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Colorectal liver metastases

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https://www.readbyqxmd.com/read/29135089/fak-src-and-p-paxillin-expression-is-decreased-in-liver-metastasis-of-colorectal-carcinoma-patients
#1
Eleftherios Mantonakis, Constantinos Giaginis, Emmanouel Pikoulis, Evangelos Felekouras, Efstratios Patsouris, Theodoros Liakakos, Efstathios Papalampros, Stamatios Theocharis
PURPOSE: The FAK/Src/Paxillin (PXN) axis has been implicated in malignant transformation, tumor growth, progression and metastasis. The present study aimed to assess FAK/Src/PXN protein expression in both primary and liver metastatic sites of colorectal adenocarcinoma (CRC). METHODS: FAK, Src and p-PXN expression was assessed immunohistochemically on 32 primary CRCs and their corresponding liver metastases, being also analyzed in relation with clinicopathological characteristics and patient survival...
September 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29133238/mir-146a-targets-c-met-and-abolishes-colorectal-cancer-liver-metastasis
#2
Anne-Marie Bleau, Miriam Redrado, Estanislao Nistal-Villan, Maria Villalba, Francisco Exposito, Esther Redin, Arrate L de Aberasturi, Leyre Larzabal, Javier Freire, Javier Gomez-Roman, Alfonso Calvo
A major complication of colorectal cancer (CRC), one of the most frequent and deadly types of cancer, is disease progression via liver metastases. At this stage, very few treatment options are available for patients, and the disease remains incurable. Herein, we used a well-established mouse model of CRC liver metastasis (CLM) to identify new regulators of this process. Using serial transplantation of murine MC38 adenocarcinoma cells, we obtained liver metastatic variants that displayed extremely strong colonization abilities...
November 10, 2017: Cancer Letters
https://www.readbyqxmd.com/read/29131348/the-value-of-contrast-enhanced-laparoscopic-ultrasound-during-robotic-assisted-surgery-for-primary-colorectal-cancer
#3
Signe Bremholm Ellebaek, Claus Wilki Fristrup, Torsten Pless, Peiman Hossein Poornoroozy, Per Vadgaard Andersen, Bassam Mahdi, Michael Bau Mortensen
AIM: The aim of this study was to assess the potential clinical value of contrast enhanced laparoscopic ultrasonography (CE-LUS) as a screening modality for liver metastases during robotic assisted surgery for primary colorectal cancer (CRC). METHOD: A prospective, descriptive (feasibility) study including 50 consecutive patients scheduled for robotic assisted surgery for primary CRC. CE-LUS was performed by 2 experienced specialists. Only patients without metastatic disease were included...
November 13, 2017: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/29126672/does-portal-vein-embolization-prior-to-liver-resection-influence-the-oncological-outcomes-a-propensity-score-matched-comparison
#4
Joost Huiskens, Pim B Olthof, Eric P van der Stok, Thomas Bais, Krijn P van Lienden, Adriaan Moelker, Jan Krumeich, Rudi M Roumen, Dirk J Grünhagen, Cornelis J A Punt, Martin van Amerongen, Johannes H W de Wilt, Cornelis Verhoef, Thomas M Van Gulik
INTRODUCTION: There is an ongoing controversy surrounding portal vein embolization (PVE) regarding the short-term safety of PVE and long-term oncological benefit. This study aims to compare survival outcomes of patients subjected to major liver resection for colorectal liver metastases (CRLM) with or without PVE. METHODS: All consecutive patients who underwent major liver resection for CRLM in four high volume liver centres between January 2000 and December 2015 were included...
September 20, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29125233/in-vivo-imaging-xenograft-models-for-the-evaluation-of-anti-brain-tumor-efficacy-of-targeted-drugs
#5
Kenji Kita, Sachiko Arai, Akihiro Nishiyama, Hirokazu Taniguchi, Koji Fukuda, Rong Wang, Tadaaki Yamada, Shinji Takeuchi, Shoichiro Tange, Atsushi Tajima, Mitsutoshi Nakada, Kazuo Yasumoto, Yoshiharu Motoo, Takashi Murakami, Seiji Yano
Molecular-targeted drugs are generally effective against tumors containing driver oncogenes, such as EGFR, ALK, and NTRK1. However, patients harboring these oncogenes frequently experience a progression of brain metastases during treatment. Here, we present an in vivo imaging model for brain tumors using human cancer cell lines, including the EGFR-L858R/T790M-positive H1975 lung adenocarcinoma cells, the NUGC4 hepatocyte growth factor (HGF)-dependent gastric cancer cells, and the KM12SM colorectal cancer cells containing the TPM3-NTRK1 gene fusion...
November 10, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/29117361/re-local-treatment-of-unresectable-colorectal-liver-metastases-results-of-a-randomized-phase-ii-trial
#6
Fergus Macbeth, Vern Farewell, Tom Treasure
No abstract text is available yet for this article.
October 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29113730/conversion-to-resection-in-patients-receiving-systemic-chemotherapy-for-unresectable-and-or-metastatic-colorectal-cancer-predictive-factors-and-prognosis
#7
Hiroaki Nozawa, Soichiro Ishihara, Kazushige Kawai, Keisuke Hata, Tomomichi Kiyomatsu, Toshiaki Tanaka, Takeshi Nishikawa, Kensuke Otani, Koji Yasuda, Kazuhito Sasaki, Manabu Kaneko, Koji Murono
BACKGROUND: Systemic chemotherapy increases the possibility of resection in patients with initially unresectable colorectal cancer (CRC), especially patients with hepatic metastasis. However, the predictive factors and prognosis of conversion to resection after chemotherapy in patients with various organ metastases remain largely unknown. PATIENTS AND METHODS: We reviewed the data from metastatic CRC (mCRC) patients who had received oxaliplatin- or irinotecan-based systemic chemotherapy from 2005 to 2016...
October 19, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/29113675/surgery-induced-tumor-growth-in-metastatic-colorectal-cancer
#8
REVIEW
Klaas M Govaert, Jennifer M J Jongen, Onno Kranenburg, Inne H M Borel Rinkes
Metastatic colorectal cancer (mCRC) is a devastating disease causing 700.000 deaths annually worldwide. Metastases most frequently develop in the liver. Partial hepatectomy has dramatically improved clinical outcome and is the only curative treatment option for eligible patients with mCRC. Pre-clinical studies have shown that surgical procedures can have tumor-promoting local 'side-effects' such as hypoxia and inflammation, thereby altering the behaviour of residual tumor cells. In addition, systemically released factors following (colon or liver) surgery can act as a wakeup-call for dormant tumor cells in distant organs and/or help establish a pre-metastatic niche...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29113656/introduction-of-the-resection-severity-index-as-independent-risk-factor-limiting-survival-after-resection-of-colorectal-liver-metastases
#9
Jill Gwiasda, Harald Schrem, Alexander Kaltenborn, Jan Mahlmann, Heiko Mix, Frank Lehner, Nicolas Kayser, Jürgen Klempnauer, Ulf Kulik
BACKGROUND: The purpose of this study is to evaluate the influence of the recently introduced resection severity index (RSI) in patients with liver resection for hepatocellular carcinoma on survival after resection of colorectal liver metastases. The RSI quantifies pre-operatively the liver cellular damage, liver synthetic function and loss of organ parenchyma. METHODS: All consecutive patients who underwent liver resection for metastases of colorectal cancer (CLM) between 2000 and 2015 were included in this study...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29113650/laparoscopic-parenchymal-preserving-liver-resections-for-colorectal-liver-metastases-in-the-era-of-highly-effective-systemic-therapy-and-selective-internal-radiation-therapy-can-often-prevent-a-hemihepatectomy-with-video
#10
Mathieu D'Hondt, Frédéric Ververken, Frederiek Nuytens
BACKGROUND: Preservation of hepatic parenchyma is important in liver surgery to prevent postoperative liver failure and according to some reports it could offer a prolonged survival and lower recurrence rates compared to major hepatectomies in patients with colorectal liver metastases. However, laparoscopic parenchyma-preserving liver resections can be technically challenging. The aim of this video is to illustrate the concept of laparoscopic parenchymal-preserving liver resections after conversion chemotherapy with targeted therapy...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29107396/parenchymal-sparing-surgery-for-colorectal-liver-metastases-the-need-for-a-common-definition
#11
Marie Desjardin, Grégoire Desolneux, Véronique Brouste, Olivier Degrandi, Benjamin Bonhomme, Marianne Fonck, Yves Becouarn, Dominique Béchade, Serge Evrard
BACKGROUND: The definition of parenchymal sparing surgery (PSS) for colorectal liver metastases (CRLM) diverges requiring a clarification of the concept. METHOD: A consecutive series of patients were treated by PSS for their CRLMs, either by resection or intra-operative ablation (IOA), whenever possible a one-stage surgery and minimal usage of portal vein embolization. Post-operative complications were the primary endpoint with a special focus on post-operative liver failure...
October 16, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29105339/prognostic-value-of-cd133-cd54-cd44-circulating-tumor-cells-in-colorectal-cancer-with-liver-metastasis
#12
Chao Fang, Chuanwen Fan, Cun Wang, Qiaorong Huang, Wentong Meng, Yongyang Yu, Lie Yang, Jiankun Hu, Yuan Li, Xianming Mo, Zongguang Zhou
In the previous study, we had showed the expression of CD133(+) CD54(+) CD44(+) cellular subpopulation of circulating tumor cells (CTCs) was significantly associated with liver metastasis of colorectal cancer (CRC). This study aimed to explore whether this subpopulation of CTCs have a prognostic value in CRC patients. Flow cytometry was used to detect the expression of cellular subpopulations of CTCs with CD133, CD54, and CD44 in 152 CRC patients, between December 2013 and October 2014. The impact of clinicopathological factors and the expression of cellular subpopulations of CTCs on overall survival were then analyzed...
November 3, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/29100312/molecular-signatures-reflecting-microenvironmental-metabolism-and-chemotherapy-induced-immunogenic-cell-death-in-colorectal-liver-metastases
#13
Olga Østrup, Vegar Johansen Dagenborg, Einar Andreas Rødland, Veronica Skarpeteig, Laxmi Silwal-Pandit, Krzysztof Grzyb, Audun Elnæs Berstad, Åsmund Avdem Fretland, Gunhild Mari Mælandsmo, Anne-Lise Børresen-Dale, Anne Hansen Ree, Bjørn Edwin, Vigdis Nygaard, Kjersti Flatmark
Background: Metastatic colorectal cancer (CRC) is associated with highly variable clinical outcome and response to therapy. The recently identified consensus molecular subtypes (CMS1-4) have prognostic and therapeutic implications in primary CRC, but whether these subtypes are valid for metastatic disease is unclear. We performed multi-level analyses of resectable CRC liver metastases (CLM) to identify molecular characteristics of metastatic disease and evaluate the clinical relevance...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29098384/prognostic-influence-of-hepatic-margin-after-resection-of-colorectal-liver-metastasis-role-of-modern-preoperative-chemotherapy
#14
Frank Makowiec, Peter Bronsert, Andrea Klock, Ulrich T Hopt, Hannes P Neeff
PURPOSE: Modern chemotherapy (CTX) increases survival in stage IV colorectal cancer. In colorectal liver metastases (CLM), neoadjuvant (neo) CTX may increase resectability and improve survival. Due to widespread use of CTX in CLM, recent studies assessed the role of the hepatic margin after CTX, with conflicting results. We evaluated the outcome after resection of CLM in relation to CTX and hepatic resection status. METHODS: Since 2000, 334 patients with first hepatic resection for isolated CLM were analyzed...
November 2, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29080924/exploratory-analyses-assessing-the-impact-of-early-tumour-shrinkage-and-depth-of-response-on-survival-outcomes-in-patients-with-ras-wild-type-metastatic-colorectal-cancer-receiving-treatment-in-three-randomised-panitumumab-trials
#15
Julien Taieb, Fernando Rivera, Salvatore Siena, Meinolf Karthaus, Manuel Valladares-Ayerbes, Javier Gallego, Michael Geissler, Reija Koukakis, Gaston Demonty, Marc Peeters
PURPOSE: To report exploratory analyses of early tumour shrinkage (ETS) and depth of response (DpR) in patients with RAS wild-type (WT) metastatic colorectal cancer (mCRC), receiving the first-line treatment in three randomised panitumumab trials. METHODS: Data from the PRIME (NCT00364013), PEAK (NCT00819780) and PLANET (NCT00885885) studies were included. Median DpR, the proportion of patients achieving ETS ≥ 20% or ≥ 30% at week 8, and the impact of ETS and DpR (including by category) on outcome were analysed...
October 28, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29078882/safety-and-efficacy-of-combined-resection-of-colorectal-peritoneal-and-liver-metastases
#16
Stephanie Downs-Canner, Yongli Shuai, Lekshmi Ramalingam, James F Pingpank, Matthew P Holtzman, Herbert J Zeh, David L Bartlett, Haroon A Choudry
BACKGROUND: To determine if a select subgroup of patients with combined liver and peritoneal colorectal metastases would derive oncologic benefit from surgical resection as a component of multimodality treatment. MATERIALS AND METHODS: We retrospectively compared 32 patients with combined colorectal peritoneal and liver metastases (CRLM) and 173 patients with peritoneal metastases only (CRPM) undergoing cytoreductive surgery with hyperthermic intraperitoneal chemoperfusion (CRS-HIPEC)...
November 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/29076812/surgical-outcomes-in-patients-with-hepatic-synchronous-and-metachronous-colorectal-metastasis
#17
Maria Laura Cossu, Giorgio Carlo Ginesu, Claudio Francesco Feo, Alessandro Fancellu, Antonio Pinna, Isabel Vargiu, Francesca Addis, Michele Barmina, Giovanni Sotgiu, Alberto Porcu
AIM: To evaluate the impact of several clinical and pathological factors on the outcomes of surgery for hepatic colorectal cancer metastasis. METHODS: Eighty-four liver metastasectomies in 77 consecutive patients with 90 colorectal cancer hepatic metastases were performed in our institution from 2009 to 2014. Surgery was carried out in 75 cases, as two patients were not eligible for surgery. Among them 43 (Group A) were affected by synchronous, and 32 (Group B) by metachronous lesions...
October 25, 2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29075968/laparoscopic-parenchymal-sparing-resections-in-segment-8-techniques-for-a-demanding-and-infrequent-procedure
#18
David Martínez-Cecilia, Martina Fontana, Najaf N Siddiqi, Mark Halls, Salvatore Barbaro, Mohammad Abu-Hilal
BACKGROUND: Laparoscopic liver resections for lesions in the postero-superior segments are technically demanding due their deep location and relation with the vena cava. However, previous reports have demonstrated the feasibility and safety of these resections in centres with advanced experience in laparoscopic liver surgery. In this case series, we present our results and experience of laparoscopic parenchymal sparing liver resections of lesions in segment 8. METHODS: All patients undergoing laparoscopic liver resections of segment 8 lesions, alone or combined with other liver resections, between August 2003 and July 2016 were included...
October 26, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29072417/prediction-of-response-to-irinotecan-and-drug-toxicity-based-on-pharmacogenomics-test-a-prospective-case-study-in-advanced-colorectal-cancer
#19
A H Emami, S Sadighi, R Shirkoohi, M A Mohagheghi
Background: FOLFIRI regimen, which is composed of 5-FU, Leucovorin, and Irinotecan, is used in the first-line chemotherapy of metastatic colorectal cancer. Irinotecan life threatening toxicity is partly related to cytotoxic drug metabolite which is primarily inactivated by the UGT1A1 enzyme. The primary aim of the present research was to find the correlation between UGT1A1-genotype and clinical toxicity of irinotecan. Methods: In a prospective study from March 2011 to December 2013, all patients with metastatic colorectal cancer who had been referred to Medical Oncology Department of Iran Cancer Institute were genotyped for UGT1A1*28 before the first cycle of chemotherapy...
October 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29071660/impact-of-ras-mutations-in-metastatic-colorectal-cancer-after-potentially-curative-resection-does-site-of-metastases-matter
#20
Guillaume Passot, Bradford J Kim, Olivier Glehen, Reza J Mehran, Scott E Kopetz, Diane Goere, Michael J Overman, Marc Pocard, Frédéric Marchal, Claudius Conrad, Thomas A Aloia, Jean-Nicolas Vauthey, Yun Shin Chun
BACKGROUND: RAS mutation status is an important prognostic factor after resection of liver metastases (LiM) from colorectal cancer (CRC). The prognostic significance of RAS after resection of lung (LuM) and peritoneal (PM) metastases from CRC is unknown. METHODS: Between 2005 and 2014, all consecutive patients with known RAS status who underwent potentially curative resection for LiM, LuM, or PM were evaluated. RESULTS: A total of 720 patients with known RAS status underwent resection of LiM (n = 468), LuM (n = 102), and PM (n = 150)...
October 25, 2017: Annals of Surgical Oncology
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