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Terlipressine shock

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https://www.readbyqxmd.com/read/27931650/effect-of-non-adrenergic-vasopressors-on-macro-and-microvascular-coupling-in-distributive-shock
#1
REVIEW
M Hessler, T G Kampmeier, S Rehberg
The present review initially describes the rationale for the use of non-adrenergic vasopressors in the treatment of distributive shock and then provides an overview of the individual vasopressin-receptor agonists, namely arginine vasopressin, terlipressin, and selepressin. Following a brief summary of their current use in clinical practice, the present review focuses on the influence of vasopressin-receptor agonists on macro- and microvascular coupling, also referred to as hemodynamic coherence. On the basis of the current evidence from experimental and clinical studies, vasopressin-receptor agonists do not negatively influence macro- and microvascular coupling as compared to the standard therapy with norepinephrine, when used in established treatment regimes...
December 2016: Best Practice & Research. Clinical Anaesthesiology
https://www.readbyqxmd.com/read/27766555/safety-and-efficacy-of-terlipressin-in-pediatric-distributive-shock-a-retrospective-analysis-in-20-children
#2
Jörg Michel, Michael Hofbeck, Gina Spiller, Hanna Renk, Matthias Kumpf, Felix Neunhoeffer
INTRODUCTION: Data are still lacking about the use of terlipressin or vasopressin in the treatment of pediatric patients who are in a state of therapy-refractory shock. OBJECTIVE: The aim of this study was to evaluate the effect of terlipressin on hemodynamics in children with distributive shock and to describe any severe side effects. METHODS: Consecutive patients (n = 20) with catecholamine-resistant distributive shock who were treated with terlipressin were retrospectively enrolled in this study...
October 20, 2016: Paediatric Drugs
https://www.readbyqxmd.com/read/27633962/a-randomized-trial-comparing-terlipressin-and-noradrenaline-in-patients-with-cirrhosis-and-septic-shock
#3
Ashok Choudhury, Chandan K Kedarisetty, Chitranshu Vashishtha, Deepak Saini, Sachin Kumar, Rakhi Maiwall, Manoj K Sharma, Ajeet S Bhadoria, Guresh Kumar, Yogendra K Joshi, Shiv K Sarin
BACKGROUND & AIMS: The choice of vasopressor for treating cirrhosis with septic shock is unclear. While noradrenaline in general is the preferred vasopressor, terlipressin improves microcirculation in addition to vasopressor action in non-cirrhotics. We compared the efficacy and safety of noradrenaline and terlipressin in cirrhotics with septic shock. PATIENTS AND METHODS: Cirrhotics with septic shock underwent open label randomization to receive either terlipressin (n=42) or noradrenaline (n=42) infusion at a titrated dose...
September 16, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/26612478/microcirculatory-alterations-during-haemorrhagic-shock-and-after-resuscitation-in-a-paediatric-animal-model
#4
Rafael González, Javier Urbano, Jorge López, Maria J Solana, Marta Botrán, Ana García, Sarah N Fernández, Jesús López-Herce
BACKGROUND: Haemorrhagic shock is frequent in paediatric trauma patients and after cardiac surgery, especially after cardiopulmonary bypass. It has demonstrated to be related to bad outcome. OBJECTIVES: To evaluate changes on microcirculatory parameters during haemorrhagic shock and resuscitation in a paediatric animal model. To determine correlation between microcirculatory parameters and other variables routinely used in the monitoring of haemorrhagic shock. METHODS: Experimental study on 17 Maryland pigs...
February 2016: Injury
https://www.readbyqxmd.com/read/26558621/non-adrenergic-vasopressors-in-patients-with-or-at-risk-for-vasodilatory-shock-a-systematic-review-and-meta-analysis-of-randomized-trials
#5
REVIEW
Alessandro Belletti, Mario Musu, Simona Silvetti, Omar Saleh, Laura Pasin, Fabrizio Monaco, Ludhmila A Hajjar, Evgeny Fominskiy, Gabriele Finco, Alberto Zangrillo, Giovanni Landoni
INTRODUCTION: Hypotensive state is frequently observed in several critical conditions. If an adequate mean arterial pressure is not promptly restored, insufficient tissue perfusion and organ dysfunction may develop. Fluids and catecholamines are the cornerstone of critical hypotensive states management. Catecholamines side effects such as increased myocardial oxygen consumption and development of arrhythmias are well known. Thus, in recent years, interest in catecholamine-sparing agents such as vasopressin, terlipressin and methylene blue has increased; however, few randomized trials, mostly with small sample sizes, have been performed...
2015: PloS One
https://www.readbyqxmd.com/read/26253455/effects-of-terlipressin-on-patients-with-sepsis-via-improving-tissue-blood-flow
#6
RANDOMIZED CONTROLLED TRIAL
Xudong Xiao, Jie Zhang, Yaoli Wang, Jian Zhou, Yu Zhu, Dongpo Jiang, Liangming Liu, Tao Li
Terlipressin (TP), an analog of arginine vasopressin, was reported beneficial in sepsis patients when combined use with norepinephrine (NE), but the undetermined action, mechanism, and safety limited it to become the first-line vasopressor for sepsis patients. With 32 septic shock patients, we investigated the effects of a small dose of TP (1.3 μg/kg/h) on hemodynamic, tissue blood flow, vital organ function, acid-base balance, and coagulation function to systemically know the beneficial effect and side effects of TP on septic shock...
January 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/26237037/vasopressors-for-the-treatment-of-septic-shock-systematic-review-and-meta-analysis
#7
REVIEW
Tomer Avni, Adi Lador, Shaul Lev, Leonard Leibovici, Mical Paul, Alon Grossman
OBJECTIVE: International guidelines recommend dopamine or norepinephrine as first-line vasopressor agents in septic shock. Phenylephrine, epinephrine, vasopressin and terlipressin are considered second-line agents. Our objective was to assess the evidence for the efficiency and safety of all vasopressors in septic shock. METHODS: Systematic review and meta-analysis. We searched electronic database of MEDLINE, CENTRAL, LILACS and conference proceedings up to June 2014...
2015: PloS One
https://www.readbyqxmd.com/read/26203253/vasopressors-in-septic-shock-a-systematic-review-and-network-meta-analysis
#8
Feihu Zhou, Zhi Mao, Xiantao Zeng, Hongjun Kang, Hui Liu, Liang Pan, Peter C Hou
OBJECTIVE: Vasopressor agents are often prescribed in septic shock. However, their effects remain controversial. We conducted a systematic review and Bayesian network meta-analysis to compare the effects among different types of vasopressor agents. DATA SOURCES: We searched for relevant studies in PubMed, Embase, and the Cochrane Library databases from database inception until December 2014. STUDY SELECTION: Randomized controlled trials in adults with septic shock that evaluated different vasopressor agents were selected...
2015: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/25888229/effects-of-terlipressin-as-early-treatment-for-protection-of-brain-in-a-model-of-haemorrhagic-shock
#9
RANDOMIZED CONTROLLED TRIAL
Keila Kazue Ida, Denise Aya Otsuki, Adolfo Toshiro Cotarelli Sasaki, Emilyn Silva Borges, Letícia Urbano Cardoso Castro, Talita Rojas Sanches, Maria-Heloisa Massola Shimizu, Lúcia Conceição Andrade, José-Otávio Costa Auler, Alex Dyson, Kenneth John Smith, Joel Avancini Rocha Filho, Luiz-Marcelo Sá Malbouisson
INTRODUCTION: We investigated whether treatment with terlipressin during recovery from hypotension due to haemorrhagic shock (HS) is effective in restoring cerebral perfusion pressure (CPP) and brain tissue markers of water balance, oxidative stress and apoptosis. METHODS: In this randomised controlled study, animals undergoing HS (target mean arterial pressure (MAP) 40 mmHg for 30 minutes) were randomised to receive lactated Ringer's solution (LR group; n =14; volume equal to three times the volume bled), terlipressin (TERLI group; n =14; 2-mg bolus), no treatment (HAEMO group; n =12) or sham (n =6)...
2015: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/25794276/comparison-of-normal-saline-hypertonic-saline-albumin-and-terlipressin-plus-hypertonic-saline-albumin-in-an-infant-animal-model-of-hypovolemic-shock
#10
COMPARATIVE STUDY
Javier Urbano, Rafael González, Jorge López, María J Solana, José M Bellón, Marta Botrán, Ana García, Sarah N Fernández, Jesús López-Herce
INTRODUCTION: In series of cases and animal models suffering hemorrhagic shock, the use of vasopressors has shown potential benefits regarding hemodynamics and tissue perfusion. Terlipressin is an analogue of vasopressin with a longer half-life that can be administered by bolus injection. We have previously observed that hypertonic albumin improves resuscitation following controlled hemorrhage in piglets. The aim of the present study was to analyze whether the treatment with the combination of terlipressin and hypertonic albumin can produce better hemodynamic and tissular perfusion parameters than normal saline or hypertonic albumin alone at early stages of hemorrhagic shock in an infant animal model...
2015: PloS One
https://www.readbyqxmd.com/read/25777915/effects-of-terlipressin-as-early-treatment-for-protection-of-brain-in-a-model-of-haemorrhagic-shock
#11
Keila Kazue Ida, Denise Aya Otsuki, Adolfo Toshiro Cotarelli Sasaki, Emilyn Silva Borges, Letícia Urbano Cardoso Castro, Talita Rojas Sanches, Maria-Heloisa Massola Shimizu, Lúcia Conceição Andrade, José-Otávio Costa Auler, Alex Dyson, Kenneth John Smith, Joel Avancini Rocha Filho, Luiz-Marcelo Sá Malbouisson
INTRODUCTION: We investigated whether treatment with terlipressin during recovery from hypotension due to haemorrhagic shock (HS) is effective to restore cerebral perfusion pressure (CPP) and brain tissue markers of water balance, oxidative stress and apoptosis. METHODS: In this randomised controlled study, animals undergoing HS (target mean arterial pressure (MAP) 40 mm Hg for 30 minutes) were randomized to receive lactated Ringer's solution (LR; n = 14; 3x volume bled), terlipressin (TERLI; n = 14; 2 mg bolus), no treatment (HAEMO group; n = 12) or sham (n = 6)...
December 2015: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/25769491/beneficial-and-side-effects-of-arginine-vasopressin-and-terlipressin-for-septic-shock
#12
Xudong Xiao, Yu Zhu, Danyang Zhen, Xiao Ming Chen, Wu Yue, Liangming Liu, Tao Li
Arginine vasopressin (AVP) and its analog, terlipressin (TP), were all demonstrated beneficial for septic shock. What advantages and disadvantages that AVP and TP have for septic shock as well as the mechanism, however, are not completely known. With cecal ligation and puncture-induced septic shock rats and lipopolysaccharide-induced septic shock rabbits, we systematically compared the beneficial and side effects of AVP and TP, in septic shock and the sex difference, and investigated their relationship to Rho kinase and calcium sensitivity...
May 15, 2015: Journal of Surgical Research
https://www.readbyqxmd.com/read/25316644/-terlipressin-as-a-new-therapeutic-agent-in-septic-shock
#13
Valter Nilton Felix
BACKGROUND AND OBJECTIVES: The hemodynamic support of sepsis is now formulated trying to insert terlipressin as salvage drug in catecholamine resistant shock, justifying a broad critical analysis. CONTENTS: The analysis included hemodynamic therapies with defined specific goals and new recommendations for fluid resuscitation, vasopressor therapy, and inotropic therapy of septic in adult and pediatric patients. CONCLUSIONS: Terlipressin appears as a new but controversial alternative for vasopressor therapy in sepsis...
June 2006: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/25254206/vasopressin-in-hemorrhagic-shock-a-systematic-review-and-meta-analysis-of-randomized-animal-trials
#14
REVIEW
Andrea Pasquale Cossu, Paolo Mura, Lorenzo Matteo De Giudici, Daniela Puddu, Laura Pasin, Maurizio Evangelista, Theodoros Xanthos, Mario Musu, Gabriele Finco
OBJECTIVE: The latest European guidelines for the management of hemorrhagic shock suggest the use of vasopressors (norepinephrine) in order to restore an adequate mean arterial pressure when fluid resuscitation therapy fails to restore blood pressure. The administration of arginine vasopressin (AVP), or its analogue terlipressin, has been proposed as an alternative treatment in the early stages of hypovolemic shock. DESIGN: A meta-analysis of randomized controlled animal trials...
2014: BioMed Research International
https://www.readbyqxmd.com/read/25133044/renal-dysfunction-in-patients-with-cirrhosis-where-do-we-stand
#15
REVIEW
Chrysoula Pipili, Evangelos Cholongitas
Patients with cirrhosis and renal failure are high-risk patients who can hardly be grouped to form precise instructions for diagnosis and treatment. When it comes to evaluate renal function in patients with cirrhosis, determination of acute kidney injury (AKI), chronic kidney disease (CKD) or AKI on CKD should be made. First it should be excluded the prerenal causes of AKI. All cirrhotic patients should undergo renal ultrasound for measurement of renal resistive index in every stage of liver dysfunction and urine microscopy for differentiation of all causes of AKI...
August 6, 2014: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/24759799/a-comparison-of-vasopressin-terlipressin-and-lactated-ringers-for-resuscitation-of-uncontrolled-hemorrhagic-shock-in-an-animal-model
#16
Chien-Chang Lee, Meng-Tse Gabriel Lee, Shy-Shin Chang, Si-Huei Lee, Yu-Chi Huang, Chia-Hung Yo, Shih-Hao Lee, Shyr-Chyr Chen
AIM: The aim of this study is to compare the effect of lactated ringer (LR), vasopressin (Vaso) or terlipressin (Terli) on uncontrolled hemorrhagic shock (UHS) in rats. METHODS: 48 rats were divided into four treatment groups for UHS study. Vaso group was given bolus vasopressin (0.8 U/kg); the Terli group was given bolus terlipressin (15 mcg/kg); LR group was given LR and the sham group was not given anything. Mean arterial pressure (MAP), serum lactate level, plasma cytokine levels, lung injury and mortality are investigated for these different treatment groups...
2014: PloS One
https://www.readbyqxmd.com/read/24582066/effects-of-terlipressin-on-microcirculation-of-small-bowel-mesentery-in-rats-with-endotoxic-shock
#17
Xiaohua Qiu, Yanxia Huang, Jingyuan Xu, Haibo Qiu, Yi Yang
BACKGROUND: Septic shock is still related to unacceptably high morbidity and mortality. Microcirculatory alteration has been demonstrated to be one important reason associated with this evolution. Vasoactive drugs are often used to restore adequate arterial pressure and tissue perfusion in septic shock. To define the roles of different drugs, the effects of terlipressin (TP) on the microcirculation of small bowel mesentery in rats with endotoxic shock were evaluated and compared with those of norepinephrine (NE)...
May 15, 2014: Journal of Surgical Research
https://www.readbyqxmd.com/read/24151551/therapeutic-strategies-for-high-dose-vasopressor-dependent-shock
#18
REVIEW
Estevão Bassi, Marcelo Park, Luciano Cesar Pontes Azevedo
There is no consensual definition of refractory shock. The use of more than 0.5 mcg/kg/min of norepinephrine or epinephrine to maintain target blood pressure is often used in clinical trials as a threshold. Nearly 6% of critically ill patients will develop refractory shock, which accounts for 18% of deaths in intensive care unit. Mortality rates are usually greater than 50%. The assessment of fluid responsiveness and cardiac function can help to guide therapy, and inotropes may be used if hypoperfusion signs persist after initial resuscitation...
2013: Critical Care Research and Practice
https://www.readbyqxmd.com/read/24103711/reducing-mortality-in-acute-kidney-injury-patients-systematic-review-and-international-web-based-survey
#19
REVIEW
Giovanni Landoni, Tiziana Bove, Andrea Székely, Marco Comis, Reitze N Rodseth, Daniela Pasero, Martin Ponschab, Marta Mucchetti, Tiziana Bove, Maria L Azzolini, Fabio Caramelli, Gianluca Paternoster, Giovanni Pala, Luca Cabrini, Daniele Amitrano, Giovanni Borghi, Antonella Capasso, Claudia Cariello, Anna Carpanese, Paolo Feltracco, Leonardo Gottin, Rosetta Lobreglio, Lorenzo Mattioli, Fabrizio Monaco, Francesco Morgese, Mario Musu, Laura Pasin, Antonio Pisano, Agostino Roasio, Gianluca Russo, Giorgio Slaviero, Nicola Villari, Annalisa Vittorio, Mariachiara Zucchetti, Fabio Guarracino, Andrea Morelli, Vincenzo De Santis, Paolo A Del Sarto, Antonio Corcione, Marco Ranieri, Gabriele Finco, Alberto Zangrillo, Rinaldo Bellomo
OBJECTIVE: To identify all interventions that increase or reduce mortality in patients with acute kidney injury (AKI) and to establish the agreement between stated beliefs and actual practice in this setting. DESIGN AND SETTING: Systematic literature review and international web-based survey. PARTICIPANTS: More than 300 physicians from 62 countries. INTERVENTIONS: Several databases, including MEDLINE/PubMed, were searched with no time limits (updated February 14, 2012) to identify all the drugs/techniques/strategies that fulfilled all the following criteria: (a) published in a peer-reviewed journal, (b) dealing with critically ill adult patients with or at risk for acute kidney injury, and (c) reporting a statistically significant reduction or increase in mortality...
December 2013: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/23905079/vasopressin-vs-terlipressin-in-treatment-of-refractory-shock
#20
G Scarpati, O Piazza
Arginine vasopressin (AVP) and its synthetic, long-acting analog terlipressin (TP) are potent alternative vasoconstrictors in the treatment of septic patients with catecholamine-refractive vasodilatatory shock. Recent clinical data suggest that early administration of AVP analogues may be advantageous compared to a last resort therapy. However, it is still unknown whether vasopressin and terlipressin are equally effective for hemodynamic support in shock. Despite important pharmacological differences between the two drugs the use of either substance is determined mainly by local availability and institutional inventory...
January 2013: Translational Medicine @ UniSa
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