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Sedative load

Na Wang, Honglan Zhou, Xuesong Song, Jinguo Wang
BACKGROUND: Sufentanil is widely used for patient-controlled intravenous analgesia (PCIA). Oxycodone has a powerful analgesic effect and mild side effects. We conducted this study to compare the efficacy of oxycodone and sufentanil for PCIA on postoperative pain after laparoscopic radical gastrectomy. METHODOLOGY: A total of fifty patients scheduled for laparoscopic radical gastrectomy were equally randomized to receive postoperative pain treatment with either oxycodone (Group O) or sufentanil (Group S) for 48 h postoperatively...
September 2016: Anesthesia, Essays and Researches
Amar Parkash Kataria, Joginder Pal Attri, Ramita Kashyap, Leena Mahajan
BACKGROUND: The advent of laparoscopic surgeries has proved to be beneficial for both patient and surgeon although increased morbidity may result from hemodynamic changes associated with laryngoscopy, intubation, and pneumoperitoneum (PNP). AIM: The present study was prospective, randomized, double-blind conducted to evaluate the efficacy of dexmdetomidine and fentanyl in attenuation of pressor responses to laryngoscopy, intubation, and PNP in laparoscopic cholecystectomy (LC)...
September 2016: Anesthesia, Essays and Researches
Umut Kalyoncu, Hakan Emmungil, Ahmet Mesut Onat, Sedat Yılmaz, Timuçin Kaşifoglu, Servet Akar, Nevsun İnanç, Fatih Yıldız, Orhan Küçükşahin, Ömer Karadağ, Rıdvan Mercan, Cemal Bes, Veli Yazısız, Barış Yılmazer, Mustafa Özmen, Şükran Erten, Soner Şenel, Ayten Yazıcı, Koray Taşçılar, Melike Kalfa, Sedat Kiraz, Bünyamin Kısacık, Yavuz Pehlivan, Levent Kılıç, İsmail Şimşek, Ayşe Çefle, Nurullah Akkoç, Haner Direskeneli, Eren Erken, Murat Turgay, Mehmet Akif Öztürk, Mehmet Soy, Kenan Aksu, Ayhan Dinç, İhsan Ertenli
OBJECTIVE: The reactivation of hepatitis B virus (HBV) infection is a well-known event in hepatitis B surface antigen (HbsAg)-positive patients receiving immunosuppressive therapy. The objective of this study was to assess the antiviral practice and course of HBV infection in inflammatory arthritis. MATERIAL AND METHODS: Nineteen rheumatology centers participated in this retrospective study. HbsAg-positive patients who were taking disease-modifying antirheumatic drugs and who were being tested for HBV viral load at a minimum of two different time points were included...
December 2015: Eur J Rheumatol
Douk-Keun Yoon, Jong-Seouk Ban, Sang-Gon Lee, Ji-Hyang Lee, Eunju Kim, Jihyun An
BACKGROUND: Dexmedetomidine is a useful sedative agent for spinal anesthesia. However, it has been reported that dexmedetomidine decreases heart rate in a dose-dependent manner. In the current study, we compared the administration of a bolus dose of midazolam and bolus loading of dexmedetomidine over 10 min with the goal of identifying an additional method of sedation. METHODS: Ninety patients classified as American Society of Anesthesiologists physical status I-II who were undergoing spinal anesthesia were divided into two groups...
October 2016: Korean Journal of Anesthesiology
Giuseppe d'Orsi, Maria Grazia Pascarella, Tommaso Martino, Elena Carapelle, Francesca Pacillo, Maria Teresa Di Claudio, Daniela Mancini, Marina Trivisano, Carlo Avolio, Luigi M Specchio
PURPOSE: to evaluate the efficacy and safety of intravenous (IV) lacosamide (LCM) in the treatment of seizure clusters (SC) and status epilepticus (SE) in hospitalized adult patients. METHODS: we prospectively analyzed treatment response, seizure outcome, and adverse effects of IV LCM in 38 patients with seizure emergencies (15 with SC, 23 with SE) during a hospital stay. The loading dose of IV LCM was 200-400mg and the maintenance dose was 200-400mg daily. Response to IV LCM was evaluated within 20min, 4h and 24h of LCM infusion...
September 22, 2016: Seizure: the Journal of the British Epilepsy Association
Pui-San Loh, Mohd Azlan Ariffin, Vineya Rai, Lee-Lee Lai, Lucy Chan, Norlisah Ramli
STUDY OBJECTIVE: To determine the efficacy of sedation with dexmedetomidine compared to propofol for claustrophobic adults undergoing magnetic resonance imaging (MRI) in our institution. DESIGN: Randomized, prospective, double-blinded study. SETTING: University-based tertiary referral center. PATIENTS: Thirty claustrophobic adults with American Society of Anesthesiologists physical status I and II who were planned for MRI...
November 2016: Journal of Clinical Anesthesia
Mahtab Poorzamany Nejat Kermany, Mastaneh Dahi, Reyhaneh Yamini Sharif, Badiozaman Radpay
BACKGROUND: Dexmedetomidine is a potent and highly specific α2-adrenoreceptor agonist that induces sedative and analgesic effects over a short-term period. As a result of these benefits, dexmedetomidine may be a better alternative than other available drugs for keeping the patient's cognition state in an acceptable condition after outpatient ophthalmic surgeries. OBJECTIVES: This randomized study was conducted to compare the sedative effects of dexmedetomidine and remifentanil on the cognitive state of patients who have undergone cataract surgery...
June 2016: Anesthesiology and Pain Medicine
Tomoaki Yatabe, Takahiko Tamura, Koichi Yamashita, Masataka Yokoyama
STUDY OBJECTIVE: Some outpatient procedures are performed under sedation with dexmedetomidine, although the effect of dexmedetomidine on cognitive function remains unclear. This study investigated the effect of dexmedetomidine on cognitive function in healthy volunteers. DESIGN: Observation study in volunteers. SETTING: University-affiliated teaching hospital. PATIENTS: Six healthy volunteers. INTERVENTIONS: After infusion of a 6-μg/kg per hour loading dose of dexmedetomidine for 10 minutes, a maintenance infusion of 0...
September 2016: Journal of Clinical Anesthesia
Caroline Cole
CASE SUMMARY: A 6 yr old 45 kg child with severe Cushinoid features was admitted to PICU with probable hypertensive encephalopathy. She presented with increasing headaches, vomiting and seizures becoming unresponsive with a GCS of 3. She was profoundly hypertensive and her cortisol levels were significantly elevated (>2000 nmol/L). Rapid reduction in cortisol levels was required to stabilise her condition prior to surgery. Etomidate is the only readily available intravenous preparation which reliably suppresses adrenocortical function...
September 2016: Archives of Disease in Childhood
Abraham J Valkenburg, Elisa A M Calvier, Monique van Dijk, Elke H J Krekels, Brendan P O'Hare, William F Casey, Ron A A Mathôt, Catherijne A J Knibbe, Dick Tibboel, Cormac V Breatnach
OBJECTIVE: To compare the pharmacodynamics and pharmacokinetics of IV morphine after cardiac surgery in two groups of children-those with and without Down syndrome. DESIGN: Prospective, single-center observational trial. SETTING: PICU in a university-affiliated pediatric teaching hospital. PATIENTS: Twenty-one children with Down syndrome and 17 without, 3-36 months old, scheduled for cardiac surgery with cardiopulmonary bypass...
October 2016: Pediatric Critical Care Medicine
Ting Xu, Min Li, Cheng Ni, Xiang-Yang Guo
BACKGROUND: The purpose of this study was to compare the efficacy and safety of dexmedetomidine versus remifentanil for sedation during awake intubation using a Shikani optical stylet (SOS). METHODS: Sixty-eight patients with cervical trauma or severe cervical spondylosis undergoing cervical spinal surgery were enrolled in this prospective study. They were randomly assigned to receive dexmedetomidine (Group D) or remifentanil (Group R). In Group D, the patients received an intravenous loading dose of dexmedetomidine 1 μg · kg(-1) over 10 min followed by a continuous infusion of 0...
2016: BMC Anesthesiology
X-N Zhao, J-H Ran, A R Bajracharya, M-Y Ma
OBJECTIVE: Dexmedetomidine, a highly selective α2-adrenergic receptor agonist with sedative and analgesic properties, is used as an anesthetic adjunct. We determined the effects of different dexmedetomidine doses on the median effective concentration (EC50) of propofol and bispectral index (BIS) values during anesthesia induction. PATIENTS AND METHODS: This randomized, prospective, case-control clinical trial involved 120 patients (56 women; physical status, American Society of Anesthesiologists grades I or II) scheduled to undergo surgery requiring general anesthesia from July 15th, 2014 to June 15th, 2015...
July 2016: European Review for Medical and Pharmacological Sciences
Jacobo Limeres Posse, Julian López Jiménez, José C Ruiz Villandiego, Antonio Cutando Soriano, Javier Fernández Feijoo, Maialen Linazasoro Elorza, Márcio Diniz Freitas, Pedro Diz Dios
STATEMENT OF PROBLEM: The need for tooth replacement in individuals with Down syndrome (DS) is explained by the high prevalence of dental agenesis and by the premature loss of teeth through severe periodontal disease. Dental implants may be the dental procedure of choice in some of these patients. PURPOSE: The purpose of this clinical study was to analyze dental implant survival in a series of patients with DS. MATERIAL AND METHODS: This was a multicenter, retrospective, observational study...
July 23, 2016: Journal of Prosthetic Dentistry
Tanveer Singh Kundra, P S Nagaraja, Naveen G Singh, Manasa Dhananjaya, N Sathish, N Manjunatha
INTRODUCTION: Dexmedetomidine is an alpha-2 agonist used for conscious sedation. It has also been shown to have a myocardial protective effect in off-pump coronary artery bypass patients. The aim of the study was to assess the effect of dexmedetomidine for myocardial protection in percutaneous coronary interventional patients. METHODOLOGY: A total of 60 patients (group dexmedetomidine, n = 30 and group normal saline, n = 30) were enrolled in the study. Dexmedetomidine infusion (1 mcg/kg) over 15 min was given as a loading dose after coronary angiography in group dexmedetomidine (D) while normal saline was given in the control group (C) and later maintenance infusion was started at 0...
July 2016: Annals of Cardiac Anaesthesia
Lei Fan, Ji Zhang, Zhifeng Lv, Huafeng Guo, Yan Zhao
To investigate the effect and safety of dexmedetomidine applied for patient-controlled sedation under combined spinal anesthesia. 150 cases who would be implemented lower limbs operations were randomly divided into patient-controlled sedation group (Group PCS) and control group (Group C) and 75 cases for each group. The ages of patients were between 18 and 65 years old and patients were with American Society of Anesthesiologists (ASA) or level. After being implemented combined spinal anesthesia, patients of Group PCS were undergone patient-controlled sedation by using dexmedetomidine (4μg/mL) with 2mL of load quantity, 1...
May 2016: Pakistan Journal of Pharmaceutical Sciences
Laurence Dangers, Louis Laviolette, Bény Charbit, Thomas Similowski, Capucine Morélot-Panzini
BACKGROUND: Dyspnoea is a distressing and debilitating symptom with a major impact on quality of life. Alleviation of dyspnoea therefore constitutes a major clinical challenge. When causative physiological disorders cannot be corrected ("persistent dyspnoea"), nonspecific treatment must be considered. Morphine alleviates dyspnoea but has numerous side-effects including ventilatory depression, which justifies looking for alternatives. Certain forms of dyspnoea involve C-fibres, and can be attenuated by C-fibres blockade...
August 2016: Pulmonary Pharmacology & Therapeutics
Kelly Cristina de Carvalho, Carina Gonçalves Pedroso Uchida, Mirian Salvadori Bittar Guaranha, Laura Maria F F Guilhoto, Peter Wolf, Elza Márcia Targas Yacubian
PURPOSE: Juvenile myoclonic epilepsy (JME) is a heterogeneous syndrome in which seizures can be precipitated not only by non-specific factors, such as sleep deprivation and stress, but also by specific stimuli, such as photic stimuli, eye-closure, praxis, and language. The presence of these reflex traits may indicate the hyperexcitability of different cortical areas, which may be reflected in patients' neuropsychological deficit profile. The objective of our study is to investigate the possible relations between JME endophenotypes and patients' cognitive performance...
August 2016: Seizure: the Journal of the British Epilepsy Association
Bhawana Sharma, Sunny Rupal, Adarsh Chandra Swami, Sneh Lata
BACKGROUND AND AIMS: Total knee replacement (TKR) patients experience considerable post-operative pain. We evaluated whether addition of perineural dexmedetomidine to ropivacaine 0.2% in the femoral nerve block would enhance post-operative analgesia in patients undergoing unilateral TKR under spinal anaesthesia. METHODS: Fifty patients were allocated randomly to two groups of 25 each. Group D received ropivacaine (0.2%) with dexmedetomidine (1.5 μg/kg), and Group C received ropivacaine (0...
June 2016: Indian Journal of Anaesthesia
Mohamed Khalil, Ahmed Al-Agaty, Osama Asaad, Mohsen Mahmoud, Amr S Omar, Ahmed Abdelrazik, Mohamed Mostafa
OBJECTIVE: The type of sedative drugs could play a major role in providing hemodynamic stability which is crucial during transcatheter aortic valve implantation (TAVI) procedure. The aim of this study is to compare propofol with dexmedetomidine for conscious sedation during TAVI. DESIGN: A prospective randomized pilot study. PATIENTS: Fifty patients with a mean age of 74years, American Society of Anesthesiologists 3-4, complaining from severe aortic stenosis were enrolled in this study to undergo TAVI...
August 2016: Journal of Clinical Anesthesia
Sukhminder Jit Singh Bajwa, Jasleen Kaur, Ashish Kulshrestha, Rudrashish Haldar, Rakesh Sethi, Amarjit Singh
BACKGROUND AND AIM: Induced hypotension limits intra-operative blood loss to provide better visibility of the surgical field and diminishes the incidence of major complications during functional endoscopic sinus surgery (FESS). We aimed at comparing nitroglycerine, esmolol and dexmedetomidine for inducing controlled hypotension in patients undergoing FESS. MATERIAL AND METHODS: One hundred and fifty American Society of Anesthesiologists physical status I or II adult patients undergoing FESS under general anesthesia were randomly allocated to three groups of 50 patients each...
April 2016: Journal of Anaesthesiology, Clinical Pharmacology
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