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Francis Combes, Séan Mc Cafferty, Evelyne Meyer, Niek N Sanders
Solid tumors frequently coexist with a degree of local chronic inflammation. Recruited myeloid cells can therefore be considered as interesting vehicles for tumor-targeted delivery of therapeutic agents. Using in vivo imaging, the short-term accumulation of systemically injected monocytes, macrophages and myeloid-derived suppressor cells (MDSCs) was compared in mice bearing fat pad mammary carcinomas. Monocytes and macrophages demonstrated almost identical in vivo and ex vivo distribution patterns with maximal tumor-associated accumulation seen 48 hours after injection that remained stable over the 4-day follow-up period...
July 16, 2018: Neoplasia: An International Journal for Oncology Research
Lee O Morgan, Marty Johnson, Jered Cornelison, Carolyn Isaac, Joyce deJong, Joseph A Prahlow
Postmortem fingerprint collection is a routine part of many forensic death investigations. Although the production of postmortem prints is usually straight forward, several obstacles and scenarios can make the collection difficult. A common challenge occurs when finger pads are mummified. Several current techniques allow for softening and rehydration of mummified finger pads; however, despite the employment of such techniques, the production of adequate postmortem fingerprints can remain elusive. The authors present two techniques that can improve the chances of obtaining suitable fingerprints from mummified remains...
July 19, 2018: Journal of Forensic Sciences
Akram Saleh, Hanna Makhamreh, Tareq Qoussoos, Izzat Alawwa, Moath Alsmady, Zaid A Salah, Ali Shakhatreh, Lewa Alhazaymeh, Mohammed Jabber
Coronary artery disease (CAD) and peripheral arterial disease (PAD) are serious manifestations of systemic atherosclerosis. A considerable proportion of patients with CAD have associated PAD; however, many are asymptomatic and this condition remains underdiagnosed. Little is known about the prevalence and clinical implication of PAD in patients undergoing coronary angiography in the Middle East with no history of the disease.To study the prevalence of previously unrecognized PAD of the lower limbs in patients undergoing coronary angiography, and to determine the correlation with CAD...
July 2018: Medicine (Baltimore)
Thomas K Pellinger, Catherine B Neighbors, Grant H Simmons
BACKGROUND/OBJECTIVE: In this pilot study, we tested the hypothesis that acute lower leg heating (LLH) increases postheating popliteal artery blood flow and 6-minute walk distance in patients with peripheral artery disease (PAD). METHODS: Six patients (5 male, 1 female) with PAD (69 ± 6.9 years; claudication: ankle-brachial index < 0.90) participated in 3 randomized treatment sessions (2-7 days apart): control or bilateral LLH conducted via water bath immersion (42°C; ~40-cm depth) for either 15 or 45 minutes...
July 18, 2018: Journal of Cardiovascular Nursing
Natsuko Kakudo, Naoki Morimoto, Takeshi Ogawa, Shigeru Taketani, Kenji Kusumoto
Fibroblast growth factor (FGF)-2 induces mitogenesis, angiogenesis and adipogenesis. In this study, the adipogenesis-inducing effects of FGF-2 combined with bilayer artificial dermis in mice were evaluated. FGF-2-impregnated bilayer artificial dermis composed of collagen matrix, PELNAC (Gunze Corp., Osaka, Japan) was implanted subcutaneously into the thoracic region of mice. At 1, 2, 3, and 4 weeks, samples were collected for H&E staining, von Willebrand factor immunostaining, and perilipin immunostaining to examine adipose tissue localization and angiogenesis...
July 18, 2018: Medical Molecular Morphology
Aaron W Aday, Patrick R Lawler, Nancy R Cook, Paul M Ridker, Samia Mora, Aruna D Pradhan
Background -Despite strong and consistent prospective associations of elevated low-density lipoprotein-cholesterol (LDL-C) concentration with incident coronary and cerebrovascular disease (CCVD), data for incident peripheral artery disease (PAD) are less robust. Atherogenic dyslipidemia characterized by increased small LDL particle concentration (LDL-P), rather than total LDL cholesterol content, along with elevated triglyceride-rich lipoproteins and low high-density lipoprotein-cholesterol (HDL-C) may be the primary lipid driver of PAD risk...
July 18, 2018: Circulation
Fuyuan Liao, Ruopeng An, Fang Pu, Stephanie Burns, Sa Shen, Yih-Kuen Jan
The objectives of this study were to examine the effectiveness of different types of exercise on risk factors of diabetic foot ulcers, including glycated hemoglobin (HbA1c), peripheral arterial disease (PAD), and diabetic peripheral neuropathy, in people with type 2 diabetes mellitus (T2DM). PubMed, Web of Science, Cochrane Library, Scopus, and CINAHL were searched from inception to January 2018 for relevant articles. Eligible studies were randomized controlled trials (RCTs) that examined effects of exercise on the selected risk factors...
July 16, 2018: American Journal of Physical Medicine & Rehabilitation
A Darr, K Jolly, T Martin, A Monaghan, P Grime, M Isles, T Beech, S Ahmed
No abstract text is available yet for this article.
July 12, 2018: British Journal of Oral & Maxillofacial Surgery
Jonathan Golledge, Khyber Maarij, Joseph V Moxon, Jonathan D Beard, Sebastien Girold, Hans Wrang, Dylan R Morris
OBJECTIVES: An exercise programme is part of the initial management of peripheral artery disease (PAD). Nordic walking uses poles and a core-focused walking technique to reduce the load on the legs, which may have advantages as an exercise programme for PAD. This systematic review examined the benefit of a Nordic walking programme for treating PAD compared with other programmes. METHODS: A systematic approach was used to identify clinical trials comparing Nordic walking and control programmes in PAD patients...
July 12, 2018: European Journal of Vascular and Endovascular Surgery
Kenneth J Salleng, Carissa P Jones, Kelli L Boyd, Donna J Hicks, Michelle M Williams, Rebecca S Cook
Female nude mice (J:NU-Foxn1nu; age, 6 wk) were injected with 1 million MCF7 human breast cancer cells in the fourth mammary fat pads and received a 21-d sustained-release estrogen pellet (0.25 mg) subcutaneously in the dorsum of the neck. All mice were maintained in sterile housing and provided sterile water and irradiated rodent chow. Approximately 6 wk after implantation, 4 of the 30 mice showed clinical signs of depression and dehydration. The 2 animals most severely affected were euthanized and presented for necropsy...
July 17, 2018: Comparative Medicine
Joachim Dissemond, Thomas Eberlein, Anke Bültemann, Gunnar Riepe, Ingo Stoffels, Jackie Stephen-Haynes, Claas Roes, Abel Martin
OBJECTIVE: Effective and comfortable debridement is an important part of managing complex wounds. This user test evaluated a monofilament-fibre pad (with handle) (Debrisoft Lolly, Lohmann & Rauscher GmbH & Co. KG) in the debridement of various hard-to-reach wounds. METHOD: The multicentre, international user test was performed by experienced physicians and nurses in Germany and the UK, who used the monofilament-fibre pad in their clinical practice. After debridement, using the monofilament-fibre pad, the clinicians completed an evaluation questionnaire...
July 2, 2018: Journal of Wound Care
Mitsunori Kaya, Masashi Fujii, Yosuke Iwamoto, Itsuki Nagahata
Groin pain is a common problem that is known to be a complex issue. The wide variety of possible pathologies in numerous anatomical structures contributes to this complexity. For patients who have anterior hip pain in Patrick's test and tenderness at Scarpa's triangle, we perform periarticular debridement based on the hypothesis that rectus femoris tendinosis, subacute/chronic fibrosis of the anterior inferior iliac spine fat pad, and gluteal muscle adhesion are responsible for such anterior hip pain. This Technical note illustrates the surgical procedure of periarticular debridement for extra-articular pathology-associated anterior hip pain...
June 2018: Arthroscopy Techniques
Elise Kaplan, Nicholas P Greene, Allister Crow, Vassilis Koronakis
In Gram-negative bacteria, outer-membrane lipoproteins are essential for maintaining cellular integrity, transporting nutrients, establishing infections, and promoting the formation of biofilms. The LolCDE ABC transporter, LolA chaperone, and LolB outer-membrane receptor form an essential system for transporting newly matured lipoproteins from the outer leaflet of the cytoplasmic membrane to the innermost leaflet of the outer membrane. Here, we present a crystal structure of LolA in complex with the periplasmic domain of LolC...
July 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
Kumar Perinbam, Albert Siryaporn
Traditional bacterial virulence assays involve prolonged exposure of bacteria over the course of several hours to host cells. During this time, bacteria can undergo changes in the physiology due to the exposure to host growth environment and the presence of the host cells. We developed an assay to rapidly measure the virulence state of bacteria that minimize the extent to which bacteria grow in the presence of host cells. Bacteria and amoebae are mixed together and immobilized on a single imaging plane using an agar pad...
June 27, 2018: Journal of Visualized Experiments: JoVE
Wei Liu, Xing Lv, Wenhua Huang, Wenbing Yao, Xiangdong Gao
A neutral polysaccharide coded as CERP1 was extracted and purified from the residue of Codonopsis pilosula by ethanol precipitation and column chromatography. The structure of CERP1 was determined by HPAEC-PAD, HPLC, HPSEC-MALLS, FT-IR, NMR, and TEM. The results showed that CERP1 was a heteropolysaccharide composed of Arabinose, Glucose, and Galactose in the ratio of 1.00:19.83:6.94. HPSEC-MALLS showed that CERP1 was homogeneous with an absolute molecular weight of 4.840 × 103  Da. The NMR results and the GC-MS result of methylation indicated that 1-linked β-d-glucose, 1,3-linked β-d-glucose, 1,6-linked β-d-glucose and 1,3,6-linked β-d-galactose were the main linkages in CERP1...
October 1, 2018: Carbohydrate Polymers
Stephanie E Dreifuss, Danielle Minteer, Beth R Gusenoff, Jeffrey A Gusenoff
Background: Pedal fat grafting is a cosmetic procedure indicated to treat the functional and aesthetic sequelae of pedal fat pad atrophy. Fat grafting has been found to mitigate these symptoms, but the exact mechanism is unknown. Objectives: We hypothesize that pedal fat grafting may improve skin quality, accounting for prolonged symptomatic improvement despite loss of grafted fat. Methods: Patients with pedal atrophy were enrolled in a randomized crossover clinical trial...
July 10, 2018: Aesthetic Surgery Journal
Maxim J McKibben, Nabeel Shakir, Joceline S Fuchs, Jeremy M Scott, Allen F Morey
INTRODUCTION AND OBJECTIVES: To compare long term outcomes and erosion rates of 3.5 cm artificial urinary sphincter (AUS) cuffs versus larger cuffs among men with stress urinary incontinence (SUI), with and without a history of pelvic radiation. MATERIALS AND METHODS: We reviewed the records of all men who underwent AUS placement by a single surgeon between September 2009 and June 2017 at our tertiary urban medical center. A uniform perineal approach was used to ensure cuff placement around the most proximal corpus spongiosum after precise spongiosal measurement...
July 14, 2018: BJU International
Gabriel Ogaya-Pinies, Estefania Linares-Espinos, Eduardo Hernandez-Cardona, Cathy Jenson, Xavier Cathelineau, Rafael Sanchez-Salas, Vipul Patel
INTRODUCTION: While no consensus on the optimal salvage treatment exists, only 3% of these patients will get salvage radical prostatectomies due to the assumed technical challenges of this procedure. OBJECTIVES: Our goal is to analyze the perioperative, oncologic and functional outcomes of patients undergoing salvage robotic-assisted radical prostatectomy (sRARP) after primary treatment failure. MATERIALS AND METHODS: Data were prospectively collected and retrospectively reviewed from a combined database of more than 14,800 patients who had undergone RARP...
July 13, 2018: World Journal of Urology
Cristian M Moreira, Sirley V Pereira, Julio Raba, Franco A Bertolino, Germán A Messina
INTRODUCTION: The PKU is an inborn error of amino acid metabolism, in which phenylalanine (Phe) accumulated in the blood causing alterations at the central nervous system. We report a novel paper-based enzymatic platform coupled to screen printed graphene-modified electrode for the neonatal screening of phenylketonuria (PKU0. METHODS: The paper-based analytical device coupled to electrochemical detection (EPAD) is based on the use of paper microzones modified with phenylalanine dehydrogenase enzyme (PheDH)...
July 10, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
Aparna Shinde, Tomasz Wilmanski, Hao Chen, Dorothy Teegarden, Michael K Wendt
BACKGROUND: Overcoming systemic dormancy and initiating secondary tumor grow under unique microenvironmental conditions is a major rate-limiting step in metastatic progression. Disseminated tumor cells encounter major changes in nutrient supplies and oxidative stresses compared to the primary tumor and must demonstrate significant metabolic plasticity to adapt to specific metastatic sites. Recent studies suggest that differential utilization of pyruvate sits as a critical node in determining the organotropism of metastatic breast cancer...
July 13, 2018: Breast Cancer Research: BCR
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