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https://www.readbyqxmd.com/read/27904723/why-cannot-suction-drains-prevent-postoperative-spinal-epidural-hematoma
#1
Dong Ki Ahn, Won Shik Shin, Jin Woo Kim, Seong Min Yi
BACKGROUND: Postoperative spinal epidural hematoma (POSEH) is different from spontaneous or post-spinal procedure hematoma because of the application of suction drains. However, it appeared that suction drains were not effective for prevention of POSEH in previous studies. The purpose of this study was to test our hypothesis that POSEH can be caused by hypercoagulability. METHODS: This was an experimental study. One hundred fifty milliliters of blood was donated from each of the 12 consecutive patients who underwent spine surgery and infused into 3 saline bags of 50 mL each...
December 2016: Clinics in Orthopedic Surgery
https://www.readbyqxmd.com/read/27904569/thank-you-for-saving-my-life-blood-donation-matters
#2
Saurabh R Shrivastava, Prateek S Shrivastava, Jegadeesh Ramasamy
No abstract text is available yet for this article.
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27903355/-factors-associated-with-commercial-sexual-behavior-among-men-who-have-sex-with-men-in-shenzhen-china-in-2011-2015
#3
Y M Cai, Y J Song, H Liu, F C Hong
Objective: To investigate the status and factors associated with commercial sexual behavior among men who have sex with men (MSM) in Shenzhen. Methods: A convenience sampling method was used to recruit MSM in Shenzhen from 2011 to 2015. Questionnaire-based interviews were conducted on a one-on-one basis. Data were collected, including socio-demographic information, HIV testing history, history of blood donation and drug abuse in the last 2 years, self-reported sexual orientation, role in homosexual behavior, and experience serving as a male sex worker and/or as a client of male sex workers...
November 6, 2016: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/27902880/monoamine-oxidase-inhibitory-activity-methyl-versus-chlorochalcone-derivatives
#4
Bijo Mathew, Gülberk Uçar, Githa Elizabeth Mathew, Sincy Mathew, Praseedha Kalatharakkal Purapurath, Fasil Moolayil, Smrithy Mohan, Sheeba Varghese Gupta
Numerous studies have shown that chalcones are promising scaffolds for the development of new monoamine oxidase-B (MAO-B) inhibitors. As a continuation of our ongoing research into the development of reversible human MAO-B (hMAO-B) inhibitors, two series of twenty chalcones containing electron-donating and electron-withdrawing substituents were synthesized. All compounds were found to be competitive, selective, and reversible inhibitors of hMAO-B except (2E)-1-(4-methylphenyl)-3-(4-nitrophenyl)prop-2-en-1-one (P7) and (2E)-1-(4-chlorophenyl)-3-(4-nitrophenyl)prop-2-en-1-one (P17), which were found to be selective inhibitors of hMAO-A...
November 30, 2016: ChemMedChem
https://www.readbyqxmd.com/read/27900795/deferral-for-low-hemoglobin-is-not-associated-with-increased-risk-of-infection-in-danish-blood-donors
#5
Sebastian R Kotzé, Ole B Pedersen, Mikkel S Petersen, Erik Sørensen, Khoa Manh Dinh, Kathrine Agergård Kaspersen, Andreas S Rigas, Henrik Hjalgrim, Klaus Rostgaard, Gustaf Edgren, Henrik Ullum, Christian Erikstrup
BACKGROUND: Low hemoglobin (Hb) is associated with poor general health and adverse outcomes in a wide range of diseases. However, a link between Hb levels and the risk of infection among healthy individuals has yet to be investigated. STUDY DESIGN AND METHODS: Using data from the Scandinavian Donations and Transfusions database, 497,390 donors were followed after 5,458,499 donations in health registers. With 1,339,362 person-years of follow-up, Andersen-Gill Cox regression was used to study the association of Hb levels below deferral thresholds, very low Hb levels (in the lowest 0...
November 29, 2016: Transfusion
https://www.readbyqxmd.com/read/27900758/99mtc-hmpao-perfusion-spect-ct-in-the-diagnosis-of-brain-death
#6
Thorsten Derlin, Desiree Weiberg
This report describes a case of brain death (BD) evaluated by 99mTc-hexamethylpropylene amine oxime (HMPAO) single photon emission tomography/computed tomography (SPECT/CT). A 16-year-old boy with a history of rapid unexpected brain herniation due to pilocytic astrocytoma underwent 99mTc-HMPAO SPECT/CT for evaluation of brain death in the context of organ donation. Flow images demonstrated lack of blood flow to the brain, and delayed images showed absence of demonstrable radionuclide activity within the brain...
2016: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/27891624/quarantine-versus-pathogen-reduced-plasma-coagulation-factor-content-and-rotational-thromboelastometry-coagulation
#7
Oliver M Theusinger, David Goslings, Jan-Dirk Studt, Brigitte Brand-Staufer, Burkhardt Seifert, Donat R Spahn, Beat M Frey
BACKGROUND: Different types of fresh-frozen plasma (FFP) exist, and the concentrations of plasma proteins vary between individuals and blood groups. Furthermore, processing may also influence the content. Quarantine-stored plasma (qFFP) and plasma that was pathogen-reduced using blood-safety (Intercept) technology (piFFP) were analyzed regarding procoagulant and anticoagulant hemostasis proteins, including endogenous thrombin (thrombin-generation) potential (ETP). MATERIALS AND METHODS: Thirty-five samples of each type of FFP were analyzed using only male Blood Group O donors...
November 27, 2016: Transfusion
https://www.readbyqxmd.com/read/27891345/voluntary-blood-donation-among-students-a-cross-sectional-study-on-knowledge-and-practice-vs-attitude
#8
Babita Raghuwanshi, Nand K Pehlajani, Mithilesh K Sinha
INTRODUCTION: The factors influencing blood donation decisions are varied and complex and one's attitude can influence this decision. AIM: To find the factors affecting the knowledge and practice of blood donation among college students and their attitude towards the same. MATERIALS AND METHODS: This cross-sectional study was conducted among 399 college going students using convenience sampling from medical, nursing and engineering colleges in Bhubaneswar city, where blood donation camps were to be held...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27891232/prevalence-of-transfusion-transmissible-infections-in-blood-donors-of-pakistan
#9
Aisha Arshad, Munira Borhany, Nida Anwar, Imran Naseer, Rehan Ansari, Samson Boota, Naveena Fatima, Mustansir Zaidi, Tahir Shamsi
BACKGROUND: Transfusion-transmitted infections threaten the safety of patients requiring blood transfusion, which in turn imposes serious challenges for the availability of safe blood products that are still affordable in health care systems with limited resources. The aim of the study was to determine the prevalence of transfusion-transmitted infections in blood donors and to evaluate the demographic characteristics of reactive and non-reactive blood donors. METHODS: A prospective cohort study was conducted at our institute in Karachi, Pakistan...
2016: BMC Hematology
https://www.readbyqxmd.com/read/27887885/the-watching-eyes-phenomenon-and-blood-donation-does-exposure-to-pictures-of-eyes-increase-blood-donation-by-young-adults
#10
Cécile Sénémeaud, Camille Sanrey, Nathalie Callé, Candice Plainfossé, Alexandra Belhaire, Patrice Georget
This study examined the effectiveness of exposure to a "watching-eyes image" in increasing blood donation rates among young people, a segment of the population that is particularly underrepresented among blood donors. Participants were 454 first-year university students, each of who was given a blood-donation flyer at the beginning of a lecture. Participants were randomly assigned to one of two conditions depending on whether the flyer they received bore a picture of eyes (experimental condition) or a neutral picture (control condition)...
November 14, 2016: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/27878046/back-to-back-comparison-of-mini-open-vs-laparoscopic-technique-for-living-kidney-donation
#11
Christie Rampersad, Premal Patel, Joshua Koulack, Thomas McGregor
INTRODUCTION: Laparoscopic living donor nephrectomy is the standard of care at high-volume renal transplant centres, with benefits over the open approach well-documented in the literature. Herein, we present a retrospective analysis of our single-institution donor nephrectomy series comparing the mini-open donor nephrectomy (mini-ODN) to the laparoscopic donor nephrectomy (LDN) with regards to operative, donor, and recipient outcomes. METHODS: From 2007-2011, there were 89 cases of mini-ODN, at which point our centre transitioned to LDN; 94 cases were performed from 2011-2014...
August 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/27873242/effect-of-repeated-whole-blood-donations-on-aerobic-capacity-and-hemoglobin-mass-in-moderately-trained-male-subjects-a-randomized-controlled-trial
#12
Julie Meurrens, Thomas Steiner, Jonathan Ponette, Hans Antonius Janssen, Monique Ramaekers, Jon Peter Wehrlin, Philippe Vandekerckhove, Louise Deldicque
BACKGROUND: The aims of the present study were to investigate the impact of three whole blood donations on endurance capacity and hematological parameters and to determine the duration to fully recover initial endurance capacity and hematological parameters after each donation. METHODS: Twenty-four moderately trained subjects were randomly divided in a donation (n = 16) and a placebo (n = 8) group. Each of the three donations was interspersed by 3 months, and the recovery of endurance capacity and hematological parameters was monitored up to 1 month after donation...
December 2016: Sports Medicine—Open
https://www.readbyqxmd.com/read/27873139/when-marcel-mauss-s-essai-sur-le-don-becomes-the-gift-variations-on-the-theme-of-solidarity
#13
Simone Bateman
Since the early 1970s, Marcel Mauss's Essai sur le Don (1923), translated into English as The Gift in 1954, has been a standard reference in the social science and bioethical literature on the use of human body parts and substances for medical and research purposes. At that time, three social scientists-political scientist Richard Titmuss in the United Kingdom and sociologist Renée C. Fox working with historian Judith Swazey in the United States-had the idea of using this concept to highlight the fundamental structure of the biomedical practices they were studying, respectively, blood donation, and hemodialysis and organ transplantation...
November 21, 2016: Theoretical Medicine and Bioethics
https://www.readbyqxmd.com/read/27871571/spine-tumor-resection-among-patients-who-refuse-blood-product-transfusion-a-retrospective-case-series
#14
Alexandra E Kisilevsky, Liam Stobart, Kristine Roland, Alana M Flexman
STUDY OBJECTIVE: To describe the perioperative blood conservation strategies and postoperative outcomes in patients who undergo complex spinal surgery for tumor resection and who also refuse blood product transfusion. DESIGN: A retrospective case series. SETTING: A single-center, tertiary care and academic teaching hospital in Canada. PATIENTS: All adult patients undergoing elective major spine tumor resection and refusing blood product transfusion who were referred to our institutional Blood Utilization Program between June 1, 2004, and May 9, 2014...
December 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27870058/iron-deficiency-and-thrombocytosis
#15
A Holbro, T Volken, A Buser, J P Sigle, J P Halter, J R Passweg, A Tichelli, L Infanti
According to many textbooks, iron deficiency (ID) is associated with reactive thrombocytosis. In this study, we aimed to investigate the correlation between serum ferritin levels and platelet counts in a large cohort of healthy blood donors. We included all whole blood and apheresis donors aged 18 years or older with at least one ferritin measurement and one platelet count performed at the same visit between 1996 and 2014. A total of 130 345 blood counts and ferritin measurements obtained from 22 046 healthy donors were analysed...
November 21, 2016: Vox Sanguinis
https://www.readbyqxmd.com/read/27864712/associations-between-serum-lipids-and-breast-cancer-incidence-and-survival-in-the-e3n-prospective-cohort-study
#16
Mathilde His, Laureen Dartois, Guy Fagherazzi, Anne Boutten, Thierry Dupré, Sylvie Mesrine, Marie-Christine Boutron-Ruault, Françoise Clavel-Chapelon, Laure Dossus
PURPOSE: Several mechanistic studies support a role of cholesterol or its metabolites in breast cancer etiology, but associations have been inconsistent in epidemiological studies. In observational studies, possible reverse causation must be accounted for using a prospective design. We investigated prospective associations between pre-diagnostic serum lipid concentrations [total cholesterol (TC), high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides], and both breast cancer risk and survival in the E3N cohort study...
November 18, 2016: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/27863321/cognitive-dysfunction-correlates-with-elevated-serum-s100b-concentration-in-drug-free-acutely-relapsed-patients-with-schizophrenia
#17
Song Chen, Li Tian, Nan Chen, Meihong Xiu, Zhiren Wang, Guigang Yang, Chuanyue Wang, Fude Yang, Yunlong Tan
S100B, a biomarker of glial dysfunction and blood-brain barrier (BBB) disruption, has been proposed to be involved in the pathophysiology of schizophrenia. In the present study, we aimed at exploring the association of serum S100B levels with cognitive deficits using MATRICS Consensus Cognitive Battery (MCCB) in schizophrenia, by excluding the impact of antipsychotics. Sixty-two unmedicated patients with schizophrenia during their acute phases were divided into a drug-naïve group (n=34) and a drug-free group (n=28)...
September 22, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27862705/screening-of-living-organ-donors-for-endemic-infections-understanding-the-challenges-and-benefits-of-enhanced-screening
#18
REVIEW
Amanda Rosen, Michael G Ison
Living organ donor candidates are screened for medical and psychosocial contraindications to donation. One important goal of this process is to prevent donor-derived infectious diseases transmissions. These transmissions are exceptionally rare, but have the potential to cause significant morbidity and mortality. The Organ Procurement and Transplantation Network now requires each recovery hospital to develop a protocol for evaluating living donors for tuberculosis and other geographically-defined endemic pathogens, including Trypanosoma cruzi (the causative pathogen of Chagas' disease), Strongyloides stercoralis, and West Nile Virus (WNV), in addition to universal screening for blood-borne pathogens...
November 14, 2016: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/27861957/improved-donor-safety-in-high-volume-apheresis-collections
#19
Ralph R Vassallo, Marjorie D Bravo, Hany Kamel
BACKGROUND: Separators use 1960s sex-based nomograms to estimate apheresis donor blood volume and to calculate the 15% maximum extracorporeal and collection volumes. As US body habitus changes, proportional overestimation of the maximum safe collection volume may become clinically significant with large-volume collections. We correlated 2 years of vasovagal reaction (VVR) data with 148,416 Trima apheresis procedure parameters to identify trends. STUDY DESIGN AND METHODS: Only platelet/plasma with or without red blood cell (RBC) procedures yielded collection volumes of at least 900 mL with no saline replacement...
November 10, 2016: Transfusion
https://www.readbyqxmd.com/read/27861290/pathophysiological-trends-during-withdrawal-of-life-support-implications-for-organ-donation-after-circulatory-death
#20
Arjun Iyer, Hong Chee Chew, Ling Gao, Jeanette Villanueva, Mark Hicks, Aoife Doyle, Gayathri Kumarasinghe, Andrew Jabbour, Paul Cassius Jansz, Michael P Feneley, Richard P Harvey, Robert M Graham, Kumud K Dhital, Peter S Macdonald
BACKGROUND: Donation after circulatory death (DCD) provides an alternative pathway to deceased organ transplantation. Although clinical DCD lung, liver, and kidney transplantation are well established, transplantation of hearts retrieved from DCD donors has reached clinical translation only recently. Progress has been limited by concern regarding the viability of DCD hearts. The aim of this study was to document the pathophysiological changes that occur in the heart and circulation during withdrawal of life (WLS) support...
December 2016: Transplantation
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