Quynh Nhu Dinh, Cecilia Lo, David Wong Zhang, Vivian Tran, Tayla Gibson-Hughes, Ashleigh Sheriff, Henry Diep, Hyun Ah Kim, Shenpeng R Zhang, Liz J Barreto-Arce, Maria Jelinic, Antony Vinh, Thiruma V Arumugam, Siow Teng Chan, Rebecca Lim, Grant R Drummond, Christopher G Sobey, T Michael De Silva
Vascular inflammation and fibrosis are hallmarks of hypertension and contribute to the development of cardiovascular disease and cognitive impairment. However, current anti-hypertensive drugs do not treat the underlying tissue damage, such as inflammation-associated fibrosis. Human amnion epithelial cells have several properties amenable for treating vascular pathology. This study tested the effect of amnion epithelial cells on vascular pathology and cognitive impairment during hypertension. Male C57Bl6 mice (8-12 weeks) were administered vehicle (saline; n = 58) or angiotensin II (0...
January 22, 2024: Scientific Reports