (CM) is a rare but lethal form of cancer. Similar to cutaneous melanoma, CM frequently carries activating mutations in BRAF and NRAS. We studied whether CM as well as conjunctival benign and premalignant melanocytic lesions express targets in the mitogen-activated protein kinase (MAPK) and AKT pathways, and whether specific inhibitors can suppress CM growth in vitro. METHODS: 131 conjunctival lesions obtained from 129 patients were collected...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28932035/epigenetics-in-oral-squamous-cell-carcinoma
#20
REVIEW
K N Hema, T Smitha, H S Sheethal, S Angeline Mirnalini
Oral squamous cell carcinoma (OSCC) is the most common type of oral neoplasm, accounting for over 90% of all oral malignancies and 38% of head and neck tumors. Worldwide, OSCC is the eighth most common human cancer, with more than 500,000 new cases being diagnosed every year with a fairly onerous prognosis, encouraging further research on factors that might modify disease outcome. Genetic and/or environmental risk factors associated with the development of oral cancer have been sufficiently understood (smoking, alcohol, betel, diet, living habits, etc...
May 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
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