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https://www.readbyqxmd.com/read/28095504/cytoplasmic-localization-of-htlv-1-hbz-protein-a-biomarker-of-htlv-1-associated-myelopathy-tropical-spastic-paraparesis-ham-tsp
#1
Marco Baratella, Greta Forlani, Goutham U Raval, Alessandra Tedeschi, Olivier Gout, Antoine Gessain, Giovanna Tosi, Roberto S Accolla
HTLV-1 is the causative agent of a severe form of adult T cell leukemia/Lymphoma (ATL), and of a chronic progressive neuromyelopathy designated HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). Two important HTLV-1-encoded proteins, Tax-1 and HBZ, play crucial roles in the generation and maintenance of the oncogenic process. Less information is instead available on the molecular and cellular mechanisms leading to HAM/TSP. More importantly, no single specific biomarker has been described that unambiguously define the status of HAM/TSP...
January 17, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28093536/noma-overview-of-a-neglected-disease-and-human-rights-violation
#2
REVIEW
M Leila Srour, Klaas Marck, Denise Baratti-Mayer
Noma is an orofacial gangrene affecting malnourished children and mainly observed in tropical countries, particularly sub-Saharan Africa. Epidemiological data on noma are scarce, but a current estimate of the global incidence is 30,000-40,000 cases per year, with a mortality rate of approximately 85% and a burden of disease calculated to be a loss of 1-10 million disability-adjusted life years. The etiology of noma is multifactorial with malnutrition as an ever present factor, often in combination with concomitant diseases, such as measles, malaria, and human immunodeficiency virus (HIV), and poor oral hygiene...
January 16, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28081121/isolation-of-novel-trypanosomatid-zelonia-australiensis-sp-nov-kinetoplastida-trypanosomatidae-provides-support-for-a-gondwanan-origin-of-dixenous-parasitism-in-the-leishmaniinae
#3
Joel Barratt, Alexa Kaufer, Bryce Peters, Douglas Craig, Andrea Lawrence, Tamalee Roberts, Rogan Lee, Gary McAuliffe, Damien Stark, John Ellis
The genus Leishmania includes approximately 53 species, 20 of which cause human leishmaniais; a significant albeit neglected tropical disease. Leishmaniasis has afflicted humans for millennia, but how ancient is Leishmania and where did it arise? These questions have been hotly debated for decades and several theories have been proposed. One theory suggests Leishmania originated in the Palearctic, and dispersed to the New World via the Bering land bridge. Others propose that Leishmania evolved in the Neotropics...
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28070012/prevalence-and-risk-factors-for-intestinal-parasitic-infection-in-schoolchildren-in-battambang-cambodia
#4
Chien-Wei Liao, Kuan-Chih Chiu, I-Chen Chiang, Po-Ching Cheng, Ting-Wu Chuang, Juo-Han Kuo, Yun-Hung Tu, Chia-Kwung Fan
Most intestinal parasitic infections (IPIs), commonly endemic in tropical resource-poor developing countries, are neglected tropical diseases. Parasitic infections and malnutrition are most commonly found in children. We determined the prevalence of IPIs and the risk factors in Battambang Province, northwestern Cambodia, from August to September 2015. This study collected 308 valid questionnaires and specimens from Dontri (173, 56.2%) and Kon Kaêk (135, 43.8%) primary schools. All stool samples were examined using Chang's Feces Examination Apparatus through the merthiolate-iodine-formaldehyde technique...
January 9, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28069074/a-next-generation-microarray-further-reveals-stage-enriched-gene-expression-pattern-in-the-blood-fluke-schistosoma-japonicum
#5
Pengfei Cai, Shuai Liu, Xianyu Piao, Nan Hou, Hong You, Donald P McManus, Qijun Chen
BACKGROUND: Schistosomiasis is caused by infection with blood flukes of the genus Schistosoma, and ranks, in terms of disability-adjusted life years (DALYs), as the third most important neglected tropical disease. Schistosomes have several discrete life stages involving dramatic morphological changes during their development, which require subtle gene expression modulations to complete the complex life-cycle. RESULTS: In the current study, we employed a second generation schistosome DNA chip printed with the most comprehensive probe array for studying the Schistosoma japonicum transcriptome, to explore stage-associated gene expression in different developmental phases of S...
January 10, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28061874/slc11a1-polymorphisms-and-host-susceptibility-to-cutaneous-leishmaniasis-in-pakistan
#6
Mariam Sophie, Abdul Hameed, Akhtar Muneer, Azam J Samdani, Saima Saleem, Abid Azhar
BACKGROUND: The vector-borne cutaneous leishmaniasis (CL) is endemic in several regions of Pakistan mainly affecting poor populations. Host genetic factors, particularly SLC11A1 (solute carrier transmembrane protein) within macrophages, play a crucial role in disease pathology and susceptibility. Association of SLC11A1 with cutaneous leishmaniasis, a neglected tropical disease, is not well established. Inconsistencies have been observed within different populations worldwide with respect to genetic susceptibility...
January 7, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28060841/genomes-of-fasciola-hepatica-from-the-americas-reveal-colonization-with-neorickettsia-endobacteria-related-to-the-agents-of-potomac-horse-and-human-sennetsu-fevers
#7
Samantha N McNulty, Jose F Tort, Gabriel Rinaldi, Kerstin Fischer, Bruce A Rosa, Pablo Smircich, Santiago Fontenla, Young-Jun Choi, Rahul Tyagi, Kymberlie Hallsworth-Pepin, Victoria H Mann, Lakshmi Kammili, Patricia S Latham, Nicolas Dell'Oca, Fernanda Dominguez, Carlos Carmona, Peter U Fischer, Paul J Brindley, Makedonka Mitreva
Food borne trematodes (FBTs) are an assemblage of platyhelminth parasites transmitted through the food chain, four of which are recognized as neglected tropical diseases (NTDs). Fascioliasis stands out among the other NTDs due to its broad and significant impact on both human and animal health, as Fasciola sp., are also considered major pathogens of domestic ruminants. Here we present a reference genome sequence of the common liver fluke, Fasciola hepatica isolated from sheep, complementing previously reported isolate from cattle...
January 6, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28054952/computer-aided-drug-design-using-sesquiterpene-lactones-as-sources-of-new-structures-with-potential-activity-against-infectious-neglected-diseases
#8
REVIEW
Chonny Herrera Acevedo, Luciana Scotti, Mateus Feitosa Alves, Margareth De Fátima Formiga Melo Diniz, Marcus Tullius Scotti
This review presents an survey to the biological importance of sesquiterpene lactones (SLs) in the fight against four infectious neglected tropical diseases (NTDs)-leishmaniasis, schistosomiasis, Chagas disease, and sleeping sickness-as alternatives to the current chemotherapies that display several problems such as low effectiveness, resistance, and high toxicity. Several studies have demonstrated the great potential of some SLs as therapeutic agents for these NTDs and the relationship between the protozoal activities with their chemical structure...
January 3, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28054225/spectrum-and-burden-of-neglected-tropical-diseases-observed-in-an-infectious-and-tropical-diseases-unit-in-florence-italy-2000-2015
#9
Lorenzo Zammarchi, Iacopo Vellere, Leonardo Stella, Filippo Bartalesi, Marianne Strohmeyer, Alessandro Bartoloni
Neglected tropical diseases (NTDs) are a diverse group of acute and chronic conditions with distinct characteristics that thrive mainly among the poorest populations, almost exclusively in tropical countries. To evaluate the relevance and impact of NTDs in a temperate area, the number and features of patients diagnosed with NTDs at the Infectious and Tropical Diseases Unit (ITDU), Azienda Ospedaliero-Universitaria Careggi, Florence, Italy between 2000 and 2015 were retrospectively reviewed. Overall 289 NTD cases were diagnosed in 283 subjects accounting for 2...
January 4, 2017: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/28049483/pterodon-emarginatus-oleoresin-based-nanoemulsion-as-a-promising-tool-for-culex-quinquefasciatus-diptera-culicidae-control
#10
Anna E M F M Oliveira, Jonatas L Duarte, Rodrigo A S Cruz, Raimundo N P Souto, Ricardo M A Ferreira, Taires Peniche, Edemilson C da Conceição, Leandra A R de Oliveira, Silvia M M Faustino, Alexandro C Florentino, José C T Carvalho, Caio P Fernandes
BACKGROUND: Preparation of nanoformulations using natural products as bioactive substances is considered very promising for innovative larvicidal agents. On this context, oil in water nanoemulsions develop a main role, since they satisfactorily disperse poor-water soluble substances, such as herbal oils, in aqueous media. Pterodon emarginatus, popularly known as sucupira, has a promising bioactive oleoresin. However, to our knowledge, no previous studies were carried out to evaluate its potential against Culex quinquefasciatus, the main vector of the tropical neglected disease called lymphatic filariasis or elephantiasis...
January 3, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28043556/antimycobacterial-ingredients-from-plants-used-in-traditional-medicine-to-treat-buruli-ulcer
#11
Patrick Valere Tsouh Fokou, Abena Adomah Kissi-Twum, Dorothy Yeboah-Manu, Regina Appiah-Opong, Phyllis Addo, Lauve Rachel Tchokouaha Yamthe, Alvine Ngoutane Mfopa, Fabrice Fekam Boyom, Alexander Kwadwo Nyarko
AIM AND OBJECTIVES: Buruli ulcer (BU) is a neglected tropical disease caused by a mycobacteria, Mycobacterium ulcerans. The WHO recommended Rifampicin-Streptomycin combination side effects and poor compliance, leaves rural populations with no choice than to patronise indigenous remedies. This study is aimed at validating medicinal plants used in traditional medicine to treat BU by investigating the in vitro efficacy and safety as well as their composition in active molecules. METHODS: A short report-based survey was used to identify medicinal plants used traditionally for BU treatment...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28043490/antimycobacterial-activity-of-medicinal-plants-against-the-causative-agent-of-buruli-ulcer-mycobacterium-ulcerans
#12
R Keumoe, M S Nguembou, F P V Tsouh, D V F Donkeng, D Dize, Y L R Tchokouaha, M C D Jiatsa, F R D Youmsi, B Ngameni, B F Fekam
OBJECTIVE/BACKGROUND: Buruli ulcer, known as necrotizing skin disease caused by Mycobacterium ulcerans, has emerged as the most prevalent mycobacteriosis after leprosy and tuberculosis. Accordingly, it has been classified by the World Health Organization as a neglected disease with high significance in tropical areas, including Cameroon. So far, the control of the disease relies mainly on the rifampin-streptomycin combination. Despite its efficiency, it has shown considerable issues, including availability and side effects...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28042865/the-role-of-natural-products-in-drug-discovery-and-development-against-neglected-tropical-diseases
#13
REVIEW
Peter Mubanga Cheuka, Godfrey Mayoka, Peggoty Mutai, Kelly Chibale
Endemic in 149 tropical and subtropical countries, neglected tropical diseases (NTDs) affect more than 1 billion people annually, including 875 million children in developing economies. These diseases are also responsible for over 500,000 deaths per year and are characterized by long-term disability and severe pain. The impact of the combined NTDs closely rivals that of malaria and tuberculosis. Current treatment options are associated with various limitations including widespread drug resistance, severe adverse effects, lengthy treatment duration, unfavorable toxicity profiles, and complicated drug administration procedures...
December 31, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28036391/naloxonazine-an-amastigote-specific-compound-affects-leishmania-parasites-through-modulation-of-host-encoded-functions
#14
Géraldine De Muylder, Benoit Vanhollebeke, Guy Caljon, Alan R Wolfe, James McKerrow, Jean-Claude Dujardin
Host-directed therapies (HDTs) constitute promising alternatives to traditional therapy that directly targets the pathogen but is often hampered by pathogen resistance. HDT could represent a new treatment strategy for leishmaniasis, a neglected tropical disease caused by the obligate intracellular parasite Leishmania. This protozoan develops exclusively within phagocytic cells, where infection relies on a complex molecular interplay potentially exploitable for drug targets. We previously identified naloxonazine, a compound specifically active against intracellular but not axenic Leishmania donovani...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28033553/volumetric-absorptive-microsampling-vams-as-an-alternative-to-conventional-dried-blood-spots-in-the-quantification-of-miltefosine-in-dried-blood-samples
#15
A E Kip, K C Kiers, H Rosing, J H M Schellens, J H Beijnen, T P C Dorlo
Miltefosine is an oral agent against the neglected tropical disease leishmaniasis, which is mostly endemic in resource-poor areas. Dried blood spot (DBS) sampling is an attractive alternative to plasma sampling for pharmacokinetic studies in these remote areas, but introduces additional variability in analyte quantification due to possible blood spot inhomogeneity and variability in blood spot volume and haematocrit values. Volumetric absorptive microsampling (VAMS) potentially overcomes a few of these issues as the VAMS device absorbs a fixed volume that is processed as a whole...
December 9, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28033343/former-buruli-ulcer-patients-experiences-and-wishes-may-serve-as-a-guide-to-further-improve-buruli-ulcer-management
#16
Anita Velink, Rebecca J Woolley, Richard O Phillips, Kabiru M Abass, Tjip S van der Werf, Emmanuel Agumah, Janine de Zeeuw, Sandor Klis, Ymkje Stienstra
BACKGROUND: Buruli ulcer (BU), caused by Mycobacterium ulcerans, is a neglected tropical disease frequently leading to permanent disabilities. The ulcers are treated with rifampicin and streptomycin, wound care and, if necessary surgical intervention. Professionals have exclusively shaped the research agenda concerning management and control, while patients' perspective on priorities and preferences have not explicitly been explored or addressed. METHODOLOGY/PRINCIPAL FINDINGS: To get insight into patient perception of the management and control of Buruli ulcer a mixed methods research design was applied with a questionnaire and focus group discussions among former BU patients...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28031196/nanotized-curcumin-and-miltefosine-a-potential-combination-for-the-treatment-of-experimental-visceral-leishmaniasis
#17
Brajendra Tiwari, Richa Pahuja, Pradeep Kumar, Srikanth Kumar Rath, Kailash Chand Gupta, Neena Goyal
Leishmaniasis chemotherapy remains very challenging due to high cost of the drug and its associated toxicity and drug resistance which develops over a period of time. Now-a-days combination therapies (CT) are in use for many diseases like cancer and malaria being more effective and affordable than monotherapy. CT is believed to represent a new explorable strategy for leishmaniasis, a neglected tropical disease caused by obligate intracellular parasite Leishmania In the present work, we have adopted a rational approach, to investigate the effect of combination of traditional Indian medicine (Ayurveda), a natural product curcumin and miltefosine, the only oral drug for visceral leishmaniasis (VL) using Leishmania (Leishmania) donovani/hamster model...
December 28, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28030282/the-global-trachoma-mapping-project-a-catalyst-for-progress-against-neglected-tropical-diseases
#18
Dirk Engels
No abstract text is available yet for this article.
2016: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/28027928/dengue-virus-non-structural-protein-1-expression-and-associated-risk-factors-among-febrile-patients-attending-university-of-abuja-teaching-hospital-nigeria
#19
Idris Abdullahi Nasir, Olubunmi Olajide Agbede, Amos Dangana, Marycelin Baba, Abubakar Shehu Haruna
BACKGROUND: Dengue is a mosquito-borne and neglected tropical viral disease that has been reported to be hyper-endemic in Nigeria. However, this is the first dengue study in Abuja. OBJECTIVE: This hospital-based cross-sectional study investigated the prevalence of Dengue virus (DENV) non-structural protein-1 (NS1) antigenaemia, anti-Dengue virus IgG and their associated risk factors among febrile patients attending the University of Abuja Teaching Hospital (UATH), Nigeria...
December 24, 2016: Virus Research
https://www.readbyqxmd.com/read/28025938/trypanothione-reductase-and-superoxide-dismutase-as-current-drug-targets-for-trypanosoma-cruzi-an-overview-of-compounds-with-activity-against-chagas-disease
#20
Iván Beltrán-Hortelano, Silvia Pérez-Silanes, Silvia Galiano
It has been over a century since Carlos Chagas discovered the Trypanosoma cruzi (T. cruzi) as the causative agent of Chagas disease (CD), a neglected tropical disease with several socioeconomic, epidemiological and human health repercussions. Currently, there are only two commercialized drugs to treat CD in acute phase, nifurtimox and benznidazol, with several adverse side effects. Thus, new orally available and safe drugs for this parasitic infection are urgently required. One strategy of great importance in new drug discovery programmes is based on the search of molecules enabling to interfere with enzymes involved in T...
December 26, 2016: Current Medicinal Chemistry
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