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https://www.readbyqxmd.com/read/27925065/natural-canine-infection-by-leishmania-infantum-and-leishmania-amazonensis-and-their-implications-for-disease-control
#1
Letícia da Cruz Sanches, Cleber Costa de Martini, Alex Akira Nakamura, Maria Emília Bodini Santiago, Beatriz Dolabela de Lima, Valéria Marçal Felix de Lima
Leishmaniasis is a major public health problem worldwide. Because Leishmania can adapt to new hosts or vectors, knowledge concerning the current etiological agent in dogs is important in endemic areas. This study aimed to identify the Leishmania species detected in 103 samples of peripheral blood from dogs that were naturally infected with these protozoa. The diagnosis of leishmaniasis was determined through parasitological examination, the indirect enzyme-linked immunosorbent assay (ELISA) and the polymerase chain reaction (PCR)...
December 1, 2016: Revista Brasileira de Parasitologia Veterinária, Brazilian Journal of Veterinary Parasitology
https://www.readbyqxmd.com/read/27925060/hepatozoon-canis-and-leishmania-spp-coinfection-in-dogs-diagnosed-with-visceral-leishmaniasis
#2
Fernanda Nazaré Morgado, Amanda Dos Santos Cavalcanti, Luisa Helena de Miranda, Lúcia Helena O'Dwyer, Maria Regina Lucas da Silva, Rodrigo Caldas Menezes, Aurea Virgínia Andrade da Silva, Mariana Côrtes Boité, Elisa Cupolillo, Renato Porrozzi
This study describes the occurrence of dogs naturally co-infected with Hepatozoon canis and two Leishmania species: L. infantum or L. braziliensis. Four dogs serologically diagnosed with Visceral Leishmaniasis were euthanized. Liver and spleen samples were collected for histopathological analysis and DNA isolation. H. canis meronts were observed in tissues from all four dogs. H. canis infection was confirmed by PCR followed by sequencing of a fragment of 18S rRNA gene. Leishmania detection and typing was confirmed by ITS1' PCR-RFLP and parasite burden was calculated using ssrRNA quantitative qPCR...
December 1, 2016: Revista Brasileira de Parasitologia Veterinária, Brazilian Journal of Veterinary Parasitology
https://www.readbyqxmd.com/read/27922065/detc-based-bacterial-cellulose-bio-curatives-for-topical-treatment-of-cutaneous-leishmaniasis
#3
Fabiana S Celes, Eliane Trovatti, Ricardo Khouri, Johan Van Weyenbergh, Sidney J L Ribeiro, Valeria M Borges, Hernane S Barud, Camila I de Oliveira
The treatment of leishmaniasis still relies on drugs with potentially serious adverse effects. Herein, we tested a topical formulation of bacterial cellulose (BC) membranes containing Diethyldithiocarbamate (DETC), a superoxide dismutase 1 inhibitor. Leishmania-infected macrophages exposed to BC-DETC resulted in parasite killing, without pronounced toxic effects to host cells. This outcome was associated with lower SOD1 activity and higher production of superoxide and cytokine mediators. Topical application of BC-DETC significantly decreased lesion size, parasite load and the inflammatory response at the infection site, as well as the production of both IFN-γ and TNF...
December 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27921993/can-sergentomyia-diptera-psychodidae-play-a-role-in-the-transmission-of-mammal-infecting-leishmania
#4
Carla Maia, Jérôme Depaquit
Leishmaniases are parasitic diseases caused by protozoa of the genus Leishmania. The parasites, which infect various wild and domestic mammals, including humans, are transmitted by the bite of phlebotomine sand flies belonging to the Phlebotomus genus in the Old World and to several genera (including Lutzomyia, Psychodopygus and Nyssomyia) in the New World. In this paper, we consider the genus Sergentomyia as divided into seven subgenera, mainly based on spermathecal morphology: Sergentomyia, Sintonius, Parrotomyia, Rondanomyia, Capensomyia, Vattieromyia and Trouilletomyia...
2016: Parasite: Journal de la Société Française de Parasitologie
https://www.readbyqxmd.com/read/27919688/leishmaniases-in-ecuador-comprehensive-review-and-current-status
#5
REVIEW
Yoshihisa Hashiguchi, Lenin N Velez, Nancy V Villegas, Tatsuyuki Mimori, Eduardo A L Gomez, Hirotomo Kato
This article reviews current knowledge about leishmaniases in Ecuador, proceeding from 1920, when the first human case was described, to the present, mainly focusing on the recent research events published. Regarding basic situations, it appears that 23 of Ecuador's 24 provinces have leishmaniasis-case reports. The disease is one of the mandatory notification infectious diseases in the country since 2005. All the 21,305 cases notified to the Ministry of Public Health, during the period from 2001 through 2014, were said to involve different clinical features of cutaneous leishmaniasis (CL) but not visceral (VL)...
December 2, 2016: Acta Tropica
https://www.readbyqxmd.com/read/27914747/sporothrix-schenckii-sensu-lato-identification-in-fragments-of-skin-lesion-cultured-in-nnn-medium-for-differential-diagnosis-of-cutaneous-leishmaniasis
#6
Liliane de Fátima Antonio, Maria Inês Fernandes Pimentel, Marcelo Rosandiski Lyra, Maria de Fátima Madeira, Luciana de Freitas Campos Miranda, Rodrigo Almeida Paes, Fábio Brito-Santos, Maria Helena Galdino Figueredo Carvalho, Armando de Oliveira Schubach
Eighty-nine patients with clinical suspicion of leishmaniasis were referred for differential diagnosis. Sporothrix schenckii sensu lato was isolated in Novy-MacNeal-Nicolle + Schneider media in 98% of 64 patients with final diagnosis of sporotrichosis. This medium may be suitable for diagnosis of sporotrichosis in areas where cutaneous leishmaniasis is also endemic.
November 15, 2016: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/27914666/reprint-of-spatial-modeling-of-cutaneous-leishmaniasis-in-iran-from-1983-to-2013
#7
Kourosh Holakouie-Naieni, Ehsan Mostafavi, Ali Darvishi Boloorani, Mehdi Mohebali, Reza Pakzad
INTRODUCTION: Cutaneous Leshmaniasis (CL), a parasitic skin infection caused by Leishmania species, is endemic in some regions of Iran. In this study, the effect of location on the incidence and distribution of CL in Iran was studied. METHODS: We collected datas including the number of Cutaneous Leishmaniasis cases and populations at-risk of disease in Iran's different provinces reported by the Iranian ministry of health and the National Bureau of Statistics, respectively...
November 30, 2016: Acta Tropica
https://www.readbyqxmd.com/read/27911896/different-mutations-in-a-p-type-atpase-transporter-in-leishmania-parasites-are-associated-with-cross-resistance-to-two-leading-drugs-by-distinct-mechanisms
#8
Christopher Fernandez-Prada, Isabel M Vincent, Marie-Christine Brotherton, Mathew Roberts, Gaétan Roy, Luis Rivas, Philippe Leprohon, Terry K Smith, Marc Ouellette
Leishmania infantum is an etiological agent of the life-threatening visceral form of leishmaniasis. Liposomal amphotericin B (AmB) followed by a short administration of miltefosine (MF) is a drug combination effective for treating visceral leishmaniasis in endemic regions of India. Resistance to MF can be due to point mutations in the miltefosine transporter (MT). Here we show that mutations in MT are also observed in Leishmania AmB-resistant mutants. The MF-induced MT mutations, but not the AmB induced mutations in MT, alter the translocation/uptake of MF...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27910105/molecular-screening-of-leishmania-spp-infection-and-bloodmeals-in-sandflies-from-a-leishmaniasis-focus-in-southwestern-turkey
#9
M Karaku Ş, M Pekağ Irba Ş, S Demir, H Eren, S Töz, Y Özbel
Leishmaniasis is an arthropod-borne disease that affects approximately 2 million people worldwide annually. The aims of this study were to detect the presence of Leishmania (Kinetoplastida: Trypanosomatidae) DNA and the feeding preferences of probable vector species in an endemic focus of Leishmania infantum in Turkey. Entomological sampling was performed in August and October 2015 in Aydın province, where cases of human and canine leishmaniasis have been reported previously. A total of 1059 sandfly specimens comprising nine species belonging to two genera, Phlebotomus and Sergentomyia (both: Diptera: Psychodidae), and five subgenera of the Phlebotomus genus (Phlebotomus, Paraphlebotomus, Larroussius, Adlerius and Transphlebotomus) were collected in five villages...
December 2, 2016: Medical and Veterinary Entomology
https://www.readbyqxmd.com/read/27907136/immune-activation-and-bacterial-translocation-a-link-between-impaired-immune-recovery-and-frequent-visceral-leishmaniasis-relapses-in-hiv-infected-patients
#10
Maria Luciana Silva-Freitas, Glaucia Fernandes Cota, Talia S Machado-de-Assis, Carmem Giacoia-Gripp, Ana Rabello, Alda M Da-Cruz, Joanna R Santos-Oliveira
The maintenance of chronic immune activation due to leishmaniasis or even due to microbial translocation is associated with immunosenescence and may contribute to frequent relapses. Our aim was to investigate whether patients with HIV-associated visceral leishmaniasis (VL/HIV) who experience a single episode of VL have different immunological behaviors in comparison to those who experience frequent relapses. VL/HIV patients were allocated to non-relapsing (NR, n = 6) and relapsing (R, n = 11) groups and were followed from the active phase of VL up to 12 months post-treatment (mpt)...
2016: PloS One
https://www.readbyqxmd.com/read/27906988/atypical-manifestations-of-cutaneous-leishmaniasis-in-a-region-endemic-for-leishmania-braziliensis-clinical-immunological-and-parasitological-aspects
#11
Luiz Henrique Guimarães, Adriano Queiroz, Juliana A Silva, Silvana C Silva, Viviane Magalhães, Ednaldo L Lago, Paulo Roberto L Machado, Olívia Bacellar, Mary E Wilson, Stephen M Beverley, Edgar M Carvalho, Albert Schriefer
BACKGROUND: Atypical cutaneous leishmaniasis (ACL) has become progressively more frequent in Corte de Pedra, Northeast Brazil. Herein we characterize clinical presentation, antimony response, cytokine production and parasite strains prevailing in ACL. METHODOLOGY/PRINCIPAL FINDINGS: Between 2005 and 2012, 51 ACL (cases) and 51 temporally matched cutaneous leishmaniasis (CL) subjects (controls) were enrolled and followed over time in Corte de Pedra. Clinical and therapeutic data were recorded for all subjects...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27906059/a-mitochondrial-hsp70-hspa9b-is-linked-to-miltefosine-resistance-and-stress-response-in-leishmania-donovani
#12
P Vacchina, B Norris-Mullins, E S Carlson, M A Morales
BACKGROUND: Protozoan parasites of the genus Leishmania are responsible for leishmaniasis, a neglected tropical disease affecting millions worldwide. Visceral leishmaniasis (VL), caused by Leishmania donovani, is the most severe form of leishmaniasis with high rates of mortality if left untreated. Current treatments include pentavalent antimonials and amphotericin B. However, high toxicity and emergence of resistance hinder the success of these options. Miltefosine (HePC) is the first oral treatment available for leishmaniasis...
December 1, 2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27905639/-knowledge-of-leishmania-spp-and-leishmaniasis-in-medical-students-in-latin-america-2016
#13
Carlos Rios-González, Jessica Flores, Manuel Calvopiña
No abstract text is available yet for this article.
August 2016: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/27905287/hemophagocytic-syndrome-due-to-leishmania-infection-diagnosed-with-immunofluorescence-antibody-test
#14
Hakan Sarbay, Yasemin Işık Balcı, Selin Güler, Meral Türk, Mehmet Akın, Aziz Polat
Leishmaniasis is a reticuloendothelial system disease that mostly observed before the age of 5. Visceral infection causes long-standing fever, weight loss, weakness, pancytopenia, and hepatosplenomegaly. Leishmania infantum is responsible for visceral leishmaniasis (VL) in Turkey. We present a case of hemophagocytic syndrome due to Leishmania infection diagnosed with an immunofluorescence antibody test (IFAT). Leishmania amastigotes were not observed on bone marrow aspiration. We consider that IFAT is very important for parasite detection in the diagnosis of VL in children, particularly when amastigotes are not obtained on bone marrow aspiration...
September 2016: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/27905279/cloning-of-the-dna-vaccine-candidate-lack-gene-of-leishmania-infantum
#15
Serkan Karaca, Şirin Sahra Ceylan, Süleyman Yazar, Salih Kuk
OBJECTIVE: Leishmaniasis is caused by an obligate intracellular protozoa belonging to Leishmania genus and listed among major tropical diseases by WHO. Because of the high costs, toxicity, and adverse effects of routinely used compounds in the treatment, alternative treatment and vaccine studies are underway. An effective vaccine has not been developed to date. In this study, we aimed to clone one of the most promising DNA vaccine candidates: the homolog-activated C kinase (LACK) gene of Leishmania infantum...
September 2016: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/27905278/seroprevalence-of-canine-leishmaniasis-in-northern-cyprus
#16
Tayfun Çanakçı, Arif Kurtdede, Serdar Paşa, Seray Töz Özensoy, Yusuf Özbel
OBJECTIVE: Canine leishmaniasis (CanL) is an important public and veterinary health problem in Mediterranean Basin countries. In this study, we aimed to determine the seroprevalence of CanL in several provinces of Northern Cyprus. METHODS: The seroprevalence of CanL was determined by the indirect fluorescent antibody (IFA) test in dog sera. In total, 281 dogs were randomly selected from Nicosia (n=80), Trikomo (n=58), Famagusta (n=60), Morphou (n=30), and Kyrenia (n=53), consistent with a statistically representative number of the regional dog population...
September 2016: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/27903308/joint-spatial-time-series-epidemiological-analysis-of-malaria-and-cutaneous-leishmaniasis-infection
#17
O A Adegboye, M Al-Saghir, D H Y Leung
Malaria and leishmaniasis are among the two most important health problems of many developing countries especially in the Middle East and North Africa. It is common for vector-borne infectious diseases to have similar hotspots which may be attributed to the overlapping ecological distribution of the vector. Hotspot analyses were conducted to simultaneously detect the location of local hotspots and test their statistical significance. Spatial scan statistics were used to detect and test hotspots of malaria and cutaneous leishmaniasis (CL) in Afghanistan in 2009...
December 1, 2016: Epidemiology and Infection
https://www.readbyqxmd.com/read/27899126/new-epidemiological-aspects-of-visceral-and-cutaneous-leishmaniasis-in-taza-morocco
#18
Maryam Hakkour, Asmae Hmamouch, Mohamed Mahmoud El Alem, Abdelkbir Rhalem, Fatima Amarir, Mohamed Touzani, Abderrahim Sadak, Hajiba Fellah, Faiza Sebti
BACKGROUND: Leishmaniasis is considered among the main endemic diseases in Morocco. However, further knowledge about epidemiological aspects of this disease is needed in several provinces to plan control and preventive strategies to tackle the disease. The present study aims to determine the epidemiological aspect of cutaneous and visceral leishmaniasis in Taza Province from 2007-2014 and to identify the circulating species in this province. RESULTS: The temporal study from 2007 to 2014 showed that the number of cutaneous leishmaniasis cases increased since 2010...
November 29, 2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27898671/prevalence-of-cutaneous-leishmaniasis-in-districts-of-high-and-low-endemicity-in-mali
#19
Bourama Traoré, Fabiano Oliveira, Ousmane Faye, Adama Dicko, Cheick A Coulibaly, Ibrahim M Sissoko, Samake Sibiry, Nafomon Sogoba, Moussa Brema Sangare, Yaya I Coulibaly, Pierre Traore, Sekou F Traore, Jennifer M Anderson, Somita Keita, Jesus G Valenzuela, Shaden Kamhawi, Seydou Doumbia
Historically the western sahelian dry regions of Mali are known to be highly endemic for cutaneous leishmaniasis (CL) caused by Leishmania major, while cases are rarely reported from the Southern savanna forest of the country. Here, we report baseline prevalence of CL infection in 3 ecologically distinct districts of Mali (dry sahelian, north savanna and southern savanna forest areas). We screened 195 to 250 subjects from 50 to 60 randomly selected households in each of the 6 villages (four from the western sahelian district of Diema in Kayes region, one from the central district of Kolokani and one from the southern savanna district of Kolodieba, region of Sikasso)...
November 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27896890/diterpenes-as-lead-molecules-against-neglected-tropical-diseases
#20
REVIEW
Marcus Vinícius Oliveira Barros de Alencar, João Marcelo de Castro E Sousa, Hercília Maria Lins Rolim, Maria das Graças Freire de Medeiros, Gilberto Santos Cerqueira, Fernanda Regina de Castro Almeida, Antônia Maria das Graças Lopes Citó, Paulo Michel Pinheiro Ferreira, José Arimatéia Dantas Lopes, Ana Amélia de Carvalho Melo-Cavalcante, Md Torequl Islam
Nowadays, neglected tropical diseases (NTDs) are reported to be present everywhere. Poor and developing areas in the world have received great attention to NTDs. Drug resistance, safety profile, and various challenges stimulate the search for alternative medications. Plant-based drugs are viewed with great interest, as they are believed to be devoid of side effects. Diterpenes, a family of essential oils, have showed attractive biological effects. A systematic review of the literature was carried out to summarize available evidences of diterpenes against NTDs...
November 29, 2016: Phytotherapy Research: PTR
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