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Sarah Elhamiani Khatat, Deborah Culang, Carolyn Gara-Boivin
Two dogs from Quebec were diagnosed with granulocytic anaplasmosis. They both displayed fever, lethargy, and anorexia. Other clinical signs included vomiting, uveitis, polyarthritis, hepatomegaly, and splenomegaly. Thrombocytopenia, anemia, and lymphopenia were identified in both cases. Cytoplasmic inclusions were observed within neutrophils, and Anaplasma phagocytophilum infection was confirmed by polymerase chain reaction in both dogs.
June 2018: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
Bruna Torres Silvestre, Júlia Angélica Gonçalves da Silveira, Elias Jorge Facury-Filho, Antônio Último de Carvalho, Alice Freitas Versiani, Letícia Gracielle Tôrres de Miranda Estevam, Márcio Sobreira Silva Araújo, Olindo Assis Martins-Filho, Deborah Aparecida Negrão-Corrêa, Múcio Flávio Barbosa Ribeiro
Vaccination against Anaplasma marginale has been considered an important control strategy for bovine anaplasmosis. Recently, mice immunized with rMSP1 a linked to carbon nanotubes (MWNT) showed significant immune responses, generating a new possibility for use of an inactivated vaccine. The objective of this study was to investigate the cellular and humoral responses in calves immunized with MWNT+rMSP1a , associated with inactivated vaccine of A. marginale produced in vitro, and evaluate the toxic effects of the MWNT on renal and hepatic function...
May 24, 2018: Revista Brasileira de Parasitologia Veterinária, Brazilian Journal of Veterinary Parasitology
Atle Mysterud, Vetle Malmer Stigum, Ingrid Vikingsdal Seland, Anders Herland, W Ryan Easterday, Solveig Jore, Olav Østerås, Hildegunn Viljugrein
BACKGROUND: Emergence of tick-borne diseases is impacting humans and livestock across the Northern Hemisphere. There are, however, large regional variations in number of cases of tick-borne diseases. Some areas have surprisingly few cases of disease compared to other regions. The aim here is to provide a first step towards a better understanding of such contrasting regional patterns of disease emergences at the northern distribution range of Ixodes ricinus in Europe. METHODS: We compare disease incidence, vector abundance and pathogen prevalence in eastern and western Norway differing in the number of tick-borne disease cases...
May 22, 2018: Parasites & Vectors
I I Shabana, N M Alhadlag, H Zaraket
BACKGROUND: The diagnosis of anaplasmosis is rather conflicting with other haemoprotozoans. Hence, the study aimed to compare and evaluate the efficiency of competitive ELISA (cELISA), indirect fluorescence antibody (IFA), and Polymerase chain reaction (PCR) for precise diagnosis of Anaplasma spp. and to assess their concordance with microscopic examination (ME). RESULTS: A total of 312 blood samples (189 sheep and 123 goats) were examined for Anaplasma infection during a 1 year period...
May 22, 2018: BMC Veterinary Research
Mourad Ben Said, Alaa Ben Asker, Hanène Belkahia, Raoua Ghribi, Rachid Selmi, Lilia Messadi
Anaplasma marginale, which is responsible for bovine anaplasmosis in tropical and subtropical regions, is a tick-borne obligatory intraerythrocytic bacterium of cattle and wild ruminants. In Tunisia, information about the genetic diversity and the phylogeny of A. marginale strains are limited to the msp4 gene analysis. The purpose of this study is to investigate A. marginale isolates infecting 16 cattle located in different bioclimatic areas of northern Tunisia with single gene analysis and multilocus sequence typing methods on the basis of seven partial genes (dnaA, ftsZ, groEL, lipA, secY, recA and sucB)...
May 12, 2018: Ticks and Tick-borne Diseases
Renata Welc-Falęciak, Justyna D Kowalska, Małgorzata Bednarska, Magdalena Szatan, Agnieszka Pawełczyk
BACKGROUND: The studies on the occurrence and diversity of tick-borne infections in HIV-infected individuals have been few, and the subject has been relatively neglected when compared with other common infections associated with HIV. In HIV-positive patients in whom a serological diagnostics is complicated due to reduced positive predictive value, a method where the microorganism is detected directly is of great value. Therefore, we performed a molecular study to ascertain the prevalence and incidence of tick-borne infections in HIV-infected persons in Poland, an endemic area for Ixodes ricinus ticks...
May 18, 2018: BMC Infectious Diseases
Kelsey D Wilson, Dirk M Elston
The Ixodes tick is an important arthropod vector in the transmission of human disease. Although Lyme disease is the most prevalent zoonosis transmitted by Ixodes ticks, other less common diseases may be encountered, including human granulocytic anaplasmosis, babesiosis, Powassan virus infection, tick-borne encephalitis, Borrelia miyamotoi disease, and tick paralysis. In part 2 of this review, disease presentation, diagnosis, and treatment of these less commonly encountered tick-borne diseases are discussed.
April 2018: Cutis; Cutaneous Medicine for the Practitioner
Shahid Hussain Farooqi, Muhammad Ijaz, Muhammad Imran Rashid, H Nabi, S Islam, Amjad Islam Aqib, Kashif Hussain, Amjad Khan, Syeda Nayab Batool Rizvi, Shakeel Mahmood, Khalid Mehmood, Hui Zhang
Bovine anaplasmosis is endemic in Pakistan where it reduces livestock productivity and leads to high mortality, especially in young animals. This study was aimed to identify the potential risk factors responsible for the occurrence and spread of anaplasmosis in cattle and buffaloes for the first time in Pakistan. A total of 900 (cattle = 479, buffalo = 421) blood samples were collected irrespective of age and sex from three distinct zones of Khyber Pakhtunkhhwa (KP) province of Pakistan. Polymerase chain reaction (PCR) technique was used for the molecular detection of anaplasmosis...
May 8, 2018: Tropical Animal Health and Production
Seyedeh Missagh Jalali, Masood Ghorbanpour, Mohammad Razi Jalali, Aria Rasooli, Pegah Safaie, Farideh Norvej, Imaneh Delavari
The main objectives of this study were to determine the occurrence and potential causative factors of Immune-mediated hemolytic anemia (IMHA) in native cattle and water buffaloes from southwest of Iran. Fifty-three anemic animals (37 cattle and 16 buffaloes) were studied. A full clinical history and physical examinations were undertaken for all animals. Four clinically healthy cattle and four healthy buffaloes were also used as control animals. Blood samples were subjected to a complete blood count, Coombs' test, erythrocyte osmotic fragility test and serum biochemical analysis...
2018: Veterinary Research Forum
Kelsey D Wilson, Dirk M Elston
The Ixodes tick is an important arthropod vector in the transmission of human disease. This 3-part review highlights the biology of the Ixodes tick and manifestations of related diseases. Part 1 addresses the Ixodes tick biology and life cycle; local reactions; and Lyme disease, the most prevalent of associated diseases. Part 2 will address human granulocytic anaplasmosis, babesiosis, Powassan virus infection, Borrelia miyamotoi disease, tick-borne encephalitis, and tick paralysis. Part 3 will address coinfection with multiple pathogens as well as methods of tick-bite prevention and tick removal...
March 2018: Cutis; Cutaneous Medicine for the Practitioner
Yuichi Fukui, Seigo Ohkawa, Hisashi Inokuma
Anaplasma phagocytophilum DNA was detected from a dog with canine granulocytic anaplasmosis (CGA) in Japan. Phylogenetic analysis of the DNA using 16s rRNA, gltA, and groEL sequences revealed that the strain was nearly identical to A. phagocytophilum detected from Apodemus agrarius (black-striped field mouse) in China and Korea. This report is the first phylogenetic study on A. phagocytophilum from a CGA case in Japan.
April 27, 2018: Japanese Journal of Infectious Diseases
Diana G Scorpio, Kyoung-Seong Choi, J Stephen Dumler
Human granulocytic anaplasmosis, caused by the tick-transmitted Anaplasma phagocytophilum , is not controlled by innate immunity, and induces a proinflammatory disease state with innate immune cell activation. In A. phagocytophilum murine infection models, hepatic injury occurs with production of IFNγ thought to be derived from NK, NKT cells, and CD8 T lymphocytes. Specific A. phagocytophilum ligands that drive inflammation and disease are not known, but suggest a clinical and pathophysiologic basis strikingly like macrophage activation syndrome (MAS) and hemophagocytic syndrome (HPS)...
2018: Frontiers in Immunology
Min-Goo Seo, In-Ohk Ouh, Oh-Deog Kwon, Dongmi Kwak
Anaplasma phagocytophilum is the causative agent of human granulocytic anaplasmosis and tick-borne fever in domestic ruminants. Differential diagnosis of zoonotic and pathogenic tick-borne diseases like granulocytic anaplasmosis is important for the efficient implementation of control programs. Thus, the differentiation of pathogenic A. phagocytophilum from non-pathogenic A. phagocytophilum-like (APL) Anaplasma spp. is essential. Recent molecular analyses of APL revealed its distinct phylogenetic position from A...
April 10, 2018: Molecular Phylogenetics and Evolution
Emil Hovius, Arnout de Bruin, Leo Schouls, Joppe Hovius, Niels Dekker, Hein Sprong
BACKGROUND: Various tick-borne infections often occur without specific clinical signs and are therefore notoriously hard to diagnose separately in veterinary practice. Longitudinal studies over multiple tick seasons performing clinical, serological and molecular investigations in parallel, may elucidate the relationship between infection and disease. In this regard, six related Rhodesian Ridgeback dogs living as a pack became subject of lifetime studies due to ongoing tick infestations and recurring clinical problems...
April 12, 2018: Parasites & Vectors
Sehrish Saleem, Muhammad Ijaz, Shahid Hussain Farooqi, Awais Ghaffar, Ahmad Ali, Kashif Iqbal, Khalid Mehmood, Hui Zhang
Equine granulocytic anaplasmosis (EGA) is an important tick borne disease of equines that is caused by Anaplasma phagocytophilum (A. phagocytophilum). The etiological agent has veterinary as well as public health importance because of its zoonotic nature. A. phagocytophilum causes an acute illness in equines with loss of appetite, lethargy, hemorrhages and lameness. Clinically, EGA is diagnosed upon examination of morulae within neutrophils especially granulocytes in the blood. The best diagnostic tool for the detection of EGA is Polymerase chain reaction (PCR)...
June 2018: Microbial Pathogenesis
Ahmad Jafar Bekloo, Maryam Roya Ramzgouyan, Sadegh Shirian, Faezeh Faghihi, Hassan Bakhshi, Fatemeh Naseri, Mehdi Sedaghat, Zakkyeh Telmadarraiy
INTRODUCTION: Anaplasma/Ehrlichia species are tick-transmitted pathogens that cause infections in humans and numerous domestic and wild animal species. There is no information available on the molecular characteristics and phylogenetic position of Anaplasma/Ehrlichia spp. isolated from tick species from different geographic locations in Iran. The aim of this study was to determine the prevalence, molecular characteristics, and phylogenetic relationship of both Anaplasma spp. and Ehrlichia spp...
May 2018: Vector Borne and Zoonotic Diseases
Stefan Edginton, T Hugh Guan, Gerald Evans, Siddhartha Srivastava
No abstract text is available yet for this article.
March 26, 2018: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
G V Gioia, R L Vinueza, M Marsot, E Devillers, M Cruz, E Petit, H J Boulouis, S Moutailler, F Monroy, M A Coello, M Gondard, L Bournez, N Haddad, G Zanella
A cross-sectional study was conducted to determine the species of Anaplasma spp. and estimate its prevalence in cattle of the three main cattle-producing Galapagos Islands (Santa Cruz, San Cristóbal and Isabela) using indirect PCR assays, genetic sequencing and ELISA. Ticks were also collected from cattle and scanned for 47 tick-borne pathogens in a 48 × 48 real-time PCR chip. A mixed effects logistic regression was performed to identify potential risk factors explaining Anaplasma infection in cattle. A...
March 22, 2018: Transboundary and Emerging Diseases
Ferda Sevinc, Mo Zhou, Shinuo Cao, Onur Ceylan, Mehmet Fatih Aydin, Mutlu Sevinc, Xuenan Xuan
Babesiosis, theileriosis, and anaplasmosis are the most common tick-borne diseases in sheep. The majority of anaplasmosis and theileriosis are subclinical; however, babesiosis causes severe infections in small ruminants. Although there are many reports of co-infections with the agents of these diseases, their clinical severity compared with either of the infections alone is unknown. Within the host, interactions between co-infecting species may cause variations in clinical presentation and response to therapy...
March 15, 2018: Veterinary Parasitology
Silvia Ravagnan, Laura Tomassone, Fabrizio Montarsi, Aleksandra Iwona Krawczyk, Eleonora Mastrorilli, Hein Sprong, Adelaide Milani, Luca Rossi, Gioia Capelli
BACKGROUND: Borrelia miyamotoi is a spirochete transmitted by several ixodid tick species. It causes a relapsing fever in humans and is currently considered as an emerging pathogen. In Europe, B. miyamotoi seems to occur at low prevalence in Ixodes ricinus ticks but has a wide distribution. Here we report the first detection of B. miyamotoi in Ixodes ricinus ticks collected in two independent studies conducted in 2016 in the north-eastern and north-western Alps, Italy. RESULTS: Three out of 405 nymphs (0...
March 20, 2018: Parasites & Vectors
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