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mechanism of leucopenia in dengue

Gopinathan Pillai Sreekanth, Aporn Chuncharunee, Aunchalee Sirimontaporn, Jutatip Panaampon, Sansanee Noisakran, Pa-Thai Yenchitsomanus, Thawornchai Limjindaporn
Dengue virus (DENV) infection causes organ injuries, and the liver is one of the most important sites of DENV infection, where viral replication generates a high viral load. The molecular mechanism of DENV-induced liver injury is still under investigation. The mitogen activated protein kinases (MAPKs), including p38 MAPK, have roles in the hepatic cell apoptosis induced by DENV. However, the in vivo role of p38 MAPK in DENV-induced liver injury is not fully understood. In this study, we investigated the role of SB203580, a p38 MAPK inhibitor, in a mouse model of DENV infection...
2016: PloS One
Gopinathan Pillai Sreekanth, Aporn Chuncharunee, Aunchalee Sirimontaporn, Jutatip Panaampon, Chatchawan Srisawat, Atthapan Morchang, Shilu Malakar, Peti Thuwajit, Suwattanee Kooptiwut, Aroonroong Suttitheptumrong, Pucharee Songprakhon, Sansanee Noisakran, Pa-Thai Yenchitsomanus, Thawornchai Limjindaporn
The liver is considered to be an important organ of dengue virus (DENV) replication and pathogenesis. However, molecular mechanisms of hepatic injury are still poorly understood. Modulation of Mitogen Activated Protein Kinases (MAPKs) was previously shown to affect DENV-induced apoptosis of hepatocytes in vitro. However, the in vivo role of ERK1/2, a member of the MAPK family, and the question whether its activation can facilitate cell survival or cell death, has not been thoroughly investigated. Therefore, the role of ERK1/2 in a mouse model of DENV infection was examined...
August 8, 2014: Virus Research
Kristina B Clark, Nattawat Onlamoon, Hui-Mien Hsiao, Guey C Perng, Francois Villinger
Dengue Virus (DV) infects between 50 and 100 million people globally, with public health costs totaling in the billions. It is the causative agent of dengue fever (DF) and dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS), vector-borne diseases that initially predominated in the tropics. Due to the expansion of its mosquito vector, Aedes spp., DV is increasingly becoming a global problem. Infected individuals may present with a wide spectrum of symptoms, spanning from a mild febrile to a life-threatening illness, which may include thrombocytopenia, leucopenia, hepatomegaly, hemorrhaging, plasma leakage and shock...
2013: Frontiers in Microbiology
T Srichaikul, S Nimmannitya
Dengue fever (DF) and dengue haemorrhagic fever (DHF) are caused by the dengue virus. The major pathophysiological hallmark that distinguishes DHF from DF is plasma leakage as a result of increased vascular permeability. Following this leakage, hypovolaemic shock occurs as a consequence of a critical plasma volume loss. Constant haematological abnormalities occurring in DHF and frequently include bone marrow suppression, leucopenia and thrombocytopenia. An enhanced immune response of the host to a secondary DV infection is a feature of DHF and leads to many consequences...
June 2000: Baillière's Best Practice & Research. Clinical Haematology
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