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https://www.readbyqxmd.com/read/28916732/il-4-producing-b-cells-regulate-t-helper-cell-dichotomy-in-type-1-and-type-2-controlled-diseases
#1
Ramona Hurdayal, Hlumani H Ndlovu, Mélanie Revaz-Breton, Suraj P Parihar, Justin Komguep Nono, Melissa Govender, Frank Brombacher
Interleukin-4 (IL-4)-induced T helper (Th) 2 cells promote susceptibility to the protozoan parasite Leishmania major, while conferring immunity to the intestinal trematode Schistosoma mansoni Here, we report that abrogation of IL-4 receptor alpha (IL-4Rα) signaling on B cells in BALB/c mice (mb1(cre)IL-4Rα(-/lox)) transformed nonhealer BALB/c to a healer phenotype with an early type 1 and dramatically reduced type 2 immune response and an absence of ulceration and necrosis during cutaneous leishmaniasis. From adoptive reconstitution and mixed bone-marrow chimera studies in B cell-deficient (µMT) mice, we reveal a central role for B cell-derived IL-4 and IL-4Rα in the optimal induction of the susceptible type 2 phenotype to L...
September 15, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28914224/rapid-risk-assessment-report-for-schistosomiasis-epidemic-in-jianli-county-caused-by-the-sunk-oriental-star-cruise-ship
#2
Ziling Ni, Xiaodong Tan, Bei Liu, Zhaoyu Ying, Xudong Gao, Fen Yang
BACKGROUND: At 9:28 pm on June 1, 2015, the cruise ship "Oriental Star" sank into Yangtze River in Jianli County, with 422 people killed. When the accident occurred, the Chinese government took immediate action and dispatched more than 9000 rescuers. The risk for outbreak of schistosomiasis was increased because of the shipwreck. Obviously it is critical to carry out risk assessment as soon as possible. METHODS: By means of the Delphi method, the situation was analyzed so that the government could fathom the severity of the accident...
September 15, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/28911129/a-comparative-study-on-the-efficacy-of-praziquantel-and-albendazole-in-the-treatment-of-urinary-schistosomiasis-in-adim-cross-river-state-nigeria
#3
S A Ben, M F Useh
Background: Praziquantel (PZQ) is the current drug of choice for the treatment of urinary schistosomiasis in endemic areas. It is very efficacious, although the potential for the development of resistance has been reported in some endemic areas among human subjects and in animal studies. Its' limitation include high cost and administration of multiple numbers of tablets. Albendazole (ALB) is used in the treatment of intestinal helminths infection. It is a broad-spectrum single-dose antihelminthic with an excellent cure rate and safety criteria...
September 1, 2017: International Health
https://www.readbyqxmd.com/read/28910994/paediatric-and-maternal-schistosomiasis-shifting-the-paradigms
#4
Amaya L Bustinduy, J Russell Stothard, Jennifer F Friedman
Background: In endemic areas, schistosomiasis causes both overt and subclinical disease in young children and their mothers, as well as in returned travellers. Sources of data: Key recently published literature. Areas of agreement: An action plan for paediatric schistosomiasis and female genital schistosomiasis (FGS) is needed with expanded access to praziquantel (PZQ) treatment required. Areas of controversy: Schistosomiasis-related morbidity is underappreciated...
September 1, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/28906438/acetylcholinesterase-and-nicotinic-acetylcholine-receptors-in-schistosomes-and-other-parasitic-helminths
#5
REVIEW
Hong You, Chang Liu, Xiaofeng Du, Donald P McManus
Schistosomiasis, which is caused by helminth trematode blood flukes of the genus Schistosoma, is a serious health and economic problem in tropical areas, and the second most prevalent parasitic disease after malaria. Currently, there is no effective vaccine available and treatment is entirely dependent on a single drug, praziquantel (PZQ), raising a significant potential public health threat due to the emergence of PZQ drug resistance. It is thus urgent and necessary to explore novel therapeutic targets for the treatment of schistosomiasis...
September 14, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28902908/histological-assessment-of-granulomas-in-natural-and-experimental-schistosoma-mansoni-infections-using-whole-slide-imaging
#6
Kátia B Amaral, Thiago P Silva, Felipe F Dias, Kássia K Malta, Florence M Rosa, Sócrates F Costa-Neto, Rosana Gentile, Rossana C N Melo
The pathology of schistosomiasis mansoni, a neglected tropical disease of great clinical and socioeconomic importance, results from the parasite eggs that become trapped in host tissues, particularly in the liver and intestines. Continuous antigenic stimulation from these eggs leads to recruitment of inflammatory cells to the sites of infection with formation of periovular granulomas. These complex structures have variable size and composition and are the most striking histopathological feature of schistosomiasis mansoni...
2017: PloS One
https://www.readbyqxmd.com/read/28899362/nationwide-cross-sectional-survey-of-schistosomiasis-and-soil-transmitted-helminthiasis-in-sudan-study-protocol
#7
Seungman Cha, Sung-Tae Hong, Young-Ha Lee, Keon Hoon Lee, Dae Seong Cho, Jinmoo Lee, Jong-Yil Chai, Mousab Siddig Elhag, Soheir Gabralla Ahmad Khaled, Mustafa Khidir Mustafa Elnimeiri, Nahid Abdelgadeir Ali Siddig, Hana Abdelrazig, Sarah Awadelkareem, Azza Tag Eldin Elshafie, Hassan Ahmed Hassan Ahmed Ismail, Mutamad Amin
BACKGROUND: Schistosomiasis and soil-transmitted helminthiasis (STHs) are target neglected tropical diseases (NTDs) of preventive chemotherapy, but the control and elimination of these diseases have been impeded due to resource constraints. Few reports have described study protocol to draw on when conducting a nationwide survey. We present a detailed methodological description of the integrated mapping of schistosomiasis and STHs on the basis of our experiences, hoping that this protocol can be applied to future surveys in similar settings...
September 12, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28898250/effects-of-proteasome-inhibitor-mg-132-on-the-parasite-schistosoma-mansoni
#8
Enyara R Morais, Katia C Oliveira, Renato G de Paula, Alice M M Ornelas, Érika B C Moreira, Fernanda Rafacho Badoco, Lizandra G Magalhães, Sergio Verjovski-Almeida, Vanderlei Rodrigues
Proteasome is a proteolytic complex responsible for intracellular protein turnover in eukaryotes, archaea and in some actinobacteria species. Previous work has demonstrated that in Schistosoma mansoni parasites, the proteasome inhibitor MG-132 affects parasite development. However, the molecular targets affected by MG-132 in S. mansoni are not entirely known. Here, we used expression microarrays to measure the genome-wide changes in gene expression of S. mansoni adult worms exposed in vitro to MG-132, followed by in silico functional analyses of the affected genes using Ingenuity Pathway Analysis (IPA)...
2017: PloS One
https://www.readbyqxmd.com/read/28893741/prevention-and-assessment-of-infectious-diseases-among-children-and-adult-migrants-arriving-to-the-european-union-european-economic-association-a-protocol-for-a-suite-of-systematic-reviews-for-public-health-and-health-systems
#9
Kevin Pottie, Alain D Mayhew, Rachael L Morton, Christina Greenaway, Elie A Akl, Prinon Rahman, Dominik Zenner, Manish Pareek, Peter Tugwell, Vivian Welch, Joerg Meerpohl, Pablo Alonso-Coello, Charles Hui, Beverley-Ann Biggs, Ana Requena-Méndez, Eric Agbata, Teymur Noori, Holger J Schünemann
INTRODUCTION: The European Centre for Disease Prevention and Control is developing evidence-based guidance for voluntary screening, treatment and vaccine prevention of infectious diseases for newly arriving migrants to the European Union/European Economic Area. The objective of this systematic review protocol is to guide the identification, appraisal and synthesis of the best available evidence on prevention and assessment of the following priority infectious diseases: tuberculosis, HIV, hepatitis B, hepatitis C, measles, mumps, rubella, diphtheria, tetanus, pertussis, poliomyelitis (polio), Haemophilus influenza disease, strongyloidiasis and schistosomiasis...
September 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28889378/defining-the-pathways-of-urogenital-schistosomiasis-associated-urothelial-carcinogenesis-through-transgenic-and-bladder-wall-egg-injection-models
#10
Evaristus C Mbanefo, Michael H Hsieh
Urogenital schistosomiasis (infection with Schistosoma haematobium) is a major cause of bladder carcinogenesis. However, the exact mechanisms of the sequelae leading up to the development of bladder cancer are poorly understood, mainly because of a dearth of tractable mouse models. We developed a mouse model of urogenital schistosomiasis through intramural injection of parasite eggs into the bladder wall to mimic the trapping of parasite eggs in the bladder. This approach recapitulates many of the sequelae observed in infected humans...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28887230/multiparticulate-system-combining-taste-masking-and-immediate-release-properties-for-the-aversive-compound-praziquantel
#11
Magdalena Münster, Corinna Schoch, Carsten Schmidt, Jörg Breitkreutz
The taste of pharmaceuticals is of particular importance as it highly affects the compliance of patients, especially for patient groups like children. In view of oral solid dosage forms, various taste masking techniques can be applied encapsulating the active pharmaceutical ingredient (API) to prevent the interaction with the taste buds. Despite a delayed drug release in saliva, an immediate drug release in gastrointestinal media is desirable for efficient drug absorption. This combinatory approach is of particular interest for poorly soluble drugs still demonstrating an aversive, bitter taste, e...
September 5, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28884235/a-cross-sectional-survey-comparing-a-free-treatment-program-for-advanced-schistosomiasis-japonica-to-a-general-assistance-program
#12
Langui Song, Xiaoying Wu, Beibei Zhang, Jiahua Liu, An Ning, Zhongdao Wu
The prevalence and intensity of schistosomiasis has dropped dramatically in China due to an effective integrated control program. However, advanced schistosomiasis is becoming a key challenge on the road to elimination. The aims of this study were to compare the disease condition between advanced cases under the general assistance program (GAP) and free treatment program (FTP) and to determine whether the FTP should be popularized to provide an objective reference for policymakers in China's advanced schistosomiasis control program...
September 7, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28883985/local-stakeholders-perceptions-of-community-sensitization-for-school-based-deworming-programme-in-kenya
#13
D W Njomo, J Masaku, F Mwende, G Odhiambo, R Musuva, E Matey, I G Thuita, J H Kihara
BACKGROUND: In Kenya, the National School-Based Deworming Programme (NSBDP) for soil-transmitted helminthes and schistosomiasis in prioritized areas has been going on since the year 2012. By the year 2013 over 6 million School Age Children (SAC) had been treated. A community sensitization supplement containing key messages and answers to frequently asked questions was developed as a guiding tool. Awareness creation methods used include county sensitization meetings, stakeholder forums, town criers and posters...
2017: Tropical Diseases, Travel Medicine and Vaccines
https://www.readbyqxmd.com/read/28879600/infections-and-the-kidney-a-tale-from-the-tropics
#14
Nivedita Kamath, Arpana Iyengar
Tropical infections are caused by a variety of bacteria, viruses and parasitic organisms across varying geographical regions and are more often reported in adults than in children. Most of the infections are acute, presenting as a febrile illness with involvement of multiple organ systems, including the kidney. The gamut of renal manifestations extends from asymptomatic urinary abnormalities to acute kidney injury and-albeit rarely-chronic kidney disease. Tropical infections can involve the glomerular, tubulointerstitial and vascular compartments of the kidney...
September 6, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28878432/ethiopia-schistosomiasis-and-soil-transmitted-helminthes-control-programme-progress-and-prospects
#15
Nebiyu Negussu, Birhan Mengistu, Biruck Kebede, Kebede Deribe, Ephrem Ejigu, Gemechu Tadesse, Kalkidan Mekete, Mesfin Sileshi
Schistosomiasis and soil-transmitted helminthes are among seventeen WHO prioritized neglected tropical diseases that infect humans. These parasitic infections can be treated using single-dose and safe drugs. Ethiopia successfully mapped the distribution of these infections nationwide. According to the mapping there are an estimated 37.3 million people living in schistosomiasis endemic areas, and 79 million in schistosomiasis and soil-transmitted helminthes endemic areas. The Federal Ministry of Health successfully scaled up Schistosomiasis and schistosomiasis and soil-transmitted helminthes intervention in endemic areas and treated over 19 million individuals in 2015...
2017: Ethiopian Medical Journal
https://www.readbyqxmd.com/read/28878427/mortality-and-disability-adjusted-life-years-dalys-for-common-neglected-tropical-diseases-in-ethiopia-1990-2015-evidence-from-the-global-burden-of-disease-study-2015
#16
A Deribew, B Kebede, G A Tessema, Y A Adama, A Misganaw, T Gebre, A Hailu, S Biadgilign, A Amberbir, B Desalegn, A A Abajobir, O Shafi, S F Abera, N Negussu, B Mengistu, A T Amare, A Mulugeta, Z Kebede, B Mengistu, Z Tadesse, M Sileshi, M Tamiru, E A Chromwel, S D Glenn, J D Stanaway, K Deribe
INTRODUCTION: Neglected tropical diseases (NTDs) are important public health problems in Ethiopia. In 2013, the Federal Ministry of Health (FMOH) has launched a national NTD master plan to eliminate major NTDs of public health importance by 2020. Benchmarking the current status of NTDs in the country is important to monitor and evaluate the progress in the implementation of interventions and their impacts. Therefore, this study aims to assess the trends of mortality and Disability-adjusted Life-Years (DALY) for the priority NTDs over the last 25 years...
2017: Ethiopian Medical Journal
https://www.readbyqxmd.com/read/28876652/unusual-histopathologies-of-the-appendix
#17
L Jonas, I Bombil, A Mannell
BACKGROUND: Acute appendicitis is a very common surgical emergency. Most commonly, the histopathological findings of the appendix reflect the normal pathophysiology of appendicitis that starts with the luminal obstruction and culminates in florid suppurative, gangrenous or perforated appendix. The treatment is usually straightforward and consists of surgery and antibiotics. Uncommonly, unusual pathologies are identified and require specific management. The literature is scanty about the unusual findings...
June 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28876430/thrombocytopenia-as-a-marker-of-liver-steatosis-in-a-low-endemic-area-for-schistosomiasis-mansoni
#18
Alba Otoni, Carlos Mauricio de Figueiredo Antunes, Fernanda Ferreira Tavares, Débora Heloísa Quadros Araújo, Thiago de Almeida Pereira, Leonardo Campos de Queiroz, Frederico Figueiredo Amâncio, José Roberto Lambertucci
Introduction: Thrombocytopenia is commonly found in patients living in highly endemic areas for Schistosoma mansoni. Recently, different degrees of liver steatosis have also been associated with low platelet counts worldwide. We investigated the association of platelet counts with hepatosplenic schistosomiasis and with liver steatosis in an area of low prevalence of schistosomiasis in Brazil. Method: Pains, a city in the state of Minas Gerais, Brazil, had a population of 8,307 inhabitants and a schistosomiasis prevalence of 8%...
June 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/28874839/the-schistosoma-mansoni-genome-encodes-thousands-of-long-non-coding-rnas-predicted-to-be-functional-at-different-parasite-life-cycle-stages
#19
Elton J R Vasconcelos, Lucas F daSilva, David S Pires, Guilherme M Lavezzo, Adriana S A Pereira, Murilo S Amaral, Sergio Verjovski-Almeida
Next Generation Sequencing (NGS) strategies, like RNA-Seq, have revealed the transcription of a wide variety of long non-coding RNAs (lncRNAs) in the genomes of several organisms. In the present work we assessed the lncRNAs complement of Schistosoma mansoni, the blood fluke that causes schistosomiasis, ranked among the most prevalent parasitic diseases worldwide. We focused on the long intergenic/intervening ncRNAs (lincRNAs), hidden within the large amount of information obtained through RNA-Seq in S. mansoni (88 libraries)...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28874579/nitric-oxide-blocks-the-development-of-the-human-parasite-schistosoma-japonicum
#20
Jia Shen, De-Hua Lai, R Alan Wilson, Yun-Fu Chen, Li-Fu Wang, Zi-Long Yu, Mei-Yu Li, Ping He, Geoff Hide, Xi Sun, Ting-Bao Yang, Zhong-Dao Wu, Francisco J Ayala, Zhao-Rong Lun
Human schistosomiasis, caused by Schistosoma species, is a major public health problem affecting more than 700 million people in 78 countries, with over 40 mammalian host reservoir species complicating the transmission ecosystem. The primary cause of morbidity is considered to be granulomas induced by fertilized eggs of schistosomes in the liver and intestines. Some host species, like rats (Rattus norvegicus), are naturally intolerant to Schistosoma japonicum infection, and do not produce granulomas or pose a threat to transmission, while others, like mice and hamsters, are highly susceptible...
September 5, 2017: Proceedings of the National Academy of Sciences of the United States of America
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