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esophageal cancer chemotherapy

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https://www.readbyqxmd.com/read/29467557/esophageal-metastasis-of-stem-cell-subtype-hepatocholangiocarcinoma-rare-presentation-of-a-rare-tumor
#1
Maëva Salimon, Nicolas Chapelle, Tamara Matysiak-Budnik, Jean-François Mosnier, Eric Frampas, Yann Touchefeu
Hepatocholangiocarcinoma (cHCC-ICC) is a rare primary hepatic tumor defined by the presence of histological features of both hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). Its prevalence ranges from 1%-5% of all primary liver cancers. We report the case of a 55-year-old cirrhotic male patient admitted to our university hospital for dysphagia, revealing a 10 cm lower-third esophageal metastasis of an unresectable cHCC-ICC with stem-cell features. Computed tomography and abdominal magnetic resonance imaging scans revealed multiple hepatic lesions combining features of both HCC and ICC, associated with synchronous bone metastasis...
February 21, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29459017/poor-performance-in-incremental-shuttle-walk-and-cardiopulmonary-exercise-testing-predicts-poor-overall-survival-for-patients-undergoing-esophago-gastric-resection
#2
Jessica Whibley, Christopher J Peters, Laura J Halliday, Asif M Chaudry, William H Allum
INTRODUCTION: Esophageal and gastric cancer have a poor prognosis and surgical intervention is associated with considerable morbidity, highlighting the need for careful preoperative assessment. The Incremental Shuttle Walk Test (ISWT) and Cardiopulmonary exercise testing (CPET) can assess preoperative fitness. This study aims to investigate their correlation with both postoperative respiratory complications and overall survival. PATIENTS AND METHODS: Patients were identified who underwent esophageal or gastric resections for cancer between 2010 and 2014 and had ISWT and/or CPET assessments...
February 6, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29456850/-18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-for-the-prediction-of-survival-in-patients-with-advanced-esophageal-cancer-who-have-undergone-neoadjuvant-chemotherapy
#3
Masahiko Yano, Hiroshi Miyata, Keijiro Sugimura, Masaaki Motoori, Takeshi Omori, Yoshiyuki Fujiwara, Norikatsu Miyoshi, Masayoshi Yasui, Masayuki Ohue, Hirofumi Akita, Akira Tomokuni, Hidenori Takahashi, Shogo Kobayashi, Masato Sakon
Neoadjuvant chemotherapy (NAC) is a promising treatment strategy for advanced esophageal cancer. However, measures of NAC response assessment and prognostic prediction have not yet been established. The aim of this study was to evaluate the usefulness of combined18 F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT). A total of 77 patients with stage IB-IV esophageal cancer who were treated with NAC followed by curative resection were retrospectively analyzed. PET/CT was performed before and after NAC and 56 patients were clinical responders...
March 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29444281/surgical-management-of-esophageal-sarcoma-a-multicenter-european-experience
#4
D Mege, L Depypere, G Piessen, A E Slaman, B P L Wijnhoven, A Hölscher, M Nilsson, M I van Berge Henegouwen, J J B van Lanschot, W Schroeder, P A Thomas, P Nafteux, X B D'Journo
Esophageal sarcomas are rare and evidence in literature is scarce making their management difficult. The objective is to report surgical and oncological outcomes of esophageal sarcoma in a large multicenter European cohort. This is a retrospective multicenter study including all patients who underwent en-bloc esophagectomy for esophageal sarcoma in seven European tertiary referral centers between 1987 and 2016. The main outcomes and measures are pathological results, early and long-term outcomes. Among 10,936 esophageal resections for cancer, 21 (0...
February 9, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29441562/neoadjuvant-treatments-for-locally-advanced-resectable-esophageal-cancer-a-network-meta-analysis
#5
Kelvin K W Chan, Ronak Saluja, Keemo Delos Santos, Kelly Lien, Keya Shah, Gemma Cramarossa, Xiaofu Zhu, Rebecca K S Wong
The relative survival benefits and post-operative mortality among the different types of neoadjuvant treatments (such as chemotherapy only, radiotherapy only or chemoradiotherapy) for esophageal cancer patients are not well established. To evaluate the relative efficacy and safety of neoadjuvant therapies in resectable esophageal cancer, a Bayesian network meta-analysis was performed. MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials were searched for publications up to May 2016. ASCO and ASTRO annual meeting abstracts were also searched up to the 2015 conferences...
February 14, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29435872/a-phase-ii-trial-of-concurrent-chemoradiotherapy-with-weekly-paclitaxel-and-carboplatin-in-advanced-oesophageal-carcinoma
#6
Kuai-Le Zhao, Yi Xia, Yun-Hai Li, Yun Chen, Qi Liu, Jun-Hua Zhang, Jia-Ying Deng, Ta-Shan Ai, Han-Ting Zhu, Harun Badakhshi
BACKGROUND: This study was performed to assess the efficacy and feasibility of definitive chemoradiotherapy consisting of weekly doses of combined paclitaxel and carboplatin concurrent with radiation therapy, followed by 2 cycles of consolidation chemotherapy for advanced esophageal carcinoma. METHODS: Eligibility criteria included local, advanced, newly diagnosed and postoperative local regional lymph node metastasis; Eastern Cooperative Oncology Group (ECOG) score ≤ 2; and adequate organ function...
February 12, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29429533/the-effect-of-chemotherapy-on-nutritional-status-and-weakness-in-geriatric-gastrointestinal-system-cancer-patients
#7
Derya Hopanci Bicakli, Ahmet Ozveren, Ruchan Uslu, Reci Meseri Dalak, Ruksan Cehreli, Mehmet Uyar, Bulent Karabulut, Fehmi Akcicek
OBJECTIVES: Malnutrition is common in patients with geriatric gastrointestinal system (GIS) cancer. This study aimed to evaluate patients with geriatric GIS cancer in terms of nutritional status and weakness and determine the changes caused by chemotherapy (CT). METHODS: Patients with geriatric GIS cancer who received CT were included in the study. Their nutritional status was assessed with the Mini Nutritional Assessment, and weakness was assessed with the handgrip strength/body mass index ratio...
March 2018: Nutrition
https://www.readbyqxmd.com/read/29417326/role-of-esophageal-metal-stents-placement-and-combination-therapy-in-inoperable-esophageal-carcinoma-a-systematic-review-and-meta-analysis
#8
Andrew Lai, Seth Lipka, Ambuj Kumar, Sajiv Sethi, David Bromberg, Nanxing Li, Huafeng Shen, Lilia Stefaniwsky, Patrick Brady
INTRODUCTION: More than 50% of patients with esophageal cancer already have inoperable disease at the time of diagnosis. Controversy surrounds the outcomes of patients with advanced esophageal cancer who receive palliative care by either stent alone or stent plus an additional modality. We set out to perform a systematic review and meta-analysis of studies assessing the use of metal stents as treatment options for symptomatic improvement, survival, and adverse events. METHODS: We searched Embase, MEDLINE, and the Cochrane Central Register of Controlled Trials (CENTRAL) from inception until January 14, 2016, as well as other databases for randomized controlled trials (RCTs) comparing esophageal stent versus either esophageal stent plus brachytherapy, radiotherapy, or chemotherapy...
February 8, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29416661/gli-is-activated-and-promotes-epithelial-mesenchymal-transition-in-human-esophageal-adenocarcinoma
#9
Lei Wang, Joy Q Jin, Yong Zhou, Ziqiang Tian, David M Jablons, Biao He
Esophageal adenocarcinoma (EAC) accounts for the most esophageal cancer cases in the US, and is notoriously aggressive. This study examines the role of Sonic Hedgehog (SHh)/Gli signaling in the regulation of epithelial-mesenchymal transition (EMT), a process tied to invasion and metastasis, in EAC. Gli/EMT protein expression levels were examined by western blot in paired EAC patient tissues (n = 24) and cell lines (OE19, OE33). Functional analyses were performed (siRNA, treatment with Gli-inhibitor, AKT-inhibitor, and N-Shh recombinant proteins) to investigate SHh/Gli signaling and EMT, cell cycle, and prognostic markers in EAC cell lines...
January 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29410067/single-cell-transcriptome-analyses-reveal-molecular-signals-to-intrinsic-and-acquired-paclitaxel-resistance-in-esophageal-squamous-cancer-cells
#10
Hongjin Wu, Sean Chen, Charles Wang, Juehua Yu, Ying Li, Xiao-Yan Zhang, Ling Yang, Hongfang Zhang, Qiang Hou, Mingfeng Jiang, F Charles Brunicardi, Shixiu Wu
Paclitaxel is widely used in the combination chemotherapy for many cancers including esophageal squamous cell carcinoma (ESCC). However, the paclitaxel resistance occurs frequently in treating ESCC and the mechanism is not fully understood yet. The heterogeneity of gene expression within the drug-resistant cancer cells may be one of the major factors contributing to its resistance. In the present study, we successfully induced paclitaxel resistance in ESCC cell line KYSE-30 through low dose and long-term treatment of paclitaxel...
January 30, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29409462/the-fregat-biobank-a-clinico-biological-database-dedicated-to-esophageal-and-gastric-cancers
#11
Christophe Mariette, Florence Renaud, Guillaume Piessen, Patrick Gele, Marie-Christine Copin, Emmanuelle Leteurtre, Christine Delaeter, Malek Dib, Stéphanie Clisant, Valentin Harter, Franck Bonnetain, Alain Duhamel, Véronique Christophe, Antoine Adenis
BACKGROUND: While the incidence of esophageal and gastric cancers is increasing, the prognosis of these cancers remains bleak. Endoscopy and surgery are the standard treatments for localized tumors, but multimodal treatments, associated chemotherapy, targeted therapies, immunotherapy, radiotherapy, and surgery are needed for the vast majority of patients who present with locally advanced or metastatic disease at diagnosis. Although survival has improved, most patients still present with advanced disease at diagnosis...
February 6, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29398577/cell-death-inflammation-tumor-burden-and-proliferation-blood-biomarkers-predict-lung-cancer-radiotherapy-response-and-correlate-with-tumor-volume-and-proliferation-imaging
#12
Ahmed Salem, Hitesh Mistry, Alison Backen, Clare Hodgson, Pek Koh, Emma Dean, Lynsey Priest, Kate Haslett, Ioannis Trigonis, Alan Jackson, Marie-Claude Asselin, Caroline Dive, Andrew Renehan, Corinne Faivre-Finn, Fiona Blackhall
INTRODUCTION: There is an unmet need to develop noninvasive biomarkers to stratify patients in drug-radiotherapy trials. In this pilot study we investigated lung cancer radiotherapy response and toxicity blood biomarkers and correlated findings with tumor volume and proliferation imaging. PATIENTS AND METHODS: Blood samples were collected before and during (day 21) radiotherapy. Twenty-six cell-death, hypoxia, angiogenesis, inflammation, proliferation, invasion, and tumor-burden biomarkers were evaluated...
December 11, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/29394849/-three-year-survival-after-lymphadenectomy-for-residual-lymph-node-metastasis-of-esophageal-cancer-with-invasion-into-the-trachea-and-carotid-artery-after-chemoradiotherapy-a-case-report
#13
Kazuki Odagiri, Makoto Yamazaki, Koji Tanaka, Yasuhiro Miyazaki, Tomoki Makino, Tsuyoshi Takahashi, Yukinori Kurokawa, Kiyokazu Nakajima, Masaki Mori, Yuichiro Doki
INTRODUCTION: Chemoradiotherapy(CRT)is an effective treatment method for esophageal cancer. In early stages, it is a standard therapy combined with surgery. However, CRT achieves definitive complete response(CR)in only about 20% of advanced cancer with invasion into adjacent organs. Then, surgery is the only treatment for curative therapy. We report a case of a patient with 3-year survival who underwent lymphadenectomy for residual cancer after CRT for advanced esophageal cancer with invasion into the trachea and right cervical artery...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394828/-a-case-of-emergency-resection-of-esophageal-cancer-which-is-on-the-brink-of-perforation-after-neoadjuvant-chemotherapy
#14
Atsushi Yasuda, Takushi Yasuda, Yutaka Kimura, Hiroaki Kato, Yoko Hiraki, Mitsuru Iwama, Osamu Shiraishi, Masayuki Shinkai, Motohiro Imano, Haruhiko Imamoto
According to the Guidelines for Diagnosis and Treatment of Carcinoma of the Esophagus in Japan, the standard treatment of esophageal cancer with cStage II / III is preoperative chemotherapy and radical resection. But when the tumor has deep ulcer, the perforation of it is sometimes occurred due of the anti-tumor effect and we are forced to change the standard treatment. In this time, we report a case of emergency resection of esophageal cancer which is on the brink of perforation after neoadjuvant chemotherapy...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394779/-outcome-of-patients-with-pathological-complete-response-after-neoadjuvant-chemotherapy-in-advanced-esophageal-cancer
#15
Shoichiro Hikami, Atsushi Shiozaki, Hitoshi Fujiwara, Hirotaka Konishi, Tomohiro Arita, Toshiyuki Kosuga, Ryo Morimura, Yasutoshi Murayama, Shuhei Komatsu, Hisashi Ikoma, Yoshiaki Kuriu, Masayoshi Nakanishi, Daisuke Ichikawa, Kazuma Okamoto, Eigo Otsuji
Neoadjuvant chemotherapy(NAC)has been proven to have survival benefit for patients with resectable advanced esophageal squamous cell carcinoma(ESCC). Among a total of 208 patients with ESCC who underwent radical surgery following NAC between March 2000 and January 2017, 6 patients achieved histologically complete response. Before NAC, the average major axis length of the tumor was 57 mm, and the clinical stages were Stage II (2 patients)and Stage III (4 patients). FP therapy(cisplatin and 5-fluorouracil)was administered to 4 patients, and DCF therapy(docetaxel, cisplatin, and 5-fluorouracil) to 2 patients...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394778/-a-case-of-metachronous-resection-for-advanced-esophageal-cancer-with-pheochromocytoma
#16
Kohei Murakami, Atsushi Takeno, Toru Masuzawa, Shigeyuki Tamura, Kenji Kawai, Takuya Sakamoto, Junichi Inatome, Atsushi Naito, Yoshiteru Katsura, Yoshiaki Ohmura, Yoshinori Kagawa, Chiyomi Egawa, Yutaka Takeda, Kohei Murata
A 66-year-old man reporting chest stenosis was examined. Upper gastrointestinal endoscopy showed type 2 esophageal cancer. An enhanced CT scan showed several swollen lymph nodes in the lesser curvature of the esophagus. We diagnosed the patient as having advanced esophageal cancer with multiple lymph node metastases(cT3N2M0, Stage III ). After 2 courses of chemotherapy(DCF), a significant reduction was observed in the esophageal tumor; however, the tumor at the lesser curvature was almost unchanged. MIBG scintigraphy showed high uptake in the left adrenal gland...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394775/-radical-thoracoscopic-esophagectomy-for-elderly-patients-with-advanced-esophageal-cancer
#17
Yuki Matsumi, Yasuhiro Shirakawa, Shunsuke Tanabe, Satoshi Komoto, Naoaki Maeda, Takayuki Ninomiya, Kazuhiro Noma, Masahiko Nishizaki, Shunsuke Kagawa, Toshiyoshi Fujiwara
We report a case of an elderly patient with advanced esophageal cancer who underwent multidisciplinary treatment. An 86-year-old male consulted our hospital with complaints of pharynx discomfort and difficulty in swallowing. He was preoperatively diagnosed with esophageal cancer, T3N2M0, Stage III . We performed 2 courses of cisplatin plus 5-FU therapy as neoadjuvant chemotherapy. The primary tumor and metastatic lymph nodes reduced in size, and thoracoscopic esophagectomy in the prone position was performed...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394722/-a-case-of-advanced-esophageal-cancer-successfully-treated-with-dcf-chemotherapy-followed-by-conversion-surgery
#18
Kazuyuki Okada, Tomohira Takeoka, Hirofumi Miki, Kenji Kobayashi
A 66-year-old man was admitted to our hospital complaining of dysphagia. Endoscopic examination showed type 1 tumor in the middle intrathoracic esophagus. The biopsy specimen showed moderately differentiated squamous cell carcinoma. Abdominal CT scan revealed the swelling of lymph nodes along the celiac artery. We diagnosed unresectable advanced esophageal cancer(cT3N4M0, cStage IV a). Systemic chemotherapy was initiated using a regimen of docetaxel, CDDP, and 5- FU(DCF). Abdominal CT scan indicated regression of the swelling lymph nodes after 3 courses...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394686/-a-case-of-liver-metastasis-from-esophageal-cancer-successfully-treated-by-surgical-resection-after-chemotherapy-with-weekly-paclitaxel
#19
Akinori Nozawa, Naoshi Kubo, Sadatoshi Shimizu, Akihiro Murata, Akishige Kanazawa, Shintaro Kodai, Yorihisa Urata, Kotaro Miura, Jun Tauchi, Katsunori Sakurai, Akiko Tachimori, Yutaka Tamamori, Toru Inoue, Yoshito Yamashita, Yukio Nishiguchi
A 58-year-old man complaining of dysphagia was admitted to our hospital and diagnosed with esophageal cancer.He underwent thoracoscopic subtotal esophagectomy with 3-field lymph node dissection and reconstruction with a gastric tube created by hand-assisted laparoscopy.The pathological diagnosis was classified as AeLtG, pT3N2M0, pStage III .He was subsequently treated with systemic chemotherapy with 5-fluorouracil and cisplatin.After 2 courses, a single liver metastatic tumor appeared at segment 5.As chemotherapy against the recurrence, weekly-paclitaxel was administered...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394673/-case-report-of-an-acute-focal-bacterial-nephritis-associated-with-adjuvant-chemotherapy-in-esophageal-cancer-patient
#20
Yusuke Tsuruda, Hiroshi Okumura, Tetsuro Setoyama, Kiyokazu Hiwatashi, Koji Minami, Shigeho Maenohara, Yasuto Uchikado, Itaru Omoto, Ken Sasaki, Shoji Natsugoe
We report a case of acute focal bacterial nephritis(AFBN)as a complication of chemotherapy in esophageal cancer patient. A 54-year-old woman underwent thoracoscopic esophagectomy for thoracic esophageal cancer. The final pathological diagnosis was a squamous cell carcinoma, pT1b, N2(No. 110), M0, pStage II . She received adjuvant chemotherapy with docetaxel, CDDP and 5-FU(mDCF)in our hospital from February, 2016. There was no complication in first course. She visited our hospital with complaints of a fever and right flank pain on the 22 nd day after second course of chemotherapy...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
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