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https://www.readbyqxmd.com/read/29469340/-research-progress-of-babesia-rhoptry-associated-proteins
#1
Yang Chun-Li, Cai Yu-Chun, Chen Jia-Xu
Babesia parasites are obligate intracellular apicomplexan protozoa and important pathogens causing babesiosis of humans and animals. They have conserved subcellular structures and invasion mechanism. Rhoptry-associated proteins, which are released into the host cell, are considered to be the key molecules of invasion and replication of parasites in the host cell and are immunosuppressive factors of the host cell mediated immunity in the stage of parasitophorous vacuole (PV) formation. The knowledge about rhoptry-associated proteins has made a great progress with the development of genomics and proteomics, so we review the research progress in rhoptry-associated proteins of different Babesia including Babesia bovis , B...
March 22, 2017: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
https://www.readbyqxmd.com/read/29453420/a-multiplex-serologic-platform-for-diagnosis-of-tick-borne-diseases
#2
Rafal Tokarz, Nischay Mishra, Teresa Tagliafierro, Stephen Sameroff, Adrian Caciula, Lokendrasingh Chauhan, Jigar Patel, Eric Sullivan, Azad Gucwa, Brian Fallon, Marc Golightly, Claudia Molins, Martin Schriefer, Adriana Marques, Thomas Briese, W Ian Lipkin
Tick-borne diseases are the most common vector-borne diseases in the United States, with serology being the primary method of diagnosis. We developed the first multiplex, array-based assay for serodiagnosis of tick-borne diseases called the TBD-Serochip. The TBD-Serochip was designed to discriminate antibody responses to 8 major tick-borne pathogens present in the United States, including Anaplasma phagocytophilum, Babesia microti, Borrelia burgdorferi, Borrelia miyamotoi, Ehrlichia chaffeensis, Rickettsia rickettsii, Heartland virus and Powassan virus...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29445365/-babesia-microti-infection-changes-host-spleen-architecture-and-is-cleared-by-a-th1-immune-response
#3
Vitomir Djokic, Lavoisier Akoolo, Nikhat Parveen
Babesia microti is a malaria-like parasite, which infects ∼2000 people annually, such that babesiosis is now a notifiable disease in the United States. Immunocompetent individuals often remain asymptomatic and are tested only after they feel ill. Susceptible C3H/HeJ mice show several human-like disease manifestations and are ideal to study pathogenesis of Babesia species. In this study, we examined parasitemia of B. microti at different time points and assessed its impact on hemoglobin levels in blood, on spleen pathology and overall immune response in C3H/HeJ mice...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29430231/babesiosis-presenting-as-acute-liver-failure
#4
Yousef Nassar, Seth Richter
Babesiosis is a zoonotic, tick-borne infection caused by the protozoan Babesia . It is transmitted by the Ixodes ticks which transmit the infection to humans. Babesia microti , Babesia duncani , Babesia divergens , and Babesia venatorum are species that have been identified as being infectious to humans worldwide. The most common species causing infection to humans is B. microti which is endemic to the Northeast and Midwestern United States with most infections occurring between the months of May and October...
September 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/29415034/molecular-characterization-of-the-recombinant-protein-rmlti-bmcg-ltb-protective-immunity-against-rhipicephalus-boophilus-microplus
#5
Bárbara Guimarães Csordas, Rodrigo Casquero Cunha, Marcos Valério Garcia, Sérgio Silva da Silva, Fábio Leivas Leite, Renato Andreotti
The bovine tick Rhipicephalus (Boophilus) microplus is found in several tropical and subtropical regions of the world. This parasite transmits pathogens that cause disease, such as babesiosis (Babesia bovis and B. bigemina) and anaplasmosis (Anaplasma marginale). Tick infestations cause enormous livestock losses, and controlling tick infestations and the transmission of tick-borne diseases remains a challenge for the livestock industry. Because the currently available commercial vaccines offer only partial protection against R...
2018: PloS One
https://www.readbyqxmd.com/read/29398603/pathogen-transmission-in-relation-to-duration-of-attachment-by-ixodes-scapularis-ticks
#6
REVIEW
Lars Eisen
The blacklegged tick, Ixodes scapularis, is the primary vector to humans in the eastern United States of the deer tick virus lineage of Powassan virus (Powassan virus disease); the protozoan parasite Babesia microti (babesiosis); and multiple bacterial disease agents including Anaplasma phagocytophilum (anaplasmosis), Borrelia burgdorferi and Borrelia mayonii (Lyme disease), Borrelia miyamotoi (relapsing fever-like illness, named Borrelia miyamotoi disease), and Ehrlichia muris eauclairensis (a minor causative agent of ehrlichiosis)...
January 31, 2018: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29394381/case-report-of-the-patient-source-of-the-babesia-microti-r1-reference-strain-and-implications-for-travelers
#7
Philipp Stahl, Yves Poinsignon, Pascal Pouedras, Vasilica Ciubotaru, Laurence Berry, Brinda Emu, Peter J Krause, Choukri Ben Mamoun, Emmanuel Cornillot
Background: In 2002, a previously healthy 69-year-old man travelled to France from the United States and presented to our hospital with a febrile illness that subsequently was determined to be babesiosis. The blood isolated from this patient served as a source for propagation of the Babesia microti R1 strain with subsequent sequencing and annotation of the parasite genome. Methods: Upon admission, we obtained a medical history, performed a physical examination, and examined his blood for the presence of a blood borne pathogen by microscopy, PCR and indirect immunofluorescence antibody testing...
January 1, 2018: Journal of Travel Medicine
https://www.readbyqxmd.com/read/29383735/transfusion-transmitted-and-community-acquired-babesiosis-in-new-york-2004-to-2015
#8
Jeanne V Linden, Melissa A Prusinski, Lauren A Crowder, Laura Tonnetti, Susan L Stramer, Debra A Kessler, Jennifer White, Beth Shaz, Danuta Olkowska
BACKGROUND: Babesiosis is a potentially life-threatening zoonotic infection most frequently caused by the intraerythrocytic parasite Babesia microti. The pathogen is usually tickborne, but may also be transfusion or vertically transmitted. Healthy persons, including blood donors, may be asymptomatic and unaware they are infected. Immunocompromised patients are at increased risk for symptomatic disease. STUDY DESIGN AND METHODS: All reported community-acquired babesiosis cases in New York from 2004 to 2015 were evaluated, enumerated, and characterized...
January 31, 2018: Transfusion
https://www.readbyqxmd.com/read/29360801/development-of-an-indirect-elisa-based-on-a-recombinant-chimeric-protein-for-the-detection-of-antibodies-against-bovine-babesiosis
#9
José Manuel Jaramillo Ortiz, Valeria Noely Montenegro, Sofía Ana María de la Fournière, Néstor Fabián Sarmiento, Marisa Diana Farber, Silvina Elizabeth Wilkowsky
The current method for Babesia spp. serodiagnosis based on a crude merozoite antigen is a complex and time-consuming procedure. An indirect enzyme-linked immunosorbent assay (iELISA) based on a recombinant multi-antigen of Babesia bovis (rMABbO) was developed for detection of antibodies in bovines suspected of infection with this parasite. The multi-antigen comprises gene fragments of three previously characterized B. bovis antigens: MSA-2c, RAP-1 and the Heat Shock protein 20 that are well-conserved among geographically distant strains...
January 23, 2018: Veterinary Sciences
https://www.readbyqxmd.com/read/29355731/human-babesiosis-in-southeast-china-a-case-report
#10
Shanshan Huang, Lingling Zhang, Linong Yao, Jie Li, Hui Chen, Qingxiang Ni, Chenwei Pan, Lingxiang Jin
A 60-year-old female patient living in southeastern China presented with persistent fever, chills, night sweats, fatigue and dizziness for 12 days. Blood tests showed neutropenia, thrombocytopenia and active hemolytic anemia with elevated C-reactive protein. Broad spectrum antibiotics for a possible diagnosis of sepsis were administered without any response. Malaria was diagnosed initially after visualizing intraerythrocytic ring shaped parasites in bone marrow and blood smears. The region the patient lived in was an area of unstable endemicity for Plasmodium falciparum...
January 17, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29343275/early-babesia-canis-transmission-in-dogs-within-24%C3%A2-h-and-8%C3%A2-h-of-infestation-with-infected-pre-activated-male-dermacentor-reticulatus-ticks
#11
Marie Varloud, Julian Liebenberg, Josephus Fourie
BACKGROUND: This study was designed to assess the ability of fed male Dermacentor reticulatus ticks to transmit Babesia canis to dogs after being detached from previous canine or ovine hosts. METHODS: The study was an exploratory, parallel group design conducted in two trials. All the animals were sero-negative for babesiosis prior to enrolment. In a first trial, donor dogs and donor sheep were infested with Babesia canis infected male and uninfected female ticks for 72 h...
January 17, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29336985/the-blacklegged-tick-ixodes-scapularis-an-increasing-public-health-concern
#12
REVIEW
Rebecca J Eisen, Lars Eisen
In the United States, the blacklegged tick, Ixodes scapularis, is a vector of seven human pathogens, including those causing Lyme disease, anaplasmosis, babesiosis, Borrelia miyamotoi disease, Powassan virus disease, and ehrlichiosis associated with Ehrlichia muris eauclarensis. In addition to an accelerated rate of discovery of I. scapularis-borne pathogens over the past two decades, the geographic range of the tick, and incidence and range of I. scapularis-borne disease cases, have increased. Despite knowledge of when and where humans are most at risk of exposure to infected ticks, control of I...
January 11, 2018: Trends in Parasitology
https://www.readbyqxmd.com/read/29335000/molecular-characterization-of-babesia-microti-thioredoxin-bmtrx2-and-its-expression-patterns-induced-by-antiprotozoal-drugs
#13
Jingwei Huang, Kang Xiong, Houshuang Zhang, Yanzhen Zhao, Jie Cao, Haiyan Gong, Yongzhi Zhou, Jinlin Zhou
BACKGROUND: Human babesiosis is an infectious disease that is epidemic in various regions all over the world. The predominant causative pathogen of this disease is the intra-erythrocytic parasite Babesia microti. The thioredoxin system is one of the major weapons that is used in the resistance to the reactive oxygen species (ROS) and reactive nitrogen species (RNS) produced by host immune system. In other intra-erythrocytic apicomplexans like the malaria parasite Plasmodium falciparum, anti-oxidative proteins are promising targets for the development of anti-parasitic drugs...
January 15, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29331578/molecular-detection-and-characterisation-of-babesia-and-theileria-in-australian-hard-ticks
#14
Brooke Storey-Lewis, Ann Mitrovic, Brent McParland
Babesia and Theileria are intraerythrocytic protozoans of the phylum Apicomplexa. These species are capable of infecting wild and domestic animals and have historically caused great economic loss in the agricultural industry. In recent years human babesiosis has been deemed an emerging zoonosis in North America, Europe and Asia. The first locally acquired case of babesiosis in Australia, caused by Babesia microti, was reported in March 2012. A number of native Babesia and Theileria species have been identified in Australian marsupials, however their associated tick vectors and threat to human health is unknown...
December 24, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29304171/mcp-1-kc-like-and-il-8-as-critical-mediators-of-pathogenesis-caused-by-babesia-canis
#15
Asier Galán, Iva Mayer, Renata Barić Rafaj, Krešo Bendelja, Velimir Sušić, José Joaquín Cerón, Vladimir Mrljak
Canine babesiosis caused by the intraerythrocytic protozoan parasite Babesia canis is a tick-borne disease characterized by a host response that involves both cellular and humoral immunity. This study focuses on the secretion of cytokines Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF), Keratinocyte Chemotactic-like (KC-like), Interleukins (IL)-2, IL-7, IL-8, IL-10, IL-15, IL-18 and Monocyte Chemotactic Protein-1 (MCP-1) in babesiosis caused by Babesia canis upon treatment with Imizol®. We assessed time dependent changes in cytokine levels and tested whether these changes correlate with pathogenesis of the disease...
2018: PloS One
https://www.readbyqxmd.com/read/29302103/babesia-odocoilei-as-a-cause-of-mortality-in-captive-cervids-in-canada
#16
Amélie Mathieu, Adriana R Pastor, Charlene N Berkvens, Carolyn Gara-Boivin, Michel Hébert, Alexandre N Léveillé, John R Barta, Dale A Smith
Nine cases of fatal infection with Babesia odocoilei were confirmed in reindeer (Rangifer tarandus tarandus) and elk (Cervus canadensis) housed in zoological institutions located in southern Quebec, Ontario, and Manitoba, Canada between 2013 and 2016. All animals died of a hemolytic crisis. Frequent postmortem findings were extensive hemorrhage, pigmenturia, and intrahepatic cholestasis. The described ante- and postmortem signs are consistent with those of previously reported cases in the United States. Diagnosis was confirmed in all cases by polymerase chain reaction performed on DNA extracted from whole blood or frozen spleen...
January 2018: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/29290581/first-molecular-detection-of-babesia-canis-in-dogs-from-bosnia-and-herzegovina
#17
Agnesa Ćoralić, Simona Gabrielli, Amir Zahirović, Nikola M Stojanović, Giovanni Luigi Milardi, Adnan Jažić, Almedina Zuko, Denis Čamo, Suzana Otašević
Babesia spp. are tick-transmitted protozoan haemoparasites of great economic, veterinary and medical impact worldwide. Herein we reported the very high prevalence of autochthonous babesiosis in symptomatic dogs from Bosnia and Herzegovina in the period from 2014 to 2016. Eighty dogs that did not leave the country were examined using parasitological and molecular analyses and babesiosis was diagnosed in 82.5% and 85.0% of them, respectively (p < 0.001). One species, Babesia canis was identified using molecular methodology (PCR and sequence analysis)...
December 24, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29277955/tick-borne-illness-after-transplantation-case-and-review
#18
Tresa Reena Mascarenhas, Randi S Silibovsky, Pooja Singh, Katherine Belden
Tick-borne infections in solid organ transplant recipients are an infrequent and difficult diagnostic challenge owing to multiple routes of acquisition and unusual presentations. A 67-year-old male recipient of a combined liver and kidney transplant presented with recurrent fevers following surgery. Standard microbiologic workup was non-diagnostic. Shortness of breath, confusion, lethargy, and hypotension developed along with progressive anemia, requiring multiple blood transfusions. Workup suggested hemolysis and review of the peripheral smear was diagnostic for Babesia microti infection...
December 26, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29274217/evaluation-of-inhibitory-effect-of-redox-active-antimalarial-drug-against-babesia-microti-in-mice
#19
Joanna Szymczak, Julia Kozłowska, Maria Doligalska
Babesiosis is an emerging, tick-transmitted disease caused by the intraerythrocytic parasite Babesia microti. In immunocompetent individuals, B. microti infection quickly resolves after antibabesial treatment. Immunocompromised patients and those of advanced age experience chronic and relapsing babesiosis, accompanied by severe complications and often, a fatal outcome. In these individuals, B. microti infection may persist despite multiple courses of treatment with antiprotozoal drugs. The increasing incidence of human babesiosis caused by B...
2017: Annals of Parasitology
https://www.readbyqxmd.com/read/29258802/a-molecular-algorithm-to-detect-and-differentiate-human-pathogens-infecting-ixodes-scapularis-and-ixodes-pacificus-acari-ixodidae
#20
Christine B Graham, Sarah E Maes, Andrias Hojgaard, Amy C Fleshman, Sarah W Sheldon, Rebecca J Eisen
The incidence and geographic range of tick-borne illness associated with Ixodes scapularis and Ixodes pacificus have dramatically increased in recent decades. Anaplasmosis, babesiosis, and Borrelia spirochete infections, including Lyme borreliosis, account for tens of thousands of reported cases of tick-borne disease every year. Assays that reliably detect pathogens in ticks allow investigators and public health agencies to estimate the geographic distribution of human pathogens, assess geographic variation in their prevalence, and evaluate the effectiveness of prevention strategies...
December 10, 2017: Ticks and Tick-borne Diseases
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