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https://www.readbyqxmd.com/read/29230219/functional-impairment-of-mononuclear-phagocyte-system-by-the-human-respiratory-syncytial-virus
#1
REVIEW
Karen Bohmwald, Janyra A Espinoza, Raúl A Pulgar, Evelyn L Jara, Alexis M Kalergis
The mononuclear phagocyte system (MPS) comprises of monocytes, macrophages (MΦ), and dendritic cells (DCs). MPS is part of the first line of immune defense against a wide range of pathogens, including viruses, such as the human respiratory syncytial virus (hRSV). The hRSV is an enveloped virus that belongs to the Pneumoviridae family, Orthopneumovirus genus. This virus is the main etiological agent causing severe acute lower respiratory tract infection, especially in infants, children and the elderly. Human RSV can cause bronchiolitis and pneumonia and it has also been implicated in the development of recurrent wheezing and asthma...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29223630/postoperative-loss-of-midline-function-in-brachial-plexus-birth-palsy
#2
Dustin A Greenhill, Arianna Trionfo, Frederick V Ramsey, Scott H Kozin, Dan A Zlotolow
PURPOSE: To identify the rate of and predictive variables for functionally limited shoulder internal rotation in postoperative patients with brachial plexus birth palsy. METHODS: Records of patients with brachial plexus birth palsy who had surgery on the affected upper extremity during a 10-year period were retrospectively reviewed. Patient demographics, physical examinations, and all upper extremity procedures were recorded. Loss of midline function (LOM) was defined as a Modified Mallet Scale or Active Movement Scale (AMS) internal rotation score <3...
December 6, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29221036/direct-inscription-of-bragg-gratings-into-coated-fluoride-fibers-for-widely-tunable-and-robust-mid-infrared-lasers
#3
Gayathri Bharathan, Robert I Woodward, Martin Ams, Darren D Hudson, Stuart D Jackson, Alex Fuerbach
We report the development of a widely tunable all-fiber mid-infrared laser system based on a mechanically robust fiber Bragg grating (FBG) which was inscribed through the polymer coating of a Ho3+-Pr3+ co-doped double clad ZBLAN fluoride fiber by focusing femtosecond laser pulses into the core of the fiber without the use of a phase mask. By applying mechanical tension and compression to the FBG while pumping the fiber with an 1150 nm laser diode, a continuous wave (CW) all-fiber laser with a tuning range of 37 nm, centered at 2870 nm, was demonstrated with up to 0...
November 27, 2017: Optics Express
https://www.readbyqxmd.com/read/29217623/prostaglandins-d2-and-e2-have-opposite-effects-on-alveolar-macrophage-infected-with-histoplasma-capsulatum
#4
Priscilla A T Pereira, Patrícia A Assis, Morgana K B Prado, Simone Gusamão Ramos, David M Aronoff, Francisco W G Paula-Silva, Carlos A Sorgi, Lúcia H Faccioli
PGE2 suppresses macrophage effector mechanisms; however, little is known about the function of PGD2 in infected alveolar macrophages (AMs). Using serum opsonized Histoplasma capsulatum (ops-H. capsulatum) in vitro, we demonstrated that AMs produced PGE2 and PGD2 in a time-dependent manner, with PGE2 levels exceeding those of PGD2 by 48 h post-infection. Comparison of the effects of both exogenous PGs on AMs revealed that PGD2 increased phagocytosis and killing through the DP2 receptor, whereas PGE2 had opposite effects, through EP2/EP4-dependent mechanisms...
December 7, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/29214990/rna-sequencing-reveals-a-transcriptomic-portrait-of-human-mesenchymal-stem-cells-from-bone-marrow-adipose-tissue-and-palatine-tonsils
#5
Kyung-Ah Cho, Minhwa Park, Yu-Hee Kim, So-Youn Woo, Kyung-Ha Ryu
Human mesenchymal stem cells (MSCs) are adult multipotent cells that have plasticity and inhabit the stroma of diverse tissues. The potential utility of MSCs has been heavily investigated in the fields of regenerative medicine and cell therapy. However, MSCs represent diverse populations that may depend on the tissue of origin. Thus, the ability to identify specific MSC populations has remained difficult. Using RNA sequencing, we analyzed the whole transcriptomes of bone marrow-derived MSCs (BMs), adipose tissue-derived MSCs (AMs), and tonsil-derived MSCs (TMs)...
December 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29211407/long-term-results-of-the-implantation-of-the-ams-800-artificial-sphincter-for-post-prostatectomy-incontinence-a-single-center-experience
#6
Carlos Alberto Ricetto Sacomani, Stênio de Cássio Zequi, Walter Henriques da Costa, Bruno Santos Benigno, Rodrigo Sousa Madeira Campos, Wilson Bachega, Gustavo Cardoso Guimarães
OBJECTIVES: Report the long-term outcomes of the AMS 800 artificial sphincer (AS) for the treatment post-prostatectomy incontinence (PPI) in a single center in Brazil. MATERIALS AND METHODS: Clinical data from patients who underwent the procedure were retrieved from the medical records of individuals with more than 1 year of follow-up from May 2001 to January 2016. Continence status (number of pads that was used), complications (erosion or extrusion, urethral atrophy, and infection), malfunctions, and need for secondary implantation were evaluated...
December 7, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29208998/high-resolution-ams-dates-from-shubayqa-1-northeast-jordan-reveal-complex-origins-of-late-epipalaeolithic-natufian-in-the-levant
#7
Tobias Richter, Amaia Arranz-Otaegui, Lisa Yeomans, Elisabetta Boaretto
The Late Epipalaeolithic Natufian (~14,600 - 11,500 cal BP) is a key period in the prehistory of southwest Asia. Often described as a complex hunting and gathering society with increased sedentism, intensive plant exploitation and associated with an increase in artistic and symbolic material culture, it is positioned between the earlier Upper- and Epi-Palaeolithic and the early Neolithic, when plant cultivation and subsequently animal domestication began. The Natufian has thus often been seen as a necessary pre-adaptation for the emergence of Neolithic economies in southwest Asia...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29204852/european-antibiotic-awareness-day-2017-training-the-next-generation-of-health-care-professionals-in-antibiotic-stewardship
#8
Lenneke Schrier, Adamos Hadjipanayis, Stefano Del Torso, Tom Stiris, Marieke Emonts, Hans Juergen Dornbusch
Antimicrobial stewardship (AMS) aims to optimise treatment, minimise the risk of adverse effects and reduce health care costs. In addition, it is recognised as a key component to stop the current spread of antimicrobial resistance in Europe. Educational programmes are particularly important for the successful implementation of AMS. Training should start during medical school, continue during clinical training and be reinforced throughout postgraduate training. National core curricula for paediatric training should include passive and active training of competencies needed for AMS and future paediatricians should be skilled in taking leadership roles in AMS initiatives...
December 5, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29203844/complications-functional-and-quality-of-life-outcomes-following-primary-and-secondary-implantation-of-penile-prosthesis-at-a-tertiary-referral-center
#9
Bernhard Ralla, Irena Goranova, Niels Börnstein, Frank Friedersdorff, Andreas Maxeiner, Ahmed Magheli, Stefan Hinz, Joerg Neymeyer, Kurt Miller, Jonas Busch
The implantation of a penile prosthesis (PP) may be recommended in patients with severe erectile dysfunction (ED) who do not respond to conservative treatments. The aim of this study was to evaluate complications, as well as functional and quality of life outcomes following primary and secondary implantation of PP at a tertiary referral center. In this retrospective study, a total of 51 patients (41 patients with primary (PPP) and 10 with secondary PP (SPP)) were included. Patients and operative characteristics were recorded and complications were analyzed using the Clavien-Dindo classification...
December 4, 2017: International Journal of Impotence Research
https://www.readbyqxmd.com/read/29202868/sp-a2-contributes-to-mirna-mediated-sex-differences-in-response-to-oxidative-stress-pro-inflammatory-anti-apoptotic-and-anti-oxidant-pathways-are-involved
#10
George T Noutsios, Nithyananda Thorenoor, Xuesheng Zhang, David S Phelps, Todd M Umstead, Faryal Durrani, Joanna Floros
BACKGROUND: Human innate host defense molecules, surfactant protein A1 (SP-A1), and SP-A2 differentially affect the function and proteome of the alveolar macrophage (AM). We hypothesized that SP-A genes differentially regulate the AM miRNome. METHODS: Humanized transgenic mice expressing SP-A1 and SP-A2 were subjected to O3-induced oxidative stress (OxS) or filtered air (FA), AMs were isolated, and miRNA levels were measured. RESULTS: In SP-A2 males, we found significant changes in miRNome in terms of sex and sex-OxS effects, with 11 miRNAs differentially expressed under OxS...
December 4, 2017: Biology of Sex Differences
https://www.readbyqxmd.com/read/29201532/clinical-presentation-epidemiology-neurophysiological-findings-treatment-and-outcome-of-nonconvulsive-status-epilepticus-a-3-year-prospective-hospital-based-study
#11
Boulenouar Mesraoua, Dirk Deleu, Hassan Al Hail, Faisal Ibrahim, Gayane Melikyan, Hassan Al Hussein, Rajvir Singh, Basim Uthman, Leopold Streletz, Peter W Kaplan, Heinz Gregor Wieser
Objective: This study reports the prevalence of Nonconvulsive Status Epilepticus (NCSE) in patients with altered mental status (AMS), and describes the clinical presentation, etiology, neurophysiological findings, neuroimaging, treatment, and outcome of NCSE in Qatar. Recording duration of continuous EEG monitoring was also discussed. Methods: This was a 3-year, prospective, hospital-based study involving patients with AMS and continuous EEG monitoring admitted to the Emergency and ICUs of Hamad Hospital, Qatar...
2017: Journal of Drug Assessment
https://www.readbyqxmd.com/read/29193885/aquammaps-an-alternative-tool-to-monitor-the-role-of-water-molecules-during-protein-ligand-association
#12
Alberto Cuzzolin, Giuseppe Deganutti, Veronica Salmaso, Mattia Sturlese, Stefano Moro
Unquestionably water appears to be an active player in noncovalent protein-ligand association processes, as it can either bridge interactions between protein and ligand or can be replaced by the bound ligand. Accordingly, in the last decade, alternative computational methodologies have been sought, that guess the position and thermodynamic profile of water molecules (i.e., hydration sites) in the binding site using either the ligand-bound or ligand-free protein conformation. Herein, we present an alternative approach, named AquaMMapS, that provides a three-dimensional sampling of putative hydration sites...
November 29, 2017: ChemMedChem
https://www.readbyqxmd.com/read/29172727/objective-versus-self-reported-sleep-quality-at-high-altitude
#13
Paul J Anderson, Christina M Wood-Wentz, Kent R Bailey, Bruce D Johnson
Anderson, Paul J., Christina M. Wood-Wentz, Kent R. Bailey, and Bruce D. Johnson. Objective versus self-reported sleep quality at high altitude. High Alt Med Biol. 16:000-000, 2017. BACKGROUND: Previous studies have found little relationship between polysomnography and a diagnosis of acute mountain sickness (AMS) using the Lake Louise Symptom Questionnaire (LLSQ). The correlation between sleep question responses on the LLSQ and polysomnography results has not been explored. We compared LLSQ sleep responses and polysomnography data from our previous study of workers rapidly transported to the South Pole...
November 27, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/29166795/pharmacological-interventions-for-preventing-acute-mountain-sickness-a-network-meta-analysis-and-trial-sequential-analysis-of-randomized-clinical-trials
#14
Kannan Sridharan, Gowri Sivaramakrishnan
BACKGROUND: Individuals ascending to high altitude are at a risk of getting acute mountain sickness (AMS). The present study is a network meta-analysis comparing all the interventions available to prevent AMS. METHODS: Electronic databases were searched for randomized clinical trials evaluating the use of drugs to prevent AMS. Incidence of AMS was the primary outcome and incidence of severe AMS, paraesthesia (as side effect of acetazolamide use), headache and severe headache, and oxygen saturation were the secondary outcomes...
November 23, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/29166384/neanderthal-hunting-strategies-inferred-from-mortality-profiles-within-the-abric-roman%C3%A3-sequence
#15
Juan Marín, Palmira Saladié, Antonio Rodríguez-Hidalgo, Eudald Carbonell
Ungulate mortality profiles are commonly used to study Neanderthal subsistence strategies. To assess the hunting strategies used by Neanderthals, we studied the ages at death of the cervids and equids found in levels E, H, I, Ja, Jb, K, L and M of the Abric Romaní sequence. These levels date between 43.2 ± 1.1 ka BP (14C AMS) and 54.5 ± 1.7 ka BP (U-series). The degree of eruption and development of the teeth and their wear stages were used to determine the ages of these animals at death, and mortality profiles were constructed using these data...
2017: PloS One
https://www.readbyqxmd.com/read/29157088/examining-the-effect-of-the-computer-based-educational-package-on-quality-of-life-and-severity-of-hypogonadism-symptoms-in-males
#16
Elahe Afsharnia, Minoo Pakgohar, Shahla Khosravi, Hamid Haghani
OBJECTIVE: The objective of this study was to determine the effect of the computer-based educational package on men's QoL and the severity of their hypogonadism symptoms. METHODS: A quasi-experimental study was conducted on 80 male employees. The data collection tool included the 'Aging Male Symptoms' (AMS) and 'Short Form-36' (SF36) questionnaires. Four sessions were held for the intervention group over a period of 4 weeks. Two months after training, QoL and the severity of hypogonadism symptoms were measured in both the intervention and control groups...
November 20, 2017: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/29154653/symbolic-number-skills-predict-growth-in-nonsymbolic-number-skills-in-kindergarteners
#17
Ian M Lyons, Stephanie Bugden, Samuel Zheng, Stefanie De Jesus, Daniel Ansari
There is currently considerable discussion about the relative influences of evolutionary and cultural factors in the development of early numerical skills. In particular, there has been substantial debate and study of the relationship between approximate, nonverbal (approximate magnitude system [AMS]) and exact, symbolic (symbolic number system [SNS]) representations of number. Here we examined several hypotheses concerning whether, in the earliest stages of formal education, AMS abilities predict growth in SNS abilities, or the other way around...
November 20, 2017: Developmental Psychology
https://www.readbyqxmd.com/read/29153259/reduction-of-olfactory-sensitivity-during-normobaric-hypoxia
#18
Tilman Huppertz, Jessica Freiherr, Bernhard Olzowy, Ulrich Kisser, Jutta Stephan, Gunther Fesl, Kathrin Haegler, Berend Feddersen, Rainald Fischer, Klaus Mees, Sven Becker
OBJECTIVE: Acute mountain sickness (AMS) is caused by a low partial pressure of oxygen and may occur above 2500m. The aim of this research was to evaluate olfactory and gustatory abilities of healthy subjects during baseline conditions and after seven hours of normobaric hypoxia. METHODS: Sixteen healthy subjects were assessed using the Sniffin' Sticks, as well as intensity and pleasantness ratings. Gustatory function was evaluated utilizing the Taste Strips. Experiments were carried out under baseline conditions (518m altitude) followed by a second testing session after seven hours of normobaric hypoxia exposure (comparable to 4000m altitude)...
November 15, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29150510/characterization-of-vibrio-parahaemolyticus-and-vibrio-vulnificus-recovered-from-oysters-during-an-oyster-relay-study
#19
Sara Elmahdi, Salina Parveen, Sylvia Ossai, Ligia V DaSilva, Michael Jahncke, John Bowers, John Jacobs
Vibrio parahaemolyticus (Vp) and Vibrio vulnificus (Vv) are naturally occurring estuarine bacteria and are the leading causes of seafood-associated infections and mortality in the USA. Though multiple-antibiotic resistant Vp and Vv have been reported resistance patterns in vibrios are not as well documented as other food-borne bacterial pathogens. Salinity relaying (SR) is a Post-Harvest Processing (PHP) treatment to reduce the abundance of these pathogens in shellfish harvested during the warmer months. The purpose of this study was to evaluate the antimicrobial susceptibility (AMS), pathogenicity and genetic profiles of Vp and Vv recovered from oysters during an oyster relay study...
November 17, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29144759/degree-of-unsaturation-and-backbone-orientation-of-amphiphilic-macromolecules-influence-local-lipid-properties-in-large-unilamellar-vesicles
#20
Kathryn E Uhrich, Alysha Moretti, Bin Zhang, Bernice Lee, Meenakshi Dutt
Liposomes have become increasingly common in the delivery of bioactive agents due to their ability to encapsulate hydrophobic and hydrophilic drugs with excellent biocompatibility. While commercial liposome formulations improve bioavailability of otherwise quickly eliminated or insoluble drugs, tailoring formulation properties for specific uses has become a focus of liposome research. Here, we report the design, synthesis, and characterization of two series of amphiphilic macromolecules (AMs), consisting of acylated polyol backbones conjugated to poly(ethylene glycol) (PEG) that can serve as the sole additives to stabilize and control hydrophilic molecule release rates from distearoyl-phosphatidylcholine- (DSPC-) based liposomes...
November 16, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
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