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schistosomiasis

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https://www.readbyqxmd.com/read/28735972/pyrimidine-metabolism-in-schistosomes-a-comparison-with-other-parasites-and-the-search-for-potential-chemotherapeutic-targets
#1
REVIEW
Mahmoud H El Kouni
Schistosomes are responsible for the parasitic disease schistosomiasis, an acute and chronic parasitic ailment that affects more than 240 million people in 70 countries worldwide. It is the second most devastating parasitic disease after malaria. At least 200,000 deaths per year are associated with the disease. In the absence of the availability of vaccines, chemotherapy is the main stay for combating schistosomiasis. The antischistosomal arsenal is currently limited to a single drug, Praziquantel, which is quite effective with a single-day treatment and virtually no host-toxicity...
July 20, 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/28734515/the-global-state-of-helminth-control-and-elimination-in-children
#2
REVIEW
Jill E Weatherhead, Peter J Hotez, Rojelio Mejia
Helminth infections, including soil-transmitted helminths and schistosomiasis, remain one of the most common infections in the world with over 1 billion people infected. These infections cause significant morbidity, particularly in young children, that may last a lifetime, including growth and cognitive stunting. There is an urgent need for the control and elimination of helminth infections from areas of poverty to reduce morbidity in children. Mass drug administration programs were adopted by the World Health Assembly in 2001 and have evolved to provide coverage with multiple anthelmintic medications in a single rapid impact package and more extensive coverage within a community...
August 2017: Pediatric Clinics of North America
https://www.readbyqxmd.com/read/28733024/ecohealth-research-in-africa-where-from-where-to
#3
EDITORIAL
Robert Bergquist, Norbert W Brattig, Moses J Chimbari, Jakob Zinsstag, Jürg Utzinger
Epidemiological mapping and risk profiling build on the idea that diseases are tied to social-ecological systems that govern the distribution and abundance of transmissible pathogens, vectors and hosts. This is the heart of the emerging field of ecohealth, which examines how biological, cultural, demographic, economic, physical, political and social environments change can affect the health and wellbeing of humans, animals and ecosystems and the services they provide. This paper is an overview of a special issue of Acta Tropica, whose 15 publications reflect a geographically and epidemiologically diverse landscape of ecohealth in Africa...
July 18, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28722637/schistosomiasis-in-european-travelers-and-migrants-analysis-of-14-years-tropnet-surveillance-data
#4
Tilman Lingscheid, Florian Kurth, Jan Clerinx, Stefania Marocco, Begoña Trevino, Mirjam Schunk, José Muñoz, Ida E Gjørup, Tomas Jelinek, Michel Develoux, Graham Fry, Thomas Jänisch, Matthias L Schmid, Olivier Bouchaud, Sabino Puente, Lorenzo Zammarchi, Kristine Mørch, Anders Björkman, Heli Siikamäki, Andreas Neumayr, Henrik Nielsen, Urban Hellgren, Malgorzata Paul, Guido Calleri, Pavel Kosina, Bjørn Myrvang, José M Ramos, Gudrun Just-Nübling, Anna Beltrame, José Saraiva da Cunha, Peter Kern, Laurence Rochat, August Stich, Peter Pongratz, Martin P Grobusch, Norbert Suttorp, Martin Witzenrath, Christoph Hatz, Thomas Zoller, TropNet Schistosomiasis Investigator Group
Schistosomiasis remains one of the most prevalent parasitic diseases worldwide and the infection is frequently found in travelers and migrants. The European Network for Tropical Medicine and Travel Health conducted a sentinel surveillance study on imported schistosomiasis between 1997 and 2010. This report summarizes epidemiological and clinical data from 1,465 cases of imported schistosomiasis. Direct pathogen detection and serology were the main diagnostic tools applied. Of these, 486 (33%) cases were identified among European travelers, 231 (16%) among long-term expatriates, and 748 (51%) among non-European immigrants...
May 30, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28719649/differential-expression-of-small-rna-pathway-genes-associated-with-the-biomphalaria-glabrata-schistosoma-mansoni-interaction
#5
Fábio Ribeiro Queiroz, Luciana Maria Silva, Wander de Jesus Jeremias, Élio Hideo Babá, Roberta Lima Caldeira, Paulo Marcos Zech Coelho, Matheus de Souza Gomes
The World Health Organization (WHO) estimates that approximately 240 million people in 78 countries require treatment for schistosomiasis, an endemic disease caused by trematodes of the genus Schistosoma. In Brazil, Schistosoma mansoni is the only species representative of the genus whose passage through an invertebrate host, snails of the genus Biomphalaria, is obligatory before infecting a mammalian host, including humans. The availability of the genome and transcriptome of B. glabrata makes studying the regulation of gene expression, particularly the regulation of miRNA and piRNA processing pathway genes, possible...
2017: PloS One
https://www.readbyqxmd.com/read/28719280/multiplex-serologic-assessment-of-schistosomiasis-in-western-kenya-antibody-responses-in-preschool-aged-children-as-a-measure-of-reduced-transmission
#6
Kimberly Y Won, Henry M Kanyi, Faith M Mwende, Ryan E Wiegand, E Brook Goodhew, Jeffrey W Priest, Yeuk-Mui Lee, Sammy M Njenga, W Evan Secor, Patrick J Lammie, Maurice R Odiere
AbstractCurrently, impact of schistosomiasis control programs in Schistosoma mansoni-endemic areas is monitored primarily by assessment of parasitologic indicators only. Our study was conducted to evaluate the use of antibody responses as a way to measure the impact of schistosomiasis control programs. A total of 3,612 serum samples collected at three time points from children 1-5 years of age were tested for antibody responses to two schistosome antigens (soluble egg antigen [SEA] and Sm25) by multiplex bead assay...
June 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28713432/haematological-profile-and-intensity-of-urogenital-schistosomiasis-in-ghanaian-children
#7
Justice Afrifa, Desmond Gyedu, Eric Ofori Gyamerah, Samuel Essien-Baidoo, Isaac Mensah-Essilfie
BACKGROUND: Urogenital schistosomiasis is a widely contracted parasitic helminth infection often associated with haematological abnormalities. AIM: We investigated the relationship between the haematological profile and the intensity of schistosomiasis among children in the Yeji district. MATERIALS AND METHODS: A total of 100 participants comprising 50 Schistosoma haematobium (S. haematobium) infected and 50 noninfected controls aged 6-17 years matched for age and sex were recruited into the study...
2017: Journal of Environmental and Public Health
https://www.readbyqxmd.com/read/28708450/a-comparison-of-kenyan-biomphalaria-pfeifferi-and-b-sudanica-as-vectors-for-schistosoma-mansoni-including-a-discussion-of-the-need-to-better-understand-the-effects-of-snail-breeding-systems-on-transmission
#8
Martin Mutuku, Lijun Lu, Fredrick Otiato, Ibrahim Ndungu Mwangi, Joseph Mutonga Kinuthia, Geoffrey Murai Maina, Martina Rose Laidemitt, Eric Agola Lelo, Horace Ochanda, Eric Samuel Loker, Gerald Mwandori Mkoji
In Kenya, schistosomes infect an estimated 6 million people with >30 million people at risk of infection. We compared compatibility with, and ability to support and perpetuate, Schistosoma mansoni of Biomphalaria pfeifferi and Biomphalaria sudanica, 2 prominent freshwater snail species involved in schistosomiasis transmission in Kenya. Field-derived B. pfeifferi (from a stream in Mwea, central Kenya) and B. sudanica (from Nawa, Lake Victoria, in western Kenya) were exposed to S. mansoni miracidia isolated from fecal samples of naturally infected humans from Mwea or Nawa...
July 14, 2017: Journal of Parasitology
https://www.readbyqxmd.com/read/28704396/phenotypic-chemical-and-functional-characterization-of-cyclic-nucleotide-phosphodiesterase-4-pde4-as-a-potential-anthelmintic-drug-target
#9
Thavy Long, Liliana Rojo-Arreola, Da Shi, Nelly El-Sakkary, Kurt Jarnagin, Fernando Rock, Maliwan Meewan, Alberto A Rascón, Lin Lin, Katherine A Cunningham, George A Lemieux, Larissa Podust, Ruben Abagyan, Kaveh Ashrafi, James H McKerrow, Conor R Caffrey
BACKGROUND: Reliance on just one drug to treat the prevalent tropical disease, schistosomiasis, spurs the search for new drugs and drug targets. Inhibitors of human cyclic nucleotide phosphodiesterases (huPDEs), including PDE4, are under development as novel drugs to treat a range of chronic indications including asthma, chronic obstructive pulmonary disease and Alzheimer's disease. One class of huPDE4 inhibitors that have yielded marketed drugs is the benzoxaboroles (Anacor Pharmaceuticals)...
July 13, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28701752/suppression-of-vamp2-alters-morphology-of-the-tegument-and-affects-glucose-uptake-development-and-reproduction-of-schistosoma-japonicum
#10
Qian Han, Bingguang Jia, Yang Hong, Xiaodan Cao, Qi Zhai, Ke Lu, Hao Li, Chuangang Zhu, Zhiqiang Fu, Yonghong Shi, Jiaojiao Lin
Schistosomiasis caused by schsitosomes is a serious global public health concern. The tegument that surrounds the worm is critical to the schistosomes survival. The tegument apical membrane undergoes a continuous process of rupture and repair owing to membranous vacuoles fusing with the plasma membrane. Vesicle-associated membrane protein 2 (VAMP2), a member of soluble N-ethylmaleimide sensitive factor attachment protein receptor (SNAREs) is required for membrane fusion. Here, we used RNA interference (RNAi) to knock down the expression of VAMP2 of Schistosoma japonicum (SjVAMP2), and both real-time PCR and western blot analysis confirmed the suppression of this molecule, as well as the suppression of the transcript levels of schistosome glucose transporters (SGTP1 and SGTP4), and insulin receptors (SjIR1 and SjIR2)...
July 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28700640/modeling-the-risk-of-transmission-of-schistosomiasis-in-akure-north-local-government-area-of-ondo-state-nigeria-using-satellite-derived-environmental-data
#11
Oluwaremilekun G Ajakaye, Oluwatola I Adedeji, Paul O Ajayi
Schistosomiasis is a parasitic disease and its distribution, in space and time, can be influenced by environmental factors such as rivers, elevation, slope, land surface temperature, land use/cover and rainfall. The aim of this study is to identify the areas with suitable conditions for schistosomiasis transmission on the basis of physical and environmental factors derived from satellite imagery and spatial analysis for Akure North Local Government Area (LGA) of Ondo State. Nigeria. This was done through methodology multicriteria evaluation (MCE) using Saaty's analytical hierarchy process (AHP)...
July 12, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28700058/spatial-analysis-of-viral-hepatitis-and-schistosomiasis-coinfection-in-an-endemic-area-in-northeastern-brazil
#12
Márcio Bezerra Santos, Allan Dantas Dos Santos, Patrícia Pereira da Silva, Aline Silva Barreto, Erlon Oliveira Dos Santos, Alex Vianey Callado França, Constança Simões Barbosa, Karina Conceição Gomes Machado de Araújo
INTRODUCTION: This cross-sectional study analyzed the spatial distribution of hepatitis B or C virus (HBV/HBC) and schistosomiasis coinfection. METHODS: Serum samples were collected from patients with Schistosoma mansoni infection. These were tested for serological markers of HBV/HCV infection. The spatial distribution of coinfection was analyzed using intensity kernel estimation. RESULTS: Overall, 9.4% of individuals had contact with HBV and 1...
May 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28700054/sensitivity-and-specificity-of-the-circulating-cathodic-antigen-rapid-urine-test-in-the-diagnosis-of-schistosomiasis-mansoni-infection-and-evaluation-of-morbidity-in-a-low-endemic-area-in-brazil
#13
Fernanda Teixeira Ferreira, Thiago André Fidelis, Thiago Almeida Pereira, Alba Otoni, Leonardo Campos Queiroz, Frederico Figueiredo Amâncio, Carlos Maurício Antunes, José Roberto Lambertucci
INTRODUCTION: The Kato-Katz technique is the standard diagnostic test for Schistosoma mansoni infection in rural areas. However, the utility of this method is severely limited by the day-to-day variability in host egg excretion in the stool. In high-transmission areas, the point-of-care circulating cathodic antigen (POC-CCA) urine assay has proven to be a reliable test. However, investigations of the reliability of the POC-CCA assay in low-transmission regions are under way. This study aimed to evaluate the sensitivity and specificity of the POC-CCA assay and the morbidity of schistosomiasis in a low-endemic area in Brazil...
May 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28693436/urinary-schistosomiasis-among-vulnerable-children-in-a-rehabilitation-home-in-ibadan-oyo-state-nigeria
#14
Obioma Uchendu, Victoria Oladoyin, Michael Idowu, Oluwapelumi Adeyera, Oluwatosin Olabisi, Oluwafisayomi Oluwatosin, Gbemisola Leigh
BACKGROUND: Schistosomiasis is a disease of public health importance with long term complications mostly common among children, rural dwellers, poor and migrant workers. Studies have not documented the burden among migrant workers and their families. The study aimed to describe the burden of schistosomiasis and demographic characteristics among children of migrant workers residing in a rehabilitation home in Ibadan, Nigeria. METHODS: A cross-sectional study using sixty six children, who were tested following complaints of haematuria by six of them...
July 11, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28692692/geographic-strain-differentiation-of-schistosoma-japonicum-in-the-philippines-using-microsatellite-markers
#15
Kharleezelle J Moendeg, Jose Ma M Angeles, Ryo Nakao, Lydia R Leonardo, Ian Kendrich C Fontanilla, Yasuyuki Goto, Masashi Kirinoki, Elena A Villacorte, Pilarita T Rivera, Noboru Inoue, Yuichi Chigusa, Shin-Ichiro Kawazu
BACKGROUND: Microsatellites have been found to be useful in determining genetic diversities of various medically-important parasites which can be used as basis for an effective disease management and control program. In Asia and Africa, the identification of different geographical strains of Schistosoma japonicum, S. haematobium and S. mansoni as determined through microsatellites could pave the way for a better understanding of the transmission epidemiology of the parasite. Thus, the present study aims to apply microsatellite markers in analyzing the populations of S...
July 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28687411/systematic-review-of-bladder-cancer-outcomes-in-patients-with-spina-bifida
#16
K O Rove, D A Husmann, D T Wilcox, G J Vricella, T T Higuchi
BACKGROUND: In patients with congenital bladder anomalies, bladder augmentation is used as a last resort to reduce intravesical pressure, but concerns about malignant transformation in augmented patients were first raised in the 1980s. The best evidence to date indicates that augmentation does not appear to increase the risk of bladder cancer in spina bifida patients. To date, oncologic outcomes from patients with spina bifida with and without augmentation have only been available in small case reports...
June 1, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28686009/ferrocenyl-ruthenocenyl-and-benzyl-oxamniquine-derivatives-with-cross-species-activity-against-schistosoma-mansoni-and-schistosoma-haematobium
#17
Jeannine Hess, Gordana Panic, Malay Patra, Luciano Mastrobuoni, Bernhard Spingler, Saonli Roy, Jennifer Keiser, Gilles Gasser
Schistosomiasis is a parasitic disease that affects more than 250 million people annually, mostly children in poor, tropical, rural areas. Only one treatment (praziquantel) is available, putting control efforts at risk should resistance occur. In pursuit of treatment alternatives, we derivatized an old antischistosomal agent, oxamniquine (OXA). Four organometallic derivatives of OXA were synthesized and tested against Schistosoma mansoni in vitro and in vivo. Of these, a ferrocenyl derivative, 1, killed larval and adult worms 24 h postexposure in vitro, in contrast to OXA, which lacks in vitro activity against adult worms...
July 18, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/28685186/the-protein-pheromone-temptin-is-an-attractant-of-the-gastropod-biomphalaria-glabrata
#18
Emmanuel A Pila, Shauna J Peck, Patrick C Hanington
The freshwater snail Biomphalaria glabrata has drawn much research interest by virtue of it being one of the intermediate hosts of the parasitic flatworm Schistosoma mansoni, a causative agent of human schistosomiasis. Schistosomiasis is a chronic disease that affects over 260 million people globally, particularly in tropical and sub-tropical regions. One strategy that has been proposed as a way to prevent human infection by the parasite, involves the use of pheromone traps to lure the snail host away from areas of human activity...
July 6, 2017: Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology
https://www.readbyqxmd.com/read/28683113/impact-of-the-three-gorges-project-on-ecological-environment-changes-and-snail-distribution-in-dongting-lake-area
#19
Feiyue Li, Shujuan Ma, Yiyi Li, Hongzhuan Tan, Xunya Hou, Guanghui Ren, Kaiping Cai
BACKGROUND: The Three Gorges Dam (TGD) is a remarkable, far-reaching project in China. This study was conducted to assess the impact of TGD on changes in the ecological environment, snail distribution and schistosomiasis transmission in Dongting Lake area. METHODS: Hydrological data were collected from 12 monitoring sites in Hunan section of Yangtze River before and after TGD was established. Data on snail distribution and human schistosomiasis infection were also collected...
July 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28680583/enhanced-inflammatory-cell-profiles-in-schistosomiasis-induced-pulmonary-vascular-remodeling
#20
Zahara Ali, Djuro Kosanovic, Ewa Kolosionek, Ralph T Schermuly, Brian B Graham, Alistair Mathie, Ghazwan Butrous
Schistosomiasis (bilharzia) is a neglected parasitic disease caused by trematode flatworms of the genus Schistosoma which affects over 240 million people worldwide. It is characterized by the formation of inflammatory granulomas around deposited parasite eggs. Recent studies have revealed that immune and inflammatory responses play a crucial role in pathogenesis of schistosomiasis. The aim of this paper is to systematically evaluate the number and distribution of inflammatory cells in S. mansoni-infected mice at different doses and time points...
March 2017: Pulmonary Circulation
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