keyword
https://read.qxmd.com/read/38493478/histone-h3-1-is-a-chromatin-embedded-redox-sensor-triggered-by-tumor-cells-developing-adaptive-phenotypic-plasticity-and-multidrug-resistance
#1
JOURNAL ARTICLE
Flavio R Palma, Diego R Coelho, Kirthi Pulakanti, Marcelo J Sakiyama, Yunping Huang, Fernando T Ogata, Jeanne M Danes, Alison Meyer, Cristina M Furdui, Douglas R Spitz, Ana P Gomes, Benjamin N Gantner, Sridhar Rao, Vadim Backman, Marcelo G Bonini
Chromatin structure is regulated through posttranslational modifications of histone variants that modulate transcription. Although highly homologous, histone variants display unique amino acid sequences associated with specific functions. Abnormal incorporation of histone variants contributes to cancer initiation, therapy resistance, and metastasis. This study reports that, among its biologic functions, histone H3.1 serves as a chromatin redox sensor that is engaged by mitochondrial H2 O2 . In breast cancer cells, the oxidation of H3...
March 15, 2024: Cell Reports
https://read.qxmd.com/read/38492996/assessment-of-postmastectomy-radiation-therapy-receipt-by-age-and-association-with-outcomes-in-women-with-breast-cancer
#2
JOURNAL ARTICLE
Carolina E Fasola, Elaina Graham, Wei Sha, Courtney R Schepel, Sally J Trufan, Anna Hecksher, Richard L White, Lejla Hadzikadic-Gusic
PURPOSE: Postmastectomy radiation therapy (PMRT) reduces locoregional recurrence (LRR) and improves overall survival (OS) in patients with breast cancer. Young age has been recognized as a risk factor for LRR. The primary objective of this study was to determine if recommendations for PMRT differed among patients younger than 50 years as compared to women aged 50 years or older. METHODS: We reviewed medical records of patients with breast cancer who underwent mastectomy with or without PMRT from 2010 through 2018...
February 28, 2024: Clinical Breast Cancer
https://read.qxmd.com/read/38492995/comparison-of-pd-l1-22c3-expression-in-paired-primary-and-metastatic-breast-carcinoma
#3
JOURNAL ARTICLE
Xiao Huang, Sarah A Anderson, Gene P Siegal, Shi Wei, Shanrun Liu, Jingyun Yang, Puentes Roisin, J Taylor Pickens, Lei Huo, Aysegul A Sahin, Carlos Prieto Granada, Shuojun Chen
INTRODUCTION: PD-L1 immunohistochemistry (IHC) is being used as a predictive marker of the benefit derived from immunotherapy in several cancer types, including breast cancer. However, the insight gleaned of the prognostic and predictive value of PD-L1 status and its correlation with molecular characteristics during breast cancer progression remains limited. METHODS: We performed an PD-L1 (22C3) assay in pre-treatment primary and metastatic tumor sections from 33 patients with breast carcinoma, matched for post neoadjuvant chemotherapy (p-NACT)...
February 16, 2024: Clinical Breast Cancer
https://read.qxmd.com/read/38492860/active-targeting-tumor-therapy-using-host-guest-drug-delivery-system-based-on-biotin-functionalized-azocalix-4-arene
#4
JOURNAL ARTICLE
Meng-Meng Chen, Xingchen Tang, Juan-Juan Li, Fang-Yuan Chen, Ze-Tao Jiang, Rong Fu, Hua-Bin Li, Xin-Yue Hu, Wen-Chao Geng, Dong-Sheng Guo
Host-guest drug delivery systems (HGDDSs) provided a facile method for incorporating biomedical functions, including efficient drug-loading, passive targeting, and controlled drug release. However, developing HGDDSs with active targeting is hindered by the difficult functionalization of popular macrocycles. Herein, we report an active targeting HGDDS based on biotin-modified sulfonated azocalix[4]arene (Biotin-SAC4A) to efficiently deliver drug into cancer cells for improving anti-tumor effect. Biotin-SAC4A was synthesized by amide condensation and azo coupling...
March 14, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38492276/platinum-chemotherapy-for-early-triple-negative-breast-cancer
#5
REVIEW
Sofia Re Mason, Melina L Willson, Sam J Egger, Jane Beith, Rachel F Dear, Annabel Goodwin
BACKGROUND: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer associated with shorter survival and a higher likelihood of recurrence. In early TNBC, platinum chemotherapy has been shown to improve pathological complete response (pCR); however, its effect on long-term survival outcomes has not been fully elucidated. METHODS: Randomised controlled trials examining neoadjuvant or adjuvant platinum chemotherapy for early TNBC were included...
March 12, 2024: Breast: Official Journal of the European Society of Mastology
https://read.qxmd.com/read/38492259/oncologic-safety-of-breast-conserving-surgery-after-neoadjuvant-chemotherapy-in-patients-with-multiple-ipsilateral-breast-cancer-a-retrospective-multi-institutional-cohort-study
#6
JOURNAL ARTICLE
Élise Di Lena, Stephanie M Wong, Ericka Iny, Sarah Mashal, Mark Basik, Jean-François Boileau, Karyne Martel, Miranda Addie Bassel, Sarkis Meterissian, Ipshita Prakash
INTRODUCTION: The recent ACOSOG Z11102 trial demonstrated low recurrence rates with breast conserving surgery (BCS) in women with multiple ipsilateral breast cancers (MIBC). Questions remain regarding the oncologic safety of BCS in women with MIBC receiving neoadjuvant chemotherapy (NAC). METHODS: We conducted a retrospective cohort study of adult patients who underwent BCS following NAC for stage I-III breast cancer from 2012 to 2021 at two academic centers...
March 12, 2024: European Journal of Surgical Oncology
https://read.qxmd.com/read/38492205/liquid-biopsy-for-breast-cancer-and-other-solid-tumors-a-review-of-recent-advances
#7
JOURNAL ARTICLE
Hirofumi Ohmura, Fumiyasu Hanamura, Yuta Okumura, Yuki Ando, Takaaki Masuda, Koshi Mimori, Koichi Akashi, Eishi Baba
Liquid biopsy using circulating tumor DNA (ctDNA) has been reported to be less invasive and effective for comprehensive genetic analysis of heterogeneous solid tumors, including decision-making for therapeutic strategies, predicting recurrence, and detecting genetic factors related to treatment resistance in various types of cancers. Breast cancer, colorectal cancer, and lung cancer are among the most prevalent malignancies worldwide, and clinical studies of liquid biopsy for these cancers are ongoing. Liquid biopsy has been used as a companion diagnostic tool in clinical settings, and research findings have accumulated, especially in cases of colorectal cancer after curative resection and non-small cell lung cancer (NSCLC) after curative chemoradiotherapy, in which ctDNA detection helps predict eligibility for adjuvant chemotherapy...
March 16, 2024: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://read.qxmd.com/read/38491203/a-novel-approach-to-computing-preference-estimates-for-different-treatment-pathways-an-application-in-oncology
#8
JOURNAL ARTICLE
Kathleen Beusterien, Oliver Will, Emuella Flood, Susan McCutcheon, deMauri S Mackie, Stella Mokiou
BACKGROUND: Patients with cancer may progress through multiple treatments with differing adverse effect profiles. Moreover, pathways may be fixed or flexible in allowing for escalation or de-escalation of treatment depending on interim outcomes. We sought to develop a methodology capable of estimating preferences for the entirety of a pathway involving a sequence of different treatments. METHODS: Patients with early breast cancer completed an online discrete choice experiment to assess preferences for eight key early breast cancer attributes...
March 15, 2024: Patient
https://read.qxmd.com/read/38491128/evaluating-persistent-t1-weighted-lesions-without-concurrent-abnormal-enhancement-on-breast-mri-in-neoadjuvant-chemotherapy-patients-implications-for-complete-pathological-response
#9
JOURNAL ARTICLE
Shahine Goulam-Houssein, Xiang Y Ye, Rachel Fleming, Frederick Au, Supriya Kulkarni, Sandeep Ghai, Yoav Amitai, Michael Reedijk, Vivianne Freitas
OBJECTIVE: This study aims to determine whether persistent T1-weighted lesions signify a complete pathological response (pCR) in breast cancer patients treated with neoadjuvant chemotherapy and surgery, and to evaluate their correlation with imaging responses on MRI. MATERIALS AND METHODS: A retrospective review was conducted on data from breast cancer patients treated between January 2011 and December 2018. Patients who underwent breast MRI and pre- and post-neoadjuvant chemotherapy followed by surgery were included...
March 16, 2024: European Radiology
https://read.qxmd.com/read/38490656/adjuvant-chemotherapy-and-survival-outcomes-in-older-women-with-hr-her2-breast-cancer-a-propensity-score-matched-retrospective-cohort-study-using-the-seer-database
#10
JOURNAL ARTICLE
Xindi Ma, Shang Wu, Xiangmei Zhang, Nannan Chen, Chenhui Yang, Chao Yang, Miao Cao, Kaiye Du, Yunjiang Liu
OBJECTIVES: This study aimed to investigate the impact of adjuvant chemotherapy (ACT) on survival outcomes in older women with hormone receptor-positive and human epidermal growth factor receptor 2-negative (HR+/HER2-) breast cancer (BC). DESIGN: A retrospective cohort study using data from the Surveillance, Epidemiology, and End Results database, which contains publicly available information from US cancer registries. SETTING AND PARTICIPANTS: The study included 45 762 older patients with BC aged over 65 years diagnosed between 2010 and 2015...
March 15, 2024: BMJ Open
https://read.qxmd.com/read/38489717/construction-and-validation-of-nomogram-for-the-cancer-specific-mortality-for-her2-positive-breast-cancer-patients
#11
JOURNAL ARTICLE
Nan Wu
The cancer-specific mortality (CSM) of patients with human epidermal growth factor receptor 2 positive (HER2+) breast cancer remains dismal and varies widely from person to person. Therefore, we aim to construct a nomogram to predict CSM in HER2+ breast cancer using data from the surveillance, epidemiology, and end results (SEER) database. The clinicopathological data of patients diagnosed with HER2+ breast cancer from 2000 to 2019 were selected from the SEER database. Independent prognostic factors for CSM of patients were identified by competing risk model...
March 15, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38489305/cost-effectiveness-of-one-year-adjuvant-trastuzumab-therapy-in-treatment-for-early-stage-breast-cancer-patients-with-her2-in-vietnam
#12
JOURNAL ARTICLE
Anh Quynh Nguyen, Oanh Thi Mai Tran, Phuong Khanh Nguyen, Ha Thu Nguyen
BACKGROUND: In Vietnam, trastuzumab is included in social health insurance's benefits package with a reimbursement rate of 60%, but policymakers have been concerned about its cost-effectiveness. The research aims to evaluate the cost-effectiveness of one-year adjuvant trastuzumab therapy for early-stage breast cancer patients with human epidermal growth receptor 2 (HER2+) from a societal perspective. METHOD: A Markov model was developed and validated to estimate the lifetime cost and effectiveness (using life year and quality-adjusted life year) of one-year adjuvant trastuzumab therapy compared to chemotherapy (using paclitaxel) alone...
2024: PloS One
https://read.qxmd.com/read/38489166/use-of-axillary-ultrasound-to-guide-breast-cancer-management-in-the-genomic-assay-era
#13
JOURNAL ARTICLE
Geok Hoon Lim, John Carson Allen, Yien Sien Lee, Sze Yiun Teo, Li Ching Lau, Thida Win, Lester Chee Hao Leong
INTRODUCTION: Chemotherapy is conventionally offered to non-stage IV breast cancer patients with metastatic nodes. However, the RxPONDER trial showed that chemotherapy can be omitted in selected patients with 1-3 metastatic nodes if the 21-gene assay recurrence score is ≤25. We aimed to investigate if axillary ultrasound can identify this group of patients with limited nodal burden so that they can undergo upfront surgery followed by gene assay testing, to potentially avoid chemotherapy...
2024: Breast Disease
https://read.qxmd.com/read/38489021/a-systematic-review-of-health-related-quality-of-life-in-women-with-her2-positive-metastatic-breast-cancer-treated-with-trastuzumab
#14
Sudewi Mukaromah Khoirunnisa, Fithria Dyah Ayu Suryanegara, Lisa Aniek de Jong, Didik Setiawan, Maarten Jacobus Postma
BACKGROUND: Many trials of human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer treatment with trastuzumab have provided evidence of improved clinical outcomes. This systematic review examined how a regimen that includes trastuzumab affects patients' health-related quality of life (HRQoL) during and after treatment. METHODS: A systematic search for articles published up to February 2023 without restrictions of language or publication year was performed using the Pubmed, Embase, and Scopus databases...
March 15, 2024: PharmacoEconomics Open
https://read.qxmd.com/read/38487087/exploring-the-vast-potentials-and-probable-limitations-of-novel-and-nanostructured-implantable-drug-delivery-systems-for-cancer-treatment
#15
REVIEW
Maryam Ebrahimnia, Sonia Alavi, Hamed Vaezi, Mahdieh Karamat Iradmousa, Azadeh Haeri
Conventional cancer chemotherapy regimens, albeit successful to some extent, suffer from some significant drawbacks, such as high-dose requirements, limited bioavailability, low therapeutic indices, emergence of multiple drug resistance, off-target distribution, and adverse effects. The main goal of developing implantable drug delivery systems (IDDS) is to address these challenges and maintain anti-cancer drugs directly at the intended sites of therapeutic action while minimizing inevitable side effects. IDDS possess numerous advantages over conventional drug delivery, including controlled drug release patterns, one-time drug administration, as well as loading and stabilizing poorly water-soluble chemotherapy drugs...
2024: EXCLI Journal
https://read.qxmd.com/read/38486987/phase-separation-of-nur77-mediates-xs561-induced-apoptosis-by-promoting-the-formation-of-nur77-bcl-2-condensates
#16
JOURNAL ARTICLE
Xiaohui Chen, Meichun Gao, Yongzhen Xia, Xin Wang, Jingbo Qin, Hongying He, Weirong Liu, Xiaowei Zhang, Shuangzhou Peng, Zhiping Zeng, Ying Su, Xiaokun Zhang
The orphan nuclear receptor Nur77 is a critical regulator of the survival and death of tumor cells. The pro-death effect of Nur77 can be regulated by its interaction with Bcl-2, resulting in conversion of Bcl-2 from a survival to killer. As Bcl-2 is overexpressed in various cancers preventing them from apoptosis and promoting their resistance to chemotherapy, targeting the apoptotic pathway of Nur77/Bcl-2 may lead to new cancer therapeutics. Here, we report our identification of XS561 as a novel Nur77 ligand that induces apoptosis of tumor cells by activating the Nur77/Bcl-2 pathway...
March 2024: Acta Pharmaceutica Sinica. B
https://read.qxmd.com/read/38485557/stromal-type-i-collagen-in-breast-cancer-correlation-to-prognostic-biomarkers-and-prediction-of-chemotherapy-response
#17
JOURNAL ARTICLE
Malin Jansson, Jessica Lindberg, Gunilla Rask, Johan Svensson, Ola Billing, Anoosheh Nazemroaya, Anette Berglund, Fredrik Wärnberg, Malin Sund
INTRODUCTION: Fibrillar collagens accumulate in the breast cancer stroma and appear as poorly defined spiculated masses in mammography imaging. The prognostic value of tissue type I collagen remains elusive in treatment-naïve and chemotherapy-treated breast cancer patients. Here, type I collagen mRNA and protein expression were analysed in 2 large independent breast cancer cohorts. Levels were related to clinicopathological parameters, prognostic biomarkers, and outcome. METHOD: COL1A1 mRNA expression was analysed in 2509 patients with breast cancer obtained from the cBioPortal database...
February 21, 2024: Clinical Breast Cancer
https://read.qxmd.com/read/38484493/evaluation-of-traditional-targeted-axillary-dissection-eligibility-criteria-for-node-positive-breast-cancer-after-neoadjuvant-chemotherapy-in-a-prospective-multicenter-registry
#18
JOURNAL ARTICLE
Catherine Loveland-Jones, John Gaughan, Abigail Caudle, Brittany Murphy, Laila Samiian, Stephanie Byrum, Kristen Brill, Pauline Germaine, Xinmin Zhang, Kay Yoon-Flannery, Teralyn Carter, Adrian Lopez, Ryan Gruner, Michele Fantazzio, Henry Kuerer
INTRODUCTION: Targeted axillary dissection (TAD) is performed after neoadjuvant systemic therapy (NST) to decrease the rate of non-therapeutic axillary dissection (ALND) for patients with node-positive breast cancer. In order to ensure the oncologic safety of TAD, eligibility criteria resulting in a low false negative rate (FNR) have been proposed. The purpose of this study was to evaluate the utility of the traditional criteria. METHODS: Data was collected from a prospective multicenter registry...
March 3, 2024: European Journal of Surgical Oncology
https://read.qxmd.com/read/38483821/carbon-coated-iron-oxide-nanoparticles-promote-reductive-stress-mediated-cytotoxic-autophagy-in-drug-induced-senescent-breast-cancer-cells
#19
JOURNAL ARTICLE
Anna Lewińska, Adrian Radoń, Kacper Gil, Dominika Błoniarz, Agnieszka Ciuraszkiewicz, Jerzy Kubacki, Mariola Kądziołka-Gaweł, Dariusz Łukowiec, Piotr Gębara, Agnieszka Krogul-Sobczak, Piotr Piotrowski, Oktawia Fijałkowska, Sylwia Wybraniec, Tomasz Szmatoła, Aleksandra Kolano-Burian, Maciej Wnuk
The surface modification of magnetite nanoparticles (Fe3 O4 NPs) is a promising approach to obtaining biocompatible and multifunctional nanoplatforms with numerous applications in biomedicine, for example, to fight cancer. However, little is known about the effects of Fe3 O4 NP-associated reductive stress against cancer cells, especially against chemotherapy-induced drug-resistant senescent cancer cells. In the present study, Fe3 O4 NPs in situ coated by dextran (Fe3 O4 @Dex) and glucosamine-based amorphous carbon coating (Fe3 O4 @aC) with potent reductive activity were characterized and tested against drug-induced senescent breast cancer cells (Hs 578T, BT-20, MDA-MB-468, and MDA-MB-175-VII cells)...
March 14, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38482672/changes-in-breast-cancer-grade-from-biopsy-to-excision-following-surgery-or-primary-chemotherapy
#20
JOURNAL ARTICLE
Ádám Ferenczi, Gábor Cserni
OBJECTIVE: To compare histological grade (G) of breast cancer and its components (scores for tubule formation - T, nuclear pleomorphism - P and mitotic counts - M) in core needle biopsies (CNBs) and surgical excision specimens (EXC) in patients treated with primary surgery (CHIR) or primary chemotherapy (PST). METHODS: Grade of matched pairs of carcinomas in CNB and EXC was assessed according to the Nottingham grading system. RESULTS: PST cases tended to have higher pretreatment G...
February 2024: Pathologica
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