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Colorectal liver metastases

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https://www.readbyqxmd.com/read/28728304/-percutaneous-microwave-radiofrequency-ablation-liver-partition-and-portal-vein-embolization-for-planned-hepatectomy-for-colorectal-liver-metastases-with-insufficient-future-liver-remnant
#1
Y B Zhang, D F Hong, X M Fan, Z Y Luo, G L Shen
No abstract text is available yet for this article.
July 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28728167/long-term-outcomes-of-patients-with-10-or-more-colorectal-liver-metastases
#2
M A Allard, R Adam, F Giuliante, R Lapointe, C Hubert, J N M Ijzermans, D F Mirza, D Elias, C Laurent, T Gruenberger, G Poston, C Letoublon, H Isoniemi, V Lucidi, I Popescu, J Figueras
BACKGROUND: Although the number of colorectal liver metastases (CLM) is decreasingly considered as a contraindication to surgery, patients with 10 CLM or more are often denied liver surgery. This study aimed to evaluate the outcome after liver surgery and to identify prognostic factors of survival in such patients. METHODS: The study population consisted of a multicentre cohort of patients with CLM (N=12 406) operated on, with intention to resect, from January 2005-June 2013 and whose data were prospectively collected in the LiverMetSurvey registry...
July 20, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28725278/asco-2016-update-colorectal-liver-metastases
#3
REVIEW
Klaus Kaczirek
This short review summarizes the most relevant data on colorectal liver metastases (CLM) presented at the 2016 Annual Meeting of the American Society of Clinical Oncology (ASCO). For this update, congress abstracts were grouped into three clinically relevant scenarios: CLM that are deemed upfront resectable, borderline resectable, and primarily unresectable. According to a large registry study, small, upfront resectable, solitary CLM should be resected using a parenchymal sparing technique. A prospective noninterventional study suggested that chemotherapy plus the anti-VEGF (vascular endothelial growth factor) antibody bevacizumab is effective and well tolerated in patients with borderline resectable CLM...
2017: Memo
https://www.readbyqxmd.com/read/28725043/mucin-2-silencing-promotes-colon-cancer-metastasis-through-interleukin-6-signaling
#4
Hui-Ping Hsu, Ming-Derg Lai, Jenq-Chang Lee, Meng-Chi Yen, Tzu-Yang Weng, Wei-Ching Chen, Jung-Hua Fang, Yi-Ling Chen
Downregulation of Mucin 2 (MUC2) expression is associated with early carcinogenesis events in colon cancer. MUC2 plays a role in the progression of colon cancer, and reduced MUC2 protein expression correlates with increased interleukin-6 (IL-6) expression. However, the interaction between MUC2 and IL-6 in colorectal cancer metastasis remains unclear. We systematically analyzed MUC2 and IL-6 expression and determined the survival of cancer patients with high or low MUC2 and IL-6 expression using the Oncomine and PrognoScan databases, respectively...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28721098/patient-selection-for-cytoreductive-surgery-and-hipec-for-the-treatment-of-peritoneal-metastases-from-colorectal-cancer
#5
REVIEW
Geert A Simkens, Koen P Rovers, Simon W Nienhuijs, Ignace H de Hingh
Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is a viable option for selected patients with peritoneal metastases (PM) from colorectal origin, resulting in long-term survival and even cure in some cases. However, adequate patient selection for this treatment is currently one of the major challenges. The aim of this review is to provide a comprehensive overview of clinically relevant factors associated with overall survival. This may help to guide clinicians through the complex interplay of patient, tumor, and treatment characteristics to adequately select patients who benefit the most from this extensive surgical treatment...
2017: Cancer Management and Research
https://www.readbyqxmd.com/read/28717911/laparoscopic-compared-to-open-repeat-hepatectomy-for-colorectal-liver-metastases-a-multi-institutional-propensity-matched-analysis-of-short-and-long-term-outcomes
#6
Julie Hallet, Antonio Sa Cunha, Daniel Cherqui, Brice Gayet, Diane Goéré, Philippe Bachellier, Alexis Laurent, David Fuks, Francis Navarro, Patrick Pessaux
INTRODUCTION: While uptake of laparoscopic hepatectomy has improved, evidence on laparoscopic re-hepatectomy (LRH) for colorectal liver metastases (CRLMs) is limited and has never been compared to the open approach. We sought to define outcomes of LRH compared to open re-hepatectomy (ORH). METHODS: Patients undergoing re-hepatectomy for CRLM at 39 institutions (2006-2013) were identified. Primary outcomes were 30-day post-operative overall morbidity, mortality, and length of stay...
July 17, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28717739/liver-metastasectomy-and-systemic-therapy-improve-overall-survival-compared-with-surgery-alone-after-curative-liver-resection-of-colorectal-metastases-in-a-developing-country-costa-rica
#7
Paula Quesada-Soto, Denis Landaverde, Allan Ramos-Esquivel
BACKGROUND: Resection of liver-isolated metastases of colorectal cancer (CRC) offers the greatest likelihood of cure. Nevertheless, recurrence rates after this procedure are high, and chemotherapy is a reasonable choice with inconclusive evidence. We aimed to determine if there is a survival difference between patients receiving systemic therapy with surgery versus surgery alone for resection of liver metastases. METHODS: From a source population of 170 patients treated in our National Centre (Centro Nacional de Cirugía Hepatobiliar, San José, Costa Rica), with liver metastases from various primary sites, we selected 51 patients with CRC who underwent hepatic resection with curative intent...
February 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/28712693/diagnostic-performance-of-contrast-enhanced-ct-scan-in-sinusoidal-obstruction-syndrome-induced-by-chemotherapy-of-colorectal-liver-metastases-radio-pathological-correlation
#8
Sophie Cayet, Jeremy Pasco, Fanny Dujardin, Marie Besson, Isabelle Orain, Anne De Muret, Elodie Miquelestorena-Standley, Julien Thiery, Thibaud Genet, Anne-Gwenn Le Bayon
PURPOSE: Sinusoidal obstruction syndrome (SOS) is a likely side effect of colorectal liver metastases (CRLM) chemotherapy. This study aimed to assess computed tomography scan (CT-scan) performance for SOS diagnosis for patients receiving neoadjuvant chemotherapy (NC) prior to CRLM surgery, comparing obtained results with pathological gold standard. METHODS: Preoperative CT-scans of 67 patients who had received a NC prior to liver resection for CRLM from 2011 to 2016 were retrospectively analysed...
July 3, 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28709876/is-cure-possible-after-sequential-resection-of-hepatic-and-pulmonary-metastases-from-colorectal-cancer
#9
Muthukumarassamy Rajakannu, Pierre Magdeleinat, Eric Vibert, Oriana Ciacio, Gabriella Pittau, Pasquale Innominato, Antonio SaCunha, Daniel Cherqui, Jean-François Morère, Denis Castaing, René Adam
BACKGROUND: Surgical resection is an established therapeutic strategy for colorectal cancer (CRC) metastasis. However, controversies exist when CRC liver and lung metastases (CLLMs) are found concomitantly or when recurrence develops after either liver or lung resection. No predictive score model is available to risk stratify these patients in preparation for surgery, and cure has not yet been reported. PATIENTS AND METHODS: All consecutive patients who had undergone surgery for CLLMs at our institution during a 20-year period were reviewed...
June 23, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/28707960/biofunctionalized-hybrid-magnetic-gold-nanoparticles-as-catalysts-for-photothermal-ablation-of-colorectal-liver-metastases
#10
Sarah B White, Dong-Hyun Kim, Yang Guo, Weiguo Li, Yihe Yang, Jeane Chen, Venkateswara R Gogineni, Andrew C Larson
Purpose To demonstrate that anti-MG1 conjugated hybrid magnetic gold nanoparticles (HNPs) act as a catalyst during photothermal ablation (PTA) of colorectal liver metastases, and thus increase ablation zones. Materials and Methods All experiments were performed with approval of the institutional animal care and use committee. Therapeutic and diagnostic multifunctional HNPs conjugated with anti-MG1 monoclonal antibodies were synthesized, and the coupling efficiency was determined. Livers of 19 Wistar rats were implanted with 5 × 10(6) rat colorectal liver metastasis cell line cells...
July 13, 2017: Radiology
https://www.readbyqxmd.com/read/28707010/-liver-resection-for-colorectal-metastases-in-elderly-patients
#11
F Rauchfuß, U Settmacher
No abstract text is available yet for this article.
July 13, 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/28699599/significance-of-selected-morphological-and-histopathological-parameters-of-colon-tumors-as-prognostic-factors-of-cancer-spread
#12
Zbigniew Krzysztof Kamocki, Natalia Anna Wodyńska, Joanna Laura Żurawska, Konrad Piotr Zaręba
BACKGROUND/AIMS: The identification of prognostic factors of metastatic development is one of the most important issues in colorectal cancer (CRC) research. The aim of this study was to determine the usefulness of colon tumor characteristics, including location, circumferential location, histological type, and histological grade, as predictors of metastases. MATERIALS AND METHODS: To identify potential predictors of CRC spread, we analyzed data of 191 patients who had undergone surgery for colon tumors...
July 2017: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/28695424/flt-pet-for-early-response-evaluation-of-colorectal-cancer-patients-with-liver-metastases-a-prospective-study
#13
Marie Benzon Mogensen, Annika Loft, Marianne Aznar, Thomas Axelsen, Ben Vainer, Kell Osterlind, Andreas Kjaer
BACKGROUND: Fluoro-L-thymidine (FLT) is a positron emission tomography/computed tomography (PET/CT) tracer which reflects proliferative activity in a cancer lesion. The main objective of this prospective explorative study was to evaluate whether FLT-PET can be used for the early evaluation of treatment response in colorectal cancer patients (CRC) with liver metastases. Patients with metastatic CRC having at least one measurable (>1 cm) liver metastasis receiving first-line chemotherapy were included...
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28695393/the-prognostic-impact-of-determining-resection-margin-status-for-multiple-colorectal-metastases-according-to-the-margin-of-the-largest-lesion
#14
Kazunari Sasaki, Georgios A Margonis, Kosuke Maitani, Nikolaos Andreatos, Jaeyun Wang, Emmanouil Pikoulis, Jin He, Christopher L Wolfgang, Matthew Weiss, Timothy M Pawlik
BACKGROUND: Although the prognostic role of surgical margin status after resection of colorectal liver metastasis (CRLM) has been previously examined, controversy still surrounds the importance of surgical margin status in patients with multiple tumors. METHODS: Patients who underwent curative-intent surgery for CRLM from 2000 to 2015 and who presented with multiple tumors were identified. Patients with R1 resection status determined by the closest resection margin of the non-largest tumor were classified as R1-Type 1; patients with R1 status determined by the resection margin of the largest tumor were defined as R1-Type 2...
July 10, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28693191/effect-of-primary-tumor-location-and-tumor-size-on-the-response-to-radiotherapy-for-liver-metastases-from-colorectal-cancer
#15
Hiroshi Doi, Kenji Uemoto, Osamu Suzuki, Koichi Yamada, Norihisa Masai, Daisaku Tatsumi, Hiroya Shiomi, Ryoong-Jin Oh
Metastatic liver tumors (MLTs) from colorectal cancer (CRC) are often treated with stereotactic body radiation therapy (SBRT). The present study aimed to examine the predictive factors for response of MLTs to SBRT. A total of 39 MLTs from 24 patients with CRC were retrospectively analyzed. Radiotherapy for MLT was typically performed with a prescribed dose equivalent to a biologically effective dose (BED)10 of 100 Gy. The median follow-up period was 16 months (range, 5-64 months). The median prescribed dose and total BED10 were 56 Gy (range, 45-72 Gy) and 97...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28692036/neoadjuvant-chemotherapy-affects-molecular-classification-of-colorectal-tumors
#16
K Trumpi, I Ubink, A Trinh, M Djafarihamedani, J M Jongen, K M Govaert, S G Elias, S R van Hooff, J P Medema, M M Lacle, L Vermeulen, I H M Borel Rinkes, O Kranenburg
The recent discovery of 'molecular subtypes' in human primary colorectal cancer has revealed correlations between subtype, propensity to metastasize and response to therapy. It is currently not known whether the molecular tumor subtype is maintained after distant spread. If this is the case, molecular subtyping of the primary tumor could guide subtype-targeted therapy of metastatic disease. In this study, we classified paired samples of primary colorectal carcinomas and their corresponding liver metastases (n=129) as epithelial-like or mesenchymal-like, using a recently developed immunohistochemistry-based classification tool...
July 10, 2017: Oncogenesis
https://www.readbyqxmd.com/read/28689154/if-a-picture-is-worth-a-thousand-words-take-a-good-look-at-the-picture-survival-after-liver-metastasectomy-for-colorectal-cancer
#17
Eva Morris, Tom Treasure
INTRODUCTION: An analysis of NHS data published in by Morris et al. in 2010 is widely used as evidence in support of liver metastasectomy for colorectal cancer and its wider application. Recent evidence concerning better overall survival for patients with metastatic colorectal cancer challenges the notional assumptions about what survival would be without metastasectomy. Earlier detection of metastases for local treatments has not resulted in a survival benefit. MATERIALS AND METHODS: The interpretation of its central graphical display is critically reviewed and the common the limitations of the analysis of registry data and resulting immortal time bias are explored...
July 7, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28688518/neutrophil-to-lymphocyte-ratio-predicts-prognosis-after-neoadjuvant-chemotherapy-and-resection-of-intrahepatic-cholangiocarcinoma
#18
Kiyohiko Omichi, Jordan M Cloyd, Suguru Yamashita, Ching-Wei D Tzeng, Claudius Conrad, Yun Shin Chun, Thomas A Aloia, Jean-Nicolas Vauthey
BACKGROUND: Previous studies have demonstrated a strong association between the preoperative neutrophil-to-lymphocyte ratio and the outcomes of patients with resected hepatocellular carcinoma and colorectal liver metastases. However, the predictive ability of neutrophil-to-lymphocyte ratio in patients with intrahepatic cholangiocarcinoma, especially those treated with preoperative chemotherapy, has been less well described. METHODS: The clinicopathological characteristics, overall survival, and recurrence free survival of all patients with intrahepatic cholangiocarcinoma resected between 2000-2015, were compared between those with elevated (≥3...
July 5, 2017: Surgery
https://www.readbyqxmd.com/read/28687147/radiofrequency-ablation-compared-to-surgical-resection-for-curative-treatment-of-patients-with-colorectal-liver-metastases-a-meta-analysis
#19
REVIEW
Martinus J van Amerongen, Sjoerd F M Jenniskens, Peter B van den Boezem, Jurgen J Fütterer, Johannes H W de Wilt
BACKGROUND: Hepatic resection and ablative treatments, such as RFA are available treatment options for liver tumors. Advantages and disadvantages of these treatment options in patients with colorectal liver metastases need further evaluation. The purpose of this study was to systematically evaluate the role of radiofrequency ablation (RFA) compared to surgery in the curative treatment of patients with colorectal liver metastases (CRLM). METHODS: A systematic search was performed from MEDLINE, EMBASE and the Cochrane Library for studies directly comparing RFA with resection for CRLM, after which variables were evaluated...
July 4, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28687024/brain-metastases-from-colorectal-cancer-characteristics-and-management
#20
REVIEW
Diane Mege, Arnaud Sans, Mehdi Ouaissi, Antonio Iannelli, Igor Sielezneff
BACKGROUND: Brain metastases (BMs) are the most common intracranial neoplasms in adults, but they rarely arise from colorectal cancer (CRC). The objective of this study was to report an overview of the characteristics and current management of CRC BMs. METHODS: A systematic review on CRC BMs was performed using Medline database from 1983 to 2015. The search was limited to studies published in English. Review articles, not relevant case report or studies or studies relating to animal and in vitro experiments were excluded...
July 7, 2017: ANZ Journal of Surgery
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