Read by QxMD icon Read


Eiad AlFaris, Farhana Irfan, Riaz Qureshi, Naghma Naeem, Abdulaziz Alshomrani, Gominda Ponnamperuma, Nada Al Yousufi, Nasr Al Maflehi, Mohammad Al Naami, Amr Jamal, Cees van der Vleuten
BACKGROUND: There is a need to better understand the depression phenomenon and to clarify why some students become depressed and others don't. The purpose of this study was to compare the prevalence of depressive symptoms among health professions' (HP) students, and to explore the association between socio-demographic factors (e.g. year of study, discipline, gender) and depressive symptoms. METHODS: In this descriptive-analytic, cross-sectional study, stratified proportionate sampling strategy was used to select the study sample during the academic year 2012-2013...
October 21, 2016: BMC Medical Education
Mehmet Ali Aslaner, Mustafa Boz, Ali Çelik, Asliddin Ahmedali, Sercan Eroğlu, Nalan Metin Aksu, Serkan Emre Eroğlu
OBJECTIVES: Altered mental status (AMS) is a challenging diagnosis in older patients and has a large range of etiologies. The aim of this study was to investigate the nature of such etiologies for physicians to be better aware of AMS backgrounds and hence improve outcomes and mortality rates. METHODS: This prospective observational study was conducted at 4 emergency departments. Patients 65 years and older who presented to the emergency department with acute AMS (≤1 week), with symptoms ranging from comas and combativeness, were eligible for inclusion in this study...
October 5, 2016: American Journal of Emergency Medicine
B Li, J Liu, Y Y Zhang, P Q Wang, Y N Yu, R X Kang, H L Wu, X X Zhang, Z Wang, Y Y Wang
Module-based methods have made much progress in deconstructing biological networks. However, it is a great challenge to quantitatively compare the topological structural variations of modules (allosteric modules [AMs]) under different situations. A total of 23, 42, and 15 coexpression modules were identified in baicalin (BA), jasminoidin (JA), and ursodeoxycholic acid (UA) in a global anti-ischemic mice network, respectively. Then, we integrated the methods of module-based consensus ratio (MCR) and modified Zsummary module statistic to validate 12 BA, 22 JA, and 8 UA on-modules based on comparing with vehicle...
October 19, 2016: CPT: Pharmacometrics & Systems Pharmacology
A D Wibawa, N Verdonschot, J P K Halbertsma, J G M Burgerhof, R L Diercks, G J Verkerke
This study focused on comparing muscle activities predicted by the Musculoskeletal Modeling System with EMG from ten healthy subjects who performed normal walking, one-legged forward hopping and side jumping. Eight EMG electrodes measured the activity of eight right leg muscles. Specific thresholds per muscle were applied on the EMG prior comparison. These thresholds were determined by equalizing the duration of EMG to AMS muscle activity. Three graph variables, number of onsets, offsets and hills were used to quantify the level of agreement by using Cohen׳s kappa analysis...
October 6, 2016: Journal of Biomechanics
Evelyn K Ansah, Christopher Jm Whitty, Constance Bart-Plange, Margaret Gyapong
BACKGROUND: Most people with febrile illness are treated in the private drug retail sector. Ghana was among nine countries piloting the Global Fund Affordable Medicines Facility - malaria (AMFm). AMFm aimed to: increase artemisinin combination therapy (ACT) affordability; increase ACT availability; increase ACT use; and 'crowd out' artemisinin monotherapies. METHODS: Three censuses were carried out 2 months before (2010), 2 months after and 2.5 years after (2013) the first co-paid ACTs to assess changes in antimalarial (AM) availability and price in private retail shops in a Ghanaian rural district to assess the sustainability of the initial gains...
October 15, 2016: International Health
S D Stites, C A Cooblall, J Aronovitz, S B Singletary, K Micklow, M Sjeime
BACKGROUND: The incidence and severity of Clostridium difficile infection (CDI) have increased in recent years. Predictive models may help to identify at-risk patients before the onset of infection. Early identification of high-risk patients could help antimicrobial stewardship (AMS) programmes and other initiatives to better prevent C. difficile in these patients. AIM: To develop a predictive model that identifies patients at high risk for CDI at the time of hospitalization...
August 24, 2016: Journal of Hospital Infection
Taylor S Cohen, Omari Jones-Nelson, Meghan Hotz, Lily Cheng, Lloyd S Miller, JoAnn Suzich, C Kendall Stover, Bret R Sellman
Bacterial pneumonia, such as those caused by Staphylococcus aureus, is associated with an influx of inflammatory neutrophils into the lung tissue and airways. Regulation and clearance of recruited neutrophils is essential for preventing tissue damage by "friendly fire", a responsibility of macrophages in a process called efferocytosis. We hypothesized that S. aureus impairs efferocytosis by alveolar macrophages (AMs) through the activity of the secreted virulence factor alpha toxin (AT), which has been implicated in altering the antimicrobial function of AMs...
October 14, 2016: Scientific Reports
Hadi Fayad, Holger Schmidt, Thomas Kuestner, Dimitris Visvikis
: Respiratory motion may reduce accuracy in fusion of functional and anatomical images using combined Positron emission tomography / Magnetic resonance (PET/MR) systems. Methodologies for the correction of respiratory motion in PET acquisitions using such systems are mostly based on the use of respiratory synchronized MR acquisitions to derive motion fields. Existing approaches based on tagging acquisitions may introduce artifacts in the MR images, while motion model approaches require the acquisition of training datasets...
October 13, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Klaus Gjervig Jensen, Anne-Marie Jacobsen, Christoffer Bundgaard, Dorrit Ostergaard Nilausen, Zia Thale, Gamini Chandrasena, Martin Jorgensen
Inclusion of a microdose of (14)C-labeled drug in the first-in-man study of new investigational drugs and subsequent analysis by accelerator mass spectrometry has become an integrated part of drug development at Lundbeck. It has been found to be highly informative with regards to investigations of the routes and rates of excretion of the drug and the human metabolite profiles according to MIST guidance, and also when additional metabolism related issues needed to be addressed. In the first-in-man study with the NCE Lu AF09535, contrary to anticipated, surprisingly low exposure was observed when measuring the parent compound using conventional bioanalysis...
October 13, 2016: Drug Metabolism and Disposition: the Biological Fate of Chemicals
Satyavrata Samavedi, Patricia Diaz-Rodriguez, Joshua Dean Erndt-Marino, Mariah Hahn
The goal of the present study was to develop a fully 3D co-culture system that would allow for systematic investigation of the interplay between activated macrophages and chondrocytes in osteoarthritic disease progression. Toward this end, our 3D co-culture system was first validated against existing in vitro osteoarthritis models, which have generally cultured healthy normal chondrocytes (NCs) ─ in 2D or 3D ─ with 2D classically activated macrophages (AMs). In the current work, NCs and AMs were both encapsulated within poly(ethylene glycol) diacrylate hydrogels to better mimic the native 3D environments of both cell types within the osteoarthritic joint...
October 13, 2016: Tissue Engineering. Part A
Yu-Mei Wu, Zhi-Wei Wang, Chang-Ying Hu, Cristina Nerín
Antimicrobial packaging materials (films or coatings) (APMs) have aroused great interest among the scientists or the experts specialized in material science, food science, packaging engineering, biology and chemistry. APMs have been used to package the food such as dairy products, poultry, meat (e.g. beef), salmon muscle, pastry dough, fresh pasta, bakery products, fruits, vegetables and beverages. Some materials have been already commercialized. The ability of APMs to extend the shelf-life of the food depends on the release rate of the antimicrobials (AMs) from the materials to the food...
October 13, 2016: Critical Reviews in Food Science and Nutrition
Victor Kuete, Joachim K Dzotam, Igor K Voukeng, Aimé G Fankam, Thomas Efferth
BACKGROUND: Cancer cells rapidly acquire resistance leading to treatment failures. In the present study, we have evaluated the cytotoxicity of 17 methanol extracts from 11 Cameroonian medicinal plants against the sensitive leukemia CCRF-CEM cells and the best ones were further tested on a panel of 8 other human cancer cell lines, including various MDR phenotypes as well as against the normal AML12 hepatocytes. METHODS: The cytotoxicity of the extracts was determined using a resazurin reduction assay meanwhile flow cytometry was used to measure cell cycle, apoptosis, mitochondrial membrane potential (MMP), and reactive oxygen species...
2016: SpringerPlus
Heather A Enright, Michael A Malfatti, Maike Zimmermann, Ted Ognibene, Paul Henderson, Kenneth W Turteltaub
Accelerator mass spectrometry (AMS) has been adopted as a powerful bioanalytical method for human studies in the areas of pharmacology and toxicology. The exquisite sensitivity (10(-18) mol) of AMS has facilitated studies of toxins and drugs at environmentally and physiologically relevant concentrations in humans. Such studies include risk assessment of environmental toxicants, drug candidate selection, absolute bioavailability determination, and more recently, assessment of drug-target binding as a biomarker of response to chemotherapy...
October 11, 2016: Chemical Research in Toxicology
Alexandar L Hansen, Rafael Brüschweiler
Standard three-dimensional Fourier transform (FT) NMR experiments of molecular systems often involve prolonged measurement times due to extensive sampling required along the indirect time domains to obtain adequate spectral resolution. In recent years, a wealth of alternative sampling methods has been proposed to ease this bottleneck. However, due to their algorithmic complexity, for a given sample and experiment it is often hard to determine the minimal sampling requirement, and hence the maximal achievable experimental speed up...
October 10, 2016: Angewandte Chemie
Anika Frühauf, Martin Burtscher, Elena Pocecco, Martin Faulhaber, Martin Kopp
PURPOSE: There is an ongoing discussion how to assess acute mountain sickness (AMS) in real life conditions. Next to more-item scales with a cut off like the Lake Louise Self-Report (LLS), some authors suggested to use visual analog scales (VAS) to assess AMS. This study tried to contribute to this question using VAS items used for the Subjective Ratings of Drug Effects, including an additional single item for AMS. Furthermore, we investigated if instruments developed to assess psychological well-being might predict AMS assessed via LLS or VAS...
2016: SpringerPlus
Peter Løvendahl, Lars Peter Sørensen, Martin Bjerring, Jan Lassen
Dairy cows milked in automatic milking systems (AMS) with more than 1 milking box may, as individuals, have a preference for specific milking boxes if allowed free choice. Estimates of quantitative genetic variation in behavioral traits of farmed animals have previously been reported, with estimates of heritability ranging widely. However, for the consistency of choice in dairy cows, almost no published estimates of heritability exist. The hypothesis for this study was that choice consistency is partly under additive genetic control and partly controlled by permanent environmental (animal) effects...
October 5, 2016: Journal of Dairy Science
Zhangshun Liu, Jie Liu, Xiaohong Shi, Lihong Wang, Yan Yang, Minfang Tao, Qiang Fu
OBJECTIVE: The aim of this study is to compare calculated free testosterone (cFT) and total testosterone (T) in predicting late-onset hypogonadism (LOH) in middle-aged and elderly males. METHODS: We surveyed a random sample of 608 males between the ages of 45 and 87 years from Shanghai, China. The Aging Male Symptoms (AMS) questionnaire and the Androgen Deficiency in Aging Male (ADAM) questionnaire were completed by the subjects. Testosterone (T), sex hormone-binding globulin (SHBG), albumin, and other blood biochemical indexes were measured in 332 males...
October 7, 2016: Journal of Clinical Laboratory Analysis
Bharath Kumar, Abhishek Chakraborty, S N Tripathi, Deepika Bhattu
Non-refractory submicron (NR-PM1) aerosols were measured during the late winter period (February-March) via an Aerodyne High Resolution Time of Flight Aerosols Mass Spectrometer (HR-ToF-AMS) along with Black Carbon (BC) and trace gasses in an industrial city, Kanpur, situated in the Gangetic Plain (GP) of India. The composition of NR-PM1 aerosols was dominated by organics (54%), followed by inorganics (36%), and BC (10%). Source apportionment via Positive Matrix Factorization (PMF) of AMS measured organic aerosols (OAs) revealed 6 factors...
October 12, 2016: Environmental Science. Processes & Impacts
Alexander L Vogel, Johannes Schneider, Christina Müller-Tautges, Gavin J Phillips, Mira L Pöhlker, Diana Rose, Christoph Zuth, Ulla Makkonen, Hannele Hakola, John N Crowley, Meinrat O Andreae, Ulrich Pöschl, Thorsten Hoffmann
Aerosol hygroscopic properties were linked to its chemical composition by using complementary online mass spectrometric techniques in a comprehensive chemical characterization study at a rural mountaintop station in central Germany in August 2012. In particular, atmospheric pressure chemical ionization mass spectrometry ((-)APCI-MS) provided measurements of organic acids, organosulfates, and nitrooxy-organosulfates in the particle phase at 1 min time resolution. Offline analysis of filter samples enabled us to determine the molecular composition of signals appearing in the online (-)APCI-MS spectra...
October 6, 2016: Environmental Science & Technology
Shuting Xu, Yiding Zhang, Linnan Xu, Yu Bai, Huwei Liu
Since ambient mass spectrometry (AMS) has been proven to have low matrix effects and high salt tolerance, great efforts have been made for online coupling of several analytical techniques with AMS. These analytical techniques include gas chromatography (GC), liquid chromatography (LC), capillary electrophoresis (CE), surface plasmon resonance (SPR), and electrochemistry flow cells. Various ambient ionization sources, represented by desorption electrospray ionization (DESI) and direct analysis in real time (DART), have been utilized as interfaces for the online coupling techniques...
October 17, 2016: Analyst
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"