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https://www.readbyqxmd.com/read/29035391/a-gammaherpesvirus-provides-protection-against-allergic-asthma-by-inducing-the-replacement-of-resident-alveolar-macrophages-with-regulatory-monocytes
#1
Bénédicte Machiels, Mickael Dourcy, Xue Xiao, Justine Javaux, Claire Mesnil, Catherine Sabatel, Daniel Desmecht, François Lallemand, Philippe Martinive, Hamida Hammad, Martin Guilliams, Benjamin Dewals, Alain Vanderplasschen, Bart N Lambrecht, Fabrice Bureau, Laurent Gillet
The hygiene hypothesis postulates that the recent increase in allergic diseases such as asthma and hay fever observed in Western countries is linked to reduced exposure to childhood infections. Here we investigated how infection with a gammaherpesvirus affected the subsequent development of allergic asthma. We found that murid herpesvirus 4 (MuHV-4) inhibited the development of house dust mite (HDM)-induced experimental asthma by modulating lung innate immune cells. Specifically, infection with MuHV-4 caused the replacement of resident alveolar macrophages (AMs) by monocytes with regulatory functions...
October 16, 2017: Nature Immunology
https://www.readbyqxmd.com/read/29031422/modulation-of-alveolar-macrophage-innate-response-in-proinflammatory-pro-oxidant-and-infection-models-by-mint-extract-and-chemical-constituents-role-of-mapks
#2
Niket Yadav, Harish Chandra
There is a continuing need for discovering novel primary or adjunct therapeutic agents to treat inflammatory conditions and infections. Natural products have inspired the discovery of several modern therapeutics; however, there is a paucity of mechanistic information on their mode of action. This study investigated the therapeutic potential and mode of action of corn mint's (Mentha arvensis) leaf extract (ME) in alveolar macrophages (AMs) challenged with model pro-inflammatory (LPS), pro- oxidant (LPS or H2O2), and infection (Mycobacterium) agents and contribution of its dominant constituents rosmarinic acid, l-menthol, and l-menthone...
October 8, 2017: Immunobiology
https://www.readbyqxmd.com/read/28992800/antimalarial-induced-cardiomyopathy-a-systematic-review-of-the-literature
#3
K Tselios, M Deeb, D D Gladman, P Harvey, M B Urowitz
Background Antimalarials (AMs) are widely used in the treatment of connective tissue diseases. Their main side effect is retinal damage, while heart disease has been described in isolated cases. The aim of this study is to systematically review the existing literature on AM-induced cardiomyopathy (AMIC). Methods The PubMed database was searched for heart biopsy-confirmed AMIC cases. Information on demographics, clinical presentation, concomitant AM-related toxicity, cardiological investigations, treatment and outcome were collected...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28988074/asset-management-to-support-urban-land-and-subsurface-management
#4
Linda Maring, Maaike Blauw
Pressure on urban areas increases by demographic and climate change. To enable healthy, adaptive and liveable urban areas different strategies are needed. One of the strategies is to make better use of subsurface space and its functions. Asset management of the Subsurface (AMS) contributes to this. Asset management provides transparency of trade-offs between performance, cost and risks throughout the entire lifecycle of these assets. AMS is based on traditional asset management methods, but it does not only take man-made assets in the subsurface into account...
October 5, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28987585/producer-estimates-of-prevalence-and-perceived-importance-of-lameness-in-dairy-herds-with-tiestalls-freestalls-and-automated-milking-systems
#5
J H Higginson Cutler, J Rushen, A M de Passillé, J Gibbons, K Orsel, E Pajor, H W Barkema, L Solano, D Pellerin, D Haley, E Vasseur
Lameness is one of the most important welfare and productivity concerns in the dairy industry. Our objectives were to obtain producers' estimates of its prevalence and their perceptions of lameness, and to investigate how producers monitor lameness in tiestall (TS), freestall with milking parlor (FS), and automated milking system (AMS) herds. Forty focal cows per farm in 237 Canadian dairy herds were scored for lameness by trained researchers. On the same day, the producers completed a questionnaire. Mean herd-level prevalence of lameness estimated by producers was 9...
October 4, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28984502/the-association-between-hypogonadism-symptoms-with-serum-testosterone-fsh-and-lh-in-men
#6
Forough Samipoor, Sedigheh Pakseresht, Parvaneh Rezasoltani, Mojtaba Mehrdad
OBJECTIVES: This study aimed to determine the relationship of hypogonadism symptoms with the levels of sex hormones in men. METHODS: This cross-sectional study was conducted on 140 men aged above 40 years. Data collections were conducted by Aging Male Scales (AMS) questionnaire and some sociodemographic variables. Then, 3 ml blood serum was sampled for testosterone (free and total), FSH and LH. Data were analyzed by descriptive and analytical statistics. RESULTS: Mean age score was 52...
October 6, 2017: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/28980133/time-is-nothing-emotional-consistency-of-autobiographical-memory-and-its-neural-basis
#7
Rui Xu, Juan Yang, Chunliang Feng, Haiyan Wu, Ruiwang Huang, Qiuli Yang, Zhihao Li, Pengfei Xu, Ruolei Gu, Yue-Jia Luo
The emotional aspect of autobiographical memories (AMs) is associated with self-related processing, which plays an important role in mental health. However, the emotional consistency dimension of AMs and its neural underpinnings remain largely unexplored. Twenty-five healthy participants were involved in this study. Participants were first asked to recall important AMs and assess the emotional ratings of each AM. Four weeks later, they were asked to retrieve the details of both positive and negative AMs during functional magnetic resonance imaging (fMRI) scanning...
October 4, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28974342/realtime-chemical-characterization-of-post-monsoon-organic-aerosols-in-a-polluted-urban-city-sources-composition-and-comparison-with-other-seasons
#8
Abhishek Chakraborty, Anil Kumar Mandariya, Ruparati Chakraborti, Tarun Gupta, S N Tripathi
Real time chemical characterization of non-refractory submicron aerosols (NR-PM1) was carried out during post monsoon (September-October) via Aerosol Mass Spectrometer (AMS) at a polluted urban location of Kanpur, India. Organic aerosol (OA) was found to be the dominant species with 58% contribution to total NR-PM1 mass, followed by sulfate (16%). Overall, OA was highly oxidized (average O/C = 0.66) with the dominance of oxidized OAs (60% of total OA) as revealed by source apportionment. Oxidized nature of OA was also supported by very high OC/EC ratios (average = 8...
September 30, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28974213/short-term-in-vivo-morphological-changes-of-amniotic-membrane-after-fibrin-glue-assisted-pterygium-surgery-on-anterior-segment-optical-coherence-tomography-a-case-presentation
#9
Jun Hyuk Son, Su-Ho Lim
BACKGROUND: The evaluations of morphological changes of amniotic membrane (AM), even after successful AM transplantation surgery without complications, may be difficult. Moreover, there was no report regarding morphological changes after fibrin glue-assisted AM transplantation with pterygium excision. Here, we highlight and describe the use of spectral domain optical coherence tomography (OCT) for the evaluation of the morphological features of amniotic membrane (AM) and of associated in vivo structural changes after fibrin glue-assisted pterygium surgery...
October 3, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28967063/comparative-study-of-urodynamic-tests-after-ams-800-and-zsi-375-insertion
#10
Thomas Ripert, Jean Pierrevelcin
STUDY DESIGN: Retrospective, non-randomised, single-centre study. OBJECTIVES: Comparative study of urodynamic tests in patients presenting social continence after AMS 800 or ZSI 375 insertion. MATERIALS AND METHODS: Study was open to patients with social continence, implanted with AMS 800 or ZSI 375. Vesical pressure (VP), urethral functional length (FL), maximal urethral pressure (MUP), maximal urethral closure pressure (MUCP), maximal urinary flow rate (Qmax) were registered with standard urodynamic equipment...
September 21, 2017: Urologia
https://www.readbyqxmd.com/read/28965656/effects-of-binge-alcohol-exposure-on-burkholderia-thailandensis-alveolar-macrophage-interaction
#11
Victor Jimenez, Ryan Moreno, Emily Kaufman, Heidie Hornstra, Erik Settles, Bart J Currie, Paul Keim, Fernando P Monroy
Alcohol consumption has diverse and well-documented effects on the human immune system and its ability to defend against infective agents. One example is melioidosis, a disease caused by infection with Burkholderia pseudomallei, which is of public health importance in Southeast Asia and Northern Australia, with an expanding global distribution. While B. pseudomallei infections can occur in healthy humans, binge alcohol use is progressively being recognized as a major risk factor. Although binge alcohol consumption has been considered as a risk factor for the development of melioidosis, no experimental studies have investigated the outcomes of alcohol exposure on Burkholderia spp...
November 2017: Alcohol
https://www.readbyqxmd.com/read/28964239/magnetoencephalography-with-a-cs-based-high-sensitivity-compact-atomic-magnetometer
#12
Jingwei Sheng, Shuangai Wan, Yifan Sun, Rongshe Dou, Yuhao Guo, Kequan Wei, Kaiyan He, Jie Qin, Jia-Hong Gao
In recent years, substantial progress has been made in developing a new generation of magnetoencephalography (MEG) with a spin-exchange relaxation free (SERF)-based atomic magnetometer (AM). An AM employs alkali atoms to detect weak magnetic fields. A compact AM array with high sensitivity is crucial to the design; however, most proposed compact AMs are potassium (K)- or rubidium (Rb)-based with single beam configurations. In the present study, a pump-probe two beam configuration with a Cesium (Cs)-based AM (Cs-AM) is introduced to detect human neuronal magnetic fields...
September 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28957834/use-of-self-retained-cryopreserved-amniotic-membrane-in-the-treatment-of-acute-chemical-ocular-burn
#13
Adam T Shupe, Anny M S Cheng
SIGNIFICANCE: Ocular chemical injury is a medical emergency in which immediate treatment is critical to prevent visual morbidity. We report a severe ocular burn case that illustrates in-office management to promote rapid re-epithelialization and reduce inflammation to restore ocular surface integrity. PURPOSE: To report a case of severe acid burn that was managed successfully with self-retained cryopreserved amniotic membrane (AM). METHODS: A 43-year-old man presented with complaints of pain, light sensitivity, and blurred vision in both eyes 1 day after ocular exposure to acid...
September 27, 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28956697/annurca-apple-nutraceutical-formulation-enhances-keratin-expression-in-a-human-model-of-skin-and-promotes-hair-growth-and-tropism-in-a-randomized-clinical-trial
#14
Gian Carlo Tenore, Domenico Caruso, Giuseppe Buonomo, Maria D'Avino, Rita Santamaria, Carlo Irace, Marialuisa Piccolo, Maria Maisto, Ettore Novellino
Several pharmaceutical products have been formulated over the past decades for the treatment of male and female alopecia, and pattern baldness, but relatively few metadata on their efficacy have been published. For these reasons, the pharmaceutical and medical attention has recently focused on the discovery of new and safer remedies. Particularly, great interest has been attracted by oligomeric procyanidin bioactivity, able to promote hair epithelial cell growth as well as to induce the anagen phase. Specifically, the procyanidin B2, a dimeric derivative extracted from apples, has demonstrated to be one of the most effective and safest natural compounds in promoting hair growth, both in vitro and in humans by topical applications...
September 28, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28955355/gene-regulatory-network-for-tapetum-development-in-arabidopsis-thaliana
#15
Dan-Dan Li, Jing-Shi Xue, Jun Zhu, Zhong-Nan Yang
In flowering plants, male gametophyte development occurs in the anther. Tapetum, the innermost of the four anther somatic layers, surrounds the developing reproductive cells to provide materials for pollen development. A genetic pathway of DYT1-TDF1-AMS-MS188 in regulating tapetum development has been proven. Here we used laser microdissection and pressure catapulting to capture and analyze the transcriptome data for the Arabidopsis tapetum at two stages. With a comprehensive analysis by the microarray data of dyt1, tdf1, ams, and ms188 mutants, we identified possible downstream genes for each transcription factor...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28951163/dynamic-changes-in-large-scale-functional-network-organization-during-autobiographical-memory-retrieval
#16
Cory S Inman, G Andrew James, Katherine Vytal, Stephan Hamann
Autobiographical memory (AM), episodic memory for life events, involves the orchestration of multiple dynamic cognitive processes, including memory access and subsequent elaboration. Previous neuroimaging studies have contrasted memory access and elaboration processes in terms of regional brain activation and connectivity within large, multi-region networks. Although interactions between key memory-related regions such as the hippocampus and prefrontal cortex (PFC) have been shown to play an important role in AM retrieval, it remains unclear how such connectivity between specific, individual regions involved in AM retrieval changes dynamically across the retrieval process and how these changes relate to broader memory networks throughout the whole brain...
September 23, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28947454/relationship-of-altitude-mountain-sickness-and-smoking-a-catalan-traveller-s-cohort-study
#17
Alba Sánchez-Mascuñano, Cristina Masuet-Aumatell, Sergio Morchón-Ramos, Josep M Ramon
OBJECTIVES: The aim of this study is to analyse the relationship between smoking and altitude mountain sickness in a cohort of travellers to 2500 metres above sea level (masl) or higher. SETTING: Travel Health Clinic at the Hospital Universitari de Bellvitge, in Barcelona, Spain. PARTICIPANTS: A total of 302 adults seeking medical advice at the travel clinic, between July 2012 and August 2014, before travelling to 2500 masl or above, who agreed to participate in the study and to be contacted after the trip were included...
September 24, 2017: BMJ Open
https://www.readbyqxmd.com/read/28940573/positive-regulation-of-ams-by-tdf1-and-the-formation-of-a-tdf1-ams-complex-are-required-for-anther-development-in-arabidopsis-thaliana
#18
Yue Lou, Hai-Sheng Zhou, Yu Han, Qiu-Ye Zeng, Jun Zhu, Zhong-Nan Yang
Tapetum development and pollen production are regulated by a complex transcriptional network that consists of a group of tapetum-specific Arabidopsis transcription factors (TFs). Among these TFs, DEFECTIVE IN TAPETAL DEVELOPMENT AND FUNCTION 1 (TDF1) encodes an R2R3 MYB factor, and ABORTED MICROSPORE (AMS) encodes a basic helix-loop-helix (bHLH) factor. However, knowledge regarding the regulatory role of TDF1 in anther development remains limited. Here, we discovered that TDF1 directly regulates AMS via an AACCT cis-element...
September 20, 2017: New Phytologist
https://www.readbyqxmd.com/read/28935404/chemical-characteristics-and-sources-of-pm1-during-the-2016-summer-in-hangzhou
#19
Kangwei Li, Linghong Chen, Stephen J White, Xianjue Zheng, Biao Lv, Chao Lin, Zhier Bao, Xuecheng Wu, Xiang Gao, Fang Ying, Jiandong Shen, Merched Azzi, Kefa Cen
During the 2016 Hangzhou G20 Summit, the chemical composition of submicron particles (PM1) was measured by a High-Resolution Time-of-Flight Aerosol Mass Spectrometer (HR-ToF-AMS) along with a suite of collocated instruments. The campaign was undertaken between August 5 and September 23, 2016. The impacts of emission controls and meteorological conditions on PM1 chemical composition, diurnal cycles, organic aerosol (OA) source apportionment, size distribution and elemental ratios were characterized in detail...
September 19, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28930085/importation-of-cyhv-2-infected-goldfish-into-the-netherlands
#20
Takafumi Ito, Jun Kurita, Olga L M Haenen
Cyprinid herpesvirus 2 (CyHV-2) is known as the causative agent of herpesviral haematopoietic necrosis in goldfish Carassius auratus auratus. However, the virus has also been detected in Prussian carp C. gibelio and crucian carp C. carassius from European and Asian countries. To prevent spread of the causative virus to other areas, investigation of the risk factors of spread of this virus is important. In this study, 8 batches of goldfish imported into the Netherlands by airfreight from Asia and the Middle East were investigated for the presence of the virus...
September 20, 2017: Diseases of Aquatic Organisms
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