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esophageal cancer chemotherapy

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https://www.readbyqxmd.com/read/28723625/2-acetylamino-3-4-2-acetylamino-2-carboxyethylsulfanylcarbonylamino-phenyl-carbamoylsulfanyl-propionic-acid-a-glutathione-reductase-inhibitor-induces-g2-m-cell-cycle-arrest-through-generation-of-thiol-oxidative-stress-in-human-esophageal-cancer-cells
#1
Xia Li, Zhiming Jiang, Jianguo Feng, Xiaoying Zhang, Junzhou Wu, Wei Chen
Esophageal squamous cell carcinoma (ESCC) is a highly malignant cancer with poor response to both of chemotherapy and radiotherapy. 2-Acetylamino-3-[4-(2-acetylamino-2-carboxyethylsulfanylcarbonylamino) phenyl carbamoylsulfanyl] propionic acid (2-AAPA), an irreversible inhibitor of glutathione reductase (GR), is able to induce intracellular oxidative stress, and has shown anticancer activity in many cancer cell lines. In this study, we investigated the effects of 2-AAPA on the cell proliferation, cell cycle and apoptosis and aimed to explore its mechanism of action in human esophageal cancer TE-13 cells...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28711918/prognostic-significance-of-the-size-and-number-of-lymph-nodes-on-pre-and-post-neoadjuvant-chemotherapy-ct-in-patients-with-pn0-esophageal-squamous-cell-carcinoma-a-5-year-follow-up-study
#2
Yong-Kun Chi, Ying Chen, Xiao-Ting Li, Ying-Shi Sun
The prognosis of patients with esophageal cancer improves by using neoadjuvant chemotherapy (NAC). More patients obtain pathological N0 staging (pN0) after surgery. The heterogeneity of prognosis of these patients poses a great challenge of customizing therapeutic strategies for individual patients. The signs of lymph nodes on both pre and post NAC computer tomography (CT) scan can provide more information for evaluation. Therefore, we investigated a new approach to lymph node (LN)-survival analysis by using pre-/post-NAC CT in pN0 esophageal cancer...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28711321/importance-of-positron-emission-tomography-for-assessing-the-response-of-primary-and-metastatic-lesions-to-induction-treatments-in-t4-esophageal-cancer
#3
Tomoki Makino, Makoto Yamasaki, Koji Tanaka, Mitsuaki Tatsumi, Shuji Takiguchi, Jun Hatazawa, Masaki Mori, Yuichiro Doki
BACKGROUND: There is no consensus strategy for treatment of T4 esophageal cancer, and because of this, a better evaluation of treatment response is crucial to establish personalized therapies. This study aimed to establish a useful system for evaluating treatment response in T4 esophageal cancer. METHODS: This study included 130 patients with cT4 esophageal cancer without distant metastasis who underwent (18)F-fluorodeoxyglucose-positron emission tomography before and after a series of induction treatments comprising chemoradiation or chemotherapy...
July 12, 2017: Surgery
https://www.readbyqxmd.com/read/28709645/usefulness-of-computed-tomography-number-of-a-tumor-in-predicting-the-response-of-advanced-esophageal-cancer-to-preoperative-chemotherapy
#4
Kohei Wakatsuki, Sohei Matsumoto, Kazuhiro Migita, Masahiro Ito, Tomohiro Kunishige, Hiroshi Nakade, Mitsuhiro Nakatani, Mutsuko Kitano, Masato Takano, Chiho Obayashi, Masayuki Sho
BACKGROUND: In Japan, preoperative chemotherapy is considered essential for resectable stage II or III esophageal cancers. It is important to identify nonresponders for preoperative chemotherapy because continuing ineffective chemotherapy is not beneficial for them. We investigated the correlation between the computed tomography number of tumor and the effect of preoperative chemotherapy in patients with esophageal cancer. METHODS: This retrospective study included 50 patients receiving preoperative chemotherapy with docetaxel, cisplatin, and 5-fluorouracil for stage II or III esophageal cancer...
July 11, 2017: Surgery
https://www.readbyqxmd.com/read/28707966/targeted-molecular-ablation-of-cancer-stem-cells-for-curing-gastrointestinal-cancers
#5
Yong Seok Kim, Ho Jae Lee, Jong-Min Park, Young-Min Han, Napapan Kangwan, Ji Young Oh, Dong Yoon Lee, Ki Baik Hahm
Abundance of the ATPase-binding cassette (ABC) transporters and deranged self-renewal pathways characterize the presence of cancer stem cells (CSCs) in gastrointestinal cancers (GI cancers), which play crucial roles in tumorigenesis, chemotherapy resistance, tumor recurrence, and cancer metastasis. Therefore, in order to ensure high cure rates, chemoquiescence, CSCs should be ablated. Recent advances in either understanding CSCs or biomarker identification enable scientists to develop techniques for ablating CSCs and clinicians to provide cancer cure, especially in GI cancers characterized by inflammation-driven carcinogenesis...
July 14, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28705182/chemoradiation-in-elderly-esophageal-cancer-patients-rationale-and-design-of-a-phase-i-ii-multicenter-study-osage
#6
Stéphanie Servagi-Vernat, Gilles Créhange, Franck Bonnetain, Cécile Mertens, Etienne Brain, Jean François Bosset
BACKGROUND: The management of elderly patients with cancer is a therapeutic challenge and a public health problem. Definitive chemoradiotherapy (CRT) is an accepted standard treatment for patients with locally advanced esophageal cancer who cannot undergo surgery. However, there are few reports regarding tolerance to CRT in elderly patients. We previously reported results for CRT in patients aged ≥75 years. Following this first phase II trial, we propose to conduct a phase I/II study to evaluate the combination of carboplatin and paclitaxel, with concurrent RT in unresectable esophageal cancer patients aged 75 years or older...
July 13, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28693258/mlh1-expression-predicts-the-response-to-preoperative-therapy-and-is-associated-with-pd-l1-expression-in-esophageal-cancer
#7
Kota Momose, Makoto Yamasaki, Koji Tanaka, Yasuhiro Miyazaki, Tomoki Makino, Tsuyoshi Takahashi, Yukinori Kurokawa, Kiyokazu Nakajima, Shuji Takiguchi, Masaki Mori, Yuichiro Doki
Programmed death-ligand 1 (PD-1/PD-L1) inhibition therapy demonstrates potential as a future treatment for esophageal cancer. Mismatch repair status and tumor PD-L1 expression are the candidate predictive biomarkers for response to this therapy. In colorectal cancer, mismatch repair-deficient tumors are associated with improved survival, although they are not sensitive to 5-fluorouracil-based chemotherapy. The purpose of the present study was to investigate the association between MutL homolog 1 (MLH1) expression and prognosis, response to therapy and PD-L1 expression in esophageal cancer...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28685086/outcomes-of-aggressive-treatment-in-esophageal-cancer-patients-with-synchronous-solitary-brain-metastasis
#8
Cem Onal, Berna Akkus Yildirim, Ozan Cem Guler
The aim of the present study was to investigate the outcomes of esophageal cancer (EC) patients with isolated synchronous brain oligometastasis (oligo-BM) treated with chemoradiotherapy (CRT) of the primary site and localized treatment of the BM with surgery, radiotherapy (RT) or radiosurgery. Of 125 EC patients investigated, seven patients (6%) had solitary BM. Six patients were diagnosed prior to, and one patient was diagnosed during, treatment. All patients were treated with neoadjuvant chemotherapy and whole-brain RT (WBRT) for BM...
July 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28685065/increased-neutrophil-to-lymphocyte-ratio-is-a-novel-marker-for-nutrition-inflammation-and-chemotherapy-outcome-in-patients-with-locally-advanced-and-metastatic-esophageal-squamous-cell-carcinoma
#9
Yu Sato, Kenji Gonda, Maiko Harada, Yuki Tanisaka, Shin Arai, Yumi Mashimo, Hirotoshi Iwano, Hiroshi Sato, Shomei Ryozawa, Takao Takahashi, Shinichi Sakuramoto, Masahiko Shibata
Esophageal squamous cell carcinoma (ESCC) is one of the most common types of cancer, and its progression is strongly influenced by the presence of inflammation. Recently, there has been growing interest in the host inflammatory response, and increasing evidence has indicated that the neutrophil-to-lymphocyte ratio (NLR), a useful marker of systemic inflammation, may be an effective prognostic indicator in various types of malignant diseases. In the present study, 260 patients with ESCC were enrolled, including 110 who received chemoradiation therapy (CRT) involving irradiation and chemotherapy of 5-fluorouracil and cisplatin, and 150 received chemotherapy using 5-fluorouracil and cisplatin (FP)...
July 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28683820/primary-radio-chemo-therapy-for-esophageal-cancer-in-elderly-patients-are-efficiency-and-toxicity-comparable-with-younger-patients
#10
Stefan Münch, Christine Heinrich, Daniel Habermehl, Markus Oechsner, Stephanie E Combs, Marciana-Nona Duma
PURPOSE: In elderly patients with esophageal cancer (EC), esophagectomy is associated with an increased mortality, and therefore these patients are often treated with definite (chemo)radiation. The purpose of this study was to assess the toxicity and efficiency of definite radio(chemo)therapy in patients >75 years compared with definite radio(chemo)therapy in patients <75 years. METHODS: 32 patients >75 years were treated with definite radio(chemo)therapy for EC...
July 6, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/28683449/101-long-term-survivors-who-had-metastatic-gastroesophageal-cancer-and-received-local-consolidative-therapy
#11
Dilsa Mizrak Kaya, Xuemei Wang, Kazuto Harada, Mariela A Blum Murphy, Prajnan Das, Bruce D Minsky, Jeannelyn S Estrella, Quan Lin, Fatemeh G Amlashi, Jeffrey H Lee, Brian Weston, Manoop S Bhutani, Aurelio Matamoros, Tara Sagebiel, Carol C Wu, Jane E Rogers, Irene Thomas, Dipen M Maru, Heath D Skinner, Brian D Badgwell, Wayne L Hofstetter, Jaffer A Ajani
BACKGROUND: Through a multidisciplinary decision-making process, we developed a strategy of systemic therapy followed by local consolidative therapy (chemoradiation with/without surgery) in selected patients with metastatic gastroesophageal carcinoma (mGEAC). Only after a consensus during multidisciplinary discussions, local therapy was initiated. METHODS: We identified 101 patients with mGEAC who had local consolidation. We evaluated the association between various clinical variables (location of the primary, location of metastases, duration of initial chemotherapy, histologic grade, and radiation dose) and overall survival (OS)...
July 6, 2017: Oncology
https://www.readbyqxmd.com/read/28678752/what-is-the-optimal-radiation-dose-for-non-operable-esophageal-cancer-dissecting-the-evidence-in-a-meta-analysis
#12
Yong Chen, Hui-Ping Zhu, Tao Wang, Chang-Jiang Sun, Xiao-Lin Ge, Ling-Feng Min, Xian-Wen Zhang, Qing-Qing Jia, Jie Yu, Jian-Qi Yang, Heike Allgayer, Mohammed L Abba, Xi-Zhi Zhang, Xin-Chen Sun
The standard radiation dose 50.4 Gy with concurrent chemotherapy for localized inoperable esophageal cancer as supported by INT-0123 trail is now being challenged since a radiation dose above 50 Gy has been successfully administered with an observable dose-response relationship and insignificant untoward effects. Therefore, to ascertain the treatment benefits of different radiation doses, we performed a meta-analysis with 18 relative publications. According to our findings, a dose between 50 and 70 Gy appears optimal and patients who received ≥ 60 Gy radiation had a significantly better prognosis (pooled HR = 0...
June 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28678434/prospective-study-of-proton-beam-radiation-therapy-for-limited-stage-small-cell-lung-cancer
#13
Jean-Claude M Rwigema, Vivek Verma, Liyong Lin, Abigail T Berman, William P Levin, Tracey L Evans, Charu Aggarwal, Ramesh Rengan, Corey Langer, Roger B Cohen, Charles B Simone
BACKGROUND: Existing data supporting the use of proton-beam therapy (PBT) for limited-stage small cell lung cancer (LS-SCLC) are limited to a single 6-patient case series. This is the first prospective study to evaluate clinical outcomes and toxicities of PBT for LS-SCLC. METHODS: This study prospectively analyzed patients with primary, nonrecurrent LS-SCLC definitively treated with PBT and concurrent chemotherapy from 2011 to 2016. Clinical backup intensity-modulated radiotherapy (IMRT) plans were generated for each patient and were compared with PBT plans...
July 5, 2017: Cancer
https://www.readbyqxmd.com/read/28668875/neck-dissection-and-thoracoscopic-esophagectomy-in-esophageal-cancer-with-aberrant-subclavian-artery
#14
Hiroyuki Kitagawa, Tsutomu Namikawa, Kazuhiro Hanazaki
We report a case of esophageal cancer with a non-recurrent inferior laryngeal nerve associated with aberrant right subclavian artery treated with neck dissection followed by thoracoscopic esophagectomy. A 60-year-old man experienced esophageal cancer, hoarseness, and left supraclavicular lymph node swelling was noted on endoscopy. Computed tomography revealed an aberrant right subclavian artery between the esophagus and vertebrae. We administered neo-adjuvant chemotherapy and performed thoracoscopic esophagectomy...
July 2017: Anticancer Research
https://www.readbyqxmd.com/read/28668869/clinical-outcomes-of-resectable-esophageal-cancer-with-supraclavicular-lymph-node-metastases-treated-with-curative-intent
#15
Yoshitaka Honma, Nobukazu Hokamura, Kengo Nagashima, Kazuki Sudo, Hirokazu Shoji, Satoru Iwasa, Atsuo Takashima, Ken Kato, Tetsuya Hamaguchi, Narikazu Boku, Rei Umezawa, Yoshinori Ito, Jun Itami, Kazuo Koyanagi, Hiroyasu Igaki, Yuji Tachimori
BACKGROUND: In the seventh edition of the Union for International Cancer Control (UICC) TNM classification, supraclavicular lymph node (SCLN) in regard to thoracic esophageal cancer (EC) is regarded as a distant organ, therefore, if resectable, SCLN metastasis is considered a candidate for systemic chemotherapy. The purpose of this study was to clarify the survival outcome in patients with resectable thoracic EC with SCLN metastases (M1LYM) treated with curative intent. PATIENTS AND METHODS: Clinical outcomes in patients with resectable thoracic EC with SCLN metastases (M1LYM) treated by esophagectomy or definitive chemoradiotherapy (dCRT) were retrospectively analyzed...
July 2017: Anticancer Research
https://www.readbyqxmd.com/read/28667862/icariin-exerts-inhibitory-effects-on-the-growth-and-metastasis-of-kyse70-human-esophageal-carcinoma-cells-via-pi3k-akt-and-stat3-pathways
#16
Zhen-Fang Gu, Zi-Teng Zhang, Jun-Ye Wang, Bao-Bin Xu
Esophageal cancer is one of the leading causes of cancer related mortality across the globe. The current treatment options are insufficient and are associated with number of side effects. Therefore there is a pressing need to develop effective and more efficient strategies for the treatment of esophageal cancer. Consistently, natural products are considered potential candidates for develop of cancer chemotherapy. Icariin is a naturally occurring flavonol glucoside and has been reported to possess tremendous pharmacological potential ranging from neuroprotection to anticancer activity...
June 19, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28666190/chemotherapy-induces-oral-mucositis-in-mice-without-additional-noxious-stimuli
#17
M Bertolini, T Sobue, A Thompson, A Dongari-Bagtzoglou
Oral mucositis (OM) is a serious side effect of cancer chemotherapy. The pathobiology of oral mucositis remains incompletely understood due to lack of appropriate models which recapitulate the human condition. Existing rodent models are intraperitoneal and require radiation, chemical or mechanical injury to the chemotherapy protocol to induce oral lesions. We aimed to develop an OM mouse model that is induced solely by chemotherapy and reproduces macroscopic, histopathologic and inflammatory characteristics of the human condition...
June 27, 2017: Translational Oncology
https://www.readbyqxmd.com/read/28664431/investigation-of-operative-outcomes-of-thoracoscopic-esophagectomy-after-triplet-chemotherapy-with-docetaxel-cisplatin-and-5-fluorouracil-for-advanced-esophageal-squamous-cell-carcinoma
#18
Yuji Akiyama, Takeshi Iwaya, Fumitaka Endo, Takehiro Chiba, Takeshi Takahara, Koki Otsuka, Hiroyuki Nitta, Keisuke Koeda, Masaru Mizuno, Yusuke Kimura, Akira Sasaki
BACKGROUND: Preoperative chemotherapy with cisplatin and 5-fluorouracil (CF) has become the standard treatment for resectable stage II/III thoracic esophageal carcinoma in Japan. Recently, preoperative triplet chemotherapy with docetaxel, cisplatin, and 5-fluorouracil (DCF) has been reported to be effective for locally advanced esophageal cancer. Thoracoscopic esophagectomy (TE) has been increasingly accepted worldwide for the treatment of esophageal cancer. We conducted a retrospective study to evaluate the safety and outcomes of TE after DCF therapy for patients with advanced esophageal cancer...
June 29, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28652754/unusual-delayed-presentation-of-diaphragmatic-hernia-complicated-by-transverse-colon-and-total-small-bowel-obstruction-after-postoperative-chemotherapy-of-esophageal-cancer
#19
Yanlai Sun, Lei Yin, Hongfan Xue, Haipeng Wang, Zengjun Li, Jinming Yu
Diaphragmatic hernia (DH) is defined as the passage of abdominal contents into the chest cavity through a defect in the diaphragm. DH occurs after chest or abdominal surgery, and is very rare and sporadically reported in the literature. However, the complications are significant and put the patient at great risk. The aim of the present report was to describe a special case with postesophagectomy diaphragmatic hernia (PDH) because of its appearance during chemotherapy and confusion of the symptoms with the side effects of chemotherapy...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28642830/a-rare-case-of-esophageal-adenocarcinoma-with-urinary-bladder-metastasis
#20
Heather Katz, Rahoma E Saad, Krista Denning, Toni O Pacioles
Metastatic esophageal adenocarcinoma to the urinary bladder is extremely rare. We describe a previously healthy 49-year-old female with recent diagnosis of adenocarcinoma of the gastroesophageal junction with metastatic disease to the liver. Biopsy was positive for human epidermal growth factor receptor 2 (HER2) by Fluorescence In Situ Hybridization (FISH). She received six cycles of Cisplatin, 5-Fluorouracil, and Herceptin and subsequently developed symptomatic anemia and hematuria. Cystoscopy with retroflexion was performed and she received a transurethral resection of bladder tumor with fulguration...
2017: Case Reports in Gastrointestinal Medicine
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