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https://www.readbyqxmd.com/read/28239990/full-length-sequences-of-3-hla-b-56-alleles-b-56-01-01-01-b-56-03-and-b-56-04-confirmed-by-cloning-and-sequencing
#1
Z Li, H-Y Zou
Full-length sequences of HLA-B*56:01:01:01, B*56:03 and B*56:04, confirmed by cloning and sequencing in Chinese donors.
February 26, 2017: HLA
https://www.readbyqxmd.com/read/28239987/effects-of-alloantibodies-to-human-leukocyte-antigen-on-endothelial-expression-and-serum-levels-of-thrombomodulin
#2
Stéphanie Béland, Patrice Vallin, Olivier Désy, Eric Lévesque, Sacha A De Serres
RATIONALE: Thrombomodulin (TBM) is an anticoagulant and anti-inflammatory transmembrane protein expressed on endothelial cells. Donor-specific alloantibodies, particularly those against human leukocyte antigen (HLA) class II, are associated with microvascular endothelial damage in solid allografts. OBJECTIVE: Our aim was to characterize the effects of anti-HLA antibodies on endothelial expression of TBM, and in particular, the differential effects of anti-HLA class I compared with those of anti-HLA class II...
February 26, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28239955/the-novel-hla-drb1-15-140-allele-discovered-in-a-taiwanese-unrelated-hematopoietic-stem-cell-donor
#3
K L Yang, J Ng, A Lazaro, P Y Lin
One nucleotide substitution at residue 91 of HLA-DRB1*15:02:01:01 results in a new allele, HLA-DRB1*15:140.
February 26, 2017: HLA
https://www.readbyqxmd.com/read/28239947/analysis-of-early-hepatic-artery-thrombosis-after-liver-transplantation
#4
Zhicheng Xue, Maogen Chen, Xuzhi Zhang, Guodong Wang, Xiaoshun He, Linwei Wu, Yi Ma
BACKGROUND: Hepatic artery thrombosis (HAT) is one of the deadliest complications after orthotopic liver transplantation (OLT). This study aimed to identify risk factors and summarize the experience of HAT management after OLT. METHODS: Clinical data of 407 adult patients who received OLT in our centres from July 2011 to December 2015 were retrospectively investigated. RESULTS: The incidence rate of early HAT was 2.0% (8/407). Recipient/donor weight ratio ≥1...
February 27, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28239914/-d-10-meld-as-a-novel-predictor-of-patient-and-graft-survival-after-adult-to-adult-living-donor-liver-transplantation
#5
Arvinder Singh Soin, Sanjay Goja, Sanjay Kumar Yadav, Tseten Yonjen Tamang, Amit Rastogi, Prashant Bhangui, S Thiagrajan, Vikram Raut, Raghvendra Y Babu, Neeraj Saraf, Narendra Singh Chaudhary, Vijay Vohara
We modified the previously described DMELD score in deceased donor liver transplant, to (D+10)MELD to account for living donors being about 10 years younger than deceased donors, and tested it on living donor liver transplantation (LDLT) recipients. 500 consecutive LDLT, between July 2010 and December 2012 were retrospectively analyzed to see the effect of (D+10)MELD on patient and graft survival. Donor age alone did not influence survival. Recipients were divided into 6 classes on based on the (D+10)MELD score: Class 1 (0-399), Class 2 (400-799), Class 3 (800-1199), class 4 (1200-1599), Class 5 (1600-1999) and Class 6 (>2000)...
February 26, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28239909/ledipasvir-sofosbuvir-is-effective-and-well-tolerated-in-post-kidney-transplant-patients-with-chronic-hepatitis-c-virus
#6
Amilcar L Morales, Luz Liriano-Ward, Amber Tierney, Michelle Sang, Alexander Lalos, Mohamed Hassan, Vinay Nair, Thomas Schiano, Rohit Satoskar, Coleman Smith
Patients with end stage renal diseases on hemodialysis have a high prevalence of hepatitis C infection (HCV). In most patients treatment for HCV is delayed until post renal transplant. We assessed the effectiveness and tolerance of ledipasvir/sofosbuvir (LDV/SOF) in 32 post-kidney transplant patients infected with HCV. The group was composed predominantly of treatment naïve (75%) African American (68.75%) males (75%) infected with genotype 1a (62.5%). Most patients received a deceased donor kidney graft (78...
February 26, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28239787/heterogeneity-of-retinal-pigment-epithelial-cells-from-adult-human-eye-in-different-culturing-systems
#7
A V Kuznetsova, M A Aleksandrova
We studied the behavior of retinal pigment epithelial cells from adult human eye derived from different donors in different culturing systems: on plastic, in collagen gel, and on decellularized neural retina substrate. The cells diverge into two subpopulations similar by their morphology and behavior: one subpopulation migrated to the surface of the dense substrate and the other formed spheroid structures consisting of aggregated cells. This fact confirms the data on genetically-predetermined phenotypic heterogeneity of retinal pigment epithelium cells that should be taken into account when using these cells in tissue engineering...
February 27, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28239738/organic-photodiodes-from-homochiral-l-proline-derived-squaraine-compounds-with-strong-circular-dichroism
#8
Matthias Schulz, Majvor Mack, Oliver Kolloge, Arne Lützen, Manuela Schiek
We suggest and explore a novel route towards organic photodetectors sensitive to the circular polarization state of light. For this, we insert fullerene-blended thin films of homochiral squaraine compounds acting as a highly circular dichroic active layer into conventional bulk hetero-junction photodiodes. Initially, we discuss steady-state characterization of photodiodes with unpolarized light. The homochiral, l-proline derived squaraine compounds are obtained via a chiral pool synthesis in sizable quantities...
February 27, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28239736/ferrocene-diketopyrrolopyrrole-based-small-molecule-donors-for-bulk-heterojunction-solar-cells
#9
Yuvraj Patil, Rajneesh Misra, Manish Kumar Singh, Ganesh D Sharma
A symmetrical D-π-A-π-D type small molecule consisting of thiophene flanked diketopyrrolopyrrole (DPP) as a core and an end capping ferrocene donor linked by an ethynyl bridge, denoted as Fc-DPP-Fc, was synthesized and its optical, thermal and electrochemical properties were investigated in order to explore its potential applicability as a donor for solution processed bulk heterojunction solar cells. The photophysical and electrochemical properties of this small molecule showed strong charge transfer interaction between the ferrocene donor and the DPP acceptor, and it is found to be suitable as a small molecule donor along with PC71BM as an electron acceptor for solution processed bulk heterojunction organic solar cells (OSCs)...
February 27, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28239733/evidence-of-robust-participation-by-an-equatorial-4-o-group-in-glycosylation-on-a-2-azido-2-deoxy-glucopyranosyl-donor
#10
Dongming Yao, Yichu Liu, Shiqiang Yan, Yingxia Li, Chun Hu, Ning Ding
Although there are numerous claims of remote group participation leading to the synthesis of the expected glycosides with improved anomeric geometry outcome in glycosylation, there is still a lack of enough strong evidence and this has led to a long-term debate, particularly for equatorial 4-O group participation. In this work, we were able to synthesize and isolate a stable seven-membered trichlorooxazepine ring bridging intermediate with a high yield by employing a 2-azido-2-deoxy-glucopyranosyl donor, which provides strong evidence to support the putative participation of the equatorial 4-O group in glycosylation...
February 27, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28239706/structure-and-dynamic-nmr-behavior-of-rhodium-complexes-supported-by-lewis-acidic-group-13-metallatranes
#11
James T Moore, Nicholas E Smith, Connie C Lu
Monovalent Rh was installed into the group 13 metallatranes, M[N(o-(NCH2P((i)Pr)2)C6H4)3] (where M = Al and Ga, abbreviated as ML) to generate Rh → M bonds in the parent complexes, Cl-RhAlL (1-Cl) and Cl-RhGaL (2-Cl). The electron-withdrawing nature of the group 13 metalloids was probed by cyclic voltammetry, and Rh-Ga was found to be more electron-deficient than Rh-Al (Epc = -2.07 and -1.95 V vs. Fc(+)/Fc for 1-Cl and 2-Cl, respectively). Both 1-Cl and 2-Cl were further functionalized through metathesis reactions using MeLi to generate 1-CH3 and 2-CH3, respectively, or using LiHBEt3 to form 1-H and 2-H, respectively...
February 27, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28239691/wood-combustion-particles-induce-adverse-effects-to-normal-and-diseased-airway-epithelia
#12
Manuel Krapf, Lisa Künzi, Sandrine Allenbach, Emily A Bruns, Ilaria Gavarini, Imad El-Haddad, Jay G Slowik, André S H Prévôt, Luka Drinovec, Griša Močnik, Lutz Dümbgen, Matthias Salathe, Nathalie Baumlin, Constantinos Sioutas, Urs Baltensperger, Josef Dommen, Marianne Geiser
Residential wood burning is a major source of poorly characterized, deleterious particulate matter, whose composition and toxicity may vary with wood type, burning condition and photochemical age. The causative link between ambient wood particle constituents and observed adverse health effects is currently lacking. Here we investigate the relationship between chemical properties of primary and atmospherically aged wood combustion particles and acute toxicity in human airway epithelial cells. Emissions from a log wood burner were diluted and injected into a smog chamber for photochemical aging...
February 27, 2017: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/28239678/bidirectional-intragraft-alloreactivity-drives-the-repopulation-of-human-intestinal-allografts-and-correlates-with-clinical-outcome
#13
Julien Zuber, Brittany Shonts, Sai-Ping Lau, Aleksandar Obradovic, Jianing Fu, Suxiao Yang, Marion Lambert, Shana Coley, Joshua Weiner, Joseph Thome, Susan DeWolf, Donna L Farber, Yufeng Shen, Sophie Caillat-Zucman, Govind Bhagat, Adam Griesemer, Mercedes Martinez, Tomoaki Kato, Megan Sykes
A paradigm in transplantation states that graft-infiltrating T cells are largely non-alloreactive "bystander" cells. However, the origin and specificity of allograft T cells over time has not been investigated in detail in animals or humans. Here, we use polychromatic flow cytometry and high throughput TCR sequencing of serial biopsies to show that gut-resident T cell turnover kinetics in human intestinal allografts are correlated with the balance between intra-graft host-vs-graft (HvG) and graft-vs-host (GvH) reactivities and with clinical outcomes...
October 2016: Science Immunology
https://www.readbyqxmd.com/read/28239644/hla-dq-%C3%AE-1-alleles-associated-with-epstein-barr-virus-ebv-infectivity-and-ebv-gp42-binding-to-cells
#14
Qingxue Li, Wei Bu, Erin Gabriel, Fiona Aguilar, Yo Hoshino, Hiroko Miyadera, Christoph Hess, Ronald L Hornung, Amitava Roy, Jeffrey I Cohen
Epstein-Barr virus (EBV) infects B cells and ~95% of adults are infected. EBV glycoprotein gp42 is essential for entry of virus into B cells. EBV gp42 binds to the β1 chain of HLA-DQ, -DR, and -DP on B cells, and uses these molecules for infection. To investigate if certain HLA-DQ alleles are associated with EBV seronegativity, we recruited ~3,300 healthy adult blood donors, identified 106 EBV-seronegative individuals, and randomly selected a control group of EBV-seropositive donors from the donor pool. A larger than expected proportion of EBV-seronegative subjects were HLA-DQ β1 *04/*05 and *06/*06, and to a lesser extent, *02/*03, compared with the control group, while a larger than expected portion of EBV-seropositive persons were HLA-DQ β1 *02/*02...
February 23, 2017: JCI Insight
https://www.readbyqxmd.com/read/28239573/role-of-buccal-pad-of-fat-in-reconstruction-of-the-buccal-mucosa-defects
#15
A Sagayaraj, N Divya Jyothi, S M Azeem Mohiyuddin, Ravindra P Deo, B Vageesh Padiyar
Carcinoma buccal mucosa is the most common oral cavity cancer in India. Following excision of these lesions the defects can be reconstructed using various reconstructive techniques. Buccal pad of fat has been successfully used in the reconstruction of small palatal defects and in the closure of the oro antral fistula. This study aims at evaluating the role of buccal pad of fat in reconstruction of defects following excision of the small to medium premalignant lesions and T1-T2 malignant lesions of buccal mucosa...
March 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28239529/morphological-relationship-between-the-superior-cervical-ganglion-and-cervical-nerves-in-japanese-cadaver-donors
#16
Kazuyuki Mitsuoka, Takeshi Kikutani, Iwao Sato
INTRODUCTION: There are various communications between the superior cervical ganglion (SCG) and the vagus and glossopharyngeal nerves. However, little information exists concerning the origin of these sympathetic ganglion branches at the superior, middle, and inferior regions of the human SCG. The aim of this study was to describe the human SCG in a morphometric manner with the communication with cranial and cervical nerves and supply. METHODS: This study characterized 72 SCG samples from 54 elderly Japanese human cadavers (30 males, 24 females; 65-100 years old)...
February 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28239472/analyses-of-the-peripheral-immunome-following-multiple-administrations-of-avelumab-a-human-igg1-anti-pd-l1-monoclonal-antibody
#17
Renee N Donahue, Lauren M Lepone, Italia Grenga, Caroline Jochems, Massimo Fantini, Ravi A Madan, Christopher R Heery, James L Gulley, Jeffrey Schlom
BACKGROUND: Multiple anti-PD-L1/PD-1 checkpoint monoclonal antibodies (MAb) have shown clear evidence of clinical benefit. All except one have been designed or engineered to omit the possibility to mediate antibody-dependent cell-mediated cytotoxicity (ADCC) as a second potential mode of anti-tumor activity; the reason for this is the concern of lysis of PD-L1 positive immune cells. Avelumab is a fully human IgG1 MAb which has been shown in prior in vitro studies to mediate ADCC versus a range of human tumor cells, and clinical studies have demonstrated anti-tumor activity versus a range of human cancers...
2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28239380/development-of-three-different-nk-cell-subpopulations-during-immune-reconstitution-after-pediatric-allogeneic-hematopoietic-stem-cell-transplantation-prognostic-markers-in-gvhd-and-viral-infections
#18
Sabine Huenecke, Claudia Cappel, Ruth Esser, Verena Pfirrmann, Emilia Salzmann-Manrique, Sibille Betz, Eileen Keitl, Julia Banisharif-Dehkordi, Shahrzad Bakhtiar, Christoph Königs, Andrea Jarisch, Jan Soerensen, Evelyn Ullrich, Thomas Klingebiel, Peter Bader, Melanie Bremm
Natural killer (NK) cells play an important role following allogeneic hematopoietic stem cell transplantation (HSCT) exerting graft-versus-leukemia/tumor effect and mediating pathogen-specific immunity. Although NK cells are the first donor-derived lymphocytes reconstituting post-HSCT, their distribution of CD56(++)CD16(-) (CD56(bright)), CD56(++)CD16(+) (CD56(intermediate=int)), and CD56(+)CD16(++) (CD56(dim)) NK cells is explicitly divergent from healthy adults, but to some extent comparable to the NK cell development in early childhood...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28239315/single-fecal-microbiota-transplantation-failed-to-change-intestinal-microbiota-and-had-limited-effectiveness-against-ulcerative-colitis-in-japanese-patients
#19
Shinta Mizuno, Kosaku Nanki, Katsuyoshi Matsuoka, Keiichiro Saigusa, Keiko Ono, Mari Arai, Shinya Sugimoto, Hiroki Kiyohara, Moeko Nakashima, Kozue Takeshita, Makoto Naganuma, Wataru Suda, Masahira Hattori, Takanori Kanai
BACKGROUND/AIMS: Recent developments in analytical techniques including next-generation sequencing have clarified the correlation between intestinal microbiota and inflammatory bowel disease. Fecal microbiota transplantation (FMT) for patients with ulcerative colitis (UC) is proposed as a potential approach to resolving their dysbiosis; however, its safety and efficacy have not been confirmed. This single-arm, open-label, non-randomized study aimed to evaluate the safety and efficacy of FMT for Japanese patients with UC as the first registered clinical trial in Japan...
January 2017: Intestinal Research
https://www.readbyqxmd.com/read/28238813/genomewide-bisulfite-sequencing-reveals-the-origin-and-time-dependent-fragmentation-of-urinary-cfdna
#20
Timothy H T Cheng, Peiyong Jiang, Jacqueline C W Tam, Xiao Sun, Wing-Shan Lee, Stephanie C Y Yu, Jeremy Y C Teoh, Peter K F Chiu, Chi-Fai Ng, Kai-Ming Chow, Cheuk-Chun Szeto, K C Allen Chan, Rossa W K Chiu, Y M Dennis Lo
Urinary cell-free (cf) DNA holds great potential as a completely noninvasive form of liquid biopsy. Knowledge of the composition of cfDNA by tissue of origin is useful for guiding its clinical uses. We conducted a global survey of urinary cfDNA composition using genomewide bisulfite sequencing. While previous studies focused on detecting cfDNA from a single source at a time, genomewide tissue specific methylation signatures allow us to simultaneously deduce the proportional contribution from each contributing tissue...
February 23, 2017: Clinical Biochemistry
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