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https://www.readbyqxmd.com/read/28524014/composition-and-enzymatic-activity-in-bulk-milk-from-dairy-farms-with-conventional-or-robotic-milking-systems
#1
Monika Johansson, Åse Lundh, Ruben de Vries, Kerstin Svennersten Sjaunja
The objective of the studies reported in this research communication was to investigate differences in composition and enzymatic activities in bulk milk samples provided from Swedish dairy farms with different management systems, i.e. automated (AMS) and conventional milking systems (CMS). A bulk milk sample was collected from each of 104 dairy farms, 51 using AMS and 53 using CMS, located in the same geographical region. Sampling took place within two consecutive days during the indoor period (October). Milk samples were analysed for contents of total fat and protein, free fatty acids (FFA), caseins and whey proteins, somatic cell count (SCC), pH, plasmin and plasminogen derived activities, and total proteolysis...
May 2017: Journal of Dairy Research
https://www.readbyqxmd.com/read/28522412/athero-inflammatory-nanotherapeutics-ferulic-acid-based-poly-anhydride-ester-nanoparticles-attenuate-foam-cell-formation-by-regulating-macrophage-lipogenesis-and-reactive-oxygen-species-generation
#2
Rebecca A Chmielowski, Dalia S Abdelhamid, Jonathan J Faig, Latrisha K Petersen, Carol R Gardner, Kathryn E Uhrich, Laurie B Joseph, Prabhas V Moghe
Enhanced bioactive anti-oxidant formulations are critical for treatment of inflammatory diseases, such as atherosclerosis. A hallmark of early atherosclerosis is the uptake of oxidized low density lipoprotein (oxLDL) by macrophages, which results in foam cell and plaque formation in the arterial wall. The hypolipidemic, anti-inflammatory, and antioxidative properties of polyphenol compounds make them attractive targets for treatment of atherosclerosis. However, high concentrations of antioxidants can reverse their anti-atheroprotective properties and cause oxidative stress within the artery...
May 15, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28520865/impact-of-an-integrated-antibiotic-allergy-testing-program-on-antimicrobial-stewardship-a-multicenter-evaluation
#3
Jason A Trubiano, Karin A Thursky, Andrew J Stewardson, Karen Urbancic, Leon J Worth, Cheryl Jackson, Wendy Stevenson, Michael Sutherland, Monica A Slavin, M Lindsay Grayson, Elizabeth J Phillips
Background.: Despite the high prevalence of patient-reported antibiotic allergy (so-called antibiotic allergy labels [AALs]) and their impact on antibiotic prescribing, incorporation of antibiotic allergy testing (AAT) into antimicrobial stewardship (AMS) programs (AAT-AMS) is not widespread. We aimed to evaluate the impact of an AAT-AMS program on AAL prevalence, antibiotic usage, and appropriateness of prescribing. Methods.: AAT-AMS was implemented at two large Australian hospitals during a 14-month period beginning May 2015...
May 18, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28520413/temporal-characteristics-of-brown-carbon-over-the-central-indo-gangetic-plain
#4
Rangu Venkata Satish, Puthukkadan Moosakutty Shamjad, Navaneeth M Thamban, Sachchida N Tripathi, Neeraj Rastogi
Recent global models estimate that light absorption by brown carbon (BrC) in several regions of the world is ~30-70% of that due to black carbon (BC). It is, therefore, important to understand its sources and characteristics on temporal and spatial scale. In this study, we conducted semi-continuous measurements of water-soluble organic carbon (WSOC) and BrC using particle-into-liquid sampler coupled with liquid waveguide capillary cell and total carbon analyzer (PILS-LWCC-TOC) over Kanpur (26.5°N, 80.3°E, 142 m amsl) during a winter season (December 2015 to February 2016)...
May 18, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28509579/findings-of-cognitive-impairment-at-high-altitude-relationships-to-acetazolamide-use-and-acute-mountain-sickness
#5
Lara Phillips, Buddha Basnyat, Yuchiao Chang, Erik R Swenson, N Stuart Harris
Phillips, Lara, Buddha Basnyat, Yuchiao Chang, Erik R. Swenson, and N. Stuart Harris. Findings of cognitive impairment at high altitude: relationships to acetazolamide use and acute mountain sickness. High Alt Med Biol. 00:000-000, 2017.-Objective: Acute mountain sickness (AMS) is defined by patient-reported symptoms using the Lake Louise Score (LLS), which provides limited insight into any possible underlying central nervous system (CNS) dysfunction. Some evidence suggests AMS might coexist with altered neural functioning...
May 16, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28501324/using-a-new-plateau-hyperbaric-chamber-to-alleviate-high-altitude-hypoxia-rabbit-and-human-studies
#6
Liang Sun, Meng-Jiang Ding, Tian-Cai Cai, Hao-Jun Fan, Hong-Mei Gao, Jian-Peng Zhang
OBJECTIVES: To validate the effects of the new plateau hyperbaric chamber on alleviating high altitude hypoxia on Mount Kun Lun. METHODS: A prospective, controlled study of rabbits and adult volunteers was conducted at altitudes of 355, 2880 and 4532m. We obtained arterial blood samples from rabbits and volunteers before and after hyperbaric treatment. The respiratory rate, heart rate, and blood pressure (BP) of adult volunteers were monitored during hyperbaric treatment...
April 19, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28500076/stat5-is-required-for-cd103-dendritic-cell-and-alveolar-macrophage-development-and-protection-from-lung-injury
#7
William E Eddy, Ke-Qin Gong, Bryan Bell, William C Parks, Steven F Ziegler, Anne M Manicone
We tested the role of Stat5 in dendritic cell and alveolar macrophage (AM) homeostasis in the lung using CD11c-cre mediated deletion (Cre(+)5(f/f)). We show that Stat5 is required for CD103(+) dendritic cell and AM development. We found that fetal monocyte maturation into AMs was impaired in Cre(+)5(f/f) mice, and we also confirmed impaired AM development of progenitor cells using mixed chimera experiments. In the absence of Stat5 signaling in AMs, mice developed alveolar proteinosis with altered lipid homeostasis...
May 12, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28499430/genome-wide-dna-methylation-analysis-in-lung-fibroblasts-co-cultured-with-silica-exposed-alveolar-macrophages
#8
Juan Li, Wu Yao, Lin Zhang, Lei Bao, Huiting Chen, Di Wang, Zhongzheng Yue, Yiping Li, Miao Zhang, Changfu Hao
BACKGROUND: Exposure to crystalline silica is considered to increase the risk of lung fibrosis. The primary effector cell, the myofibroblast, plays an important role in the deposition of extracellular matrix (ECM). DNA methylation change is considered to have a potential effect on myofibroblast differentiation. Therefore, the present study was designed to investigate the genome-wide DNA methylation profiles of lung fibroblasts co-cultured with alveolar macrophages exposed to crystalline silica in vitro...
May 12, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28489415/hepatic-steatosis-accompanies-pulmonary-alveolar-proteinosis
#9
Alan N Hunt, Anagha Malur, Tual Monfort, Pavlos Lagoudakis, Sumeet Mahajan, Anthony D Postle, Mary Jane Thomassen
Maintenance of tissue-specific organ lipid compositions characterises mammalian lipid homeostasis. Lung and liver synthesise mixed phosphatidylcholine (PC) molecular species subsequently "tailored" for function. Lungs progressively enrich disaturated PC (DSPC) directed to lamellar body (LB) surfactant stores prior to secretion. Liver accumulates polyunsaturated PC directed to VLDL assembly and secretion, or triglyceride stores. In each tissue, selective PC species enrichment mechanisms lie at the heart of effective homeostasis...
May 10, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/28485654/awareness-and-experience-of-andropause-symptoms-in-men-referring-to-health-centers-a-cross-sectional-study-in-iran
#10
Forough Samipoor, Sedigheh Pakseresht, Parvaneh Rezasoltani, Ehsan Kazemnajad Leili
INTRODUCTION: Andropause is a gradual process and more similar to menopause in women. Knowledge and experience of symptoms of andropause is an important discussion is in their lives. OBJECTIVES: This study aimed to determine Awareness and Experience of Andropause Symptoms in Men referring to Health Centers in Rasht, Iran. MATERIALS AND METHODS: This cross-sectional and analytical study included 140 men over 40 years referring to one of health centers...
May 9, 2017: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/28481626/retinal-hemorrhage-in-a-high-altitude-aid-post-volunteer-doctor-a-case-report
#11
Sanjeeb Sudarshan Bhandari, Pranawa Koirala, Nirajan Regmi, Sushil Pant
Bhandari, Sanjeeb Sudarshan, Pranawa Koirala, Nirajan Regmi, and Sushil Pant. Retinal hemorrhage in a high-altitude aid post volunteer doctor: a case report. High Alt Med Biol 00:000-000, 2017.-High-altitude retinal hemorrhages (HARHs) are seen at altitudes more than 3000 m, are usually multiple, flame shaped, and adjacent to blood vessels. Development near the macula causes blurring of vision, otherwise, they are symptomless and self-limiting. They often develop during the first few days after ascent to high altitude and subjects often suffer from acute mountain sickness (AMS) or high-altitude cerebral edema (HACE)...
May 8, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28479001/prophylactic-acetaminophen-or-ibuprofen-result-in-equivalent-acute-mountain-sickness-incidence-at-high-altitude-a-prospective-randomized-trial
#12
Nicholas C Kanaan, Alicia L Peterson, Matiram Pun, Peter S Holck, Jennifer Starling, Bikash Basyal, Thomas F Freeman, Jessica R Gehner, Linda Keyes, Dana R Levin, Catherine J O'Leary, Katherine E Stuart, Ghan B Thapa, Aditya Tiwari, Jared L Velgersdyk, Ken Zafren, Buddha Basnyat
OBJECTIVE: Recent trials have demonstrated the usefulness of ibuprofen in the prevention of acute mountain sickness (AMS), yet the proposed anti-inflammatory mechanism remains unconfirmed. Acetaminophen and ibuprofen were tested for AMS prevention. We hypothesized that a greater clinical effect would be seen from ibuprofen due to its anti-inflammatory effects compared with acetaminophen's mechanism of possible symptom reduction by predominantly mediating nociception in the brain. METHODS: A double-blind, randomized trial was conducted testing acetaminophen vs ibuprofen for the prevention of AMS...
May 4, 2017: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/28472738/cartilage-lesions-in-feline-stifle-joints-associations-with-articular-mineralizations-and-implications-for-osteoarthritis
#13
Alexandra Leijon, Charles J Ley, Antonia Corin, Cecilia Ley
Feline stifle osteoarthritis (OA) is common, however little is known about the early stages of the disease. Furthermore, the importance of small articular mineralizations (AMs) in feline stifle OA is controversial. This study aimed to describe microscopic articular cartilage lesions and to investigate associations between cartilage lesions and AMs, synovitis, osteochondral junction findings and subchondral bone sclerosis. Stifles of 29 cats, aged 1-23years and euthanized for reasons other than stifle disease, were examined...
April 19, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28470637/-antimicrobial-stewardship-in-daily-life-ask-your-doctor-and-your-pharmacist
#14
Anette Friedrichs, Bibiane Steinborn, Swantje Eisend
Antimicrobial Stewardship (AMS) cannot be practised as a one-man show. A well-established AMS-team with formal authority and dedicated time given by the hospital management can manage its tasks also in exceptional situations as for example an outbreak due to a multi-drug-resistant pathogen. Know-how of clinical infectious diseases is mandatory for all members of the AMS-team. The AMS-team plays various roles in an outbreak situation with the rational use of last-resort antibiotics and optimization of the dosage by therapeutic drug monitoring being most important...
April 2017: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/28470410/the-presence-of-symptoms-of-testosterone-deficiency-in-the-exercise-hypogonadal-male-condition-and-the-role-of-nutrition
#15
David R Hooper, William J Kraemer, Catherine Saenz, Kevin E Schill, Brian C Focht, Jeff S Volek, Carl M Maresh
PURPOSE: High volumes of aerobic exercise have been associated with reduced testosterone (T), known as the exercise-hypogonadal male condition (EHMC). Although the presence of low T has been identified, few studies have assessed the presence of androgen-deficient symptoms. The purpose of this investigation is to assess men exhibiting EHMC and evaluate their hypothalamic-pituitary-gonadal axis, the presence of hypogonadal symptoms, and also investigate a possible contribution of inadequate nutrition to the condition...
May 3, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28463922/ultrasound-screening-for-posterior-shoulder-dislocation-in-infants-with-persistent-brachial-plexus-birth-palsy
#16
Andrea S Bauer, Justin F Lucas, Nasser Heyrani, Ryan L Anderson, Leslie A Kalish, Michelle A James
BACKGROUND: Early detection of posterior shoulder dislocation in infants with brachial plexus birth palsy (BPBP) is essential, but it may be difficult to accomplish with physical examination alone. The aim of this study was to determine the prevalence of shoulder dislocation in patients with BPBP using ultrasound and to identify which physical examination measurements correlated most with dislocation in these patients. METHODS: This study was a retrospective review of data obtained in an ultrasound screening program of infants with BPBP born from January 2011 to April 2014...
May 3, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28458799/the-use-of-bloodstream-infection-mortality-to-measure-the-impact-of-antimicrobial-stewardship-interventions-assessing-the-evidence
#17
REVIEW
Sonali Coulter, Jason A Roberts, Krispin Hajkowicz, Kate Halton
This review sets out to evaluate the current evidence on the impact of inappropriate therapy on bloodstream infections (BSI) and associated mortality. Based on the premise that better prescribing practices should result in better patient outcomes, BSI mortality may be a useful metric to evaluate antimicrobial stewardship (AMS) interventions. A systematic search was performed in key medical databases to identify papers published in English between 2005 and 2015 that examined the association between inappropriate prescribing and BSI mortality in adult patients...
March 30, 2017: Infectious Disease Reports
https://www.readbyqxmd.com/read/28456406/multivariate-dynamic-linear-models-for-estimating-the-effect-of-experimental-interventions-in-an-evolutionary-operations-setup-in-dairy-herds
#18
Anna Helena Stygar, Mogens Agerbo Krogh, Troels Kristensen, Søren Østergaard, Anders Ringgaard Kristensen
Evolutionary operations is a method to exploit the association of often small changes in process variables, planned during systematic experimentation and occurring during the normal production flow, to production characteristics to find a way to alter the production process to be more efficient. The objective of this study was to construct a tool to assess the intervention effect on milk production in an evolutionary operations setup. The method used for this purpose was a dynamic linear model (DLM) with Kalman filtering...
April 26, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28455198/residence-at-moderate-versus-low-altitude-is-effective-at-maintaining-higher-oxygen-saturation-during-exercise-and-reducing-acute-mountain-sickness-following-fast-ascent-to-4559-m
#19
Eva Bernardi, Luca Pomidori, Davide Cavallari, Gaia Mandolesi, Annalisa Cogo
OBJECTIVE: To continuously monitor oxygen saturation (SpO2) by pulse oximeter and assess the development of acute mountain sickness (AMS) using the Lake Louise Score (LLS) during ascent from 1154 to 4559 m in 2 groups of subjects: 10 moderate-altitude residents (MAR; ≥1000-≤2500 m) and 34 low-altitude residents (LAR). MAR are reported to have a lower incidence of AMS during ascent to higher altitudes compared with LAR. Whether this is related to higher SpO2 is still open to debate...
April 25, 2017: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/28450725/heat-shock-protein70-is-implicated-in-modulating-nf-%C3%AE%C2%BAb-activation-in-alveolar-macrophages-of-patients-with-active-pulmonary-tuberculosis
#20
Chun-Hua Wang, Pai-Chien Chou, Fu-Tsai Chung, Horng-Chyuan Lin, Kuo-Hsiung Huang, Han-Pin Kuo
Heat shock proteins (HSPs) have been shown to modulate NF-κB activation. It is unknown whether HSP70 plays a role in modulating NF-κB-mediated pro-inflammatory cytokines released from alveolar macrophage (AM) of patients with active pulmonary tuberculosis (TB). Peripheral blood monocytes (PBMs) and AM were sampled from nineteen active TB patients and 14 healthy individuals. HSP70 expression was 3-fold higher in AMs of active TB patients than normal subjects, and declined after receiving 3-month anti-TB treatment...
April 27, 2017: Scientific Reports
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