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https://www.readbyqxmd.com/read/28942767/measuring-the-effect-of-soil-transmitted-helminth-infections-on-cognitive-function-in-children-systematic-review-and-critical-appraisal-of-evidence
#1
Kei Owada, Mark Nielsen, Colleen L Lau, Archie C A Clements, Laith Yakob, Ricardo J Soares Magalhães
Recently the role of soil-transmitted helminth (STH) infections in children's cognitive developmental impairment has been under scrutiny. We conducted a systematic review of the evidence for associations between STH infections and cognitive function of children using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocol. We aimed to identify the domains of cognitive function in three age strata (<24months, 24-59months and ≥60months) and critically appraise the general design protocol of the studies, with a focus on the cognitive function measurement tools used...
2017: Advances in Parasitology
https://www.readbyqxmd.com/read/28942117/helminth-log-reduction-values-for-recycling-water-from-sewage-for-the-protection-of-human-and-stock-health
#2
Daryl P Stevens, Aravind Surapaneni, Rachna Thodupunuri, Nicholas A O'Connor, David Smith
The LRVs required to decrease HE concentrations in raw sewage to an acceptable level to manage the risk to human and livestock health were determined. An LRV of 3.0 was required to meet the HBT of 1 μDALY pppy in SE Australia where human helminth infections are not endemic. In comparison, a similar exposure volume and LRV in endemic regions would result in a HBT of 100 μDALY pppy. The risks posed by cattle- and pig-related helminths were also managed acceptably with the treatment of sewage providing an LRV of 3...
August 30, 2017: Water Research
https://www.readbyqxmd.com/read/28942049/purification-of-native-m-vogae-and-h-contortus-tubulin-by-tog-affinity-chromatography
#3
Beatriz Munguía, Ramiro Teixeira, Victoria Veroli, Elisa Melian, Jenny Saldaña, Mahia Minteguiaga, Mario Señorale, Mónica Marín, Laura Domínguez
Microtubules are non-covalent cylindrical polymers formed by alpha- and beta-tubulin heterodimer units, crucial for cell division, intracellular transport, motility and differentiation. This makes them very attractive pharmacological targets exploited to develop different drugs such as anthelmintics, antifungals, and antineoplastics. In this work, in order to establish an in vitro target-based screen to integrate to the search for new anthelmintics, we explored the extraction of native assembly-competent tubulin from two helminth parasites: Mesocestoides vogae tetrathyridia (syn...
September 20, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28938014/intestinal-helminth-infection-drives-carcinogenesis-in-colitis-associated-colon-cancer
#4
Eva Pastille, Annika Frede, Henry J McSorley, Jessica Gräb, Alexandra Adamczyk, Sebastian Kollenda, Wiebke Hansen, Matthias Epple, Jan Buer, Rick M Maizels, Robert Klopfleisch, Astrid M Westendorf
Inflammatory bowel diseases (IBD) are chronic inflammatory disorders of the gastrointestinal tract, strongly associated with an increased risk of colorectal cancer development. Parasitic infections caused by helminths have been shown to modulate the host's immune response by releasing immunomodulatory molecules and inducing regulatory T cells (Tregs). This immunosuppressive state provoked in the host has been considered as a novel and promising approach to treat IBD patients and alleviate acute intestinal inflammation...
September 22, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28935612/use-of-aflp-for-the-study-of-eukaryotic-pathogens-affecting-humans
#5
REVIEW
Carlos M Restrepo, Alejandro Llanes, Ricardo Lleonart
Amplified fragment length polymorphism (AFLP) is a genotyping technique based on PCR amplification of specific restriction fragments from a particular genome. The methodology has been extensively used in plant biology to solve a variety of scientific questions, including taxonomy, molecular epidemiology, systematics, population genetics, among many others. The AFLP share advantages and disadvantages with other types of molecular markers, being particularly useful in organisms with no previous DNA sequence knowledge...
September 18, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28929415/pediatric-neurocysticercosis
#6
REVIEW
Pratibha Singhi, Arushi Gahlot Saini
Neurocysticercosis is the most common helminth infection of nervous system in humans caused by the encysted larvae of Taenia solium. It is a major cause of epilepsy in tropical areas and the most common cause of focal-onset seizures in North Indian children. Children with neurocysticercosis have pleomorphic manifestations depending on the location, number and viability of the cysts and host response. In endemic areas, neurocysticercosis should be clinically suspected in any child with recent-onset seizures, headache or focal motor deficits where there is no other suggestion of an underlying neurological disorder...
September 20, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28928945/pathogenic-helminths-in-the-past-much-ado-about-nothing
#7
Christian Mulder
Despite a long tradition on the extent to which Romanisation has improved human health, some recent studies suggest that Romanisation in general, and Roman sanitation in particular, may not have made people any healthier, given that in Roman times gastrointestinal parasites were apparently widespread, whilst in the present day such parasites rarely cause diseases. Unfortunately, this novel claim neglects the empirical evidence that worldwide infections in over 1.5 billion people are caused by ubiquitous foodborne nematodes...
2017: F1000Research
https://www.readbyqxmd.com/read/28926696/exposure-to-animal-feces-and-human-health-a-systematic-review-and-proposed-research-priorities
#8
Gauthami Penakalapati, Jenna Swarthout, Miranda J Delahoy, Lydia McAliley, Breanna Wodnik, Karen Levy, Matthew C Freeman
Humans can be exposed to pathogens from poorly managed animal feces, particularly in communities where animals live in proximity to humans. This systematic review of peer-reviewed and grey literature examines the human health impacts of exposure to poorly managed animal feces transmitted via water, sanitation, and hygiene (WASH)-related pathways in low- and middle-income countries where household livestock, small-scale animal operations, and free-roaming animals are common. We identify routes of contamination by animal feces, control measures to reduce human exposure, and propose research priorities for further inquiry...
September 19, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28926584/transcriptome-analysis-reveals-molecular-anthelmintic-effects-of-procyanidins-in-c-elegans
#9
Verena Spiegler, Andreas Hensel, Jochen Seggewiß, Milena Lubisch, Eva Liebau
Worldwide, more than 1 billion people are affected by infestations with soil-transmitted helminths and also in veterinary medicine helminthiases are a severe threat to livestock due to emerging resistances against the common anthelmintics. Proanthocyanidins have been increasingly investigated for their anthelmintic properties, however, except for an interaction with certain proteins of the nematodes, not much is known about their mode of action. To investigate the anthelmintic activity on a molecular level, a transcriptome analysis was performed in Caenorhabditis elegans after treatment with purified and fully characterized oligomeric procyanidins (OPC)...
2017: PloS One
https://www.readbyqxmd.com/read/28924741/spectrum-of-infectious-diseases-among-newly-arrived-eritrean-refugees-in-switzerland-a-cross-sectional-study
#10
Afona Chernet, Andreas Neumayr, Christoph Hatz, Kerstin Kling, Véronique Sydow, Katharina Rentsch, Jürg Utzinger, Nicole Probst-Hensch, Hanspeter Marti, Beatrice Nickel, Niklaus D Labhardt
OBJECTIVES: Our study aimed at determining the prevalence of selected infectious diseases among recently arrived Eritrean refugees in Switzerland. METHODS: In this cross-sectional study, asymptomatic Eritrean migrants aged ≥16 years who arrived <24 months ago were recruited at refugee centres in Switzerland. Infectious disease screening included serology for HIV, hepatitis B and C, syphilis and schistosomiasis, polymerase chain reaction (PCR) for malaria, stool microscopy for helminths and intestinal protozoa and circulating cathodic antigen (CCA) testing in urine for schistosomiasis...
September 19, 2017: International Journal of Public Health
https://www.readbyqxmd.com/read/28924616/soil-transmitted-helminth-infections-are-not-associated-with-compromised-antibody-responses-to-previously-administered-measles-and-tetanus-vaccines-among-hiv-1-infected-art-na%C3%A3-ve-kenyan-adults
#11
Helen L Storey, Benson Singa, Jackie Naulikha, Helen Horton, Barbra A Richardson, Grace John-Stewart, Judd L Walson
In many regions of sub-Saharan Africa, both HIV and helminth infections are prevalent. HIV-1 (human immunodeficiency virus type 1) and helminth infections can both compromise immune responses in humans. To determine whether the presence of helminth infection or the treatment of helminth infection alters unstimulated vaccine responses among HIV-1 infected individuals, we conducted two nested serologic studies. Blood samples were collected for HIV disease monitoring and vaccine-specific serologic assays, while stool was evaluated by direct microscopy methods...
February 2017: Parasite Epidemiology and Control
https://www.readbyqxmd.com/read/28923765/preparation-and-investigation-of-p28gst-loaded-plga-microparticles-for-immunomodulation-of-experimental-colitis
#12
T H Hoang Thi, P A Priemel, Y Karrout, V Driss, M Delbeke, A Dendooven, M P Flament, M Capron, J Siepmann
The aim of this work was to prepare and characterize (in vitro and in vivo) PLGA-based microparticles loaded with an enzymatic protein derived from the helminth parasite Schistosoma haematobium: glutathione S-transferase P28GST (P28GST). This protein is not only a promising candidate vaccine against schistosomiasis, it also exhibits interesting immunomodulating effects, which can be helpful for the regulation of inflammatory diseases. Helminths express a regulatory role on intestinal inflammation, and immunization by P28GST has recently been shown to be as efficient as infection to reduce inflammation in a murine colitis model...
September 15, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28923008/an-eleven-year-retrospective-hospital-based-study-of-epidemiological-data-regarding-human-strongyloidiasis-in-northeast-thailand
#13
Thidarat K Prasongdee, Pokkamol Laoraksawong, Wanida Kanarkard, Ratthaphol Kraiklang, Kraisit Sathapornworachai, Sureeporn Naonongwai, Porntip Laummaunwai, Oranuch Sanpool, Pewpan M Intapan, Wanchai Maleewong
BACKGROUND: Human strongyloidiasis is a chronic and persistent gastrointestinal disease caused by infection with soil-transmitted helminths of the genus Strongyloides. The aim of this research was to obtain diagnostic prevalence regarding strongyloidiasis in northeast Thailand through a hospital-based study. METHODS: Patients' demographic data and the results of stool examinations conducted using the formalin ethyl acetate concentration technique were collected from the parasitology laboratory records at Srinagarind Hospital in Khon Kaen, Thailand...
September 18, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28917298/high-prevalence-of-bovine-cysticercosis-found-during-evaluation-of-different-post-mortem-detection-techniques-in-belgian-slaughterhouses
#14
Famke Jansen, Pierre Dorny, Dirk Berkvens, Anke Van Hul, Nick Van den Broeck, Caroline Makay, Nicolas Praet, Ramon Marc Eichenberger, Peter Deplazes, Sarah Gabriël
Bovine cysticercosis (BCC), caused by the helminth Taenia saginata, is currently diagnosed solely by official meat inspection (MI) based on macroscopic detection of viable cysticerci or typical lesions of degenerated larvae. MI has a known low sensitivity (<16%), leading to a large proportion of infected cattle carcasses entering the human food chain and posing a risk to public health. Prevalence in Belgium based on MI results is estimated at around 0.22%. Due to the low sensitivity of MI, alternative techniques to detect BCC should be considered...
September 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28913695/comparison-of-helminth-community-of-apodemus-agrarius-and-apodemus-flavicollis-between-urban-and-suburban-populations-of-mice
#15
Dorota Dwużnik, Tomasz Gortat, Jerzy M Behnke, Alicja Gryczyńska, Małgorzata Bednarska, Antoni S Mikoszewski, Michał Kozakiewicz, Anna Bajer
The growing human population and the development of urban areas have led to fragmentation and destruction of many natural habitats but have also created new urban habitats. These environmental changes have had a negative impact on many species of plants and animals, including parasite communities. The aim of present study was to compare the helminth communities of Apodemus flavicollis and Apodemus agrarius in natural and urban habitats. Helminth burdens were assessed in 124 mice, 48 A. flavicollis, and 76 A...
September 14, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28911129/a-comparative-study-on-the-efficacy-of-praziquantel-and-albendazole-in-the-treatment-of-urinary-schistosomiasis-in-adim-cross-river-state-nigeria
#16
S A Ben, M F Useh
Background: Praziquantel (PZQ) is the current drug of choice for the treatment of urinary schistosomiasis in endemic areas. It is very efficacious, although the potential for the development of resistance has been reported in some endemic areas among human subjects and in animal studies. Its' limitation include high cost and administration of multiple numbers of tablets. Albendazole (ALB) is used in the treatment of intestinal helminths infection. It is a broad-spectrum single-dose antihelminthic with an excellent cure rate and safety criteria...
September 1, 2017: International Health
https://www.readbyqxmd.com/read/28906438/acetylcholinesterase-and-nicotinic-acetylcholine-receptors-in-schistosomes-and-other-parasitic-helminths
#17
REVIEW
Hong You, Chang Liu, Xiaofeng Du, Donald P McManus
Schistosomiasis, which is caused by helminth trematode blood flukes of the genus Schistosoma, is a serious health and economic problem in tropical areas, and the second most prevalent parasitic disease after malaria. Currently, there is no effective vaccine available and treatment is entirely dependent on a single drug, praziquantel (PZQ), raising a significant potential public health threat due to the emergence of PZQ drug resistance. It is thus urgent and necessary to explore novel therapeutic targets for the treatment of schistosomiasis...
September 14, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28906255/echinococcus-multilocularis-vesicular-fluid-inhibits-activation-and-proliferation-of-natural-killer-cells
#18
Anne-Pauline Bellanger, Valentine Mougey, Jean-Rene Pallandre, Houssein Gbaguidi-Haore, Yann Godet, Laurence Millon
Alveolar echinococcosis is a severe chronic helminthic disease that mimics slow-growing liver cancer. The immune evasion strategy of Echinococcus multilocularis Leuckart, 1863 remains poorly understood. The aim of this study was to investigate in vitro the impact of E. multilocularis vesicular fluid (Em-VF) on peripheral blood mononuclear cells (PBMC) and on natural killer (NK) cells. PBMC and NK cells were exposed to Em-VF (1 µg/ml) during six days. The effect of Em-VF was assessed on CD69, viability and proliferation, and on and transforming growth factor β (TGF-β), interferon γ (IFN-γ), interleukin 17 (IL-17) and interleukin 10, using flow cytometry and ELISA, respectively...
August 25, 2017: Folia Parasitologica
https://www.readbyqxmd.com/read/28906131/effects-of-immunomodulators-on-the-response-induced-by-vaccines-against-autoimmune-diseases
#19
Dante J Marciani
A promising treatment for T-cell-mediated autoimmune diseases is the induction of immune tolerance by modulating the immune response against self-antigens, an objective that may be achieved by vaccination. There are two main types of vaccines currently under development. The tolerogenic vaccines, composed of proteins formed by a cytokine fused to a self-antigen, which usually induce tolerance by eliminating the T-cells that are immune reactive against the self-antigen. The immunogenic vaccines, comprised of a self-antigen plus a sole Th2 adjuvant either free or conjugated, that alleviate autoimmunity by switching the immune response against the self-antigen, from a damaging pro-inflammatory Th1/Th17 to an anti-inflammatory Th2 immunity...
September 14, 2017: Autoimmunity
https://www.readbyqxmd.com/read/28903890/human-parasitic-diseases-in-bulgaria-2013-2014
#20
Iskra Rainova, Rumen Harizanov, Iskren Kaftandjiev, Nina Tsvetkova, Ognyan Mikov, Eleonora Kaneva
BACKGROUND: In Bulgaria, more than 20 autochthonous human parasitic infections have been described and some of them are widespread. Over 50 imported protozoan and helminthic infections represent diagnostic and therapeutic challenge and pose epidemiological risk due to the possibility of local transmission. AIMS: To establish the distribution of autochthonous and imported parasitic diseases among the population of the country and to evaluate their significance for the public health system...
September 13, 2017: Balkan Medical Journal
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