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https://www.readbyqxmd.com/read/28915239/structural-basis-for-the-high-specificity-of-a-trypanosoma-congolense-immunoassay-targeting-glycosomal-aldolase
#1
Joar Pinto, Steven Odongo, Felicity Lee, Vaiva Gaspariunaite, Serge Muyldermans, Stefan Magez, Yann G-J Sterckx
BACKGROUND: Animal African trypanosomosis (AAT) is a neglected tropical disease which imposes a heavy burden on the livestock industry in Sub-Saharan Africa. Its causative agents are Trypanosoma parasites, with T. congolense and T. vivax being responsible for the majority of the cases. Recently, we identified a Nanobody (Nb474) that was employed to develop a homologous sandwich ELISA targeting T. congolense fructose-1,6-bisphosphate aldolase (TcoALD). Despite the high sequence identity between trypanosomatid aldolases, the Nb474-based immunoassay is highly specific for T...
September 15, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28910299/access-to-benznidazole-for-chagas-disease-in-the-united-states-cautious-optimism
#2
Jonathan D Alpern, Rogelio Lopez-Velez, William M Stauffer
Drugs for neglected tropical diseases (NTD) are being excessively priced in the United States. Benznidazole, the first-line drug for Chagas disease, may become approved by the Food and Drug Administration (FDA) and manufactured by a private company in the US, thus placing it at risk of similar pricing. Chagas disease is an NTD caused by Trypanosoma cruzi; it is endemic to Latin America, infecting 8 million individuals. Human migration has changed the epidemiology causing nonendemic countries to face increased challenges in diagnosing and managing patients with Chagas disease...
September 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28910281/global-health-policy-and-neglected-tropical-diseases-then-now-and-in-the-years-to-come
#3
Thomas Fürst, Paola Salari, Laura Monzón Llamas, Peter Steinmann, Christopher Fitzpatrick, Fabrizio Tediosi
No abstract text is available yet for this article.
September 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28905944/snakebite-envenoming
#4
REVIEW
José María Gutiérrez, Juan J Calvete, Abdulrazaq G Habib, Robert A Harrison, David J Williams, David A Warrell
Snakebite envenoming is a neglected tropical disease that kills >100,000 people and maims >400,000 people every year. Impoverished populations living in the rural tropics are particularly vulnerable; snakebite envenoming perpetuates the cycle of poverty. Snake venoms are complex mixtures of proteins that exert a wide range of toxic actions. The high variability in snake venom composition is responsible for the various clinical manifestations in envenomings, ranging from local tissue damage to potentially life-threatening systemic effects...
September 14, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28902908/histological-assessment-of-granulomas-in-natural-and-experimental-schistosoma-mansoni-infections-using-whole-slide-imaging
#5
Kátia B Amaral, Thiago P Silva, Felipe F Dias, Kássia K Malta, Florence M Rosa, Sócrates F Costa-Neto, Rosana Gentile, Rossana C N Melo
The pathology of schistosomiasis mansoni, a neglected tropical disease of great clinical and socioeconomic importance, results from the parasite eggs that become trapped in host tissues, particularly in the liver and intestines. Continuous antigenic stimulation from these eggs leads to recruitment of inflammatory cells to the sites of infection with formation of periovular granulomas. These complex structures have variable size and composition and are the most striking histopathological feature of schistosomiasis mansoni...
2017: PloS One
https://www.readbyqxmd.com/read/28899362/nationwide-cross-sectional-survey-of-schistosomiasis-and-soil-transmitted-helminthiasis-in-sudan-study-protocol
#6
Seungman Cha, Sung-Tae Hong, Young-Ha Lee, Keon Hoon Lee, Dae Seong Cho, Jinmoo Lee, Jong-Yil Chai, Mousab Siddig Elhag, Soheir Gabralla Ahmad Khaled, Mustafa Khidir Mustafa Elnimeiri, Nahid Abdelgadeir Ali Siddig, Hana Abdelrazig, Sarah Awadelkareem, Azza Tag Eldin Elshafie, Hassan Ahmed Hassan Ahmed Ismail, Mutamad Amin
BACKGROUND: Schistosomiasis and soil-transmitted helminthiasis (STHs) are target neglected tropical diseases (NTDs) of preventive chemotherapy, but the control and elimination of these diseases have been impeded due to resource constraints. Few reports have described study protocol to draw on when conducting a nationwide survey. We present a detailed methodological description of the integrated mapping of schistosomiasis and STHs on the basis of our experiences, hoping that this protocol can be applied to future surveys in similar settings...
September 12, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28892479/towards-chagas-disease-elimination-neonatal-screening-for-congenital-transmission-in-rural-communities
#7
Pamela Marie Pennington, José Guillermo Juárez, Margarita Rivera Arrivillaga, Sandra María De Urioste-Stone, Katherine Doktor, Joe P Bryan, Clara Yaseli Escobar, Celia Cordón-Rosales
Chagas disease is a neglected tropical disease that continues to affect populations living in extreme poverty in Latin America. After successful vector control programs, congenital transmission remains as a challenge to disease elimination. We used the PRECEDE-PROCEED planning model to develop strategies for neonatal screening of congenital Chagas disease in rural communities of Guatemala. These communities have persistent high triatomine infestations and low access to healthcare. We used mixed methods with multiple stakeholders to identify and address maternal-infant health behaviors through semi-structured interviews, participatory group meetings, archival reviews and a cross-sectional survey in high risk communities...
September 11, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28883978/sanitation-for-all-the-global-opportunity-to-increase-transgenerational-health-gains-and-better-understand-the-link-between-ncds-and-ntds-a-scoping-review
#8
REVIEW
Shiva Raj Mishra, Meghnath Dhimal, Parash Mani Bhandari, Bipin Adhikari
The global sanitation divide is narrowing. However, in many countries in Asia and Africa, the gap between rural and urban sanitation coverage is rather widening. Moreover, there is an increase in the burden of non-communicable diseases (NCDs), notwithstanding to the already high burden of neglected tropical diseases (NTDs). A scientific query is building on how the global 'sanitation for all' goal will address the dual burden of NTDs and NCDs, and help further understand the link between the two. This paper aims to discuss the link between i) sanitation and NTDs, and ii) sanitation and NCDs through a scoping review of the literature...
2017: Tropical Diseases, Travel Medicine and Vaccines
https://www.readbyqxmd.com/read/28881447/combination-of-histopathology-and-ft-raman-spectroscopy-for-the-study-of-experimental-paracoccidiodomycosis-pcm-in-the-spleen
#9
Elaine Sciuniti Benites Mansano, Gutierrez Rodriguês de Morais, Edilaine Martins Moratto, Francielle Sato, Mauro Luciano Baesso, Antonio Neto Medina, Terezinha Inez Estivalet Svidzinski, Luzmarina Hernandes
Paracoccidioides brasiliensis (Pb) can disseminate through the lymphatic and hematogenic pathways. As a result the spleen and other lymphoid organs are targets of paracoccidioidomycosis. There are few studies describing this disease in the spleen and more detailed descriptions are required. The present study combines Histopathology and Fourier Transform Raman Spectroscopy (FT-Raman) methods to study spleen infected by Pb. The Swiss mice were euthanized after one, two, four and eight weeks of infection with Pb and their spleens were removed for ex vivo analyzes...
September 7, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/28881289/efficacy-of-a-series-of-alpha-pyrone-derivatives-against-leishmania-l-infantum-and-trypanosoma-cruzi
#10
Andre Gustavo Tempone, Daiane Dias Ferreira, Marta Lopes Lima, Thais Alves Costa Silva, Samanta E T Borborema, Juliana Quero Reimão, Mariana K Galuppo, Juliana Mariotti Guerra, Angelie J Russell, Graham M Wynne, Roy Y L Lai, Melissa M Cadelis, Brent R Copp
The neglected tropical diseases Chagas disease and leishmaniasis affect together more than 20 million people living mainly in developing countries. The mainstay of treatment is chemotherapy, however the drugs of choice, which include benznidazole and miltefosine, are toxic and have numerous side effects. Safe and effective therapies are urgently needed. Marine alpha-pyrones have been previously identified as scaffolds with potential antiprotozoan activities. In this work, using a phenotypic screen, twenty-seven examples of 3-substituted 4-hydroxy-6-methyl alpha-pyrones were synthesized and their antiparasitic efficacy evaluated against Leishmania (L...
September 1, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28878432/ethiopia-schistosomiasis-and-soil-transmitted-helminthes-control-programme-progress-and-prospects
#11
Nebiyu Negussu, Birhan Mengistu, Biruck Kebede, Kebede Deribe, Ephrem Ejigu, Gemechu Tadesse, Kalkidan Mekete, Mesfin Sileshi
Schistosomiasis and soil-transmitted helminthes are among seventeen WHO prioritized neglected tropical diseases that infect humans. These parasitic infections can be treated using single-dose and safe drugs. Ethiopia successfully mapped the distribution of these infections nationwide. According to the mapping there are an estimated 37.3 million people living in schistosomiasis endemic areas, and 79 million in schistosomiasis and soil-transmitted helminthes endemic areas. The Federal Ministry of Health successfully scaled up Schistosomiasis and schistosomiasis and soil-transmitted helminthes intervention in endemic areas and treated over 19 million individuals in 2015...
2017: Ethiopian Medical Journal
https://www.readbyqxmd.com/read/28878431/podoconiosis-in-ethiopia-from-neglect-to-priority-public-health-problem
#12
Kebede Deribe, Biruck Kebede, Belete Mengistu, Henok Negussie, Mesfin Sileshi, Mossie Tamiru, Sara Tomczyk, Fasil Tekola-Ayele, Gail Davey, Amha Fentaye
Podoconiosis is a geochemical disease occurring in individuals exposed to red clay soil of volcanic origin. This Neglected Tropical Disease (NTD) is highly prevalent in Ethiopia. According to the nationwide mapping in 2013, the disease is endemic in 345 districts, where an estimated 35 million people live. The government of Ethiopia prioritized podoconiosis as one of eight priority NTDs and included it in the national integrated master plan for NTDs. An integrated lymphoedema management guideline has been developed...
2017: Ethiopian Medical Journal
https://www.readbyqxmd.com/read/28878428/elimination-of-guinea-worm-disease-in-ethiopia-current-status-of-the-disease-s-eradication-strategies-and-challenges-to-the-end-game
#13
Habtamu Bedimo Beyene, Abyot Bekele, Amanu Shifara, Yehenew A Ebstie, Zelalem Desalegn, Zeyede Kebede, Abate Mulugeta, Kebede Deribe, Zerihun Tadesse, Tamrat Abebe, Biruck Kebede, Getaneh Abrha, Daddi Jima
Dracunculiasis, also named Guinea Worm Disease (GWD), is one of the Neglected Tropical Diseases (NTDs) caused by a parasitic nematode known as Dracunculus medinensis and has been known since antiquity as 'fiery serpent' from Israelites. It is transmitted to humans via drinking contaminated water containing infective copepods. Given, its feasibility for eradication, the Guinea Worm Eradication Program (GWEP) was launched in 1980 with the aim of eradicating the disease. Since its inception, GWEP has made an extraordinary progress in interrupting transmission...
2017: Ethiopian Medical Journal
https://www.readbyqxmd.com/read/28878427/mortality-and-disability-adjusted-life-years-dalys-for-common-neglected-tropical-diseases-in-ethiopia-1990-2015-evidence-from-the-global-burden-of-disease-study-2015
#14
A Deribew, B Kebede, G A Tessema, Y A Adama, A Misganaw, T Gebre, A Hailu, S Biadgilign, A Amberbir, B Desalegn, A A Abajobir, O Shafi, S F Abera, N Negussu, B Mengistu, A T Amare, A Mulugeta, Z Kebede, B Mengistu, Z Tadesse, M Sileshi, M Tamiru, E A Chromwel, S D Glenn, J D Stanaway, K Deribe
INTRODUCTION: Neglected tropical diseases (NTDs) are important public health problems in Ethiopia. In 2013, the Federal Ministry of Health (FMOH) has launched a national NTD master plan to eliminate major NTDs of public health importance by 2020. Benchmarking the current status of NTDs in the country is important to monitor and evaluate the progress in the implementation of interventions and their impacts. Therefore, this study aims to assess the trends of mortality and Disability-adjusted Life-Years (DALY) for the priority NTDs over the last 25 years...
2017: Ethiopian Medical Journal
https://www.readbyqxmd.com/read/28876622/actinomycosis-of-the-foot-a-south-african-case
#15
K E Polden, H Jehle
Mycetoma is a chronic infection, characterised by severe disability and discomfort to patients. This condition is common throughout tropical regions of the world. The Indian subcontinent and north-east Africa, especially Sudan, bear the majority of the disease burden. Due to the limited resources and isolation of these areas, the condition is usually misdiagnosed or incorrectly managed. The World Health Organisation listed the condition as a "neglected disease" in 2013. The creation of the Mycetoma Research Centre (MRC) by the University of Khartoum in 1991 has greatly contributed to the current understanding of this disabling condition...
June 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28870534/assessing-the-insecticide-susceptibility-status-of-field-population-of-phlebotomus-papatasi-diptera-psychodidae-in-a-hyperendemic-area-of-zoonotic-cutaneous-leishmaniasis-in-esfahan-province-central-iran
#16
Leila Shirani-Bidabadi, Alireza Zahraei-Ramazani, Mohammad Reza Yaghoobi-Ershadi, Yavar Rassi, Amir Ahmad Akhavan, Mohammad Ali Oshaghi, Ahmad Ali Enayati, Zahra Saeidi, Reza Jafari, Hassan Vatandoost
Leishmaniasis is a Neglected Tropical Disease (NTD) and emerging parasitic infection that affect mainly poor regions around the world. This study aimed to determine the baseline susceptibility of Phlebotomus papatasi to commonly used insecticides in a hyper endemic area using WHO standard procedure in central Iran. A total of 4-5 replicates containing 120-200 sand flies were used for each insecticide. Baseline susceptibility to DDT and pyrethroids was assessed on 5326 specimens collected from the study area...
September 8, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28864277/neolignans-from-leaves-of-nectandra-leucantha-lauraceae-display-in%C3%A2-vitro-antitrypanosomal-activity-via-plasma-membrane-and-mitochondrial-damages
#17
Simone S Grecco, Thais A Costa-Silva, Gerold Jerz, Fernanda S de Sousa, Vinicius S Londero, Mariana K Galuppo, Marta L Lima, Bruno J Neves, Carolina H Andrade, Andre G Tempone, João Henrique G Lago
Chagas disease is a neglected tropical disease, caused by the protozoan parasite Trypanosoma cruzi, which affects more than eight million people in Tropical and Subtropical countries especially in Latin America. Current treatment is limited to nifurtimox and benznidazole, both with reduced effectiveness and high toxicity. In this work, the n-hexane extract from leaves of Nectandra leucantha (Lauraceae) displayed in vitro antitrypanosomal activity against T. cruzi. Using several chromatographic steps, four related neolignans were isolated and chemically characterized as dehydrodieugenol B (1), 1-(8-propenyl)-3-[3'-methoxy-1'-(8-propenyl)-phenoxy]-4,5-dimethoxybenzene (2), 1-[(7S)-hydroxy-8-propenyl]-3-[3'-methoxy-1'-(8'-propenyl)-phenoxy]-4-hydroxy-5-methoxybenzene (3), and 1-[(7S)-hydroxy-8-propenyl]-3-[3'-methoxy-1'-(8'-propenyl)-phenoxy]-4,5-dimethoxybenzene (4)...
August 31, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28859850/il-4-5-signalling-plays-an-important-role-during-litomosoides-sigmodontis-infection-influencing-both-immune-system-regulation-and-tissue-pathology-in-the-thoracic-cavity
#18
Manuel Ritter, Ruth S Tamadaho, Judith Feid, Wenzel Vogel, Katharina Wiszniewsky, Sven Perner, Achim Hoerauf, Laura E Layland
Approximately 100 million people suffer from filarial diseases including lymphatic filariasis (elephantiasis), onchocerciasis (river blindness) and loiasis. These diseases are amongst the most devastating of the neglected tropical diseases in terms of social and economic impact. Moreover, many infection-induced immune mechanisms in the host, their relationship to disease-related symptoms and the development of pathology within the site of infection remain unclear. To improve on current drug therapies or vaccines, further studies are necessary to decipher the mechanisms behind filaria-driven immune responses and pathology development, and thus the rodent model of Litomosoides sigmodontis can be used to unravel host-filaria interactions...
August 30, 2017: International Journal for Parasitology
https://www.readbyqxmd.com/read/28859088/the-francophone-network-on-neglected-tropical-diseases
#19
Jean Jannin, Philippe Solano, Isadora Quick, Patrice Debre
No abstract text is available yet for this article.
August 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28838305/point-of-care-mobile-digital-microscopy-and-deep-learning-for-the-detection-of-soil-transmitted-helminths-and-schistosoma-haematobium
#20
Oscar Holmström, Nina Linder, Billy Ngasala, Andreas Mårtensson, Ewert Linder, Mikael Lundin, Hannu Moilanen, Antti Suutala, Vinod Diwan, Johan Lundin
BACKGROUND: Microscopy remains the gold standard in the diagnosis of neglected tropical diseases. As resource limited, rural areas often lack laboratory equipment and trained personnel, new diagnostic techniques are needed. Low-cost, point-of-care imaging devices show potential in the diagnosis of these diseases. Novel, digital image analysis algorithms can be utilized to automate sample analysis. OBJECTIVE: Evaluation of the imaging performance of a miniature digital microscopy scanner for the diagnosis of soil-transmitted helminths and Schistosoma haematobium, and training of a deep learning-based image analysis algorithm for automated detection of soil-transmitted helminths in the captured images...
June 2017: Global Health Action
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