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Babesiosis

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https://www.readbyqxmd.com/read/29666434/stable-transformation-of-babesia-bigemina-and-babesia-bovis-using-a-single-transfection-plasmid
#1
Marta G Silva, Donald P Knowles, Monica L Mazuz, Brian M Cooke, Carlos E Suarez
Babesia bigemina and Babesia bovis, are the two major causes of bovine babesiosis, a global neglected disease in need of improved methods of control. Here, we describe a shared method for the stable transfection of these two parasites using electroporation and blasticidin/blasticidin deaminase as a selectable marker. Stably transfected B. bigemina and B. bovis were obtained using a common transfection plasmid targeting the enhanced green fluorescent protein-BSD (egfp-bsd) fusion gene into the elongation factor-1α (ef-1α) locus of B...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29664114/superior-real-time-polymerase-chain-reaction-detection-of-babesia-microti-parasites-in-whole-blood-utilizing-high-copy-bmn-antigens-as-amplification-targets
#2
Bryan Grabias, Jean Clement, Peter Krause, Timothy Lepore, Sanjai Kumar
BACKGROUND: Babesiosis is a zoonotic disease transmitted to humans by the bite of infected ticks and caused by apicomplexan parasites, most commonly Babesia microti. Additionally, blood and blood products collected from asymptomatically infected blood donors may cause transfusion-transmitted infections in recipients. Highly sensitive molecular assays that detect parasite nucleic acid are needed for laboratory diagnosis and to identify and defer clinically silent but parasitemic blood donors...
April 17, 2018: Transfusion
https://www.readbyqxmd.com/read/29659338/an-improved-pcr-protocol-for-detection-of-babesia-duncani-in-wildlife-and-vector-samples
#3
Kerry E O'Connor, Anne M Kjemtrup, Patricia Ann Conrad, Andrea Swei
Human babesiosis is a tick-borne protozoal disease of increasing clinical significance in North America. Most cases in the eastern and mid-western regions of the United States are reportedly due to Babesia microti infections. By contrast, most human infections reported in California and Washington have been attributed to a new species that was first identified in 1991 and subsequently named Babesia duncani. While the tick vector and mammalian reservoir hosts for B. microti are well characterized, the vector and reservoir hosts for B...
April 16, 2018: Journal of Parasitology
https://www.readbyqxmd.com/read/29657415/semi-nested-polymerase-chain-reaction-based-detection-of-babesia-spp-in-small-ruminants-from-northwest-of-iran
#4
Ahad Bazmani, Amir Abolhooshyar, Abbas Imani-Baran, Hamid Akbari
Aim: The present study aimed to detect Babesia ovis and Babesia motasi in the blood samples of sheep and goats from Northwest of Iran by the semi-nested polymerase chain reaction (PCR) technique. Materials and Methods: A total of 166 whole blood samples (including 123 sheep and 43 goats) were collected. In the first stage, the PCR was performed to amplify a piece of 18S rRNA gene of Babesia and Theileria genera. Then, semi-nested PCR was carried out on all PCR products to differentiate B...
March 2018: Veterinary World
https://www.readbyqxmd.com/read/29657012/antiprotozoal-treatment-of-canine-babesiosis
#5
Gad Baneth
Canine babesiosis is a tick-borne disease caused by several Babesia spp. which have different susceptebility to anti-protozoal drugs. A few drugs and drug combinations are used in the treatment of canine babesiosis often without complete parasite elimination leaving treated dogs as carriers which could relapse with clinical disease and also transmit infection further. Although the large form canine babesial species Babesia canis, Babesia vogeli and Babesia rossi are sensitive to the aromatic diamidines imidocarb dipropionate and diminazene aceturate, small form species such as Babesia gibsoni, Babesia conradae and Babesia vulpes (Theileria annae) are relatively resistant to these drugs and are treated with the combination of the hydroxynaphthoquinone atovaquone and the antibiotic azithromycin...
April 30, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29642942/molecular-identification-of-badger-associated-babesia-sp-dna-in-dogs-updated-phylogeny-of-piroplasms-infecting-caniformia
#6
Sándor Hornok, Gábor Horváth, Nóra Takács, Jenő Kontschán, Krisztina Szőke, Róbert Farkas
BACKGROUND: Piroplasms are unicellular, tick-borne parasites. Among them, during the past decade, an increasing diversity of Babesia spp. has been reported from wild carnivores. On the other hand, despite the known contact of domestic and wild carnivores (e.g. during hunting), and a number of ixodid tick species they share, data on the infection of dogs with babesiae from other families of carnivores are rare. METHODS: In this study blood samples were collected from 90 dogs and five road-killed badgers...
April 11, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29625920/simultaneous-detection-of-theileria-annulata-and-theileria-orientalis-infections-using-recombinase-polymerase-amplification
#7
Muhammad Adeel Hassan, Junlong Liu, Muhammad Sohail Sajid, Muhammad Rashid, Altaf Mahmood, Qamar Abbas, Guiquan Guan, Hong Yin, Jianxun Luo
Theileriosis is a disease of domesticated animals in tropical and subtropical countries and causes significant reductions in livestock productivity. The arid region of Punjab in Pakistan is notorious for the presence of the vector tick (Acari: Ixodidae) and tick-borne diseases, such as theileriosis and babesiosis. The distribution of Theileria annulata and T. orientalis in the Chakwal district of Punjab was determined by developing a multiplex recombinase polymerase amplification (RPA) assay as a scientific basis for formulating control strategies for bovine theileriosis...
March 28, 2018: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29604992/first-description-of-the-pathogenicity-of-babesia-vogeli-in-experimentally-infected-dogs
#8
Jiawei Wang, Jilei Zhang, Patrick Kelly, Xiaofeng Zheng, Min Li, Jinfeng You, Ke Huang, Haixiang Qiu, Yaoyao Wang, Rong Zhang, Jianji Li, Junsheng Dong, Yi Feng, Jinlin Zhou, Chengming Wang
Babesiosis is a tick-borne disease that occurs worldwide with the most recognized Babesia species that infect dogs being Babesia canis, B. vogeli, B. rossi and B. gibsoni. While B. vogeli is reported in dogs worldwide, clinical and laboratory data on infections is based on reports of naturally infected dogs. To provide reliable data on the clinical and laboratory abnormalities associated with acute and more chronic infections in healthy dogs free of other tick-borne diseases, we experimentally infected dogs with a Chinese strain of B...
April 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29582438/a-pilot-serosurvey-of-babesia-microti-in-chinese-blood-donors
#9
E M Bloch, Y Yang, M He, L Tonnetti, Y Liu, J Wang, Y Guo, H Li, D A Leiby, H Shan
BACKGROUND AND OBJECTIVES: Babesia spp. are tick-borne, intraerythrocytic protozoan parasites, several of which are transfusion-transmissible. Transfusion-transmitted babesiosis poses serious risk to a diverse patient population, including neonates, patients aged >50 years, the asplenic and the immunocompromised that are over-represented among transfusion recipients. Despite reports of B. microti and B. venatorum in People's Republic of China (PRC), no surveillance of blood donors for Babesia has previously been undertaken...
March 26, 2018: Vox Sanguinis
https://www.readbyqxmd.com/read/29570655/population-dynamics-of-off-host-rhipicephalus-boophilus-microplus-acari-ixodidae-larvae-in-response-to-habitat-and-seasonality-in-south-texas
#10
Brenda Leal, Donald B Thomas, Robert K Dearth
The cattle tick, Rhipicephalus microplus (Canestrini), is an economically destructive arthropod because of its ability to vector bovine babesiosis. It is known that cattle ticks can spend 80-90% of their lifecycle as questing larvae, yet the effect of climatic factors on their off-host behavior and survival is unclear. The goal of this study was to measure the effects of specific ecological factors on off-host questing larvae in nature. The study was conducted in a south Texas pasture over a two-year period, during which time larval populations were surveyed...
March 23, 2018: Veterinary Sciences
https://www.readbyqxmd.com/read/29570654/immunomolecular-characterization-of-mic-1-a-novel-antigen-in-babesia-bigemina-which-contains-conserved-and-immunodominant-b-cell-epitopes-that-induce-neutralizing-antibodies
#11
Diego Josimar Hernández-Silva, Uriel Mauricio Valdez-Espinoza, Miguel Angel Mercado-Uriostegui, Gabriela Aguilar-Tipacamú, Juan Alberto Ramos-Aragón, Ruben Hernández-Ortiz, Massaro Ueti, Juan Mosqueda
Babesia bigemina is one of the most prevalent species causing bovine babesiosis around the world. Antigens involved in host cell invasion are vaccine targets for this disease but are largely unknown in this species. The invasion process of Babesia spp. into erythrocytes involves membrane proteins from the apical complex. A protein stored in the micronemes, called Micronemal Protein 1 (MIC-1), contains a sialic acid binding domain that participates in the invasion process of host cells and is a vaccine candidate in other apicomplexan parasites...
March 23, 2018: Veterinary Sciences
https://www.readbyqxmd.com/read/29567936/splenic-rupture-as-the-first-manifestation-of-babesia-microti-infection-report-of-a-case-and-review-of-literature
#12
Igor Dumic, Janki Patel, Melissa Hart, Eric R Niendorf, Scott Martin, Poornima Ramanan
BACKGROUND Babesiosis is an emerging, tick-borne zoonosis caused by intraerythrocytic protozoa of the genus Babesia. Babesia microti is the main pathogen causing human disease and is endemic in the northeastern and upper midwestern parts of the USA. Severity of infection ranges from mild, self-limited, febrile viral-like illness accompanied by nonspecific symptoms to life-threatening infection complicated by severe hemolytic anemia, disseminated intravascular coagulation (DIC), acute respiratory distress syndrome (ARDS), and renal or/and hepatic failure...
March 23, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29565993/zoonotic-babesia-microti-in-the-northeastern-u-s-evidence-for-the-expansion-of-a-specific-parasite-lineage
#13
Heidi K Goethert, Philip Molloy, Victor Berardi, Karen Weeks, Sam R Telford
The recent range expansion of human babesiosis in the northeastern United States, once found only in restricted coastal sites, is not well understood. This study sought to utilize a large number of samples to examine the population structure of the parasites on a fine scale to provide insights into the mode of emergence across the region. 228 B. microti samples collected in endemic northeastern U.S. sites were genotyped using published Variable number tandem repeat (VNTR) markers. The genetic diversity and population structure were analysed on a geographic scale using Phyloviz and TESS, programs that utilize two different methods to identify population membership without predefined population data...
2018: PloS One
https://www.readbyqxmd.com/read/29559329/molecular-characterization-of-babesia-microti-seroreactive-antigen-5-1-1-and-development-of-rapid-detection-methods-for-anti-b-microti-antibodies-in-serum
#14
Yu Chun Cai, Fen Wu, Wei Hu, Jiaxu Chen, Shao Hong Chen, Bin Xu, Yan Lu, Lin Ai, Chun Li Yang, Shimin Zhao
Babesiosis has become a new global threat impacting human health, and most human babesiosis cases are caused by Babesia microti. Until now few antigens of B. microti have been described which can be used for the diagnosis of human babesiosis. In the present study, we report on the bioinformatic analysis, cloning and expression of the sequence encoding the B. microti seroreactive antigen 5-1-1 to investigate its potential incorporation in serologic diagnostic tools for babesiosis. Bioinformatic analysis and recombinant gene expression were performed to molecularly characterize seroreactive antigen 5-1-1...
March 17, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29559137/haemoparasitic-agents-associated-with-ovine-babesiosis-a-possible-negative-interaction-between-babesia-ovis-and-theileria-ovis
#15
Ferda Sevinc, Mo Zhou, Shinuo Cao, Onur Ceylan, Mehmet Fatih Aydin, Mutlu Sevinc, Xuenan Xuan
Babesiosis, theileriosis, and anaplasmosis are the most common tick-borne diseases in sheep. The majority of anaplasmosis and theileriosis are subclinical; however, babesiosis causes severe infections in small ruminants. Although there are many reports of co-infections with the agents of these diseases, their clinical severity compared with either of the infections alone is unknown. Within the host, interactions between co-infecting species may cause variations in clinical presentation and response to therapy...
March 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29558984/endemic-exotic-and-novel-apicomplexan-parasites-detected-during-a-national-study-of-ticks-from-companion-animals-in-australia
#16
Telleasha L Greay, Alireza Zahedi, Anna-Sheree Krige, Jadyn M Owens, Robert L Rees, Una M Ryan, Charlotte L Oskam, Peter J Irwin
BACKGROUND: Apicomplexan tick-borne pathogens that cause disease in companion animals include species of Babesia Starcovici, 1893, Cytauxzoon Neitz & Thomas, 1948, Hepatozoon Miller, 1908 and Theileria Bettencourt, Franca & Borges, 1907. The only apicomplexan tick-borne disease of companion animals that is known to occur in Australia is babesiosis, caused by Babesia canis vogeli Reichenow, 1937 and Babesia gibsoni Patton, 1910. However, no molecular investigations have widely investigated members of Apicomplexa Levine, 1980 in Australian ticks that parasitise dogs, cats or horses, until this present investigation...
March 20, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29558219/azotemia-and-proteinuria-in-dogs-infected-with-babesia-gibsoni
#17
Tarini Ullal, Adam Birkenheuer, Shelly Vaden
Babesiosis is a hemoprotozoal tick-borne disease that is commonly associated with thrombocytopenia and anemia; however, renal involvement has been documented in dogs. The purpose of this retrospective study was to document azotemia and proteinuria in dogs infected with Babesia sp. and to describe the response to antiprotozoal therapy. The electronic database of the North Carolina State University Vector Borne Disease Laboratory was searched to identify dogs who were diagnosed with babesiosis and to determine if they had proteinuria and/or azotemia...
March 20, 2018: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/29554924/molecular-evidence-for-the-transovarial-passage-of-babesia-gibsoni-in-haemaphysalis-hystricis-acari-ixodidae-ticks-from-taiwan-a-novel-vector-for-canine-babesiosis
#18
Frans Jongejan, Bi-Ling Su, Hsiang-Ju Yang, Laura Berger, Judith Bevers, Pin-Chen Liu, Jou-Chien Fang, Ya-Wen Cheng, Charlotte Kraakman, Nadine Plaxton
BACKGROUND: Babesia gibsoni is the predominant tick-borne protozoan blood parasite affecting dogs throughout the Oriental region. Babesia gibsoni is transmitted by Haemaphysalis longicornis, whereas a similar role has been suggested for Rhipicephalus sanguineus. Haemaphysalis longicornis does not occur in Taiwan, but R. sanguineus is widely distributed on dogs. However, clinical cases of babesiosis are mainly restricted to the northern part of the island. The discrepancy between tick distribution and clinical cases stimulated us to investigate the tick species distribution on dogs in northern Taiwan, with the aim to identify the local vector for canine babesiosis...
March 20, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29538646/human-babesiosis-caused-by-a-babesia-crassa-like-pathogen-a-case-series
#19
Na Jia, Yuan-Chun Zheng, Jia-Fu Jiang, Rui-Ruo Jiang, Bao-Gui Jiang, Ran Wei, Hong-Bo Liu, Qiu-Bo Huo, Yi Sun, Yan-Li Chu, Hang Fan, Qiao-Cheng Chang, Nan-Nan Yao, Wen-Hui Zhang, Hong Wang, Dong-Hui Guo, Xue Fu, Ya-Wei Wang, Peter J Krause, Ju-Liang Song, Wu-Chun Cao
Background: Human babesiosis is an emerging health problem in China. Methods: Babesia were identified in ticks, sheep, and humans in northeastern China using PCR followed by genetic sequencing. We enrolled residents of Heilongjiang and Jilin provinces between 2015 and 2016 who reported a recent tick bite and experienced a viral like illness after recent tick bite or were healthy residents. We evaluated them for Babesia infection using history; physical examination; and blood smear, PCR, and genetic sequencing...
March 10, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29528151/community-acquired-and-transfusion-transmitted-babesiosis-are-increasing-why-and-what-to-do
#20
EDITORIAL
Sanjai Kumar, Durland Fish, Peter J Krause
No abstract text is available yet for this article.
March 2018: Transfusion
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