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https://www.readbyqxmd.com/read/28222762/the-hippo-component-yap-localizes-in-the-nucleus-of-human-papilloma-virus-positive-oropharyngeal-squamous-cell-carcinoma
#1
Faisal Alzahrani, Leanne Clattenburg, Shanmugam Muruganandan, Martin Bullock, Kaitlyn MacIsaac, Michael Wigerius, Blair A Williams, M Elise R Graham, Matthew H Rigby, Jonathan R B Trites, S Mark Taylor, Christopher J Sinal, James P Fawcett, Robert D Hart
BACKGROUND: HPV infection causes cervical cancer, mediated in part by the degradation of Scribble via the HPV E6 oncoprotein. Recently, Scribble has been shown to be an important regulator of the Hippo signaling cascade. Deregulation of the Hippo pathway induces an abnormal cellular transformation, epithelial to mesenchymal transition, which promotes oncogenic progression. Given the recent rise in oropharyngeal HPV squamous cell carcinoma we sought to determine if Hippo signaling components are implicated in oropharyngeal squamous cell carcinoma...
February 22, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28214204/detection-of-occult-endocervical-glandular-dysplasia-in-cervical-conization-specimens-for-squamous-lesions
#2
F Sopracordevole, N Clemente, L Alessandrini, J Di Giuseppe, F Cigolot, M Buttignol, A Ciavattini, V Canzonieri
The aim of this work was to evaluate the incidence of occult cervical glandular intraepithelial neoplasia (CGIN) and adenocarcinoma of the cervix (AC) in women treated with CO2-laser conization for cervical intraepithelial neoplasia (CIN) or squamocellular cervical cancer (SCC). The medical records of all women with a histological diagnosis of squamous lesions of the uterine cervix (persistent CIN1, CIN2, CIN3 and SCC) who were subsequently treated with CO2-laser conization at our institution, during the period from January 1991 to December 2014, were analyzed in a retrospective case series...
January 12, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28213875/vehicle-type-affects-filling-of-fractional-laser-ablated-channels-imaged-by-optical-coherence-tomography
#3
Uffe Høgh Olesen, Mette Mogensen, Merete Haedersdal
Ablative fractional laser (AFXL) is an emerging method that enhances topical drug delivery. Penetrating the skin in microscopic, vertical channels, termed microscopic treatment zones (MTZs), the fractional technique circumvents the skin barrier and allows increased uptake of topically applied drugs. This study aims to elucidate the impact of vehicle type on the filling of MTZs from application of liquid, gel, and cream vehicles. Ex vivo pig skin was exposed to 10,600 nm fractional CO2 laser at 5% density, 120 μm beam diameter, and fluences of 40 and 80 mJ/microbeam (mJ/mb)...
February 17, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28208177/feasibility-and-associated-limitations-of-office-based-laryngeal-surgery-using-carbon-dioxide-lasers
#4
Hao-Chun Hu, Shu-Yi Lin, Yi-Ting Hung, Shyue-Yih Chang
Importance: There are few reports evaluating awake, office-based carbon dioxide (CO2) laser surgery for laryngeal lesions. To date, this study was the largest reported case series of office-based laryngeal surgery by fiber delivery CO2 laser. Office-based laryngeal surgical procedures have become increasingly popular. Technical problems and treatment outcomes associated with the use of a CO2 laser for office-based laryngeal surgery have yet to be fully addressed. Objectives: To discuss a single institution's clinical experience with office-based CO2 laser laryngeal surgery and the feasibility and limitations associated with this procedure...
February 16, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28207466/the-subunit-principle-in-scar-face-revision
#5
Ahmed Elshahat, Riham Lashin
Facial scaring is considered one of the most difficult cosmetic problems for any plastic surgeon to solve. The condition is more difficult if the direction of the scar is not parallel to relaxed skin tension lines. Attempts to manage this difficult situation included revisions using geometric designs, Z plasties or W plasties to camouflage the straight line visible scaring. The use of long-lasting resorbable sutures was tried too. Recently, the use of botulinum toxin during revision improved the results. Fractional CO2 lasers, microfat grafts, and platelet-rich plasma were added to the armamentarium...
February 15, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28198069/ultrapulse-carbon-dioxide-laser-treatment-for-bilateral-facial-nevus-comedonicus-a-case-report
#6
Caiyong Zhu, Aijuan Sun
Nevus comedonicus (NC), a rare skin ailment with an aggregation of dilated follicular orifices filled with keratinous material, is difficult to treat. Several drugs have been assessed for the treatment of NC, but with limited success. Surgery requires much experience and the recurrence rate is high. Various types of laser have been tried, with promising outcomes. A 54-year-old male patient with bilateral facial NC was admitted on July 8, 2014. A coin-sized area was first treated successfully with ultrapulse CO2 laser...
February 15, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/28195854/lateral-inhibition-during-nociceptive-processing
#7
Alexandre S Quevedo, Carsten Dahl Mørch, Ole K Andersen, Robert C Coghill
Spatial summation of pain is the increase of perceived intensity that occurs as the stimulated area increases. Spatial summation of pain is sub-additive in that increasing the stimulus area produces a disproportionately small increase in the perceived intensity of pain. A possible explanation for sub-additive summation may be that convergent excitatory information is modulated by lateral inhibition. To test the hypothesis that lateral inhibition may limit spatial summation of pain, we delivered different patterns of noxious thermal stimuli to the abdomens of 15 subjects using a computer-controlled CO2-laser...
February 11, 2017: Pain
https://www.readbyqxmd.com/read/28194943/nylon-graphene-composite-nonwovens-as-monolithic-conductive-or-capacitive-fabrics
#8
Qin Pan, Eunkyoung Shim, Behnam Pourdeyhimi, Wei Gao
Here we describe a nylon-graphene nonwoven (NGN) composite, prepared via melt-blowing of nylon-6 into nonwoven fabrics and infiltrate those with graphene oxide (GO) in aqueous dispersions, which were further chemically reduced into graphene to offer electrical conductivity. The correlation between the conductivity and the graphene loading is described by the percolation scaling law σ = (p - pc)(t), with an exponent t of 1.2 and a critical concentration pc of 0.005 wt %, the lowest among all the nylon composites reported...
February 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28177327/functional-outcomes-of-supraglottic-squamous-cell-carcinoma-treated-by-transoral-laser-microsurgery-compared-with-horizontal-supraglottic-laryngectomy-in-patients-younger-and-older-than-65-years
#9
C M Chiesa Estomba, F A Betances Reinoso, A I Lorenzo Lorenzo, J L Fariña Conde, J Araujo Nores, C Santidrian Hidalgo
The treatment of supraglottic carcinoma remains a controversial issue. Five accepted surgical and non-surgical oncological treatments have been currently established: standard horizontal supraglottic laryngectomy (HSL), supraglottic CO2 laser microsurgery (TLM), transoral robotic surgery, radiotherapy alone and radiotherapy in combination with chemotherapy. Some studies have shown that complications of head and neck surgeries increase significantly in patients over 65 years compared to younger patients. We designed a retrospective analysis to assess the rate of complications and functional outcomes of patients treated by TLM and HSL in cases of T1-T3 supraglottic squamous cell carcinomas (SCC) in a tertiary University Hospital...
December 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/28169913/use-of-a-novel-fractional-co2-laser-for-the-treatment-of-genitourinary-syndrome-of-menopause-1-year-outcomes
#10
Eric R Sokol, Mickey M Karram
OBJECTIVES: To assess safety and efficacy of a fractional CO2 laser therapy for the treatment of genitourinary syndrome of menopause (GSM) with follow-up to 1 year posttreatment. METHODS: Women presenting with GSM and meeting inclusion criterion were enrolled. Visual Analog Scales were used to grade vaginal pain, burning, itching, dryness, dyspareunia, and dysuria. Dilators were used to rate vaginal elasticity at baseline and at each follow-up visit. Before each treatment and at follow-up, Vaginal Health Index scoring and Female Sexual Function Index questionnaires were completed...
February 6, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28168615/spiral-antenna-coupled-microbridge-structures-for-thz-application
#11
Jun Gou, Tian Zhang, Jun Wang, Yadong Jiang
Bolometer sensor is a good candidate for THz imaging due to its compact system, low cost, and wideband operation. Based on infrared microbolometer structures, two kinds of antenna-coupled microbridge structures are proposed with different spiral antennas: spiral antenna on support layer and spiral antenna with extended legs. Aiming at applications in detection and imaging, simulations are carried out mainly for optimized absorption at 2.52 THz, which is the radiation frequency of far-infrared CO2 lasers. The effects of rotation angle, line width, and spacing of the spiral antenna on THz wave absorption of microbridge structures are discussed...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28166434/a-systematic-review-of-comparative-studies-of-co2anderbium-yag-lasers-in-resurfacing-facial-rhytides-wrinkles
#12
Kee-Hsin Chen, Ka-Wai Tam, I-Fan Chen, Shihping Kevin Huang, Pei-Chuan Tzeng, Hsian-Jenn Wang, Chiehfeng Cliff Chen
BACKGROUND: Laser resurfacing is used to minimize wrinkles, solar scars, and sequelae of acne. OBJECTIVE: Purpose of the systemic review was to compare resurfacing outcomes of CO2 laser and erbium: yttrium-aluminum-garnet (erb:YAG) laser therapies. METHODS AND MATERIALS: Medline, Cochrane, EMBASE, Google Scholar databases were searched until April 9, 2015 using the following terms: laser, carbon dioxide/CO2, facial wrinkles, rhytides, erbium-doped yttrium aluminum garnet/erbium:YAG/Er:YAG...
February 6, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28157763/effect-of-procedural-related-variables-on-melanocyte-keratinocyte-suspension-transplantation-in-nonsegmental-stable-vitiligo-a-clinical-and-immunocytochemical-study
#13
Bakr Mohamed El-Zawahry, Samia Esmat, Dalia Bassiouny, Naglaa Sameh Zaki, Rehab Sobhi, Marwah A Saleh, Dalia Abdel-Halim, Rehab Hegazy, Heba Gawdat, Nesrin Samir, Marwa El-Hawary, Zeinab El Maadawi, Heba Gouda, Mervat Khorshied
BACKGROUND: Melanocyte-keratinocyte suspension (M-K susp) is gaining popularity for vitiligo treatment. Few studies have addressed procedure-related variables. OBJECTIVE: To assess the effect of different M-K susp procedure-related variables on the clinical outcome in stable vitiligo. METHODS: This prospective multicenter comparative study included 40 cases with nonsegmental stable vitiligo. Donor site was either a skin graft in noncultured epidermal cell suspension (NCECS) or hair follicle units in outer root sheath hair follicle suspension (ORSHFS)...
February 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28157423/effect-of-nd-yag-and-co2-laser-irradiation-on-prevention-of-enamel-demineralization-in-orthodontics-in-vitro-study
#14
Renato Siva Paulos, Priscila Yumi Seino, Karen Akemi Fukushima, Marcia Martins Marques, Fernanda Campos Sousa de Almeida, Karen Muller Ramalho, Patricia Moreira de Freitas, Aldo Brugnera, Maria Stella Moreira
OBJECTIVE: The aim of this study was to investigate Nd:YAG and CO2 laser effects in the prevention of demineralization in deeper layers of enamel via successive acid challenge cycles. BACKGROUND DATA: Lasers are promising in the prevention of enamel demineralization around the orthodontic brackets; however, there are very few studies that evaluate if the effects of treatment could be extended after successive acid challenge cycles due to permanent enamel structural alterations...
January 18, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28153526/two-stage-co2-laser-assisted-bilateral-cordectomy-for-ct1b-glottic-carcinoma
#15
Andy Bertolin, Marco Lionello, Gianni Salis, Giuseppe Rizzotto, Marco Lucioni
PURPOSE: The aim of the present paper was to investigate the oncological safety of two-stage bilateral cordectomy for the treatment of cT1b glottic SCC, and to compare its oncological outcome and synechia development rate with those of single-stage procedures. MATERIALS AND METHODS: A retrospective cohort study was performed at the Otolaryngology Unit of Vittorio Veneto Laryngeal Cancer Center (Italy). The prognostic significance of clinical, pathological and surgical factors was also investigated, in terms of recurrence rate and disease-free survival, in a univariate statistical setting...
January 18, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28145742/quartz-enhanced-photoacoustic-spectroscopy-qepas-detection-of-the-%C3%AE-7-band-of-ethylene-at-low-pressure-with-co2-interference-analysis
#16
Zhen Wang, Jian Geng, Wei Ren
Ethylene (C2H4) was detected using quartz-enhanced photoacoustic spectroscopy (QEPAS) at 10.5 µm with a continuous wave, distributed-feedback quantum cascade laser as the light source. The QEPAS sensor was operated at low pressures (≤200 torr) to eliminate the cross-talk spectral interference between C2H4 and CO2, a major interfering species in practical applications. The sensor was calibrated to show a good linear response to C2H4 concentration and the Allan deviation analysis demonstrated a minimum detection limit of 8 ppb at an integration time of 90 s...
January 1, 2017: Applied Spectroscopy
https://www.readbyqxmd.com/read/28145558/influence-of-a-pulsed-co2-laser-operating-at-9-4%C3%A2-%C3%A2-%C3%AE-m-on-the-surface-morphology-reflectivity-and-acid-resistance-of-dental-enamel-below-the-threshold-for-melting
#17
Jin Wan Kim, Raymond Lee, Kenneth H Chan, Jamison M Jew, Daniel Fried
No abstract text is available yet for this article.
February 1, 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28139023/investigation-of-the-predictive-validity-of-laser-eps-on-normal-uvb-and-capsaicin-irritated-skin-with-4-analgesic-compounds-in-healthy-volunteers
#18
Klaus Schaffler, Laurent B Nicolas, Andreas Borta, Tobias Brand, Peter Reitmeir, Robert Roebling, Joachim Scholpp
AIMS: To assess predictivity of laser-(radiant-heat)-evoked-potentials (LEPs) from vertex-EEG, as algesimetric procedure, testing anti-nociceptive/anti-hyperalgesic effects of single oral doses of 4 marketed analgesics (different compound classes) vs. placebo with healthy volunteers in 3 skin types. METHODS: This was a randomized, placebo-controlled, single-blind, 5-way-crossover trial. Twenty-five healthy female/male Caucasians were included (receiving celecoxib 200 mg, pregabalin 150 mg, duloxetine 60 mg, lacosamide 100 mg, placebo) in a Williams design with CO2 -laser-induced painful stimuli on normal, UVB-inflamed and capsaicin-irritated skin...
January 31, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28133868/use-of-topical-sirolimus-in-the-management-of-multiple-familial-trichoepitheliomas
#19
Joanna H Tu, Joyce M C Teng
The management of trichoepitheliomas is challenging, especially in children. This challenge is exemplified in patients with multiple trichoepitheliomas who present with progression of lesion count and size despite treatment with current strategies, including CO2 laser and surgery. We present the novel use of topical 1% sirolimus cream in two siblings with multiple facial trichoepitheliomas; one was treated with a combination of CO2 laser ablation and topical sirolimus, and the other was treated with topical sirolimus alone...
January 30, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/28132137/influence-of-irradiation-by-a-novel-co2-9-3-%C3%AE-m-short-pulsed-laser-on-sealant-bond-strength
#20
P Rechmann, K Sherathiya, R Kinsel, R Vaderhobli, B M T Rechmann
The objective of this in vitro study was to evaluate whether irradiation of enamel with a novel CO2 9.3-μm short-pulsed laser using energies that enhance caries resistance influences the shear bond strength of composite resin sealants to the irradiated enamel. Seventy bovine and 240 human enamel samples were irradiated with a 9.3-μm carbon dioxide laser (Solea, Convergent Dental, Inc., Natick, MA) with four different laser energies known to enhance caries resistance or ablate enamel (pulse duration from 3 μs at 1...
January 29, 2017: Lasers in Medical Science
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