keyword
MENU ▼
Read by QxMD icon Read
search

donors

keyword
https://www.readbyqxmd.com/read/29909506/the-influence-of-in-vitro-pectin-fermentation-on-the-human-fecal-microbiome
#1
So-Jung Bang, Gayoung Kim, Mi Young Lim, Eun-Ji Song, Dong-Hyun Jung, Jun-Seok Kum, Young-Do Nam, Cheon-Seok Park, Dong-Ho Seo
Pectin is a complex dietary fiber and a prebiotic. To investigate pectin-induced changes in the gut microbiome and their effects on the short chain fatty acids (SCFAs) production, we performed in vitro pectin fermentation using the feces of three Korean donors. The pectin degradations in all three donors were observed. While the donors displayed differences in baseline gut microbiota composition, commonly increased bacteria after pectin fermentation included Lachnospira, Dorea, Clostridium, and Sutterella. Regarding SCFAs, acetate levels rapidly increased with incubation with pectin, and butyrate levels also increased after 6 h of incubation...
June 16, 2018: AMB Express
https://www.readbyqxmd.com/read/29909389/delayed-presentation-of-iatrogenic-splenic-injury-21-days-after-laparoscopic-donor-left-nephrectomy
#2
Kelvin Yafan Wang, Omar Abbassi, Ali Warsi
We report the case of a 46-year-old woman who had presented with left-sided abdominal pain 21 days after undergoing a left-sided laparoscopic nephrectomy for donation. Initial haemoglobin and haematocrit levels were within normal range, and vital signs on admission were unremarkable. Significant intra-abdominal pathology was not suspected; however, inpatient CT scan of the abdomen showed a posterolateral subcapsular splenic haematoma with free abdominal fluid. Initial trial of conservative management was not successful as the patient became hypotensive on the third day of admission with a sudden decrease in haemoglobin and haematocrit...
June 15, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29909325/a-novel-microfluidic-system-enables-visualization-and-analysis-of-antibiotic-resistance-gene-transfer-to-activated-sludge-bacteria-in-biofilm
#3
Yong Qiu, Jing Zhang, Bing Li, Xianghua Wen, Peng Liang, Xia Huang
Antibiotic resistance genes (ARGs) in environment have become a growing public concern, due to their potential to be obtained by pathogens and their duplication along cell division. Horizontal gene transfer (HGT) was reported to be responsible for ARGs dissemination in microbes, but the HGT feature in environmental biofilm was still unclear due to insufficient assay tools. To address this challenge, we applied a novel microfluidic system to cultivate thin biofilm by continuous supply of nutrients and close contact between cells...
June 14, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29909152/early-fever-after-haploidentical-bmt-correlates-with-class-ii-hla-mismatching-and-myeloablation-but-not-outcomes
#4
Shannon R McCurdy, Stephen T Muth, Hua-Ling Tsai, Heather J Symons, Carol Ann Huff, William H Matsui, Ivan Borrello, Douglas E Gladstone, Lode J Swinnen, Kenneth R Cooke, Robert A Brodksy, Javier Bolaños-Meade, Richard F Ambinder, Ravi Varadhan, Leo Luznik, Rick J Jones, Maria P Bettinotti, Ephraim J Fuchs
Non-infectious fevers are common early after T-cell replete HLA-haploidentical (haplo) peripheral blood transplants and have been associated with cytokine release syndrome and overall mortality. However, less is known regarding the incidence and associations of early fever after bone marrow transplantation (BMT) with post-transplant cyclophosphamide (PTCy). We hypothesized that early fever would be associated with myeloablative conditioning (MAC), because of its relative increase in tissue damage augmenting antigen-presentation, and Class II HLA-mismatching, due recognition of antigen-presenting cells by CD4+ T-cells...
June 15, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29909151/hematogones-predict-better-outcome-in-allogeneic-hematopoietic-stem-cell-transplantation-irrespective-of-graft-sources
#5
Takashi Ishio, Junichi Sugita, Takahiro Tateno, Daisuke Hidaka, Eiko Hayase, Souichi Shiratori, Kohei Okada, Hideki Goto, Masahiro Onozawa, Masao Nakagawa, Daigo Hashimoto, Kaoru Kahata, Katsuya Fujimoto, Tomoyuki Endo, Takeshi Kondo, Takanori Teshima
Benign precursors of B lymphocytes, termed hematogones, are observed in the regenerative state of hematopoiesis following chemotherapy or allogeneic hematopoietic stem cell transplantation (allo-HSCT). Previous studies have demonstrated that expansion of hematogones correlates with better clinical outcomes after allo-HSCT. We retrospectively analyzed the association between hematogones and clinical outcomes in 309 consecutive patients undergone allo-HSCT, which was the largest population-based cohort reported so far...
June 14, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29909116/altered-microrna-regulation-of-short-chain-fatty-acid-receptors-in-the-hypertensive-kidney-is-normalized-with-hydrogen-sulfide-supplementation
#6
Gregory J Weber, Jaleyea Foster, Sathnur B Pushpakumar, Utpal Sen
Hypertension affects nearly one third of the adult US population and is a significant risk factor for chronic kidney disease (CKD). An expanding body of recent studies indicates that gut microbiome has crucial roles in regulating physiological processes through, among other mechanisms, one mode of short chain fatty acids (SCFA) and their target receptors. In addition, these SCFA receptors are potential targets of regulation by host miRNAs, however, the mechanisms through which this occurs is not clearly defined...
June 14, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29909081/-13-c-%C3%A2-1-h-transfer-of-light-induced-hyperpolarization-allows-for-selective-detection-of-protons-in-frozen-photosynthetic-reaction-center
#7
Pavlo Bielytskyi, Daniel Gräsing, Kaustubh R Mote, Karthick Babu Sai Sankar Gupta, Shimon Vega, P K Madhu, A Alia, Jörg Matysik
In the present study, we exploit the light-induced hyperpolarization occurring on 13 C nuclei due to the solid-state photochemically induced dynamic nuclear polarization (photo-CIDNP) effect to boost the NMR signal intensity of selected protons via inverse cross-polarization. Such hyperpolarization transfer is implemented into 1 H-detected two-dimensional 13 C-1 H correlation magic-angle-spinning (MAS) NMR experiment to study protons in frozen photosynthetic reaction centers (RCs). As a first trial, the performance of such an experiment is tested on selectively 13 C labeled RCs from the purple bacteria of Rhodobacter sphaeroides...
June 8, 2018: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/29909020/diet-modifies-colonic-microbiota-and-cd4-t-cell-repertoire-to-induce-flares-of-colitis-in-mice-with-myeloid-cell-expression-of-interleukin-23
#8
Lili Chen, Zhengxiang He, Alina Cornelia Iuga, Sebastião N Martins Filho, Jeremiah J Faith, Jose C Clemente, Madhura Deshpande, Anitha Jayaprakash, Jean-Frederic Colombel, Juan J Lafaille, Ravi Sachidanandam, Glaucia C Furtado, Sergio A Lira
BACKGROUND & AIMS: Several studies have shown that signaling via the interleukin 23 (IL23) receptor is required for development of colitis. We studied the roles of IL23, dietary factors, alterations to the microbiota, and T cells in development and progression of colitis in mice. METHODS: All mice were maintained on lab diet 5053, unless otherwise noted. We generated mice that express IL23 in CX3CR1-positive myeloid cells (R23FR mice) upon cyclic administration of tamoxifen dissolved in diet 2019...
June 14, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29908901/neonatal-rbc-transfusions-do-benefits-outweigh-risks
#9
REVIEW
Iman F Iskander, Khaled M Salama, Rasha M Gamaleldin, Jerard Seghatchian
Preterm neonates represent one of the most transfused categories of patients. Their target hematocrits, however, are mainly based on expert opinion. The risk of transfusions are very high in the smallest preterm baby with a weak immune response, immature antioxidant ability, fragile germinal matrix and impaired cerebral autoregulation, yet red cell transfusions remain the only life saving measure in the baby with symptomatic anemia. Minimizing phlebotomy losses, following a restrictive transfusion policy and using screened, leukocyte depleted, irradiated, single donor blood remain the best means of avoiding the possible risks while maximizing the benefits of red cell transfusions in the preterm newborn...
May 9, 2018: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29908883/ex-vivo-experimental-validation-of-biomechanically-corrected-intraocular-pressure-measurements-on-human-eyes-using-the-corvis-st
#10
Ashkan Eliasy, Kai-Jung Chen, Riccardo Vinciguerra, Osama Maklad, Paolo Vinciguerra, Renato Ambrósio, Cynthia J Roberts, Ahmed Elsheikh
The purpose of this study was to assess the validity of the Corvis ST (Oculus; Wetzlar, Germany) biomechanical correction algorithm (bIOP) in determining intraocular pressure (IOP) using experiments on ex-vivo human eyes. Five ex-vivo human ocular globes (age 69 ± 3 years) were obtained and tested within 3-5 days post mortem. Using a custom-built inflation rig, the internal pressure of the eyes was controlled mechanically and measured using the CorVis ST (CVS-IOP). The CVS-IOP measurements were then corrected to produce bIOP, which was developed for being less affected by variations in corneal biomechanical parameters, including tissue thickness and material properties...
June 14, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29908844/tissue-associated-self-antigens-containing-exosomes-role-in-allograft-rejection
#11
Monal Sharma, Ranjithkumar Ravichandran, Sandhya Bansal, Ross M Bremner, Michael A Smith, T Mohanakumar
Exosomes are extracellular vesicles that express self-antigens (SAgs) and donor human leukocyte antigens. Tissue-specific exosomes can be detected in the circulation following lung, heart, kidney and islet cell transplantations. We collected serum samples from patients who had undergone lung (n=30), heart (n=8), or kidney (n=15) transplantations to isolate circulating exosomes. Exosome purity was analyzed by Western blot, using CD9 exosome-specific markers. Tissue-associated lung SAgs, collagen V (Col-V) and K-alpha 1 tubulin (Kα1T), heart SAgs, myosin and vimentin, and kidney SAgs, fibronectin and collagen IV (Col-IV), were identified using western blot...
June 14, 2018: Human Immunology
https://www.readbyqxmd.com/read/29908629/the-pedicled-anterolateral-thigh-phalloplasty
#12
REVIEW
Kyle Y Xu, Andrew J Watt
The anterolateral thigh (ALT) flap is a viable and reliable option for phalloplasty. The primary advantages of the ALT flap remain an inconspicuous donor site and flexibility in phallus length. The disadvantages of the ALT flap are a higher incidence of both flap and urethral complications compared with a radial forearm phalloplasty. Although the ALT phalloplasty can achieve the primary goals of standing micturition, penetrative intercourse, and an aesthetic phallus, multiple stages and revisions are often necessary...
July 2018: Clinics in Plastic Surgery
https://www.readbyqxmd.com/read/29908627/introduction-to-phalloplasty
#13
REVIEW
Loren S Schechter, Bauback Safa
Phalloplasty represents the most complete genitoperineal transformation. Because it requires complex, staged procedures as well as the use of tissue from remote sites, patients must be well informed as to the nature of surgery. Surgical techniques for phalloplasty continue to evolve. Although many surgeons prefer the radial forearm free flap technique, a visible flap donor site makes this procedure less desirable for some patients. Other surgical options are available and include the anterolateral thigh flap, sometimes in conjunction with secondary flaps, and the musculocutaneous latissimus dorsi flap...
July 2018: Clinics in Plastic Surgery
https://www.readbyqxmd.com/read/29908465/anoxic-nitrogen-cycling-in-a-hydrocarbon-and-ammonium-contaminated-aquifer
#14
Naomi S Wells, Uwe Kappelmeyer, Kay Knöller
Nitrogen fate and transport through contaminated groundwater systems, where N is both ubiquitous and commonly limits pollutant attenuation, must be re-evaluated given evidence for new potential microbial N pathways. We addressed this by measuring the isotopic composition of dissolved inorganic N (DIN = NH4 + , NO2 - , and NO3 - ) and N functional gene abundances (amoA, nirK, nirS, hszA) from 20 to 38 wells across an NH4 + , hydrocarbon, and SO4 2- contaminated aquifer. In-situ N attenuation was confirmed on three sampling dates (0, +6, +12 months) by the decreased [DIN] (4300 - 40 μM) and increased δ15 N-DIN (5‰-33‰) over the flow path...
June 13, 2018: Water Research
https://www.readbyqxmd.com/read/29908414/synthesis-and-photophysical-properties-of-deuteration-of-pirfenidone
#15
Qiuju Yin, Yujie Chen, Meng Zhou, Xiangsheng Jiang, Junjun Wu, Yang Sun
In order to improve the metabolism of pirfenidone (5-methyl-1-phenylpyridin-2-one, PFD), the methyl-deuterated version of pirfenidone via the substitution of hydrogen (H) at C-5 by its isotope deuterium (D, 5D-PFD) was synthesized and its photophysical properties were investigated. The negative solvatochrom was observed in absorption and fluorescence spectra with increasing solvent polarity, which implied that intermolecular charge transfer (ICT) involved n → π* transition for both of PFD and 5D-PFD...
June 7, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29908316/the-clinical-significance-of-epitope-mismatch-load-in-kidney-transplantation-a-multicentre-study
#16
Liesbeth Daniëls, Maarten Naesens, Jean-Louis Bosmans, Daniel Abramowicz, Evi Nagler, Steven Van Laecke, Patrick Peeters, Dirk Kuypers, Marie-Paule Emonds
Since the advent of kidney transplantation a key strategy for maximising graft survival by avoiding allorecognition has been to minimise HLA mismatching between donor and recipient. As HLA antibodies are now recognised as being specific for epitopes and donor-recipient HLA mismatch at the amino acid level can now be determined, HLA epitope mismatch load could be a better predictor for dnDSA development than classical HLA antigen mismatch calculation. This hypothesis has been investigated by other studies and the aim of our multicentre study was to confirm this observation in our population...
June 13, 2018: Transplant Immunology
https://www.readbyqxmd.com/read/29908298/hydrogen-sulfide-epigenetically-mitigates-bone-loss-through-opg-rankl-regulation-during-hyperhomocysteinemia-in-mice
#17
Jyotirmaya Behera, Akash K George, Michael J Voor, Suresh C Tyagi, Neetu Tyagi
Hydrogen sulfide (H2 S) is a novel gasotransmitter produced endogenously in mammalian cells, which works by mediating diverse physiological functions. An imbalance in H2 S metabolism is associated with defective bone homeostasis. However, it is unknown whether H2 S plays any epigenetic role in bone loss induced by hyperhomocysteinemia (HHcy). We demonstrate that diet-induced HHcy, a mouse model of metabolite induced osteoporosis, alters homocysteine metabolism by decreasing plasma levels of H2 S. Treatment with NaHS (H2 S donor), normalizes the plasma level of H2 S and further alleviates HHcy induced trabecular bone loss and mechanical strength...
June 13, 2018: Bone
https://www.readbyqxmd.com/read/29908296/sonographically-guided-plantaris-tendon-release-a-cadaveric-validation-study
#18
Jay Smith, Håkan Alfredson, Lorenzo Masci, Jacob L Sellon, Charonn D Woods
BACKGROUND: The plantaris tendon (PT) has been implicated in the pathogenesis of symptoms in a subset of patients with Achilles region pain syndromes and has been traditionally managed via open surgical resection. Although the PT can be visualized on ultrasound, a minimally invasive technique for sonographically guided PT release has not been formally described. OBJECTIVE: To validate a technique to perform sonographically guided PT release in an unembalmed cadaveric model...
June 13, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29908231/haploidentical-bone-marrow-transplantation-with-post-transplant-cyclophosphamide-bendamustine-in-pediatric-and-young-adult-patients-with-hematologic-malignancies
#19
Emmanuel Katsanis, Lauren N Sapp, Nicole Varner, Shannon Koza, Baldassarre Stea, Yi Zeng
More than half of patients undergoing hematopoietic cell transplantation at our institution are ethnic or racial minorities, making the search for matched unrelated donors more challenging. Since the introduction of haploidentical bone marrow transplant (haplo-BMT) into our pediatric BMT program in 2015, 69.2% of the recipients have been minorities. Herein, we describe our experience with the first thirteen pediatric and young adult patients with hematologic malignancies who have undergone T-cell replete haplo-BMT following myeloablative conditioning (MAC) at our institution...
June 13, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29908158/amplified-fret-based-ca15-3-immunosensor-using-antibody-functionalized-luminescent-carbon-dots-and-aunps-dendrimer-aptamer-as-donor-acceptor
#20
Somayeh Mohammadi, Abdollah Salimi, Somayeh Hamde Qaddareh
We proposed an amplified FRET immunosensing for detection of CA15-3 tumor marker by highly biospecific interactions between CA 15-3 antigen and the corresponding antibody and aptamer. In this sandwich type immunoassay, CA15-3 antibody-functionalized carbon dots and AuNPs labeled PAMAM-Dendrimer/aptamer were used as donor/acceptor, respectively. When CA 15-3 Ag was added to homogenous immunoassay, the strong complex interaction between CA15-3 Ab-CA15-3 Ag- aptamer caused in more coming closer carbon dot and AuNPs and more decreasing fluorescence signal...
June 13, 2018: Analytical Biochemistry
keyword
keyword
40994
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"