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esophageal cancer chemotherapy

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https://www.readbyqxmd.com/read/29679654/the-vanillin-derivative-6-bromine-5-hydroxy-4-methoxybenzaldehyde-induces-aberrant-mitotic-progression-and-enhances-radio-sensitivity-accompanying-suppression-the-expression-of-plk1-in-esophageal-squamous-cell-carcinoma
#1
Meng-Meng Gu, Ming Li, Dexuan Gao, Lang-Huan Liu, Yue Lang, Si-Ming Yang, Hongling Ou, Bo Huang, Ping-Kun Zhou, Zeng-Fu Shang
Esophageal squamous cell carcinoma (ESCC) is the most common form of esophageal cancer in China. Since chemotherapy is the standard clinical intervention for advanced ESCC, the development of highly effective and minimal/non-toxic drugs is essential to improve the clinical outcome and prognosis of the patients. A novel derivative of vanillin, 6-bromine-5-hydroxy-4-methoxybenzaldehyde (BVAN08), has been recently reported to activate different cell death pathways in cancer cells. In this study, we demonstrate that BVAN08 exhibits a potent anti-proliferation effect on ESCC cells (TE-1 and ECA-109) by inhibiting the expression of PLK1, an important mitotic kinase...
April 18, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29674273/the-potential-of-herb-medicines-in-the-treatment-of-esophageal-cancer
#2
REVIEW
Jie Ying, Miaomiao Zhang, Xiaoyan Qiu, Yu Lu
Esophageal cancer (EC) is one of common malignant neoplasms in the world. Due to dietary habits, environmental factors, stress and so on, larger numbers of person are diagnose with EC every year. Currently, the clinical treatment of EC mainly includes radiotherapy, chemotherapy, surgical resection alone or combined strategy. These treatment options are insufficient and often associated with a number of side effects. Medicinal herbs containing Traditional Chinese Medicine (TCM) have been used as an adjunct treatment for alleviating the side effects of chemotherapy or radiotherapy and for improving the quality of life of cancer patients...
April 16, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29673198/chemoresistance-to-cancer-treatment-benzo-%C3%AE-pyrene-as-friend-or-foe
#3
Kevin Dzobo, Naseeha Hassen, Dimakatso Alice Senthebane, Nicholas Ekow Thomford, Arielle Rowe, Hendrina Shipanga, Ambroise Wonkam, M Iqbal Parker, Shaheen Mowla, Collet Dandara
Background: Environmental pollution such as exposure to pro-carcinogens including benzo-α-pyrene is becoming a major problem globally. Moreover, the effects of benzo-α-pyrene (BaP) on drug pharmacokinetics, pharmacodynamics, and drug resistance warrant further investigation, especially in cancer outpatient chemotherapy where exposure to environmental pollutants might occur. Method: We report here on the effects of benzo-α-pyrene on esophageal cancer cells in vitro, alone, or in combination with chemotherapeutic drugs cisplatin, 5-flurouracil, or paclitaxel...
April 17, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29668513/prognostic-value-of-metabolic-tumor-volume-and-total-lesion-glycolysis-in-esophageal-carcinoma-patients-treated-with-definitive-chemoradiotherapy
#4
Berna A Yildirim, Nese Torun, Ozan C Guler, Cem Onal
PURPOSE: The aim of this study was to evaluate the prognostic importance metabolic tumor volume (MTV), total lesion glycolysis (TLG), and standardized uptake value (SUV) in patients with esophageal cancer treated with definitive chemoradiotherapy. PATIENTS AND METHODS: Seventy-two esophageal cancer patients treated with definitive chemoradiotherapy [57 (79%) patients] or definitive radiotherapy [15 (21%) patients] were retrospectively analyzed. The regions equal to or greater than SUV of 2...
April 17, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29666806/the-frontline-of-esophageal-cancer-treatment-questions-to-be-asked-and-answered
#5
REVIEW
Cheng-Che Tu, Po-Kuei Hsu
Achieving a good treatment for esophageal cancer is a great challenge. For early stage cancer, endoscopic treatment is considered the first line and a possible curative therapy. Chemotherapy, radiotherapy, and surgery are all used for the treatment of locally advanced esophageal cancer, administered either alone or combined. Some combinations have proven to be feasible, effective, and superior, such as neoadjuvant chemoradiation (CRT) plus surgery in the Chemoradiotherapy for Oesophageal Cancer Followed by Surgery Study (CROSS) trial...
February 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29666802/advances-in-radiotherapy-for-esophageal-cancer
#6
REVIEW
Wei Deng, Steven H Lin
Esophageal cancer is a common type of malignancy worldwide and usually requires multidisciplinary care. Radiotherapy plays an important part in management of the disease. During the past few years, researchers have made much progress about radiotherapy for esophageal cancer, which was revealed in every aspect of clinical practice. Neoadjuvant chemoradiotherapy remains the standard treatment for locally advanced esophageal cancer, whereas neoadjuvant chemotherapy appears to show less toxicities and non-inferior prognosis...
February 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29663379/phase-ib-ii-study-of-safety-and-efficacy-of-low-dose-decitabine-primed-chemo-immunotherapy-in-patients-with-drug-resistant-relapsed-refractory-alimentary-tract-cancer
#7
Meixia Chen, Jing Nie, Yang Liu, Xiang Li, Yan Zhang, Malcolm V Brock, Kaichao Feng, Zhiqiang Wu, Xiaolei Li, Lu Shi, Suxia Li, Mingzhou Guo, Qian Mei, Weidong Han
The pressing need for improved therapeutic outcomes provides a good rationale for identifying effective strategies for alimentary tract (AT) cancer treatment. The potential re-sensitivity property to chemo- and immunotherapy of low-dose decitabine has been evident both preclinically and in previous phase I trials. We conducted a phase Ib/II trial evaluating low-dose decitabine primed chemo-immunotherapy in patients with drug-resistant relapsed/refractory esophageal, gastric or colorectal cancers. Forty-five patients received either the 5-day decitabine treatment with subsequent re-administration of the previously resistant chemotherapy (decitabine primed chemotherapy, D-C cohort) or the aforementioned regimen followed by cytokine-induced killer cells therapy (decitabine primed chemotherapy and CIK treatment, D-C+CIK cohort) based on their treatment history...
April 16, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29656329/comparison-of-perioperative-and-oncological-outcome-of-thoracoscopic-esophagectomy-in-left-decubitus-position-and-in-prone-position-for-esophageal-cancer
#8
Shirou Kuwabara, Kazuaki Kobayashi, Akira Kubota, Ikuma Shioi, Kenji Yamaguchi, Norio Katayanagi
PURPOSE: The aim of this study was to clarify the differences between thoracoscopic esophagectomy in the left decubitus position (LP) and in the prone position (PP) in terms of short-term perioperative outcomes and long-term oncological outcomes after more than 5 years of follow-up. METHODS: Patients with esophageal cancer who underwent thoracoscopic esophagectomy and were followed up for more than 5 years were analyzed retrospectively. Of 142 patients, 72 underwent LP esophagectomy and 70 underwent PP esophagectomy...
April 15, 2018: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/29655462/obesity-thrombotic-risk-and-inflammation-in-cancer
#9
Benjamín Rubio-Jurado, Luz-Ma-Adriana Balderas-Peña, Eduardo E García-Luna, María G Zavala-Cerna, Carlos Riebeling-Navarro, Pedro A Reyes, Arnulfo H Nava-Zavala
Neoplasms exhibits a high incidence and mortality rates due to their complex and commonly overlapping clinical, biochemical, and morphologic profiles influenced by acquired or inherited molecular abnormalities, cell of origin, and level of differentiation. Obesity appears related to ~20% of cancers including endometrial, esophageal, colorectal, postmenopausal breast, prostate, and renal. Several factors other than obesity, i.e., insulin, insulin-like growth factor, sexual hormones, and adipokines may play a potential role in neoplasia...
2018: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/29650894/-chemoradiotherapy-the-standard-treatment-at-present
#10
Sadamoto Zenda
Chemotherapy concurrent with radiotherapy has been widely used in clinical practice because the additional benefit on radiotherapy alone had shown. Head and neck cancer: CDDP concurrent with radiotherapy has been a standard treatment for 15years both in definitive setting and postoperative setting. Esophageal cancer: 5-FU/CDDP is the best partner for radiotherapy and appropriate radiation dose has been discussed. Anal cancer: Radical concurrent chemoradiotherapy with 5-FU and mitomycin C(MMC)remains the standard of care for squamous cell carcinoma of the anus...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650889/-relationship-between-nutritional-biochemical-parameters-and-body-weight-loss-in-patients-with-esophageal-cancer-up-to-one-year-after-surgery
#11
Mio Matsuoka, Shohei Iijima
SUBJECTS AND METHODS: The subjects comprised 21 patients with esophageal cancer who underwent surgery, without adjuvant chemotherapy. Caloric intake, body weight loss, and biochemical parameters(serum albumin[Alb], hemoglobin[Hb], transthyretin[TTR], and total cholesterol[T-Cho])were measured up to 1 year after surgery, and relationships between all parameters were investigated. RESULTS: The caloric intake dropped to about 87% of base-line intake at 1 month after surgery and recovered to 100% at 1 year after the operation...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650841/-a-case-of-advanced-esophageal-cancer-successfully-treated-with-multidisciplinary-therapy
#12
Junji Kawada, Masaya Nishino, Tomoki Hata, Takayuki Ogino, Masateru Okawa, Hiromitsu Hoshino, Miho Okano, Kenichi Nagai, Naruyasu Kakita, Yongkook Kim, Masaki Okuyama, Toshimasa Tsujinaka
We report a case of advanced esophageal cancer that was successfully treated using chemotherapy, operation, and chemoradiotherapy. A 66-year-old man with advanced esophageal cancer(Mt, O-Is, T4[N0.7-stomach], N2, M0, Stage III)was administered chemotherapy(docetaxel[DOC], cisplatin[CDDP], and 5-fluorouracil[5-FU]: DCF). As the esophageal tumor achieved complete clinical response after 2 courses of chemotherapy, lymph node dissection and proximal gastrectomy were performed for the residual tumor. Abdominal CT 3 months after surgery revealed lymph node swelling...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29608256/aging-related-prognosis-analysis-of-definitive-radiotherapy-for-very-elderly-esophageal-cancer
#13
Yong-Chun Zhou, Li-Li Chen, Hong-Bo Xu, Qian Sun, Qi Zhang, Han-Fei Cai, Hao Jiang
Because of the exclusion for the patients more than 75 years (very elderly patients) in many clinical trials of esophageal cancer (EC), there is no consensus on prognosis and treatment for this population. We aim to evaluate the outcomes and aging-related prognostic factors of definitive radiotherapy (RT) for very elderly EC patients. We retrospectively analyzed 149 very elderly EC patients consecutively treated between January 2015 and June 2016 by definitive intensity-modulated radiotherapy (IMRT) with or without chemotherapy...
April 2, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29607947/multimodality-therapy-including-proton-beam-therapy-for-afp-producing-esophageal-cancer-with-multiple-liver-metastases
#14
Tatsuya Miyazaki, Makoto Sohda, Makoto Sakai, Yuji Kumakura, Tomonori Yoshida, Kengo Kuriyama, Takehiko Yokobori, Masaya Miyazaki, Junko Hirato, Toshiyuki Okumura, Hitoshi Ishikawa, Hideyuki Sakurai, Hiroyuki Kuwano
A 50-year-old man who presented with a fever and epigastralgia was diagnosed to have esophageal carcinoma which was identified as poorly differentiated adenocarcinoma producing AFP with Barrett's esophagus. Computed tomography revealed multiple liver metastases and lymph node metastases surrounding the stomach. We first performed chemotherapy for the systemic lesions and proton beam therapy for the local control of lesions without complete remission and we were able to successfully control the frequently recurring lesions by proton beam therapy, cryotherapy and chemotherapy...
March 30, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29607302/predisposing-factors-for-chemotherapy-induced-nephrotoxicity-in-patients-with-advanced-esophageal-cancer-who-received-combination-chemotherapy-with-docetaxel-cisplatin-and-5-fluorouracil
#15
Junichi Mohri, Chikatoshi Katada, Marie Ueda, Mitsuhiro Sugawara, Keishi Yamashita, Hiromitsu Moriya, Shouko Komori, Kazushige Hayakawa, Wasaburo Koizumi, Koichiro Atsuda
Background and Objectives: We retrospectively studied the predisposing factors for nephrotoxicity in the patients with advanced esophageal squamous-cell carcinoma who received combination chemotherapy with docetaxel, cisplatin, and 5-fluorouracil (DCF therapy). Methods: Between January 2010 and March 2014, 41 patients with Stage IB to III esophageal squamous-cell carcinoma received the DCF therapy (docetaxel 70-75 mg/m2 , day 1; cisplatin 70-75 mg/m2 , day 1; 5-fluorouracil 750 mg/m2 , days 1-5) in our hospital...
March 2018: Journal of Translational Internal Medicine
https://www.readbyqxmd.com/read/29603271/totally-minimally-invasive-esophagectomy-after-neoadjuvant-chemoradiotherapy-long-term-oncologic-outcomes
#16
Merel Lubbers, Marc J van Det, Mariska J Kreuger, Ronald Hoekstra, Ellen M Hendriksen, Marloes Vermeer, Ewout A Kouwenhoven
BACKGROUND AND OBJECTIVES: Minimally invasive esophagectomy is emerging with comparable short-term outcomes as open esophagectomies. Neoadjuvant chemoradiotherapy followed by surgery is considered standard of care in the Netherlands for patients with esophageal cancer. The aim of this study was to analyze the long-term oncologic outcome after neoadjuvant chemoradiotherapy followed by totally minimally invasive esophagectomy. METHODS: Neoadjuvant carboplatin and paclitaxel based chemotherapy was concomitantly given with 41...
March 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29601131/pathological-tumor-regression-grade-of-metastatic-tumors-in-lymph-node-predicts-prognosis-in-esophageal-cancer-patients
#17
Tomohiro Kadota, Ken Hatogai, Tomonori Yano, Takeo Fujita, Takashi Kojima, Hiroyuki Daiko, Satoshi Fujii
Tumor regression grade of the primary tumor (TRG-PT) and residual lymph node metastasis have been pathologically determined in esophageal squamous cell carcinoma (ESCC) patients who had received neoadjuvant chemotherapy (nCT) followed by surgery; however, TRG of the metastatic tumor involving lymph nodes (LNs) has not yet been determined. The aim of this study was to clarify the impact of TRG on the ESCC patients' prognosis. ESCC patients (n=110) who had received nCT followed by surgery were enrolled. Dissected LNs were classified into two categories: plausible positive metastatic LNs (pp-MLNs) where viable and/or degenerated ESCC cells and/or tissue modifications were observed, and non-metastatic LNs (non-MLNs) where neither of them was observed...
March 30, 2018: Cancer Science
https://www.readbyqxmd.com/read/29600230/standard-dose-versus-high-dose-radiotherapy-with-concurrent-chemotherapy-in-esophageal-cancer-a-prospective-randomized-study
#18
Navin Nayan, M Bhattacharyya, Vikas K Jagtap, A K Kalita, R Sunku, P S Roy
Objective: The objective of this study is comparision of local and distant control rates with high-dose versus standard-dose radiotherapy along with concurrent chemotherapy in esophageal cancer - a prospective randomized study. Materials and Methods: Histologically proven Stage I-III patients with carcinoma esophagus were randomized into two groups. One group has been treated with standard-dose radiotherapy, i.e., a total dose of 50.4 Gy (1.8 Gy/day, 28#, 5 days/week)...
January 2018: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/29600225/comparison-of-health-related-quality-of-life-with-epirubicin-cisplatin-plus-5-fluorouracil-and-docetaxel-cisplatin-plus-5-fluorouracil-chemotherapy-regimens-as-first-line-systemic-therapy-in-locally-advanced-inoperable-or-metastatic-gastric-or-gastro-esophageal
#19
K Govind Babu, Tamojit Chaudhuri, K C Lakshmaiah, Lokanatha Dasappa, Linu Abraham Jacob, M C Suresh Babu, A H Rudresha, K N Lokesh, L K Rajeev
Background: Health-related quality of life (HRQOL) is an important oncologic end point for upper gastrointestinal malignancies. Unfortunately, till date, there is no published prospective data from India, comparing the HRQOL parameters between first-line chemotherapy regimens in advanced/metastatic gastric cancer. Materials and Methods: The present study aimed to compare the HRQOL of first-line systemic chemotherapy with epirubicin, cisplatin plus 5-FU (ECF) and docetaxel, cisplatin plus 5-FU (DCF) regimens in patients with locally advanced inoperable or metastatic gastric or gastro-esophageal junction adenocarcinoma...
January 2018: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/29587605/chondritis-of-the-ear-after-docetaxel-carboplatin-chemotherapy
#20
Tae Hoon Kong, Sung Min Han, Young Joon Seo
Docetaxel, derived from the yew tree, belongs to the taxane family of medications. It works by disrupting the normal function of microtubules, thereby stopping cell division. Docetaxel is used in the treatment of ovarian, breast, esophageal, gastric, prostate, lung, and head and neck cancers. Common side effects include hair loss, low blood cell counts, peripheral neuropathy, vomiting, and muscle pain. Auricular chondritis with ear deformity has not been reported previously as a side effect of docetaxel. In this paper, we present the case of a 64-year-old male patient with chondritis accompanied by ear deformity that developed due to docetaxel-carboplatin chemotherapy for non-small cell lung cancer...
January 1, 2018: Journal of Oncology Pharmacy Practice
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