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https://www.readbyqxmd.com/read/27907208/interaction-between-salmonella-and-schistosomiasis-a-review
#1
REVIEW
Amber Hsiao, Trevor Toy, Hye Jin Seo, Florian Marks
The interaction between schistosomiasis and Salmonella is a particularly important issue in Africa, where dual infection by the parasite and the bacterium are likely common. In this review, the ways in which schistosomiasis affects human biology as it relates to Salmonella are described. Those who are infected by both organisms experience reduced immunological functioning, exhibit irreversible organ damage due to prolonged schistosomiasis infection, and become latent carriers of Salmonella enterica serotypes Typhi and Paratyphi and S...
December 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27905117/pharmacokinetics-of-new-high-concentration-and-long-acting-praziquantel-oily-suspensions-after-intramuscular-administration-in-cattle
#2
M Qian, L Wei, L Hao, S Tang
The aim of the study was to develop praziquantel (PZQ) oily suspensions with 30% PZQ high concentration for intramuscular injection and investigate their pharmacokinetics in cattle. Two optimized formulations containing 30% PZQ were developed in this study, and their quality met the technical standards set by the Ministry of Agriculture of the People's Republic of China. After intramuscular administrations of the suspensions (30 mg/kg), no significant differences were observed between the two oily suspensions...
December 1, 2016: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27903313/robert-leiper-and-the-london-school-of-hygiene-and-tropical-medicine
#3
Francis E G Cox
Robert Leiper is best known for his discoveries in the fields of Guinea worm and schistosomiasis, but he also made major contributions to parasitology during his career as helminthologist and later Professor of Helminthology at the London School of (Hygiene and) Tropical Medicine. He was particularly involved in establishing the London School's Winches Farm Field Station and stimulating the research carried out there, work that has made a number of important contributions to our understanding of parasites. Leiper founded the Commonwealth Bureau of Agricultural Parasitology and was also instrumental in initiating, and editing, the Journal of Helminthology, Helminthological Abstracts and establishing, indirectly, Protozoological Abstracts...
December 1, 2016: Parasitology
https://www.readbyqxmd.com/read/27903067/predicting-the-spatial-distribution-of-biomphalaria-straminea-a-potential-intermediate-host-for-schistosoma-mansoni-in-china
#4
Mohamed R Habib, Yun-Hai Guo, Shan Lv, Wen-Biao Gu, Xiao-Heng Li, Xiao-Nong Zhou
Schistosomiasis is one of the most prevalent parasitic diseases impacting human health in the tropics and sub-tropics. The geographic distribution of Schistosoma mansoni, the most widespread species, includes areas in Africa, the Middle East, South America and the Caribbean. Snails of the genus Biomphalaria act as intermediate host for S. mansoni. Biomphalaria straminea is not indigenous in China but was accidentally introduced to Hong Kong from South America and has spread to other habitats in the southern parts of the country...
November 29, 2016: Geospatial Health
https://www.readbyqxmd.com/read/27903066/the-spatio-temporal-distribution-of-oncomelania-hupensis-along-yangtze-river-in-jiangsu-province-china-after-implementation-of-a-new-integrated-schistosomiasis-control-strategy
#5
Jian He, Wei Li, Robert Bergquist, Jian-Feng Zhang, Liang Shi, Song Zhao, Feng Wu, Kun Yang
This study concerns an integrated strategy of schistosomiasis control, focusing on the management and elimination of the main transmission cycles and reservoirs along Yangtze river, Jiangsu Province (China), instituted in 2004. Our analysis, including mapping, spatial autocorrelation and spatio-temporal scanning, was implemented between 2001 and 2013 to explore the changes in the distribution of Oncomelania hupensis, the intermediate host of Schistosoma japonicum. Two high-density snail locations in the upper and middle reaches of the river were observed along with one high-risk area due to infected snails in the upper reaches at the beginning of the study period...
November 29, 2016: Geospatial Health
https://www.readbyqxmd.com/read/27903064/modelling-of-the-distribution-of-biomphalaria-glabrata-and-biomphalaria-straminea-in-the-metropolitan-region-of-recife-pernambuco-brazil
#6
Verônica Santos Barbosa, Ricardo José de Paula Souza E Guimarães, Rodrigo Moraes Loyo, Constança Simões Barbosa
The occurrence of schistosomiasis is directly linked to the presence of its snail intermediate host Biomphalaria spp. Knowledge of geographical distribution, habitats and behaviour of these snails in relation to the climate is essential for guiding measures for disease prevention and control. This study aims to model the distribution of B. glabrata and B. straminea in schistosomiasis non-endemic areas of the metropolitan region of Recife (MRR) based on environmental data and estimates of snail distributions in endemic and neighbouring areas...
November 25, 2016: Geospatial Health
https://www.readbyqxmd.com/read/27896890/diterpenes-as-lead-molecules-against-neglected-tropical-diseases
#7
REVIEW
Marcus Vinícius Oliveira Barros de Alencar, João Marcelo de Castro E Sousa, Hercília Maria Lins Rolim, Maria das Graças Freire de Medeiros, Gilberto Santos Cerqueira, Fernanda Regina de Castro Almeida, Antônia Maria das Graças Lopes Citó, Paulo Michel Pinheiro Ferreira, José Arimatéia Dantas Lopes, Ana Amélia de Carvalho Melo-Cavalcante, Md Torequl Islam
Nowadays, neglected tropical diseases (NTDs) are reported to be present everywhere. Poor and developing areas in the world have received great attention to NTDs. Drug resistance, safety profile, and various challenges stimulate the search for alternative medications. Plant-based drugs are viewed with great interest, as they are believed to be devoid of side effects. Diterpenes, a family of essential oils, have showed attractive biological effects. A systematic review of the literature was carried out to summarize available evidences of diterpenes against NTDs...
November 29, 2016: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/27895916/mechanically-produced-schistosomula-as-a-higher-throughput-tools-for-phenotypic-pre-screening-in-drug-sensitivity-assays-current-research-and-future-trends
#8
REVIEW
Emmanuel Mouafo Tekwu, William Kofi Anyan, Daniel Boamah, Kofi Owusu Baffour-Awuah, Stephanie Keyetat Tekwu, Veronique Penlap Beng, Alexander Kwadwo Nyarko, Kwabena Mante Bosompem
It is crucial to develop new antischistosomal drugs since there is no vaccine and the whole world is relying on only a single drug for the treatment of schistosomiasis. One of the obstacles to the development of drugs is the absence of the high throughput objective screening methods to assess drug compounds efficacy. Thus for identification of new drug compounds candidates, fast and accurate in vitro assays are unavoidable and more research efforts in the field of drug discovery can target schistosomula. This review presents a substantial overview of the present state of in vitro drug sensitivity assays developed so far for the determination of anti-schistosomula activity of drug compounds, natural products and derivatives using newly transformed schistosomula (NTS)...
2016: Biomarker Research
https://www.readbyqxmd.com/read/27891322/epigenetics-in-schistosomes-what-we-know-and-what-we-need-know
#9
REVIEW
Weiwei Liu
Schistosomes are metazoan parasites and can cause schistosomiasis. Epigenetic modifications include DNA methylation, histone modifications and non-coding RNAs. Some enzymes involved in epigenetic modification and microRNA processes have been developed as drugs to treat the disease. Compared with humans and vertebrates, an in-depth understanding of epigenetic modifications in schistosomes is starting to be realized. DNA methylation, histone modifications and non-coding RNAs play important roles in the development and reproduction of schistosomes and in interactions between the host and schistosomes...
2016: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/27888125/initiating-ntd-programs-targeting-schistosomiasis-and-soil-transmitted-helminthiasis-in-two-provinces-of-the-democratic-republic-of-the-congo-establishment-of-baseline-prevalence-for-mass-drug-administration
#10
Achille Kabore, Moudachirou Ibikounle, Jean Jacques Tougoue, Sylvain Mupoyi, Martin Ndombe, Scott Shannon, Eric A Ottesen, Faustin Mukunda, Naomi Awaca
BACKGROUND: Schistosomiasis (SCH) and soil-transmitted helminthiasis (STH) are widely distributed in the Democratic Republic of the Congo (DRC) and constitute a serious public health problem. As recommended by the World Health Organization (WHO), before launching mass chemotherapy to control these diseases, parasitological surveys were conducted in sentinel sites in six health zones (HZs) in Bandundu and Maniema provinces. Baseline prevalence and intensity of infection for SCH and STH were determined to establish the appropriate treatment plan using Praziquantel (PZQ) and Albendazole (ALB)...
November 22, 2016: Acta Tropica
https://www.readbyqxmd.com/read/27885149/yoshitaka-komiya-s-visits-to-china-and-schistosomiasis-investigation
#11
Ka-Wai Fan
This article is about a Japanese parasitologist, Yoshitaka Komiya (1900-1976), who was invited to China for a schistosomiasis investigation in 1956. In 1955, Chairman Mao initiated a national campaign to eliminate schistosomiasis, which at that time was still common in southern China, and for this purpose, the People's Republic of China invited Yoshitaka Komiya to China. He published a report based on his observations during this visit. This article aims to explore the meaning of Komiya's visit to the People's Republic of China and his observations about the anti-schistosomiasis campaign...
November 24, 2016: Journal of Medical Biography
https://www.readbyqxmd.com/read/27884406/-clinical-approach-to-imported-eosinophilia
#12
Elías Cañas García-Otero, Julia Praena-Segovia, Maite Ruiz-Pérez de Pipaón, Xerach Bosh-Guerra, Magdalena Sánchez-Agüera, Daniel Álvarez-Martínez, José Miguel Cisneros-Herreros
Eosinophilia is a common finding in international travelers and immigrants, being an helmintic infection its main etiology. The positive predictive value of eosinophilia for an helmintosis is low in travellers. Eosinophilia may be an incidental finding, or symptomatic, and it represents a clinical challenge due to the low sensitivity and specificity of direct and indirect parasitological diagnostic tests, respectively. It requires a structured approach based on geographical areas, environmental exposures and behavioral risks, and associated symptoms...
November 21, 2016: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/27884378/purinergic-signaling-in-schistosomal-infection
#13
REVIEW
Claudia Lucia Martins Silva
Human schistosomiasis is a chronic inflammatory disease caused by blood fluke worms belonging to the genus Schistosoma. Health metrics indicate that the disease is related to an elevated number of years lost-to-disability and years lost-to-life. Schistosomiasis is an intravascular disease that is related to a Th1 and Th2 immune response polarization, and the degree of polarization affects the outcome of the disease. The purinergic system is composed of adenosine and nucleotides acting as key messenger molecules...
October 2016: Biomedical Journal
https://www.readbyqxmd.com/read/27884376/purinergic-signaling-in-infection-and-autoimmune-disease
#14
EDITORIAL
Luiz Eduardo Baggio Savio, Robson Coutinho-Silva
Purinergic signaling plays a key role in inflammatory processes and modulates immune responses against a variety of bacterial and eukaryotic parasites. Here we highlight the role of purinergic receptor activation in infection and autoimmune diseases. Purinergic signaling and inflammasomes modulate the host immune response against chlamydial infections. In addition, increasing evidence suggests that purinergic signaling contributes to Schistosomiasis morbidity, a neglected tropical disease caused by parasitic worms called schistosomes...
October 2016: Biomedical Journal
https://www.readbyqxmd.com/read/27882478/unexpected-hosts-imaging-parasitic-diseases
#15
REVIEW
Pablo Rodríguez Carnero, Paula Hernández Mateo, Susana Martín-Garre, Ángela García Pérez, Lourdes Del Campo
Radiologists seldom encounter parasitic diseases in their daily practice in most of Europe, although the incidence of these diseases is increasing due to migration and tourism from/to endemic areas. Moreover, some parasitic diseases are still endemic in certain European regions, and immunocompromised individuals also pose a higher risk of developing these conditions. This article reviews and summarises the imaging findings of some of the most important and frequent human parasitic diseases, including information about the parasite's life cycle, pathophysiology, clinical findings, diagnosis, and treatment...
November 23, 2016: Insights Into Imaging
https://www.readbyqxmd.com/read/27880808/natural-schistosoma-mansoni-infection-in-the-wild-reservoir-nectomys-squamipes-leads-to-excessive-lipid-droplet-accumulation-in-hepatocytes-in-the-absence-of-liver-functional-impairment
#16
Kátia B Amaral, Thiago P Silva, Kássia K Malta, Lívia A S Carmo, Felipe F Dias, Mariana R Almeida, Gustavo F S Andrade, Jefferson S Martins, Roberto R Pinho, Sócrates F Costa-Neto, Rosana Gentile, Rossana C N Melo
Schistosomiasis is a neglected tropical disease of a significant public health impact. The water rat Nectomys squamipes is one of the most important non-human hosts in the schistosomiasis mansoni transmission in Brazil, being considered a wild reservoir. Cellular mechanisms that contribute to the physiological adaptation of this rodent to the Schistosoma mansoni parasite are poorly understood. Here we identified, for the first time, that a hepatic steatosis, a condition characterized by excessive lipid accumulation with formation of lipid droplets (LDs) within hepatocytes, occurs in response to the natural S...
2016: PloS One
https://www.readbyqxmd.com/read/27879105/optimal-control-analysis-of-malaria-schistosomiasis-co-infection-dynamics
#17
Kazeem Oare Okosun, Robert Smith
This paper presents a mathematical model for malaria--schistosomiasis co-infection in order to investigate their synergistic relationship in the presence of treatment. We first analyse the single infection steady states, then investigate the existence and stability of equilibria and then calculate the basic reproduction numbers. Both the single-infection models and the co-infection model exhibit backward bifurcations. We carrying out a sensitivity analysis of the co-infection model and show that schistosomiasis infection may not be associated with an increased risk of malaria...
April 1, 2017: Mathematical Biosciences and Engineering: MBE
https://www.readbyqxmd.com/read/27876913/circulating-cathodic-antigen-cassette-test-versus-haematuria-strip-test-in-diagnosis-of-urinary-schistosomiasis
#18
Azza S El-Ghareeb, Ghada S Abd El Motaleb, Nevien Maher Waked, Nancy Osman Hany Kamel, Nagwa Shaban Aly
Urinary schistosomiasis caused by Schistosoma haematobium constitutes a major public health problem in many tropical and sub-tropical countries. This study was conducted to evaluate circulating cathodic antigen cassette test and haematuria strip test for detection of S. haematobium in urine samples and to evaluate their screening performance among the study population. Microscopy was used as a gold standard. A total of 600 urine samples were examined by microscopy for detection of S. haematobium eggs, screened for microhaematuria using Self-Stik reagent strips and screened for circulating cathodic antigen (CCA) using the urine-CCA cassette test...
December 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/27876076/bladder-outlet-obstruction-a-rare-complication-of-the-neglected-schistosome-schistosoma-haematobium-two-case-reports-and-public-health-challenges
#19
Valirie Ndip Agbor, Tsi Njim, Franklin Ngu Mbolingong
BACKGROUND: Schistosomiasis is a severe parasitic infestation with debilitating complications and is the third most devastating tropical disease in the world. It is one of the neglected tropical diseases (NTDs) with a high disease-burden. We present two rare cases of bladder outlet obstruction: one which led to a chronic kidney disease and ultimately death and a second which recovered after treatment with praziquantel. CASE PRESENTATIONS: A 72 year old male presented with lower urinary tract symptoms which culminated in an episode of acute urinary retention...
November 22, 2016: BMC Research Notes
https://www.readbyqxmd.com/read/27875991/the-prevalence-of-renal-impairment-in-individuals-seeking-hiv-testing-in-urban-malawi
#20
Nicola Glaser, Sam Phiri, Tom Bruckner, Dominic Nsona, Hannock Tweya, Nomeda Ahrenshop, Florian Neuhann
BACKGROUND: Chronic kidney disease (CKD) poses a major health threat to people living in low- and middle-income countries, especially when it is combined with HIV, antiretroviral treatment (ART) or communicable and non-communicable diseases. Data about the prevalence of CKD and its association with other diseases is scarce, particularly in HIV-negative individuals. This study estimated the prevalence of CKD in individuals who were either HIV-positive (and ART-naïve) or HIV-negative in an urban Malawian population...
November 22, 2016: BMC Nephrology
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