Read by QxMD icon Read

Ckd statistical methods

Jongha Park
Cardiovascular (CV) risk assessment is not easy in chronic kidney disease (CKD) patients. Age, male sex, race, family history of CV disease, smoking status and diabetes should be considered as CV risk factors as the general population. It is also accepted that hypertension (HTN) is associated with the greater risk of CV complications in this population. However, there are some concerns in this issue.First, supporting evidence for specific blood pressure (BP) targets in CKD is scarce. Many observational studies reported a J-shaped association between BP level and CV mortality unlike a linear association in the general population...
September 2016: Journal of Hypertension
Jason Roy, Haochang Shou, Dawei Xie, Jesse Y Hsu, Wei Yang, Amanda H Anderson, J Richard Landis, Christopher Jepson, Jiang He, Kathleen D Liu, Chi-Yuan Hsu, Harold I Feldman
Prediction models are often developed in and applied to CKD populations. These models can be used to inform patients and clinicians about the potential risks of disease development or progression. With increasing availability of large datasets from CKD cohorts, there is opportunity to develop better prediction models that will lead to more informed treatment decisions. It is important that prediction modeling be done using appropriate statistical methods to achieve the highest accuracy, while avoiding overfitting and poor calibration...
September 22, 2016: Clinical Journal of the American Society of Nephrology: CJASN
Jongha Park
Cardiovascular (CV) risk assessment is not easy in chronic kidney disease (CKD) patients. Age, male sex, race, family history of CV disease, smoking status and diabetes should be considered as CV risk factors as the general population. It is also accepted that hypertension (HTN) is associated with the greater risk of CV complications in this population. However, there are some concerns in this issue.First, supporting evidence for specific blood pressure (BP) targets in CKD is scarce. Many observational studies reported a J-shaped association between BP level and CV mortality unlike a linear association in the general population...
September 2016: Journal of Hypertension
Yuan Yang, Min Luo, Li Xiao, Xue-Jing Zhu, Chang Wang, Xiao Fu, Shu-Guang Yuan, Fang Xiao, Hong Liu, Zheng Dong, Fu-You Liu, Lin Sun
In the clinic, the pathological types of chronic kidney diseases (CKD) are considered references for choosing treatment protocols. From a statistical viewpoint, a non-invasive method to predict pathological types of CKD is a focus of our work. In the current study, following a frequency analysis of the clinical indices of 588 CKD patients in the department of nephrology, a third-grade class-A hospital, a novel theory is proposed: "bi-directional cumulative probability dichotomy". Further, two models for the prediction and differential diagnosis of CKD pathological type are established...
2016: Scientific Reports
Maoliosa Donald, Kerry McBrien, Wes Jackson, Braden J Manns, Marcello Tonelli, Kathryn King-Shier, Kailash Jindal, Richard Z Lewanczuk, Nairne Scott-Douglas, Ted Braun, Sharon E Straus, Christopher Naugler, Meghan J Elliott, Min Jun, Brenda R Hemmelgarn
BACKGROUND: Primary care physicians and other primary health care professionals from Alberta, Canada identified a clinical pathway as a potential tool to facilitate uptake of clinical practice guidelines for the diagnosis, management and referral of adults with chronic kidney disease. We describe the development and implementation of a chronic kidney disease clinical pathway (CKD-CP; ). METHODS: The CKD-CP was developed and implemented based on the principles of the Knowledge-To-Action Cycle framework...
2016: BMC Medical Informatics and Decision Making
Anna Szymanek-Pasternak, Aleksandra Szymczak, Małgorzata Zalewska, Krzysztof Małyszczak, Brygida Knysz
INTRODUCTION Chronic kidney disease (CKD) is one of the consequences of human immunodeficiency virus-1 (HIV-1) infection. The disease increases the risk of progression to acquired immunodeficiency syndrome and death and complicates antiretroviral therapy. The prevalence of CKD in HIV-1-infected patients is difficult to estimate and depends on the diagnostic criteria for CKD. OBJECTIVES The aim of the study was to evaluate the usefulness of a single measurement of serum asymmetric dimethylarginine (ADMA) levels in the diagnosis of kidney damage in patients infected with HIV-1...
August 18, 2016: Polskie Archiwum Medycyny Wewnętrznej
Vladimir Pushevski, Petar Dejanov, Vesna Gerasimovska, Gordana Petrushevska, Angel Oncevski, Aleksandar Sikole, Zivko Popov, Ninoslav Ivanovski
BACKGROUND: Hemodialysis as an efficient therapy for advanced CKD is the most used treatment modality all over the world. Even though primary AVF is widely accepted as a best permanent vascular access in hemodialysis patients, up to 60% of all fistulas fail to mature. The pathogenesis of early fistula failure is not very well understood. Many general and local factors are involved: patient's age, sex, primary renal disease, small vessel's diameter, presence of accessory veins, prior venipunctures, surgical skill, genetics, etc...
2015: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
Lauren Galbraith, Brenda Hemmelgarn, Braden Manns, Susan Samuel, Joanne Kappel, Nadine Valk, Paul Ronksley
BACKGROUND: Health behaviour change is an important component of management for patients with chronic kidney disease (CKD); however, the optimal method to promote health behaviour change for self-management of CKD is unknown. The See Kidney Disease (SeeKD) targeted screening programme screened Canadians at risk for CKD and promoted health behaviour change through individual counselling and goal setting. OBJECTIVES: The objectives of this study are to determine the effectiveness of individual counselling sessions for eliciting behaviour change and to describe participant characteristics associated with behaviour change...
2016: Canadian Journal of Kidney Health and Disease
Clement Lo, Helena Teede, Dragan Ilic, Grant Russell, Kerry Murphy, Timothy Usherwood, Sanjeeva Ranasinha, Sophia Zoungas
BACKGROUND: Co-morbid diabetes and chronic kidney disease (CKD) are common in primary care but health care can be suboptimal. OBJECTIVE: In this multi-centre mixed-methods study, we investigated GPs' perspectives on health service barriers in managing diabetes and CKD as an initial step towards health care improvement. METHODS: Four focus groups were conducted among GPs in Australia's two largest cities. Transcripts underwent content analysis to inform development of a survey exploring health service barriers...
October 2016: Family Practice
Hironobu Sakaura, Toshitada Miwa, Yusuke Kuroda, Tetsuo Ohwada
OBJECTIVE The authors recently reported that the presence of chronic kidney disease (CKD) and/or extended abdominal aortic calcification was associated with significantly worse clinical outcomes after posterior lumbar interbody fusion. CKD is one of the highest risk factors for systemic atherosclerosis. Therefore, impaired blood flow due to atherosclerosis could exacerbate degeneration of the cervical spine and neural tissue. However, there has been no report of a study evaluating the deleterious effects of CKD and atherosclerosis on the outcomes after decompression surgery for cervical compression myelopathy...
May 27, 2016: Journal of Neurosurgery. Spine
Berkay Ekici, Aslı Tanındı, Irmak Sayın
OBJECTIVE: Chronic kidney disease (CKD) is considered to be one of the most common risk factors for cardiovascular diseases. Glomerular filtration rate (GFR) is the best method of testing level of kidney function and determining stage of kidney disease. The aim of this study was to examine the impact of renal function on severity of coronary heart disease (CHD). METHODS: The present study included 918 patients undergoing elective coronary angiography. GFR was evaluated by simplified Modification of Diet in Renal Disease (MDRD) formula (mL/min/1...
March 2016: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
Willem P Meuwesen, Jesslee M du Plessis, Johanita R Burger, Martie S Lubbe, Marike Cockeran
Background Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used pharmaceutical agents worldwide. NSAIDs are considered nephrotoxic and should therefore be used with caution or be avoided completely in high risk patients, such as chronic kidney disease (CKD) patients. Objective This study aimed to investigate the prescribing of NSAIDs in CKD patients in order to generate awareness and improve the outcome of these patients. Setting The study was conducted using medicine claims data in the private health sector of South Africa...
August 2016: International Journal of Clinical Pharmacy
Pei-Ju Liao, Tzu-Yu Lin, Tzu-Ching Wang, Ming-Kuo Ting, I-Wen Wu, Hsin-Tsung Huang, Fu-Chung Wang, Huan-Cheng Chang, Kuang-Hung Hsu
Chronic kidney disease (CKD) is a major health problem worldwide because of the aging population and lifestyle changes. One of the important etiologies of CKD is diabetes mellitus (DM). The long-term effects of pay-for-performance (P4P) on disease progression have not been thoroughly examined.This study is a retrospective population-based patient cohort design to examine the continuous effects of diabetes and CKD P4P interventions. This study used the health insurance claims database to conduct a longitudinal analysis...
April 2016: Medicine (Baltimore)
Taposh Sarkar, Narinder Pal Singh, Premashish Kar, Syed Akhtar Husain, Seema Kapoor, Sunil Kumar Pollipalli, Anish Kumar, Neena Garg
BACKGROUND: Hypertension is one of the important contributing factors linked with both causation and development of kidney disease. It is a multifactorial, polygenic, and complex disorder due to interaction of several risk genes with environmental factors. The present study was aimed to explore genetic polymorphism in ACE-1 gene as a risk factor for CKD among hypertensive patients. METHODS: Three hundred patients were enrolled in the study. Ninety were hypertensive patients with CKD taken as cases, whereas 210 hypertensive patients without CKD were taken as controls...
June 2016: Renal Failure
Helen Tam-Tham, Brenda Hemmelgarn, David Campbell, Chandra Thomas, Robert Quinn, Karen Fruetel, Kathryn King-Shier
BACKGROUND: Guideline committees have identified the need for research to inform the provision of conservative care for older adults with stage 5 chronic kidney disease (CKD) who have a high burden of comorbidity or functional impairment. We will use both qualitative and quantitative methodologies to provide a comprehensive understanding of barriers and facilitators to care for these patients in primary care. OBJECTIVES: Our objectives are to (1) interview primary care physicians to determine their perspectives of conservative care for older adults with stage 5 CKD and (2) survey primary care physicians to determine the prevalence of key barriers and facilitators to provision of conservative care for older adults with stage 5 CKD...
2016: Canadian Journal of Kidney Health and Disease
José Carlos Arévalo-Lorido, Juana Carretero-Gómez, Francisco García-Sánchez, Enrique Maciá-Botejara, José Manuel Ramiro-Lozano, Antonio Masero-Carretero, Nicolás Roberto Robles, Juan Carlos Bureo-Dacal
AIMS: Secondary hyperparathyroidism (SHPTH) is a leading cause of renal osteodystrophy, and an independent risk factor for all-cause and cardiovascular mortality. Our aim is to establish differences in prevalence and profile of SHPTH, regarding diabetics or non-diabetics with chronic kidney disease (CKD). METHODS: Cross-sectional multicenter study which included patients with stages 3 to 4 CKD. SHPTH was considered when the intact PTH levels (iPTH) were equal or higher than 70pg/ml...
April 2016: Diabetes & Metabolic Syndrome
Dominik Steubl, Marcel Roos, Stefan Hettwer, Robin Satanovskij, Susanne Tholen, Ming Wen, Christoph Schmaderer, Anna-Lena Hasenau, Peter Luppa, Lynne Stecher, Uwe Heemann, Lutz Renders
BACKGROUND: Total C-terminal agrin fragment (tCAF) is a new biomarker that was previously correlated with kidney function. This article studies the validity of tCAF as a biomarker for kidney function in chronic kidney disease (CKD). METHODS: Plasma tCAF, serum creatinine (Cr), cystatin C (CyC), blood urea-nitrogen (BUN) concentrations and estimated glomerular filtration rate (eGFR CKD-EPIcrea-cystatin) were assessed in 426 individuals [71 without CKD (CKD 0°) and 355 CKD patients]...
September 1, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
Qingqing Cai, Xiuying Wang, Jingtao Ye, Lin Zhuo, Hui Song, Chen Liu, Lang Zhuo
BACKGROUND: There is a paucity of literature available as to the relationship between different levels of each metabolic syndrome (MetS) component and decreased GFR. In the present study, we aimed to demonstrate whether MetS always plays a critical role in decreased GFR. METHODS: A cross-sectional study was conducted between February 2010 and September 2012, with 75,468 adults enrolled undergoing measurements of blood pressure as well as tests of blood and urine samples...
2016: Renal Failure
Tiffany Washington, Sheryl Zimmerman, Teri Browne
Chronic kidney disease (CKD) affected 26 million U.S. adults. Many end-stage CKD patients undergoing hemodialysis experience self-management challenges. However, factors associated with CKD self-management are underidentified. This article describes a mixed-methods study to identify factors associated with self-management in end-stage CKD patients undergoing hemodialysis. A total of 107 patients age 50 and older were interviewed. Overall, participants had low mean scores for exercise (2.46), communication with physicians (2...
March 2016: Social Work in Public Health
Ying Chen, Mingzhao Qin, Jie Zheng, Hong Yan, Mei Li, Yao Cui, Ruihua Zhang, Wei Zhao, Ying Guo
The prevalence of chronic kidney disease (CKD) increases with age, and anemia is known to affect the outcome of subjects with CKD. However, little is known with regard to the associations between metabolic complications and stages of CKD among elderly patients. Thus, the aim of the present study was to investigate the prevalence of CKD in elderly Chinese patients, as well as the associations between stages of CKD and clinically important complications of anemia. In total, 2,258 individuals with CKD, divided into younger (n=989) and elderly (n=1,269) groups, were enrolled in the study between June 2009 and December 2011...
August 2015: Experimental and Therapeutic Medicine
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"