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Exercise-induced hypoalgesia

Kenta Wakaizumi, Takashige Kondo, Yusuke Hamada, Michiko Narita, Rui Kawabe, Hiroki Narita, Moe Watanabe, Shigeki Kato, Emiko Senba, Kazuto Kobayashi, Naoko Kuzumaki, Akihiro Yamanaka, Hiroshi Morisaki, Minoru Narita
BACKGROUND: Exercise alleviates pain and it is a central component of treatment strategy for chronic pain in clinical setting. However, little is known about mechanism of this exercise-induced hypoalgesia. The mesolimbic dopaminergic network plays a role in positive emotions to rewards including motivation and pleasure. Pain negatively modulates these emotions, but appropriate exercise is considered to activate the dopaminergic network. We investigated possible involvement of this network as a mechanism of exercise-induced hypoalgesia...
2016: Molecular Pain
Brandon A Baiamonte, Robert R Kraemer, Chelsea N Chabreck, Matthew L Reynolds, Kayla M McCaleb, Georgia L Shaheen, Daniel B Hollander
Previous research has demonstrated significant decreases in pain perception in healthy individuals following both aerobic and upper body resistance exercise, but research on circuit training has been limited. The purpose of the study was to determine the effects of a strenuous bout of dynamic circuit resistance exercise on pain threshold and pain tolerance in conjunction with changes in blood lactate levels, heart rate (HR), and perceived exertion. A sample of 24 college-age students participated in 2 sessions: (1) a maximal strength testing session and (2) a circuit training bout of exercise that consisted of 3 sets of 12 repetitions with a 1:1 work to rest ratio at 60% one-repetition maximum (1-RM) predicted from a three-repetition maximum (3-RM) for 9 exercises...
October 7, 2016: Journal of Sports Sciences
Stacy Stolzman, Marie Hoeger Bement
PURPOSE: Pain relief after exercise, exercise-induced hypoalgesia (EIH), is established across the lifespan. Conditioned pain modulation (CPM: pain inhibits pain) may be a mechanism for EIH. METHODS: In 55 adolescents, pressure pain thresholds were measured before and after exercise (deltoid, quadriceps, and nail bed) and during CPM at the nail bed and deltoid test stimulus sites. The relationship between EIH and CPM was explored. RESULTS: EIH occurred at deltoid and quadriceps; CPM occurred at nail bed and deltoid...
2016: Pediatric Physical Therapy
Henrik Bjarke Vaegter, Gitte Handberg, Claus Emmeluth, Thomas Graven-Nielsen
OBJECTIVES: Chronic pain after total knee replacement (TKR) is not uncommon. Preoperative impaired conditioning pain modulation (CPM) has been used to predict chronic postoperative pain. Interestingly, exercises reduce pain sensitivity in patients with knee osteoarthritis. This pilot study investigated the association between exercise-induced hypoalgesia (EIH) and CPM on post-TKR pain relief. METHODS: Before and six months post-TKR, 14 patients with chronic knee osteoarthritis performed the cold pressor test on the non-affected leg and two exercise conditions (bicycling and isometric knee extension), randomized and counterbalanced...
August 12, 2016: Clinical Journal of Pain
Caitriona Fingleton, Keith Smart, Catherine Doody
OBJECTIVES: Normal efficiency of exercise-induced hypoalgesia (EIH) has been demonstrated in people with knee osteoarthritis (OA), while recent evidence suggests that EIH may be associated with features of pain sensitization such as abnormal conditioned pain modulation (CPM). The aim of this study was to investigate whether people with knee OA with abnormal CPM have dysfunctional EIH compared to those with normal CPM and pain-free controls. METHODS: 40 people with knee OA were subdivided into groups with abnormal and normal CPM, as determined by a decrease/increase in pressure pain thresholds (PPTs) following the cold pressor test...
August 11, 2016: Clinical Journal of Pain
Katsuya Kami, Fumihiro Tajima, Emiko Senba
Physical exercise, such as forced treadmill running and swimming, can sufficiently improve mechanical allodynia and heat hyperalgesia in animal models of neuropathic pain (NPP), including partial sciatic nerve ligation, chronic constriction injury, and spinal nerve ligation models. Thus, physical exercise has been established as a low-cost, safe, and effective way to manage NPP conditions, but the exact mechanisms underlying such exercise-induced hypoalgesia (EIH) are not fully understood. A growing body of evidence has identified several factors that work at different levels of the nervous system as playing important roles in producing EIH in animal models of NPP...
August 2, 2016: Anatomical Science International
Hannah Gajsar, Christina Titze, Monika Ilona Hasenbring, Henrik Bjarke Vaegter
OBJECTIVE: Isometric exercises produce an acute decrease in the pain sensitivity, known as exercise-induced hypoalgesia (EIH). Existing EIH paradigms use exercises at the extremities with more pronounced EIH at local compared to remote body sites, indicating local inhibition in addition to central inhibitory mechanisms. So far the results on EIH in patients with low back pain (LBP) are equivocal and no studies have investigated an EIH paradigm targeting the lower back in order to assess EIH in patients with LBP...
July 29, 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
Shelbi L Sutterfield, Jamie K Huber, Natalie R Janzen, Christopher D Black
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
Robert R Kraemer, Chelsea N Chabreck, Daniel B Hollander, Brandon A Baiamonte
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
H B Vaegter, M Hoeger Bement, A B Madsen, J Fridriksson, M Dasa, T Graven-Nielsen
BACKGROUND: Exercise causes an acute decrease in the pain sensitivity known as exercise-induced hypoalgesia (EIH), but the specificity to certain pain modalities remains unknown. This study aimed to compare the effect of isometric exercise on the heat and pressure pain sensitivity. METHODS: On three different days, 20 healthy young men performed two submaximal isometric knee extensions (30% maximal voluntary contraction in 3 min) and a control condition (quiet rest)...
June 5, 2016: European Journal of Pain: EJP
K J Lemley, J Senefeld, S K Hunter, M Hoeger Bement
PURPOSE: The perception of pain in response to a noxious stimulus can be markedly reduced following an acute bout of exercise [exercise-induced hypoalgesia (EIH)]. Sex differences in EIH frequently occur after exercise but may be confounded by the sex differences in muscle fatigue. The purpose was to determine if sex differences in pain relief occur after an exercise protocol when muscle fatigue is similar for both young and older men and women. METHODS: Pain perception of 33 men (15 young) and 31 women (19 young) was measured using a pressure pain stimulus on the left index finger before and after maximal velocity concentric contractions of knee extensors or elbow flexors (separate days)...
July 2016: European Journal of Applied Physiology
Christopher D Black, Alexander R Gonglach, Jessica B Renfroe, Robert E Hight
Exercise acutely reduces pain sensitivity, termed exercise-induced hypoalgesia (EIH). The mechanisms underlying EIH remain unclear. Caffeine, a non-specific adenosine receptor antagonist has been shown to attenuate EIH in animals-suggesting the involvement of the adenosinergic system. This pilot study investigated the effects of caffeine on pain sensitivity following cycling exercise in college-aged men. Pressure pain threshold (PPT) and thermal pain threshold (TPT) were assessed in thirteen low caffeine consuming men prior to ingestion of a counter-balanced 5mg·kg(-1) dose of caffeine or a placebo (Pre), 60min following ingestion (Post-In), and then following a 15min bout of cycling exercise (Post-Ex) at an intensity eliciting a quadriceps muscle pain rating of 3 out of 10...
July 1, 2016: Physiology & Behavior
Katsuya Kami, Satoru Taguchi Ms, Fumihiro Tajima, Emiko Senba
BACKGROUND: Physical exercise effectively attenuates neuropathic pain, and multiple events including the inhibition of activated glial cells in the spinal dorsal horn, activation of the descending pain inhibitory system, and reductions in pro-inflammatory cytokines in injured peripheral nerves may contribute to exercise-induced hypoalgesia. Since fewer GABAergic hypoalgesic interneurons exist in the dorsal horn in neuropathic pain model animals, the recovery of impaired GABAergic inhibition in the dorsal horn may improve pain behavior...
2016: Molecular Pain
Kelly M Naugle, Keith E Naugle, Joseph L Riley
UNLABELLED: Laboratory-based studies show that acute aerobic and isometric exercise reduces sensitivity to painful stimuli in young healthy individuals, indicative of a hypoalgesic response. However, little is known regarding the effect of aging on exercise-induced hypoalgesia (EIH). The purpose of this study was to examine age differences in EIH after submaximal isometric exercise and moderate and vigorous aerobic exercise. Healthy older and younger adults completed 1 training session and 4 testing sessions consisting of a submaximal isometric handgrip exercise, vigorous or moderate intensity stationary cycling, or quiet rest (control)...
June 2016: Journal of Pain: Official Journal of the American Pain Society
Katsuya Kami, Satoru Taguchi, Fumihiro Tajima, Emiko Senba
UNLABELLED: Physical exercise can attenuate neuropathic pain (NPP), but the exact mechanism underlying exercise-induced hypoalgesia (EIH) remains unclear. Recent studies have shown that histone hyperacetylation via pharmacological inhibition of histone deacetylases in the spinal cord attenuates NPP, and that histone acetylation may lead to the production of analgesic factors including interleukin 10. We intended to clarify whether histone acetylation in microglia in the spinal dorsal horn contributes to EIH in NPP model mice...
May 2016: Journal of Pain: Official Journal of the American Pain Society
Kevin Kuppens, Filip Struyf, Jo Nijs, Patrick Cras, Erik Fransen, Linda Hermans, Mira Meeus, Nathalie Roussel
BACKGROUND: Professional and pre-professional musicians are characterized by physical and psychological demands inherent to their musical activity, and therefore at risk for developing performance related musculoskeletal pain. Physical and psychological demands are known to influence human pain modulation. OBJECTIVES: In this study we compared the influence of a physically and emotionally stressful task on pain thresholds in musicians with and without shoulder pain...
February 2016: Pain Physician
Henrik B Vaegter, Gitte Handberg, Thomas Graven-Nielsen
OBJECTIVES: In chronic pain patients, impaired conditioned pain modulation (CPM) and exercise-induced hypoalgesia (EIH) have been reported. No studies have compared CPM and EIH in chronic musculoskeletal pain patients with high pain sensitivity (HPS) and low pain sensitivity (LPS). MATERIALS AND METHODS: On 2 days, manual pressure pain thresholds (PPTs) were recorded at the legs, arm, and shoulder in 61 chronic pain patients and they performed the cold pressor test, 2 exercise conditions (bicycling and isometric contraction), and a control condition in a randomized and counterbalanced order...
January 2016: Clinical Journal of Pain
Masataka Umeda, Laura E Kempka, Brennan T Greenlee, Amy C Weatherby
This study compared exercise-induced hypoalgesia (EIH) between African Americans (AAs, n=16) and non-Hispanic Whites (NHWs, n=16), and examined the potential influence of physical activity (PA) on the racial/ethnic difference in EIH. The PA levels were quantified using a questionnaire, and intensity of electrical stimulus to produce moderate pain was individually determined. Participants squeezed a hand dynamometer at 25% of their maximal strength for three minutes, followed by a three-minute post-exercise rest...
January 2016: Biological Psychology
Scott K Stackhouse, Christine M Taylor, Brian J Eckenrode, Erica Stuck, Helen Davey
BACKGROUND: Achilles tendinopathy is a common overuse injury in running and jumping athletes. Currently, we do not understand why some conservative interventions (eg, noxious electrical stimulation and eccentric training) may reduce the pain associated with tendinopathy. OBJECTIVE: To determine whether noxious electrical stimulation (NES) or eccentric contractions would alter pain sensitivity around the asymptomatic Achilles tendon. DESIGN: A double-blind trial with block-randomization by gender into 3 intervention arms: NES, eccentric contractions, or low-intensity cycling...
May 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
Jae Sung Park, Sangri Kim, Ahmet Hoke
Peripheral neuropathy is a major, dose-limiting complication of many chemotherapeutic agents. Currently there is no effective method to prevent development of chemotherapy-induced peripheral neuropathy (CIPN). Recent studies have shown that exercise can improve regeneration of peripheral nerves but its effect in preventing peripheral neuropathy is unknown. In this study, we examined the effect of a rigorous treadmill exercise program that was started 1 week before administration of paclitaxel and continued throughout the study in a mouse model of CIPN...
March 2015: Journal of the Peripheral Nervous System: JPNS
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