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Killer immunoglobulin like receptors

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https://www.readbyqxmd.com/read/29224003/human-leukocyte-antigen-g-inhibits-the-anti-tumor-effect-of-natural-killer-cells-via-immunoglobulin-like-transcript-2-in-gastric-cancer
#1
Rui Wan, Zi-Wei Wang, Hui Li, Xu-Dong Peng, Guang-Yi Liu, Jun-Ming Ou, An-Qi Cheng
BACKGROUND/AIMS: Human leukocyte antigen-G (HLA-G) plays an important role in inhibiting natural killer (NK) cell function and promoting immune escape. However, the specific mechanism of HLA-G on NK in gastric cancer (GC) remains not well understood. This study investigated the expression of HLA-G in GC and the role of HLA-G-effected NK cells in GC progression. METHODS: HLA-G expression in GC tissues obtained from 49 patients with GC was analyzed by immunohistochemistry and western blot...
December 7, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29222435/long-term-maintenance-of-peripheral-blood-derived-human-nk-cells-in-a-novel-human-il-15-transgenic-nog-mouse
#2
Ikumi Katano, Chiyoko Nishime, Ryoji Ito, Tsutomu Kamisako, Takuma Mizusawa, Yuyo Ka, Tomoyuki Ogura, Hiroshi Suemizu, Yutaka Kawakami, Mamoru Ito, Takeshi Takahashi
We generated a novel mouse strain expressing transgenic human interleukin-15 (IL-15) using the severe immunodeficient NOD/Shi-scid-IL-2Rγ null (NOG) mouse genetic background (NOG-IL-15 Tg). Human natural killer (NK) cells, purified from the peripheral blood (hu-PB-NK) of normal healthy donors, proliferated when transferred into NOG-IL-15 Tg mice. In addition, the cell number increased, and the hu-PB-NK cells persisted for 3 months without signs of xenogeneic graft versus host diseases (xGVHD). These in vivo-expanded hu-PB-NK cells maintained the original expression patterns of various surface antigens, including NK receptors and killer cell immunoglobulin-like receptor (KIR) molecules...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29197675/japanese-recipients-who-receive-hla-matched-hematopoietic-cell-transplantation-for-their-myeloid-leukemia-have-an-advantage-to-prevent-recurrence-if-they-have-homozygous-hla-c1
#3
Nobuyoshi Arima, Junya Kanda, Junji Tanaka, Toshio Yabe, Yasuo Morishima, Sung-Won Kim, Yuho Najima, Yukiyasu Ozawa, Tetsuya Eto, Heiwa Kanamori, Takehiko Mori, Naoki Kobayashi, Tadakazu Kondo, Hirohisa Nakamae, Naoyuki Uchida, Masami Inoue, Takahiro Fukuda, Tatsuo Ichinohe, Yoshiko Atsuta, Yoshinobu Kanda
Natural killer (NK) cells assume graft-versus-leukemia alloreactivity after hematopoietic stem-cell transplantation (HSCT) through their inhibitory killer cell immunoglobulin-like receptors (KIRs). KIR2D family members recognize human leukocyte antigen (HLA)-C alleles with Asn80 (HLA-C1) or Lys80 (HLA-C2). The predominance of HLA-C1 over HLA-C2 and a frequent KIR2DL1 possession are characteristic of Japanese people. We compared clinical outcomes among homozygous HLA-C1 (HLA-C1/C1) patients and heterozygous HLA-C1/C2 patients who underwent HLA-matched HSCT for hematological malignancies by assessing the data of 10,638 patients from the Japanese national registry...
November 29, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29191786/kir-hla-distribution-in-a-vietnamese-population-from-hanoi
#4
Leonardo Maldaner Amorim, Hoang van Tong, Nghiem Xuan Hoan, Luciana de Brito Vargas, Enilze Maria de Souza Fonseca Ribeiro, Maria Luiza Petzl-Erler, Angelica B W Boldt, Nguyen Linh Toan, Le Huu Song, Thirumalaisamy P Velavan, Danillo G Augusto
The KIR (killer cell immunoglobulin-like receptors) gene family codifies a group of receptors that recognize human leukocyte antigen (HLA) molecules and modulate natural killer (NK) cells response. Genetic diversity of KIR genes and HLA ligands has not yet been deeply investigated in South East Asia. Here, we characterized KIR gene presence/absence polymorphism of 14 KIR genes and two pseudogenes, as well as the frequencies of the ligands HLA-Bw4, HLA-C1 and HLA-C2 in a Vietnamese population from Hanoi (n=140)...
November 27, 2017: Human Immunology
https://www.readbyqxmd.com/read/29186116/immune-evasion-of-plasmodium-falciparum-by-rifin-via-inhibitory-receptors
#5
Fumiji Saito, Kouyuki Hirayasu, Takeshi Satoh, Christian W Wang, John Lusingu, Takao Arimori, Kyoko Shida, Nirianne Marie Q Palacpac, Sawako Itagaki, Shiroh Iwanaga, Eizo Takashima, Takafumi Tsuboi, Masako Kohyama, Tadahiro Suenaga, Marco Colonna, Junichi Takagi, Thomas Lavstsen, Toshihiro Horii, Hisashi Arase
Malaria is among the most serious infectious diseases affecting humans, accounting for approximately half a million deaths each year. Plasmodium falciparum causes most life-threatening cases of malaria. Acquired immunity to malaria is inefficient, even after repeated exposure to P. falciparum, but the immune regulatory mechanisms used by P. falciparum remain largely unknown. Here we show that P. falciparum uses immune inhibitory receptors to achieve immune evasion. RIFIN proteins are products of a polymorphic multigene family comprising approximately 150-200 genes per parasite genome that are expressed on the surface of infected erythrocytes...
November 29, 2017: Nature
https://www.readbyqxmd.com/read/29173894/generation-of-off-the-shelf-natural-killer-cells-from-peripheral-blood-cell-derived-induced-pluripotent-stem-cells
#6
Jieming Zeng, Shin Yi Tang, Lai Ling Toh, Shu Wang
Current donor cell-dependent strategies can only produce limited "made-to-order" therapeutic natural killer (NK) cells for limited patients. To provide unlimited "off-the-shelf" NK cells that serve many recipients, we designed and demonstrated a holistic manufacturing scheme to mass-produce NK cells from induced pluripotent stem cells (iPSCs). Starting with a highly accessible human cell source, peripheral blood cells (PBCs), we derived a good manufacturing practice-compatible iPSC source, PBC-derived iPSCs (PBC-iPSCs) for this purpose...
November 17, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/29159928/the-immunogenetics-of-neurological-disease
#7
REVIEW
Maneesh K Misra, Vincent Damotte, Jill A Hollenbach
Genes encoding antigen-presenting molecules within the human major histocompatibility complex (MHC) account for the highest component of genetic risk for many neurological diseases, such as multiple sclerosis, neuromyelitis optica, Parkinson's disease, Alzheimer's disease, schizophrenia, myasthenia gravis and amyotrophic lateral sclerosis. Myriad genetic, immunological and environmental factors may contribute to an individual's susceptibility to neurological disease. Here, we review and discuss the decades long research on the influence of genetic variation at the MHC locus and the role of immunogenetic killer cell immunoglobulin-like receptor (KIR) loci in neurological diseases, including multiple sclerosis, neuromyelitis optica, Parkinson's disease, Alzheimer's disease, schizophrenia, myasthenia gravis and amyotrophic lateral sclerosis...
November 21, 2017: Immunology
https://www.readbyqxmd.com/read/29149205/kir-content-genotypes-associate-with-carriage-of-hepatitis-b-surface-antigen-e-antigen-and-hbv-viral-load-in-gambians
#8
Louis-Marie Yindom, Maimuna Mendy, Christopher Bodimeade, Caroline Chambion, Peter Aka, Hilton C Whittle, Sarah L Rowland-Jones, Robert Walton
BACKGROUND: Hepatocellular carcinoma (HCC) causes over 800,000 deaths worldwide annually, mainly in low income countries, and incidence is rising rapidly in the developed world with the spread of hepatitis B (HBV) and C (HCV) viruses. Natural Killer (NK) cells protect against viral infections and tumours by killing abnormal cells recognised by Killer-cell Immunoglobulin-like Receptors (KIR). Thus genes and haplotypes encoding these receptors may be important in determining both outcome of initial hepatitis infection and subsequent chronic liver disease and tumour formation...
2017: PloS One
https://www.readbyqxmd.com/read/29122934/genotyping-natural-killer-immune-checkpoints%C3%A2-to-discover-biomarkers-of-response
#9
Nai-Kong V Cheung, Katharine C Hsu
Immune checkpoints have been a focus of immunotherapy in the recent decade. Killer-cell immunoglobulin-like receptors (KIR) and their cognate human leukocyte antigen (HLA) class I ligands have evolved as checkpoints to ensure self-tolerance of natural iiller (NK) cells. Both KIR and HLA genetic profiles are potential biomarkers of immunotherapy outcome.
November 9, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29111138/kir-like-activating-natural-killer-cell-receptors-and-their-association-with-complicated-malaria-in-north-india
#10
Swayam Prakash, Prabhat Ranjan, Ujjala Ghoshal, Suraksha Agrawal
Killer immunoglobulin-like receptors (KIRs) genomic regions have been suggested to influence malaria pathogenesis and infection susceptibility. KIRs are known as activating natural killer (NK) cell receptors, which upon binding to their corresponding human leukocyte antigen (HLA) ligands cause lysis of any infected cell. We have examined the potential association of KIR genes with complicated malaria (CM) among north Indians in this study and further evaluated the KIR receptor-HLA ligand association on the severity of the disease considering the uncomplicated malaria (UCM) subjects as control...
October 27, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29105756/kir-downregulation-by-il-12-15-18-unleashes-human-nk-cells-from-kir-hla-i-inhibition-and-enhances-killing-of-tumor-cells
#11
Eva-Maria Ewen, Jens H W Pahl, Matthias Miller, Carsten Watzl, Adelheid Cerwenka
To exploit autologous NK cells for cancer immunotherapy, it is highly relevant to circumvent killer cell immunoglobulin-like receptor (KIR)-mediated self-inhibition of human NK cells by HLA-I-expressing tumor cells. Here, we show that stimulation of NK cells with IL-12/15/18 for two days leads to downregulation of surface expression of the inhibitory KIR2DL2/L3, KIR2DL1 and KIR3DL1 receptors on peripheral blood NK cells. Downregulation of KIR expression was attributed to decreased KIR mRNA levels which could be re-induced already 3 days after re-culture in IL-2...
November 6, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/29105364/association-between-killer-cell-immunoglobulin-like-receptor-2ds5-gene-with-essential-hypertension-in-the-chinese-han-patients
#12
A L Wang, B Jiang, X Y Qian, Q Zhang, H Peng, Y H Zhang
Hypertension has been suggested to be mediated by immunity and inflammation. As immune system genes, killer cell immunoglobulin-like receptors (KIRs) genes play an important role in the pathogenesis of autoimmune diseases. We conducted a community population-based case-control study to analyse associations between KIR genes and hypertension. KIR genes were genotyped using sequence-specific primer polymerase chain reaction in 380 unrelated essential hypertensives and 527 normotensives. The frequencies of KIR2DS5 gene were significantly decreased in participants with high high-sensitivity C-reactive protein (hsCRP) compared with participants with low hsCRP (17...
November 3, 2017: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/29101448/discovery-of-gorilla-mhc-c-expressing-c1-ligand-for-kir
#13
Jörg B Hans, Linda Vigilant
In comparison to humans and chimpanzees, gorillas show low diversity at MHC class I genes (Gogo), as reflected by an overall reduced level of allelic variation as well as the absence of a functionally important sequence motif that interacts with killer cell immunoglobulin-like receptors (KIR). Here, we use recently generated large-scale genomic sequence data for a reassessment of allelic diversity at Gogo-C, the gorilla orthologue of HLA-C. Through the combination of long-range amplifications and long-read sequencing technology, we obtained, among the 35 gorillas reanalyzed, three novel full-length genomic sequences including a coding region sequence that has not been previously described...
November 3, 2017: Immunogenetics
https://www.readbyqxmd.com/read/29100942/association-between-kir-genes-and-dust-mite-sensitization-in-a-brazilian-population
#14
Marcela Caleffi da Costa Lima Caniatti, Sueli Donizete Borelli, Ana Lúcia Falavigna Guilherme, Soraya Barrionuevo Franzener, Luiza Tamie Tsuneto
BACKGROUND: Killer cell immunoglobulin-like receptors (KIRs), found on the surface of natural killer (NK) cells, play a key role in controlling the innate response. Such response depends on a series of cellular interactions between these receptors and HLA activating/inhibiting ligands. Atopic diseases have been associated with genes that regulate cytokine production and HLA genes, which may either protect or predispose to hypersensitivity. OBJECTIVE: To verify an association study of KIR genes with sensitization to the following mites: Dermatophagoides farinae, Dermatophagoides pteronyssinus, and Blomia tropicalis...
October 31, 2017: Human Immunology
https://www.readbyqxmd.com/read/29099970/expression-of-kir2ds1-does-not-significantly-contribute-to-nk-cell-cytotoxicity-in-hla-c1-c2-heterozygous-haplotype-b-donors
#15
Karla Baltner, Ayline Kübler, Marina Pal, Monika Balvociute, Markus Mezger, Rupert Handgretinger, Maya C André
NK cells are functionally controlled by the killer immunoglobulin-like receptor (KIR) family that comprises inhibitory (iKIR) and activating (aKIR) members. Genetic association studies suggest that donors expressing aKIRs next to iKIRs will be superior donors in the setting of hematopoietic stem cell transplantation of patients with leukemia. However, contrary evidence states that aKIR expression may be irrelevant or even detrimental. Using a complex methodology incorporating KIR-Q-PCR, double fluorescence and viSNE analysis, we characterized subset distribution patterns and functionality in haplotype A donors which lack aKIRs and haplotype B donors that express a variety of B-specific genes...
November 1, 2017: International Immunology
https://www.readbyqxmd.com/read/29097997/the-more-the-better-do-the-right-thing-for-natural-killer-immunotherapy-in-acute-myeloid-leukemia
#16
REVIEW
Sarah Parisi, Mariangela Lecciso, Darina Ocadlikova, Valentina Salvestrini, Marilena Ciciarello, Dorian Forte, Giulia Corradi, Michele Cavo, Antonio Curti
Natural killer (NK) cells are circulating CD3(-) lymphocytes, which express CD56 or CD16 and an array of inhibitory receptors, called killer-immunoglobulin-like receptors (KIRs). Alloreactive KIR-ligand mismatched NK cells crucially mediate the innate immune response and have a well-recognized antitumor activity. Adoptive immunotherapy with alloreactive NK cells determined promising clinical results in terms of response in acute myeloid leukemia (AML) patients and several data demonstrated that response can be influenced by the composition of NK graft...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29078989/an-historical-approach-to-the-genetic-distribution-of-kir-and-hla-ligands-in-eastern-sicilians-compared-to-modern-descendants-of-their-invaders
#17
Cristina Capittini, Francesco Messina, Fabrizio Puglisi, Maria Azzaro, Sebastiana Toscano, Annalisa De Silvestri, Carmine Tinelli, Grazia Sortino
A geographical stratification of Killer Immunoglobulin-like Receptors (KIR) has been reported worldwide. We first analyzed the distribution of 15 KIR genes in a sample of 50 East-Sicilians (ES). We used a Principal Component Analysis (PCA) to compare the KIR genetic content among ES and 10 modern populations who are descendants of the ancient invaders of Sicily: Spanish, French, Norwegians, Swedes, Finns, Tunisians, Moroccans, Arabs, Greeks, Turks. We also included a sample of Sardinians, and Senegalese (as outliner group)...
October 24, 2017: Human Immunology
https://www.readbyqxmd.com/read/29075265/kir3ds1-hla-b-bw4-80ile-genotype-is-correlated-with-the-ifn-%C3%AE-therapy-response-in-hepatitis-b-e-antigen-positive-chronic-hepatitis-b
#18
Wenting Li, Xiaokun Shen, Binqing Fu, Chuang Guo, Yanyan Liu, Ying Ye, Rui Sun, Jiabin Li, Zhigang Tian, Haiming Wei
To date, several on-treatment-level virological and serological indices that may predict the response to interferon alpha (IFN-α) have been reported. However, no effective predictors, such as drug-response genes, that can be detected before administration of anti-hepatitis B virus (HBV) therapy with IFN-α, have been found. In the diverse range of chronic viral infection, genes that affect human immunity play important roles in understanding host and viral co-evolution. Killer-cell immunoglobulin-like receptors (KIRs), which are highly polymorphic at the allele and haplotype levels, participate in the antiviral function of natural killer (NK) cells via fine-tuning inhibition and activation of NK-cell responses that occur when the NK cells interact with human leukocyte antigen (HLA) class I molecules on target cells...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29072292/il-1r8-is-a-checkpoint-in-nk-cells-regulating-anti-tumour-and-anti-viral-activity
#19
Martina Molgora, Eduardo Bonavita, Andrea Ponzetta, Federica Riva, Marialuisa Barbagallo, Sébastien Jaillon, Branka Popović, Giovanni Bernardini, Elena Magrini, Francesca Gianni, Santiago Zelenay, Stipan Jonjić, Angela Santoni, Cecilia Garlanda, Alberto Mantovani
Interleukin-1 receptor 8 (IL-1R8, also known as single immunoglobulin IL-1R-related receptor, SIGIRR, or TIR8) is a member of the IL-1 receptor (ILR) family with distinct structural and functional characteristics, acting as a negative regulator of ILR and Toll-like receptor (TLR) downstream signalling pathways and inflammation. Natural killer (NK) cells are innate lymphoid cells which mediate resistance against pathogens and contribute to the activation and orientation of adaptive immune responses. NK cells mediate resistance against haematopoietic neoplasms but are generally considered to play a minor role in solid tumour carcinogenesis...
November 2, 2017: Nature
https://www.readbyqxmd.com/read/29070683/stability-and-expression-levels-of-hla-c-on-the-cell-membrane-modulate-hiv-1-infectivity
#20
Francesca Parolini, Priscilla Biswas, Michela Serena, Francesca Sironi, Valentina Muraro, Elisabetta Guizzardi, Lucia Cazzoletti, Maria Teresa Scupoli, Davide Gibellini, Elisabetta Ugolotti, Roberto Biassoni, Alberto Beretta, Mauro Malnati, Maria Grazia Romanelli, Donato Zipeto
HLA-C expression is associated with a differential ability to control HIV-1 infection. Higher HLA-C levels may lead to a better control of HIV-1 infection through both a higher efficiency of antigen presentation to cytotoxic T lymphocytes (CTLs), as well as the triggering of activating Killer Immunoglobulin like receptors (KIR) on NK-cells, whereas lower levels may provide a poor HIV-1 control and a rapid progression toward AIDS.We characterized the relative amount of HLA-C heterotrimers (heavy chain/β2m/peptide) and HLA-C free heavy chains on PBMC from healthy blood donors harboring both alleles with stable or unstable binding to β2m/peptide...
October 25, 2017: Journal of Virology
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