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https://www.readbyqxmd.com/read/29453420/a-multiplex-serologic-platform-for-diagnosis-of-tick-borne-diseases
#1
Rafal Tokarz, Nischay Mishra, Teresa Tagliafierro, Stephen Sameroff, Adrian Caciula, Lokendrasingh Chauhan, Jigar Patel, Eric Sullivan, Azad Gucwa, Brian Fallon, Marc Golightly, Claudia Molins, Martin Schriefer, Adriana Marques, Thomas Briese, W Ian Lipkin
Tick-borne diseases are the most common vector-borne diseases in the United States, with serology being the primary method of diagnosis. We developed the first multiplex, array-based assay for serodiagnosis of tick-borne diseases called the TBD-Serochip. The TBD-Serochip was designed to discriminate antibody responses to 8 major tick-borne pathogens present in the United States, including Anaplasma phagocytophilum, Babesia microti, Borrelia burgdorferi, Borrelia miyamotoi, Ehrlichia chaffeensis, Rickettsia rickettsii, Heartland virus and Powassan virus...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29422446/molecular-detection-and-phylogenetic-analysis-of-anaplasma-marginale-and-anaplasma-centrale-amongst-transhumant-cattle-in-north-eastern-uganda
#2
Charles Byaruhanga, Nicola E Collins, Darryn L Knobel, Zamantungwa T H Khumalo, Mamohale E Chaisi, Marinda C Oosthuizen
There is little molecular data from Anaplasma marginale and Anaplasma centrale isolates from cattle in Uganda. Between November 2013 and January 2014, blood was collected from 240 cattle in 20 randomly-selected herds in two districts of the Karamoja Region in north-eastern Uganda. A duplex quantitative real-time polymerase chain reaction (qPCR) assay was used to detect and determine the prevalence of A. marginale (targeting the msp1β gene) and A. centrale (targeting the groEL gene). The qPCR assay revealed that most cattle (82...
February 1, 2018: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29415034/molecular-characterization-of-the-recombinant-protein-rmlti-bmcg-ltb-protective-immunity-against-rhipicephalus-boophilus-microplus
#3
Bárbara Guimarães Csordas, Rodrigo Casquero Cunha, Marcos Valério Garcia, Sérgio Silva da Silva, Fábio Leivas Leite, Renato Andreotti
The bovine tick Rhipicephalus (Boophilus) microplus is found in several tropical and subtropical regions of the world. This parasite transmits pathogens that cause disease, such as babesiosis (Babesia bovis and B. bigemina) and anaplasmosis (Anaplasma marginale). Tick infestations cause enormous livestock losses, and controlling tick infestations and the transmission of tick-borne diseases remains a challenge for the livestock industry. Because the currently available commercial vaccines offer only partial protection against R...
2018: PloS One
https://www.readbyqxmd.com/read/29398603/pathogen-transmission-in-relation-to-duration-of-attachment-by-ixodes-scapularis-ticks
#4
REVIEW
Lars Eisen
The blacklegged tick, Ixodes scapularis, is the primary vector to humans in the eastern United States of the deer tick virus lineage of Powassan virus (Powassan virus disease); the protozoan parasite Babesia microti (babesiosis); and multiple bacterial disease agents including Anaplasma phagocytophilum (anaplasmosis), Borrelia burgdorferi and Borrelia mayonii (Lyme disease), Borrelia miyamotoi (relapsing fever-like illness, named Borrelia miyamotoi disease), and Ehrlichia muris eauclairensis (a minor causative agent of ehrlichiosis)...
January 31, 2018: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29398602/anaplasma-spp-in-north-africa-a-review-on-molecular-epidemiology-associated-risk-factors-and-genetic-characteristics
#5
REVIEW
Mourad Ben Said, Hanène Belkahia, Lilia Messadi
The genus Anaplasma belonging to the Anaplasmataceae family (order Rickettsiales) comprises obligate intracellular Gram-negative bacteria of veterinary and public health importance. Six species and five types of strains genetically related are currently assigned to the genus Anaplasma including Anaplasma marginale, A. centrale, A. bovis, A. phagocytophilum, A. ovis and A. platys as classified species, and "A. capra", A. odocolei sp. nov., A. phagocytophilum-like 1 (Anaplasma sp.-Japan), A. phagocytophilum-like 2 (Anaplasma sp...
February 1, 2018: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29351812/a-hybrid-protein-containing-msp1a-repeats-and-omp7-omp8-and-omp9-epitopes-protect-immunized-balb-c-mice-against-anaplasmosis
#6
Alex Sander R Cangussu, Luis André M Mariúba, Pritesh Lalwani, Keila Dayane E S Pereira, Spartaco Astolphi-Filho, Patricia P Orlandi, Sabrina Epiphanio, Kelvison F Viana, Mucio Flavio B Ribeiro, Hidelberto M Silva, Claudio R F Marinho, Paulo A Nogueira
Anaplasma marginale (A. marginale) has a remarkable impact on livestock production, and an effective vaccine is not currently available due to the inexistence of a small animal model. Recently, BALB/c mice were successfully infected with A. marginale, resulting in an acute and persistent anaplasmosis infection. Here, we designed a hybrid protein containing repeats of polypeptide 1a from major surface protein-1 complex (MSP1a) repeats and common epitopes of outer membrane proteins (OMPs) OMP7, OMP8 and OMP9 expressed in Escherichia coli...
January 19, 2018: Veterinary Research
https://www.readbyqxmd.com/read/29336985/the-blacklegged-tick-ixodes-scapularis-an-increasing-public-health-concern
#7
REVIEW
Rebecca J Eisen, Lars Eisen
In the United States, the blacklegged tick, Ixodes scapularis, is a vector of seven human pathogens, including those causing Lyme disease, anaplasmosis, babesiosis, Borrelia miyamotoi disease, Powassan virus disease, and ehrlichiosis associated with Ehrlichia muris eauclarensis. In addition to an accelerated rate of discovery of I. scapularis-borne pathogens over the past two decades, the geographic range of the tick, and incidence and range of I. scapularis-borne disease cases, have increased. Despite knowledge of when and where humans are most at risk of exposure to infected ticks, control of I...
January 11, 2018: Trends in Parasitology
https://www.readbyqxmd.com/read/29329629/estimates-of-repeatability-and-correlations-of-hemoparasites-infection-levels-for-cattle-reared-in-endemic-areas-for-rhipicephalus-microplus
#8
Rodrigo Giglioti, Henrique Nunes de Oliveira, Talita Barban Bilhassi, Amanda Izeli Portilho, Cintia Hiromi Okino, Cintia Righetti Marcondes, Marcia Cristina de Sena Oliveira
Rhipicephalus microplus is a vector of cattle tick fever, a disease caused by the protozoans Babesia bovisand B. bigemina, and also anaplasmosis, produced by the Rickettsiales Anaplasma marginale. These tick-borne pathogens cause considerable losses to Brazilian livestock breeders and represent an obstacle to the expanded use of taurine breeds due to their higher sensitivity to ticks and hemoparasites compared to zebu breeds. Differences in the susceptibility to hemoparasites were also verified within breeds, suggesting that may be possible to select a most resistant phenotype...
January 30, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29310697/epidemiology-genetic-variants-and-clinical-course-of-natural-infections-with-anaplasma-phagocytophilum-in-a-dairy-cattle-herd
#9
Cornelia Silaghi, Marion Nieder, Carola Sauter-Louis, Gabriela Knubben-Schweizer, Kurt Pfister, Martin Pfeffer
BACKGROUND: Anaplasma phagocytophilum is an obligate intracellular, tick-transmitted bacterium that causes granulocytic anaplasmosis in humans and several mammalian species including domestic ruminants where it is called tick-borne fever (TBF). Different genetic variants exist but their impact with regard to putative differences in host associations and pathogenicity are not yet completely understood. METHODS: Natural infections with A. phagocytophilum in a dairy cattle herd in Germany were investigated over one pasture season by using serology, haematology, blood chemistry and polymerase chain reaction (PCR)...
January 8, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29306724/first-molecular-evidence-of-equine-granulocytic-anaplasmosis-in-pakistan
#10
Sehrish Saleem, Muhammad Ijaz, Shahid Hussain Farooqi, Muhammad Imran Rashid, Amjad Khan, Awais Masud, Amjad Islam Aqib, Kashif Hussain, Khalid Mehmood, Hui Zhang
Anaplasma phagocytophilum (A. phagocytophilum) is an obligate intracellular bacterium that causes equine granulocytic anaplasmosis (EGA) disease in equines. This pathogen has zoonotic potential, which makes it very important to be detected and controlled as early as possible. This study was aimed to assess the molecular prevalence, associated risk factors of EGA along with its effects on various hematological parameters. This study revealed an overall 10.67% prevalence in equine. Horses showed highest prevalence followed by mules and donkeys presenting 11...
January 5, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29258802/a-molecular-algorithm-to-detect-and-differentiate-human-pathogens-infecting-ixodes-scapularis-and-ixodes-pacificus-acari-ixodidae
#11
Christine B Graham, Sarah E Maes, Andrias Hojgaard, Amy C Fleshman, Sarah W Sheldon, Rebecca J Eisen
The incidence and geographic range of tick-borne illness associated with Ixodes scapularis and Ixodes pacificus have dramatically increased in recent decades. Anaplasmosis, babesiosis, and Borrelia spirochete infections, including Lyme borreliosis, account for tens of thousands of reported cases of tick-borne disease every year. Assays that reliably detect pathogens in ticks allow investigators and public health agencies to estimate the geographic distribution of human pathogens, assess geographic variation in their prevalence, and evaluate the effectiveness of prevention strategies...
December 10, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29249727/expression-purification-and-biological-characterization-of-anaplasma-phagocytophilum-enolase
#12
Xiaoge Gao, Chen Zheng, Xiangye Liu
The obligate intracellular bacteria Anaplasma phagocytophilum is the etiological agent of human granulocytic anaplasmosis (HGA), an acute febrile tick-borne disease. A. phagocytophilum has a complex lifecycle within both vertebrate reservoirs and tick vectors, and employs a range of different molecules to infect and multiply within the host cells. Enolase is an essential glycolytic enzyme in intracellular glucose metabolism, but is also a multifunctional protein expressed on the pathogen surface, that binds to and promotes plasminogen conversion to plasmin...
December 17, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/29246225/pcr-diagnosis-of-anaplasma-marginale-in-cattle-populations-of-ecuador-and-its-molecular-identification-through-sequencing-of-ribosomal-16s-fragments
#13
Leandro Tana-Hernández, Katherine Navarrete-Arroyo, Jorge Ron-Román, Armando Reyna-Bello, María Augusta Chávez-Larrea
BACKGROUND: Bovine anaplasmosis is an endemic disease in tropical and subtropical areas. It is caused by a bacterium named Anaplasma marginale, and represents an economic problem for cattle farmers due to the losses it generates, such as: mortalities, reduced production, quarantine measures, treatments and control of vectors. The method most often used to diagnose this haemotrophic bacterium is direct examination on blood smear, which sensitivity and specificity are limited compared to other methods such as PCR...
December 15, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29227140/range-expansion-of-the-economically-important-asiatic-blue-tick-i-rhipicephalus-microplus-i-in-south-africa
#14
Nkululeko Nyangiwe, Ivan G Horak, Luther Van der Mescht, Sonja Matthee
The Asiatic blue tick, Rhipicephalus microplus, a known vector of bovine babesiosis and bovine anaplasmosis, is of great concern in the cattle industry. For this reason, detailed knowledge of the distribution of R. microplus is vital. Currently, R. microplus is believed to be associated mainly with the northern and eastern Savanna and Grassland vegetation in South Africa. The objective of the study was to record the distribution of R. microplus, and the related endemic Rhipicephalus decoloratus, in the central-western region of South Africa that comprises Albany Thicket, Fynbos and Savanna vegetation...
December 8, 2017: Journal of the South African Veterinary Association
https://www.readbyqxmd.com/read/29202672/sensitivity-and-specificity-levels-of-two-rapid-assays-for-antibodies-to-anaplasma-spp-in-dogs
#15
Jiayou Liu, Matthew Eberts, Hannah Bewsey, Thomas P O'Connor, Ramaswamy Chandrashekar, Edward B Breitschwerdt
Canine anaplasmosis is a tick-borne disease of dogs that results following infection with Anaplasma phagocytophilum or Anaplasma platys. The SNAP 4Dx Plus test (IDEXX Laboratories) and the VetScan Canine Anaplasma Rapid test (Abaxis) are commercial in-house rapid tests for the detection of antibody to these 2 antigenically related Anaplasma species. We evaluated 2 tests using serum and whole blood samples obtained from reference laboratories and veterinary hospitals. Samples were obtained from regions of the country known to be habitats of the primary tick vectors...
December 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/29202206/ehrlichia-and-anaplasma-infections-serological-evidence-and-tick-surveillance-in-peninsular-malaysia
#16
Fui Xian Koh, Kai Ling Kho, Masoumeh Ghane Kisomi, Li Ping Wong, Awang Bulgiba, Poai Ean Tan, Yvonne Ai Lian Lim, Quaza Nizamuddin Hassan Nizam, Chandrawathani Panchadcharam, Sun Tee Tay
Little information is available on human anaplasmosis and ehrlichiosis in Southeast Asia despite increasing reports of the detection of Anaplasma spp. and Ehrlichia spp. in the ticks. We report herein the serological findings against the tick-borne pathogens in a group of animal farm workers (n = 87) and indigenous people (n = 102) in Peninsular Malaysia. IgG antibodies against Ehrlichia chaffeensis were detected from 29.9% and 34.3% of farm workers and indigenous people, respectively, using commercial indirect immunofluorescence assays...
November 30, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29176601/emergence-of-tick-borne-diseases-at-northern-latitudes-in-europe-a-comparative-approach
#17
Atle Mysterud, Solveig Jore, Olav Østerås, Hildegunn Viljugrein
The factors that drive the emergence of vector-borne diseases are difficult to identify due to the complexity of the pathogen-vector-host triad. We used a novel comparative approach to analyse four long-term datasets (1995-2015) on the incidence of tick-borne diseases in humans and livestock (Lyme disease, anaplasmosis and babesiosis) over a geographic area that covered the whole of Norway. This approach allowed us to separate general (shared vector) and specific (pathogen reservoir host) limiting factors of tick-borne diseases, as well as the role of exposure (shared and non-shared pathogens in different hosts)...
November 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29173127/integrated-control-of-nymphal-ixodes-scapularis-effectiveness-of-white-tailed-deer-reduction-the-entomopathogenic-fungus-metarhizium-anisopliae-and-fipronil-based-rodent-bait-boxes
#18
Scott C Williams, Kirby C Stafford, Goudarz Molaei, Megan A Linske
Pathogens transmitted by ticks are the leading cause of arthropod-associated human diseases in the United States and managing the risk of exposure to potentially infected ticks is of vital public health importance. A 3-year integrated tick management program to control blacklegged ticks, Ixodes scapularis, the primary vector for the pathogenic agents of Lyme disease, human anaplasmosis, and babesiosis, was implemented in the town of Redding in southwestern Connecticut beginning in 2013. Combinations of white-tailed deer, Odocoileus virginianus, reduction, area application of the entomopathogenic fungus Metarhizium anisopliae, and fipronil-based rodent bait boxes were evaluated for their ability to reduce nymphal I...
November 27, 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/29171663/granulocytic-anaplasmosis-in-63-dogs-clinical-signs-laboratory-results-therapy-and-course-of-disease
#19
A Chirek, C Silaghi, K Pfister, B Kohn
OBJECTIVES: To describe the clinical signs, laboratory results, therapy and course of disease in dogs with canine granulocytic anaplasmosis in which co-infections had been excluded. METHODS: Medical records of dogs naturally infected with Anaplasma phagocytophilum were retrospectively evaluated with regard to clinical signs and laboratory abnormalities at the time of presentation, therapy and course of disease. RESULTS: Nine hundred and seventy-four dogs with clinical signs suspicious for canine granulocytic anaplasmosis were tested for A...
November 24, 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/29141715/clinical-isolation-of-anaplasma-phagocytophilum-in-south-korea
#20
Seung Hun Lee, Se Yoon Park, Mi Jin Jang, Ki Ju Choi, Hae Kyung Lee, Young-Uk Cho, Yeong Seon Lee, Sung-Han Kim, Seon Do Hwang
We report the first isolation of Anaplasma phagocytophilum in South Korea. A 61-year-old woman presented with a 6-day history of fever, headache, and myalgia. Initial investigation showed neutropenia and thrombocytopenia. We diagnosed human granulocytic anaplasmosis by microscopic examination and serologic testing. The patient recovered fully without antibiotic therapy. The isolate was obtained from the patient's blood by cell culture and mouse inoculation. Its identity was confirmed by an immunofluorescence assay, sequencing of the 16S rRNA gene, msp2 (p44), and ankA genes, and staining and electron microscopy of morulae of A...
October 30, 2017: American Journal of Tropical Medicine and Hygiene
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