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https://www.readbyqxmd.com/read/28098939/a-systematic-review-of-economic-evaluations-of-treatments-for-patients-with-epilepsy
#1
REVIEW
Ben F M Wijnen, Ghislaine A P G van Mastrigt, Silvia M A A Evers, Olga Gershuni, Danielle A J E Lambrechts, Marian H J M Majoie, Debby Postulart, Bert A P Aldenkamp, Reina J A de Kinderen
The increasing number of treatment options and the high costs associated with epilepsy have fostered the development of economic evaluations in epilepsy. It is important to examine the availability and quality of these economic evaluations and to identify potential research gaps. As well as looking at both pharmacologic (antiepileptic drugs [AEDs]) and nonpharmacologic (e.g., epilepsy surgery, ketogenic diet, vagus nerve stimulation) therapies, this review examines the methodologic quality of the full economic evaluations included...
January 18, 2017: Epilepsia
https://www.readbyqxmd.com/read/28098427/emergence-of-mania-in-two-middle-aged-patients-with-a-history-of-unipolar-treatment-refractory-depression-receiving-vagus-nerve-stimulation
#2
Naji C Salloum, Marie C Walker, Sunil Gangwani, Charles R Conway
OBJECTIVES: We report on two patients who experienced emergence of full manic symptoms while receiving vagal nerve stimulation (VNS). METHODS: Two patients, both with a well-documented and verified history of longstanding unipolar depression, were initiated on VNS for treatment of their severe major depressive episodes. RESULTS: The two patients had emergence of full manic symptoms after 8 and 9 months of VNS, respectively. Manic symptoms were adequately managed with standard treatments (mood stabilizer and electroconvulsive therapy) and VNS was continued in the two subjects for up to 5 years without any further occurrences of manic/hypomanic episodes...
January 18, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28091707/gastric-distension-causes-changes-in-heart-rate-and-arterial-blood-pressure-by-affecting-the-crosstalk-between-vagal-and-splanchnic-systems-in-anesthetised-rats
#3
Maurizio Sabbatini, Elena Grossini, Claudio Molinari, David A S G Mary, Giovanni Vacca, Mario Cannas
Various hindbrain nuclei have been demonstrated to be involved in the control of the cardiovascular reflexes elicited by both non-noxious and noxious gastric distension, through parasympathetic and sympathetic activation. The different role played by the branches of autonomic nervous system in exerting these effects and their crosstalk in relation to low-/high-pressure distension rate has not been examined yet. Therefore, in the present work, monolateral and bilateral vagotomy and splanchnicotomy were performed in anesthetised rats to analyse the involvement of hindbrain nuclei in haemodynamic changes caused by gastric distension at high (80 mmHg) and low (15 mmHg) pressure...
January 13, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28079431/vagus-nerve-stimulation-in-intractable-epilepsy-associated-with-scn1a-gene-abnormalities
#4
Stephen P Fulton, Kate Van Poppel, Amy L McGregor, Basanagoud Mudigoudar, James W Wheless
Mutations in the SCN1A gene cause a spectrum of epilepsy syndromes. There are 2 syndromes that are on the severe end of this spectrum. The classic severe form, Dravet syndrome, is an epileptic encephalopathy of childhood, causing cognitive decline as well as intractable seizures. Severe Myoclonic Epilepsy of Infancy-Borderline (SMEIB) is a term used to include cases with similar severities as those with Dravet syndrome, but lacking a single feature of classic severe myoclonic epilepsy of infancy. Vagus nerve stimulation is a nonpharmacologic treatment for intractable epilepsy...
January 1, 2017: Journal of Child Neurology
https://www.readbyqxmd.com/read/28070485/vagus-nerve-stimulation-for-genetic-epilepsy-with-febrile-seizures-plus-gefs-accompanying-seizures-with-impaired-consciousness
#5
Ryosuke Hanaya, Fajar H Niantiarno, Yumi Kashida, Hiroshi Hosoyama, Shinsuke Maruyama, Toshiaki Otsubo, Kazumi Tanaka, Atsushi Ishii, Shinichi Hirose, Kazunori Arita
Genetic epilepsy with febrile seizures plus (GEFS(+)) is characterized by childhood-onset epilepsy syndrome. It involves febrile seizures and a variety of afebrile epileptic seizure types within the same pedigree with autosomal-dominant inheritance. Approximately 10% of individuals with GEFS(+) harbor SCN1A, a gene mutation in one of the voltage-gated sodium channel subunits. Considerably less common are focal epilepsies including complex partial seizures. We report vagus nerve stimulation (VNS) in a 6-year-old girl with GEFS(+) who exhibited refractory generalized tonic-clonic seizures and complex partial seizures...
2017: Epilepsy & Behavior Case Reports
https://www.readbyqxmd.com/read/28065837/vagal-regulation-of-group-3-innate-lymphoid-cells-and-the-immunoresolvent-pctr1-controls-infection-resolution
#6
Jesmond Dalli, Romain A Colas, Hildur Arnardottir, Charles N Serhan
Uncovering mechanisms that control immune responses in the resolution of bacterial infections is critical for the development of new therapeutic strategies that resolve infectious inflammation without unwanted side effects. We found that disruption of the vagal system in mice delayed resolution of Escherichia coli infection. Dissection of the right vagus decreased peritoneal group 3 innate lymphoid cell (ILC3) numbers and altered peritoneal macrophage responses. Vagotomy resulted in an inflammatory peritoneal lipid mediator profile characterized by reduced concentrations of pro-resolving mediators, including the protective immunoresolvent PCTR1, along with elevated inflammation-initiating eicosanoids...
January 17, 2017: Immunity
https://www.readbyqxmd.com/read/28065827/gastric-bypass-surgery-recruits-a-gut-ppar-%C3%AE-striatal-d1r-pathway-to-reduce-fat-appetite-in-obese-rats
#7
Mohammed K Hankir, Florian Seyfried, Constantin A Hintschich, Thi-Ai Diep, Karen Kleberg, Mathias Kranz, Winnie Deuther-Conrad, Luis A Tellez, Michael Rullmann, Marianne Patt, Jens Teichert, Swen Hesse, Osama Sabri, Peter Brust, Harald S Hansen, Ivan E de Araujo, Ute Krügel, Wiebke K Fenske
Bariatric surgery remains the single most effective long-term treatment modality for morbid obesity, achieved mainly by lowering caloric intake through as yet ill-defined mechanisms. Here we show in rats that Roux-en-Y gastric bypass (RYGB)-like rerouting of ingested fat mobilizes lower small intestine production of the fat-satiety molecule oleoylethanolamide (OEA). This was associated with vagus nerve-driven increases in dorsal striatal dopamine release. We also demonstrate that RYGB upregulates striatal dopamine 1 receptor (D1R) expression specifically under high-fat diet feeding conditions...
January 2, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28065795/rational-identification-of-a-novel-soy-derived-anxiolytic-like-undecapeptide-acting-via-gut-brain-axis-after-oral-administration
#8
Ami Ota, Akane Yamamoto, Saeko Kimura, Yukiha Mori, Takafumi Mizushige, Yoshiki Nagashima, Masaru Sato, Hideyuki Suzuki, Saori Odagiri, Daisuke Yamada, Masayuki Sekiguchi, Keiji Wada, Ryuhei Kanamoto, Kousaku Ohinata
Here we found that the chymotryptic digest of soy β-conglycinin, a major storage protein, exhibited anxiolytic-like effects in mice. We then searched for anxiolytic-like peptides in the digest. Based on a comprehensive peptide analysis of the chymotryptic digest by high performance liquid chromatograph connected to an LTQ Orbitrap mass spectrometer and the structure-activity relationship of known peptides, we explored anxiolytic-like peptides present in the digest. FLSSTEAQQSY, which corresponds to 323-333 of the β-conglycinin α subunit [βCGα(323-333)] emerged as a candidate...
January 5, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28054557/kilohertz-frequency-nerve-block-enhances-anti-inflammatory-effects-of-vagus-nerve-stimulation
#9
Yogi A Patel, Tarun Saxena, Ravi V Bellamkonda, Robert J Butera
Efferent activation of the cervical vagus nerve (cVN) dampens systemic inflammatory processes, potentially modulating a wide-range of inflammatory pathological conditions. In contrast, afferent cVN activation amplifies systemic inflammatory processes, leading to activation of the hypothalamic-pituitary-adrenal (HPA) axis, the sympathetic nervous system through the greater splanchnic nerve (GSN), and elevation of pro-inflammatory cytokines. Ideally, to clinically implement anti-inflammatory therapy via cervical vagus nerve stimulation (cVNS) one should selectively activate the efferent pathway...
January 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28053029/mutant-%C3%AE-synuclein-overexpression-induces-stressless-pacemaking-in-vagal-motoneurons-at-risk-in-parkinson-s-disease
#10
Efrat Lasser-Katz, Alon Simchovitz, Wei-Hua Chiu, Wolfgang H Oertel, Ronit Sharon, Hermona Soreq, Jochen Roeper, Joshua A Goldberg
: α-Synuclein overexpression (ASOX) drives the formation of toxic aggregates in neurons vulnerable in Parkinson's disease (PD), including dopaminergic neurons of the substantia nigra (SN) and cholinergic neurons of the dorsal motor nucleus of the vagus (DMV). Just as these populations differ in when they exhibit α-synucleinopathies during PD pathogenesis, they could also differ in their physiological responses to ASOX. An ASOX-mediated hyperactivity of SN dopamine neurons, which was caused by oxidative dysfunction of Kv4...
January 4, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28052645/double-labeling-of-vagal-preganglionic-and-sympathetic-postganglionic-fibers-in-celiac-ganglion-superior-mesenteric-arteries-and-myenteric-plexus
#11
Shi-Jane Ting, Chih-Kuan Kao, Feng-Bin Wang
Sympathetic efferents regulate the “fight-or-flight” response and sympathetic and vagal fibers have been suggested to retrogradely and centrally spread pathogens associated with Parkinson’s disease. To examine the arrangement of the vagal and sympathetic motor fibers in the celiac ganglion (CG), gastrointestinal tract, and along the superior mesenteric artery and its sub-branches, we double-labeled the vagal efferents by injecting Dextran-Texas Red into the dorsal motor nucleus of the vagus and the sympathetic postganglionics with tyrosine hydroxylase immunohistochemistry in male Sprague-Dawley rats (n = 18)...
28, 2017: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/28051128/electroacupuncture-treatment-partly-promotes-the-recovery-time-of-postoperative-ileus-by-activating-the-vagus-nerve-but-not-regulating-local-inflammation
#12
Jun-Fan Fang, Jian-Qiao Fang, Xiao-Mei Shao, Jun-Ying Du, Yi Liang, Wen Wang, Zhe Liu
Postoperative ileus (POI) after abdominal surgery significantly lowers the life quality of patients and increase hospital costs. However, few treatment strategies have successfully shortened the duration of POI. Electroacupuncture (EA) is a modern way of administering acupuncture and widely used in various gastrointestinal (GI) diseases in the world. Here, we studied the effect of EA on POI and its underlying mechanisms. Intestinal manipulation resulted in significant delays of GI transit, colonic transit and gastric emptying...
January 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28045306/examining-the-association-between-perceived-discrimination-and-heart-rate-variability-in-african-americans
#13
LaBarron K Hill, Lori S Hoggard, Ashley S Richmond, DeLeon L Gray, Dewayne P Williams, Julian F Thayer
OBJECTIVE: Previous research attempting to delineate the role of discrimination in racial/ethnic disparities in hypertension has focused largely on blood pressure, which is chiefly governed by the sympathetic branch of the autonomic nervous system. Consequently, few studies have considered the role of the parasympathetic branch and particularly its regulation of the heart via the vagus nerve. METHOD: In the present cross-sectional study, we employed hierarchical linear regressions to examine associations between perceived ethnic discrimination and resting heart rate variability (HRV), an important biomarker of parasympathetic cardiac modulation and overall health, in a sample (N = 103) of young, healthy African American participants (58% female, Mage = 19...
January 2017: Cultural Diversity & Ethnic Minority Psychology
https://www.readbyqxmd.com/read/28044208/hepatic-vagus-nerve-regulates-kupffer-cell-activation-via-%C3%AE-7-nicotinic-acetylcholine-receptor-in-nonalcoholic-steatohepatitis
#14
Takahiro Nishio, Kojiro Taura, Keiko Iwaisako, Yukinori Koyama, Kazutaka Tanabe, Gen Yamamoto, Yukihiro Okuda, Yoshinobu Ikeno, Kenji Yoshino, Yosuke Kasai, Masayuki Okuno, Satoru Seo, Takaki Sakurai, Masataka Asagiri, Etsuro Hatano, Shinji Uemoto
BACKGROUND: Nonalcoholic fatty liver disease ranges from simple steatosis to nonalcoholic steatohepatitis (NASH). Kupffer cells play a central role in promoting hepatic inflammation, which leads to the development of NASH. We investigated the anti-inflammatory effect of hepatic vagus-mediated stimulation of the α7 nicotinic acetylcholine receptor (α7nAChR) on Kupffer cells in NASH pathogenesis. METHODS: Wild-type (WT) mice undergoing hepatic vagotomy (HV) were fed a methionine- and choline-deficient (MCD) diet for 1 week...
January 2, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28035935/altered-gut-microbiome-composition-and-tryptic-activity-of-the-5xfad-alzheimer-s-mouse-model
#15
Carolin Brandscheid, Florian Schuck, Sven Reinhardt, Karl-Herbert Schäfer, Claus U Pietrzik, Marcus Grimm, Tobias Hartmann, Andreas Schwiertz, Kristina Endres
The regulation of physiological gut functions such as peristalsis or secretion of digestive enzymes by the central nervous system via the Nervus vagus is well known. Recent investigations highlight that pathological conditions of neurological or psychiatric disorders might directly interfere with the autonomous neuronal network of the gut - the enteric nervous system, or even derive from there. By using a murine Alzheimer's disease model, we investigated a potential influence of disease-associated changes on gastrointestinal properties...
December 30, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28032928/integrity-of-the-ganglionated-plexi-is-essential-to-parasympathetic-innervation-of-the-atrioventricular-node-by-the-right-vagus-nervez
#16
Olivier Xhaet, Luc DE Roy, Mariana Floria, Olivier Deceuninck, Dominique Blommaert, Fabien Dormal, Elisabeth Ballant, Mark LA Meir
INTRODUCTION: Radiofrequency isolation of pulmonary vein can be accompanied by transient sinus bradycardia or atrioventricular nodal (AVN) block, suggesting an influence on vagal cardiac innervation. However, the importance of the atrial fat pads in relation with the vagal innervation of AVN in humans remains largely unknown. This article is protected by copyright. All rights reserved The aim of this study was to evaluate the role of ganglionated plexi (GP) in the innervation of the AVN by the right vagus nerve...
December 29, 2016: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28030999/seizure-control-in-a-computational-model-using-a-reinforcement-learning-stimulation-paradigm
#17
Vivek Nagaraj, Andrew Lamperski, Theoden I Netoff
Neuromodulation technologies such as vagus nerve stimulation and deep brain stimulation, have shown some efficacy in controlling seizures in medically intractable patients. However, inherent patient-to-patient variability of seizure disorders leads to a wide range of therapeutic efficacy. A patient specific approach to determining stimulation parameters may lead to increased therapeutic efficacy while minimizing stimulation energy and side effects. This paper presents a reinforcement learning algorithm that optimizes stimulation frequency for controlling seizures with minimum stimulation energy...
November 2, 2016: International Journal of Neural Systems
https://www.readbyqxmd.com/read/28029582/obstructive-sleep-apnoea-is-frequent-in-patients-with-type-1-diabetes
#18
Anne Margareta Banghoej, Henriette Holst Nerild, Peter Lommer Kristensen, Ulrik Pedersen-Bjergaard, Jesper Fleischer, Andreas Emil Kryger Jensen, Michael Laub, Birger Thorsteinsson, Lise Tarnow
AIM: Obstructive Sleep Apnoea (OSA) is frequent in patients with type 2 diabetes. The aim of this study is to evaluate prevalence of OSA in patients with type 1 diabetes. METHODS: In a cross-sectional design, all patients with type 1 diabetes attending the outpatient clinic were offered screening for OSA for one night with the ApneaLink+ home-monitoring device. OSA was classified by the Apnoea-Hypopnea index (AHI; apnoeas/hypopneas per hour sleep). Symptoms of OSA were scored using the Epworth Sleepiness Score...
January 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28017263/effects-of-short-and-prolonged-transcutaneous-vagus-nerve-stimulation-on-heart-rate-variability-in-healthy-subjects
#19
M De Couck, R Cserjesi, R Caers, W P Zijlstra, D Widjaja, N Wolf, O Luminet, J Ellrich, Y Gidron
The vagus nerve is strategically located in the body, and has multiple homeostatic and health-promoting effects. Low vagal activity predicts onset and progression of diseases. These are the reasons to activate this nerve. This study examined the effects of transcutaneous vagus nerve stimulation (t-VNS) on a main index of vagal activity, namely heart rate variability (HRV). In Study 1, we compared short (10min) left versus right ear t-VNS versus sham (no stimulation) in a within-subjects experimental design...
November 30, 2016: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/28012885/vagus-nerve-stimulation-removal-or-replacement-involving-the-lead-and-the-electrode-surgical-technique-institutional-experience-and-outcome
#20
Charles Champeaux, Elisabeth Landré, Francine Chassoux, Michael Wilhelm Mann, Bertrand Devaux, Baris Turak
PURPOSE: To analyse the outcome of epileptic patients who had redo surgery involving the vagus nerve stimulation's lead. METHODS: We reviewed the clinical and surgical records of all patients who had a complete VNS removal or replacement or any redo surgical procedure involving the system lead at Sainte-Anne Hospital, Paris. RESULTS: Between the years 1999 and 2016, 41 redo surgical procedures involving the lead / the electrode were achieved, of which 23 complete VNS explantations, 12 complete system replacements, 5 lead changes only and one isolated lead removal...
December 21, 2016: World Neurosurgery
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