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https://www.readbyqxmd.com/read/28817367/nutrition-implications-for-long-term-survivors-of-pancreatic-cancer-surgery
#1
Maria Q B Petzel, Leah Hoffman
With slowly increasing survival rates in pancreatic cancer and international consensus guidelines recommending surgical resection of premalignant lesions, survival post-pancreatic resection is increasing. With longer survival time, the significant comorbidities of such major surgery have far-reaching effects on the nutrition status of the survivor of pancreatic cancer. This review describes the many nutrition-related side effects of pancreatic surgery, including the development of pancreatic enzyme insufficiency, micronutrient deficiencies, diabetes, fatty liver, and metabolic bone disease...
August 1, 2017: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/28816192/tobacco-abuse-and-associated-oral-lesions-among-interstate-migrant-construction-workers
#2
Anzil Ks Ali, Arshad Mohammed, Archana A Thomas, Shann Paul, M Shahul, K Kasim
AIM: The present study was conducted to assess the prevalence of tobacco use and associated oral mucosal lesions among construction workers of Cochin, Kerala, India. MATERIALS AND METHODS: A cross-sectional study was carried at various construction sites of Cochin and 2,163 workers were selected using multistage sampling method and were interviewed and examined. Information regarding demographic details, form, type, frequency of tobacco use, earlier attempt to quit, and willingness to quit tobacco use was obtained using predesigned questionnaire...
August 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28816019/itraq-based-quantitative-proteomic-analyses-of-high-grade-esophageal-squamous-intraepithelial-neoplasia
#3
Jingjing Zhang, Chunchun Zhi, Fuxi Zhen, Xiaoqin Yuan, Chunhua Jiao, Hong Zhu, Hui Zhu, Yadong Feng
PURPOSE: Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers worldwide and is the fourth most lethal cancer in China. Little is known about the proteome of high grade esophageal squamous intraepithelial neoplasia (HGN), which is a premalignant lesion of ESCC. EXPERIMENTAL DESIGN: A quantitative proteomic analysis using an Isobaric Tags for Relative and Absolute Quantification (iTRAQ) approach was used to characterize the protein expression profiles in HGN...
August 16, 2017: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/28814981/cpg-location-and-methylation-level-are-crucial-factors-for-the-early-detection-of-oral-squamous-cell-carcinoma-in-brushing-samples-using-bisulfite-sequencing-of-a-13-gene-panel
#4
Luca Morandi, Davide Gissi, Achille Tarsitano, Sofia Asioli, Andrea Gabusi, Claudio Marchetti, Lucio Montebugnoli, Maria Pia Foschini
BACKGROUND: Oral squamous cell carcinoma (OSCC) is usually diagnosed at an advanced stage and is commonly preceded by oral premalignant lesions. The mortality rates have remained unchanged (50% within 5 years after diagnosis), and it is related to tobacco smoking and alcohol intake. Novel molecular markers for early diagnosis are urgently needed. The purpose of this study was to evaluate the diagnostic value of methylation level in a set of 18 genes by bisulfite next-generation sequencing...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28813198/radial-scars-of-the-breast-encountered-at-core-biopsy-review-of-histologic-imaging-and-management-considerations
#5
Michael A Cohen, Mary S Newell
OBJECTIVE: The purposes of this article are to place the controversy over the management of radial scars diagnosed at core biopsy in perspective and to define reasonable management options. CONCLUSION: The management of radial scars after image-guided core biopsy of the breast for diagnosis remains controversial. Although current literature suggests no premalignant potential of these lesions, it does not fully explain the small but real percentage of these lesions that are upgraded to malignancy after surgical excision...
August 16, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28812059/clinician-s-update-on-the-benign-premalignant-and-malignant-skin-tumours-of-the-vulva-the-dermatologist-s-view
#6
REVIEW
Freja Lærke Sand, Simon Francis Thomsen
Correct and rapid diagnosis of skin tumours often requires biopsy and histopathological examination to differentiate benign lesions such as seborrhoeic keratoses or melanocytic naevi from premalignant and malignant lesions such as malignant melanoma. Particularly, to the untrained eye, any benign skin tumour-pigmented or nonpigmented-is easily mistaken for a malignant lesion. Qualified clinical evaluation is paramount in order to reduce the frequency of unwarranted skin biopsies. Herein, the most common benign, premalignant, and malignant vulvar skin tumours are reviewed...
2017: International Scholarly Research Notices
https://www.readbyqxmd.com/read/28802955/hysterscopic-resection-of-premalignant-and-malignant-endometrial-polyps-is-it-a-safe-alternative-to-hysterectomy
#7
Osnat Elyashiv, Ron Sagiv, Ram Kerner, Ran Keidar, Joseph Menczer, Tally Levy
STUDY OBJECTIVE: The standard treatment of endometrial cancer (EC) and complex atypical hyperplasia (CAH) is hysterectomy with or without adnexectomy. In the last decade, several centers have attempted to perform hysteroscopic resection of malignant and pre-malignant polyps as an alternative to hysterectomy. In the present study, we evaluated the safety of this procedure in regard to residual uterine pathology. DESIGN: Retrospective chart review DESIGN CLASSIFICATION: Canadian Task Force classification II-2 SETTING: University hospital PATIENTS: 1766 women who underwent hysteroscopic polypectomy during the years 1998-2016 MEASUREMENTS: Patients with CAH and endometrioid type EC in the removed polyps who underwent hysterectomy were included in the study...
August 9, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28801702/paeonol-attenuates-aging-mrc-5-cells-and-inhibits-epithelial-mesenchymal-transition-of-premalignant-hacat-cells-induced-by-aging-mrc-5-cell-conditioned-medium
#8
Lihua Yang, Shangping Xing, Kun Wang, Hua Yi, Biaoyan Du
Senescence-associated secretory phenotype (SASP) factors, such as IL-6 and IL-8, are extremely critical in tissue microenvironment. Senescent human fibroblasts facilitate epithelial-mesenchymal transition (EMT) in premalignant epithelial cells mainly through the secretion of SASP factors. Meanwhile, premalignant human HaCaT Keratinocyte (HaCaT) cells as immortal epithelial cells are susceptible to malignant transformation. Paeonol, an herbal phenolic component found in peonies, exerts anti-aging and anti-tumor efficacies, while the molecular mechanisms of paeonol on EMT in premalignant HaCaT cells induced by SASP factors are unclear...
August 12, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28797444/straticyte-demonstrates-prognostic-value-over-oral-epithelial-dysplasia-grade-for-oral-potentially-malignant-lesion-assessment
#9
Jason T K Hwang, Ying R Gu, Benjamin J Dickson, Mi Shen, Ranju Ralhan, Paul G Walfish, David Mock, Kenneth P H Pritzker
OBJECTIVES: Straticyte™ was previously shown to be a more effective prognostic assessment than the current standard of care, histopathological dysplasia grading, to assess progression risk of oral epithelial dysplasia to invasive cancer [Hwang JT, Gu YR, Shen M, Ralhan R, Walfish PG, Pritzker KP, et al. Individualized five-year risk assessment for oral premalignant lesion progression to cancer. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017;123:374-81]. In this follow-up study, our aim is to confirm the prognostic value of Straticyte using an independent cohort of oral biopsy cases previously assessed as epithelial dysplasia of various grades...
September 2017: Oral Oncology
https://www.readbyqxmd.com/read/28791503/endoscopic-submucosal-dissection-for-esophagogastric-junction-tumors-a-single-center-experience
#10
Joong Keun Kim, Gwang Ha Kim, Bong Eun Lee, Chul Hong Park, Hye Kyung Jeon, Dong Hoon Baek, Geun Am Song
BACKGROUND: Surgical resection for esophagogastric junction (EGJ) tumors is more aggressive and worsens the quality of life of the patients and leads to poor prognosis even after surgery compared with tumors in other sites of the stomach. Endoscopic submucosal dissection (ESD) is a widely accepted treatment modality for premalignant lesions and early cancers in the stomach. However, EGJ tumor is one of the most technically difficult lesions to resect by ESD. Therefore, this study aimed to evaluate the therapeutic outcomes of ESD for EGJ epithelial neoplasms and to assess the predictive factors for incomplete resection...
August 8, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28791275/diagnostic-dilemma-in-cervical-endocervicosis
#11
Seung Hyun Lee, Jung-Woo Park, So Ra Oh, Seo Hee Rha
Müllerianosis is an embryonic Müllerian disease, resulting in the formation of the benign diseases adenomyosis, endometriosis, endosalpingiosis, and endocervicosis. Endocervicosis primarily affects the bladder, and rarely the cervix. Cervical endocervicosis, which is also a pseudoneoplastic glandular lesion, could be misinterpreted as a premalignant or even a malignant lesion. Because the treatment of these diseases is very different, early clinical diagnosis is important. Unfortunately, however, this lesion is difficult to diagnose preoperatively using clinical and radiological information, and pathological confirmation is needed...
July 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28780541/associations-between-highly-active-antiretroviral-therapy-and-the-presence-of-hpv-premalignant-and-malignant-cervical-lesions-in-sub-saharan-africa-a-systematic-review-current-evidence-and-directions-for-future-research
#12
Sonia Menon, Rodolfo Rossi, Natasha Zdraveska, Mbabazi Kariisa, Sushama D Acharya, Davy Vanden Broeck, Steven Callens
OBJECTIVES: In sub-Saharan Africa, substantial international funding along with evidence-based clinical practice have resulted in an unparalleled scale-up of access to antiretroviral treatment at a higher CD4 count. The role and timing of highly active antiretroviral therapy (HAART) in mediating cervical disease remains unclear. The aim of this article is to systematically review all evidence pertaining to Africa and identify research gaps regarding the epidemiological association between HAART use and the presence of premalignant/malignant cervical lesions...
August 4, 2017: BMJ Open
https://www.readbyqxmd.com/read/28768706/the-prevalence-of-cancer-associated-autoantibodies-in-patients-with-gastric-cancer-and-progressive-grades-of-premalignant-lesions
#13
Irēna Meistere, Simone Werner, Pawel Zayakin, Karīna Siliņa, Undīne Rulle, Angelina Pismennaja, Daiga Šantare, Ilze Kikuste, Sergejs Isajevs, Marcis Leja, Limas Kupčinskas, Juozas Kupčinskas, Laimas Jonaitis, Chun-Ying Wu, Hermann Brenner, Aija Linē, Zane Kalniņa
BACKGROUND: Serum autoantibodies against tumor-associated antigens (TAA) are detectable in early stage gastric cancer patients; however, the time point during cancerogenesis when they appear in circulation is still obscure. METHODS: In this study, we developed a recombinant antigen microarray and analyzed the prevalence of autoantibodies against 102 TAAs in 829 gastric cancer patients and 929 healthy controls from Caucasian and Asian populations, as well as 100 patients with chronic atrophic gastritis and 775 individuals staged according to different grades of intestinal metaplasia...
August 2, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28767028/-the-dutch-college-of-general-practitioners-practice-guideline-suspicious-skin-lesions
#14
Z Damen-van Beek, W Opstelten
- The Dutch College of General Practitioners practice guideline 'Suspicious skin lesions' provides recommendations for diagnosis, treatment and referral for the most common premalignant and malignant skin disorders.- The practice guideline includes a flowchart which starts by looking at the colour and surface of the skin lesion to direct the general practitioner to the most likely diagnosis.- In case of strong suspicion of squamous cell carcinoma, keratoacanthoma or melanoma and in case of basal cell carcinoma or Bowen's disease with high-risk characteristics, the general practitioner will refer the patient to a dermatologist...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28766561/editorial-management-of-the-small-asymptomatic-pancreatic-cyst-somehow-along-the-way-we-forgot-about-the-patient
#15
C Mel Wilcox
The incidentally identified pancreatic cyst is an increasing burden for both physicians and patients alike. Although we recognize that most of these lesions are benign and may not progress, a subset of these lesions are premalignant, may have frank cancer, and may progress over time. Most occur in older patients who have associated comorbidity. Recent studies highlight neoplastic features of these cysts that when present may warrant surgery or close long-term follow-up; however, there has been little study on the natural history factoring in patient comorbidity and pancreatic cancer-free survival...
August 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28761282/verruciform-xanthoma-of-the-tongue
#16
Sanjay Byakodi, Barun Kumar, Sandeep Patil, Swapnil Shinde
Verruciform xanthoma is a benign, soft tissue lesion occurring on the orogenital mucosa. Presentation of oral lesions can be pink, yellow, or gray raised plaque or papule with granular, papillary, or verrucous in nature. There are many theories proposed for the etiopathogenesis of verruciform xanthoma. Clinical observations may be misguiding as the lesion resembles malignant and premalignant lesions. Histopathological confirmation is essential for diagnosis and avoiding radical surgery. Once excised, the lesion does not recur...
January 2017: National Journal of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28760367/effects-of-metformin-on-endometrial-cancer-systematic-review-and-meta-analysis
#17
REVIEW
Cinthia G Meireles, Sidney A Pereira, Luciana P Valadares, Daniela F Rêgo, Luiz A Simeoni, Eliete N S Guerra, Adriana Lofrano-Porto
BACKGROUND: Endometrial cancer is one of the most common gynecological cancers, which is frequently preceded by atypical endometrial hyperplasia, a premalignant lesion. Metformin, an antidiabetic drug, has emerged as a new adjunctive strategy for different cancer types, including endometrial cancer. This systematic review and meta-analysis aimed to evaluate the effects of metformin in atypical endometrial hyperplasia and endometrial cancer patients. METHODS: The search was conducted on January 2017 and the articles were collected in Cochrane, LILACS, PubMed, Scopus and Web of Science...
July 28, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28758105/epigenetics-of-colorectal-cancer-emerging-circulating-diagnostic-and-prognostic-biomarkers
#18
REVIEW
Elisa Danese, Martina Montagnana
Colorectal cancer (CRC) is one of the most common cancers worldwide and the second leading cause of cancer-related mortality in western countries. Despite the high incidence, treatment options for advanced CRC remain limited and unsuccessful, resulting in a poor prognosis. Therefore, novel accurate diagnostic, prognostic and predictive biomarkers are clearly and urgently needed to detect advanced colon polyps and early stage CRC and to identify the most effective treatments for specific CRC patients. CRC is known to develop from early premalignant lesions to full blown cancer via a multi-step process involving a series of genetic mutations that accumulate over time...
July 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28754664/identification-of-a-human-airway-epithelial-cell-subpopulation-with-altered-biophysical-molecular-and-metastatic-properties
#19
Paul C Pagano, Linh M Tran, Nawal Bendris, Sean O'Byrne, Henry T Tse, Shivani Sharma, Jonathan W Hoech, Stacy J Park, Elvira L Liclican, Zhe Jing, Rui Li, Kostyantyn Krysan, Manash K Paul, Yari Fontebasso, Jill E Larsen, Shaina Hakimi, Atsuko Seki, Michael C Fishbein, James K Gimzewski, Dino Di Carlo, John D Minna, Tonya C Walser, Steven M Dubinett
Lung cancers are documented to have remarkable intratumoral genetic heterogeneity. However, little is known about the heterogeneity of biophysical properties, such as cell motility, and its relationship to early disease pathogenesis and micrometastatic dissemination. In this study, we identified and selected a subpopulation of highly migratory premalignant airway epithelial cells that were observed to migrate through microscale constrictions at up to 100-fold the rate of the unselected immortalized epithelial cell lines...
July 28, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28753702/probe-based-endomicroscopy-for-in-vivo-detection-of-gastric-intestinal-metaplasia-and-neoplasia-a-multicenter-randomized-controlled-trial
#20
Xiu-Li Zuo, Zhen Li, Chang-Qing Li, You-You Zheng, Li-Dong Xu, Jie Chen, Rong Lin, Jun Song, Chao-Hui Yu, Min Yue, Qi Zhou, Zhi-Yan Liu, Yan-Qing Li
Background and study aims Owing to the indistinctive endoscopic appearance of gastric intestinal metaplasia (GIM), gastric intraepithelial neoplasia (GIN), and early gastric cancer (EGC), a significant number of such lesions may be missed during surveillance endoscopy. The aim of this clinical trial was to assess the value of combined computed virtual chromoendoscopy (flexible spectral imaging color enhancement [FICE]) and probe-based confocal laser endomicroscopy (pCLE) for in vivo detection of GIM, GIN, and EGC...
July 28, 2017: Endoscopy
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