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https://www.readbyqxmd.com/read/29786522/a-survey-of-experiences-of-uk-cattle-and-sheep-farmers-with-anthelmintic-prescribers-are-best-practice-principles-being-deployed-at-farm-level
#1
Easton Stephanie, L Pinchbeck Gina, J Bartley David, E Hodgkinson Jane, B Matthews Jacqueline
Helminths are common pathogens of ruminants. These are controlled by anthelmintics; however, resistance is a major issue. More sustainable practices need to be deployed to protect anthelmintic efficacy. There is no published information on how farmer/prescriber interactions at anthelmintic purchase shape application of best practice on-farm. To determine experiences of UK ruminant farmers as they relate to anthelmintic purchasing/provision of best practice advice at the point-of-sale, an online survey was distributed...
July 1, 2018: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29785478/changing-trend-of-infectious-diseases-in-nepal
#2
Shiba Kumar Rai
Many infectious/communicable diseases (IDs) are endemic in Nepal. Until a decade and half ago, IDs were the major cause of both morbidity and mortality accounting 70% for both. However, as a result of various preventive measures implemented by both the state and non-state actors, the overall IDs have shown a changing (declining) trend. The most impressive decline has been seen in the intestinal helminth infection. Though the overall burden of IDs is decreasing, several newer infectious diseases (emerging infections) namely, dengue fever, scrub typhus, influenza (H5N1 and H1N1), and others are posing a great public health problem...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29783251/prevalence-of-risk-factors-of-allergic-diseases-among-children-aged-8-9-years-in-poltava-region-the-results-of-the-first-stage-of-the-research
#3
Tetyana O Kryuchko, Iryna A Holovanova, Olha Y Tkachenko, Mariya O Melnyk, Kateryna V Pocheniuk
OBJECTIVE: Introduction: According to the European Academy of Allergology and Clinical Immunology (EAACI, 2016), allergy is the most common chronic disease in Europe. The aim: The aim of the investigation is to study the spread of risk factors of allergic reactions in children who are 8-9 years old of Poltava region. PATIENTS AND METHODS: Materials and methods: The investigation included two stages: the 1st contained interviewing; the 2nd one - additional clinical and lab investigation of children, who require the further diagnosis specification...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783021/a-hyper-diverse-genus-of-acanthocephalans-revealed-by-tree-based-and-non-tree-based-species-delimitation-methods-ten-cryptic-species-of-neoechinorhynchus-in-middle-american-freshwater-fishes
#4
Carlos Daniel Pinacho-Pinacho, Martín García-Varela, Ana L Sereno-Uribe, Gerardo Pérez-Ponce de León
The genus Neoechinorhynchus represents a hyper-diverse group of acanthocephalans, parasites of fresh and brackish water fish and freshwater turtles, with approximately 116 species described worldwide. Forty-nine species have been recorded in the Americas, nine of them in Middle America. Even though species delimitation methods using DNA sequences have been rarely used for parasitic helminths, the genetic library for species of Neoechinorhynchus has grown in the past few years, enhancing the possibility of using these methods for inferring evolutionary relationships and for establishing more robust species boundaries...
May 18, 2018: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/29779225/soil-transmitted-helminth-infections-associated-with-wastewater-and-sludge-reuse-a-review-of-current-evidence
#5
REVIEW
Isaac Dennis Amoah, Anthony Ayodeji Adegoke, Thor Axel Stenström
OBJECTIVE: To review current evidence on infections related to the concentration of soil-transmitted helminth (STH) eggs in wastewater, sludge and vegetables irrigated with wastewater or grown on sludge-amended soils. METHOD: Search of Web of Science, Science Direct, PubMed and Google Scholar databases for publications reporting on STH egg concentration in wastewater, sludge and vegetables and for epidemiological studies on wastewater/sludge reuse and STH infections...
May 19, 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29775454/in-vivo-and-in-vitro-studies-of-cry5b-and-nicotinic-acetylcholine-receptor-agonist-anthelmintics-reveal-a-powerful-and-unique-combination-therapy-against-intestinal-nematode-parasites
#6
Yan Hu, Melanie Miller, Bo Zhang, Thanh-Thanh Nguyen, Martin K Nielsen, Raffi V Aroian
BACKGROUND: The soil-transmitted nematodes (STNs) or helminths (hookworms, whipworms, large roundworms) infect the intestines of ~1.5 billion of the poorest peoples and are leading causes of morbidity worldwide. Only one class of anthelmintic or anti-nematode drugs, the benzimidazoles, is currently used in mass drug administrations, which is a dangerous situation. New anti-nematode drugs are urgently needed. Bacillus thuringiensis crystal protein Cry5B is a powerful, promising new candidate...
May 18, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29774301/-mansonella-perstans-onchocerca-volvulus-and-strongyloides-stercoralis-infections-in-rural-populations-in-central-and-southern-togo
#7
Francois Korbmacher, Kossi Komlan, Richard G Gantin, Wiyao P Poutouli, Koffi Padjoudoum, Potchoziou Karabou, Peter T Soboslay, Carsten Köhler
Background: Mansonella perstans , Onchocerca volvulus and Strongyloides stercoralis are widespread helminth parasites in the tropics. Their distribution remains difficult to determine as it may change during national disease control programs and with regional mass drug administration (MDA). Epidemiological surveys are of importance to evaluate the geographical distribution of these helminth parasites and the diseases they may cause, however, up to date epidemiological evaluations on M...
May 2018: Parasite Epidemiology and Control
https://www.readbyqxmd.com/read/29774300/epidemiology-of-intestinal-parasite-infections-in-three-departments-of-south-central-c%C3%A3-te-d-ivoire-before-the-implementation-of-a-cluster-randomised-trial
#8
Gaoussou Coulibaly, Mamadou Ouattara, Kouassi Dongo, Eveline Hürlimann, Fidèle K Bassa, Naférima Koné, Clémence Essé, Richard B Yapi, Bassirou Bonfoh, Jürg Utzinger, Giovanna Raso, Eliézer K N'Goran
Hundreds of millions of people are infected with helminths and intestinal protozoa, particularly children in low- and middle-income countries. Preventive chemotherapy is the main strategy to control helminthiases. However, rapid re-infection occurs in settings where there is a lack of clean water, sanitation and hygiene. In August and September 2014, we conducted a cross-sectional epidemiological survey in 56 communities of three departments of south-central Côte d'Ivoire. Study participants were invited to provide stool and urine samples...
May 2018: Parasite Epidemiology and Control
https://www.readbyqxmd.com/read/29774297/parasitic-and-zoonotic-meningoencephalitis-in-humans-and-equids-current-knowledge-and-the-role-of-halicephalobus-gingivalis
#9
REVIEW
ThankGod E Onyiche, Theresa O Okute, Oluwasina S Oseni, Dennis O Okoro, Abdullahi A Biu, Albert W Mbaya
Halicephalobus gingivalis is a saprophytic nematode parasite that causes a rare form of fatal meningoencephalomyelitis in equids, humans, and ruminants. This nematode has neurotropic activity, but has also been found in the kidney, liver, lungs, optic nerves and even heart of its host. Despite the zoonotic potential and severity of the disease, the epidemiology, pathogenesis, life cycle, and risk factors are poorly understood. Cases have been reported from several countries in Europe countries and North America but none is recorded in Africa except Egypt...
February 2018: Parasite Epidemiology and Control
https://www.readbyqxmd.com/read/29774289/high-prevalence-of-intestinal-worms-in-children-up-to-5-years-of-age-in-huaphan-province-lao-people-s-democratic-republic-pdr
#10
Naphavanh Nanthavong, Antony P Black, Phonepadith Khattignavong, Lavy Lorphachan, Keooudomphone Vilivong, Sylvie Goossens, Yves Buisson, Fabrice Quet, Claude P Muller, Satoshi Nakamura
Background: The prevalence of soil-transmitted helminth infection is high in Lao People's Democratic Republic (PDR), reaching 62% among school-children. However, this prevalence presents wide regional variations, due to differences in healthcare access and environmental factors. Curiously, there are few studies on helminth infections in pre-school children - an age group targeted by the national de-worming campaign. Therefore, a preliminary study was conducted in a remote region of Huaphan Province, North Laos, to determine the prevalence of helminth infections in pre-school children...
August 2017: Parasite Epidemiology and Control
https://www.readbyqxmd.com/read/29774287/prevalence-of-gastrointestinal-helminth-infections-of-dog-in-enugu-state-south-eastern-nigeria
#11
I K Idika, E C Onuorah, C F Obi, P U Umeakuana, C O Nwosu, D N Onah, S N Chiejina
The prevalence of gastrointestinal helminth infections of dog in Enugu State, South Eastern Nigeria was studied retrospectively and prospectively. In the retrospective study, records of all diagnosed helminth infections of dogs brought to the University of Nigeria Veterinary Teaching Hospital, Nsukka from January, 2006 to September 2013 were collated and analyzed. The prospective study was carried out between October 2013 and July 2014 by examination of 263 faecal samples collected per rectum from dogs presented to a purposively selected Veterinary Clinics in Enugu metropolis and the Veterinary Teaching Hospital of the University of Nigeria, Nsukka...
August 2017: Parasite Epidemiology and Control
https://www.readbyqxmd.com/read/29772478/bacillus-thuringiensis-cry5b-protein-as-a-new-pan-hookworm-cure
#12
Yan Hu, Thanh-Thanh Nguyen, Alice C Y Lee, Joseph F Urban, Melanie M Miller, Bin Zhan, David J Koch, Jason B Noon, Ambily Abraham, Ricardo Toshio Fujiwara, Dwight D Bowman, Gary R Ostroff, Raffi V Aroian
Hookworms are intestinal nematode parasites that infect nearly half a billion people and are globally one of the most important contributors to iron-deficiency anemia. These parasites have significant impacts in developing children, pregnant women and working adults. Of all the soil-transmitted helminths or nematodes (STNs), hookworms are by far the most important, with disease burdens conservatively estimated at four million DALYs (Disability-Adjusted Life Years) and with productivity losses of up to US$139 billion annually...
May 4, 2018: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/29772005/atrophy-of-skin-draining-lymph-nodes-predisposes-for-impaired-immune-responses-to-secondary-infection-in-mice-with-chronic-intestinal-nematode-infection
#13
Xiaogang Feng, Cajsa Classon, Graciela Terán, Yunlong Yang, Lei Li, Sherwin Chan, Ulf Ribacke, Antonio Gigliotti Rothfuchs, Jonathan M Coquet, Susanne Nylén
Intestinal nematodes suppress immune responses in the context of allergy, gut inflammation, secondary infection and vaccination. Several mechanisms have been proposed for this suppression including alterations in Th2 cell differentiation and increased Treg cell suppressive function. In this study, we show that chronic nematode infection leads to reduced peripheral responses to vaccination because of a generalized reduction in the available responsive lymphocyte pool. We found that superficial skin-draining lymph nodes (LNs) in mice that are chronically infected with the intestinal nematode Heligmosomides polygyrus, do not reach the same cellularity as worm-free mice upon subsequent BCG infection in the skin...
May 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29761467/using-wormbase-parasite-an-integrated-platform-for-exploring-helminth-genomic-data
#14
Bruce J Bolt, Faye H Rodgers, Myriam Shafie, Paul J Kersey, Matthew Berriman, Kevin L Howe
WormBase ParaSite ( parasite.wormbase.org ) is a comprehensive resource for the genomes of parasitic nematodes and flatworms (helminths). It currently includes genomic data for over 100 helminth species, adding value by way of consistent functional annotation, gene comparative analysis and gene expression analysis. We provide several ways of exploring the data including a choice of genome browsers, genome and gene summary pages, text and sequence searching, a query wizard, bulk downloads, and programmatic interfaces...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29761465/a-multi-omics-database-for-parasitic-nematodes-and-trematodes
#15
John Martin, Rahul Tyagi, Bruce A Rosa, Makedonka Mitreva
Helminth.net ( www.helminth.net ) is a web-based resource that was launched in 2000 as simply " Nematode.net " to host and investigate gene sequences from nematode genomes. Over the years it has evolved to become the moniker for a collection of databases: Nematode.net and Trematode.net . These databases host information for 73 nematode (roundworms) and 17 trematode (flatworms) species and serve as backbone for a number of tools that allow users to query slices of the data for multifactorial combinations of species-omics properties...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29761403/characterizing-activation-proliferation-and-ontogeny-of-murine-macrophages-in-parasitic-helminth-infections
#16
Dominik Rückerl
Helminth parasites infect approximately 1/3 of the human population. They induce a characteristic immune response whose main focus seems to be to contain the worm parasites and avoid excessive damage to the host. Macrophages are a central player in this response and research using helminth infection models has highlighted the heterogeneity of macrophage responses including distinct recruitment mechanisms, subset-specific activation profiles, and functional diversity. Thus, helminth infection models offer the excellent opportunity to analyze a unique part of the macrophage activation spectrum as well as dissect the functional contributions of macrophages to a wide variety of biologically relevant conditions like wound healing, fibrosis, and immunoregulation...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29760697/hookworm-secreted-extracellular-vesicles-interact-with-host-cells-and-prevent-inducible-colitis-in-mice
#17
Ramon M Eichenberger, Stephanie Ryan, Linda Jones, Geraldine Buitrago, Ramona Polster, Marcela Montes de Oca, Jennifer Zuvelek, Paul R Giacomin, Lindsay A Dent, Christian R Engwerda, Matthew A Field, Javier Sotillo, Alex Loukas
Gastrointestinal (GI) parasites, hookworms in particular, have evolved to cause minimal harm to their hosts, allowing them to establish chronic infections. This is mediated by creating an immunoregulatory environment. Indeed, hookworms are such potent suppressors of inflammation that they have been used in clinical trials to treat inflammatory bowel diseases (IBD) and celiac disease. Since the recent description of helminths (worms) secreting extracellular vesicles (EVs), exosome-like EVs from different helminths have been characterized and their salient roles in parasite-host interactions have been highlighted...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29760143/developmental-sensitivity-in-schistosoma-mansoni-to-puromycin-to-establish-drug-selection-of-transgenic-schistosomes
#18
Hong-Bin Yan, Michael J Smout, Chuan Ju, Anne E Folley, Danielle E Skinner, Victoria H Mann, Alex Loukas, Wei Hu, Paul J Brindley, Gabriel Rinaldi
Schistosomiasis is considered the most important disease caused by helminth parasites, in terms of morbidity and mortality. Tools to facilitate gain- and loss- of-function approaches can be expected to precipitate the discovery of novel interventions, and drug selection of transgenic schistosomes would facilitate the establishment of stable lines of engineered parasites. Sensitivity of developmental stages of schistosomes to the aminonucleoside antibiotic puromycin was investigated. For the schistosomulum and sporocyst stages, viability was quantified by fluorescence microscopy following dual staining with fluorescein diacetate and propidium iodine...
May 14, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29753341/human-parasitology-and-parasitic-diseases-heading-towards-2050
#19
Peter J Hotez
By 2050 our civilized planet may be comprised predominantly of networked megacities embedded in warm subtropical and tropical climates, and under stress from climate change and catastrophic weather events. Urban slum areas in these cities, including those found in wealthier middle- and high-income nations (blue marble health), will be especially vulnerable to disease. Moreover, regional conflicts fought over shifting and limited resources, including water, will collapse health systems infrastructures to further promote disease emergence and reemergence...
2018: Advances in Parasitology
https://www.readbyqxmd.com/read/29753337/100-years-of-mass-deworming-programmes-a-policy-perspective-from-the-world-bank-s-disease-control-priorities-analyses
#20
Donald A P Bundy, Laura J Appleby, Mark Bradley, Kevin Croke, T Deirdre Hollingsworth, Rachel Pullan, Hugo C Turner, Nilanthi de Silva
For more than 100 years, countries have used mass drug administration as a public health response to soil-transmitted helminth infection. The series of analyses published as Disease Control Priorities is the World Bank's vehicle for exploring the cost-effectiveness and value for money of public health interventions. The first edition was published in 1993 as a technical supplement to the World Bank's World Development Report Investing in Health where deworming was used as an illustrative example of value for money in treating diseases with relatively low morbidity but high prevalence...
2018: Advances in Parasitology
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