Anna Lewińska, Adrian Radoń, Kacper Gil, Dominika Błoniarz, Agnieszka Ciuraszkiewicz, Jerzy Kubacki, Mariola Kądziołka-Gaweł, Dariusz Łukowiec, Piotr Gębara, Agnieszka Krogul-Sobczak, Piotr Piotrowski, Oktawia Fijałkowska, Sylwia Wybraniec, Tomasz Szmatoła, Aleksandra Kolano-Burian, Maciej Wnuk
The surface modification of magnetite nanoparticles (Fe3 O4 NPs) is a promising approach to obtaining biocompatible and multifunctional nanoplatforms with numerous applications in biomedicine, for example, to fight cancer. However, little is known about the effects of Fe3 O4 NP-associated reductive stress against cancer cells, especially against chemotherapy-induced drug-resistant senescent cancer cells. In the present study, Fe3 O4 NPs in situ coated by dextran (Fe3 O4 @Dex) and glucosamine-based amorphous carbon coating (Fe3 O4 @aC) with potent reductive activity were characterized and tested against drug-induced senescent breast cancer cells (Hs 578T, BT-20, MDA-MB-468, and MDA-MB-175-VII cells)...
March 14, 2024: ACS Applied Materials & Interfaces