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https://www.readbyqxmd.com/read/27894074/lsd1-mediates-mycn-control-of-epithelial-mesenchymal-transition-through-silencing-of-metastatic-suppressor-ndrg1-gene
#1
Susanna Ambrosio, Stefano Amente, Carmen D Saccà, Mario Capasso, Raffaele A Calogero, Luigi Lania, Barbara Majello
Neuroblastoma (NB) with MYCN amplification is a highly aggressive and metastatic tumor in children. The high recurrence rate and resistance of NB cells to drugs urgently demands a better therapy for this disease. We have recently found that MYCN interacts with the lysine-specific demethylase 1 (LSD1), a histone modifier that participates in key aspects of gene transcription. In cancer cells, LSD1 contributes to the genetic reprogramming that underlies to Epithelial-Mesenchymal Transition (EMT) and tumor metastasis...
November 22, 2016: Oncotarget
https://www.readbyqxmd.com/read/27831650/critical-genes-of-hepatocellular-carcinoma-revealed-by-network-and-module-analysis-of-rna-seq-data
#2
M-R Yang, Y Zhang, X-X Wu, W Chen
OBJECTIVE: RNA-seq data of hepatocellular carcinoma (HCC) was analyzed to identify critical genes related to the pathogenesis and prognosis. MATERIALS AND METHODS: Three RNA-seq datasets of HCC (GSE69164, GSE63863 and GSE55758) were downloaded from Gene Expression Omnibus (GEO), while another dataset including 54 HCC cases with survival time was obtained from The Cancer Genome Atlas (TCGA). Differentially expressed genes (DEGs) were identified by significant analysis of microarrays (SAM) method using package samr of R...
October 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27830690/-detection-of-novel-genetic-markers-of-susceptibility-to-preeclampsia-based-on-an-analysis-of-the-regulatory-genes-in-the-placental-tissue
#3
V N Serebrova, E A Trifonova, T V Gabidulina, I Yu Bukharina, T A Agarkova, I D Evtushenko, N R Maksimova, V A Stepanov
Regulatory single nucleotide polymorphisms (rSNPs) are the least-studied group of SNP; however, they play an essential role in the development of human pathology by altering the level of candidate genes expression. In this work, we analyzed 29 rSNPs in 17 new candidate genes associated with preeclampsia (PE) according to the analysis of the transcriptome in placental tissue. Three ethnic groups have been studied (yakut, russian, and buryat). We have detected significant associations of PE with eight rSNPs in six differentially expressed genes, i...
September 2016: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/27811999/effects-of-ndrg1-family-proteins-on-photoreceptor-outer-segment-morphology-in-zebrafish
#4
Shimpei Takita, Yasutaka Wada, Satoru Kawamura
Rods and cones are functionally and morphologically distinct. We previously identified N-myc downstream-regulated gene 1b (ndrg1b) in carp as a cone-specific gene. Here, we show that NDRG1b and its paralog, NDRG1a-1, contribute to photoreceptor outer segment (OS) formation in zebrafish. In adult zebrafish photoreceptors, NDRG1a-1 was localized in the entire cone plasma membranes, and also in rod plasma membranes except its OS. NDRG1b was expressed specifically in cones in the entire plasma membranes. In a developing retina, NDRG1a-1 was expressed in the photoreceptor layer, and NDRG1b in the photoreceptor layer plus inner nuclear layer...
November 4, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27793840/targeting-of-pyk2-synergizes-with-egfr-antagonists-in-basal-like-tnbc-and-circumvents-her3-associated-resistance-via-the-nedd4-ndrg1-axis
#5
Nandini Verma, Anna-Katharina Müller, Charu Kothari, Effrosini Panayotopoulou, Amir Kedan, Michael Selitrennik, Gordon B Mills, Lan K Nguyen, Sungyoung Shin, Thomas Karn, Uwe Holtrich, Sima Lev
Triple negative breast cancer (TNBC) is a highly aggressive, heterogeneous disease with poor prognosis and no effective targeted therapies. EGFR is highly expressed in basal-like TNBC and considered as a potential therapeutic target. However, EGFR targeting exerts only marginal clinical benefits, possibly due to activation of compensatory signaling pathways, which are frequently associated with HER3 upregulation. Here we show that concomitant targeting of EGFR and the non-receptor tyrosine kinases PYK2/FAK synergistically inhibits the proliferation of basal-like TNBC cells in vitro and attenuates tumor growth in mouse xenograft model...
October 28, 2016: Cancer Research
https://www.readbyqxmd.com/read/27782193/lipocalin-2-lcn2-is-a-promising-target-for-cholangiocarcinoma-treatment-and-bile-lcn2-level-is-a-potential-cholangiocarcinoma-diagnostic-marker
#6
Kun-Chun Chiang, Ta-Sen Yeh, Ren-Chin Wu, Jong-Hwei S Pang, Chi-Tung Cheng, Shang-Yu Wang, Horng-Heng Juang, Chun-Nan Yeh
Cholangiocarcinoma (CCA) is a devastating disease due to resistance to traditional chemotherapies and radiotherapies. New therapeutic strategies against CCA are urgently needed. This study investigated the role of lipocalin-2 (LCN2) in human cholangiocarcinoma as a potential therapeutic target and diagnostic marker. So far, the role of LCN2 in cancer is still controversial and studies regarding the role of LCN2 in CCA are limited. LCN2 knockdown inhibited CCA cell growth in vitro and in vivo through induction of cell cycle arrest at G0/G1 phases and decreased metastatic potential due to repression of epithelial-mesenchymal transition (EMT)...
October 26, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27716814/low-levels-of-ndrg1-in-nerve-tissue-are-predictive-of-severe-paclitaxel-induced-neuropathy
#7
Raghav Sundar, Anand D Jeyasekharan, Brendan Pang, Richie Chuan Teck Soong, Nesaretnam Barr Kumarakulasinghe, Samuel Guan Wei Ow, Jingshan Ho, Joline Si Jing Lim, David Shao Peng Tan, Einar P V Wilder-Smith, Aishwarya Bandla, Stacey Sze Hui Tan, Bernadette Reyna Asuncion, Zul Fazreen, Michal Marek Hoppe, Thomas Choudary Putti, Lay Mui Poh, Boon Cher Goh, Soo-Chin Lee
INTRODUCTION: Sensory peripheral neuropathy caused by paclitaxel is a common and dose limiting toxicity, for which there are currently no validated predictive biomarkers. We investigated the relationship between the Charcot-Marie-Tooth protein NDRG1 and paclitaxel-induced neuropathy. METHODS/MATERIALS: Archived mammary tissue specimen blocks of breast cancer patients who received weekly paclitaxel in a single centre were retrieved and NDRG1 immunohistochemistry was performed on normal nerve tissue found within the sample...
2016: PloS One
https://www.readbyqxmd.com/read/27711123/language-agnostic-reproducible-data-analysis-using-literate-programming
#8
Boris Vassilev, Riku Louhimo, Elina Ikonen, Sampsa Hautaniemi
A modern biomedical research project can easily contain hundreds of analysis steps and lack of reproducibility of the analyses has been recognized as a severe issue. While thorough documentation enables reproducibility, the number of analysis programs used can be so large that in reality reproducibility cannot be easily achieved. Literate programming is an approach to present computer programs to human readers. The code is rearranged to follow the logic of the program, and to explain that logic in a natural language...
2016: PloS One
https://www.readbyqxmd.com/read/27698340/golgi-phosphoprotein-3-inhibits-the-apoptosis-of-human-glioma-cells-in-part-by-downregulating-n-myc-downstream-regulated-gene-1
#9
Xin Li, Mengyou Li, Xiuli Tian, Qingzhe Li, Qingyang Lu, Qingbin Jia, Lianqun Zhang, Jinqiang Yan, Xueyuan Li, Xingang Li
BACKGROUND Golgi phosphoprotein 3 (GOLPH3) has been reported to be involved in the development of several human cancers. Our previous study showed that GOLPH3 expression in glioma tissues was related to the severity of the malignancy of the cancer. However, the mechanism by which GOLPH3 affects cell apoptosis is largely unknown. The present study was designed to explore the possible mechanism of GOLPH3 in cell apoptosis. MATERIAL AND METHODS To analyze the biological role of GOLPH3 in glioma cells, we used GOLPH3 small interference RNA in apoptosis of glioma cells...
October 4, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27618784/mtor-regulates-the-expression-of-dna-damage-response-enzymes-in-long-lived-snell-dwarf-ghrko-and-pappa-ko-mice
#10
Graham Dominick, Jacqueline Bowman, Xinna Li, Richard A Miller, Gonzalo G Garcia
Studies of the mTOR pathway have prompted speculation that diminished mTOR complex-1 (mTORC1) function may be involved in controlling the aging process. Our previous studies have shown diminished mTORC1 activity in tissues of three long-lived mutant mice: Snell dwarf mice, growth hormone receptor gene disrupted mice (GHRKO), and in this article, mice deficient in the pregnancy-associated protein-A (PAPPA-KO). The ways in which lower mTOR signals slow aging and age-related diseases are, however, not well characterized...
September 13, 2016: Aging Cell
https://www.readbyqxmd.com/read/27589737/the-iron-chelator-dp44mt-effectively-inhibits-human-oral-squamous-cell-carcinoma-cell-growth-in-vitro-and-in-vivo
#11
Jehn-Chuan Lee, Kun-Chun Chiang, Tsui-Hsia Feng, Yu-Jen Chen, Sung-Ting Chuang, Ke-Hung Tsui, Li-Chuan Chung, Horng-Heng Juang
Oral squamous cell carcinoma (OSCC) is a common malignancy with a growing worldwide incidence and prevalence. The N-myc downstream regulated gene (NDRG) family of NDRG1, 2, 3, and mammary serine protease inhibitor (Maspin) gene are well-known modulators in the neoplasia process. Current research has considered iron chelators as new anti-cancer agents; however, the anticancer activities of iron chelators and their target genes in OSCC have not been well investigated. We showed that iron chelators (Dp44mT, desferrioxamine (DFO), and deferasirox) all significantly inhibit SAS cell growth...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27432067/ikk-inhibitor-suppresses-epithelial-mesenchymal-transition-and-induces-cell-death-in-prostate-cancer
#12
Hao Ping, Feiya Yang, Mingshuai Wang, Yinong Niu, Nianzeng Xing
IκB kinase (IKK)/nuclear factor κB (NF-κB) pathway activation is a key event in the acquisition of invasive and metastatic capacities in prostate cancer. A potent small-molecule compound, BMS-345541, was identified as a highly selective IKKα and IKKβ inhibitor to inhibit kinase activity. This study explored the effect of IKK inhibitor on epithelial-mesenchymal transition (EMT), apoptosis and metastasis in prostate cancer. Here, we demonstrate the role of IKK inhibitor reducing proliferation and inducing apoptosis in PC-3 cells...
September 2016: Oncology Reports
https://www.readbyqxmd.com/read/27414086/ndrg1-overexpression-promotes-the-progression-of-esophageal-squamous-cell-carcinoma-through-modulating-wnt-signaling-pathway
#13
Runna Ai, Yulin Sun, Zhimin Guo, Wei Wei, Lanping Zhou, Fang Liu, Denver T Hendricks, Yang Xu, Xiaohang Zhao
N-myc down-regulated gene 1 (NDRG1) has been shown to regulate tumor growth and metastasis in various malignant tumors and also to be dysregulated in esophageal squamous cell carcinoma (ESCC). Here, we show that NDRG1 overexpression (91.9%, 79/86) in ESCC tumor tissues is associated with poor overall survival of esophageal cancer patients. When placed in stable transfectants of the KYSE 30 ESCC cell line generated by lentiviral transduction with the ectopic overexpression of NDRG1, the expression of transducin-like enhancer of Split 2 (TLE2) was decreased sharply, however β-catenin was increased...
September 2016: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/27382987/increase-of-total-nephron-albumin-filtration-and-reabsorption-in-diabetic-nephropathy
#14
Keita P Mori, Hideki Yokoi, Masato Kasahara, Hirotaka Imamaki, Akira Ishii, Takashige Kuwabara, Kenichi Koga, Yukiko Kato, Naohiro Toda, Shoko Ohno, Koichiro Kuwahara, Tomomi Endo, Kazuwa Nakao, Motoko Yanagita, Masashi Mukoyama, Kiyoshi Mori
The amount of albumin filtered through the glomeruli and reabsorbed at the proximal tubules in normal and in diabetic kidneys is debated. The megalin/cubilin complex mediates protein reabsorption, but genetic knockout of megalin is perinatally lethal. To overcome current technical problems, we generated a drug-inducible megalin-knockout mouse line, megalin(lox/lox);Ndrg1-CreER(T2) (iMegKO), in which megalin expression can be shut off at any time by administration of tamoxifen (Tam). Tam administration in adult iMegKO mice decreased the expression of renal megalin protein by 92% compared with that in wild-type C57BL/6J mice and almost completely abrogated renal reabsorption of intravenously injected retinol-binding protein...
July 6, 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/27338835/knockdown-of-ndrg1-promote-epithelial-mesenchymal-transition-of-colorectal-cancer-via-nf-%C3%AE%C2%BAb-signaling
#15
Junli Ma, Quanli Gao, Shan Zeng, Hong Shen
BACKGROUND: NDRG1 plays important roles in tumor growth and metastasis of colorectal cancer (CRC). The relation between NDRG1 and metastatic colorectal cancer (mCRC) has not been identified and the mechanism of NDRG1 involving in mCRC needs to be elucidated. METHODS: Correlations between NDRG1 and clinicopathological characteristics and prognosis of 164 patients with mCRC were evaluated. Sensitivity of NDRG1-knockdown colon cancer cell to irinotecan (CPT-11) was determined by MTT assay...
September 2016: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27334916/copper-and-conquer-copper-complexes-of-di-2-pyridylketone-thiosemicarbazones-as-novel-anti-cancer-therapeutics
#16
Kyung Chan Park, Leyla Fouani, Patric J Jansson, Danson Wooi, Sumit Sahni, Darius J R Lane, Duraippandi Palanimuthu, Hiu Chuen Lok, Zaklina Kovačević, Michael L H Huang, Danuta S Kalinowski, Des R Richardson
Copper is an essential trace metal required by organisms to perform a number of important biological processes. Copper readily cycles between its reduced Cu(i) and oxidised Cu(ii) states, which makes it redox active in biological systems. This redox-cycling propensity is vital for copper to act as a catalytic co-factor in enzymes. While copper is essential for normal physiology, enhanced copper levels in tumours leads to cancer progression. In particular, the stimulatory effect of copper on angiogenesis has been established in the last several decades...
September 1, 2016: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/27215390/metastasis-suppressor-proteins-in-cutaneous-squamous-cell-carcinoma
#17
Onder Bozdogan, Ibrahim Vargel, Tarik Cavusoglu, Ayse A Karabulut, Gurbet Karahan, Nilufer Sayar, Pınar Atasoy, Isik G Yulug
Cutaneous squamous cell carcinomas (cSCCs) are common human carcinomas. Despite having metastasizing capacities, they usually show less aggressive progression compared to squamous cell carcinoma (SCC) of other organs. Metastasis suppressor proteins (MSPs) are a group of proteins that control and slow-down the metastatic process. In this study, we established the importance of seven well-defined MSPs including NDRG1, NM23-H1, RhoGDI2, E-cadherin, CD82/KAI1, MKK4, and AKAP12 in cSCCs. Protein expression levels of the selected MSPs were detected in 32 cSCCs, 6 in situ SCCs, and two skin cell lines (HaCaT, A-431) by immunohistochemistry...
July 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/27154576/ndrg1-controls-gastric-cancer-migration-and-invasion-through-regulating-mmp-9
#18
Xiaojing Chang, Xiaoyang Xu, Xiaoying Xue, Jinguo Ma, Zhenhua Li, Peng Deng, Jing Chen, Shuanglong Zhang, Yu Zhi, Dongqiu Dai
The purpose of this study is to detect the clinical significance of NDRG1 and its relationship with MMP-9 in gastric cancer metastatic progression. 101 cases of gastric cancer specimens were utilized to identify the protein expression of NDRG1 and MMP-9 by immunohistochemistry, their clinical significance was also analyzed. The suppression by siRNA-NDRG1 was employed to detect the role of NDRG1 in gastric cancer progression and its relationship with MMP-9. NDRG1 expression was correlated inversely with the degree of tumor cell differentiation (p < 0...
October 2016: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/26965996/prostate-derived-ets-factor-represses-tumorigenesis-and-modulates-epithelial-to-mesenchymal-transition-in-bladder-carcinoma-cells
#19
Ke-Hung Tsui, Yu-Hsiang Lin, Li-Chuan Chung, Sung-Ting Chuang, Tsui-Hsia Feng, Kun-Chun Chiang, Phei-Lang Chang, Chi-Ju Yeh, Horng-Heng Juang
Prostate-derived Ets (E-twenty six) factor (PDEF), an epithelium-specific member of the Ets family of transcription factors, has been shown to play a role in suppressing the development of many epithelium-derived cancers such as prostate and breast cancer. It is not clear, however, whether PDEF is involved in the development or progression of bladder cancer. In a comparison between normal urothelium and bladder tumor tissue, we identified significant decreases of PDEF in the tumor tissue. Further, the immunohistochemistry assays indicated a significantly higher immunostaining of PDEF in low-grade bladder tumors...
May 28, 2016: Cancer Letters
https://www.readbyqxmd.com/read/26965928/the-potential-of-deferasirox-as-a-novel-therapeutic-modality-in-gastric-cancer
#20
Jung Hye Choi, Jung Soon Kim, Young Woong Won, Jieun Uhm, Byeong Bae Park, Young Yiul Lee
BACKGROUND: Iron is a crucial element for cell proliferation, growth, and metabolism. However, excess iron and altered iron metabolism are both associated with tumor initiation and tumor growth. Deferasirox is an oral iron chelator. Although some studies have indicated that deferasirox is a promising candidate for anti-cancer therapies, its effectiveness against gastric cancer has not yet been determined. This study was conducted to determine whether deferasirox exerts anti-tumor effects in gastric cancer cell lines and whether deferasirox and cisplatin act synergistically...
2016: World Journal of Surgical Oncology
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