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Babesiosis

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https://www.readbyqxmd.com/read/27911903/transfected-babesia-bovis-expressing-a-tick-gst-as-a-live-vector-vaccine
#1
Daiane P Oldiges, Jacob M Laughery, Nelson Junior Tagliari, Ronaldo Viana Leite Filho, William C Davis, Itabajara da Silva Vaz, Carlos Termignoni, Donald P Knowles, Carlos E Suarez
The Rhipicephalus microplus tick is a notorious blood-feeding ectoparasite of livestock, especially cattle, responsible for massive losses in animal production. It is the main vector for transmission of pathogenic bacteria and parasites, including Babesia bovis, an intraerythrocytic apicomplexan protozoan parasite responsible for bovine Babesiosis. This study describes the development and testing of a live B. bovis vaccine expressing the protective tick antigen glutathione-S-transferase from Haemaphysalis longicornis (HlGST)...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27911694/seroprevalence-of-babesia-microti-in-individuals-with-lyme-disease
#2
Sabino R Curcio, Laurel P Tria, Azad L Gucwa
INTRODUCTION: Babesiosis is an emerging tick-borne disease (TBD) caused by Babesia microti, an intracellular parasite of red blood cells. Currently, it is the highest ranked pathogen transmitted by blood transfusion. Most healthy individuals infected with B. microti are asymptomatic, but may be at risk for chronic infection. Similar to Lyme disease transmitted by Borrelia burgdorferi, B. microti is spread by Ixodes scapularis ticks. The rate of coinfection with these TBDs in humans is unclear as most studies have focused their prevalence in ticks or rodent reservoirs...
December 2016: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/27884441/trypanosoma-vivax-in-water-buffalo-of-the-venezuelan-llanos-an-unusual-outbreak-of-wasting-disease-in-an-endemic-area-of-typically-asymptomatic-infections
#3
Herakles A Garcia, Oneyda J Ramírez, Carla M F Rodrigues, Rafael G Sánchez, Angelica M Bethencourt, Gabriela Del M Pérez, Antonio H H Minervino, Adriana C Rodrigues, Marta M G Teixeira
Trypanosoma vivax has been associated with asymptomatic infections in African and South American buffalo. In this study, T. vivax was analyzed in water buffalo (Bubalus bubalis) from Venezuela in a molecular survey involving 293 blood samples collected from 2006 to 2015 across the Llanos region. Results demonstrated constant infections (average 23%) during the years analyzed. In general, animals were healthy carriers of T. vivax with low levels of parasitemia and were diagnosed exclusively by TviCATL-PCR. However, an outbreak of severe acute infections mostly in dairy animals was reported during a prolonged drought affecting 30...
October 30, 2016: Veterinary Parasitology
https://www.readbyqxmd.com/read/27876993/a-unique-case-of-babesia-gibsoni-infected-dog-with-paraplegia
#4
Suresh Gonde, S Chhabra, S K Uppal, L D Singla, S S Randhawa
A 4 year old male Rottweiler was presented to Teaching Veterinary Clinics of GADVASU with a primary complaint of paraplegia, fever and inappetence. The dog was found to be dull with elevated rectal temperature (105 °F), heart rate (158 per minute) and respiration rate (57 per minute). Blood smear examination and PCR assay revealed that dog was positive for Babesia gibsoni. Elevated bilirubin, alanine aminotransferase, alkaline phosphatase, creatinine, total leucocyte count, neutrophils and hypoglycaemia were haemato-biochemical alterations...
December 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/27876992/traditional-versus-molecular-based-detection-of-a-rare-occurrence-of-babesiosis-in-gir-calf-and-its-therapeutic-management
#5
Biswa Ranjan Maharana, Binod Kumar, Nitinkumar Devrajbhai Hirani
A 30-day old Gir calf was brought to Veterinary Polyclinic with symptoms of high fever, dullness, dyspnea, pale mucus membrane and haemoglobinuria. Blood sample was collected and microscopic examination of thin blood smear confirmed the case of acute babesiosis. It was further confirmed by polymerase chain reaction that amplified an approximately 410 bp portion of the ssu-rDNA of Babesia spp. The calf was managed with diminazene aceturate @5 mg/kg (Berenil) intramuscularly followed by supportive therapy including intravenous infusions...
December 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/27876977/a-study-on-prevalence-and-identification-of-ovine-theileria-and-babesia-infection-in-zabol-using-pcr-method
#6
Neda Sharifi, Maryam Ganjali, Reza Nabavi, Dariush Saadati
Infection with Babesia and Theileria Causes high mortality and economical losses in livestock and has a relatively high prevalence in Iran. In Zabol, animals are susceptible to this disease because of presence of vector ticks, weather conditions and smuggle animal across the border and they cause great damages to the economy and production. However, few studies have been done for differentiation of Theileria and Babesia in sheep in this area. The purpose of the present study was to determine the prevalence of Babesiosis and Theileriosis in sheep in Zabol...
December 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/27876923/escalations-in-the-incidence-of-canine-babesiosis-over-a-period-of-8%C3%A2-years-2006-2013-in-chennai-tamil-nadu-india
#7
Latha Bhaskaran Ravi, Dhivya Bhoopathy, Vairamuthu Subbiah
Epidemiological studies on the incidence and prevalence of disease will help in the monitoring and surveillance of diseases thus preventing occurrence of an epidemic. This study focuses on the variations in the incidences of canine babesiosis over a period of 8 years in Chennai. Variations have been noticed to in the incidence of the species of Babesia affecting dogs. There has been an escalation in the incidence of B.gibsoni infection during the study period. The factors such as seasonal, age, sex and breed influences on the incidence have been studied...
December 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/27876900/the-common-zoonotic-protozoal-diseases-causing-abortion
#8
REVIEW
Raafat Mohamed Shaapan
Toxoplasmosis, neosporosis, sarcosporidiosis (sarcocystosis) and trypanosomiasis are the common zoonotic protozoal diseases causing abortion which caused by single-celled protozoan parasites; Toxoplasma gondii, Neospora caninum, Sarcocystis spp and Trypanosoma evansi, respectively. Toxoplasmosis is generally considered the most important disease that causing abortion of both pregnant women and different female animals throughout the world, about third of human being population had antibodies against T. gondii...
December 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/27842609/a-recombinant-multi-antigen-vaccine-formulation-containing-babesia-bovis-merozoite-surface-antigens-msa-2a1-msa-2b-and-msa-2c-elicits-invasion-inhibitory-antibodies-and-ifn-%C3%AE-producing-cells
#9
Alba Marina Gimenez, Katia S Françoso, Jonatan Ersching, Marcelo Y Icimoto, Vitor Oliveira, Anabel E Rodriguez, Leonhard Schnittger, Monica Florin-Christensen, Mauricio M Rodrigues, Irene S Soares
BACKGROUND: Babesia bovis is a tick-transmitted protozoan hemoparasite and the causative agent of bovine babesiosis, a potential risk to more than 500 million cattle worldwide. The vaccines currently available are based on attenuated parasites, which are difficult to produce, and are only recommended for use in bovines under one year of age. When used in older animals, these vaccines may cause life-threatening clinical symptoms and eventually death. The development of a multi-subunit recombinant vaccine against B...
November 14, 2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27832060/comparative-bioinformatics-analysis-of-transcription-factor-genes-indicates-conservation-of-key-regulatory-domains-among-babesia-bovis-babesia-microti-and-theileria-equi
#10
REVIEW
Heba F Alzan, Donald P Knowles, Carlos E Suarez
Apicomplexa tick-borne hemoparasites, including Babesia bovis, Babesia microti, and Theileria equi are responsible for bovine and human babesiosis and equine theileriosis, respectively. These parasites of vast medical, epidemiological, and economic impact have complex life cycles in their vertebrate and tick hosts. Large gaps in knowledge concerning the mechanisms used by these parasites for gene regulation remain. Regulatory genes coding for DNA binding proteins such as members of the Api-AP2, HMG, and Myb families are known to play crucial roles as transcription factors...
November 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27796110/confirmation-of-occurrence-of-i-babesia-vogeli-i-in-a-dog-in-windhoek-central-namibia
#11
Barend L Penzhorn, Ilse Vorster, Gernot Redecker, Marinda C Oosthuizen
Although there is evidence of high seroprevalence of antibodies to Babesia spp. in dogs in central Namibia, clinical babesiosis is rarely diagnosed. Rhipicephalus sanguineus sensu lato, the vector of Babesia vogeli, is common in Namibia while Haemaphysalis elliptica, the vector of the highly virulent but morphologically indistinguishable Babesia rossi, has rarely been recorded, mainly in northern Namibia. On the basis of vector occurrence, clinical cases of canine babesiosis in Windhoek, central Namibia, have been ascribed to B...
October 26, 2016: Journal of the South African Veterinary Association
https://www.readbyqxmd.com/read/27784333/genomic-resources-for-a-unique-low-virulence-babesia-taxon-from-china
#12
Guiquan Guan, Pasi K Korhonen, Neil D Young, Anson V Koehler, Tao Wang, Youquan Li, Zhijie Liu, Jianxun Luo, Hong Yin, Robin B Gasser
BACKGROUND: Babesiosis is a socioeconomically important tick-borne disease of animals (including humans) caused by haemoprotozoan parasites. The severity of babesiosis relates to host and parasite factors, particularly virulence/pathogenicity. Although Babesia bovis is a particularly pathogenic species of cattle, there are species of Babesia of ruminants that have limited pathogenicity. For instance, the operational taxonomic unit Babesia sp. Xinjiang (abbreviated here as Bx) of sheep from China is substantially less virulent/pathogenic than B...
October 27, 2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27767010/transmission-of-babesia-microti-parasites-by-solid-organ-transplantation
#13
Meghan B Brennan, Barbara L Herwaldt, James J Kazmierczak, John W Weiss, Christina L Klein, Catherine P Leith, Rong He, Matthew J Oberley, Laura Tonnetti, Patricia P Wilkins, Gregory M Gauthier
Babesia microti, an intraerythrocytic parasite, is tickborne in nature. In contrast to transmission by blood transfusion, which has been well documented, transmission associated with solid organ transplantation has not been reported. We describe parasitologically confirmed cases of babesiosis diagnosed ≈8 weeks posttransplantation in 2 recipients of renal allografts from an organ donor who was multiply transfused on the day he died from traumatic injuries. The organ donor and recipients had no identified risk factors for tickborne infection...
November 2016: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/27758918/tracing-disease-emergence-canine-babesiosis-in-the-uk
#14
Nicholas Johnson
No abstract text is available yet for this article.
October 8, 2016: Veterinary Record
https://www.readbyqxmd.com/read/27755775/spurious-reticulocyte-profiles-in-a-dog-with-babesiosis
#15
Laetitia Piane, Marie-Laure Théron, Marcel Aumann, Catherine Trumel
A 9-year-old, female Maltese dog was referred to the Veterinary School of Toulouse with a 2-day history of anorexia and weakness. On clinical examination, the dog had hyperthermia (39.7°C), abdominal discomfort, and polypnea. Significant laboratory findings included pigmenturia, hyperbilirubinemia, hypercreatininemia, hyperfibrinogenemia, abnormal Snap canine pancreas-specific lipase, and pancytopenia with a nonregenerative anemia. A peripheral blood smear revealed numerous intraerythrocytic large Babesia but no polychromasia...
October 18, 2016: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/27752055/genome-wide-diversity-and-gene-expression-profiling-of-babesia-microti-isolates-identify-polymorphic-genes-that-mediate-host-pathogen-interactions
#16
Joana C Silva, Emmanuel Cornillot, Carrie McCracken, Sahar Usmani-Brown, Ankit Dwivedi, Olukemi O Ifeonu, Jonathan Crabtree, Hanzel T Gotia, Azan Z Virji, Christelle Reynes, Jacques Colinge, Vidya Kumar, Lauren Lawres, Joseph E Pazzi, Jozelyn V Pablo, Chris Hung, Jana Brancato, Priti Kumari, Joshua Orvis, Kyle Tretina, Marcus Chibucos, Sandy Ott, Lisa Sadzewicz, Naomi Sengamalay, Amol C Shetty, Qi Su, Luke Tallon, Claire M Fraser, Roger Frutos, Douglas M Molina, Peter J Krause, Choukri Ben Mamoun
Babesia microti, a tick-transmitted, intraerythrocytic protozoan parasite circulating mainly among small mammals, is the primary cause of human babesiosis. While most cases are transmitted by Ixodes ticks, the disease may also be transmitted through blood transfusion and perinatally. A comprehensive analysis of genome composition, genetic diversity, and gene expression profiling of seven B. microti isolates revealed that genetic variation in isolates from the Northeast United States is almost exclusively associated with genes encoding the surface proteome and secretome of the parasite...
October 18, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27748232/expression-of-sheep-pathogen-babesia-sp-xinjiang-rhoptry-associated-protein-1-and-evaluation-of-its-diagnostic-potential-by-enzyme-linked-immunosorbent-assay
#17
Qingli Niu, Zhijie Liu, Jifei Yang, Peifa Yu, Yuping Pan, Bintao Zhai, Jianxun Luo, Guiquan Guan, Hong Yin
Ovine babesiosis is one of the most important tick-borne haemoparasitic diseases of small ruminants. The ovine parasite Babesia sp. Xinjiang is widespread in China. In this study, recombinant full-length XJrRAP-1aα2 (rhoptry-associated protein 1aα2) and C-terminal XJrRAP-1aα2 CT of Babesia sp. Xinjiang were expressed and used to evaluate their diagnostic potential for Babesia sp. Xinjiang infections by indirect enzyme-linked immunosorbent assay (ELISA). Purified XJrRAP-1aα2 was tested for reactivity with sera from animals experimentally infected with Babesia sp...
October 17, 2016: Parasitology
https://www.readbyqxmd.com/read/27726821/parasites
#18
Elitza S Theel, Bobbi S Pritt
Parasites are an important cause of human disease worldwide. The clinical severity and outcome of parasitic disease is often dependent on the immune status of the host. Specific parasitic diseases discussed in this chapter are amebiasis, giardiasis, cryptosporidiosis, cyclosporiasis, cystoisosporiasis, microsporidosis, granulomatous amebic encephalitis, toxoplasmosis, leishmaniasis, Chagas disease, malaria, babesiosis, strongyloidiasis, and scabies.
August 2016: Microbiology Spectrum
https://www.readbyqxmd.com/read/27701759/spurious-reticulocyte-profiles-in-dogs-with-large-form-babesiosis-a-retrospective-study
#19
Laetitia Piane, Karen M Young, Lena Giraud, Nathalie Bourges-Abella, Catherine Trumel
BACKGROUND: Erroneously high reticulocyte counts (pseudoreticulocytosis) have been reported in dogs with leukemia. Pseudoreticulocytosis and an abnormal reticulocyte profile were observed in a dog with large form babesiosis presented at our institution. OBJECTIVES: The aims of this retrospective study were to determine if dogs with babesiosis and other dogs had abnormal reticulocyte profiles, and to correlate these profiles with the primary diagnosis. METHODS: All canine CBCs obtained with the Sysmex XT-2000iV or Procyte DX were reviewed...
October 4, 2016: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/27668751/expression-of-6-cys-gene-superfamily-defines-babesia-bovis-sexual-stage-development-within-rhipicephalus-microplus
#20
Heba F Alzan, Audrey O T Lau, Donald P Knowles, David R Herndon, Massaro W Ueti, Glen A Scoles, Lowell S Kappmeyer, Carlos E Suarez
Babesia bovis, an intra-erythrocytic tick-borne apicomplexan protozoan, is one of the causative agents of bovine babesiosis. Its life cycle includes sexual reproduction within cattle fever ticks, Rhipicephalus spp. Six B. bovis 6-Cys gene superfamily members were previously identified (A, B, C, D, E, F) where their orthologues in Plasmodium parasite have been shown to encode for proteins required for the development of sexual stages. The current study identified four additional 6-Cys genes (G, H, I, J) in the B...
2016: PloS One
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