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https://www.readbyqxmd.com/read/27923588/autophagy-and-akt-creb-signalling-play-an-important-role-in-the-neuroprotective-effect-of-nimodipine-in-a-rat-model-of-vascular-dementia
#1
Ming Hu, Zhijuan Liu, Peiyuan Lv, Hebo Wang, Yifei Zhu, Qianqian Qi, Jing Xu
The Akt/CREB signalling pathway is involved in neuronal survival and protection. Autophagy is also likely to be involved in survival mechanisms. Nimodipine is an L-type calcium channel antagonist that reduces excessive calcium influx during pathological conditions (contributing to its neuroprotective properties). However, the potential role of nimodipine in autophagic and Akt/CREB signalling is not well understood. In addition, little is known about the relationship between autophagic and Akt/CREB signalling...
December 3, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27917283/protective-effects-of-nimodipine-and-lithium-against-aluminum-induced-cell-death-and-oxidative-stress-in-pc12-cells
#2
Jamileh Saberzadeh, Mehdi Omrani, Mohammad Ali Takhshid
OBJECTIVES: The role of aluminum (Al) in the pathogenesis of neurodegenerative diseases has been implicated in several studies. However, the exact mechanisms of cytotoxic effects of Al have not been elucidated yet. The aim of this study was to investigate the effect of L-type calcium channel antagonist, nimodipine (NM), and lithium chloride (LiCl) on Al-induced toxicity in PC12 cells. MATERIALS AND METHODS: PC12 cells were treated with Al-maltolate (Almal) in the presence and absence of different concentrations of NM (50-150 μm) and/or LiCl (0...
November 2016: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/27900416/-intensive-care-treatment-after-aneurysmal-subarachnoid-hemorrhage
#3
U Jaschinski
Aneurysmal subarachnoid hemorrhage (SAH) is a devastating disease and nearly one third of patients die in the acute phase. Due to the bleeding event, a hyperactive sympathetic nervous system and an uncontrolled inflammatory response have a profound local and systemic impact on other organ functions. Neuroendocrinological disorders and cardiopulmonary morbidity are dominant. Despite a decrease in hospital mortality for high volume centers, a high proportion of survivors suffer from neurological deficits. Knowledge of the pathophysiology of vasospasms in the later stages of the disease has increased...
November 29, 2016: Der Anaesthesist
https://www.readbyqxmd.com/read/27894149/2-3-5-4-tetrahydroxystilbene-2-o-%C3%AE-d-glucoside-attenuates-ischemia-reperfusion-induced-brain-injury-in-rats-by-promoting-angiogenesis
#4
Ying Mu, Zhaohui Xu, Xuanxuan Zhou, Huinan Zhang, Qian Yang, Yunlong Zhang, Yanhua Xie, Juan Kang, Feng Li, Siwang Wang
Cerebral ischemia can cause brain infarcts, which are difficult to recover due to poor angiogenesis. 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside is a natural polyphenol, has antioxidant and anti-inflammatory activity, and can protect from ischemic neuronal injury. However, little is known about the effect of 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside on brain microcirculation after stroke. This study aimed at investigating the influence of 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside on brain lesions and angiogenesis after stroke...
November 28, 2016: Planta Medica
https://www.readbyqxmd.com/read/27889432/decrease-of-high-voltage-ca-2-currents-in-the-dentate-gyrus-granule-cells-by-entorhinal-amyloidopathy-is-reversed-by-calcium-channel-blockade
#5
Hamid Gholami Pourbadie, Nima Naderi, Hadi Mirzapour Delavar, Mahshid Hosseinzadeh, Nasrin Mehranfard, Fariba Khodagholi, Mahyar Janahmadi, Fereshteh Motamedi
In the Alzheimer's disease (AD), entorhinal-hippocampal circuit is one of the earliest affected networks. There are some evidences indicating abnormal neuronal excitability and impaired synaptic plasticity in the dentate gyrus (DG) of AD animal model. However, the underlying mechanism leading to DG dysfunction particularly in the early phase of AD is not known. Since calcium dyshomeostasis has a critical role in the etiology of AD, it is possible that this phenomenon precedes electrophysiological alteration in the DG...
November 24, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27834149/development-and-evaluation-of-high-bioavailable-sustained-release-nimodipine-tablets-prepared-with-monolithic-osmotic-pump-technology
#6
Hua Kong, Fanglin Yu, Yan Liu, Yangyang, Mingyuan Li, Xiaohui Cheng, Xiaoqin Hu, Xuemei Tang, Zhiping Li, Xingguo Mei
BACKGROUND: Frequent administration caused by short half-life and low bioavailability due to poor solubility and low dissolution rate limit the further application of poorly water-soluble nimodipine although several new indications have been developed. To overcome these shortcomings, sophisticated technologies had to be used since the dose of nimodipine is not too low and the addition of solubilizers couldn't resolve the problem of poor release. OBJECTIVE: The purpose of this study was to obtain sustained and complete release of nimodipine with a simple and easily industrialized technology...
November 9, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/27812447/continuous-intra-arterial-nimodipine-infusion-in-refractory-symptomatic-vasospasm-after-subarachnoid-hemorrhage
#7
Raimund Helbok, Alexandra Zangerle, Andreas Chemelli, Ronny Beer, Thomas Benke, Rainer Ehling, Marlene Fischer, Martin Sojer, Bettina Pfausler, Claudius Thome, Erich Schmutzhard
INTRODUCTION: Vasospasm still is a major cause of morbidity after aneurysmal subarachnoid hemorrhage. The purpose of this report is to describe the successful management of severe refractory vasospasm with continuous intra-arterial nimodipine (IAN) treatment. CASE DESCRIPTION: A 72-year old right handed woman was admitted with non-traumatic SAH WFNS grade 1. Cerebral computed tomography demonstrated thick blood filling of the basal cisterns, and intraventricular hemorrhage...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27737684/management-of-delayed-cerebral-ischemia-after-subarachnoid-hemorrhage
#8
REVIEW
Charles L Francoeur, Stephan A Mayer
For patients who survive the initial bleeding event of a ruptured brain aneurysm, delayed cerebral ischemia (DCI) is one of the most important causes of mortality and poor neurological outcome. New insights in the last decade have led to an important paradigm shift in the understanding of DCI pathogenesis. Large-vessel cerebral vasospasm has been challenged as the sole causal mechanism; new hypotheses now focus on the early brain injury, microcirculatory dysfunction, impaired autoregulation, and spreading depolarization...
October 14, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27731633/ith14001-a-cgp37157-nimodipine-hybrid-designed-to-regulate-calcium-homeostasis-and-oxidative-stress-exerts-neuroprotection-in-cerebral-ischemia
#9
Izaskun Buendia, Giammarco Tenti, Patrycja Michalska, Iago Méndez-López, Enrique Luengo, Michele Satriani, Juan Fernando Padin Nogueira, Manuela G López, María Teresa Ramos, Antonio G García, J Carlos Menéndez, Rafael León
During brain ischemia, oxygen and glucose deprivation induces calcium overload, extensive oxidative stress, neuroinflammation and, finally, massive neuronal loss. In the search of a neuroprotective compound to mitigate this neuronal loss, we have designed and synthesized a new multitarget hybrid (ITH14001) directed at the reduction of calcium overload by acting on two regulators of calcium homeostasis; the mitochondrial Na+/Ca2+ exchanger (mNCX) and L-type voltage dependent calcium channels (VDCCs). This compound is a hybrid of CGP37157 (mNCX inhibitor) and nimodipine (L-type VDCCs blocker), and its pharmacological evaluation revealed a moderate ability to selectively inhibit both targets...
October 12, 2016: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/27721780/the-need-for-a-rational-approach-to-vasoconstrictive-syndromes-transcranial-doppler-and-calcium-channel-blockade-in-reversible-cerebral-vasoconstriction-syndrome
#10
Elisabeth B Marsh, Wendy C Ziai, Rafael H Llinas
INTRODUCTION: Reversible cerebral vasoconstriction syndrome (RCVS) typically affects young patients and left untreated can result in hemorrhage or ischemic stroke. Though the disorder has been well characterized in the literature, the most appropriate way to diagnose, treat, and evaluate therapeutic response remains unclear. In previous studies, transcranial Doppler ultrasound (TCD) has shown elevated velocities indicative of vasospasm. This imaging modality is noninvasive and inexpensive; an attractive option for diagnosis and therapeutic monitoring if it is sensitive enough to detect changes in the acute setting given that RCVS often affects the distal vessels early in the course of disease...
May 2016: Case Reports in Neurology
https://www.readbyqxmd.com/read/27709016/effect-of-age-on-the-pharmacokinetics-of-polymorphic-nimodipine-in-rats-after-oral-administration
#11
Wenli Liu, Xiaona Wang, Ruilian Chen, Kaixuan Zhang, Yao Li, Yi Li, Duanyun Si, Junbo Gong, Dianshu Yin, Yongli Wang, Zhenping Wei, Mingshi Yang
The previous investigation has proved that their existed pharmacokinetic difference between the different crystal forms of the polymorphic drugs after oral administration. However, no systemic investigations have been made on the change of this pharmacokinetic difference, resulted either from the physiological or from the pathological factors. In this paper, we used polymorphic nimodipine (Nim) as a model drug and investigated the effect of age difference (2- and 9-month old) on the pharmacokinetics after oral delivery in rats...
September 2016: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/27664068/cxcl12-induced-neurotoxicity-critically-depends-on-nmda-receptor-gated-and-l-type-ca-2-channels-upstream-of-p38-mapk
#12
Ana B Sanchez, Kathryn E Medders, Ricky Maung, Paloma Sánchez-Pavón, Daniel Ojeda-Juárez, Marcus Kaul
BACKGROUND: The chemokine receptor CXCR4 (CD184) and its natural ligand CXCL12 contribute to many physiological processes, including decisions about cell death and survival in the central nervous system. In addition, CXCR4 is a co-receptor for human immunodeficiency virus (HIV)-1 and mediates the neurotoxicity of the viral envelope protein gp120. However, we previously observed that CXCL12 also causes toxicity in cerebrocortical neurons but the cellular mechanism remained incompletely defined...
2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27637674/spontaneous-subarachnoid-haemorrhage
#13
R Loch Macdonald, Tom A Schweizer
Subarachnoid haemorrhage is an uncommon and severe subtype of stroke affecting patients at a mean age of 55 years, leading to loss of many years of productive life. The rupture of an intracranial aneurysm is the underlining cause in 85% of cases. Survival from aneurysmal subarachnoid haemorrhage has increased by 17% in the past few decades, probably because of better diagnosis, early aneurysm repair, prescription of nimodipine, and advanced intensive care support. Nevertheless, survivors commonly have cognitive impairments, which in turn affect patients' daily functionality, working capacity, and quality of life...
September 13, 2016: Lancet
https://www.readbyqxmd.com/read/27624481/guhong-injection-protects-against-focal-cerebral-ischemia-reperfusion-injury-via-anti-inflammatory-effects-in-rats
#14
Jinchao Ai, Haitong Wan, Mingchun Shu, Huifen Zhou, Tao Zhao, Wei Fu, Yu He
Guhong injection (GHI), composed of aceglutamide and safflower aqueous extract, has been used clinically for the treatment of cerebrovascular diseases such as cerebral embolism, hemorrhage and mental deterioration. In this paper, we reported the results of the first study on the anti-inflammatory effects of GHI in murine focal cerebral ischemia-reperfusion (I/R) injury. Adult male SD rats were randomly divided into six groups: Sham group, I/R group, GHI-L group (2.5 mL/kg), GHI-M group (5 mL/kg), GHI-H group (10 mL/kg) and Nimodipine group...
September 13, 2016: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/27623621/efficacy-and-safety-assessment-of-acupuncture-and-nimodipine-to-treat-mild-cognitive-impairment-after-cerebral-infarction-a-randomized-controlled-trial
#15
Shuhua Wang, Hongling Yang, Jie Zhang, Bin Zhang, Tao Liu, Lu Gan, Jiangang Zheng
BACKGROUND: Cerebral infarction frequently leads to mild cognitive impairment (MCI). Prompt management of MCI can prevent vascular dementia and improve patient outcome. This single center randomized controlled trial aims to investigate the efficacy and safety of acupuncture and nimodipine to treat post-cerebral infarction MCI. METHODS: A total of 126 Chinese patients with post-cerebral infarction MCI recruited from the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine between April 2013 and June 2014 were randomized at 1:1: 1 ratio into nimodipine alone (30 mg/time and 3 times daily), acupuncture alone (30 min/time, 6 times/week), and nimodipine + acupuncture groups...
2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27593840/comparison-of-the-effects-and-mechanism-of-the-curcumin-with-different-acting-drugs-in-experimental-vasospasm-after-subarachnoid-hemorrhage
#16
Hasan Emre Aydin, Nuriye Ezgi Bektur, Zuhtu Ozbek, Setenay Oner, Cengiz Baycu, Fatma Sultan Kiliç
AIM: Cerebral vasospasm following subarachnoid hemorrhage (SAH) is the most important complication which effects mortality and morbidity of patients with intracranial aneurysm although effective treatment. Today, the mechanisms of vasospasm is not understood in spite of experimetal and clinical researches. The aim of our study to investigate the effect of curcumin which used in medical treatment of some illness and known antioxidant drug on vasospasm following SAH. MATERIAL AND METHODS: In this study, 200-250 gr weight and 64 rats were divided into 7 groups...
May 25, 2016: Turkish Neurosurgery
https://www.readbyqxmd.com/read/27585466/panax-notoginseng-saponins-administration-modulates-pro-anti-inflammatory-factor-expression-and-improves-neurologic-outcome-following-permanent-mcao-in-rats
#17
Xiaowei Shi, Wenjing Yu, Lixing Liu, Wei Liu, Xiaomeng Zhang, Tiantian Yang, Limin Chai, Lixia Lou, Yonghong Gao, Lingqun Zhu
Ischemic stroke, particularly permanent occlusion, accounts for the overwhelming majority of all strokes. In addition to the occlusion of arteries, the inflammatory response plays a pivotal role in the severity of the cerebral injury and its clinical prognosis. Here, panax notoginseng saponins (PNS) extracted from a traditional Chinese herbal medicine was administered following permanent middle cerebral artery occlusion (MCAO) in rats to explore the neuroprotective mechanisms against ischemic injury. The results showed that MCAO surgery was successful in producing an infarct and that PNS and nimodipine could ameliorate the neurological deficits...
September 2, 2016: Metabolic Brain Disease
https://www.readbyqxmd.com/read/27532878/protective-effects-of-transient-receptor-potential-canonical-channels-on-oxygen-glucose-deprivation-induced-cell-injury-in-neurons-and-pc12-cells
#18
Yan Wang, Yingbo Li, Chen Di, Tu Liu, Qianlin Hou, Shali Wang
Hypoxic-ischemic encephalopathy (HIE) is a serious clinical problem, responsible for many cases of motor impairment, cognitive deficits, and mortality. Transient receptor potential canonical (TRPC) channels are nonselective cation channels that play a role in many disorders, including trauma, pulmonary hypertension, and excitotoxicity. However, the properties and underlying mechanisms of TRPC channels in HIE are still controversial. Extracellular signal-regulated kinase (ERK) and mammalian target of rapamycin (mTOR) are central signaling pathways that transmit signals from extracellular to intracellular agents and mediate prosurvival, proliferation, and motility proteins...
September 28, 2016: Neuroreport
https://www.readbyqxmd.com/read/27501717/current-therapeutic-drugs-against-cerebral-vasospasm-after-subarachnoid-hemorrhage-a-comprehensive-review-of-basic-and-clinical-studies
#19
Shu Hasegawa, Yu Hasegawa, Masaki Miura
BACKGROUND: Cerebral vasospasm (CVS) is well known as a major complication in subarachnoid hemorrhage (SAH) patients, and research has long been focused on improving morbidity and mortality. As CVS commonly develops from day 4 to day 14 after SAH onset, SAH patients require therapies with drugs for preventing CVS after surgical treatment for the source of hemorrhage, mostly ruptured intracranial aneurysms. It is thought that the pathogenesis of CVS is initiated by prolonged smooth muscle contraction, and the subsequent hypoperfusion and cytotoxic responses induce cerebral ischemia...
August 8, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/27491382/acupuncture-for-amnestic-mild-cognitive-impairment-a-meta-analysis-of-randomised-controlled-trials
#20
Min Deng, Xu-Feng Wang
OBJECTIVE: Mild cognitive impairment (MCI) is a pre-dementia state; 5-10% of cases per year will evolve into dementia. MCI can be amnestic (AMCI) or non-amnestic. AMCI is associated with a higher risk of progression. In recent years, interest in acupuncture as a potential treatment for AMCI has grown. The aim of this meta-analysis was to estimate the clinical effectiveness and safety of acupuncture for AMCI. METHODS: Randomised controlled trials (RCTs) of acupuncture versus medical treatment for AMCI were identified using the following databases from inception to July 2015: PubMed; Medline; CENTRAL; Chinese Scientific Journal Database; The Chinese Acupuncture Trials Register; China National Knowledge Infrastructure (CNKI); and Wanfang database...
October 2016: Acupuncture in Medicine: Journal of the British Medical Acupuncture Society
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