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Babesiosis

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https://www.readbyqxmd.com/read/28807287/an-elisa-for-the-early-diagnosis-of-acute-canine-babesiosis-detecting-circulating-antigen-of-large-babesia-spp
#1
Ramon M Eichenberger, Saša Štefanić, Torsten J Naucke, Mindaugas Šarkūnas, Gintaras Zamokas, Felix Grimm, Peter Deplazes
Babesia canis is the predominant Babesia species in dogs in Europe and is responsible for a severe and fatal disease. An increase in global pet tourism and a widening of the geographic distribution of the tick vector has led to the emergence of infections in areas where previously only imported cases have been reported. Due to the potential for rapid and serious disease progression, direct parasite detection by stained blood smears and light microscopy or DNA-based methods have traditionally been used for the diagnosis of acute infections...
August 30, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28803569/detection-of-kobe-type-and-otsu-type-babesia-microti-in-wild-rodents-in-china-s-yunnan-province
#2
Xin-Rong Chen, L I Ye, Jun-Wen Fan, Chang Li, Fang Tang, Wei Liu, Lin-Zhu Ren, Jie-Ying Bai
Babesiosis is an emerging tick-transmitted zoonosis prevalent in large parts of the world. This study was designed to determine the rates of Babesia microti infection among small rodents in Yunnan province, where human cases of babesiosis have been reported. Currently, distribution of Babesia in its endemic regions is largely unknown. In this study, we cataloged 1672 small wild rodents, comprising 4 orders, from nine areas in western Yunnan province between 2009 and 2011. Babesia microti DNA was detected by polymerase chain reaction in 4·3% (72/1672) of the rodents analyzed...
August 14, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28799498/structure-based-approaches-targeting-parasite-cysteine-proteases
#3
Rafael Pinto Vieira, Viviane Corrêa Santos, Rafaela Salgado Ferreira
Cysteine proteases are essential hydrolytic enzymes present in the majority of organisms, including viruses and unicellular parasites. Despite the high sequence identity displayed among these proteins, specific structural features across different species grant distinct functions to these biomolecules, frequently related to pathological conditions. Consequently, their relevance as promising targets for potential specific inhibitors has been highlighted and occasionally validated in recent decades. In this review, we discuss the recent outcomes on structure-based campaigns aiming the discovery of new inhibitor prototypes against cruzain and falcipain, as alternative therapeutic tools for Chagas disease and malaria treatments, respectively...
August 10, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28782120/cases-of-transfusion-transmitted-babesiosis-occurring-in-nonendemic-areas-a-diagnostic-dilemma
#4
David P LeBel, Erin D Moritz, Jennifer J O'Brien, John Lazarchick, Lee Marie Tormos, Angie Duong, Magali J Fontaine, Jerry E Squires, Susan L Stramer
BACKGROUND: Transfusion-transmitted babesiosis (TTB) has been rapidly increasing in incidence since the beginning of the 21st century. Asymptomatic individuals with Babesia infection are able to donate blood in the United States because of the lack of specific blood donation testing. Blood products collected in Babesia-endemic areas are distributed nationally; thus, clinicians in nonendemic states may fail to include babesiosis in the differential diagnosis of a patient who had a recent transfusion history and a fever of unknown origin...
August 7, 2017: Transfusion
https://www.readbyqxmd.com/read/28769894/a-historical-overview-of-research-on-babesia-orientalis-a-protozoan-parasite-infecting-water-buffalo
#5
REVIEW
Lan He, Qin Liu, Baoan Yao, Yanqin Zhou, Min Hu, Rui Fang, Junlong Zhao
Babesiosis is a globally important zoonotic disease caused by tick-borne intraerythrocytic protozoan of the genus Babesia (phylum apicomplexa). In China, there are five species that infect cattle buffalo and cause great economic loss, which include Babesia bigemina, B. bovis, B. major, B. ovata, and B. orientalis. Among them, B. orientalis is the most recently identified new Babesia species epidemic in China. This review summarized the work done in the past 33 years to give an overview of what learned about this parasite...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28766838/transfusion-transmitted-babesiosis-leading-to-severe-hemolysis-in-two-patients-with-sickle-cell-anemia
#6
Kristine Karkoska, James Louie, Abena O Appiah-Kubi, Lawrence Wolfe, Lorry Rubin, Sujatha Rajan, Banu Aygun
The intracellular parasites Babesia microti and Babesia duncani can be transmitted by blood transfusion and cause severe life-threatening hemolytic anemia in high-risk patients, including those with sickle cell disease. The rarity of the diagnosis, as well as its similar clinical presentation to delayed hemolytic transfusion reaction, may lead to a delay in diagnosis, as well as inappropriate treatment with steroids or other immunosuppressive agents. The morbidity caused by this disease in especially vulnerable populations justifies the need for a universal blood-screening program in endemic areas...
August 2, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28754599/bioassays-to-evaluate-non-contact-spatial-repellency-contact-irritancy-and-acute-toxicity-of-permethrin-treated-clothing-against-nymphal-ixodes-scapularis-ticks
#7
Lars Eisen, Dominic Rose, Robert Prose, Nicole E Breuner, Marc C Dolan, Karen Thompson, Neeta Connally
Summer-weight clothing articles impregnated with permethrin are available as a personal protective measure against human-biting ticks in the United States. However, very few studies have addressed the impact of contact with summer-weight permethrin-treated textiles on tick vigor and behavior. Our aim was to generate new knowledge of how permethrin-treated textiles impact nymphal Ixodes scapularis ticks, the primary vectors in the eastern United States of the causative agents of Lyme disease, human anaplasmosis, and human babesiosis...
July 1, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/28750862/alteration-of-haemostatic-parameters-in-uncomplicated-canine-babesiosis
#8
Josipa Kuleš, Jelena Gotić, Vladimir Mrljak, Renata Barić Rafaj
Babesiosis is a tick-borne zoonotic disease caused by haemoprotozoan parasites. The aim of this study were to assess markers of coagulation pathways in 25 dogs with naturally occurring babesiosis caused by B. canis, compared to 10 healthy controls. Protein C (PC) and antithrombin III (AT III) activity were assessed using a chromogenic substrate test, while levels of thrombin-antithrombin (TAT) complexes, activated protein C (APC) and endothelial protein C receptor were assessed using canine-specific ELISA. AT III activity was decreased as a result of a negative acute phase response, degradation by elastase, reduced availability of glycosaminoglycans, and, most importantly, consumption as a consequence of thrombin formation...
August 2017: Comparative Immunology, Microbiology and Infectious Diseases
https://www.readbyqxmd.com/read/28747374/babesia-microti-from-mice-to-ticks-to-an-increasing-number-of-highly-susceptible-humans
#9
Lars F Westblade, Matthew S Simon, Blaine A Mathison, Laura A Kirkman
Babesia microti, a zoonotic intraerythrocytic parasite, is the primary etiological agent of human babesiosis in the United States (US). Human infection ranges from subclinical illness to severe disease resulting in death, with symptoms related to host immune status. Despite advances in our understanding and management of B. microti, incidence of infection has increased in the US. Therefore, research focused on eradicating disease and optimizing clinical management is essential. Herein, we review this remarkable organism with emphasis on the clinical, diagnostic, and therapeutic aspects of human disease...
July 26, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28743470/molecular-identification-and-antigenic-characterization-of-babesia-divergens-erythrocyte-binding-protein-bdebp-as-a-potential-vaccine-candidate
#10
Shimaa Abd El-Salam El-Sayed, Mohamed Abdo Rizk, Mohamad Alaa Terkawi, Naoaki Yokoyama, Ikuo Igarashi
Host cell invasion is the only step where Babesia parasites are extracellular, and their survival is menaced during this step. Therefore, interfering with this critical stage is a target for an anti-Babesia intervention strategy. In this regard, recombinant protein encoding Babesia divergens Erythrocyte Binding Protein (BdEBP) was produced in Escherichia coli in the current study, and its antiserum was prepared in mice for further molecular characterization. Western blotting and indirect fluorescent antibody test (IFAT) revealed the specific reaction of the anti-rBdEBP serum with a corresponding authentic protein of B...
July 22, 2017: Parasitology International
https://www.readbyqxmd.com/read/28739301/a-new-pcr-assay-for-the-detection-and-differentiation-of-babesia-canis-and-babesia-vogeli
#11
Giada Annoscia, Maria Stefania Latrofa, Cinzia Cantacessi, Emanuela Olivieri, Maria Teresa Manfredi, Filipe Dantas-Torres, Domenico Otranto
Babesia spp. are globally distributed tick-borne protozoan parasites that infect the red blood cells of a wide range of vertebrate hosts, including humans. Diagnosis of babesiosis is often impeded by the transient presence of the parasites in peripheral blood, as well as by their pleomorphic nature. Given the reports of an expanding and, in some cases, sympatric geographical distribution of Babesia canis and Babesia vogeli in dogs and associated vectors, in Europe, the development of time-efficient and cost-effective diagnostic tools to detect and differentiate these two species is warranted...
July 8, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/28722598/risk-factors-for-severe-infection-hospitalization-and-prolonged-antimicrobial-therapy-in-patients-with-babesiosis
#12
Neeharik Mareedu, Anna M Schotthoefer, Jason Tompkins, Matthew C Hall, Thomas R Fritsche, Holly M Frost
Babesiosis is an emerging tick-borne disease transmitted by the hard tick Ixodes scapularis, which also transmits Lyme disease. Better gradation of prognostic indicators are needed to determine which patients may develop serious complications requiring hospitalization, and to provide early guidance on appropriate therapy. In this study, we evaluated 128 patients with smear or real time polymerase chain reaction-confirmed Babesia microti infections over a period of 16 years. Patients with asplenia or immunocompromising conditions were more likely to have severe infection (P < 0...
July 10, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28683059/babesiosis-surveillance-wisconsin-2001-2015
#13
Elizabeth Stein, Lina I Elbadawi, James Kazmierczak, Jeffrey P Davis
Babesiosis is an emerging zoonotic disease caused primarily by Babesia microti, an intraerythocytic protozoan. Babesia microti, like the causal agents for Lyme disease and anaplasmosis, is endemic to the northeastern and upper midwestern United States where it is usually transmitted by the blacklegged tick, Ixodes scapularis. Although babesiosis is usually a mild to moderate illness, older or immunocompromised persons can develop a serious malaria-like illness that can be fatal without prompt treatment. The most common initial clinical signs and symptoms of babesiosis (fever, fatigue, chills, and diaphoresis) are nonspecific and present diagnostic challenges that can contribute to delays in diagnosis and effective treatment with atovaquone and azithromycin (1)...
July 7, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28655583/evaluation-of-the-inhibitory-effect-of-n-acetyl-l-cysteine-on-babesia-and-theileria-parasites
#14
Mohamed Abdo Rizk, Shimaa Abd El-Salam El-Sayed, Mahmoud AbouLaila, Naoaki Yokoyama, Ikuo Igarashi
N-acetyl-L-cysteine is known to have antibacterial, antiviral, antimalarial, and antioxidant activities. Therefore, the in vitro inhibitory effect of this hit was evaluated in the present study on the growth of Babesia and Theileria parasites. The in vitro growth of Babesia bovis, Babesia bigemina, Babesia divergens, Theileria equi, and Babesia caballi that were tested was significantly inhibited (P < 0.05) by micromolar concentrations of N-acetyl-L-cysteine. The inhibitory effect of N-acetyl-L-cysteine was synergistically potentiated when used in combination with diminazene aceturate on B...
August 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28648772/clinical-outbreak-of-babesiosis-caused-by-babesia-capreoli-in-captive-reindeer-rangifer-tarandus-tarandus-in-the-netherlands
#15
Jan H Bos, Fokko C Klip, Hein Sprong, Els M Broens, Marja J L Kik
From a herd of captive reindeer (Rangifer tarandus tarandus) consisting of two males and seven females with five calves, three calves were diagnosed on post mortem examination with a Babesia capreoli infection. The diagnosis was indicated by PCR and when the other reindeer were examined two adult females and a one-year-old male were Babesia-positive. Molecular characterization of the 18S rDNA of the parasite showed complete identity with known B. capreoli sequences. Ixodes ricinus has been demonstrated to be a competent vector for B...
August 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/28638376/first-molecular-detection-of-piroplasm-infection-in-pet-dogs-from-gansu-china
#16
Qingli Niu, Jifei Yang, Zhijie Liu, Shandian Gao, Yuping Pan, Guiquan Guan, Yuefeng Chu, Guangyuan Liu, Jianxun Luo, Hong Yin
Babesiosis, the hemolytic disease caused by Babesia, which is a tick-transmitted obligate intraerythrocytic protozoan parasite. This disease is responsible for significant mortality and morbidity rates and enormous economic losses to the livestock industry in tropical and subtropical regions worldwide. In this study, blood samples were collected from 141 pet dogs from Gansu, China, and analyzed for Babesia or Theileria spp. infection using specific PCR and sequencing based on 18S rRNA gene fragments. The results indicated that 18S rRNA gene sequences from 11 samples were similar to the 18S rRNA gene sequences in Babesia canis vogeli (2) and Theileria sinensis (9)...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28636757/babesiosis-an-unusual-cause-of-sepsis-after-kidney-transplantation-and-review-of-the-literature
#17
Imtiaz Ather, Negiin Pourafshar, Denise Schain, Asmita Gupte, Michael J Casey
We report a unique case of babesiosis presenting as sepsis after kidney transplantation. A 70-year-old female kidney transplant recipient presented with fever, hemolytic anemia, and acute kidney injury, and met three of four systemic inflammatory response syndrome criteria. Serology was positive for Babesia microti, confirmed by polymerase chain reaction. The patient was treated with atovaquone and azithromycin and made a full recovery. Reports of babesiosis after solid organ transplantation are rare, with only four prior cases reported in the literature...
June 21, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28634526/concurrent-babesiosis-and-serological-evidence-of-lyme-disease-in-a-young-patient
#18
Mark Adler, Thein Swe, Akari Thein Naing
Human babesiosis co-infected with Lyme disease in a young patient is an important condition. Here, we describe a case of a 39-year-old male patient with concurrent babesiosis and Lyme disease. Co-infections of tick borne diseases are often difficult to diagnose and underreported, and resulting in significant morbidity and mortality to patients. While co-infections have been infrequently described, it is of paramount importance that clinicians should be able to diagnose early and treat them effectively according to the patient geographical area and history of tick bite...
January 2017: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/28632488/vector-borne-pathogens-in-stray-dogs-in-northeastern-turkey
#19
Esin Guven, Hamza Avcioglu, Seyda Cengiz, Armagan Hayirli
This experiment was carried out to attain prevalence and molecular characterization of pathogens causing canine vector-borne diseases (CVBDs) including babesiosis, hepatozoonosis, leishmaniasis, filariosis (Dirofilaria immitis, Dirofilaria repens, and Acanthocheilonema reconditum), ehrlichiosis (Ehrlichia canis), and anaplasmosis (Anaplasma platys) in stray dogs. The study material consisted of 133 asymptomatic female (n = 96) and male (n = 37) stray dogs (≤1 year old, n = 16 and 1-6 years old, n = 117) housed in the Animal Care and Rehabilitation Center, Erzurum, Northeastern Turkey...
August 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28615859/molecular-identification-of-babesia-spp-in-naturally-infected-dogs-of-kerala-south-india
#20
Sneha Augustine, Lucy Sabu, Bindu Lakshmanan
Canine babesiosis is a tick borne haemoprotozoan disease caused by large and small intraerythrocytic apicomplexan piroplasms of the genus Babesia spp. The clinical manifestations of the disease vary from inapparent subclinical form to hyperacute shock related haemolytic crisis. Microscopic examination of blood smears from suspected dogs revealed Babesia canis and B. gibsoni in 3.45 and 25.86 % of samples respectively. A seminested PCR based on previously published species specific primers targeting the 18S rRNA gene was utilized to identify the Babesia species infecting dogs of Kerala at the sub species level...
June 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
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