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https://www.readbyqxmd.com/read/28898537/stabilizing-an-amyloidogenic-%C3%AE-6-light-chain-variable-domain
#1
Oscar D Luna-Martínez, Alejandra Hernández-Santoyo, Myriam I Villalba-Velázquez, Rosalba Sánchez-Alcalá, D Alejandro Fernández-Velasco, Baltazar Becerril
Light chain amyloidosis is a lethal disease where vital organs are damaged by the fibrillar aggregation of monoclonal light chains. λ6a is an immunoglobulin light chain encoded by the germ line gene segment implicated in this disease. AR is a patient-derived germ line variant with a markedly low thermodynamic stability and prone to form fibrils in vitro in less than an hour. Here, we sought to stabilize this domain by mutating some residues back to the germ line sequence, and the most stabilizing mutations were the single mutant AR-F21I and the double mutant AR-F21/IV104L, both located in the hydrophobic core...
September 12, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28881644/engineering-a-high-affinity-humanized-anti-cd24-antibody-to-target-hepatocellular-carcinoma-by-a-novel-cdr-grafting-design
#2
Fumou Sun, Tong Wang, Jiahao Jiang, Yang Wang, Zhaoxiong Ma, Zhaoting Li, Yue Han, Mingzhu Pan, Jialing Cai, Min Wang, Juan Zhang
Cluster of differentiation 24 (CD24) is a specific surface marker involved in the tumorigenesis and progression of hepatocellular carcinoma (HCC). However, all reported anti-CD24 antibodies are murine ones with inevitable immunogenicity. To address this, a method using both molecular structure and docking-based complementarity determining region (CDR) grafting was employed for humanization. After xenogeneic CDR grafting into a human antibody, three types of canonical residues (in the VL/VH interface core, in the loop foundation, and interaction with loop residues) that support loop conformation and residues involved in the antigen-binding interface were back-mutated...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28839282/distributed-optical-fiber-sensors-with-ultrafast-laser-enhanced-rayleigh-backscattering-profiles-for-real-time-monitoring-of-solid-oxide-fuel-cell-operations
#3
Aidong Yan, Sheng Huang, Shuo Li, Rongzhang Chen, Paul Ohodnicki, Michael Buric, Shiwoo Lee, Ming-Jun Li, Kevin P Chen
This paper reports a technique to enhance the magnitude and high-temperature stability of Rayleigh back-scattering signals in silica fibers for distributed sensing applications. With femtosecond laser radiation, more than 40-dB enhancement of Rayleigh backscattering signal was generated in silica fibers using 300-nJ laser pulses at 250 kHz repetition rate. The laser-induced Rayleigh scattering defects were found to be stable from the room temperature to 800 °C in hydrogen gas. The Rayleigh scatter at high temperatures was correlated to the formation and modification of nanogratings in the fiber core...
August 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28777748/fully-automatic-mri-based-hippocampus-volumetry-using-fsl-first-intra-scanner-test-retest-stability-inter-field-strength-variability-and-performance-as-enrichment-biomarker-for-clinical-trials-using-prodromal-target-populations-at-risk-for-alzheimer-s-disease
#4
Enrica Cavedo, Per Suppa, Catharina Lange, Roland Opfer, Simone Lista, Samantha Galluzzi, Adam J Schwarz, Lothar Spies, Ralph Buchert, Harald Hampel
BACKGROUND: MRI-based hippocampus volume is a core clinical biomarker for identification of Alzheimer's disease (AD). OBJECTIVE: To assess robustness of automatic hippocampus volumetry with the freely available FSL-FIRST software with respect to short-term repeat and across field strength imaging. FSL-FIRST hippocampus volume (FIRST-HV) was also evaluated as enrichment biomarker for mild cognitive impairment (MCI) trials. METHODS: Robustness of FIRST-HV was assessed in 51 healthy controls (HC), 74 MCI subjects, and 28 patients with AD dementia from ADNI1, each with two pairs of back-to-back scans, one at 1...
July 29, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28776131/pure-distraction-injury-of-t1-2-with-quad-fever
#5
Jun-Yeong Seo, Chae-Moon Lim, Young-Hoon Kim, Kee-Yong Ha
INTRODUCTION: We report a pure distraction injury of the upper thoracic spine and uncontrolled hyperthermia without an infectious cause. Quad fever appears in the first several weeks to months after a cervical or upper thoracic SCI and is characterized by an extreme elevation in body core temperature beyond 40 °C without an infectious cause. Discriminating between infectious and noninfectious causes is important, and a thorough clinical assessment is required. MATERIALS AND METHODS: A 52-year-old male visited the emergency room complaining of back pain with complete paralysis [American Spinal Injury Association (ASIA) A] of both lower extremities after a pedestrian-motor vehicle accident...
August 3, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28653966/reliability-and-practicality-of-the-core-score-four-dynamic-core-stability-tests-performed-in-a-physician-office-setting
#6
Jason Friedrich, Rachel Brakke, Venu Akuthota, William Sullivan
OBJECTIVE: Pilot study to determine the practicality and inter-rater reliability of the "Core Score," a composite measure of 4 clinical core stability tests. DESIGN: Repeated measures. SETTING: Academic hospital physician clinic. PARTICIPANTS: 23 healthy volunteers with mean age of 32 years (12 females, 11 males). ASSESSMENT OF VARIABLES: All subjects performed 4 core stability maneuvers under direct observation from 3 independent physicians in sequence...
July 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28572078/the-effect-of-core-stabilization-exercise-on-the-kinematics-and-joint-coordination-of-the-lumbar-spine-and-hip-during-sit-to-stand-and-stand-to-sit-in-patients-with-chronic-nonspecific-low-back-pain-coscious-study-protocol-for-a-randomized-double-blind-controlled
#7
Mohammad Reza Pourahmadi, Ismail Ebrahimi Takamjani, Shapour Jaberzadeh, Javad Sarrafzadeh, Mohammad Ali Sanjari, Holakoo Mohsenifar, Rasool Bagheri, Morteza Taghipour
BACKGROUND: Chronic nonspecific low back pain (CNLBP) is among the most prevalent health problems. Lumbar spine and hips kinematics and coordination can be affected in CNLBP. The effects of exercises on the kinematics and coordination of lumbar spine and hips during sit-to-stand (STS) and its reverse have not been evaluated. OBJECTIVE: The aim of this study is to investigate the effect of core stabilization exercise on the kinematics and joint coordination of the lumbar spine and hip during STS and its reverse in CNLBP patients...
June 1, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28498224/core-training-in-low-back-disorders-role-of-the-pilates-method
#8
Andrew A Joyce, Dana H Kotler
The Pilates method is a system of exercises developed by Joseph Pilates, which emphasizes recruitment and strengthening of the core muscles, flexibility, and breathing, to promote stability and control of movement. Its focus bears similarity to current evidence-based exercise programs for low back disorders. Spinal stability is a function of three interdependent systems, osseoligamentous, muscular, and neural control; exercise addresses both the muscular and neural function. The "core" typically refers to the muscular control required to maintain functional stability...
May 2017: Current Sports Medicine Reports
https://www.readbyqxmd.com/read/28486863/the-influence-of-the-use-of-ankle-foot-orthoses-on-thorax-spine-and-pelvis-kinematics-during-walking-in-children-with-cerebral-palsy
#9
Eva Swinnen, Jean-Pierre Baeyens, Benjamin Van Mulders, Julian Verspecht, Marc Degelaen
BACKGROUND: To improve gait function in children with cerebral palsy, ankle-foot orthoses are often prescribed. However, until now, little attention has been devoted to the effect of ankle-foot orthoses on the postural control during walking in children with cerebral palsy. OBJECTIVES: The aim was to compare the differences in thorax, spine, and pelvis movements in children with cerebral palsy during walking barefoot and walking with ankle-foot orthoses. STUDY DESIGN: Clinical study with an intra subject design...
May 1, 2017: Prosthetics and Orthotics International
https://www.readbyqxmd.com/read/28472768/engineering-a-high-affinity-humanized-anti-cd24-antibody-to-target-hepatocellular-carcinoma-by-a-novel-cdr-grafting-design
#10
Fumou Sun, Tong Wang, Jiahao Jiang, Yang Wang, Zhaoxiong Ma, Zhaoting Li, Yue Han, Mingzhu Pan, Jialing Cai, Min Wang, Juan Zhang
Cluster of differentiation 24 (CD24) is a specific surface marker involved in the tumorigenesis and progression of hepatocellular carcinoma (HCC). However, all reported anti-CD24 antibodies are murine ones with inevitable immunogenicity. To address this, a method using both molecular structure and docking-based complementarity determining region (CDR) grafting was employed for humanization. After xenogeneic CDR grafting into a human antibody, three types of canonical residues (in the VL/VH interface core, in the loop foundation, and interaction with loop residues) that support loop conformation and residues involved in the antigenbinding interface were back-mutated...
April 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28432739/effect-of-a-4-week-elastic-resistance-band-training-regimen-on-back-kinematics-in-horses-trotting-in-hand-and-on-the-lunge
#11
T Pfau, V Simons, N Rombach, N Stubbs, R Weller
BACKGROUND: Training and rehabilitation techniques aiming at improving core muscle strength may result in increased dynamic stability of the equine vertebral column. A system of elastic resistance bands is suggested to provide proprioceptive feedback during motion to encourage recruitment of core abdominal and hindquarter musculature for improved dynamic stability. OBJECTIVES: To quantify the effects of a specific resistance band system on back kinematics during trot in-hand and lungeing at beginning and end of a 4-week exercise programme...
April 22, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/28425239/an-8-week-thoracic-spine-stabilization-exercise-program-improves-postural-back-pain-spine-alignment-postural-sway-and-core-endurance-in-university-students-a-randomized-controlled-study
#12
Şeyda Toprak Çelenay, Derya Özer Kaya
BACKGROUND/AIM: To investigate the effects of an 8-week thoracic stabilization exercise program on back pain, spinal alignment, postural sway, and core endurance in university students. MATERIALS AND METHODS: University students were randomly allocated into exercise (n: 28) and control (n: 25) groups. The exercise program was carried out 3 days a week for 8 weeks. Postural pain, spinal alignment, postural sway, and core endurance were assessed via visual analogue scale, Spinal Mouse, Biodex Balance System, and McGill's trunk muscle endurance tests at the baseline and after 8 weeks of training...
April 18, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28413219/contemporary-biopsychosocial-exercise-prescription-for-chronic-low-back-pain-questioning-core-stability-programs-and-considering-context
#13
Peter Stilwell, Katherine Harman
This commentary explores the importance of considering the biopsychosocial model and contextual factors when prescribing exercise. Diverse exercise programs for patients with chronic low back pain (CLBP) produce similar outcomes, without one specific exercise protocol demonstrating clear superiority. One clear barrier to positive outcomes is poor exercise adherence. We suggest that there are certain common contextual factors present in all exercise prescription scenarios that may impact adherence and health-related outcomes...
March 2017: Journal of the Canadian Chiropractic Association
https://www.readbyqxmd.com/read/28413116/trunk-muscle-emg-during-intermediate-pilates-mat-exercises-in-beginner-healthy-and-chronic-low-back-pain-individuals
#14
Ivye L R Pereira, Bergson Queiroz, Jefferson Loss, César Amorim, Isabel C N Sacco
OBJECTIVE: The purpose of this study was to compare the electromyographic pattern of core muscles during intermediate Pilates mat exercises between healthy people and those with low back pain. METHODS: We evaluated healthy participants (n = 19; mean ± standard deviation [SD]: age 28 ± 8 years, body mass 65 ± 10 kg, height 160.0 ± 9.1 cm) and a low back pain group (n = 13; mean ± SD: age 30 ± 9 years, body mass 67 ± 12 kg, height 170.0 ± 6.6 cm). Electromyographic analysis assessed the multifidus, external oblique, internal oblique, and rectus abdominis muscles during classical Pilates exercises (single leg stretch, criss-cross, and dead bug)...
April 13, 2017: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/28395386/-effects-of-core-stability-training-on-masters-swimmers
#15
Margarete Esser
Background Back pain is a frequent problem for swimmers, especially for Masters swimmers. The cause seems to be insufficient core stability. Objective The goal of this study is to investigate whether specific core musculature training has a positive influence on low back pain and swimmers' perceived performance. Method Two groups (Masters swimmers and a control group) performed a guided 8-week training program. Changes in the core musculature were documented via tests carried out before and after the training program...
June 2017: Sportverletzung Sportschaden: Organ der Gesellschaft Für Orthopädisch-Traumatologische Sportmedizin
https://www.readbyqxmd.com/read/28186932/descriptive-analysis-of-a-1-1-physiotherapy-outpatient-intervention-post-primary-lumbar-discectomy-one-arm-of-a-small-scale-parallel-randomised-controlled-trial-across-two-uk-sites
#16
A Rushton, A Calcutt, N Heneghan, A Heap, L White, M Calvert, P Goodwin
OBJECTIVE: There is a lack of high-quality evidence for physiotherapy post lumbar discectomy. Substantial heterogeneity in treatment effects may be explained by variation in quality, administration and components of interventions. An optimised physiotherapy intervention may reduce heterogeneity and improve patient benefit. The objective was to describe, analyse and evaluate an optimised 1:1 physiotherapy outpatient intervention for patients following primary lumbar discectomy, to provide preliminary insights...
November 9, 2016: BMJ Open
https://www.readbyqxmd.com/read/28171779/trunk-muscle-activity-during-different-variations-of-the-supine-plank-exercise
#17
Joaquin Calatayud, Jose Casaña, Fernando Martín, Markus D Jakobsen, Juan C Colado, Pedro Gargallo, Álvaro Juesas, Víctor Muñoz, Lars L Andersen
BACKGROUND: Exercises providing neuromuscular challenges of the spinal muscles are desired for core stability, which is important for workers with heavy manual labour as well as people recovering from back pain. PURPOSE: This study evaluated whether using a suspended modality increases trunk muscle activity during unilateral or bilateral isometric supine planks. DESIGN: Cross-sectional. METHODS: Twenty university students participated in this cross-sectional study...
April 2017: Musculoskeletal Science & Practice
https://www.readbyqxmd.com/read/28042685/lumbopelvic-core-stabilization-exercise-and-pain-modulation-among-individuals-with-chronic-nonspecific-low-back-pain
#18
Aatit Paungmali, Leonard H Joseph, Patraporn Sitilertpisan, Ubon Pirunsan, Sureeporn Uthaikhup
BACKGROUND: Lumbopelvic stabilization training (LPST) may provide therapeutic benefits on pain modulation in chronic nonspecific low back pain conditions. This study aimed to examine the effects of LPST on pain threshold and pain intensity in comparison with the passive automated cycling intervention and control intervention among patients with chronic nonspecific low back pain. METHODS: A within-subject, repeated-measures, crossover randomized controlled design was conducted among 25 participants (7 males and 18 females) with chronic nonspecific low back pain...
January 2, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/27988805/critical-appraisal-of-some-factors-pertinent-to-the-functional-designs-of-the-gas-exchangers
#19
REVIEW
John N Maina
Respiration acquires O2 from the external fluid milieu and eliminates CO2 back into the same. Gas exchangers evolved under certain immutable physicochemical laws upon which their elemental functional design is hardwired. Adaptive changes have occurred within the constraints set by such laws to satisfy metabolic needs for O2, environmental conditions, respiratory medium utilized, lifestyle pursued and phylogenetic level of development: correlation between structure and function exists. After the inaugural simple cell membrane, as body size and structural complexity increased, respiratory organs formed by evagination or invagination: the gills developed by the former process and the lungs by the latter...
March 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/27913929/-inpatient-multimodal-pain-therapy-additive-value-of-neuromuscular-core-stability-exercises-for-chronic-back-pain
#20
F Giesche, H Streicher, M Maiwald, P Wagner
INTRODUCTION: The medical and healthcare economic burden caused by chronic lumbar back pain (CLBP) requires the use of interdisciplinary treatment approaches. The present study aimed to evaluate whether the effectiveness of inpatient multimodal pain therapy (MPT, operations and procedures (OPS) coding 8-918.02), can be increased by implementing additional neuromuscular core stability exercises (NCSE). MATERIAL AND METHODS: As part of a prospective controlled study, subjects with CLBP (n = 48, 17 males, 58...
December 2, 2016: Der Schmerz
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