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Thomas Schneider, Dietmar Ikemeyer, Ole MÜller, Henri J Dumont
Iran has a complex dragonfly fauna influenced by contacts and overlaps of different geographical zones. Its fauna is dominated by Eurosiberian taxa. However, the SE Province Sistãn-va-Baluchestãn is rich in oriental species, many of which having their western distribution limit in Iran. In NE-Iran, Irano-Turanian elements live and in the S- and SW-Iran African species are found. The Iranian Odonata fauna seems well studied, however, a closer look reveals many uncertainties and confusion, some records coming clearly from misidentification whereas other, which were missing proofs of correct identification remains to be confirmed...
March 12, 2018: Zootaxa
Joel Corbin, Amewu Antoinette Mensah, Simone Maria Pieber, Jürgen Orasche, Bernhard Michalke, Marco Zanatta, Hendryk Czech, Dario Massabò, Francesco Buatier de Mongeot, Carlo Mennucci, Imad El Haddad, Nivedita K Kumar, Benjamin Stengel, Yuting Huang, Ralf Zimmermann, Andre S H Prevot, Martin Gysel
Heavy fuel oil (HFO) particulate matter (PM) emitted by marine engines is known to contain toxic heavy metals including vanadium (V) and nickel (Ni). The toxicity of such metals will depend on the their chemical state, size distribution, and mixing state. Using online soot-particle aerosol mass spectrometry (SP-AMS), we quantified the mass of five metals (V, Ni, Fe, Na, and Ba) in HFO-PM soot particles produced by a marine diesel research engine. The in-soot metal concentrations were compared to 25 in-PM 2...
April 24, 2018: Environmental Science & Technology
Rangabhashiyam Selvasembian, Balasubramanian P
Biosorption potential of novel lignocellulosic biosorbents Musa sp. peel (MSP) and Aegle marmelos shell (AMS) was investigated for the removal of toxic triphenylmethane dye malachite green (MG), from aqueous solution. Batch experiments were performed to study the biosorption characteristics of malachite green onto lignocellulosic biosorbents as a function of initial solution pH, initial malachite green concentration, biosorbents dosage, and temperature. Biosorption equilibrium data were fitted to two and three parameters isotherm models...
May 12, 2018: International Journal of Phytoremediation
J H Rowland, S P Harteis, L Yuan
In 1995 and 2003, the U.S. Mine Safety and Health Administration (MSHA) conducted surveys to determine the number of atmospheric monitoring systems (AMS) that were being used in underground coal mines in the United States. The survey reports gave data for the different AMS manufacturers, the different types of equipment monitored, and the different types of gas sensors and their locations. Since the last survey in 2003, MSHA has changed the regulation requirements for early fire detection along belt haulage entries...
February 2018: Mining Engineering
Surendra Dawadi, Helena I M Boshoff, Sae Woong Park, Dirk Schnappinger, Courtney C Aldrich
5'- O -[ N -(Salicyl)sulfamoyl]adenosine (Sal-AMS, 1 ) is a nucleoside antibiotic that inhibits incorporation of salicylate into siderophores required for bacterial iron acquisition and has potent activity against Mycobacterium tuberculosis ( Mtb ). Cinnolone analogues exemplified by 5 were designed to replace the acidic acyl-sulfamate functional group of 1 (p K a = 3) by a more stable sulfonamide linkage (p K a = 6.0) in an attempt to address potential metabolic liabilities and improve membrane permeability...
April 12, 2018: ACS Medicinal Chemistry Letters
Matthew R Bockman, Curtis A Engelhart, Surendra Dawadi, Peter Larson, Divya Tiwari, David M Ferguson, Dirk Schnappinger, Courtney C Aldrich
5'-[ N-(d-biotinoyl)sulfamoyl]amino-5'-deoxyadenosine (Bio-AMS, 1) possesses selective activity against Mycobacterium tuberculosis ( Mtb) and arrests fatty acid and lipid biosynthesis through inhibition of the Mycobacterium tuberculosis biotin protein ligase ( MtBPL). Mtb develops spontaneous resistance to 1 with a frequency of at least 1 × 10-7 by overexpression of Rv3406, a type II sulfatase that enzymatically inactivates 1. In an effort to circumvent this resistance mechanism, we describe herein strategic modification of the nucleoside at the 5'-position to prevent enzymatic inactivation...
April 17, 2018: ACS Infectious Diseases
Liyuan Sun, Liangjing Chen, Lina Bai, Yongpeng Xia, Xiaobo Yang, Wei Jiang, Wenjun Sun
PURPOSE: Exposure to extremely low frequency electromagnetic fields (ELF-MFs) could elicit biological effects including carcinogenesis. However, the detailed mechanisms by which these ELF-MFs interact with biological system are currently unclear. Previously, we found that a 50-Hz magnetic field (MF) exposure could induce epidermal growth factor receptor (EGFR) clustering and phosphorylation on cell membranes. In the present experiment, the possible roles of reactive oxygen species (ROS) in MF-induced EGFR clustering were investigated...
April 16, 2018: International Journal of Radiation Biology
Christine Happle, Nico Lachmann, Mania Ackermann, Anja Mirenska, Gudrun Göhring, Kathrin Thomay, Adele Mucci, Miriam Hetzel, Torsten Glomb, Takuji Suzuki, Claudia Chalk, Silke Glage, Oliver Dittrich-Breiholz, Bruce Trapnell, Thomas Moritz, Gesine Hansen
Rationale While the transplantation of induced pluripotent stem cell (iPSC)-derived cells harbors enormous potential for the treatment of pulmonary diseases, in vivo data demonstrating clear therapeutic benefits of human iPSC-derived cells in lung disease models is missing. Objective We here tested the therapeutic potential of iPSC-derived macrophages in a humanized disease model of hereditary pulmonary alveolar proteinosis (herPAP). herPAP is caused by a genetic defect of the GM-CSF-receptor, which leads to disturbed macrophage differentiation and protein/surfactant degradation in the lungs subsequently resulting in severe respiratory insufficiency...
April 13, 2018: American Journal of Respiratory and Critical Care Medicine
Sharon J Gardiner, Sarah Cl Metcalf, Paul Kl Chin, Matthew P Doogue, Simon C Dalton, Stephen T Chambers
AIMS: To evaluate an antimicrobial stewardship (AMS) initiative to change hospital prescribing practice for metronidazole. METHODS: In October 2015, the Canterbury District Health Board (CDHB) AMS committee changed advice for metronidazole to promote two times daily dosing for most indications, prioritisation of the oral route and avoidance of double anaerobic cover. Adoption of the initiative was facilitated via change in prescribing guidelines, education and ongoing pharmacy support...
April 13, 2018: New Zealand Medical Journal
Antonino De Lorenzo, Annalisa Noce, Eleonora Moriconi, Tiziana Rampello, Giulia Marrone, Nicola Di Daniele, Valentina Rovella
Male obesity secondary hypogonadism (MOSH) impairs fertility, sexual function, bone mineralization, fat metabolism, cognitive function, deteriorates muscle mass and alters body composition. The aim of this pilot study was to evaluate the effect of dietary intervention and physical activity on the MOSH patient's hormonal profile after a 10% weight loss compared to baseline. Fourteen male patients were enrolled. Hormonal, lipid, glycemic profiles and body composition were determined at baseline and after a 10% weight loss...
April 12, 2018: Nutrients
Jaime DeSantiago, Dan J Bare, Disha Varma, R John Solaro, Rishi Arora, Kathrin Banach
BACKGROUND: Atrial fibrillation (AF) is initiated through arrhythmic atrial excitation from outside the sinus node or remodeling of atrial tissue that allows reentry of excitation. Angiotensin II (AngII) has been implicated in initiation and maintenance of AF through changes in Ca2+ handling and production of reactive oxygen species (ROS). OBJECTIVE: We aimed to determine the role of Pak1, a downstream target in the AngII signaling cascade, in atrial electrophysiology and arrhythmia...
April 3, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Céline Pulcini, Francesca Binda, Anjana Sankhil Lamkang, Anna Trett, Esmita Charani, Debra A Goff, Stephan Harbarth, Sylvia Lemos Hinrichsen, Gabriel Levy-Hara, Marc Mendelson, Dilip Nathwani, Revathi Gunturu, Sanjeev Singh, Arjun Srinivasan, Visanu Thamlikitkul, Karin Thursky, Erika Vlieghe, Heiman Wertheim, Mei Zeng, Sumanth Gandra, Ramanan Laxminarayan
OBJECTIVES: With increasing interest in hospital antimicrobial stewardship (AMS) programmes globally, there is a strong demand for core elements of AMS to be clearly defined based on principles of effectiveness and affordability. To date, efforts to identify such core elements have been limited to Europe, Australia, and North America. The aim of this study was to develop a set of core elements and their related checklist items for AMS programmes that should be present in all hospitals, regardless of resource availability, worldwide...
April 2, 2018: Clinical Microbiology and Infection
Fei Tang, Chengan Guo, Xiaoxiao Ma, Jian Zhang, Yuan Su, Ran Tian, Riyi Shi, Yu Xia, Xiaohao Wang, Zheng Ouyang
Rapid and in situ profiling of lipids using ambient mass spectrometry (AMS) techniques has great potential for clinical diagnosis, biological studies and biomarker discovery. In this study, the online photochemical reaction involving carbon-carbon double bonds, was coupled with a surface sampling technique to develop a direct tissue analysis method with specificity to lipid C=C isomers. This method enabled the in situ analysis of lipids from the surface of various tissues or tissue sections, which allowed the structural characterization of lipid isomers within 2 minutes...
April 6, 2018: Analytical Chemistry
Hyun Jun Park, Kyeong Soo Lee, Eun Kyoung Lee, Nam Cheol Park
PURPOSE: The aim of this study was to investigate the efficacy and safety of a mixed extract of Trigonella foenum-graecum seed and Lespedeza cuneata (TFGL) for the treatment of testosterone deficiency syndrome (TDS). MATERIALS AND METHODS: Patients were instructed to take a placebo or 200 mg TFGL capsule twice per day for 8 weeks. The primary efficacy variable was the change from baseline in the Aging Males' Symptoms scale (AMS), as well as levels of serum total and free testosterone...
March 22, 2018: World Journal of Men's Health
Nicola Mondaini, Tommaso Cai, Enrico Sarti, Gaia Polloni, Andrea Gavazzi, Duccio Conti, Andrea Cocci, Maarten Albersen, Gianmartin Cito, Riccardo Bartoletti
PURPOSE: There are many grey areas in the field of penile rehabilitation after radical prostatectomy (RP). The preservation of the full dimensions of the penis is an important consideration for improving patients' compliance for the treatment. We present the first case series of patients treated by laparoscopic extraperitoneal RP and simultaneous penile prosthesis implantation (PPI) in order to preserve the full length of the penis and to improve patients' satisfaction. MATERIALS AND METHODS: From June 2013 to June 2014, 10 patients underwent simultaneous PPI (with an AMS InhibiZone prosthesis) and RP...
January 26, 2018: World Journal of Men's Health
Malina Wagner, Peter Walter, Sabine Salla, Sandra Johnen, Niklas Plange, Stephan Rütten, Tamme W Goecke, Matthias Fuest
PURPOSE: Amniotic membrane (AM) is an essential tool in ocular surface reconstruction. In this study, we analyzed the differential effects of glycerol and straight storage at - 80 °C for up to 6 months on the structural, biological, and mechanical properties of amniotic membrane (AM). METHODS: Human placentae of 11 different subjects were analyzed. AMs were stored at - 80 °C, either with a 1:1 mixture of Dulbecco's modified Eagle medium and glycerol (glycerol) or without any medium or additives (straight)...
April 5, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Ernesto Reyes Villegas, Thomas J Bannan, Michael Le Breton, Archit Mehra, Michael Priestley, Carl Percival, Hugh Coe, James Allan
Food cooking organic aerosols (COA) are one of the main primary sources of submicron particulate matter in urban environments. However, there are still many questions surrounding source apportionment related to instrumentation as well as semi-volatile partitioning as COA evolve rapidly in the ambient air, making source apportionment more complex. Online measurements of emissions from cooking different types of food were performed in a laboratory in order to characterize particles and gases. Aerosol mass spectrometer (AMS) measurements showed that the relative ionization efficiency for OA was higher (1...
April 5, 2018: Environmental Science & Technology
Somi Shin, Hui Jai Lee, Jongwhan Shin, Sejong Lee
OBJECTIVE: Brain computed tomography (CT) is commonly performed to diagnose acute altered mental status (AMS), a critically important symptom in many serious diseases. However, negative CT results are common, which result in unnecessary CT use. Therefore, this study aimed to determine the clinical factors associated with positive CT findings. METHODS: Patients with acute AMS selected from an emergency department-based registry were retrospectively evaluated. Patients with non-traumatic and noncommunicable diseases on initial presentation and with Glasgow Comal Scale scores of <15 were included in the study...
March 2018: Clinical and Experimental Emergency Medicine
Chang Liu, Bao Liu, Lu Liu, Er-Long Zhang, Bind-da Sun, Gang Xu, Jian Chen, Yu-Qi Gao
Background: The modulation of arachidonic acid (AA) metabolism pathway is identified in metabolic alterations after hypoxia exposure, but its biological function is controversial. We aimed at integrating plasma metabolomic and transcriptomic approaches to systematically explore the roles of the AA metabolism pathway in response to acute hypoxia using an acute mountain sickness (AMS) model. Methods: Blood samples were obtained from 53 enrolled subjects before and after exposure to high altitude. Ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry and RNA sequencing were separately performed for metabolomic and transcriptomic profiling, respectively...
2018: Frontiers in Physiology
C Tse, H W Barkema, T J DeVries, J Rushen, E A Pajor
Automatic milking systems (AMS), or milking robots, are becoming widely accepted as a milking technology that reduces labour and increases milk yield. However, reported amount of labour saved, changes in milk yield, and milk quality when transitioning to AMS vary widely. The purpose of this study was to document the impact of adopting AMS on farms with regards to reported changes in milking labour management, milk production, milk quality, and participation in dairy herd improvement (DHI) programmes. A survey was conducted across Canada over the phone, online, and in-person...
April 4, 2018: Animal: An International Journal of Animal Bioscience
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