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https://www.readbyqxmd.com/read/29656549/sodium-nitroprusside-is-effective-in-preventing-and-or-reversing-the-development-of-schizophrenia-related-behaviors-in-an-animal-model-the-shr-strain
#1
Mariana C Diana, Fernanda F Peres, Veronica Justi, Rodrigo A Bressan, Acioly L T Lacerda, José Alexandre Crippa, Jaime E C Hallak, Vanesssa Costhek Abilio
AIMS: The treatment of schizophrenia with antipsychotics is still unsatisfactory. Therefore, the search for new treatments and prevention is crucial, and animal models are fundamental tools for this objective. Preclinical and clinical data evidence the antipsychotic profile of sodium nitroprusside (SNP), a nitric oxide (NO) donor. We aimed to investigate SNP in treating and/or preventing the schizophrenia-related behaviors presented by the spontaneously hypertensive rats (SHR) strain...
April 14, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29656530/mycobacterium-tuberculosis-after-solid-organ-transplantation-a-review-of-more-than-2000-cases
#2
Cybele Lara R Abad, Raymund R Razonable
BACKGROUND: Mycobacterium tuberculosis (TB) is a common pathogen worldwide, and it may cause significant infection after solid organ transplantation (SOT). We reviewed all reported TB cases to provide an update on its epidemiology, clinical presentation, management and outcome after SOT. METHODS: MEDLINE, EMBASE, and OVID were reviewed from January 1, 1998 to Dec 31, 2016 using key words tuberculosis and solid organ transplant or transplantation. RESULTS: There were 187 publications reporting 2082 cases of TB among kidney (n=1719), liver (n=253), heart (n=77), lung (n=25), and kidney-pancreas (n=8) recipients...
April 15, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29656499/matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry-analysis-of-36-blood-group-alleles-among-396-thai-samples-reveals-region-specific-variants
#3
Philaiphon Jongruamklang, Christoph Gassner, Stefan Meyer, Aksarakorn Kummasook, Marion Darlison, Chayanun Boonlum, Surin Chanta, Beat M Frey, Martin L Olsson, Jill R Storry
BACKGROUND: Blood group phenotype variation has been attributed to potential resistance to pathogen invasion. Variation was mapped in blood donors from Lampang (northern region) and Saraburi (central region), Thailand, where malaria is endemic. The previously unknown blood group allele profiles were characterized and the data were correlated with phenotypes. The high incidence of the Vel-negative phenotype previously reported in Thais was investigated. STUDY DESIGN AND METHODS: DNA from 396 blood donors was analyzed by matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry...
April 15, 2018: Transfusion
https://www.readbyqxmd.com/read/29656391/proteomic-analysis-of-sperm-proteins-in-infertile-men-with-high-levels-of-reactive-oxygen-species
#4
A Ayaz, A Agarwal, R Sharma, N Kothandaraman, Z Cakar, S Sikka
Oxidative stress is a significant risk factor for male infertility. A pro-oxidant testicular environment may alter the expression profile of functional sperm proteins and result in poor sperm quality. Patients and donors were divided into ROS (-) and ROS (+) groups. Using computational studies, and data mining of available literature on spermatozoa, oxidative stress and proteomics, we identified three core regulatory proteins angiotensin-converting enzyme (ACE), heat-shock protein (Hsp70) family A member 2 (HSPA2) and ribosomal protein subunit 27A (RPS27A) and seven interlink proteins NOS2, SUMO2, UBL4A, FBXO25, MAP3K3, APP and UBC...
April 15, 2018: Andrologia
https://www.readbyqxmd.com/read/29656333/interferon-%C3%AE-salvage-treatment-is-effective-for-patients-with-acute-leukemia-myelodysplastic-syndrome-with-unsatisfactory-response-to-minimal-residual-disease-directed-donor-lymphocyte-infusion-after-allogeneic-hematopoietic-stem-cell-transplantation
#5
Xiaodong Mo, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang
The efficacy of salvage interferon-α (IFN-α) treatment was investigated in patients with unsatisfactory response to minimal residual disease (MRD)-directed donor lymphocyte infusion (DLI) (n = 24). Patients who did not become MRD-negative at 1 month after DLI were those with unsatisfactory response and were eligible to receive salvage IFN-α treatment within 3 months of DLI. Recombinant human IFN-α-2b injections were subcutaneously administered 2-3 times a week for 6 months. Nine (37.5%), 6 (25.0%), and 3 (12...
April 14, 2018: Frontiers of Medicine
https://www.readbyqxmd.com/read/29656291/activin-a-is-a-pro-inflammatory-regulator-in-type-2-driven-upper-airway-disease
#6
Adam M Chaker, Ulrich Matthias Zissler, Nikolaos Poulos, Martin Wagenmann, Murat Bas, Ferdinand Gürth, Georgina Xanthou, Carsten Schmidt-Weber
BACKGROUND: Allergic upper airway disease involves pro-inflammatory type-2 cytokines such as IL-5 and regulatory tissue repair mediators, in particular transforming growth factor (TGF)-β1. The TGF-β-superfamily member activin-A displays multiple biological functions and shares certain signalling pathways with TGF-β1. We aimed to examine the coregulation of mucosal activin-A and TGF-β1 in acute allergic and chronic Th2-driven upper airway disease. METHODS: We investigated mucosal cytokine expression profiles and kinetics using RT-PCR after nasal allergen challenges in patients with seasonal allergic rhinitis...
April 13, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29656138/impdh-pharmacogenetics-in-hematopoietic-cell-transplantation-patients
#7
Jeannine S McCune, Barry Storer, Sushma Thomas, Jožefa McKiernan, Rohan Gupta, Brenda M Sandmaier
We evaluated inosine monophosphate dehydrogenase (IMPDH) 1 and IMPDH2 pharmacogenetics in 247 recipient-donor pairs after nonmyeloablative hematopoietic cell transplant (HCT) recipients. Patients were conditioned with total body irradiation + fludarabine, received grafts from related or unrelated donors (10% HLA mismatch), with post-graft immunosuppression of mycophenolate mofetil (MMF) with a calcineurin inhibitor. Recipient and donor IMPDH genotype (rs11706052, rs2278294, rs2278293) were not associated with day 28 T-cell chimerism, acute graft versus host disease, disease relapse, cytomegalovirus reactivation, non-relapse mortality, or overall survival...
April 12, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29656137/haploidentical-peripheral-blood-stem-cell-transplantation-demonstrates-stable-engraftment-in-adults-with-sickle-cell-disease
#8
Santosh L Saraf, Annie L Oh, Pritesh R Patel, Karen Sweiss, Matthew Koshy, Sally Campbell-Lee, Michel Gowhari, Shivi Jain, David Peace, John G Quigley, Irum Khan, Robert E Molokie, Nadim Mahmud, Victor R Gordeuk, Damiano Rondelli
We report on the screening and development of haploidentical hematopoietic stem cell transplantation (HSCT) for adult patients with clinically aggressive sickle cell disease (SCD) at our institution. Of 50 adult SCD patients referred for HSCT between 1/2014-3/2017, 20% were denied by insurance. Of 41 patients initially screened, 10% lacked an available haploidentical donor, 29% had elevated donor specific antibodies (DSA) and 34% declined to proceed to HSCT. All 10 patients who were transplanted received peripheral blood stem cells (PBSC)...
April 12, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29655872/-contribution-of-the-scrotal-flap-for-the-coverage-of-ischial-and-perineal-pressure-ulcers
#9
M Vantomme, R Viard, R Aimard, P-L Vincent, J-P Comparin, D Voulliaume
INTRODUCTION: The ischiatric pressure sore is a common pathology in rehabilitated spinal cord injured people, despite careful prevention. Medical treatment by discharge and directed healing is not always sufficient and surgery using local musculocutaneous flaps is often essential. Unfortunately, recidivism is frequent and the availability of local flaps is limited. The scrotal flap is an excellent complement to classic flaps, gluteal flaps or hamstrings. It can be used alone or in addition to another musculocutaneous flap, in first or second intention...
April 11, 2018: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/29655664/a-retrospective-investigation-of-abdominal-visceral-fat-body-mass-index-bmi-and-active-smoking-as-risk-factors-for-donor-site-wound-healing-complications-after-free-diep-flap-breast-reconstructions
#10
Floyd W Timmermans, Pèdrou B Westland, Stefan Hummelink, Joep Schreurs, Marijn Hameeteman, Dietmar J O Ulrich, Nicholas J Slater
BACKGROUND: The deep inferior epigastric artery perforator (DIEP) flap is one of the most common techniques for breast reconstruction. Body mass index (BMI) is considered as an important predictor of donor site healing complications such as wound dehiscence. The use of computed tomography (CT) proved to be a precise and objective method to assess visceral adipose tissue. It remains unclear whether quantification of visceral fat provides more accurate predictions of abdominal wound healing complications than BMI...
March 28, 2018: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29655637/analysis-of-human-blood-plasma-cell-free-dna-fragment-size-distribution-using-evagreen-chemistry-based-droplet-digital-pcr-assays
#11
M Rohan Fernando, Chao Jiang, Gary D Krzyzanowski, Wayne L Ryan
BACKGROUND: Plasma cell-free DNA (cfDNA) fragment size distribution provides important information required for diagnostic assay development. We have developed and optimized droplet digital PCR (ddPCR) assays that quantify short and long DNA fragments. These assays were used to analyze plasma cfDNA fragment size distribution in human blood. METHODS: Assays were designed to amplify 76,135, 490 and 905 base pair fragments of human β-actin gene. These assays were used for fragment size analysis of plasma cell-free, exosome and apoptotic body DNA obtained from normal and pregnant donors...
April 12, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29655567/acute-coronary-syndrome-relationship-between-genetic-variants-and-timi-risk
#12
Viviane do Carmo Vasconcelos de Carvalho, Lílian Caroliny Amorim Silva, Romário Martins Araújo, Fábia Carla da Silva Soares, Maria José Ribeiro Bezerra, Sávio Augusto Vieira de Oliveira, Alex José de Melo Silva, Sérgio Tavares Montenegro, Roberto Pereira Werkhauser, Carlos Gustavo Régis da Silva, Adriana Vieira Gomes, Clarice Neuenschwander Lins de Morais, Silvia Maria Lucena Montenegro
Acute Coronary Syndrome (ACS) is a multifactorial disease, including the genetic factor, caused by coronary artery obstruction by atheroma. Some genetic variants have been described as risk factors for this disease. Its early diagnosis and stratification of risk of death by Thrombolysis in Myocardial Infarction (TIMI) are important. Therefore, we evaluated variants in the IL6R (c950-1722C>T), TNFa (c.-488G>A), LEPR (c.2673+1118C>T) and IL1b (c.-598T>C) genes in relation to TIMI risk, cytokine serum levels, and risk factors for ACS...
April 11, 2018: Cytokine
https://www.readbyqxmd.com/read/29653454/how-does-autologous-breast-reconstruction-impact-downtime
#13
Giovanni Zoccali, Daniel Simon Rais, Jian Farhadi
BACKGROUND:  Although autologous breast reconstruction is technically quite demanding, it offers the best outcomes in terms of durable results, patient perceptions, and postoperative pain. Many studies have focused on clinical outcomes and technical aspects of such procedures, but few have addressed the impact of various flaps on patient recovery times. This particular investigation entailed an assessment of commonly used flaps, examining the periods of time required to resume daily activities...
April 13, 2018: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/29653426/evaluation-of-maximum-potential-gene-flow-from-herbicide-resistant-brassica-napus-to-its-male-sterile-relatives-under-open-and-wind-pollination-conditions
#14
Chuan-Jie Zhang, Min-Jung Yook, Hae-Rim Park, Soo-Hyun Lim, Jin-Won Kim, Jong-Seok Song, Gyoungju Nah, Hae-Ryong Song, Beom-Ho Jo, Kyung Hee Roh, Suhyoung Park, Young-Seok Jang, Ill-Sup Noua, Do-Soon Kim
Pollen-mediated gene flow (PMGF) from genetically modified (GM) Brassica napus to its wild relatives by wind and insects is a major ecological concern in agricultural ecosystems. This study conducted is to estimate maximum potential gene flow and differentiate between wind- and bee-mediated gene flows from herbicide resistant (HR) B. napus to its closely-related male sterile (MS) relatives, B. napus, B. juncea and Raphanus sativus. Various markers, including pods formation in MS plants, herbicide resistance, and SSR markers, were used to identify the hybrids...
April 10, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29653247/somatosensory-changes-at-forearm-donor-sites-following-three-different-surgical-flap-techniques
#15
Fang Wang, Xu Ding, Jinglu Zhang, Xiaomeng Song, Yunong Wu, Peter Svensson, Kelun Wang
BACKGROUND: The aim of this study was to investigate the somatosensory changes at the forearm donor region after using different types of modified flap surgical techniques. METHODS: Thirty-one patients, who underwent oral and maxillofacial reconstructive surgery involving the use of a traditional radial forearm flap (TRFF) or two modified radial forearm flap techniques (MRFF-I; MRFF-II), participated in the study. Cold detection threshold (CDT), warm detection threshold (WDT), cold pain threshold (CPT), heat pain threshold (HPT), pressure pain threshold (PPT), mechanical detection threshold (MDT), and mechanical pain threshold (MPT) were assessed at four sites of the forearms corresponding to the middle of the vascular pedicle (VP) area, the middle of the forearm flap area, and the corresponding contralateral sites (cVP and cFF) at about 5...
April 10, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29653206/late-effects-screening-guidelines-after-hematopoietic-cell-transplantation-hct-for-hemoglobinopathy-consensus-statement-from-the-second-pediatric-blood-and-marrow-transplant-consortium-international-conference-on-late-effects-after-pediatric-hct
#16
Shalini Shenoy, Javid Gaziev, Emanuele Angelucci, Allison King, Monica Bhatia, Angela Smith, Dorine Bresters, Anne E Haight, Christine N Duncan, Josu de la Fuente, Andrew C Dietz, K Scott Baker, Michael A Pulsipher, Mark C Walters
Allogeneic hematopoietic cell transplantation (HCT) can halt organ damage and eliminate symptoms in hemoglobin disorders, including sickle cell disease (SCD) and thalassemia major (TM). Managing the residual manifestations of pre-HCT disease complications and the long-term effects of HCT requires systematic monitoring, follow-up, and intervention when indicated. Late complications vary with age and disease status at HCT, and with transplant variables such as preparative regimen, donor source and compatibility, and immune reconstitution...
April 10, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29653141/dual-mechanism-of-type-vii-collagen-transfer-by-bone-marrow-mesenchymal-stem-cell-extracellular-vesicles-to-recessive-dystrophic-epidermolysis-bullosa-fibroblasts
#17
Jeffrey McBride, Luis Rodriguez-Menocal, Ambar Candanedo, Wellington Guzman, Marta Garcia-Contreras, Evangelos Badiavas
Recessive dystrophic epidermolysis bullosa (RDEB) is a severe blistering disease resulting from a lack of type VII collagen production. Recent clinical trials have shown efficacy of bone marrow-derived mesenchymal stem cells (BM-MSCs) in the treatment of epidermolysis bullosa, including improved basement membrane restructuring and cutaneous wound healing. The mechanism as to how type VII collagen is transferred from donor stem cell to recipient RDEB cells has not been defined. Here, we submit the model that BM-MSC-derived extracellular vesicles serve at least two roles: 1) to help transport type VII collagen within the extracellular space; and 2) to feed RDEB fibroblasts with messenger RNA that codes for type VII collagen, resulting in COL7A1 translation and synthesis of type VII collagen alpha chain proteins by RDEB fibroblasts...
April 10, 2018: Biochimie
https://www.readbyqxmd.com/read/29652917/prevalent-hepatitis-b-surface-antigen-among-first-time-blood-donors-in-gabon
#18
Jean Marie Eko Mba, Cyrille Bisseye, Jophrette Mireille Ntsame Ndong, Landry Erik Mombo, Calixte Bengone, Guy Mouelet Migolet, Bertrand M'batchi, Heidi E Kosiorek, Richard J Butterfield, Lewis R Roberts, Mitesh J Borad, Bolni Marius Nagalo
Despite chronic Hepatitis B virus (HBV) infection being the main cause of younger-onset complex liver disease including cirrhosis and hepatocellular carcinoma (HCC) in Africa, very little is known regarding the seroprevalence of HBV in the Gabonese general population. This investigation aimed to provide strong epidemiological data and risk factors associated with HBV infection in first-time blood donors representative of the urban adult population. The screening of HBsAg was carried out using 4th generation ELISA kits...
2018: PloS One
https://www.readbyqxmd.com/read/29652887/ethnicity-matching-and-outcomes-after-kidney-transplantation-in-the-united-kingdom
#19
Bhavini Pisavadia, Adam Arshad, Imogen Chappelow, Peter Nightingale, Benjamin Anderson, Jay Nath, Adnan Sharif
BACKGROUND: Kidneys from non-white donors have inferior outcomes, but it is unclear if ethnicity matching between donors and recipients achieves better post kidney transplant outcomes. METHODS: We undertook a retrospective, population cohort study utilising UK Transplant Registry data. The cohort comprised adult, kidney-alone, transplant recipients receiving their first kidney transplant between 2003-2015, with data censored at 1st October 2016. We included 27,970 recipients stratified into white (n = 23,215), black (n = 1,679) and south Asian (n = 3,076) ethnicity, with median post-transplant follow-up of 1,676 days (IQR 716-2,869 days)...
2018: PloS One
https://www.readbyqxmd.com/read/29652627/visualizing-intra-population-hematopoietic-cell-heterogeneity-with-self-organizing-maps-of-sims-data
#20
Vahid Mirshafiee, Brendan A C Harley, Mary L Kraft
Characterization of the heterogeneity within stem cell populations, which affects their differentiation potential, is necessary for the design of artificial cultures for stem cell expansion. In this study, we assessed whether self-organizing maps (SOMs) of single cell time-of-flight secondary ion mass spectrometry (TOF-SIMS) data provide insight into the spectral, and thus the related functional heterogeneity between and within three hematopoietic cell populations. SOMs were created of TOF-SIMS data from individual hematopoietic stem and progenitor cells (HSPCs), lineage-committed common lymphoid progenitors (CLPs), and fully differentiated B cells that had been isolated from murine bone marrow via conventional flow cytometry...
March 16, 2018: Tissue Engineering. Part C, Methods
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