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https://www.readbyqxmd.com/read/29331607/solid-dispersions-to-enhance-the-delivery-of-a-potential-drug-candidate-lpsf-fz4-for-the-treatment-of-schistosomiasis
#1
Giovanna C R M Schver, Dajun D Sun, Salvana P M Costa, Keyla E R Silva, Jamerson F Oliveira, Larissa Araujo Rolim, Mônica Camelo Pessôa de Azevedo Albuquerque, André de Lima Aires, Maria do Carmo A Lima, Ivan R Pitta, Ping I Lee, Pedro J Rolim-Neto
Drug candidate LPSF/FZ4 with promising schistosomicidal properties in vitro was previously synthesized. However, LPSF/FZ4 has limited aqueous solubility (<1 μg/mL), leading to ineffective dissolution and, therefore, no meaningful in vivo comparative studies could be pursued. This study was aimed to develop a proper amorphous solid dispersion (SD) to enhance the solubility and dissolution rate of LPSF/FZ4 such that its biological activity could be investigated. To better understand its physiological behavior, the pKa of LPSF/FZ4, a monoprotic weak acid with NH group at the imidazolidine ring, was first determined to be 8...
January 10, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29331279/dynamics-of-spatiotemporal-distribution-of-schistosomiasis-in-hubei-province-china
#2
Yan-Yan Chen, Jian-Bing Liu, Yong Jiang, Guo Li, Xiao-Wei Shan, Juan Zhang, Shun-Xiang Cai, Xi-Bao Huang
Schistosomiasis caused by parasitic flatworms of blood flukes, remains a major public health concern in China. The significant progress in controlling schistosomiasis in China over the past decades has resulted in the remarkable reduction in the prevalence and intensity of Schistosoma japonicum infection to an extremely low level. Therefore, the elimination of schistosomiasis has been promoted by the Chinese national government. Hubei Province is the major endemic area, that is, along the middle and low reaches of the Yangtze River in the lake and marshland regions of southern China...
January 10, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29331278/impact-of-treatment-with-a-protein-tyrosine-kinase-inhibitor-genistein-on-acute-and-chronic-experimental-schistosoma-mansoni-infection
#3
Maysa Mohamed Kamel Sobhy, Soheir Sayed Mahmoud, Shaimaa Helmy El-Sayed, Enas Mohamed Ali Rizk, Amira Raafat, Mohamed Sherif Ismail Negm
Schistosomiasis mansoni is considered one of the most common fibrotic diseases resulting from inflammation and deposition of fibrous tissue around parasitic eggs trapped in the liver, causing morbidity and mortality. Chemotherapy against schistosomiasis is largely dependent on Praziquantel (PZQ). Yet, the huge administration of it in endemic areas and its incompetence towards the immature stages have raised serious alarms against the development of drug resistance. Few drugs are directed to reverse schistosomal liver fibrosis, particularly at the chronic and advanced stages of the disease...
January 10, 2018: Experimental Parasitology
https://www.readbyqxmd.com/read/29325068/emergence-of-non-falciparum-plasmodium-infection-despite-regular-artemisinin-combination-therapy-in-a-18-month-longitudinal-study-of-ugandan-children-and-their-mothers
#4
Martha Betson, Sarah Clifford, Michelle Stanton, Narcis B Kabatereine, J Russell Stothard
As part of a longitudinal cohort investigation of intestinal schistosomiasis and malaria in Ugandan children and their mothers on the shorelines of Lakes Victoria and Albert, we documented risk factors and morbidity associated with non-falciparum Plasmodium infections and the longitudinal dynamics of Plasmodium species in children. Host age, household location and P. falciparum infection were strongly associated with non-falciparum Plasmodium infections, and P. malariae infection was associated with splenomegaly...
January 6, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29323718/effect-of-mir-182-on-hepatic-fibrosis-induced-by-schistosomiasis-japonica-by-targeting-foxo1-through-pi3k-akt-signaling-pathway
#5
Yu Huang, Xiangxue Fan, Ran Tao, Qiqing Song, Likui Wang, Hongyue Zhang, Hongyan Kong, Jiaquan Huang
OBJECTIVE: The study aimed to investigate the impact of miR-182 and FOXO1 on S. japonica-induced hepatic fibrosis. METHODS: Microarray analysis was performed to screen out differential expressed miRNAs and mRNAs. Rat hepatic fibrosis model and human hepatocellular cell line LX-2 were used to study the effect of miR-182 and FOXO1. qRT-PCR and western blot were used to detect the expression of miR-182, FOXO1 or other fibrosis markers. The targeting relationship between FOXO1 and miR-182 was verified by luciferase reporter assay...
January 11, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29323093/urinary-schistosomiasis-schistosoma-haematobium-infection-diagnosed-by-histopathology
#6
Yung-Yao Lin, Victor Chia-Hsiang Lin, I-Wei Chang
No abstract text is available yet for this article.
October 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29319772/clinical-and-histological-features-of-patients-with-membranoproliferative-glomerulonephritis-classified-by-immunofluorescence-findings
#7
Cristiane Bitencourt Dias, Leonardo Testagrossa, Lectícia Jorge, Denise Malheiros, Viktoria Woronik
BACKGROUND: New classification for membranoproliferative glomerulonephritis has been proposed in the literature. The aim of this study was to compare the clinical, biochemical, etiology and renal biopsy findings of these patients grouped by immunofluorescence as proposed by the new classification. METHODS: Patients with renal biopsy-proven membranoproliferative glomerulonephritis unrelated to systemic lupus erythematosus, diagnosed between 1999 and 2014. The patients were divided according to immunofluorescence: Immunoglobulin positive group, C3 positive only and negative immunofluorescence group...
October 2017: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/29319763/current-distribution-pattern-of-biopsy-proven-glomerular-disease-in-salvador-brazil-40-years-after-an-initial-assessment
#8
Washington Luis Conrado Dos-Santos, Glória Maria Maranhão Sweet, Labene Gondim Azevêdo, Maria Brandão Tavares, Maria Fernanda Sanches Soares, Caroline Vilas Boas de Melo, Márcia Fernanda Melo Carneiro, Rilma Ferreira de Souza Santos, Márcia Cristina Conrado, Daniela Teixeira Leal Braga, Marcia Carvalho Bessa, Nathanael de Freitas Pinheiro Junior, Marília Bahiense-Oliveira
INTRODUCTION: A report on the prevalence of glomerular disease diagnosed via renal biopsy in Salvador, BA, Brazil was published in 1973 and showed a predominance of membranoproliferative glomerulonephritis, which was frequently associated with hepatosplenic schistosomiasis. OBJECTIVE: In this study, we investigate the potential changes in the distribution of glomerular diseases after a period of important epidemiological transition in Brazil. METHODS: Pathology reports of all patients subjected to kidney biopsy from 2003 to 2015 in a referral nephrology service were reviewed...
October 2017: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/29318998/travel-related-parasitic-infections-in-travellers-to-southeast-asia-and-western-pacific-countries
#9
Eylem Akdur Öztürk, Ayşegül Ünver
In the last decades, there has been a significant increase in international human mobility with increase in the prosperity, travel possibilities, and number of refugees. In the first half of 2016, the Asian continent showed the fastest growth in the number of tourists. Such increase is seen due to the interest in Asian history, culture, and cuisine. In the globalizing world, human mobility causes changes in the epidemiology of diseases and the spread of various infections across continents. Parasitic infections that may pose a risk for travellers to the Asia-Pacific are malaria, leishmaniasis, filariasis, foodborne trematode infections, schistosomiasis, soil-transmitted infections, and tourist diarrhea...
December 2017: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/29318713/hybrid-feature-extraction-techniques-for-microscopic-hepatic-fibrosis-classification
#10
Dalia S Ashour, Dina M Abou Rayia, Mohamed Maher Ata, Amira S Ashour, Mustafa M Abd Elnaby
Chronic liver diseases' hallmark is the fibrosis that results in liver function failure in advanced stages. One of the serious parasitic diseases affecting the liver tissues is schistosomiasis. Immunologic reactions to Schistosoma eggs leads to accumulation of collagen in the hepatic parenchyma causing fibrosis. Thus, monitoring and reporting the staging of the histopathological information related to liver fibrosis are essential for accurate diagnosis and therapy of the chronic liver diseases. Automated assessment of the microscopic liver tissue images is an essential process...
January 10, 2018: Microscopy Research and Technique
https://www.readbyqxmd.com/read/29317884/evaluation-of-the-anti-schistosomal-effects-of-turmeric-curcuma-longa-versus-praziquantel-in-schistosoma-mansoni-infected-mice
#11
Atef Hussein, Samia Rashed, Ibrahim El Hayawan, Rabab El-Sayed, Hemat Ali
Background: Curcumin is the major active ingredient of Curcuma longa L., traditionally known as turmeric and has been shown to exhibit a wide range of pharmacological activities including anti-parasitic effect. However, it is found to be water-insoluble and has low bioavailability. The aim of this study was to explore the potential role of turmeric solved in olive oil either alone or in combination with praziquantel (PZQ) in treatment of schistosomiasis mansoni. Methods: The whole turmeric powder suspended in olive oil (as a solvent) is indicated to S...
October 2017: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/29317853/real-time-observation-of-pathophysiological-processes-during-murine-experimental-schistosoma-japonicum-infection-using-high-resolution-ultrasound-imaging
#12
Katsumi Maezawa, Rieko Furushima-Shimogawara, Akio Yasukawa, Nobuo Ohta, Shiro Iwanaga
Background: Hepatosplenic lesion formation is one of the typical clinical symptoms of schistosomiasis japonica. Although it is established that circum-oval granuloma formation mediated by T lymphocytes is the key event triggering the formation of hepatic lesions, the time-course kinetics of disease progression remains to be fully elucidated. Methods: The real-time process of the pathophysiology of schistosomiasis japonica from the early to late clinical phase was non-invasively observed in a murine experimental infection model using high-resolution ultrasonography...
2018: Tropical Medicine and Health
https://www.readbyqxmd.com/read/29316983/urogenital-schistosomiasis-in-cabo-delgado-northern-mozambique-baseline-findings-from-the-score-study
#13
Anna E Phillips, Pedro H Gazzinelli-Guimarães, Herminio O Aurelio, Neerav Dhanani, Josefo Ferro, Rassul Nala, Arminder Deol, Alan Fenwick
BACKGROUND: The results presented here are part of a five-year cluster-randomised intervention trial that was implemented to understand how best to gain and sustain control of schistosomiasis through different preventive chemotherapy strategies. This paper presents baseline data that were collected in ten districts of Cabo Delgado province, northern Mozambique, before treatment. METHODS: A cross-sectional study of 19,039 individuals was sampled from 144 villages from May to September 2011...
January 10, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29313478/schistosomiasis-and-infertility-in-east-africa
#14
Patricia A Woodall, Michael R Kramer
Case reports and pathology series suggest associations of female genital schistosomiasis (Schistosoma haematobium) with infertility and ectopic pregnancy. Differential geographic distribution of infertility is not explained by analyses of known risk factors. In this cross-sectional multilevel semi-ecologic study, interpolated prevalence maps for S. haematobium and Schistosoma mansoni in East Africa were created using data from two open-access Neglected Tropical Diseases Databases. Prevalence was extracted to georeferenced survey sample points for Demographic and Health Surveys for Ethiopia, Kenya, Tanzania, and Uganda for 2000 and 2010...
January 8, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29313262/structural-elucidation-of-poloxamer-237-and-poloxamer-237-praziquantel-solid-dispersions-impact-of-poly-vinylpyrrolidone-over-drug-recrystallization-and-dissolution
#15
Silvina Orlandi, Josefina Priotti, Hermínio P Diogo, Dario Leonardi, Claudio J Salomon, Teresa G Nunes
Praziquantel (PZQ) is the recommended, effective, and safe treatment against all forms of schistosomiasis. Solid dispersions (SDs) in water-soluble polymers have been reported to increase solubility and bioavailability of poorly water-soluble drugs like PZQ, generally due to the amorphous form stabilization. In this work, poloxamer (PLX) 237 and poly(vinylpyrrolidone) (PVP) K30 were evaluated as potential carriers to revert PZQ crystallization. Binary and ternary SDs were prepared by the solvent evaporation method...
January 8, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29310695/understanding-the-relationship-between-egg-and-antigen-based-diagnostics-of-schistosoma-mansoni-infection-pre-and-post-treatment-in-uganda
#16
Joaquín M Prada, Panayiota Touloupou, Moses Adriko, Edridah M Tukahebwa, Poppy H L Lamberton, T Déirdre Hollingsworth
BACKGROUND: Schistosomiasis is a major socio-economic and public health problem in many sub-Saharan African countries. After large mass drug administration (MDA) campaigns, prevalence of infection rapidly returns to pre-treatment levels. The traditional egg-based diagnostic for schistosome infections, Kato-Katz, is being substituted in many settings by circulating antigen recognition-based diagnostics, usually the point-of-care circulating cathodic antigen test (CCA). The relationship between these diagnostics is poorly understood, particularly after treatment in both drug-efficacy studies and routine monitoring...
January 8, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29309743/population-based-and-animal-study-on-the-effects-of-schistosoma-japonicum-infection-in-the-regulation-of-host-glucose-homeostasis
#17
Qiong Duan, Lu Xiong, Chaonan Liao, Zhenzhen Liu, Yi Xiao, Ruixue Huang, Ting Tan, Yanhao Ouyang, Jinxing Cai, Meifang Xiao, Huilan Xu, Zihua Chen, Lizhang Chen, Tianlun Yang, He Huang
Although parasitic infection affects the glucose homeostasis of mice, only few studies have integrated epidemiological and animal data to determine the effect of Schistosoma japonicum infection on mice metabolism. The current study assessed the effects of S. japonicum infection on blood glucose and other metabolic parameters in both patients and animal models of chronic schistomiasis. A total of 2,183 patients with chronic schistosomiasis and age- and gender-matched individuals without schistosomiasis (n = 1,798) were enrolled in this study...
January 5, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29305986/biological-activities-and-functional-analysis-of-macrophage-migration-inhibitory-factor-in-oncomelania-hupensis-the-intermediate-host-of-schistosoma-japonicum
#18
Shuaiqin Huang, Theerakamol Pengsakul, Yunchao Cao, Mingke Lu, Wenfeng Peng, Jiaojiao Lin, Chongti Tang, Liang Tang
Schistosomiasis is a destructive parasitic zoonosis caused by agents of the genus Schistosoma, which afflicts more than 250 million people worldwide. The freshwater amphibious snail Oncomelania hupensis serves as the obligate intermediate host of Schistosoma japonicum. Macrophage migration inhibitory factor (MIF) has been demonstrated to be a pleiotropic immunoregulatory cytokine and a key signaling molecule involved in adaptive and innate immunity. In the present study, we obtained the full-length cDNA of OhMIF and analyzed the characteristics of the ORF and the peptide sequence in O...
January 3, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29301964/impact-and-cost-effectiveness-of-snail-control-to-achieve-disease-control-targets-for-schistosomiasis
#19
Nathan C Lo, David Gurarie, Nara Yoon, Jean T Coulibaly, Eran Bendavid, Jason R Andrews, Charles H King
Schistosomiasis is a parasitic disease that affects over 240 million people globally. To improve population-level disease control, there is growing interest in adding chemical-based snail control interventions to interrupt the lifecycle of Schistosoma in its snail host to reduce parasite transmission. However, this approach is not widely implemented, and given environmental concerns, the optimal conditions for when snail control is appropriate are unclear. We assessed the potential impact and cost-effectiveness of various snail control strategies...
January 4, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29295718/systematic-review-and-meta-analysis-on-schistosoma-mansoni-infection-prevalence-and-associated-risk-factors-in-brazil
#20
Maria Teresinha Gomes Casavechia, Gessilda de Alcântara Nogueira de Melo, Andrea Claudia Bekner Da Silva Fernandes, Karin Reinhold De Castro, Raissa Bocchi Pedroso, Thaís Da Silva Santos, Jorge Juarez Vieira Teixeira
We performed a systematic review and meta-analysis on the prevalence and factors associated with Schistosoma mansoni infection in Brazil. We searched the PubMed, Web of Science and Latin-American and Caribbean System on Health Sciences Information (LILACS) databases, scientific publications articles, according to The PRISMA Statement, from 2000 to 2016. A total of 27 studies were included according to the established criteria. The prevalence of S. mansoni infection varied widely, from 0·1 to 73·1%, based on Kato-Katz technique...
January 3, 2018: Parasitology
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