keyword
MENU ▼
Read by QxMD icon Read
search

Killer immunoglobulin like receptors

keyword
https://www.readbyqxmd.com/read/29666399/genotype-b-of-killer-cell-immunoglobulin-like-receptor-is-related-with-gastric-cancer-lesions
#1
Eric G Hernandez, Oswaldo Partida-Rodriguez, Margarita Camorlinga-Ponce, Miriam Nieves-Ramirez, Irma Ramos-Vega, Javier Torres, Martha Perez-Rodriguez
NK cells are important in innate immunity for their capacity to kill infected or cancer cells. The killer cell immunoglobulin-like receptors (KIR) are a family of polymorphic genes with inhibitory and activating functions. The main driving force for gastric cancer (GC) development is a chronic response, which causes an increase of NK cells in the gastric mucosa. The aim of this work was to study polymorphisms in KIR genes in patients with either GC or non-atrophic gastritis (NAG). We studied 242 patients (130 with NAG and 112 with GC) and contrasted with 146 asymptomatic individuals...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29664957/killer-cell-immunoglobulin-like-receptors-associate-with-hiv-1-infection-in-a-narrow-source-han-chinese-cohort
#2
Linghang Wang, Yonghong Zhang, Keyi Xu, Tao Dong, Sarah Rowland-Jones, Louis-Marie Yindom
BACKGROUND: The HIV pandemic remains the most serious challenge to public health worldwide. The hallmark characteristics of the disease is the eventual failure of the immune system to control opportunistic infections and death. However not everyone who has HIV develops the disease at the same rate and so we are studying how the immune system works to control the virus in those who have been infected for decades and remain relatively healthy without the need of anti-retroviral therapy (ART)...
2018: PloS One
https://www.readbyqxmd.com/read/29649328/association-between-kir-hla-combination-and-ulcerative-colitis-and-crohn-s-disease-in-a-japanese-population
#3
Hiromi Saito, Atsuhiro Hirayama, Takeji Umemura, Satoru Joshita, Kenji Mukawa, Tomoaki Suga, Eiji Tanaka, Masao Ota
Inflammatory bowel disease (IBD) consists of ulcerative colitis (UC) and Crohn's disease (CD). Natural killer cell responses play a crucial role in autoimmune disease through innate immunity, in which killer cell immunoglobulin-like receptors (KIRs) are closely involved. Although the genetic combination of KIRs with their specific HLA class I ligands has been associated with IBD in Caucasians, such KIR-HLA receptor-ligand combinations are not fully understood in the Japanese. We investigated 14 KIR genes along with HLA-Bw and -C ligands in 90 patients with UC and 50 patients with CD and compared them with the characteristics of 325 healthy control subjects...
2018: PloS One
https://www.readbyqxmd.com/read/29579887/donor-selection-based-on-killer-cell-immunoglobulin-like-receptor-kir-genotype-may-improve-outcome-after-t-cell-replete-haploidentical-transplantation
#4
A Torío, M J Pascual, I Vidales, M Ortiz, A Caballero, A I Heiniger
BACKGROUND: In haploidentical stem cell transplantation (SCT), the "ideal donor" selection is not performed in a standardized way according to killer cell immunoglobulin-like receptor (KIR) genotype expressed by potential donors. The aim of this study was to evaluate the relevance of KIR genotype in a series of patients submitted to haploidentical SCT in our center. METHODS: We retrospectively analyzed 30 patients that were prepared with the use of a conditioning regimen including thiotepa-busulfan-fludarabine with high doses of post-transplantation cyclophosphamide (CyPT) and tacrolimus as graft-versus-host disease (GVHD) prophylaxis...
March 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29577936/possible-involvement-of-human-mast-cells-in-the-establishment-of-pregnancy-via-killer-cell-ig-like-receptor-2dl4
#5
Chiyuki Ueshima, Tatsuki R Kataoka, Masahiro Hirata, Akihiko Sugimoto, Yoshiki Iemura, Sachiko Minamiguchi, Takashi Nomura, Hironori Haga
The involvement of mast cells in the establishment of pregnancy is unclear. Herein, we found that human mast cells are present in the decidual tissues of parous women and expressed a human-specific protein killer cell Ig-like receptor (KIR) 2DL4, a receptor for human leukocyte antigen G expressed on human trophoblasts. In contrast, decreased numbers of decidual mast cells and reduced KIR2DL4 expression were observed in these cells of infertile women who had undergone long-term corticosteroid treatment. Co-culture of the human mast cell line, LAD2, and human trophoblast cell line, HTR-8/SVneo, accelerated the migration and tube formation of HTR-8/SVneo cells in a KIR2DL4-dependent manner...
March 22, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29570783/defining-the-role-of-nk-cells-during-dengue-virus-infection
#6
REVIEW
Anuja Mathew
In recent years, our understanding of the complex number of signals that need to be integrated between a diverse number of receptors present on NK cells and ligands present on target cells has improved. Here, we review the progress made in identifying interactions between dengue viral peptides presented on HLA Class 1 molecules with inhibitory and activating killer-like immunoglobulin receptors on NK cells, direct interactions of viral proteins with NK cell receptors, the involvement of dengue virus-specific antibodies in mediating antibody dependent cell mediated cytotoxicity and the role of soluble factors in modulating NK cell responses...
March 23, 2018: Immunology
https://www.readbyqxmd.com/read/29556297/abnormal-populations-and-functions-of-natural-killer-cells-in-patients-with-myelodysplastic-syndromes
#7
Wei Zhang, Xinyan Xie, Huijing Mi, Jinwan Sun, Shaoxue Ding, Lijuan Li, Hui Liu, Huaquan Wang, Rong Fu, Zonghong Shao
Myelodysplastic syndromes (MDS) are clonal stem cell disorders characterized by ineffective hematopoiesis that lead to leukemia. Disorders of the immune system serve important functions in the pathophysiology and progression of this disease. Different levels or mechanisms of natural killer (NK) cells in patients with MDS have been measured in previous studies, making it challenging to understand the pathogenesis of NK cytotoxicity. The present study investigated the frequency of NK cell-mediated antibody-dependent cellular cytotoxicity and explored the function of NK cells by their activating receptors, inhibition signals, degranulation and cytotoxicity factors...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29549412/donor-recipient-killer-immunoglobulin-like-receptor-kir-genotype-matching-has-a-protective-effect-on-chronic-graft-versus-host-disease-and-relapse-incidence-following-hla-identical-sibling-hematopoietic-stem-cell-transplantation
#8
Ugur Sahin, Klara Dalva, Funda Gungor, Celalettin Ustun, Meral Beksac
Impact of donor-recipient killer immunoglobulin-like receptor (KIR) gene-gene matching on transplant outcomes is still inconclusive. Recent data suggest that killer cell immunoglobulin-like receptor (KIR) regulated natural killer cell (NK cell) activity may contribute to graft versus leukemia (GvL) effects and graft versus host disease (GvHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). This case-control study aims to evaluate the effects of both aKIR and iKIR donor-recipient genotype matching on the outcomes of T cell replete HLA-identical sibling allo-HSCTs in a homogenous young patient population with myeloid leukemias...
March 16, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29549293/prognostic-role-of-kir-genes-and-hla-c-after-hematopoietic-stem-cell-transplantation-in-a-patient-cohort-with-acute-myeloid-leukemia-from-a-consanguineous-community
#9
Ameera Gaafar, Atia Sheereen, Fahad Almohareb, Abdelmoneim Eldali, Naeem Chaudhri, Said Y Mohamed, Amr Hanbali, Marwan Shaheen, Feras Alfraih, Riad El Fakih, Alia Iqneibi, Riad Youniss, Tusneem Elhassan, Shahrukh Hashmi, Mahmud Aljurf, Khalid Alhussein
NK cell activity is tuned by a balance of activating and inhibitory signals transmitted via their respective receptors, including killer immunoglobulin-like receptors (KIRs). The impact of NK cells on graft-versus-leukemia following hematopoietic stem cell transplantation (HSCT) is well established. These effects sometimes lead to GvHD. The link between KIR/HLA interaction and GvHD remains unclear. Herein, we studied the impact of the KIR/HLA interaction on HSCT outcomes in a longitudinal follow-up study of a highly consanguineous HLA-matched related cohort...
March 16, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29541873/immune-modulation-in-heart-failure-the-promise-of-novel-biologics
#10
REVIEW
Paulino Alvarez, Alexandros Briasoulis
PURPOSE OF REVIEW: Immune system activation plays a central role in heart failure progression. Large-scale immune modulatory clinical trials targeting tumor necrosis factor-α and broad spectrum immune modulation have been negative. The objective of this review is to highlight past, present, and what is in the horizon for the immunomodulation in heart failure with a focus of biologics. RECENT FINDINGS: Strategies targeting interleukin-1 pathway are currently undergoing clinical evaluation and data from pilot studies are promising...
March 15, 2018: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29514913/contribution-of-nk-cell-education-to-both-direct-and-anti-hiv-1-antibody-dependent-nk-cell-functions
#11
Anne B Kristensen, Stephen J Kent, Matthew S Parsons
Antibody Fc-dependent functions are linked to prevention and control of HIV-1 infection. Basic NK cell biology is likely key to understanding the contributions anti-HIV-1 antibody-dependent NK cell activation and cytolysis make to HIV-1 susceptibility and disease progression. The importance of NK cell education through inhibitory receptors specific for self-HLA-I in determining the potency of anti-HIV-1 antibody mediated NK cell activation and cytolysis is controversial. To address this issue more definitively we utilized HLA-I genotyping, flow cytometry staining panels and cytolysis assays to assess the functionality of educated and non-educated peripheral blood NK cells...
March 7, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29470425/major-histocompatibility-complex-and-hematopoietic-stem-cell-transplantation-beyond-the-classical-hla-polymorphism
#12
REVIEW
Alice Bertaina, Marco Andreani
Allogeneic hematopoietic stem cell transplantation (HSCT) represents a curative treatment for many patients with hematological malignant or non-malignant disorders. Evaluation of potential donors for HSCT includes a rigorous assessment of the human leukocyte antigens (HLA) match status of family members, and the identification of suitable unrelated donors. Genes encoding transplantation antigens are placed both within and outside the major histocompatibility complex (MHC). The human MHC is located on the short arm of chromosome 6 and contains a series of genes encoding two distinct types of highly polymorphic cell surface glycoproteins...
February 22, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29461980/killer-cell-immunoglobulin-like-receptor-3dl1-variation-modifies-hla-b-57-protection-against-hiv-1
#13
Maureen P Martin, Vivek Naranbhai, Patrick R Shea, Ying Qi, Veron Ramsuran, Nicolas Vince, Xiaojiang Gao, Rasmi Thomas, Zabrina L Brumme, Jonathan M Carlson, Steven M Wolinsky, James J Goedert, Bruce D Walker, Florencia P Segal, Steven G Deeks, David W Haas, Stephen A Migueles, Mark Connors, Nelson Michael, Jacques Fellay, Emma Gostick, Sian Llewellyn-Lacey, David A Price, Bernard A Lafont, Phillip Pymm, Philippa M Saunders, Jacqueline Widjaja, Shu Cheng Wong, Julian P Vivian, Jamie Rossjohn, Andrew G Brooks, Mary Carrington
HLA-B*57 control of HIV involves enhanced CD8+ T cell responses against infected cells, but extensive heterogeneity exists in level of HIV control among B*57+ individuals. Using whole genome sequencing of untreated B*57+ HIV-1 infected controllers and non-controllers, we identified a single variant (rs643347A/G) encoding an isoleucine to valine substitution at position 47 (I47V) of the inhibitory killer cell immunoglobulin-like receptor, KIR3DL1, as the only significant modifier of B*57 protection. The association replicated in an independent cohort and across multiple outcomes...
February 20, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29459477/intrinsic-functional-potential-of-nk-cell-subsets-constrains-retargeting-driven-by-chimeric-antigen-receptors
#14
Vincent Yi Sheng Oei, Marta Siernicka, Agnieszka Graczyk-Jarzynka, Hanna Julie Hoel, Weiwen Yang, Daniel Palacios, Hilde Almåsbak, Malgorzata Bajor, Dennis Clement, Ludwig Brandt, Björn Önfelt, Jodie Goodridge, Magdalena Winiarska, Radoslaw Zagozdzon, Johanna Olweus, Jon-Amund Kyte, Karl-Johan Malmberg
Natural killer (NK) cells hold potential as a source of allogeneic cytotoxic effector cells for chimeric antigen receptor (CAR)-mediated therapies. Here, we explored the feasibility of transfecting CAR-encoding mRNA into primary NK cells and investigated how the intrinsic potential of discrete NK-cell subsets affects retargeting efficiency. After screening five second- and third-generation anti-CD19 CAR constructs with different signaling domains and spacer regions, a third-generation CAR with the CH2-domain removed was selected based on its expression and functional profiles...
February 19, 2018: Cancer Immunology Research
https://www.readbyqxmd.com/read/29456538/an-uncoupling-of-canonical-phenotypic-markers-and-functional-potency-of-ex-vivo-expanded-natural-killer-cells
#15
Nicole A P Lieberman, Kole DeGolier, Kristen Haberthur, Harrison Chinn, Kara W Moyes, Myriam N Bouchlaka, Kirsti L Walker, Christian M Capitini, Courtney A Crane
Recent advances in cellular therapies for patients with cancer, including checkpoint blockade and ex vivo -expanded, tumor-specific T cells, have demonstrated that targeting the immune system is a powerful approach to the elimination of tumor cells. Clinical efforts have also demonstrated limitations, however, including the potential for tumor cell antigenic drift and neoantigen formation, which promote tumor escape and recurrence, as well as rapid onset of T cell exhaustion in vivo . These findings suggest that antigen unrestricted cells, such as natural killer (NK) cells, may be beneficial for use as an alternative to or in combination with T cell based approaches...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29454072/killer-cell-immunoglobulin-like-receptor-genotypes-in-the-turkish-population
#16
Mehmet Onur Elbaşi, Aysın Tulunay-Virlan, Emel Ekşioğlu-Demiralp
One hundred eighty-seven healthy and unrelated volunteers from various regions of Turkey were selected for the study. Killer-cell immunoglobulin-like receptors (KIR) genotyping was performed by polymerase chain reaction using commercial sequence-specific oligonucleotide probe (SSOP) kits. Gene frequencies of the Turkish population were determined by direct counting of the positive and negative loci. The genotype data is publicly available in the Allele Frequencies Net Database under the population name "Turkey KIR pop 3" number "3399"...
February 14, 2018: Human Immunology
https://www.readbyqxmd.com/read/29448052/kir-and-hla-ligands-demonstrate-genetic-inheritance-diversity-in-japanese-descendants-from-paran%C3%A3-brazil
#17
Josiane Bazzo de Alencar, Joana Maira Valentini Zacarias, Barbara Leticia da Silva Guedes de Moura, Marco Antônio Braga, Jeane Eliete Laguila Visentainer, Ana Maria Sell
In order to investigate killer immunoglobulin-like receptors (KIR) and their ligands, human leukocyte antigen (HLA), diversity in the Brazilian population influenced by migrations, unrelated Brazilian Japanese descendants were selected and genotyped for the KIR genes and HLA class I allele groups. Genetic heterogeneity in Brazil Paraná Japanese was observed for KIR genes, whose frequency distributions demonstrated similarity with mixed Brazilian populations and with the Japanese population, suggesting gene flow...
February 12, 2018: Human Immunology
https://www.readbyqxmd.com/read/29447367/endometrial-natural-killer-nk-cells-reveal-a-tissue-specific-receptor-repertoire
#18
D Feyaerts, T Kuret, B van Cranenbroek, S van der Zeeuw-Hingrez, O W H van der Heijden, A van der Meer, I Joosten, R G van der Molen
STUDY QUESTION: Is the natural killer (NK) cell receptor repertoire of endometrial NK (eNK) cells tissue-specific? SUMMARY ANSWER: The NK cell receptor (NKR) expression profile in pre-pregnancy endometrium appears to have a unique tissue-specific phenotype, different from that found in NK cells in peripheral blood, suggesting that these cells are finely tuned towards the reception of an allogeneic fetus. WHAT IS KNOWN ALREADY: NK cells are important for successful pregnancy...
February 13, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29446443/association-of-killer-cell-immunoglobulin-like-receptors-with-spontaneous-clearance-of-hepatitis-c-virus-in-the-chinese-population
#19
Zhengang Shan, Jieting Huang, Qiao Liao, Ke Huang, Min Wang, Ru Xu, Xi Tang, Weiyun Zhang, Kenrad Nelson, Yongshui Fu, Chengyao Li, Xia Rong
BACKGROUND: Natural killer (NK) cells are critical components in innate immune response to viral infection. Killer cell immunoglobulin-like receptors (KIRs) are involved in regulating the balance of activation or inhibitory function of NK cells. However, the association of KIRs with the spontaneous clearance of hepatitis C virus (HCV) remains unclear in the Chinese population. STUDY DESIGN AND METHODS: A total of 407 HCV-seropositive voluntary blood donors were recruited, including 203 with spontaneous viral clearance and 204 with chronic infection...
February 15, 2018: Transfusion
https://www.readbyqxmd.com/read/29413815/natural-killer-cell-education-in-human-health-and-disease
#20
REVIEW
Jeanette E Boudreau, Katharine C Hsu
Natural killer (NK) cells maintain immune homeostasis by detecting and eliminating damaged cells. Simultaneous activating and inhibitory input are integrated by NK cells, with the net signal prompting cytotoxicity and cytokine production, or inhibition. Chief among the inhibitory ligands for NK cells are 'self' human leukocyte antigen (HLA) molecules, which are sensed by killer immunoglobulin-like receptors (KIR). Through a process called 'education', the functional capabilities of each NK cell are counterbalanced by their sensitivity for inhibition by co-inherited 'self' HLA...
January 27, 2018: Current Opinion in Immunology
keyword
keyword
41013
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"