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Hmgb1 & review

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https://www.readbyqxmd.com/read/27910767/immunostimulatory-effects-of-melphalan-and-usefulness-in-adoptive-cell-therapy-with-antitumor-cd4-t-cells
#1
Michal Kuczma, Zhi-Chun Ding, Gang Zhou
The alkylating agent melphalan is used in the treatment of hematological malignancies, especially multiple myeloma. In the past, the usefulness of melphalan has been solely attributed to its cytotoxicity on fastgrowing cancerous cells. Although the immunomodulatory effects of melphalan were suggested many years ago, only recently has this aspect of melphalan's activity begun to be elucidated at the molecular level. Emerging evidence indicates that melphalan can foster an immunogenic microenvironment by inducing immunogenic cell death (ICD) as characterized by membrane translocation of endoplasmic reticulum protein calreticulin (CRT) and by release of chromatin-binding protein high-mobility group box 1 (HMGB1)...
2016: Critical Reviews in Immunology
https://www.readbyqxmd.com/read/27886851/the-role-of-necroptosis-in-pulmonary-diseases
#2
REVIEW
Kenji Mizumura, Shuichiro Maruoka, Yasuhiro Gon, Augustine M K Choi, Shu Hashimoto
By regulating the cell number and eliminating harmful cells, programmed cell death plays a critical role in development, homeostasis, and disease. While apoptosis is a recognized form of programmed cell death, necrosis was considered a type of uncontrolled cell death induced by extreme physical or chemical stress. However, recent studies have revealed the existence of a genetically programmed and regulated form of necrosis, termed necroptosis. Necroptosis is defined as necrotic cell death that is dependent on receptor-interacting protein kinase 3 (RIPK3)...
November 2016: Respiratory Investigation
https://www.readbyqxmd.com/read/27862491/alarmins-and-central-nervous-system-inflammation-in-hiv-associated-neurological-disorders
#3
M-L Gougeon
In the era of highly active antiretroviral therapy (HAART), HIV-1-associated neurocognitive disorders (HAND) persist in infected individuals with adequate immunological and virological status. Risk factors for cognitive impairment include hepatitis C virus co-infection, host genetic factors predisposing to HAND, the early establishment of the virus in the CNS and its persistence under HAART; thus, the CNS is an important reservoir for HIV. Microglial cells are permissive to HIV-1, and NLRP3 inflammasome-associated genes were found expressed in brains of HIV-1-infected persons, contributing to brain disease...
November 16, 2016: Journal of Internal Medicine
https://www.readbyqxmd.com/read/27836008/high-mobility-group-protein-box1-expression-correlates-with-peritumoral-macrophage-infiltration-and-unfavorable-prognosis-in-patients-with-hepatocellular-carcinoma-and-cirrhosis
#4
Qiang-Bo Zhang, Qing-An Jia, Hong Wang, Chun-Xiao Hu, Dong Sun, Run-De Jiang, Zong-Li Zhang
BACKGROUND: High-mobility group protein box1 (HMGB1) is a pivotal factor in the development and progression of many types of tumor. Its role in hepatocellular carcinoma (HCC), and especially its correlation with intratumoral and peritumoral macrophage infiltration, remains obscure. We analyzed the potential roles and prognostic value of HMGB1 and explored the correlation between HMGB1 and macrophage infiltration in HCC using clinical samples. METHODS: We reviewed clinicopathological and follow-up data on a cohort of 149 patients with HCC complicated with Hepatitis B-related cirrhosis...
November 11, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27819487/the-danger-zone-systematic-review-of-the-role-of-hmgb1-danger-signalling-in-traumatic-brain-injury
#5
Taylor M Parker, Austin Huy Nguyen, Joshua R Rabang, Arun-Angelo Patil, Devendra K Agrawal
BACKGROUND: Traumatic brain injuries (TBI) are associated with complex inflammatory pathways that lead to the development of secondary injuries such as cerebral ischaemia, elevated intracranial pressure and cognitive deficits. The association between intracellular danger signalling involving nuclear chromatin-binding factor, high mobility group box-1 (HMGB1) and inflammatory pathways following TBI has not yet been fully understood. PRIMARY OBJECTIVE: To comprehensively review the available literature regarding the potential diagnostic, prognostic and therapeutic use of HMGB1 in TBI...
November 7, 2016: Brain Injury: [BI]
https://www.readbyqxmd.com/read/27798227/cell-death-mechanisms-in-human-chronic-liver-diseases-a-far-cry-from-clinical-applicability
#6
REVIEW
Guillermo Mazzolini, Jan-Peter Sowa, Ali Canbay
The liver is constantly exposed to a host of injurious stimuli. This results in hepatocellular death mainly by apoptosis and necrosis, but also due to autophagy, necroptosis, pyroptosis and in some cases by an intricately balanced combination thereof. Overwhelming and continuous cell death in the liver leads to inflammation, fibrosis, cirrhosis, and eventually hepatocellular carcinoma. Although data from various disease models may suggest a specific (predominant) cell death mode for different aetiologies, the clinical reality is not as clear cut...
December 1, 2016: Clinical Science (1979-)
https://www.readbyqxmd.com/read/27782807/damps-mamps-and-namps-in-plant-innate-immunity
#7
REVIEW
Hyong Woo Choi, Daniel F Klessig
BACKGROUND: Multicellular organisms have evolved systems/mechanisms to detect various forms of danger, including attack by microbial pathogens and a variety of pests, as well as tissue and cellular damage. Detection via cell-surface receptors activates an ancient and evolutionarily conserved innate immune system. RESULT: Potentially harmful microorganisms are recognized by the presence of molecules or parts of molecules that have structures or chemical patterns unique to microbes and thus are perceived as non-self/foreign...
October 26, 2016: BMC Plant Biology
https://www.readbyqxmd.com/read/27679863/sterile-inflammation-and-pregnancy-complications-a-review
#8
Mathieu Nadeau-Vallee, Dima Obari, Julia Palacios, Marie-Eve Brien, Cyntia Duval, Sylvain Chemtob, Sylvie Girard
Inflammation is central to successful reproduction. In the last decade, important advances have been made in regards to endogenous, and therefore non-infectious, initiators of inflammation which can act through the same receptors as pathogens. These molecules are referred to as damage-associated molecular patterns (DAMPs) and their involvement in reproduction has only recently begun to be unraveled. Even though inflammation is necessary for successful reproduction, untimely activation of inflammatory processes can have devastating impact on pregnancy outcomes...
September 27, 2016: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/27659403/alarmins-firing-arthritis-helpful-diagnostic-tools-and-promising-therapeutic-targets
#9
Miha Lavric, María Auxiliadora Miranda-García, Dirk Holzinger, Dirk Foell, Helmut Wittkowski
Alarmins are endogenous molecules with homeostatic roles that have reached the focus of research in inflammatory arthritis in the last two decades, mostly due to their ability to indicate tissue related damage after active or passive release from injured cells. From HMGB1, S100A8/A9 and S100A12 proteins, over heat-shock proteins (HSPs) and purine metabolites (e.g. uric acid, ATP) to altered matrix proteins and interleukin-33 (IL-33), a number of alarmins have been determined until now as having a role in rheumatoid arthritis, psoriatic and juvenile idiopathic arthritis, as well as spondyloarthritis and gout...
September 19, 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/27630273/paradoxical-role-of-hmgb1-in-pancreatic-cancer-tumor-suppressor-or-tumor-promoter
#10
REVIEW
María José García Cebrián, Monika Bauden, Roland Andersson, Stefan Holdenrieder, Daniel Ansari
Pancreatic cancer has a dismal prognosis and there is an increasing and unmet need to identify better diagnostic and therapeutic targets in order to ameliorate the course of the disease. HMGB1, a nuclear DNA-binding protein that acts as a transcription factor, is currently in the limelight. HMGB1 exhibits a dual role in pancreatic cancer; when intracellular, it acts as an anti-tumor protein stabilizing the genome, whereas extracellular HMGB1 behaves as a pro-tumor protein with cytokine, chemokine and growth factor functions...
September 2016: Anticancer Research
https://www.readbyqxmd.com/read/27612847/receptor-for-advanced-glycation-end-products-rage-in-type-1-diabetes-pathogenesis
#11
REVIEW
Sherman S Leung, Josephine M Forbes, Danielle J Borg
The receptor for advanced glycation end products (RAGE) is a novel protein increasingly studied in the pathogenesis of type 1 diabetes (T1D). RAGE is expressed by several immune cell types, including T cells, antigen-presenting cells, endothelial cells, and the endocrine cells of the pancreatic islets. RAGE binds various ligands including advanced glycation end products (AGEs), high-mobility group box protein 1 (HMGB1), S100 proteins, β-amyloid, β-sheet fibrils, and lipopolysaccharide. AGEs are a particularly interesting ligand because their exogenous introduction into the body can be accelerated by the consumption of AGE-rich processed foods...
October 2016: Current Diabetes Reports
https://www.readbyqxmd.com/read/27563308/ppar-ligands-function-as-suppressors-that-target-biological-actions-of-hmgb1
#12
REVIEW
Shibo Ying, Xiang Xiao, Tianhui Chen, Jianlin Lou
High mobility group box 1 (HMGB1), which has become one of the most intriguing molecules in inflammatory disorders and cancers and with which ligand-activated peroxisome proliferator-activated receptors (PPARs) are highly associated, is considered as a therapeutic target. Of particular interest is the fact that certain PPAR ligands have demonstrated their potent anti-inflammatory activities and potential anticancer effects. In this review article we summarize recent experimental evidence that PPAR ligands function as suppressors that target biological actions of HMGB1, including intracellular expression, receptor signaling cascades, and extracellular secretion of HMGB1 in cell lines and/or animal models...
2016: PPAR Research
https://www.readbyqxmd.com/read/27558820/immunogenic-apoptotic-cell-death-and-anticancer-immunity
#13
Peter Vandenabeele, Katrien Vandecasteele, Claus Bachert, Olga Krysko, Dmitri V Krysko
For many years it has been thought that apoptotic cells rapidly cleared by phagocytic cells do not trigger an immune response but rather have anti-inflammatory properties. However, accumulating experimental data indicate that certain anticancer therapies can induce an immunogenic form of apoptosis associated with the emission of damage-associated molecular patterns (DAMPs), which function as adjuvants to activate host antitumor immune responses. In this review, we will first discuss recent advances and the significance of danger signaling pathways involved in the emission of DAMPs, including calreticulin, ATP, and HMGB1...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27557670/from-genesis-to-revelation-the-role-of-inflammatory-mediators-in-chronic-respiratory-diseases-and-their-control-by-nucleic-acid-based-drugs
#14
Sante Di Gioia, Carla Sardo, Stefano Castellani, Barbara Porsio, Giuliana Belgiovine, Annalucia Carbone, Gaetano Giammona, Gennara Cavallaro, Massimo Conese
Asthma, chronic obstructive pulmonary disease, cystic fibrosis, and idiopathic pulmonary fibrosis, are among the most common chronic diseases and their prevalence is increasing. Each of these diseases is characterized by the secretion of cytokines and pro-inflammatory molecules which are thought to play a critical role in their pathogenesis. Moreover, immune cells, particularly neutrophils, macrophages and dendritic cells as well structural cells such as epithelial and airway smooth muscle cells are also involved in the pathogenic cycle of these diseases...
August 24, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/27540303/the-association-of-hmgb1-expression-with-clinicopathological-significance-and-prognosis-in-asian-patients-with-colorectal-carcinoma-a-meta-analysis-and-literature-review
#15
Xiaoli Zhang, Jinming Yu, Minghuan Li, Hui Zhu, Xindong Sun, Li Kong
BACKGROUND: The association of high mobility group box 1 (HMGB1) expression with clinicopathological significance and prognosis in Asian patients with colorectal carcinoma (CRC) remains controversial. The purpose of this study was to conduct a meta-analysis and literature review to identify the role of HMGB1 in the development and prognosis of CRC in Asians. METHODS: All eligible studies regarding the association between HMGB1 expression in tissue with clinicopathological significance and prognosis in Asian patients with CRC published up to January 2015 were identified by searching PubMed, Web of Science, Chinese National Knowledge Infrastructure, and WanFang database...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27501713/therapeutic-targeting-of-hmgb1-in-stroke
#16
Xiaodi Tian, Zhong Wang, Gang Chen
High mobility group box-1 (HMGB1), a highly conserved nonhistone nuclear protein, is widely expressed in most eukaryotic cells including neural cells. Nuclear HMGB1 stabilize nucleosome formation and facilitates gene transcription. HMGB1 can be passively released from necrotic cells or actively secreted from stimulated immune cells. Extracellular HMGB1 interacts with receptors, including the receptor for advanced glycation endproducts (RAGEs), Toll-like receptor 2 (TLR2) and TLR4. After brain injury, HMGB1 is released early from neural cells and contribute to the early stages of the inflammatory response...
August 8, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/27494867/endoplasmic-reticulum-stress-induces-secretion-of-high-mobility-group-proteins-and-is-associated-with-tumor-infiltrating-lymphocytes-in-triple-negative-breast-cancer
#17
In Ah Park, Sun-Hee Heo, In Hye Song, Young-Ae Kim, Hye Seon Park, Won Seon Bang, Suk Young Park, Jeong-Hyon Jo, Hee Jin Lee, Gyungyub Gong
BACKGROUND: Although the prognostic and predictive significance of tumor-infiltrating lymphocytes (TILs) in triple-negative breast cancer (TNBC) have been shown, the cause of the TIL influx is unclear. Here, we investigated whether extracellular secretion of HMGN1 is associated with TIL influx, as well as increased endoplasmic reticulum stress (ERS), in human TNBC. METHODS: We reviewed the slides of 767 patients with TNBC and evaluated the TIL levels. We also assessed the expression of HMGs and several ERS-associated molecules using immunohistochemical staining...
August 2, 2016: Oncotarget
https://www.readbyqxmd.com/read/27434574/-role-of-alarmins-high-mobility-group-protein-b1-in-sepsis
#18
Jiaxin Wei, Ying Zhang, Xiaoyuan Ma, Lixing Tian, Huaping Liang
High mobility group protein B1 (HMGB1) is the most representative substance in the alarmins family, it is actively or passively release to extracellular by the activation of monocyte/macrophage and the dead cells, and then it stimulates the production of a variety of inflammatory mediators, and increases the organism's inflammatory response through relevant receptors signaling pathways. In recent years, its concentration can reflect the severity of inflammation and injury and was related to the prognosis, HMGB1 has won more and more attention in the development of sepsis...
August 2016: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/27418836/association-between-an-elevated-level-of-hmgb1-and-non-small-cell-lung-cancer-a-meta-analysis-and-literature-review
#19
Quansong Xia, Juan Xu, Huoying Chen, Yanzhang Gao, Feili Gong, Liya Hu, Li Yang
BACKGROUND: HMGB1 has been overexpressed in the tissues or serum of patients with non-small-cell lung cancer (NSCLC) in several studies. However, the results remain inconsistent. OBJECTIVE: The aim of this study was to perform a meta-analysis to investigate the relationship between elevated level of HMGB1 and NSCLC. METHODS: Associated studies were included, and the pooled risk difference and mean difference (MD) together with 95% confidence interval (CI) were calculated...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27391431/hmgb1-overexpression-as-a-prognostic-factor-for-survival-in-cancer-a-meta-analysis-and-systematic-review
#20
Tengyun Wu, Wei Zhang, Geliang Yang, Huijun Li, Qi Chen, Ruixiang Song, Lin Zhao
As there are millions of cancer deaths every year, it is of great value to identify applicable prognostic biomarkers. As an important alarm, the prognostic role of high mobility group box 1 (HMGB1) in cancer remains controversial. We aim to assess the association of HMGB1 expression with prognosis in cancer patients. Systematic literature searches of PubMed, Embase and Web of Science databases were performed for eligible studies of HMGB1 as prognostic factor in cancer. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated to evaluate the influence of HMGB1 expression on overall survival (OS) and progression-free survival (PFS) in cancer patients...
July 6, 2016: Oncotarget
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