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https://www.readbyqxmd.com/read/28944439/hyperintense-signal-alteration-in-the-suprapatellar-fat-pad-on-mri-is-associated-with-degeneration-of-the-patellofemoral-joint-over-48%C3%A2-months-data-from-the-osteoarthritis-initiative
#1
Benedikt J Schwaiger, John Mbapte Wamba, Alexandra S Gersing, Michael C Nevitt, Luca Facchetti, Charles E McCulloch, Thomas M Link
OBJECTIVE: To analyze associations of suprapatellar fat pad (SPFP) hyperintense signal alterations and mass effect with progression of patellofemoral osteoarthritis (OA) and clinical symptoms over 48 months. MATERIALS AND METHODS: Subjects from the Osteoarthritis Initiative (n = 426; 51.8 ± 3.8 years; 49.8% women) without radiographic tibiofemoral OA underwent 3T-MRI of their right knees and clinical evaluation using the Knee Injury and Osteoarthritis Outcome Score at baseline and at 48 months...
September 24, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28944088/loss-of-the-vitamin-d-receptor-in-human-breast-and-prostate-cancers-strongly-induces-cell-apoptosis-through-downregulation-of-wnt-%C3%AE-catenin-signaling
#2
Yu Zheng, Trupti Trivedi, Ruby Cy Lin, Colette Fong-Yee, Rick Nolte, Jeline Manibo, Yunzhao Chen, Musharraf Hossain, Konstantin Horas, Colin Dunstan, Hong Zhou, Markus J Seibel
Vitamin D co-regulates cell proliferation, differentiation and apoptosis in numerous tissues, including cancers. The known anti-proliferative and pro-apoptotic actions of the active metabolite of vitamin D, 1,25-dihydroxy-vitamin D [1,25(OH)2D] are mediated through binding to the vitamin D receptor (VDR). Here, we report on the unexpected finding that stable knockdown of VDR expression in the human breast and prostate cancer cell lines, MDA-MB-231 and PC3, strongly induces cell apoptosis and inhibits cell proliferation in vitro...
2017: Bone Research
https://www.readbyqxmd.com/read/28943994/preservation-of-the-sterile-matrix-hyponychium-and-fingertip-pad-in-fingertip-reconstruction-with-composite-fingertip-and-nail-bed-graft-and-volar-v-y-advancement-flap
#3
Joshua T Henderson, Steven A Schulz, Andrew M Swiergosz, Andrea R Hiller, J Stephen Gunn, Joshua H Choo, Morton L Kasdan, Bradon J Wilhelmi
Background: The goals of fingertip reconstruction are to achieve adequate soft-tissue coverage and a functional nail plate and to maintain sensation, proprioception, and cosmesis. Objective: We present a composite tissue graft and volar V-Y advancement flap for reconstruction of a traumatic amputation of a fingertip, which provided optimal preservation of the hyponychium and the volar pad for prevention of a hook nail. Historically, composite fingertip grafts have not been recommended for adults with large defects...
2017: Eplasty
https://www.readbyqxmd.com/read/28943074/local-protocol-variations-for-image-guided-radiation-therapy-in-the-multicenter-dutch-hypofractionation-hypro-trial-impact-of-rectal-balloon-and-mri-delineation-on-anorectal-dose-and-gastrointestinal-toxicity-levels
#4
R C Wortel, W D Heemsbergen, R J Smeenk, M G Witte, A D Krol, F J Pos, L Incrocci
PURPOSE: The phase 3 HYpofractionated irradiation for PROstate cancer (HYPRO) trial randomized patients with intermediate- to high-risk localized prostate cancer to conventionally fractionated (78 Gy in 39 fractions) or hypofractionated (64.6 Gy in 19 fractions) radiation therapy. Differences in techniques and treatment protocols were present between participating centers. This study aimed to compare dose parameters and patient-reported gastrointestinal symptoms between these centers...
August 3, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28941286/manual-function-and-performance-in-humans-gorillas-and-orangutans-during-the-same-tool-use-task
#5
Ameline Bardo, Raphaël Cornette, Antony Borel, Emmanuelle Pouydebat
OBJECTIVES: Humans are known to possess more complex manual abilities than other primates. However, the manual abilities of primates have not been fully explored, and we still do not know if the manipulative abilities we attribute to humans are unique. The aim of this study was to compare the manual function and performance developed by humans, gorillas and orangutans while performing the same experimental tool use task. MATERIALS AND METHODS: The study was conducted on 20 humans, 6 gorillas, and 7 orangutans...
September 23, 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28940342/physician-assisted-death-and-severe-treatment-resistant-depression
#6
Bonnie Steinbock
Should people suffering from untreatable psychiatric conditions be eligible for physician-assisted death? This is possible in Belgium and the Netherlands, where PAD for psychiatric conditions is permitted, though rare, so long as the criteria of due care are met. Those opposed to all instances of PAD point to Belgium and the Netherlands as a dark warning that once PAD is legalized, restricting it will prove impossible because safeguards, such as the requirement that a patient be terminally ill, will inevitably be eroded or discarded...
September 2017: Hastings Center Report
https://www.readbyqxmd.com/read/28940030/establishing-and-monitoring-of-urethral-sphincter-deficiency-in-a-large-animal-model
#7
Alexandra Kelp, Anika Albrecht, Bastian Amend, Mario Klünder, Philipp Rapp, Oliver Sawodny, Arnulf Stenzl, Wilhelm K Aicher
BACKGROUND: Different methods for induction and monitoring of urethral sphincter deficiency were explored in a large animal model. METHODS: Sphincter deficiency was established in female pigs by dilatation and cauterization, and amount and frequencies of voiding were monitored and explored by pad test. Sphincteric closure pressures were recorded prior to and immediately after treatment of each animal, and on day 21 by two techniques: standard urethral pressure profilometry (s-UPP) and high-definition urethral pressure profilometry (HD-UPP)...
September 22, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28938905/safe-sarpogrelate-anplone-in-femoro-popliteal-artery-intervention-efficacy-study-study-protocol-for-a-randomized-controlled-trial
#8
Sanghyun Ahn, Joongyub Lee, Seung-Kee Min, Jongwon Ha, Sang-Il Min, Song-Yi Kim, Min-Ji Cho, Sungsin Cho
BACKGROUND: Sarpogrelate is expected to reduce restenosis by protecting blood vessels from oxidative stress and vascular endothelial dysfunction as well as by acting as an antiplatelet agent after endovascular treatment (EVT). This trial was designed to compare aspirin plus sustained-release (SR) sarpogrelate with aspirin plus clopidogrel for the prevention of restenosis in patients with femoro-popliteal (FP) peripheral artery disease (PAD) who underwent EVT. METHODS/DESIGN: This is an open label, multicenter, prospective randomized controlled clinical trial...
September 22, 2017: Trials
https://www.readbyqxmd.com/read/28938901/validation-of-the-vascular-quality-of-life-questionnaire-6-for-clinical-use-in-patients-with-lower-limb-peripheral-arterial-disease
#9
Anne Sofie F Larsen, Anne Therese Reiersen, Morten B Jacobsen, Nils-Einar Kløw, Joakim Nordanstig, Mark Morgan, Jarlis Wesche
BACKGROUND: The VascuQoL-6 (VQ-6) health-related quality of life questionnaire, a short version of the disease-specific VascuQoL-25, was developed for clinical practice and use in vascular registries. The study purpose was to evaluate the validity and reliability of VQ-6. METHODS: VQ-6 was translated to Norwegian with linguistic validation and face value evaluation, and consecutive patients with intermittent claudication (IC) or critical limb ischemia (CLI) were included...
September 22, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28938784/immunocastration-as-an-alternative-to-caponization-evaluation-of-its-effect-on-body-and-bone-development-and-on-meat-color-and-composition
#10
M A G Quaresma, I C Antunes, M F Ribeiro, S Prazeres, R J B Bessa, P Martins da Costa
Caponization is associated with some morbidity and mortality, which contributes to important economic losses. This practice is executed without any pain relief (neither anesthesia nor analgesia) and can be painful and without consideration of animal welfare. On the other hand, immunocastration accomplished by Improvac and Bovipriva in pigs and cattle represents a noninvasive procedure, and for that reason is regarded as an alternative with improved animal welfare. This study includes 4 experimental groups consisting of capons, slips, roosters, and birds submitted to the Improvac treatment...
October 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/28938483/varying-susceptibility-of-the-female-mammary-gland-to-in-utero-windows-of-bpa-exposure
#11
Andrea R Hindman, Xiaokui Molly Mo, Hannah L Helber, Claire E Kovalchin, Nanditha Ravichandran, Alina R Murphy, Abigail M Fagan, Pamela M St John, Craig J Burd
In utero exposure to the endocrine disrupting compound bisphenol A (BPA) is known to disrupt mammary gland development and increase tumor susceptibility in rodents. It is unclear if there are different periods of in utero development that may be more susceptible to BPA exposure. Herein, pregnant CD-1 mice were exposed to BPA at different times during gestation that correspond to specific milestones of in utero mammary gland development. Mammary glands of early-life and adult female mice, exposed in utero to BPA, were morphologically and molecularly (ERα and Ki67) evaluated for developmental abnormalities...
August 9, 2017: Endocrinology
https://www.readbyqxmd.com/read/28938327/adipose-tissue-derived-stromal-vascular-fraction-increases-osteogenesis-in-an-experimental-design-zygomatic-bone-defect-model
#12
Gaye Toplu, Derya Ozcelik, Merdan Serin, Havva Erdem, Arzu Turkseven Topacoglu
INTRODUCTION: Facial bone defects are frequently encountered problems in clinical practice. Bone grafts, flaps, and alloplastic materials are often used in their treatment. This leads to donor site morbidity and prolongation of the operation. The authors have planned this study to examine whether adipose tissue derived stromal vascular fraction (SVF) has an osteogenic effect in the critical sized membranous bone defect of the zygomatic bone. MATERIALS AND METHODS: Twenty male Wistar Albino rats were used...
September 21, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28938322/the-relationship-of-the-temporal-branch-of-the-facial-nerve-to-the-fascial-planes-of-temporal-region-in-human-fetuses
#13
Özlem Elvan, Alev Bobuş Kara, Mesut Sabri Tezer, Mustafa Aktekin
The aim of this study was to obtain information by assessing the relationship between temporal region fascial structures, fat pads, and temporal branches of facial nerve in human fetuses to use the knowledge on treatment of early childhood period surgeries. This anatomic dissection study was conducted on 40 hemifaces with no visible external abnormalities on their faces. Fascial layers and related fat pads of temporal region were dissected layer by layer beginning from superficial to deep. The relations of temporal branches of facial nerve and temporoparietal fascia and the structures of these fascial layers were evaluated...
September 21, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28937414/rheumatoid-arthritis-and-citrullination
#14
Erika Darrah, Felipe Andrade
PURPOSE OF REVIEW: Dysregulated citrullination is a key element that drives the production and maintenance of antibodies to citrullinated proteins, a hallmark in rheumatoid arthritis (RA). This article reviews recent literature on the origin of citrullinated antigens in RA. RECENT FINDINGS: The study of synovial fluid from patients with RA has provided important insights into the identity of citrullinated proteins that accumulate in the RA joint (the RA citrullinome) and mechanisms that control their generation...
September 21, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28936788/isorhamnetin-derivatives-and-piscidic-acid-for-hypercholesterolemia-cholesterol-permeability-hmg-coa-reductase-inhibition-and-docking-studies
#15
Asma Ressaissi, Nebil Attia, Pedro Luis Falé, Rita Pacheco, Bruno L Victor, Miguel Machuqueiro, Maria Luísa M Serralheiro
Bioactive compounds, such as isorhamnetin and piscidic acid, were obtained from decoctions of cladodes (stem pads from Opuntia ficus-indica). The effect of these phenolic compounds, in a fiber-free extract, were evaluated as inhibitors of cholesterol permeation through a Caco-2 cell monolayer and as 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor. A reduction of 38% in cholesterol permeation through the Caco-2 cell monolayer was obtained, and the phenolic compounds all permeated between 6 and 9%. A mixture of these compounds showed an IC50 of 20...
September 21, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/28935419/red-near-infrared-light-stimulates-release-of-an-endothelium-dependent-vasodilator-and-rescues-vascular-dysfunction-in-a-diabetes-model
#16
Agnes Keszler, Brian Lindemer, Dorothee Weihrauch, Deron Jones, Neil Hogg, Nicole L Lohr
Peripheral artery disease (PAD) is a morbid condition whereby ischemic peripheral muscle causes pain and tissue breakdown. Interestingly, PAD risk factors, e.g. diabetes mellitus, cause endothelial dysfunction secondary to decreased nitric oxide (NO) levels, which could explain treatment failures. Previously, we demonstrated 670nm light (R/NIR) increased NO from nitrosyl-heme stores, therefore we hypothesized R/NIR can stimulate vasodilation in healthy and diabetic blood vessels. Vasodilation was tested by ex vivo pressure myography in wild type C57Bl/6, endothelial nitric oxide synthase (eNOS) knockout, and db/db mice (10mW/cm(2) for 5min with 10min dark period)...
September 18, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28933520/anticoagulation-and-antiplatelet-therapy-in-patients-with-peripheral-arterial-disease-of-the-femoro-popliteal-arteries
#17
Cornelis G Vos, Anco Vahl
Peripheral arterial disease (PAD) is associated with a substantial cardiovascular risk and secondary prevention is recommended for all patients. In this report the literature on anticoagulant and antiplatelet drugs for patients with PAD in the femoro-popliteal segment is reviewed. PubMED/MEDLINE and Cochrane Database was searched for studies published between January 1966 and August 2017. Meta-analyses and randomized controlled trials describing outcome of anticoagulants or antiplatelet drugs for secondary prevention or following vascular interventions in patients with PAD were included...
September 20, 2017: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/28933509/-targeting-the-skin-erythema-multiforme-in-dogs-and-cats
#18
Ralf Mueller, Teresa M S A Boehm, Christoph J Klinger, Laura Udraite, Ralf S Mueller
This review article will describe the complex nature of erythema multiforme in dogs and cats. The disease pattern will be illustrated in terms of etiology, pathogenesis, clinical signs, diagnostics and therapy. Erythema multiforme is a rare, immune-mediated skin disorder with an acute specific reaction pattern of skin and mucous membranes against different underlying causes. Reported triggering factors include drugs, food ingredients and neoplasias, but viral or bacterial infections and vaccine reactions were also identified...
September 20, 2017: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
https://www.readbyqxmd.com/read/28933232/reactive-oxygen-species-inhibit-catalytic-activity-of-peptidylarginine-deiminase
#19
Dres Damgaard, Mads Emil Bjørn, Peter Østrup Jensen, Claus Henrik Nielsen
Protein citrullination catalysed by peptidylarginine deiminase (PAD) may play an important pathogenic role in several chronic inflammatory diseases and malignancies. PAD2, PAD4, and citrullinated proteins are found in the synovium of rheumatoid arthritis patients. PAD activity is dependent on calcium and reducing conditions. However, reactive oxygen species (ROS) have been shown to induce citrullination of histones in granulocytes. Here we examine the ability of H2O2 and leukocyte-derived ROS to regulate PAD activity using citrullination of fibrinogen as read-out...
December 2017: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/28931998/trunk-function-in-hemiplegic-wheelchair-users-when-using-wheelchair-cushions
#20
Kyohei Kawada
[Purpose] The purpose of this study was to investigate adapting wheelchair cushions to hemiplegic individuals based on trunk function and a single-leg driving motion. [Subjects and Methods] Subjects were 18 hemiplegic adults who were able to use and sit up in a wheelchair. Subjects were grouped into Able and Unable groups according to the Functional Assessment for Control of the Trunk (FACT). The posterior pelvic tilt angle and the driving speed and muscle activity at the long head of the biceps femoris at the start of wheelchair use were measured for three wheelchair cushion conditions, and FACT factors and cushion factors were then analyzed...
September 2017: Journal of Physical Therapy Science
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