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https://www.readbyqxmd.com/read/29040182/variable-clinical-presentations-of-babesiosis-a-case-series
#1
Pamela Paparone, Philip W Paparone
Human babesiosis continues to spread in multiple regions of the United States. It is transmitted by Ixodes species ticks, as are Lyme disease and anaplasmosis. Its variable clinical presentations, together with serologic detection limitations, require that a high index of clinical suspicion be present for prompt diagnosis. This article discusses case presentations showing the wide range of symptoms and presentations that are possible with babesiosis.
November 16, 2017: Nurse Practitioner
https://www.readbyqxmd.com/read/29038575/human-rickettsial-pathogen-modulates-arthropod-organic-anion-transporting-polypeptide-and-tryptophan-pathway-for-its-survival-in-ticks
#2
Vikas Taank, Shovan Dutta, Amrita Dasgupta, Tanner K Steeves, Durland Fish, John F Anderson, Hameeda Sultana, Girish Neelakanta
The black-legged tick Ixodes scapularis transmits the human anaplasmosis agent, Anaplasma phagocytophilum. In this study, we show that A. phagocytophilum specifically up-regulates I. scapularis organic anion transporting polypeptide, isoatp4056 and kynurenine amino transferase (kat), a gene involved in the production of tryptophan metabolite xanthurenic acid (XA), for its survival in ticks. RNAi analysis revealed that knockdown of isoatp4056 expression had no effect on A. phagocytophilum acquisition from the murine host but affected the bacterial survival in tick cells...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29037863/outer-membrane-protein-ompb-methylation-may-mediate-bacterial-virulence
#3
REVIEW
David C H Yang, Amila H Abeykoon, Bok-Eum Choi, Wei-Mei Ching, P Boon Chock
Methylation of outer membrane proteins (OMPs) has been implicated in bacterial virulence. Lysine methylation in rickettsial OmpB is correlated with rickettsial virulence, and N- and O-methylations are also observed in virulence-relevant OMPs from several pathogenic bacteria that cause typhus, leptospirosis, tuberculosis, and anaplasmosis. We summarize recent findings on the structure of methylated OmpB, biochemical characterization, and crystal structures of OmpB methyltransferases. Native rickettsial OmpB purified from highly virulent strains contains multiple clusters of trimethyllysine, in contrast with mostly monomethyllysine, and no trimethyllysine is found in an avirulent strain...
October 13, 2017: Trends in Biochemical Sciences
https://www.readbyqxmd.com/read/29034616/molecular-survey-and-genetic-characterization-of-anaplasma-centrale-a-marginale-and-a-bovis-in-cattle-from-algeria
#4
M R Rjeibi, O Ayadi, M Rekik, M Gharbi
Bovine anaplasmosis could be caused by several Anaplasma species. The causative agents are transmitted by ticks and haematophagous arthropods with a high impact on both human and animal health. This study was conducted to estimate the infection rate and to characterize Anaplasma spp. in cattle from Algeria. A molecular survey was performed in Setif district (Northeast Algeria) where a total number of 180 cattle blood samples were collected and tested for the presence of Anaplasma spp. by PCR. Positive samples were genetically characterized based on the 16S rRNA and msp4 genes...
October 16, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/28939494/prevalence-risk-factors-and-vectors-identification-of-bovine-anaplasmosis-and-babesiosis-in-and-around-jimma-town-southwestern-ethiopia
#5
Nejash Abdela, Nuraddis Ibrahim, Feyissa Begna
Among tick-borne diseases, bovine anaplasmosis and babesiosis are considered to be one of the most important in ruminants worldwide, causing significant economic losses in tropical and subtropical areas. This cross-sectional study was therefore undertaken from November 2016 to April 2017 with the objectives to assess the prevalence and potential risk factors associated with bovine anaplasmosis and babesiosis and also to identify the vectors involved in transmission of these diseases in and around Jimma town, south western Ethiopia...
September 19, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28929088/microbial-invasion-vs-tick-immune-regulation
#6
REVIEW
Daniel E Sonenshine, Kevin R Macaluso
Ticks transmit a greater variety of pathogenic agents that cause disease in humans and animals than any other haematophagous arthropod, including Lyme disease, Rocky Mountain spotted fever, human granulocytic anaplasmosis, babesiosis, tick-borne encephalitis, Crimean Congo haemorhagic fever, and many others (Gulia-Nuss et al., 2016). Although diverse explanations have been proposed to explain their remarkable vectorial capacity, among the most important are their blood feeding habit, their long term off-host survival, the diverse array of bioactive molecules that disrupt the host's natural hemostatic mechanisms, facilitate blood flow, pain inhibitors, and minimize inflammation to prevent immune rejection (Hajdušek et al...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28915997/outbreak-of-anaplasmosis-associated-with-novel-genetic-variants-of-anaplasma-marginale-in-a-dairy-cattle
#7
Munir Aktas, Sezayi Özübek
During early lactation, dairy cows may present a transient immunosuppressive state and develop anaplasmosis caused by Anaplasma marginale. In this study, clinical anaplasmosis in dairy cattle in the Thrace region of Turkey was investigated with respect to within-herd prevalence, vertical transmission, and genetic diversity. In March and September 2015, thirty lactating cows showed primary clinical signs of anaplasmosis, including fever, anaemia, decreased milk yield, anorexia, and laboured breathing. Symptoms disappeared in most cows after administration of long-acting oxytetracycline, but nine of them (30%) died...
October 2017: Comparative Immunology, Microbiology and Infectious Diseases
https://www.readbyqxmd.com/read/28888642/spatio-temporal-variations-and-genetic-diversity-of-anaplasma-spp-in-cattle-from-the-north-of-tunisia
#8
Hanène Belkahia, Mourad Ben Said, Narjesse El Mabrouk, Mariem Saidani, Chayma Cherni, Mariem Ben Hassen, Ali Bouattour, Lilia Messadi
In cattle, anaplasmosis is a tick-borne rickettsial disease caused by Anaplasma marginale, A. centrale, A. phagocytophilum, and A. bovis. To date, no information concerning the seasonal dynamics of single and/or mixed infections by different Anaplasma species in bovines are available in Tunisia. In this work, a total of 1035 blood bovine samples were collected in spring (n=367), summer (n=248), autumn (n=244) and winter (n=176) from five different governorates belonging to three bioclimatic zones from the North of Tunisia...
September 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28861402/ixodes-scapularis-tick-cells-control-anaplasma-phagocytophilum-infection-by-increasing-the-synthesis-of-phosphoenolpyruvate-from-tyrosine
#9
Alejandro Cabezas-Cruz, Pedro J Espinosa, Dasiel A Obregón, Pilar Alberdi, José de la Fuente
The obligate intracellular pathogen, Anaplasma phagocytophilum, is the causative agent of life-threatening diseases in humans and animals. A. phagocytophilum is an emerging tick-borne pathogen in the United States, Europe, Africa and Asia, with increasing numbers of infected people and animals every year. It is increasingly recognized that intracellular pathogens modify host cell metabolic pathways to increase infection and transmission in both vertebrate and invertebrate hosts. Recent reports have shown that amino acids are central to the host-pathogen metabolic interaction...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28859959/first-confirmed-report-of-outbreak-of-theileriosis-anaplasmosis-in-a-cattle-farm-in-henan-china
#10
Yanyan Cui, Xiaoxing Wang, Yan Zhang, Yaqun Yan, Haiju Dong, Fuchun Jian, Ke Shi, Longxian Zhang, Rongjun Wang, Changshen Ning
Tick-borne diseases (TBDs) impose a significant constraint to livestock production world widely. In this paper, we presented a case of TBD in a cattle farm in Henan, China. 35 blood samples (7 samples sent by veterinarian, 28 samples gathered by our colleagues) were collected from ill, surviving and asymptomatic cattle and microscopic observation and PCR assays were conducted to characterize the pathogens. Genus Ixodes feeding on these cattle were collected and identified. Theileria annulata-like and Anaplasma marginale-like pathogens were observed in the blood smears stained with Giemsa staining under microscope...
August 28, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28829732/case-report-polymerase-chain-reaction-testing-of-tick-bite-site-samples-for-the-diagnosis-of-human-granulocytic-anaplasmosis
#11
Choon-Mee Kim, Seok Won Kim, Dong-Min Kim, Na-Ra Yoon, Piyush Jha, Sook Jin Jang, Young-Joon Ahn, Donghoon Lim, Seung Hun Lee, Seon Do Hwang, Yeong Seon Lee
Human granulocytic anaplasmosis (HGA) is a tick-borne infectious disease caused by Anaplasma phagocytophilum, an obligate intracellular bacterium. Until now, the utility of tick-bite site samples for HGA diagnosis has not been reported. Using a patient's buffy coat and tick-bite site crust samples, we performed polymerase chain reaction (PCR) testing using Ehrlichia- or Anaplasma-specific primers. PCR with buffy coat and crust samples obtained before doxycycline administration was positive. Six days after doxycycline administration, PCR with the buffy coat sample was negative but PCR with a crust tissue sample from the tick-bite site remained positive...
August 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28797056/anaplasma-phagocytophilum-infection-modulates-expression-of-megakaryocyte-cell-cycle-genes-through-phosphatidylinositol-3-kinase-signaling
#12
Supreet Khanal, Hameeda Sultana, John D Catravas, Jason A Carlyon, Girish Neelakanta
Anaplasma phagocytophilum, the agent of human granulocytic anaplasmosis infects neutrophils and other cells from hematopoietic origin. Using human megakaryocytic cell line, MEG-01, we show that expression of cell cycle genes in these cells are altered upon A. phagocytophilum infection. Expression of several cell cycle genes in MEG-01 cells was significantly up regulated at early and then down regulated at later stages of A. phagocytophilum infection. Lactate dehydrogenase (LDH) assays revealed reduced cellular cytotoxicity in MEG-01 cells upon A...
2017: PloS One
https://www.readbyqxmd.com/read/28764743/one-particular-anaplasma-phagocytophilum-ecotype-infects-cattle-in-the-camargue-france
#13
Thibaud Dugat, Agnès Leblond, Nicolas Keck, Anne-Claire Lagrée, Isabelle Desjardins, Aurélien Joulié, Sophie Pradier, Benoit Durand, Henri-Jean Boulouis, Nadia Haddad
BACKGROUND: Anaplasma phagocytophilum is a zoonotic tick-borne pathogen responsible for granulocytic anaplasmosis, a mild to a severe febrile disease that affects man and several animal species, including cows and horses. In Europe, I. ricinus is the only proven vector for this pathogen, but studies suggest that other tick genera and species could be involved in its transmission. Our objective was to assess the presence and genetic diversity of A. phagocytophilum in domestic animals and different tick species from the Camargue region, located in the south of France...
August 2, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28754599/bioassays-to-evaluate-non-contact-spatial-repellency-contact-irritancy-and-acute-toxicity-of-permethrin-treated-clothing-against-nymphal-ixodes-scapularis-ticks
#14
Lars Eisen, Dominic Rose, Robert Prose, Nicole E Breuner, Marc C Dolan, Karen Thompson, Neeta Connally
Summer-weight clothing articles impregnated with permethrin are available as a personal protective measure against human-biting ticks in the United States. However, very few studies have addressed the impact of contact with summer-weight permethrin-treated textiles on tick vigor and behavior. Our aim was to generate new knowledge of how permethrin-treated textiles impact nymphal Ixodes scapularis ticks, the primary vectors in the eastern United States of the causative agents of Lyme disease, human anaplasmosis, and human babesiosis...
July 1, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/28754151/identification-of-anaplasma-ovis-appendage-associated-protein-aaap-for-development-of-an-indirect-elisa-and-its-application
#15
Zhenguo Wang, Jifei Yang, Qingli Niu, Kelly A Brayton, Jianxun Luo, Guangyuan Liu, Hong Yin, Zhijie Liu
BACKGROUND: Ovine anaplasmosis is a tick-borne disease that is caused by Anaplasma ovis in sheep and goats. The pathogen is widely distributed in tropical and subtropical regions of the world. At present, diagnosis of the disease mainly depends on microscopy or nucleic acid based molecular tests, although a few serological tests have been applied for the detection of A. ovis infection. RESULTS: Here we describe the identification of an A. ovis protein that is homologous to the A...
July 28, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28749289/clinical-disease-associated-with-anaplasma-phagocytophilum-infection-in-captive-przewalski-s-horses-equus-ferus-przewalskii
#16
Richard R Sim, Priscilla H Joyner, Luis R Padilla, Paul Anikis, Copper Aitken-Palmer
Anaplasma phagocytophilum is a tick-borne pathogen of domestic horses and the causative agent of equine granulocytic anaplasmosis. This case series describes three confirmed cases of clinical anaplasmosis, and a fourth case of presumptive anaplasmosis in Przewalski's horses ( Equus ferus przewalskii) housed at the Smithsonian Conservation Biology Institute from 2008 to 2014. Clinical signs varied among individuals with affected horses exhibiting lethargy, weakness, pyrexia, hypophagia, reluctance to move, or ataxia...
June 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28749278/survey-of-anaplasma-phagocytophilum-antibodies-in-captive-przewalski-s-horses-equus-ferus-przewalskii
#17
Richard R Sim, Luis R Padilla, Priscilla H Joyner, Paul Anikis, Copper Aitken-Palmer
Anaplasma phagocytophilum (formerly Ehrlichia equi ) is a tickborne pathogen of domestic horses and the causative agent of equine granulocytic anaplasmosis. After the occurrence of clinical anaplasmosis in a Przewalski's horse ( Equus ferus przewalskii) housed at the Smithsonian Conservation Biology Institute in 2008, opportunistic serosurveillance of the herd was initiated. From 2008 to 2014, 57 serum samples were collected from 27 individuals (10 males; 17 females). Using indirect immunofluorescent antibody assays for anti- Anaplasma phagocytophilum antibodies, it was determined that prevalence was 53%...
June 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28725639/anaplasma-phagocytophilum-msp4-and-hsp70-proteins-are-involved-in-interactions-with-host-cells-during-pathogen-infection
#18
Marinela Contreras, Pilar Alberdi, Lourdes Mateos-Hernández, Isabel G Fernández de Mera, Ana L García-Pérez, Marie Vancová, Margarita Villar, Nieves Ayllón, Alejandro Cabezas-Cruz, James J Valdés, Snorre Stuen, Christian Gortazar, José de la Fuente
Anaplasma phagocytophilum transmembrane and surface proteins play a role during infection and multiplication in host neutrophils and tick vector cells. Recently, A. phagocytophilum Major surface protein 4 (MSP4) and Heat shock protein 70 (HSP70) were shown to be localized on the bacterial membrane, with a possible role during pathogen infection in ticks. In this study, we hypothesized that A. phagocytophilum MSP4 and HSP70 have similar functions in tick-pathogen and host-pathogen interactions. To address this hypothesis, herein we characterized the role of these bacterial proteins in interaction and infection of vertebrate host cells...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28722620/case-report-infectious-diseases-in-pilgrims-visiting-the-holy-land
#19
Orna Nitzan, Arnon Blum, Esther Marva, Adina Katz, Bat-Sheva Tzadok, Yaarit Nachum-Biala, Gad Baneth, Avi Peretz
Every year Christian pilgrims from around the world visit the holy sites located around the Sea of Galilee. Some become ill during their stay with infectious diseases that were acquired in their country of origin, and are hospitalized at Poriya Medical Center. They pose a diagnostic challenge due to language barriers, the rarity of these infections in Israel, and the fact that diagnostic tests are not readily available. All patient records from 2015 of Holy Land tourists hospitalized at Poriya Medical Center were screened for the diagnosis of imported zoonotic diseases that are not commonly diagnosed in Israel...
August 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28722568/epidemiology-of-spotted-fever-group-rickettsioses-and-acute-undifferentiated-febrile-illness-in-villeta-colombia
#20
Álvaro A Faccini-Martínez, Alejandro Ramírez-Hernández, Christian Barreto, Elkin Forero-Becerra, Diego Millán, Elkin Valbuena, Andrea C Sánchez-Alfonso, Wilson O Imbacuán-Pantoja, Jesús A Cortés-Vecino, Luis J Polo-Terán, Néstor Yaya-Lancheros, Jorge Jácome, Ana M Palomar, Sonia Santibáñez, Aránzazu Portillo, José A Oteo, Marylin Hidalgo
Etiology of acute undifferentiated febrile syndrome (AUFS) is often unknown, leading to inaccurate diagnosis and treatment. Villeta town has been identified as an endemic area for spotted fever group (SFG) rickettsioses but little is known about possible amplifier hosts and other Rickettsia species different from Rickettsia rickettsii. Besides, few studies have approached other AUFS etiologies in the region. We investigated the role of dengue, leptospirosis, rickettsioses, human anaplasmosis, and Q fever as possible causes of AUFS in patients from Villeta...
September 2017: American Journal of Tropical Medicine and Hygiene
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