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https://www.readbyqxmd.com/read/27269942/double-blind-placebo-controlled-randomized-phase-iii-trial-evaluating-pertuzumab-combined-with-chemotherapy-for-low-tumor-human-epidermal-growth-factor-receptor-3-mrna-expressing-platinum-resistant-ovarian-cancer-penelope
#1
Christian Kurzeder, Isabel Bover, Frederik Marmé, Joern Rau, Patricia Pautier, Nicoletta Colombo, Domenica Lorusso, Petronella Ottevanger, Maria Bjurberg, Christian Marth, Pilar Barretina-Ginesta, Ignace Vergote, Anne Floquet, Josep M Del Campo, Sven Mahner, Lydie Bastière-Truchot, Nicolas Martin, Mikkel Z Oestergaard, Astrid Kiermaier, Carmen Schade-Brittinger, Sandra Polleis, Andreas du Bois, Antonio Gonzalez-Martin
PURPOSE: The AGO-OVAR 2.29/ENGOT-ov14/PENELOPE prospectively randomized phase III trial evaluated the addition of pertuzumab to chemotherapy in patients with platinum-resistant ovarian carcinoma with low tumor human epidermal growth factor receptor 3 (HER3) mRNA expression. We report the results of the primary efficacy analysis. PATIENTS AND METHODS: Eligible patients had ovarian carcinoma that progressed during or within 6 months of completing four or more platinum cycles, centrally tested low tumor HER3 mRNA expression (concentration ratio ≤ 2...
July 20, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/26556905/statement-by-the-kommission-ovar-of-the-ago-the-new-figo-and-who-classifications-of-ovarian-fallopian-tube-and-primary-peritoneal-cancer
#2
I Meinhold-Heerlein, C Fotopoulou, P Harter, C Kurzeder, A Mustea, P Wimberger, S Hauptmann, J Sehouli
More than 25 years after the last revision, in 2012 the FIGO Oncology Committee began revising the FIGO classification for staging ovarian, Fallopian tube and primary peritoneal cancers. The new classification has become effective with its publication at the beginning of 2014. Following recent findings on the pathogenesis of ovarian, Fallopian tube and primary peritoneal cancer and reflecting standard clinical practice, the three entities have now been classified uniformly. The histological subtype is included (high-grade serous - HGSC; low-grade serous - LGSC; mucinous - MC; clear cell - CCC; endometrioid - EC)...
October 2015: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/24947930/acquired-resistance-to-endocrine-treatments-is-associated-with-tumor-specific-molecular-changes-in-patient-derived-luminal-breast-cancer-xenografts
#3
Paul Cottu, Ivan Bièche, Franck Assayag, Rania El Botty, Sophie Chateau-Joubert, Aurélie Thuleau, Thomas Bagarre, Benoit Albaud, Audrey Rapinat, David Gentien, Pierre de la Grange, Vonick Sibut, Sophie Vacher, Rana Hatem, Jean-Luc Servely, Jean-Jacques Fontaine, Didier Decaudin, Jean-Yves Pierga, Sergio Roman-Roman, Elisabetta Marangoni
PURPOSE: Patients with luminal breast cancer (LBC) often become endocrine resistant over time. We investigated the molecular changes associated with acquired hormonoresistances in patient-derived xenografts of LBC. EXPERIMENTAL DESIGN: Two LBC xenografts (HBCx22 and HBCx34) were treated with different endocrine treatments (ET) to obtain xenografts with acquired resistances to tamoxifen (TamR) and ovariectomy (OvaR). PI3K pathway activation was analyzed by Western blot analysis and IHC and responses to ET combined to everolimus were investigated in vivo...
August 15, 2014: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/24920435/use-of-iota-simple-rules-for-diagnosis-of-ovarian-cancer-meta-analysis
#4
REVIEW
N Nunes, G Ambler, X Foo, J Naftalin, M Widschwendter, D Jurkovic
OBJECTIVES: To present data on prospective evaluation of the International Ovarian Tumor Analysis (IOTA) 'simple-rules' tool for the diagnosis of ovarian cancer and to perform a meta-analysis of studies that utilized the same diagnostic method. METHODS: In the present study a level-II ultrasound operator systematically assessed the tumors of women with an ultrasound diagnosis of adnexal tumor(s) according to the IOTA simple-rules protocol to determine the risk of the tumor being malignant...
November 2014: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/24771913/statement-by-the-kommission-ovar-of-the-ago-study-group-on-the-use-of-hipec-hyperthermic-intraperitoneal-chemotherapy-to-treat-primary-and-recurrent-ovarian-cancer
#5
P Harter, S Mahner, F Hilpert, I Runnebaum, O Ortmann, A Mustea, J Sehouli, A du Bois, U Wagner
HIPEC is offered to patients with ovarian, fallopian tube or primary peritoneal cancer at some hospitals. Altogether, there is still no evidence that HIPEC leads to an improvement of prognosis in any gynecologic tumor, neither in primary therapy nor in treatment of relapse. The available data indicate an increased complication rate which might negatively impact the benefit-risk balance of this procedure. In addition, standard treatment with proven efficacy might be withheld due to application of unproven methods...
March 2013: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/24457552/secondary-complete-cytoreduction-in-recurrent-ovarian-cancer-benefit-of-optimal-patient-selection-using-scoring-system
#6
MULTICENTER STUDY
Enora Laas, Mathieu Luyckx, Marjolein De Cuypere, Frederic Selle, Emile Daraï, Denis Querleu, Roman Rouzier, Elisabeth Chéreau
OBJECTIVE: Complete tumor cytoreduction seems to be beneficial for patients with recurrent epithelial ovarian cancer (REOC). The challenge is to identify patients eligible for such surgery. Several scores based on simple clinical parameters have attempted to predict resectability and help in patient selection for surgery in REOC.The aims of this study were to assess the performance of these models in an independent population and to evaluate the impact of complete resection. MATERIALS AND METHODS: A total of 194 patients with REOC between January 2000 and December 2010 were included in 2 French centers...
February 2014: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/23478059/abagovomab-as-maintenance-therapy-in-patients-with-epithelial-ovarian-cancer-a-phase-iii-trial-of-the-ago-ovar-cogi-gineco-and-geico-the-mimosa-study
#7
RANDOMIZED CONTROLLED TRIAL
Paul Sabbatini, Philipp Harter, Giovanni Scambia, Jalid Sehouli, Werner Meier, Pauline Wimberger, Klaus H Baumann, Christian Kurzeder, Barbara Schmalfeldt, David Cibula, Mariusz Bidzinski, Antonio Casado, Andrea Martoni, Nicoletta Colombo, Robert W Holloway, Luigi Selvaggi, Andrew Li, Jose del Campo, Karel Cwiertka, Tamas Pinter, Jan B Vermorken, Eric Pujade-Lauraine, Simona Scartoni, Monica Bertolotti, Cecilia Simonelli, Angela Capriati, Carlo Alberto Maggi, Jonathan S Berek, Jacobus Pfisterer
PURPOSE: To determine whether abagovomab maintenance therapy prolongs recurrence-free (RFS) and overall survival (OS) in patients with ovarian cancer in first clinical remission. PATIENTS AND METHODS: Patients with International Federation of Gynecology and Obstetrics stage III to IV ovarian cancer in complete clinical remission after primary surgery and platinum- and taxane-based chemotherapy were randomly assigned at a ratio of 2:1 in a phase III, double-blind, placebo-controlled, multicenter study...
April 20, 2013: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/22277193/implementing-an-online-tool-for-genome-wide-validation-of-survival-associated-biomarkers-in-ovarian-cancer-using-microarray-data-from-1287-patients
#8
Balázs Gyorffy, András Lánczky, Zoltán Szállási
The validation of prognostic biomarkers in large independent patient cohorts is a major bottleneck in ovarian cancer research. We implemented an online tool to assess the prognostic value of the expression levels of all microarray-quantified genes in ovarian cancer patients. First, a database was set up using gene expression data and survival information of 1287 ovarian cancer patients downloaded from Gene Expression Omnibus and The Cancer Genome Atlas (Affymetrix HG-U133A, HG-U133A 2.0, and HG-U133 Plus 2...
April 2012: Endocrine-related Cancer
https://www.readbyqxmd.com/read/21327421/retrospective-study-of-the-impact-of-pharmacogenetic-variants-on-paclitaxel-toxicity-and-survival-in-patients-with-ovarian-cancer
#9
Troels K Bergmann, Henrik Gréen, Charlotte Brasch-Andersen, Mansoor R Mirza, Jørn Herrstedt, Berit Hølund, Andreas du Bois, Per Damkier, Werner Vach, Kim Brosen, Curt Peterson
PURPOSE: Paclitaxel has a broad spectrum of anti-tumor activity and is useful in the treatment of ovarian, breast, and lung cancer. Paclitaxel is metabolized in the liver by CYP2C8 and CYP3A4 and transported by P-glycoprotein. The dose-limiting toxicities are neuropathy and neutropenia, but the interindividual variability in toxicity and also survival is large. The main purpose of this study was to investigate the impact of genetic variants in CYP2C8 and ABCB1 on toxicity and survival...
July 2011: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/21276234/phase-ii-study-evaluating-consolidation-whole-abdominal-intensity-modulated-radiotherapy-imrt-in-patients-with-advanced-ovarian-cancer-stage-figo-iii-the-ovar-imrt-02-study
#10
Nathalie Rochet, Meinhard Kieser, Florian Sterzing, Sonja Krause, Katja Lindel, Wolfgang Harms, Michael H Eichbaum, Andreas Schneeweiss, Christof Sohn, Juergen Debus
BACKGROUND: The prognosis for patients with advanced FIGO stage III epithelial ovarian cancer remains poor despite the aggressive standard treatment, consisting of maximal cytoreductive surgery and platinum-based chemotherapy. The median time to recurrence is less than 2 years, with a 5-years survival rate of -20-25%. Recurrences of the disease occur mostly intraperitoneally.Ovarian cancer is a radiosensitive tumor, so that the use of whole abdominal radiotherapy (WAR) as a consolidation therapy would appear to be a logical strategy...
2011: BMC Cancer
https://www.readbyqxmd.com/read/20629008/the-biological-and-clinical-value-of-p53-expression-in-pelvic-high-grade-serous-carcinomas
#11
MULTICENTER STUDY
Martin Köbel, Alexander Reuss, Andreas du Bois, Stefan Kommoss, Friedrich Kommoss, Dongxia Gao, Steve E Kalloger, David G Huntsman, C Blake Gilks
Studies on the p53 expression and outcome for women with ovarian carcinoma have produced conflicting results. The observed heterogeneity may be due to the range of cut-offs used to define overexpression and the mix of histotypes of the study cohorts. We aimed to examine the association between p53 expression and biological properties of tumours as well as outcome in 502 pelvic high-grade serous carcinomas (HGSCs) derived from two population-based cohorts from British Columbia representing cases with or without residual tumour after initial surgery, respectively, and one clinical trial cohort from Germany (AGO-OVAR-3)...
October 2010: Journal of Pathology
https://www.readbyqxmd.com/read/20165986/influence-of-residual-tumor-on-outcome-in-ovarian-cancer-patients-with-figo-stage-iv-disease-an-exploratory-analysis-of-the-ago-ovar-arbeitsgemeinschaft-gynaekologische-onkologie-ovarian-cancer-study-group
#12
Pauline Wimberger, Michael Wehling, Nils Lehmann, Rainer Kimmig, Barbara Schmalfeldt, Alexander Burges, Philipp Harter, Jacobus Pfisterer, Andreas du Bois
BACKGROUND: One of the most important prognostic factors in advanced ovarian cancer is the macroscopic absence of residual tumor after primary surgery. The impact of surgical outcome on the survival of patients with International Federation of Gynecology and Obstetrics (FIGO) stage IV disease is less clear and is the subject of this study. METHODS: Surgical and survival data were documented throughout the multicenter prospective randomized phase III trials of the AGO-OVAR (OVAR-3/-5/-7) and were used for this exploratory analysis...
June 2010: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/19560514/evaluation-of-the-vestibulo-ocular-reflex-using-sinusoidal-off-vertical-axis-rotation-in-patients-with-acoustic-neurinoma
#13
Akemi Sugita-Kitajima, Izumi Koizuka
The vestibulo-ocular reflex (VOR) was studied to examine the utility of off-vertical axis rotation (OVAR) in the diagnosis of acoustic neurinoma. Subjects were sinusoidally rotated with eyes open in complete darkness at frequencies of 0.4 and 0.8 Hz with a maximum angular velocity of 60 degrees /s at either earth-vertical axis rotation (EVAR) or OVAR. Thirteen patients with acoustic neurinomas were investigated. Results showed that VOR gain during OVAR at 0.8 Hz and in a 30 degrees nose-up position in patients with internal auditory canal tumors was significantly less than the gain measured during EVAR...
October 2, 2009: Neuroscience Letters
https://www.readbyqxmd.com/read/19258951/prognostic-value-of-human-epidermal-growth-factor-receptor-2-her-2-neu-in-patients-with-advanced-ovarian-cancer-treated-with-platinum-paclitaxel-as-first-line-chemotherapy-a-retrospective-evaluation-of-the-ago-ovar-3-trial-by-the-ago-ovar-germany
#14
RANDOMIZED CONTROLLED TRIAL
Jacobus Pfisterer, Andreas Du Bois, Eva-Katrin Bentz, Friedrich Kommoss, Philipp Harter, Jens Huober, Barbara Schmalfeldt, Nicole Burchardi, Norbert Arnold, Felix Hilpert
OBJECTIVES: Results on the prognostic value of human epidermal growth factor receptor 2 (HER-2)/neu in ovarian cancer are inconsistent. This exploratory analysis evaluates Her-2/neu as a prognostic factor in a large cohort of patients with advanced-stage ovarian cancer treated with platinum/paclitaxel as first-line chemotherapy within a prospective randomized trial. METHODS: Her-2/neu expression was assessed by immunohistochemistry in 359 patients (46%) treated within the AGO-OVAR 3 trial (n = 783)...
January 2009: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/19189349/role-of-surgical-outcome-as-prognostic-factor-in-advanced-epithelial-ovarian-cancer-a-combined-exploratory-analysis-of-3-prospectively-randomized-phase-3-multicenter-trials-by-the-arbeitsgemeinschaft-gynaekologische-onkologie-studiengruppe-ovarialkarzinom-ago
#15
RANDOMIZED CONTROLLED TRIAL
Andreas du Bois, Alexander Reuss, Eric Pujade-Lauraine, Philipp Harter, Isabelle Ray-Coquard, Jacobus Pfisterer
BACKGROUND: Primary surgery followed by platinum-taxane based chemotherapy has been the standard therapy in advanced ovarian cancer. However, the prognostic role of complete and so-called optimal and suboptimal debulking and its interaction with biological factors has not been not fully defined. METHODS: Exploratory analysis was conducted of 3 prospective randomized trials (AGO-OVAR 3, 5, and 7) investigating platinum-taxane based chemotherapy regimens in advanced ovarian cancer conducted between 1995 and 2002...
March 15, 2009: Cancer
https://www.readbyqxmd.com/read/19182313/-case-of-the-month-solitary-fibrous-tumor-of-the-pleura
#16
Ovar Arnarson, Tryggvi Thorgeirsson, Helgi J Isaksson, Fridrik Yngvason, Tomas Gudbjartsson
No abstract text is available yet for this article.
January 2009: Læknablađiđ
https://www.readbyqxmd.com/read/19172293/histological-grading-in-a-large-series-of-advanced-stage-ovarian-carcinomas-by-three-widely-used-grading-systems-consistent-lack-of-prognostic-significance-a-translational-research-subprotocol-of-a-prospective-randomized-phase-iii-study-ago-ovar-3-protocol
#17
MULTICENTER STUDY
Stefan Kommoss, Dietmar Schmidt, Friedrich Kommoss, Juergen Hedderich, Philipp Harter, Jacobus Pfisterer, Andreas du Bois
While there is no doubt that histologic grading is applicable in early stage ovarian carcinoma, it is still in controversial discussion concerning advanced stage ovarian carcinoma. It was the aim of this study to assess the three most widely used grading systems for ovarian carcinoma in terms of prognostic significance, concordance rates, and reproducibility in a large number of advanced stage ovarian carcinomas of all types after standardized chemotherapy. Representative hematoxylin and eosin slides from 334 cases of stage IIB-IV ovarian carcinoma (prospective randomized, multi-center, phase III study) were used...
March 2009: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/19093624/-treatment-of-the-peritoneal-carcinomatosis-by-cytoreductive-surgery-and-intraperitoneal-hyperthermic-chemotherapy-ihpc-postoperative-morbidity-and-mortality-and-short-term-follow-up
#18
COMPARATIVE STUDY
Annamaria Minicozzi, Giuseppe Borzellino, Emmanuel Nguefouet Momo, Christian Segattini, Federica Pitoni, Francesca Steccanella, Giovanni De Manzoni
BACKGROUND: In order to treat the peritoneal carcinomatosis from abdominal neoplasms has been recently proposed complete peritonectomy associated with IntraPeritoneal Hyperthermic Chemotherapy (IHPC). AIM OF THE STUDY: Estimate of postoperative morbidity and mortality and short-term outcome. METHODS: Twenty-four patients with peritoneal carcinomatosis or positive cytology at peritoneal washing were treated in our Department from January 2005 to October 2007...
July 2008: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/18726596/-central-pathology-review-inclusion-criterion-for-clinical-studies-of-ovarian-carcinomas
#19
RANDOMIZED CONTROLLED TRIAL
F Kommoss, S Kommoss, D Schmidt, A du Bois, J Pfisterer
Currently histopathological review is not standard practice in clinical studies of ovarian carcinomas. Published retrospective analyses as well as own unpublished observations have indicated that a certain percentage of study patients may have ovarian lesions other than ovarian carcinomas which may be in conflict with study inclusion criteria. In this context, the distinction of ovarian carcinomas from borderline tumors, ovarian metastases, and sex cord tumors has been shown to be a potential pitfall. In cases of incorrect diagnoses, non-beneficial morbidity at unnecessary high cost may occur, in other instances, more adequate therapeutic modalities might be withheld from a patient...
November 2008: Der Pathologe
https://www.readbyqxmd.com/read/18509180/incidence-of-venous-thromboembolism-in-patients-with-ovarian-cancer-undergoing-platinum-paclitaxel-containing-first-line-chemotherapy-an-exploratory-analysis-by-the-arbeitsgemeinschaft-gynaekologische-onkologie-ovarian-cancer-study-group
#20
Christina Fotopoulou, Andreas duBois, Alexandros N Karavas, Ralf Trappe, Behnaz Aminossadati, Barbara Schmalfeldt, Jacobus Pfisterer, Jalid Sehouli
PURPOSE: Venous thromboembolism (VTE) has been associated with negative prognosis in cancer patients. Most series reporting on VTE have included different tumor types not differentiating between recurrent or primary disease. Data regarding the actual impact of VTE on primary advanced ovarian cancer (AOC) are limited. PATIENTS AND METHODS: Between 1995 and 2002, the Arbeitsgemeinschaft Gynaekologische Onkologie Ovarian Cancer Study group (AGO-OVAR) recruited 2,743 patients with AOC in three prospectively randomized trials on platinum paclitaxel-based chemotherapy after primary surgery...
June 1, 2008: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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