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https://www.readbyqxmd.com/read/29346401/cd1d-deficiency-inhibits-the-development-of-abdominal-aortic-aneurysms-in-ldl-receptor-deficient-mice
#1
Gijs H M van Puijvelde, Amanda C Foks, Rosemarie E van Bochove, Ilze Bot, Kim L L Habets, Saskia C de Jager, Mariëtte N D Ter Borg, Puck van Osch, Louis Boon, Mariska Vos, Vivian de Waard, Johan Kuiper
An abdominal aortic aneurysm (AAA) is a dilatation of the abdominal aorta leading to serious complications and mostly to death. AAA development is associated with an accumulation of inflammatory cells in the aorta including NKT cells. An important factor in promoting the recruitment of these inflammatory cells into tissues and thereby contributing to the development of AAA is angiotensin II (Ang II). We demonstrate that a deficiency in CD1d dependent NKT cells under hyperlipidemic conditions (LDLr-/-CD1d-/- mice) results in a strong decline in the severity of angiotensin II induced aneurysm formation when compared with LDLr-/- mice...
2018: PloS One
https://www.readbyqxmd.com/read/29344813/stroke-volume-variation-and-serum-creatinine-changes-during-abdominal-aortic-aneurysm-surgery-a-time-integrated-analysis
#2
Paolo Lentini, Luca Zanoli, Pasquale Fatuzzo, Faeq Husain-Syed, Rudi Stramanà, Diego Cognolato, Vincenzo Catena, Marco Baiocchi, Antonio Granata, Roberto Dell'Aquila
BACKGROUND: Patients undergoing abdominal aortic aneurysm (AAA) surgery with suprarenal clamping are at high risk for acute kidney injury (AKI) and major cardiac and cerebrovascular events (MACCE). We aimed to assess whether the stroke volume variation (SVV), a measure of hemodynamic instability, is associated with AKI in hypertensive patients undergoing elective AAA surgery with suprarenal clamping. METHODS: In a cohort of 51 hypertensive patients, we performed serial measurements of SVV (n = 459) and serum creatinine (sCr) (n = 255)...
January 17, 2018: Journal of Nephrology
https://www.readbyqxmd.com/read/29343666/the-c-terminal-extension-domain-of-saccharomyces-cerevisiae-mrpl32-a-homolog-of-ribosomal-protein-l32-functions-in-trans-to-support-mitochondrial-translation
#3
Ivo Ngundu Woogeng, Madoka Kitakawa
Mitochondrial ribosomal protein L32 (MrpL32) of Saccharomyces cerevisiae is homologous to the bacterial L32 ribosomal protein. MrpL32 carries an N-terminal mitochondrion-targeting sequence (MTS) and is about 60 amino acid residues longer at the C-terminus. Adding to its function as a leader sequence, the MTS of MrpL32 has been reported to regulate ribosome biogenesis through its processing by m-AAA protease. However, the function of the C-terminal extension (CE) remains totally unknown. Therefore, we constructed a series of C-terminally truncated mrpl32 (mrpl32ΔC) genes and expressed them in a Δmrpl32 mutant to examine their function...
January 17, 2018: Genes & Genetic Systems
https://www.readbyqxmd.com/read/29343179/b-type-natriuretic-peptide-for-prediction-of-incident-clinically-significant-abdominal-aortic-aneurysm-a-population-based-prospective-study
#4
Stefan Acosta, Anders Gottsäter, Gunnar Engström, Olle Melander, Moncef Zarrouk, Peter M Nilsson, J Gustav Smith
Pathogenesis of abdominal aortic aneurysm (AAA) is unclear. The aim of this study was to evaluate inflammatory and hemodynamic plasma biomarkers as predictors for AAA in the prospective longitudinal cohort of middle-aged individuals from the cardiovascular cohort of the Malmö Diet and Cancer Study ( n=5551; 1991-94). C-reactive protein, cystatin C, copeptin, N-terminal pro-B-type natriuretic peptide (N-BNP), midregional pro-atrial natriuretic peptide (MR-proANP) and conventional risk factors at baseline were measured in patients with incident AAA during follow-up and compared to individuals without a diagnosis of AAA...
January 1, 2018: Vascular Medicine
https://www.readbyqxmd.com/read/29342843/chiral-and-molecular-recognition-through-protonation-between-aromatic-amino-acids-and-tripeptides-probed-by-collision-activated-dissociation-in-the-gas-phase
#5
Akimasa Fujihara, Hikaru Inoue, Masanobu Sogi, Michiko Tajiri, Yoshinao Wada
Chiral and molecular recognition through protonation was investigated through the collision-activated dissociation (CAD) of protonated noncovalent complexes of aromatic amino acid enantiomers with l-alanine- and l-serine-containing tripeptides using a linear ion trap mass spectrometer. In the case of l-alanine-tripeptide (AAA), NH₃ loss was observed in the CAD of heterochiral H⁺(d-Trp)AAA, while H₂O loss was the main dissociation pathways for l-Trp, d-Phe, and l-Phe. The protonation site of heterochiral H⁺(d-Trp)AAA was the amino group of d-Trp, and the NH₃ loss occurred from H⁺(d-Trp)...
January 13, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29342417/a-study-of-the-cost-effectiveness-of-fenestrated-branched-evar-compared-with-open-surgery-for-patients-with-complex-aortic-aneurysms-at-2-years
#6
Morgane Michel, Jean-Pierre Becquemin, Jean Marzelle, Céline Quelen, Isabelle Durand-Zaleski
OBJECTIVES: The aim was to assess the cost-effectiveness of fenestrated and branched stent grafts (f/b EVAR) compared with open surgical repair (OSR) in thoraco-abdominal or complex abdominal aortic aneurysms (TAAA/AAA) at 2 years. METHODS: Two matched cohorts of patients with TAAA or complex AAA were compared after a follow-up of two years. Patients included in the WINDOW French multicentre prospective registry were treated by f/b EVAR, and OSR patients were extracted from the French national hospital discharge database...
January 13, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29341217/acetoacetate-and-ethyl-acetoacetate-as-novel-inhibitors-of-bacterial-biofilm
#7
S M Horne, M Schroeder, J Murphy, B M Prüβ
Acetoacetate (AAA) was identified as a biofilm inhibitor in a previous study, where the effect of 190 carbon and nitrogen sources on biofilm amounts by Escherichia coli O157:H7 was determined. With this study, we tested the effect of AAA on growth and biofilm amounts of Cronobacter sakazakii, Serratia marcescens, and Yersinia enterocolitica. AAA reduced growth and biofilm amounts of the three pathogens, albeit at rather high concentrations of 10 to 35 mg ml-1 . AAA at a concentration of 5 mg ml-1 reduced Y...
January 16, 2018: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/29340249/a-streptomycin-resistance-marker-in-h-%C3%A2-parasuis-based-on-site-directed-mutations-in-rpsl-gene-to-perform-unmarked-in-frame-mutations-and-to-verify-natural-transformation
#8
Ke Dai, Xintian Wen, Yung-Fu Chang, Sanjie Cao, Qin Zhao, Xiaobo Huang, Rui Wu, Yong Huang, Qigui Yan, Xinfeng Han, Xiaoping Ma, Yiping Wen
Haemophilus parasuis is a member of the family Pasteurellaceae and a major causative agent of Glässer's disease. This bacterium is normally a benign swine commensal but may become a deadly pathogen upon penetration into multiple tissues, contributing to severe lesions in swine. We have established a successive natural transformation-based markerless mutation system in this species. However, the two-step mutation system requires screening of natural competent cells, and cannot delete genes which regulate natural competence per se...
2018: PeerJ
https://www.readbyqxmd.com/read/29336260/adipocytes-and-abdominal-aortic-aneurysm-putative-potential-role-of-adipocytes-in-the-process-of-aaa-development
#9
Hirona Kugo, Tatsuya Moriyama, Nobuhiro Zaima
Background Adipose tissue plays a role in the storage of excess energy as triglycerides (TGs). Excess fat accumulation causes various metabolic and cardiovascular diseases. It has been reported that ectopic fat deposition and excess TG accumulation in non-adipose tissue might be important predictors of cardiometabolic and vascular risk. For example, ectopic fat in perivascular tissue promotes atherosclerotic plaque formation in the arterial wall. Objective Recently, it has been reported that ectopic fat (adipocyte) in the vascular wall of an abdominal aortic aneurysm (AAA) is present in both human and experimental animal models...
January 15, 2018: Current Drug Targets
https://www.readbyqxmd.com/read/29334914/-crying-without-tears-as-an-early-diagnostic-sign-post-of-triple-a-allgrove-syndrome-two-case-reports
#10
Daniel Tibussek, Sujal Ghosh, Angela Huebner, Joerg Schaper, Ertan Mayatepek, Katrin Koehler
BACKGROUND: Triple A syndrome (or Allgrove syndrome) is a rare autosomal recessive disorder characterized by alacrima, achalasia, adrenal insufficiency and autonomic/neurological abnormalities. The majority of cases are caused by mutations in the AAAS gene located on chromosome 12q13. However, the clinical picture as well as genetic testing may be complex since symptomatology is variable and mutations cannot be identified in all clinically diagnosed patients. We present two unrelated patients with triple-A syndrome illustrating the importance of alacrima as an early clinical sign...
January 15, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29334334/mortality-after-endovascular-treatment-of-infrarenal-abdominal-aortic-aneurysms-the-newer-the-better
#11
Aspasia Tzani, Ilias P Doulamis, Ioannis Katsaros, Eirini Martinou, Dimitrios Schizas, Konstantinos P Economopoulos
Although endovascular repair of infrarenal abdominal aortic aneurysms (EVAR) presents a delicate alternative treatment for abdominal aortic aneurysms (AAA) with lower perioperative mortality, its long-term efficacy remains a matter of concern. The purpose of this study was to evaluate the currently reported mortality evidence after EVAR and to examine the possible effect of aneurysm status and the study period on mortality rates. The PubMed and Cochrane bibliographical databases were thoroughly searched for studies reporting on more than 1 000 patients with non-ruptured or ruptured infrarenal AAA, treated with EVAR from August 1991 to September 2016...
January 15, 2018: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/29332924/multiple-recurrent-pseudoaneurysms-after-endovascular-repair-of-abdominal-aortic-aneurysm-in-a-patient-with-beh%C3%A3-et-s-disease
#12
Yohei Yamamoto, Yoshinori Inoue, Tsuyoshi Ichinose, Masato Nishizawa, Kimihiro Igari, Takahiro Toyofuku, Toshifumi Kudo
In Behçet's disease (BD) patients, endovascular repair is a reasonable alternative treatment for aortic aneurysms to avoid postoperative anastomotic pseudoaneurysms. However, there are some complications that may occur after endovascular repair. We herein report the case of a 40-year-old man with active BD developed recurrent aortic pseudoaneurysms at the proximal and distal margins of the stent graft and a femoral puncture site pseudoaneurysm 3 months after endovascular abdominal aortic aneurysm (AAA) repair...
January 15, 2018: Annals of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29328848/high-risk-endovascular-aneurysm-repair-a-case-report
#13
Samanthi De Silva
Mr AB is a 66-year old gentleman who presented for elective endovascular aneurysm repair (EVAR) following a routine screening scan identifying a 5.5cm abdominal aortic aneurysm (AAA). He had a past history of chronic obstructive pulmonary disease (COPD) with FEV1/FVC ratio of 48% on pre-assessment. He was hypertensive with a history of ischaemic heart disease (IHD), which has remained asymptomatic following coronary artery bypass grafting (CABG) eight years prior to this presentation.
October 2017: Journal of Perioperative Practice
https://www.readbyqxmd.com/read/29327587/conformational-impact-on-amino-acid-surface-%C3%AF-%C3%AF-interactions-on-a-7-7-single-walled-carbon-nanotube-a-molecular-mechanics-approach
#14
Linda Grabill, Andreas Riemann
A study of π-π interactions between a (7,7) single-walled carbon nanotube (SWNT) and three different aromatic amino acids (AAA), namely L-Tyrosine (Tyr), L-Tryptophan (Trp), and L-Phenylalanine (Phe) was conducted with a Molecular Mechanics (MM) approach. For each of the amino acids we investigated the behavior of six different conformers. We examined the impact of the so-called edge effects by testing the parameters of the built-in switching function in MM. We found the optimal SWNT length to be approximately 80Å for the size of the molecules in our conformational studies...
January 12, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29327574/review-on-management-and-outcomes-of-ruptured-abdominal-aortic-aneurysm-in-women
#15
Rita Soares Ferreira, Nelson Gomes Oliveira, José Oliveira-Pinto, Marie J van Rijn, Sander Ten Raa, Hence J Verhagen, Frederico Bastos Gonçalves
Vascular procedures in general, and specifically abdominal aortic aneurysm (AAA) repair, are associated with worse outcomes in female patients. However, how female gender influences outcomes in the setting of aneurysm-rupture remains unclear and may be even more pronounced when compared to elective operations. In this report, the authors aim to review the literature regarding ruptured AAA repair in women. Using the traditional threshold for AAA of 30mm of maximum diameter, the prevalence in women is lesser than in men...
January 9, 2018: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29327568/is-there-an-age-limit-for-abdominal-aortic-aneurysm-repair
#16
Björn Sonesson, Nuno Dias, Tim Resch
INTRODUCTION: There is an increasing number of elderly in society and some of them may have an abdominal aortic aneurysm (AAA). The prevalence of AAA in octo-and non-agenarians indicates that this number could be substantial. The question is; is there an age limit for repair? This complex question incorporates ethical, political, economic and medical aspects. To answer part of this question a review of the outcome of elective and emergent AAA repair in those over 80 was done. EVIDENCE ACQUSITION: A litterature research was done in the Pubmed and Embase databases between 2007 and 2017 for either emergent and/or elective repair of AAA in individuals older than 80 years of age...
January 9, 2018: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29327561/hostility-of-proximal-aortic-neck-anatomy-in-relation-to-abdominal-aortic-aneurysm-size-and-its-impact-on-the-outcome-of-endovascular-repair-with-the-new-generation-endografts
#17
Christos Karathanos, Konstantinos Spanos, George Kouvelos, Athanasios Athanasoulas, Stylianos Koutsias, Miltiadis Matsagkas, Athanasios D Giannoukas
BACKGROUND: To assess the relation of abdominal aortic aneurysm (AAA) diameter with the proximal neck anatomy (PNA) hostility and to evaluate its impact on the endovascular aneurysm repair (EVAR) outcomes with the use of newer generation endografts. METHODS: Retrospective analysis of single institution's recorded data from February 2009 to April 2016. Patients' characteristics, co-morbidities, aortic morphology, perioperative characteristics and outcomes were analyzed...
January 9, 2018: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29323271/cryo-em-structures-of-the-human-ino80-chromatin-remodeling-complex
#18
Ricardo J Aramayo, Oliver Willhoft, Rafael Ayala, Rohan Bythell-Douglas, Dale B Wigley, Xiaodong Zhang
Access to chromatin for processes such as transcription and DNA repair requires the sliding of nucleosomes along DNA. This process is aided by chromatin-remodeling complexes, such as the multisubunit INO80 chromatin-remodeling complex. Here we present cryo-EM structures of the active core complex of human INO80 at 9.6 Å, with portions at 4.1-Å resolution, and reconstructions of combinations of subunits. Together, these structures reveal the architecture of the INO80 complex, including Ino80 and actin-related proteins, which is assembled around a single RUVBL1 (Tip49a) and RUVBL2 (Tip49b) AAA+ heterohexamer...
January 2018: Nature Structural & Molecular Biology
https://www.readbyqxmd.com/read/29321502/the-peroxisomal-aaa-atpase-pex1-pex6-unfolds-substrates-by-processive-threading
#19
Brooke M Gardner, Dominic T Castanzo, Saikat Chowdhury, Goran Stjepanovic, Matthew S Stefely, James H Hurley, Gabriel C Lander, Andreas Martin
Pex1 and Pex6 form a heterohexameric motor essential for peroxisome biogenesis and function, and mutations in these AAA-ATPases cause most peroxisome-biogenesis disorders in humans. The tail-anchored protein Pex15 recruits Pex1/Pex6 to the peroxisomal membrane, where it performs an unknown function required for matrix-protein import. Here we determine that Pex1/Pex6 from S. cerevisiae is a protein translocase that unfolds Pex15 in a pore-loop-dependent and ATP-hydrolysis-dependent manner. Our structural studies of Pex15 in isolation and in complex with Pex1/Pex6 illustrate that Pex15 binds the N-terminal domains of Pex6, before its C-terminal disordered region engages with the pore loops of the motor, which then processively threads Pex15 through the central pore...
January 10, 2018: Nature Communications
https://www.readbyqxmd.com/read/29321388/suppression-of-abdominal-aortic-aneurysm-formation-in-mice-by-teneligliptin-a-dipeptidyl-peptidase-4-inhibitor
#20
Yusuke Takahara, Tomotake Tokunou, Toshihiro Ichiki
AIM: Dipeptidyl peptidase-4 (DPP-4) inhibitors lower blood glucose levels through inhibition of incretin degradation, which stimulates insulin secretion. Recent studies reported that DPP-4 inhibitors suppressed atherogenesis in apolipoprotein E-knockout (ApoEKO) mice. In this study, we investigated whether teneligliptin, a DPP-4 inhibitor, affects the development of abdominal aortic aneurysms (AAA) in ApoEKO mice. METHODS: ApoEKO mice were fed a high-fat diet (HFD) and infused with angiotensin (Ang) II by osmotic mini pumps for 4 weeks to induce AAA with (DPP-4i group) or without (control group) teneligliptin administered orally from 1 week before HFD and Ang II infusion to the end of the experiment...
January 10, 2018: Journal of Atherosclerosis and Thrombosis
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