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Hmgb1 & review

Mathieu Nadeau-Vallee, Dima Obari, Julia Palacios, Marie-Eve Brien, Cyntia Duval, Sylvain Chemtob, Sylvie Girard
Inflammation is central to successful reproduction. In the last decade, important advances have been made in regards to endogenous, and therefore non-infectious, initiators of inflammation which can act through the same receptors as pathogens. These molecules are referred to as damage-associated molecular patterns (DAMPs) and their involvement in reproduction has only recently begun to be unraveled. Even though inflammation is necessary for successful reproduction, untimely activation of inflammatory processes can have devastating impact on pregnancy outcomes...
September 27, 2016: Reproduction: the Official Journal of the Society for the Study of Fertility
Miha Lavric, María Auxiliadora Miranda-García, Dirk Holzinger, Dirk Foell, Helmut Wittkowski
Alarmins are endogenous molecules with homeostatic roles that have reached the focus of research in inflammatory arthritis in the last two decades, mostly due to their ability to indicate tissue related damage after active or passive release from injured cells. From HMGB1, S100A8/A9 and S100A12 proteins, over heat-shock proteins (HSPs) and purine metabolites (e.g. uric acid, ATP) to altered matrix proteins and interleukin-33 (IL-33), a number of alarmins have been determined until now as having a role in rheumatoid arthritis, psoriatic and juvenile idiopathic arthritis, as well as spondyloarthritis and gout...
September 19, 2016: Joint, Bone, Spine: Revue du Rhumatisme
María José García Cebrián, Monika Bauden, Roland Andersson, Stefan Holdenrieder, Daniel Ansari
Pancreatic cancer has a dismal prognosis and there is an increasing and unmet need to identify better diagnostic and therapeutic targets in order to ameliorate the course of the disease. HMGB1, a nuclear DNA-binding protein that acts as a transcription factor, is currently in the limelight. HMGB1 exhibits a dual role in pancreatic cancer; when intracellular, it acts as an anti-tumor protein stabilizing the genome, whereas extracellular HMGB1 behaves as a pro-tumor protein with cytokine, chemokine and growth factor functions...
September 2016: Anticancer Research
Sherman S Leung, Josephine M Forbes, Danielle J Borg
The receptor for advanced glycation end products (RAGE) is a novel protein increasingly studied in the pathogenesis of type 1 diabetes (T1D). RAGE is expressed by several immune cell types, including T cells, antigen-presenting cells, endothelial cells, and the endocrine cells of the pancreatic islets. RAGE binds various ligands including advanced glycation end products (AGEs), high-mobility group box protein 1 (HMGB1), S100 proteins, β-amyloid, β-sheet fibrils, and lipopolysaccharide. AGEs are a particularly interesting ligand because their exogenous introduction into the body can be accelerated by the consumption of AGE-rich processed foods...
October 2016: Current Diabetes Reports
Shibo Ying, Xiang Xiao, Tianhui Chen, Jianlin Lou
High mobility group box 1 (HMGB1), which has become one of the most intriguing molecules in inflammatory disorders and cancers and with which ligand-activated peroxisome proliferator-activated receptors (PPARs) are highly associated, is considered as a therapeutic target. Of particular interest is the fact that certain PPAR ligands have demonstrated their potent anti-inflammatory activities and potential anticancer effects. In this review article we summarize recent experimental evidence that PPAR ligands function as suppressors that target biological actions of HMGB1, including intracellular expression, receptor signaling cascades, and extracellular secretion of HMGB1 in cell lines and/or animal models...
2016: PPAR Research
Peter Vandenabeele, Katrien Vandecasteele, Claus Bachert, Olga Krysko, Dmitri V Krysko
For many years it has been thought that apoptotic cells rapidly cleared by phagocytic cells do not trigger an immune response but rather have anti-inflammatory properties. However, accumulating experimental data indicate that certain anticancer therapies can induce an immunogenic form of apoptosis associated with the emission of damage-associated molecular patterns (DAMPs), which function as adjuvants to activate host antitumor immune responses. In this review, we will first discuss recent advances and the significance of danger signaling pathways involved in the emission of DAMPs, including calreticulin, ATP, and HMGB1...
2016: Advances in Experimental Medicine and Biology
Sante Di Gioia, Carla Sardo, Stefano Castellani, Barbara Porsio, Giuliana Belgiovine, Annalucia Carbone, Gaetano Giammona, Gennara Cavallaro, Massimo Conese
Asthma, chronic obstructive pulmonary disease, cystic fibrosis, and idiopathic pulmonary fibrosis, are among the most common chronic diseases and their prevalence is increasing. Each of these diseases is characterized by the secretion of cytokines and pro-inflammatory molecules which are thought to play a critical role in their pathogenesis. Moreover, immune cells, particularly neutrophils, macrophages and dendritic cells as well structural cells such as epithelial and airway smooth muscle cells are also involved in the pathogenic cycle of these diseases...
August 24, 2016: Current Drug Delivery
Xiaoli Zhang, Jinming Yu, Minghuan Li, Hui Zhu, Xindong Sun, Li Kong
BACKGROUND: The association of high mobility group box 1 (HMGB1) expression with clinicopathological significance and prognosis in Asian patients with colorectal carcinoma (CRC) remains controversial. The purpose of this study was to conduct a meta-analysis and literature review to identify the role of HMGB1 in the development and prognosis of CRC in Asians. METHODS: All eligible studies regarding the association between HMGB1 expression in tissue with clinicopathological significance and prognosis in Asian patients with CRC published up to January 2015 were identified by searching PubMed, Web of Science, Chinese National Knowledge Infrastructure, and WanFang database...
2016: OncoTargets and Therapy
Xiaodi Tian, Zhong Wang, Gang Chen
High mobility group box-1 (HMGB1), a highly conserved nonhistone nuclear protein, is widely expressed in most eukaryotic cells including neural cells. Nuclear HMGB1 stabilize nucleosome formation and facilitates gene transcription. HMGB1 can be passively released from necrotic cells or actively secreted from stimulated immune cells. Extracellular HMGB1 interacts with receptors, including the receptor for advanced glycation endproducts (RAGEs), Toll-like receptor 2 (TLR2) and TLR4. After brain injury, HMGB1 is released early from neural cells and contribute to the early stages of the inflammatory response...
August 8, 2016: Current Drug Delivery
In Ah Park, Sun-Hee Heo, In Hye Song, Young-Ae Kim, Hye Seon Park, Won Seon Bang, Suk Young Park, Jeong-Hyon Jo, Hee Jin Lee, Gyungyub Gong
BACKGROUND: Although the prognostic and predictive significance of tumor-infiltrating lymphocytes (TILs) in triple-negative breast cancer (TNBC) have been shown, the cause of the TIL influx is unclear. Here, we investigated whether extracellular secretion of HMGN1 is associated with TIL influx, as well as increased endoplasmic reticulum stress (ERS), in human TNBC. METHODS: We reviewed the slides of 767 patients with TNBC and evaluated the TIL levels. We also assessed the expression of HMGs and several ERS-associated molecules using immunohistochemical staining...
August 2, 2016: Oncotarget
Jiaxin Wei, Ying Zhang, Xiaoyuan Ma, Lixing Tian, Huaping Liang
High mobility group protein B1 (HMGB1) is the most representative substance in the alarmins family, it is actively or passively release to extracellular by the activation of monocyte/macrophage and the dead cells, and then it stimulates the production of a variety of inflammatory mediators, and increases the organism's inflammatory response through relevant receptors signaling pathways. In recent years, its concentration can reflect the severity of inflammation and injury and was related to the prognosis, HMGB1 has won more and more attention in the development of sepsis...
August 2016: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Quansong Xia, Juan Xu, Huoying Chen, Yanzhang Gao, Feili Gong, Liya Hu, Li Yang
BACKGROUND: HMGB1 has been overexpressed in the tissues or serum of patients with non-small-cell lung cancer (NSCLC) in several studies. However, the results remain inconsistent. OBJECTIVE: The aim of this study was to perform a meta-analysis to investigate the relationship between elevated level of HMGB1 and NSCLC. METHODS: Associated studies were included, and the pooled risk difference and mean difference (MD) together with 95% confidence interval (CI) were calculated...
2016: OncoTargets and Therapy
Tengyun Wu, Wei Zhang, Geliang Yang, Huijun Li, Qi Chen, Ruixiang Song, Lin Zhao
As there are millions of cancer deaths every year, it is of great value to identify applicable prognostic biomarkers. As an important alarm, the prognostic role of high mobility group box 1 (HMGB1) in cancer remains controversial. We aim to assess the association of HMGB1 expression with prognosis in cancer patients. Systematic literature searches of PubMed, Embase and Web of Science databases were performed for eligible studies of HMGB1 as prognostic factor in cancer. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated to evaluate the influence of HMGB1 expression on overall survival (OS) and progression-free survival (PFS) in cancer patients...
July 6, 2016: Oncotarget
Moonindranath Sohun, Huiling Shen
High-mobility group box 1 protein (HMGB1) is a highly conserved, non-histone and ubiquitous chromosomal protein found enriched in active chromatin forming part of the high mobility group family of proteins and is encoded by the HMGB1 gene (13q12) in human beings. It has various intranuclear and extracellular functions. It plays an important role in the pathogenesis of many diseases including cancer. In 2012, there was approximately 1.67 million new breast cancer cases diagnosed which makes it the second most frequent cancer in the world after lung cancer (25% of all cancers) and the commonest cancer among women...
June 2016: Annals of Translational Medicine
Emilie Venereau, Federica De Leo, Rosanna Mezzapelle, Giorgia Careccia, Giovanna Musco, Marco E Bianchi
High Mobility Group Box 1 protein was discovered as a nuclear protein, but it has a "second life" outside the cell where it acts as a damage-associated molecular pattern. HMGB1 is passively released or actively secreted in a number of diseases, including trauma, chronic inflammatory disorders, autoimmune diseases and cancer. Extracellular HMGB1 triggers and sustains the inflammatory response by inducing cytokine release and by recruiting leucocytes. These characteristics make extracellular HMGB1 a key molecular target in multiple diseases...
September 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
Hideo Takahashi, Masahiro Nishibori
High mobility group box protein1 (HMGB1), a ubiquitous chromatin component, is released by necrotic cells, apoptotic cells, and cells in profound distress. HMGB1 plays a critical role as a proinflammatory mediator. HMGB1 represents an important new target for drug development in a variety of inflammatory disorders, including stroke, brain injury, arteriosclerosis, and cancer. The antibodies against HMGB1 and its receptors ar hopeful candidates for immunotherapeutic strategy for treating patients with these diseases...
April 2016: Nihon Rinsho. Japanese Journal of Clinical Medicine
Wenbin Wan, Lan Cao, Ramin Khanabdali, Bill Kalionis, Xiantao Tai, Shijin Xia
Neuropathic pain (NPP) is intolerable, persistent, and specific type of long-term pain. It is considered to be a direct consequence of pathological changes affecting the somatosensory system and can be debilitating for affected patients. Despite recent progress and growing interest in understanding the pathogenesis of the disease, NPP still presents a major diagnostic and therapeutic challenge. High mobility group box 1 (HMGB1) mediates inflammatory and immune reactions in nervous system and emerging evidence reveals that HMGB1 plays an essential role in neuroinflammation through receptors such as Toll-like receptors (TLR), receptor for advanced glycation end products (RAGE), C-X-X motif chemokines receptor 4 (CXCR4), and N-methyl-D-aspartate (NMDA) receptor...
2016: Journal of Immunology Research
Sam Man Lee, Mark Hutchinson, David A Saint
Cardiac ischaemic-reperfusion injury (IRI) remains the primary cause of mortality throughout the developed world. Molecular mechanisms underlying IRI are complex and are often interlinked with each other driving a synergistic response. Toll-like receptor 4 (TLR4), an immunosurveillance receptor, is known to enhance tissue injury during IRI by enhancing the inflammatory response. The release of endogenous components during IRI bind onto TLR4 leading to the activation of multiple signalling kinases. Once this event occurs these proteins are defined as danger associated molecular patterns molecules (DAMPs) or alarmins...
September 2016: Clinical and Experimental Pharmacology & Physiology
Qingjie Chen, Xiaofeng Guan, Xiaocong Zuo, Jianglin Wang, Wenjun Yin
High mobility group box 1 (HMGB1) is a nuclear protein that can bind to DNA and act as a co-factor for gene transcription. When released into extracellular fluid, it plays a proinflammatory role by acting as a damage-associated molecular pattern molecule (DAMP) (also known as an alarmin) to initiate innate immune responses by activating multiple cell surface receptors such as the receptor for advanced glycation end-products (RAGE) and toll-like receptors (TLRs), TLR2, TLR4 or TLR9. This proinflammatory role is now considered to be important in the pathogenesis of a wide range of kidney diseases whether they result from hemodynamic changes, renal tubular epithelial cell apoptosis, kidney tissue fibrosis or inflammation...
May 2016: Acta Pharmaceutica Sinica. B
Franco Pandolfi, Simona Altamura, Simona Frosali, Pio Conti
PURPOSE: This review aimed to take stock of the current status of research on damage-associated molecular pattern (DAMP) protein. We discuss the Janus-faced role of DAMP molecules in inflammation, cancer, and tissue repair. The high-mobility group box (HMGB)-1 and adenosine triphosphate proteins are well-known DAMP molecules and have been primarily associated with inflammation. However, as we shall see, recent data have linked these molecules to tissue repair. HMGB1 is associated with cancer-related inflammation...
May 2016: Clinical Therapeutics
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